WO2023004537A1 - 一种用于小鼠独立通气笼的光照节律干预装置 - Google Patents

一种用于小鼠独立通气笼的光照节律干预装置 Download PDF

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WO2023004537A1
WO2023004537A1 PCT/CN2021/108420 CN2021108420W WO2023004537A1 WO 2023004537 A1 WO2023004537 A1 WO 2023004537A1 CN 2021108420 W CN2021108420 W CN 2021108420W WO 2023004537 A1 WO2023004537 A1 WO 2023004537A1
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light
light source
rhythm
shading
cage
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PCT/CN2021/108420
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English (en)
French (fr)
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高亮
佘泓达
邓霞
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中国科学院深圳先进技术研究院
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Priority to PCT/CN2021/108420 priority Critical patent/WO2023004537A1/zh
Publication of WO2023004537A1 publication Critical patent/WO2023004537A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K15/00—Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
    • A01K15/02—Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals

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  • the application belongs to the technical field of neuromedicine, and in particular relates to a light rhythm intervention device for independent ventilation cages of mice.
  • Circadian rhythm is an important adaptation mechanism formed by organisms in response to the long-term evolution of the earth's diurnal environment.
  • the vast majority of organisms on earth are regulated by genes related to circadian rhythm, which profoundly affects all systems of organisms, such as cardiovascular, metabolic, endocrine, immune, nervous, and reproductive systems.
  • the body's internal rhythm regulation mechanism is synchronized with external factors such as light, temperature, and seasonal environment. If the external light time, wavelength, intensity and other environments change, it may cause biological circadian rhythm disorder, thereby causing dysfunction of various systems, and even inducing cancer or death. Therefore, the study of biological circadian rhythm is inseparable from the intervention of light conditions.
  • the realization of light condition intervention is inseparable from a set of effective and controllable light rhythm intervention device.
  • the present application provides a light rhythm intervention device for independent ventilation cages of mice, which can perform light rhythm intervention experiments under various light conditions on independent ventilation cages of mice at the same time, with high flexibility and low cost.
  • a lighting rhythm intervention device for independent ventilation cages of mice comprising a light-shielding cage and a light source module, wherein the inner cavity of the light-shielding cage can be used to accommodate independent ventilation cages of mice, and the light source module is arranged in the light-shielding cage internal;
  • the light source module includes a timing switch, a light intensity switch, and a light source assembly; the timing switch and the light intensity switch are electrically connected to the light source assembly, the timing switch is used to control the illumination duration of the light source assembly, and the light intensity switch Used to control the light intensity of the light source component.
  • the shading cage includes an airtight box made of shading cloth
  • a suture assembly is provided on a top surface or a side of the shading cage, and a shading cloth strip is provided on the inner wall of the top surface or side, and the shading cloth strip is located directly below the suture assembly to prevent light leakage from the suture assembly.
  • the technical solution adopted in the embodiment of the present application further includes: the side wall of the shading cage is further provided with an air port; and,
  • the air port is provided with a light-shielding sleeve.
  • the technical solution adopted in the embodiment of the present application further includes: a card pocket is provided on the inner wall of the other side wall of the shading cage, and the light source module is arranged in the card pocket.
  • the technical solution adopted in the embodiment of the present application further includes: the shading cover, the shading cloth strip and the shading sleeve are made of 210t polyester taffeta material sprayed with silver glue coating.
  • the technical solution adopted in the embodiment of the present application further includes: a light-shielding tape is also sealed at the suture needle opening outside the light-shielding cage.
  • the technical solution adopted in the embodiment of the present application further includes: the light source module further includes a wireless power supply for power supply.
  • the technical solution adopted in the embodiment of the present application further includes: the timing switch is a time relay.
  • the technical solution adopted in the embodiment of the present application further includes: the light intensity switch is an LED dimmer.
  • the technical solution adopted in the embodiment of the present application further includes: the light source assembly includes an LED lamp group with a total power ⁇ 10W.
  • the beneficial effect produced by the embodiment of the present application lies in that the light rhythm intervention device for the independent ventilation cage of the mouse in the embodiment of the application can be made according to the size of the independent ventilation cage of the mouse, and has high practicality.
  • the light intensity and light time of the light source components can be flexibly controlled through the timing switch and the light intensity switch, so as to realize the rhythm intervention experiment under different light conditions.
  • the invention is not limited by the site, does not need to add other experimental equipment that takes up space, and can be installed, disassembled and maintained flexibly, and the experimental groups of different mouse independent ventilation cages do not interfere with each other, greatly increasing the illumination for mouse independent ventilation cages
  • the rhythm intervention device is safe and flexible, and has low cost and can be used repeatedly.
  • FIG. 1 is a schematic structural view of an illumination rhythm intervention device for independent ventilation cages for mice according to an embodiment of the present application
  • FIG. 2 is a schematic structural diagram of a light source module according to an embodiment of the present application.
  • Figure 3 is a schematic diagram of the comparison of the energy behavior indicators of the tail suspension test between the normal group mice and the continuous dark mice rhythm intervention for 6 weeks.
