WO2023002397A1 - Dispositif d'oxygénothérapie nasale à flux intense automatique activé par l'ido - Google Patents
Dispositif d'oxygénothérapie nasale à flux intense automatique activé par l'ido Download PDFInfo
- Publication number
- WO2023002397A1 WO2023002397A1 PCT/IB2022/056691 IB2022056691W WO2023002397A1 WO 2023002397 A1 WO2023002397 A1 WO 2023002397A1 IB 2022056691 W IB2022056691 W IB 2022056691W WO 2023002397 A1 WO2023002397 A1 WO 2023002397A1
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- WIPO (PCT)
- Prior art keywords
- oxygen
- flow rate
- air
- patient
- high flow
- Prior art date
Links
- 238000002640 oxygen therapy Methods 0.000 title claims abstract description 58
- 239000001301 oxygen Substances 0.000 claims abstract description 74
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 74
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 65
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000011780 sodium chloride Substances 0.000 claims abstract description 5
- 230000033228 biological regulation Effects 0.000 claims abstract 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 28
- 230000036772 blood pressure Effects 0.000 claims description 14
- 229960004424 carbon dioxide Drugs 0.000 claims description 14
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 14
- 239000001569 carbon dioxide Substances 0.000 claims description 14
- 230000036387 respiratory rate Effects 0.000 claims description 11
- 229910001882 dioxygen Inorganic materials 0.000 claims description 8
- 238000009423 ventilation Methods 0.000 claims description 7
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 6
- 230000007423 decrease Effects 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 5
- 238000013021 overheating Methods 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 3
- 230000002706 hydrostatic effect Effects 0.000 claims description 3
- 230000000420 mucociliary effect Effects 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 238000013528 artificial neural network Methods 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 238000005399 mechanical ventilation Methods 0.000 description 6
- 238000013473 artificial intelligence Methods 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000023504 respiratory system disease Diseases 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 208000025721 COVID-19 Diseases 0.000 description 3
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000006213 oxygenation reaction Methods 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 201000004193 respiratory failure Diseases 0.000 description 3
- 238000002627 tracheal intubation Methods 0.000 description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 230000003190 augmentative effect Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
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- 230000006870 function Effects 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
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- 238000007789 sealing Methods 0.000 description 2
- 230000000153 supplemental effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000004852 Lung Injury Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010069363 Traumatic lung injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 206010001053 acute respiratory failure Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000516 lung damage Toxicity 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
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- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
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- 230000004202 respiratory function Effects 0.000 description 1
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Classifications
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Definitions
- the present invention relates to a system and method for providing augmented breathing. More specifically, the invention provides an automated IOT (Cellular/wifi/bluetooth) and AI (machine learning) enabled non-invasive respiratory support device providing high flow rate oxygen therapy for treating and supporting patients with respiratory disease while sensing vitals of a patient.
- IOT Cellular/wifi/bluetooth
- AI machine learning
- Respiratory support and ventilation therapies provide mechanical ventilation to the patients who require augmented breathing, and do so mechanically.
- Mechanical ventilation (MV) therapies require the patient to be inserted with a tracheal tube, or a sealing face or nasal mask or sealing nasal cannula. While helpful in supporting the breathing of a patient, it interfaces with mechanical ventilation, as it may be obtrusive and/or invasive to the user. Further, MV does not facilitate mobility therefore the patient needs to be sedentary and cannot perform activities that require mobility.
- Non-invasive ventilation exists as an alternative, which ventilates a patient with a face or nasal mask rather than requiring intubation, which can be an advantage in many situations.
- oxygen therapy There are various forms of oxygen therapy available which is judiciously administered to patients depending upon the severity of the respiratory disease.
- the most common form of oxygen therapy includes administering supplemental oxygen to the patient with a small bore nasal canula, using a metering device known as an oxygen conserver that releases the oxygen in boluses during a patient's inspiratory phase.
- Some oxygen therapy systems deliver mixtures of air and therapeutic gas. Such therapies are not considered as ventilation therapy or respiratory support, because it does not mechanically help in the work of breathing.
- HFOT high flow oxygen therapy
- the primary strategy for COVID- 19 patients is supportive care, including oxygen therapy for hypoxemic patients, in which high-flow nasal cannula (HFNC) has been reported to be effective in improving oxygenation.
- HFNC high-flow nasal cannula
- HFNC was proven to avoid intubation compared to conventional oxygen devices.
