WO2023028084A3 - Methods and compositions of nucleic acid encapsulated within external membranes - Google Patents

Methods and compositions of nucleic acid encapsulated within external membranes Download PDF

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Publication number
WO2023028084A3
WO2023028084A3 PCT/US2022/041272 US2022041272W WO2023028084A3 WO 2023028084 A3 WO2023028084 A3 WO 2023028084A3 US 2022041272 W US2022041272 W US 2022041272W WO 2023028084 A3 WO2023028084 A3 WO 2023028084A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
nucleic acid
acid encapsulated
external membranes
Prior art date
Application number
PCT/US2022/041272
Other languages
French (fr)
Other versions
WO2023028084A2 (en
Inventor
Han Liang LIM
Trevor Vernon GALE
Eddie Yocon CHUNG
Bianca Celeste KARPINECZ
Original Assignee
Coastar Therapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coastar Therapeutics Inc. filed Critical Coastar Therapeutics Inc.
Publication of WO2023028084A2 publication Critical patent/WO2023028084A2/en
Publication of WO2023028084A3 publication Critical patent/WO2023028084A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes

Abstract

Embodiments of the present disclosure relate to methods of manufacturing and generating nanoparticles comprising nucleic acids and an external membrane. Also provided are compositions comprising the nucleic acid nanoparticles, and methods of use the compositions for therapeutic and medical contexts.
PCT/US2022/041272 2021-08-27 2022-08-23 Methods and compositions of nucleic acid encapsulated within external membranes WO2023028084A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163260645P 2021-08-27 2021-08-27
US63/260,645 2021-08-27

Publications (2)

Publication Number Publication Date
WO2023028084A2 WO2023028084A2 (en) 2023-03-02
WO2023028084A3 true WO2023028084A3 (en) 2023-04-06

Family

ID=85323432

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2022/041272 WO2023028084A2 (en) 2021-08-27 2022-08-23 Methods and compositions of nucleic acid encapsulated within external membranes

Country Status (1)

Country Link
WO (1) WO2023028084A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120263783A1 (en) * 2009-10-20 2012-10-18 The Regents Of The University Of California Single molecule nucleic acid nanoparticles
WO2021011826A1 (en) * 2019-07-16 2021-01-21 Coastar Therapeutics Inc. Process of making membrane lipid coated nanoparticles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120263783A1 (en) * 2009-10-20 2012-10-18 The Regents Of The University Of California Single molecule nucleic acid nanoparticles
WO2021011826A1 (en) * 2019-07-16 2021-01-21 Coastar Therapeutics Inc. Process of making membrane lipid coated nanoparticles

Also Published As

Publication number Publication date
WO2023028084A2 (en) 2023-03-02

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