WO2023017889A1 - Méthode et dispositif pour diagnostiquer un accident vasculaire cérébral ischémique aigu à l'aide d'un modèle d'apprentissage profond basé sur un réseau neuronal à convolution (cnn) tridimensionnel (3d) - Google Patents

Méthode et dispositif pour diagnostiquer un accident vasculaire cérébral ischémique aigu à l'aide d'un modèle d'apprentissage profond basé sur un réseau neuronal à convolution (cnn) tridimensionnel (3d) Download PDF

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WO2023017889A1
WO2023017889A1 PCT/KR2021/011277 KR2021011277W WO2023017889A1 WO 2023017889 A1 WO2023017889 A1 WO 2023017889A1 KR 2021011277 W KR2021011277 W KR 2021011277W WO 2023017889 A1 WO2023017889 A1 WO 2023017889A1
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ischemic stroke
acute ischemic
deep learning
model
learning model
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PCT/KR2021/011277
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English (en)
Korean (ko)
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이대인
염규선
박승
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충북대학교병원
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    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007Evaluating blood vessel condition, e.g. elasticity, compliance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064Evaluating the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4806Functional imaging of brain activation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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    • G06T7/0002Inspection of images, e.g. flaw detection
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    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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    • G06T7/10Segmentation; Edge detection
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/40ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10088Magnetic resonance imaging [MRI]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30016Brain

Definitions

  • the present applicant has come to the present invention by recognizing the limitations of the prior art and conducting research that can help prognosis treatment and secondary prevention by predicting a more accurate mechanism of occurrence for patients with acute ischemic stroke.
  • the present invention is the first technology to classify subtypes of stroke mechanisms by analyzing acute ischemic stroke lesion patterns through deep learning based on 3D-CNN using DWI and ADC of patients with acute ischemic stroke.
  • the main results according to the present invention are as follows. First, the 3D-CNN-based segmentation accuracy for acute ischemic stroke lesions was found to be 0.843 in the Dyce score. Second, in terms of subtype classification to classify causes of acute ischemic stroke, the predictive value of cause classification according to TOAST classification was 81.3% for LAA, 84.6% for SVO, and 73.0% for CE, respectively.
  • FIG. 7 is a block diagram illustrating a diagnosis device 700 according to the present invention
  • FIG. 8 is a flowchart illustrating a diagnosis method performed by the diagnosis device 700.
  • a diagnosis apparatus and method according to the present invention will be described with reference to FIGS. 7 and 8 , but details overlapping with those described above will be omitted.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Artificial Intelligence (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Neurosurgery (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Mathematical Physics (AREA)
  • Psychiatry (AREA)
  • Quality & Reliability (AREA)
  • Image Analysis (AREA)

Abstract

La présente invention concerne une méthode pour diagnostiquer un accident vasculaire cérébral ischémique aigu à l'aide d'un modèle d'apprentissage profond basé sur un réseau neuronal à convolution (CNN) tridimensionnel (3D), laquelle méthode consiste à : collecter des données de volume 3D qui sont des données générées par imagerie du cerveau d'un patient et qui comprennent une image pondérée en fonction de la diffusion (DWI) et une carte de coefficient de diffusion apparent (ADC); utiliser un modèle de segmentation de lésion appris comme modèle d'apprentissage profond prédéfini pour segmenter et délivrer une zone de lésion associée à un accident vasculaire cérébral ischémique aigu à partir des données de volume 3D; et utiliser un modèle de classification de type inférieur appris comme modèle d'apprentissage profond prédéfini pour classifier et délivrer un type inférieur correspondant au mécanisme causal d'accident vasculaire cérébral ischémique aigu sur la base des données de volume 3D et de la zone de lésion segmentée.
PCT/KR2021/011277 2021-08-10 2021-08-24 Méthode et dispositif pour diagnostiquer un accident vasculaire cérébral ischémique aigu à l'aide d'un modèle d'apprentissage profond basé sur un réseau neuronal à convolution (cnn) tridimensionnel (3d) WO2023017889A1 (fr)

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KR1020210105131A KR102586853B1 (ko) 2021-08-10 2021-08-10 3d-cnn 기반의 딥러닝 모델을 이용한 급성 허혈성 뇌졸중 진단 정보 제공 장치 및 방법
KR10-2021-0105131 2021-08-10

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Citations (4)

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Publication number Priority date Publication date Assignee Title
KR101854071B1 (ko) * 2017-01-13 2018-05-03 고려대학교 산학협력단 딥러닝을 사용하여 관심 부위 이미지를 생성하는 방법 및 장치
KR101894722B1 (ko) * 2018-03-12 2018-10-04 미디어젠(주) 언어 장애 발생 진단을 이용한 건강 이상 예측시스템 및 예측방법
KR102015473B1 (ko) * 2017-06-22 2019-08-28 연세대학교 산학협력단 신경계 질환 관리를 위한 시스템 및 방법
KR102211050B1 (ko) * 2020-12-01 2021-02-04 (주)엔브레인 의료 영상 정보를 이용한 인공지능 기반 뇌 정보 제공 장치

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Publication number Priority date Publication date Assignee Title
KR102015224B1 (ko) 2018-09-18 2019-10-21 (주)제이엘케이인스펙션 딥러닝 기반의 뇌출혈 및 뇌종양 병변 진단 방법 및 장치

Patent Citations (4)

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KR101854071B1 (ko) * 2017-01-13 2018-05-03 고려대학교 산학협력단 딥러닝을 사용하여 관심 부위 이미지를 생성하는 방법 및 장치
KR102015473B1 (ko) * 2017-06-22 2019-08-28 연세대학교 산학협력단 신경계 질환 관리를 위한 시스템 및 방법
KR101894722B1 (ko) * 2018-03-12 2018-10-04 미디어젠(주) 언어 장애 발생 진단을 이용한 건강 이상 예측시스템 및 예측방법
KR102211050B1 (ko) * 2020-12-01 2021-02-04 (주)엔브레인 의료 영상 정보를 이용한 인공지능 기반 뇌 정보 제공 장치

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PARK SEUNG, KIM BAIK-KYUN, HAN MOON-KU, HONG JEONG-HO, YUM KYU SUN, LEE DAE-IN: "Deep Learning for Prediction of Mechanism in Acute Ischemic Stroke Using Brain MRI", RESEARCH SQUARE, 11 June 2021 (2021-06-11), XP093034346, DOI: 10.21203/rs.3.rs-604141/v1 *

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KR102586853B1 (ko) 2023-10-12

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