- a high-flow nasal cannula (HFNC) is commonly used in the management of hypoxic respiratory failure, and is associated with more ventilator-free days and lower mortality compared with standard oxygen therapy or non-invasive ventilation.
- High flow oxygen therapy allows administration of high flow gas that exceeds the patient's peak inspiratory flow, above 30 L/min in adults, heated to 37 °C and with a humidity of 100%.
- HFNC is not a mechanical ventilation system, but is more of a respiratory support system.
- the mechanisms of action of the HFNC are multiple, highlighting its ability to increase alveolar recruitment, improving the ventilatory pattern, generating a positive expiratory pressure (PEEP) and producing dead-space CO2 washout.
- PEEP positive expiratory pressure
- HFNC is a suitable choice for treatment of patients with severe or critical COVID-19 symptoms.
- HFNC can provide a specific positive end-expiratory pressure, which has a robust effect on mild to moderate type I respiratory failure and it can also provide adequately warmed and humidified gas through the nasal pharynx which reduces the metabolic work associated with gas conditioning. Moreover, HFNC can reduce the intubation rate and improve clinical prognosis in patients with acute respiratory failure.
- the oxygen flow rate is increased beyond standard LTOT, for example, above 10 LPM or 15 LPM.
- high flow therapies are reported as therapeutic and embraced by some clinicians while questioned by others because it involves unknown factors and arbitrary administration techniques.
- high pressured air is administered, the idea is to overcome the positive air pressures generated in the patients' airways and lungs due the lung damage and facilitate oxygenation.
- the features that affect the efficacy of the LTOT include cannula size, nare size, flow rate, and patients breathing rate. However, these variables are enough to keep many physicians from utilizing HFT as such systems required continuous monitoring and trained professionals for operating and maintenance.
- Air sterilization and filtration as most of these devices are used when the patient is immune-compromised, filtration and sterilization of external air is essential.
- the Pa02/Fi02 ratio is frequently used to determine the severity of lung injury in mechanically ventilated patients.
- the nonlinear relation between Pa02/Fi02 and Fi02 underlines the limitations describing the intensity of hypoxemia using Pa02/Fi02 and is thus of major importance for the clinician.
- the main object of the present invention is to provide an IOT and AI enabled high flow rate oxygen device that optimizes selection between the flow and Fi02, interpret the Pa02/Fi02 assessment via the sensors and the IOT enabled modules, show appropriate plug-in time, provide air sterilization and also filters the air.
- Yet another object of the present invention is to provide a system and method for respiratory user interface incorporating high flow rate oxygen therapy along with IOT connectivity for monitoring respiratory ratein a real-time dynamic working condition.
- Yet another object of the present invention is to provide a system and method for providing a respiratory user interface incorporating high flow rate oxygen therapy and disinfection of the inhaled air.
- Yet another object of the present invention is to provide a system for respiratory user interface incorporating high flow rate oxygen therapy that is easily portable, light weight and economical.
- Yet another object of the present invention is to provide a system that will automatically increase or decrease or maintain a specific flow rate and Fi02 based on the respiratory rate, blood pressure and oxygen saturation of the patient.
- Yet another object of the present invention is to provide a system which is automated and self-regulated for high flow nasal oxygen therapy.
- an IOT and AI enabled high flow rate oxygen therapy system for treating mild, moderate and severe grade of respiratory diseases.
- the system comprises of a housing that incorporates a front section and a back section fastened together.
- the front section has provisions for a touch display unit and plurality of buttons to operate the high flow rate oxygen therapy system.
- the front section has provisions for connecting ports to connect different online sensors such as, but not limited to like SpC>2 sensor, heart rate sensor, breathe rate sensor, etc.
- the front section also has a removable cover that in-house a humidification chamber for performing disinfection of incoming oxygen-air mixture.
- the back section holds an air filter to bring in atmospheric air into the system and a connector for oxygen gas supply with is also provided with gauge and a regulator.
- An oxygen concentration sensor is also provided in the oxygen gas supply line to measure real-time concentration of supplied oxygen.
- the system incorporates a high RPM motor connected to an air mixer unit consists on a housing having an impeller. Through air mixer unit, a suitable mixture of air-oxygen gas is supplied to the heating and humidification chamber and an air flow sensor is provided to calculate the flow rate to the IOT module that includes computing hardware for receiving one or more sensor signals from the one or more sensors.