  • Fig. 1 is a schematic structural diagram of the light rhythm intervention device for independent ventilation cages for mice according to the embodiment of the present application.
  • the light rhythm intervention device for independent ventilation cages for mice in the embodiment of the present application includes a light-shielding cage 10 and a light source module 20 .
  • the light-shielding cage 10 is an airtight box made of light-shielding cloth, and a top or side surface of the light-shielding cage 10 is provided with a suture assembly 11 that can be opened or closed for easy opening.
  • a side wall of the shading cage 10 is also provided with an air port (not shown), the number and position of the air port correspond to the ventilation openings on the independent ventilation cage of the mouse, and the air port is also provided with a light-shielding cuff 13, a light-shielding sleeve
  • the cover 13 is located on the outside of the shading cage 10, and is a hollow cylinder made of shading cloth, which is used to prevent light leakage from the stomata and not affect the normal ventilation of the mouse independent ventilation cage.
  • the inner wall of the other side wall of the shading cage 10 is also provided with a card pocket 14 for installing the light source module 20 .
  • the shading cloth used in the shading cage 10, the shading cloth strips 12 and the shading sleeve 13 is a 210t polyester taffeta material sprayed with silver glue coating, which can completely shading, waterproof and heat insulation at the same time.
  • the shape of the light-shielding cage 10 can be set according to the shape of the mouse independent ventilation cage, so as to achieve complete shielding of external ambient light.
  • the size of the shading cage 10, suture assembly 11, shading cloth strip 12, shading sleeve 13 and built-in card pocket 14 can be set according to the size of the mouse independent ventilation cage. In order to facilitate installation, the shading cage 10 should be slightly larger than the size of the independent ventilation cage for mice.
  • the size of the mouse independent ventilation cage is 403 ⁇ 165 ⁇ 172mm (width ⁇ depth ⁇ height), then the size of the shading cage 10 is preferably set to a closed cuboid of 405 ⁇ 167 ⁇ 176mm, the length of the suture assembly 11 is 405mm, and the shading cloth
  • the size of the strip 12 is 405 ⁇ 30mm, the inner diameter of the light-shielding sleeve 13 is 35mm, the outer diameter is 7mm, and the length is 4mm; the size of the card pocket 14 is 50 ⁇ 90mm.
  • the sewing component 11 is a zipper, and other components with a sewing function such as Velcro or buttons may also be used specifically.
  • the inner lining of the light-shielding sleeve 13 is made of elastic material, and the shape of the light-shielding sleeve 13 can also be set according to the shape of the ventilation port on the independent ventilation cage of the mouse, so as to achieve complete protection against the light from the external environment. shaded.
  • the suture needle opening outside the light-shielding cage 10 is further sealed with a light-shielding tape.
  • FIG. 2 is a schematic structural diagram of a light source module according to an embodiment of the present application.
  • the light source module 20 of the embodiment of the present application includes a wireless power supply 21, a timing switch 22, a light intensity switch 23 and a light source assembly 24; wherein, the wireless power supply 21 is electrically connected to the timing switch 22 and the light intensity switch 23 respectively, and the timing switch 22 and The light intensity switches 23 are electrically connected to the light source components 24 respectively.
  • the wireless power supply 21 is a 6V battery box, which is used to supply power to the light source assembly 24;
  • the timer switch 22 is a time relay, which is used to control the illumination time of the light source assembly 24;
  • the light intensity switch 23 is an LED dimmer, which is used to control the light source assembly 24
  • the light intensity wherein, the light intensity adjustment range is 0-1000 lumens, and the RGB (red, green, blue) color multi-spectrum or specific spectral band dimming of the light source assembly 24 can be realized.
  • the light source assembly 24 includes an LED light group with a total power of ⁇ 10W, which can reduce the thermal effect of the light source, thereby reducing the impact on the ambient temperature in the mouse independent ventilation cage, and reducing fire safety hazards caused by overheating.
  • the wireless power supply 21 adopts a battery box structure, which is small, light, does not take up space, and can be reused, which can reduce the complexity of wiring and potential fire hazards, and at the same time reduce the impact of sudden power failure on the light rhythm intervention experiment; Using the light intensity switch to control the light intensity can meet the needs of different experimental conditions.
  • the shading cage 10 is wrapped on the outside of the mouse independent ventilation cage that needs to be subjected to the light rhythm intervention experiment, and the light time and light intensity of the light source assembly 24 are controlled by the timer switch 22 and the light intensity switch 23, thereby simulating different light conditions. Diurnal variation in conditions.
  • the light rhythm intervention device for mouse independent ventilation cages in the embodiment of the present application can be made according to the size of mouse independent ventilation cages of different manufacturers and models, and has high practicability; it can be flexibly controlled by timing switches and light intensity switches The light intensity and light time of the light source components realize the light rhythm intervention experiment under different light conditions.
  • the invention is not limited by the site, does not need to add other experimental equipment that takes up space, and can be installed, disassembled and maintained flexibly, and the animal experiment groups in different mouse independent ventilation cages do not interfere with each other, greatly increasing the number of independent ventilation cages for mice.
  • the light rhythm intervention device is safe and flexible, and has low cost and can be used repeatedly.
  • the present invention can completely isolate the external environment light of the independent ventilated cage of the mouse, and the behavioral phenotype of the tail suspension experiment is obvious after the light rhythm of the animal is intervened, as shown in Fig. Schematic diagram of the comparison of energy (energy) behavioral indicators in the tail suspension test after 6 weeks of rhythmic intervention in dark) mice. After six weeks of constant darkness, the mice tended to expend more energy than the control group over the course of the experiment.

