WO2023000433A1 - Système de traitement de signal - Google Patents

Système de traitement de signal Download PDF

Info

Publication number
WO2023000433A1
WO2023000433A1 PCT/CN2021/114434 CN2021114434W WO2023000433A1 WO 2023000433 A1 WO2023000433 A1 WO 2023000433A1 CN 2021114434 W CN2021114434 W CN 2021114434W WO 2023000433 A1 WO2023000433 A1 WO 2023000433A1
Authority
WO
WIPO (PCT)
Prior art keywords
signal
optical fiber
stimulation
target
target site
Prior art date
Application number
PCT/CN2021/114434
Other languages
English (en)
Chinese (zh)
Inventor
刘雪
王枫
王立平
Original Assignee
中国科学院深圳先进技术研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 中国科学院深圳先进技术研究院 filed Critical 中国科学院深圳先进技术研究院
Publication of WO2023000433A1 publication Critical patent/WO2023000433A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the embodiments of the present application relate to the field of signals, and in particular, to a signal processing system.
  • Neuromodulation technology enables the reversible regulation of central, peripheral, or autonomic nervous system activity using implantable or non-implantable technologies.
  • Many forms of neuromodulation can be used to modulate brain function, such as transcranial electrical stimulation, optogenetics, infrared neurostimulation, etc.
  • infrared nerve stimulation is generally considered to be photothermal effect, that is, infrared light is absorbed by water to generate heat, and sudden changes in temperature generate transmembrane capacitive currents on cells or activate heat-sensitive ion channels, affecting the electrical activity of nerve cells.
  • photothermal effect that is, infrared light is absorbed by water to generate heat, and sudden changes in temperature generate transmembrane capacitive currents on cells or activate heat-sensitive ion channels, affecting the electrical activity of nerve cells.
  • excessive photothermal effects often cause damage to cells and tissues, so there are limitations in the role of infrared nerve stimulation.
  • transcranial electrical stimulation, optogenetic technology, and infrared nerve stimulation in related technologies cannot provide a precise and low-risk regulation device.
  • the embodiment of the present application provides a signal processing system to improve the targeting and adjustability of stimulation signals and reduce the risk of stimulation.
  • An embodiment of the present application provides a signal processing system, including: a signal processing device, an optical fiber device, and a data processing module, the signal processing device is respectively connected to the optical fiber device and the data processing module, wherein:
  • the signal processing device is configured to generate a stimulation signal, and introduce the stimulation signal into a target site through the optical fiber device, so as to stimulate the target site;
  • the signal processing device is also configured to receive an activity signal and transmit the activity signal to the data processing module, wherein the activity signal is a signal obtained after stimulating the target site;
  • the data processing module is configured to receive the activity signal output by the signal processing device, and convert the activity signal into a target digital signal.
  • FIG. 1 is a schematic structural diagram of a signal processing system provided in Embodiment 1 of the present application;
  • FIG. 2 is a schematic structural diagram of a signal processing system provided in Embodiment 2 of the present application.
  • Fig. 3 is a schematic diagram of a nasal neuroendoscope guiding optical fiber into the cranium provided by Embodiment 2 of the present application;
  • Fig. 4 is a schematic diagram of entering the cranium through the foramen ovale through the exit of the trigeminal nerve provided by the second embodiment of the present application;
  • Fig. 5 is a schematic diagram of a method provided in Example 2 of the present application to enter the brain through the middle ear and through the tympanic cavity.
  • FIG. 1 is a schematic structural diagram of a signal processing system provided in Embodiment 1 of the present application.
  • the signal processing system provided in this embodiment can be used for three-dimensional visual cognition function tests of primates.
  • the signal processing system includes a signal processing device 20, an optical fiber device 10 and a data processing module 30, wherein:
  • the signal processing device 20 is configured to generate a stimulation signal, and introduce the stimulation signal into a target site through the optical fiber device 10, so as to stimulate the target site;
  • the signal processing device 20 is further configured to receive an activity signal and transmit the activity signal to the data processing module 30, wherein the activity signal is a signal obtained after stimulating the target site;
  • the data processing module 30 is configured to receive the activity signal output by the signal processing device 20, and convert the activity signal into a target digital signal.
