WO2023014293A3 - A ph-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a ph-responsive composition - Google Patents
A ph-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a ph-responsive composition Download PDFInfo
- Publication number
- WO2023014293A3 WO2023014293A3 PCT/SG2022/050532 SG2022050532W WO2023014293A3 WO 2023014293 A3 WO2023014293 A3 WO 2023014293A3 SG 2022050532 W SG2022050532 W SG 2022050532W WO 2023014293 A3 WO2023014293 A3 WO 2023014293A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cargo
- responsive composition
- rich
- encapsulating
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000017 hydrogel Substances 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicinal Preparation (AREA)
Abstract
There is provided a pH-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a pH-responsive composition, the composition comprising, a copolymer comprising, a backbone moiety; and a plurality of side moieties grafted to the backbone moiety, the plurality of side moieties comprising at least one adenine-rich (A-rich) oligonucleotide and at least one cytosine-rich (C-rich) oligonucleotide; wherein the copolymer is configured to form a hydrogel when exposed to an environment with a pH falling in a first range of pH values, thereby facilitating encapsulation of the cargo within the hydrogel; and wherein the copolymer is configured to form a solution when exposed to an environment with a pH falling in a second range of pH values different from the first range of pH values, thereby facilitating release of the cargo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10202108447X | 2021-08-02 | ||
| SG10202108447X | 2021-08-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2023014293A2 WO2023014293A2 (en) | 2023-02-09 |
| WO2023014293A3 true WO2023014293A3 (en) | 2023-04-13 |
Family
ID=85156469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/SG2022/050532 WO2023014293A2 (en) | 2021-08-02 | 2022-07-26 | A ph-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a ph-responsive composition |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2023014293A2 (en) |
-
2022
- 2022-07-26 WO PCT/SG2022/050532 patent/WO2023014293A2/en unknown
Non-Patent Citations (5)
| Title |
|---|
| BI YANHUI, DU XIAOXUE, HE PINGPING, WANG CHUNYAN, LIU CHANG, GUO WEIWEI: "Smart Bilayer Polyacrylamide/DNA Hybrid Hydrogel Film Actuators Exhibiting Programmable Responsive and Reversible Macroscopic Shape Deformations", SMALL, WILEY, HOBOKEN, USA, vol. 16, no. 42, 1 October 2020 (2020-10-01), Hoboken, USA, pages 1906998, XP093061039, ISSN: 1613-6810, DOI: 10.1002/smll.201906998 * |
| HU YUWEI, GAO SHUJUN, LU HONGFANG, YING JACKIE Y.: "Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 12, 30 March 2022 (2022-03-30), pages 5461 - 5470, XP093061044, ISSN: 0002-7863, DOI: 10.1021/jacs.1c13426 * |
| REN JIANGTAO, HU YUWEI, LU CHUN-HUA, GUO WEIWEI, ALEMAN-GARCIA MIGUEL ANGEL, RICCI FRANCESCO, WILLNER ITAMAR: "pH-responsive and switchable triplex-based DNA hydrogels", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 6, no. 7, 1 January 2015 (2015-01-01), United Kingdom , pages 4190 - 4195, XP093061034, ISSN: 2041-6520, DOI: 10.1039/C5SC00594A * |
| TAYLOR M JOAN, CHAUHAN KRISHAN P, SAHOTA TARSEM S: "Gels for constant and smart delivery of insulin", BRITISH JOURNAL OF DIABETES, ABCD (DIABETES CARE) LTD C/O RED HOT IRONS LTD, vol. 20, no. 1, pages 41 - 51, XP093061043, ISSN: 2397-6233, DOI: 10.15277/bjd.2020.248 * |
| XU YU; YUWEI HU; JASON S. KAHN; ALESSANDRO CECCONELLO; ITAMAR WILLNER: "Orthogonal Dual‐Triggered Shape‐Memory DNA‐Based Hydrogels", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 22, no. 41, 19 August 2016 (2016-08-19), DE, pages 14504 - 14507, XP071879588, ISSN: 0947-6539, DOI: 10.1002/chem.201603653 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023014293A2 (en) | 2023-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200601447A (en) | Rinsing composition, and method for rinsing and manufacturing silicon wafer | |
| AU2003262674A1 (en) | Active agent delivery system including a poly(ethylene-co-(meth)acrylate), medical device, and method | |
| EP1164167A4 (en) | Sealing composition and sealing method | |
| EP2031049A3 (en) | Chemical delivery product and process for making the same | |
| EP1334986A3 (en) | Hydrophobe-amine graft copolymer | |
| EP1781345A4 (en) | Immobilization of cells in a matrix formed by biocompatible charged polymers under laminar flow conditions | |
| AU3877200A (en) | Hydrogel-forming system with hydrophobic and hydrophilic components | |
| ATE276343T1 (en) | A WATER SOLUBLE OR WATER DISPERSIBLE POLYMER CLEANING AGENT CONTAINING | |
| DE50115774D1 (en) | DISPERSIBLE POLYMER POWDER | |
| WO2008086539A3 (en) | Compositions of ethylene/alpha-olefin multi-block interpolymer for elastic films and laminates | |
| AU590565B2 (en) | Controlled release delivery system for macromolecules | |
| NZ703820A (en) | Permeant delivery system and methods for use thereof | |
| BRPI0514178A (en) | coating composition, coating, and object coated with a coating composition | |
| EP1591846A3 (en) | Middle layer of die structure that comprises a cavity that holds an alkali metal | |
| ATE464888T1 (en) | DEVICE FOR TRANSDERMAL DELIVERY OF ACTIVE INGREDIENTS | |
| WO2006052285A3 (en) | Polymeric nanoparticles and nanogels for extraction and release of compounds | |
| NO20060084L (en) | Polyvinylbutyral foil with bifunctional surface modifier | |
| EP2114044A3 (en) | Apparatus and method for reducing the peak to average power ration of a preamble signal | |
| MX2010008945A (en) | Drug delivery system with stabilising effect. | |
| TW200628520A (en) | Composite film suitable as a donor support in a radiation-induced thermal transfer imaging process | |
| WO2023014293A3 (en) | A ph-responsive composition for facilitating delivery of a cargo and a method of encapsulating cargo with a ph-responsive composition | |
| WO2009094343A3 (en) | Amine-neutralized ionomer encapsulant layers and solar cell laminates comprising the same | |
| WO2005044904A3 (en) | Exfoliated polyolefin/clay nanocomposites using chain end functionalized polyolefin as the polymeric surfactant | |
| GB2583855A8 (en) | Transmucosal delivery device and method of manufacturing same | |
| GB2424516A (en) | Protecting thin semiconductor wafers during back-grinding in high-volume production |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NENP | Non-entry into the national phase |
Ref country code: DE |