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  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

一种用于小鼠独立通气笼的光照节律干预装置，属于神经医学科学技术领域。包括：遮光笼罩（10）和光源模块（20），其中，遮光笼罩（10）的内部空腔能够用于容纳小鼠独立通气笼，光源模块（20）设置于遮光笼罩（10）的内部；光源模块（20）包括定时开关（22）、光照强度开关（23）以及光源组件（24）；定时开关（22）和光照强度开关（23）分别与光源组件（24）电连接，定时开关（22）用于控制光源组件（24）的光照时长，光照强度开关（23）用于控制光源组件（24）的光照强度。不受场地限制，具有较高的实用性，可以实现不同光照条件下的节律干预实验，且成本低，可反复使用。

Description

一种用于小鼠独立通气笼的光照节律干预装置 技术领域
本申请属于神经医学科学技术领域，特别涉及一种用于小鼠独立通气笼的光照节律干预装置。
背景技术
昼夜节律是生物为应对地球昼夜环境变化长期进化形成的一种重要适应机制。地球上绝大多数生物都受昼夜节律相关基因的调控，这种调控深刻作用于生物机体的所有系统，例如心血管、代谢、内分泌、免疫、神经、生殖系统等。生理条件下，机体内在节律调控机制同外界光照、温度、季节环境等因素相同步。如果外界的光照时间、波长、强度等环境发生改变，则可能造成生物昼夜节律紊乱，从而引起各个系统的功能紊乱，甚至诱发癌症或死亡。因此，生物昼夜节律的研究离不开对光照条件的干预。而实现光照条件的干预离不开一套行之有效和可控的光照节律干预装置。
发明内容
本申请提供了一种用于小鼠独立通气笼的光照节律干预装置，可以同时对小鼠独立通气笼进行多种光照条件下的光照节律干预实验，灵活性高且成本较低。
为了解决上述问题，本申请提供了如下技术方案：
一种用于小鼠独立通气笼的光照节律干预装置，包括遮光笼罩和光源模 块，其中，所述遮光笼罩的内部空腔能够用于容纳小鼠独立通气笼，所述光源模块设置于遮光笼罩的内部；
所述光源模块包括定时开关、光照强度开关以及光源组件；所述定时开关和光照强度开关分别与光源组件电连接，所述定时开关用于控制所述光源组件的光照时长，所述光照强度开关用于控制光源组件的光照强度。
本申请实施例采取的技术方案还包括：所述遮光笼罩包括由遮光布制成的密闭箱体；以及，
所述遮光笼罩的一个顶面或侧面上设有缝合组件，所述顶面或侧面的内壁还设有遮光布条，所述遮光布条位于缝合组件的正下方，用于防止缝合组件漏光。
本申请实施例采取的技术方案还包括：所述遮光笼罩的侧壁还设置有气口；以及，
所述气口设有遮光袖套。
本申请实施例采取的技术方案还包括：所述遮光笼罩另一侧壁的内壁设有卡袋，所述光源模块设置于所述卡袋内。
本申请实施例采取的技术方案还包括：所述遮光笼罩、遮光布条以及遮光袖套为喷涂银胶涂层的210t涤塔夫材质。
本申请实施例采取的技术方案还包括：所述遮光笼罩外侧的缝线针口处还密封有遮光胶带。
本申请实施例采取的技术方案还包括：所述光源模块还包括用于供电的无线式电源。
本申请实施例采取的技术方案还包括：所述定时开关为时间继电器。
本申请实施例采取的技术方案还包括：所述光照强度开关为LED调光器。
本申请实施例采取的技术方案还包括：所述光源组件包括总功率≤10W的LED灯组。
相对于现有技术，本申请实施例产生的有益效果在于：本申请实施例的用于小鼠独立通气笼的光照节律干预装置可根据小鼠独立通气笼的大小进行制作，具有较高的实用性；通过定时开关和光照强度开关灵活控制光源组件的光照强度和光照时间，实现不同光照条件下的节律干预实验。本发明不受场地限制，无需添置其它占用空间的实验设备，且灵活安装、拆卸及维修，不同小鼠独立通气笼的实验组间互不干扰，大大增加了用于小鼠独立通气笼的光照节律干预装置的安全性和灵活性，且成本低，可反复使用。
附图说明
图1为本申请实施例的用于小鼠独立通气笼的光照节律干预装置的结构示意图；
图2为本申请实施例的光源模块结构示意图；
图3为正常组小鼠与持续黑暗小鼠节律干预6周后悬尾实验能量行为指标的比较示意图。
具体实施方式
为了使本申请的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本申请进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本申请，并不用于限定本申请。