  • the optical fiber device 10 is used to introduce the stimulation signal to the target site to improve the targeting of the stimulation signal.
  • the stimulation signal is generated by the signal processing device 20, and the nerve stimulation probe (such as the optical fiber imaging and stimulation probe 7 in FIG. 2 ) is accurately implanted into the target site through the optical fiber device 10, so as to realize the imaging and regulation of the target site .
  • the activity signal of the target site after stimulation is received by the signal processing device 20, and the activity signal is output to the data processing module 30, and the data processing module 30 converts the activity signal into a target digital signal and then analyzes it to realize the target site.
  • Stimulus state analysis The analysis method may adopt a data analysis method in related technologies.
  • the activity signal is an analog signal.
  • the signal processing device 20 may be at least one signal processing device, and may be set according to actual needs.
  • the signal processing device 20 can process at least one signal such as electromagnetic signal, electrical signal, and acoustic wave signal.
  • the signal processing device 20 can process multiple signals, it can realize stimulation of different types of signals at the target site.
  • the signal processing system includes: a signal processing device 20, an optical fiber device 10, and a data processing module 30, and the signal processing device 20 is respectively connected to the optical fiber device 10 and the data processing module 30, wherein: the The signal processing device 20 is configured to generate a stimulation signal, and introduce the stimulation signal into a target site through the optical fiber device 10, so as to stimulate the target site; the signal processing device 20 is also configured to receive an activity signal, and transmit the activity signal to the data processing module 30, wherein the activity signal is a signal obtained after stimulating the target site; the data processing module 30 is configured to receive the signal processing device 20 output activity signal, and convert the activity signal into a target digital signal.
  • the targeting and adjustability of the stimulation signal are improved, and the risk of stimulation is reduced.
  • the optical fiber device 10 includes an optical fiber input end 101 and an optical fiber output end 102, wherein:
  • the optical fiber input end 101 is configured to receive the stimulation signal
  • the optical fiber output end 102 is configured to introduce the target band optical stimulation signal corresponding to the stimulation signal into the target site.
  • the optical fiber input end 101 is connected to the signal processing device 20, the optical fiber input end 101 is set to receive the stimulation signal output by the signal processing device 20, and the optical fiber output end 102 introduces the target band optical stimulation signal corresponding to the stimulation signal into the target site, so as to realize Stimulation of the target site.
  • a bevel angle of Brewster's angle can be set at the fiber input end 101.
  • the polarization direction of the incident light is parallel to the incident plane, the coupling efficiency is optimal.
  • the specifications of the optical fiber can be set according to actual needs. For example, if the target component is the brain, considering the different ways of entering the brain, there are also differences in the brain area of the targeted therapy. Different specifications of the optical fiber can be selected according to the size of the targeted brain area. For example, when A fiber with a larger numerical aperture can be used when targeting a large brain area, while a fiber with a smaller numerical aperture can be used when targeting a small brain area.
  • the signal processing device 20 includes an electromagnetic wave source 1 and an electromagnetic wave adjusting device, wherein:
  • the electromagnetic wave source 1 is configured to generate an original electromagnetic pulse of a set band
  • the electromagnetic wave adjustment device is configured to adjust the original electromagnetic pulse and generate a fiber transmission signal as the stimulation signal.
  • electromagnetic waves can be used as stimulation signals, optical fiber transmission signals are generated based on the electromagnetic waves, and the optical fiber transmission signals are transmitted to the target site through the optical fiber device 10 .
  • Terahertz waves are electromagnetic waves with a frequency range of 0.1 terahertz to 10 terahertz and a wavelength of 0.03 millimeters to 3 millimeters, which is between microwave and infrared bands.
  • Terahertz waves are highly sensitive to interstitial water, cell density, and spatial arrangement of cells. Therefore, terahertz spectroscopy can be used to observe the difference between the water content in tumor tissue and normal cells, and to judge the development of tumors.