- an AI module is provided that incorporates reinforced neural network comprises of multiple processors to perform several computation and run artificial intelligence algorithm based on the patient’s oxygen saturation, blood pressure, respiratory rate, etc. The temperature controlled and humidified air-oxygen gas mixture from system is then delivered to a patient through a connecting tube.
- the humidification chamber provided has its own temperature controlling system heating system that sets and adjusts air/oxygen mixture temperature at different temperatures.
- the humidification chamber has a removable pump to auto fill saline water in humidifier along with provisions like a float or level sensor which turn ON/OFF the removable suction pump as per the required level of water.
- the provided humidification chamber can automatically maintain the temperature and humidification of the air/oxygen mixture administered to the patient and is also equipped with an overheating prevention system, in order not to compromise patient treatment or damage equipment or its performance.
- the system provides distinct advantage as the deviceis automated, that provides non-invasive ventilation while sensing multiple vitals of a patient.
- the vital data received from the patient would be fed to the neural network algorithm of the main controlling processor and this data is then processed and classified into specific data categories.
- the data can be classified into various categories and the patient would be matched to a specific disease category. This will help the machine to learn the patient’s vital data such as blood pressure, respiratory rate, oxygen saturation, temperature, pulse rate etc, and measure the responses over time and adjust the oxygen flow rates, Fi02, air temperature and humidity specific to the patient in a way that would help the patient recover early.
- the system provides distinct advantage as the device provides high flow rate oxygen device that is optimized for making selection between the air and oxygen flow and Fi02, interpret the Pa02/Fi02 assessment via IOT and AI enabled modules, show appropriate plug-in time and provide air sterilization and filtration of the air.
- the system provides a module containing pulse oximeter, temperature sensor, inertial motion sensor, blood pressure module, electro-cardio gram (ECG) sensor, wifi and bluetooth modules.
- ECG electro-cardio gram
- the system will be provided with multiple buttons for different functions such as, but not limited to ON/OFF, adjustment of Fi02, flow rates, temperature, connecting to wifi, bluetooth, connect to phone app, etc.
- Fig. 1 illustrates a schematic view of respiratory user interface incorporating high flow rate oxygen therapy system according to the embodiments of the present invention
- Fig. 2 is a block diagram showing an example of the components of high flow rate oxygen therapy system according to the embodiments of the present invention
- Fig. 3a shows perspective view of the high flow rate oxygen therapy system according to the embodiments of the present invention
- Fig. 3b shows another perspective view of the high flow rate oxygen therapy system according to the embodiments of the present invention.
- Fig. 4 shows exploded perspective view of the high flow rate oxygen therapy system according to the embodiments of the present invention
- Fig. 5 shows sectional view of the high flow rate oxygen therapy system according to the embodiments of the present invention.
- Fig. 6 shows a flow chart describing working of the high flow rate oxygen therapy system according to the embodiments of the present invention.
- the present invention provides system and method for respiratory user interface incorporating high flow rate oxygen therapy for non-invasively treating various grades of respiratory disease.
- the system incorporates IOT connectivity for monitoring of multiple vitals of a patient such as, but not limited to respiratory rate, pulse rate, blood pressure, ECG, oxygen saturation, temperature, partial pressure of oxygen/fraction of inspired oxygen (PaCVFiCE), SpC> 2 , etc. in a real-time dynamic working environment.
- an AI module is provided that incorporates reinforced neural network comprises of multiple processors to perform several computation and run artificial intelligence algorithm based on the patient’s oxygen saturation, blood pressure, respiratory rate, etc.
- the automated IOT enabled high flow rate oxygen therapy system 100 is configured with an external oxygen supply 200 such as, medical oxygen tank, medical oxygen supply from the wall outlet or the medical gas pipeline in a hospital.
- the external oxygen supply 200 is an optional embodiment and the whole setup can be run with it or without it, customizable as per availability. In an embodiment, external oxygen supply 200 is often used to assist and supplement patients who have respiratory impairments that respond to supplemental oxygen for recovery or healing.
- the high flow rate oxygen therapy system 100 further has provision to provide natural air 300 which is sucked into the system through air pump incorporated into the system.
- the air/oxygen mixture from the system 100 will be transferred to a patient 400 using a nasal cannula 600 positioned at the nostrils of the patient.
- the nasal cannula 600 consists of a lightweight tube 500 which on one end splits into two prongs which are placed in the nostrils and from which a mixture of air and oxygen flows. The other end of the tube is connected to the high flow rate oxygen therapy system 100.