请参阅图1，是本申请实施例的用于小鼠独立通气笼的光照节律干预装置 的结构示意图。本申请实施例的用于小鼠独立通气笼的光照节律干预装置包括遮光笼罩10和光源模块20。其中，遮光笼罩10为由遮光布缝制而成的密闭箱体，遮光笼罩10的一个顶面或侧面上设有可以打开或闭合的缝合组件11，便于打开，缝合组件11的正下方还设有遮光布条12，遮光布条12的一侧固定在该顶面或侧面的内壁，用于防止缝合组件11的缝隙漏光。遮光笼罩10的一个侧壁上还设置有气口(图未示)，气口的数量以及位置与小鼠独立通气笼上的通气换气口相对应，该气口还设有遮光袖套13，遮光袖套13位于遮光笼罩10的外侧，为由遮光布缝制而成的中空圆柱体，用于防止气口漏光的同时，不影响小鼠独立通气笼正常通气换气。遮光笼罩10的另一个侧壁的内壁还设有卡袋14，卡袋14用于安装光源模块20。
进一步地，遮光笼罩10、遮光布条12以及遮光袖套13所使用的遮光布为喷涂银胶涂层的210t涤塔夫材质，可完全遮光，同时防水、隔热。遮光笼罩10的形状可根据小鼠独立通气笼的形状进行设定，以达到对外界环境光线的完全遮蔽。遮光笼罩10、缝合组件11、遮光布条12、遮光袖套13以及内置卡袋14的大小可根据小鼠独立通气笼的尺寸进行设置。为了便于安装，遮光笼罩10应略大于小鼠独立通气笼的尺寸，以市场上常见的泰尼百斯1145T/1285L型小鼠独立通气笼或泓腾科技0078型小鼠独立通气笼为例，该小鼠独立通气笼的尺寸为403×165×172mm(宽×深×高)，则遮光笼罩10的尺寸优选设置为405×167×176mm的密闭长方体，缝合组件11的长度为405mm，遮光布条12的尺寸为405×30mm，遮光袖套13的内径直径为35mm，外径为7mm，长度4mm；卡袋14的尺寸为50×90mm。
本申请实施例中，缝合组件11为拉链，具体也可采用魔术贴或扣子等其他具有缝合功能的组件。
本申请实施例中，遮光袖套13的内衬为松紧带材料，遮光袖套13的外形也可根据小鼠独立通气笼上通气换气口的形状进行设定，以达到对外界环境光线的完全遮蔽。
本申请实施例中，为了防止遮光笼罩10漏光，还在遮光笼罩10外侧的缝线针口处用遮光胶带进一步密封。
进一步地，如图2所示为本申请实施例的光源模块结构示意图。本申请实施例的光源模块20包括无线式电源21、定时开关22、光照强度开关23以及光源组件24；其中，无线式电源21分别与定时开关22和光照强度开关23电连接，定时开关22和光照强度开关23分别与光源组件24电连接。无线式电源21为6V电池盒，用于为光源组件24供电；定时开关22为时间继电器，用于控制光源组件24的光照时间；光照强度开关23为LED调光器，用于控制光源组件24的光照强度；其中，光照强度调节范围为0～1000流明，并可实现光源组件24的RGB(红绿蓝)彩色多光谱或特定光谱波段调光。光源组件24包括总功率≤10W的LED灯组，可以降低光源的热效应，从而降低对小鼠独立通气笼内环境温度的影响，并且减少温度过热造成的消防安全隐患。
本申请实施例中，无线式电源21采用电池盒结构，小巧轻便不占用空间，并可重复使用，可以减少排线复杂性和潜在消防隐患，同时减少突然断电对光照节律干预实验的影响；利用光照强度开关控制光照强度，可以适应不同实验条件的需求。
基于上述结构，将遮光笼罩10包裹在需要进行光照节律干预实验的小鼠独立通气笼的外侧，通过定时开关22和光照强度开关23控制光源组件24的光照时间以及光照强度，从而模拟出不同光照条件下的昼夜变化。
本申请实施例的用于小鼠独立通气笼的光照节律干预装置可根据不同厂 家、型号的小鼠独立通气笼的大小进行制作，具有较高的实用性；通过定时开关和光照强度开关灵活控制光源组件的光照强度和光照时间，实现不同光照条件下的光照节律干预实验。本发明不受场地限制，无需添置其它占用空间的实验设备，且灵活安装、拆卸及维修，不同小鼠独立通气笼内的动物实验组间互不干扰，大大增加了用于小鼠独立通气笼的光照节律干预装置的安全性和灵活性，且成本低，可反复使用。
本发明经过实验验证，可完全隔离小鼠独立通气笼的外界环境光照，动物光照节律干预后悬尾实验行为学表型明显，具体如图3所示，为正常组小鼠与持续黑暗(constant dark)小鼠节律干预6周后悬尾实验energy(能量)行为指标的比较示意图。在持续黑暗6周后，小鼠在实验过程中消耗的能量有高于对照组的趋势。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本申请。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本申请中所定义的一般原理可以在不脱离本申请的精神或范围的情况下，在其它实施例中实现。因此，本申请将不会被限制于本申请所示的这些实施例，而是要符合与本申请所公开的原理和新颖特点相一致的最宽的范围。