- the system 100 is provided with a detachable module 900 containing pulse oximeter, temperature sensor, inertial motion sensor, blood pressure sensing module, electro cardio gram (ECG) sensor, cellular, wifi and bluetooth modules.
- This said module 900 is connected via a long cable to the system 100.
- the system 100 typically provides an air/oxygen mixture at flow rates of 0 to 120 liters/minute (L/min) at temperature between 31-39° C. At this configuration, it is possible to provide a patient with F1O2 (percent oxygen in the inhaled 02/air mixture) of about 30-100% oxygen. Further, the system 100 has additional advantages as follows: wash out carbondioxide (CO2) retained in lungs; wash out nasopharyngeal carbondioxide (CO2); maintain mucociliary function; decreases anatomical dead space; provide positive airway pressure thus increases air-way calibers; increases end-expiratory transpulmonary pressure; anddecreases hydrostatic capillary-alveolar gradient.
- CO2 percentage oxygen in the inhaled 02/air mixture
- FIG. 2 is a block diagram showing an example of the components of high flow rate oxygen therapy system according to the embodiments of the present invention.
- the high flow rate oxygen therapy system can be coupled with plurality of attachments such as, but not limited to a heated humidifier unit, a flow sensor, a temperature sensor, IMU-Respiratory sensor, oxygen saturation sensor, blood pressure sensor, electro cardio gram (ECG) sensor, etc. All the attachments used are such that it can be easily be communicated with an IOT module of the high flow rate oxygen therapy system which have all the computing hardware such as microprocessor with their respective memory devices.
- the IOT module allows the recorded data to exchange over any other computing device such as, but not limited to laptop, tablet, mobile phone, etc.
- an AI module that incorporates reinforced neural network comprises of multiple processors to perform several computation and run artificial intelligence algorithm based on the patient’s oxygen saturation, blood pressure, respiratory rate, etc.
- a graphical user interface is provided with high flow rate oxygen therapy system in the form of touch-screen module which allows the remote operations associated with the high flow rate oxygen therapy system.
- FIG. 3a shows perspective view of the high flow rate oxygen therapy system 100 according to the embodiments of the present invention.
- the high flow rate oxygen therapy system 100 comprises of a front section 102 and a back section 104 fastened together.
- the front section 102 has provisions for a touch display unit 106 and plurality of buttons 108 to operate the high flow rate oxygen therapy system lOO.
- the touch display unit 106 is any standard LED display and shows different operations and configuration related to the system 100.
- the front section has provisions for connecting ports 110 to connect different online sensors such as, but not limited to like SpCE sensor, blood pressure sensor, electro cardio gram (ECG) sensor, heart rate sensor, respiratory rate sensor, etc.
- the front section 102 also has a removable cover 112 that in-house a humidification chamber 114 for performing disinfection of incoming oxygen-air mixture.
- the back section 104 holds an air filter 116 to bring in atmospheric air into the system 100. Further, a motorized valve connector 118 with gauge 120 and a regulator 122 is provided for oxygen gas supply.
- FIG. 3b shows another perspective view of the high flow rate oxygen therapy system 100 according to the embodiments of the present invention.
- an outlet 124 is provided that transfers highly disinfected and right metered air/oxygen mixture to a patient using a nasal cannuala fixed at the nostrils of the patient.
- a port 126 to insert power a cord is provided along with a LAN port 128 to connect the system 100 to the internet.
- Fig. 4 shows exploded perspective view of the high flow rate oxygen therapy system 100 according to the embodiments of the present invention.
- the removable cover 112 is removed from the cavity provided in the front section 102 to expose the in-built humidification chamber 114 with its heating system 132 that sets and adjust air/oxygen mixture temperature at different temperatures.
- the humidification chamber 114 comprises of a container unit 130 having atleast one inlet 134 and outlet 136 connections and has a removable pumpl38 to auto fill saline water in humidification chamber 114. Once temperature is set by the user, the humidification chamber 114 automatically maintains the temperatures of the air/oxygen mixture administered to the patient and also equipped with an overheating prevention system, in order not to compromise patient treatment or damage equipment or its performance.
- the humidification chamber 114 has provisions like a float or level sensor which turn ON/OFF the removable suction pump 138 as per the required level of water.
- FIG. 5 shows sectional view of the high flow rate oxygen therapy system 100 according to the embodiments of the present invention.