Claims (10)

  1. 一种用于小鼠独立通气笼的光照节律干预装置，其特征在于，包括遮光笼罩和光源模块，其中，所述遮光笼罩的内部空腔能够用于容纳小鼠独立通气笼，所述光源模块设置于遮光笼罩的内部；
    所述光源模块包括定时开关、光照强度开关以及光源组件；所述定时开关和光照强度开关分别与光源组件电连接，所述定时开关用于控制所述光源组件的光照时长，所述光照强度开关用于控制光源组件的光照强度。
  2. 根据权利要求1所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述遮光笼罩包括由遮光布制成的密闭箱体；以及，
    所述遮光笼罩的一个顶面或侧面上设有缝合组件，所述顶面或侧面的内壁还设有遮光布条，所述遮光布条位于缝合组件的正下方，用于防止缝合组件漏光。
  3. 根据权利要求2所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述遮光笼罩的侧壁还设置有气口；以及，
    所述气口设有遮光袖套。
  4. 根据权利要求3所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述遮光笼罩另一侧壁的内壁设有卡袋，所述光源模块设置于所述卡袋内。
  5. 根据权利要求1至4任一项所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述遮光笼罩、遮光布条以及遮光袖套为喷涂银胶涂层的210t涤塔夫材质。
  6. 根据权利要求5所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述遮光笼罩外侧的缝线针口处还密封有遮光胶带。
  7. 根据权利要求1所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述光源模块还包括用于供电的无线式电源。
  8. 根据权利要求7所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述定时开关为时间继电器。
  9. 根据权利要求7所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述光照强度开关为LED调光器。
  10. 根据权利要求1、7、8或9所述的用于小鼠独立通气笼的光照节律干预装置，其特征在于，所述光源组件包括总功率≤10W的LED灯组。
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