- An oxygen concentration sensor 140 is provided on oxygen gas supply line 142 to measure real-time concentration of supplied oxygen.
- the system 100 incorporates an air mixer unit 144 consists on a housing having an impeller into it connected with a high RPM motor. Through air mixer unit 144 a suitable mixture of air-oxygen is supplied into the humidification chamber 114 and a flow sensor 146 is provided at the outlet connection 124 to measure and forward the flow rate to the central processing unit 148.
- the central processing unit 148 includes an IOT module incorporating computing hardware for receiving one or more sensor signals from the one or more sensors. Further, an AI module is provided that incorporates reinforced neural network comprises of multiple processors to perform several computation and run artificial intelligence algorithm based on the patient’s oxygen saturation, blood pressure, respiratory rate, etc.
- the computing hardware further includes a wireless network interface such as, but not limited to WIFI, bluetooth, radiofrequency or implemented as a cellular modem, for example complying with contemporary, GSM and/or 3G communication standards and includes one or more physical memory devices, each of which can be a type of random access memory (RAM), such as dynamic RAM (DRAM) or static RAM (SRAM), read-only memory (ROM), which may be programmable, such as flash memory, or any combination thereof.
- RAM random access memory
- DRAM dynamic RAM
- SRAM static RAM
- ROM read-only memory
- the computing hardware is programmed to send information corresponding to the one or more sensor signals in a constant manner.
- the computing hardware is further configured to perform real-time or intermittent monitoring data processed through multiple monitoring sensors in the cloud connected systems which can be further sent remotely to user assistance or care taker on their smart devices such as, but not limited to mobiles, laptop, computer, etc.
- a medical oxygen supply will be attached to the high flow rate oxygen therapy system and its concentration will be checked. If oxygen concentration is above or below a certain percentage then its flow will be adjusted before it will be sent to the air mixer unit.
- patient vitals are monitored by plurality of sensor provided with the high flow rate oxygen therapy system and their data is forwarded to AI module for computing.
- AI module for computing.
- the air-oxygen mixture will be send to the humidification chamber which automatically maintains the temperatures of the air- oxygen mixture administered to the patient.
- its flow rate will be calculated by a flow sensor provided at the outlet.
- patient vitals will be monitored continually and the computing hardware of AI module will automatically control the flow rate employing reinforced neural network / artificial intelligence algorithm based on the patient’s oxygen saturation, blood pressure, respiratory rate, etc.
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Abstract
La présente invention concerne un système d'oxygénothérapie à haut débit d'écoulement activé par l'IDO et l'IA 100 et un procédé, la régulation du débit d'écoulement étant automatiquement commandée par le module d'IA en fonction des signes vitaux du patient; le mélange air-oxygène de sortie s'écoule à une vitesse de 0 à 120 litres par minute (L/min) à une température comprise entre 31 et 39 ºC; le système fournit au patient une FiO2 d'environ 30 à 100 % d'oxygène; et la chambre d'humidification 114 comporte une pompe amovible pour remplir automatiquement de l'eau salée avec des dispositions tels qu'un flotteur ou un capteur de niveau qui met en marche/arrêt la pompe amovible selon le niveau requis d'eau.
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CN116474233A (zh) * | 2023-06-25 | 2023-07-25 | 斯莱达医疗用品(惠州)有限公司 | 一种医用湿化器输出量高精度控制方法、系统及介质 |
Citations (2)
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US7222624B2 (en) * | 2004-07-02 | 2007-05-29 | Praxair Technology, Inc. | Dual sensor oxygen therapy device |
IN202141026373A (fr) * | 2021-06-14 | 2021-07-02 | V Nagajothi Dr. |
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- 2022-07-20 WO PCT/IB2022/056691 patent/WO2023002397A1/fr unknown
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US7222624B2 (en) * | 2004-07-02 | 2007-05-29 | Praxair Technology, Inc. | Dual sensor oxygen therapy device |
IN202141026373A (fr) * | 2021-06-14 | 2021-07-02 | V Nagajothi Dr. |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN116474233A (zh) * | 2023-06-25 | 2023-07-25 | 斯莱达医疗用品(惠州)有限公司 | 一种医用湿化器输出量高精度控制方法、系统及介质 |
CN116474233B (zh) * | 2023-06-25 | 2023-08-22 | 斯莱达医疗用品(惠州)有限公司 | 一种医用湿化器输出量高精度控制方法、系统及介质 |
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