  • the stimulation signal can be an electromagnetic signal of a set band, that is, the original electromagnetic pulse of the set band is generated by the electromagnetic wave source 1, and the original electromagnetic pulse generated can be a high-frequency electromagnetic pulse from the mid-infrared band to the terahertz band.
  • the properties of Hertzian waves enable imaging and modulation of target sites.
  • the frequency of mid-infrared light belongs to the frequency range of chemical bond vibration, and nonlinear resonance may occur inside biomolecules, resulting in drastic changes in the conformation and function of biomolecules, causing non-thermal effects on biological systems, and reducing to a greater extent the damage caused by nerve stimulation. of tissue damage.
  • the regulation of neuron activity through mid-infrared nerve stimulation will not cause side effects such as thermal effects on brain tissue, and the regulation of neurons is reversible, with lower risks.
  • the adjustable frequency range of the electromagnetic wave source 1 is 5 micrometers to 11 micrometers, the maximum pulse width is 500 nanoseconds, and the maximum repetition frequency is 100 kilohertz, so as to realize the emission of precise original electromagnetic pulses.
  • the electromagnetic wave adjustment device includes a beam shaping unit 2, a three-dimensional fine-tuning platform 4 and a fiber coupler 3, wherein:
  • the beam shaping unit 2 is configured to shape the original electromagnetic pulse, and focus the shaped signal to the optical fiber input end 101;
  • the three-dimensional fine-tuning platform 4 is used to fix the fiber coupler 3 and align the fiber input end 101 with the light spot;
  • the fiber coupler 3 is used to fix the fiber input end 101 .
  • the original electromagnetic pulse can be adjusted by means of beam shaping and light spot fine-tuning, so as to generate optical fiber transmission signals that meet requirements.
  • the beam shaping can be realized by the beam shaping unit 2.
  • the beam shaping unit 2 can shape and focus the original electromagnetic pulse, so that the original electromagnetic pulse can be shaped, and the shaped signal can be focused and transmitted to the optical fiber input end 101.
  • the optical fiber input end 101 can be fixed on On the optical fiber coupler 3, the optical fiber coupler 3 is installed on the three-dimensional fine-tuning platform. When the optical fiber coupler 3 is installed, the optical fiber input end 101 and the light spot can be fine-tuned and aligned first, so that the original electromagnetic pulse can be smoothly transmitted to the optical fiber input end 101. .
  • the transmittance of the beam shaping unit 2 is higher than the set threshold, and the beam shaping unit 2
  • the shaping unit 2 is arranged at a preset distance from the exit of the electromagnetic wave source 1 .
  • the beam shaping unit 2 includes an optical fiber, and the optical fiber of the beam shaping unit 2 has an inner diameter between 9 microns and 12 microns, an outer diameter of 170 microns, a numerical aperture of 0.3, and an effective waveband of 1.5 microns to 9.5 microns. mode fiber. It can be understood that the transmittance of the beam shaping unit 2 to the target wavelength band is determined by the material of the beam shaping unit 2 .
  • the beam shaping unit 2 is made of a material whose transmittance to high-frequency electromagnetic pulses in the mid-infrared to terahertz band is higher than a preset threshold, and is capable of focusing.
  • the beam shaping unit 2 is arranged 3 centimeters from the exit of the electromagnetic wave source 1 (for example, a frequency-tunable high-frequency electromagnetic wave source), so that the effect of the beam shaping unit 2 can be optimized.
  • the optical fiber of the beam shaping unit 2 can adopt a multimode optical fiber with an inner diameter of 9 microns-12 microns, an outer diameter of 170 microns, a numerical aperture of 0.3 microns, and an effective waveband of 1.5 microns-9.5 microns.
  • Multimode fiber is an optical fiber that allows multiple guided mode transmissions. Due to the large core diameter of multimode fiber, it can allow different modes of light to be transmitted on one fiber.
  • the beam shaping unit 2 is used to shape the laser beam, and the structure of the beam shaping unit 2 may include a high-power laser diode and a mirror.
  • the three-dimensional fine-tuning platform 4 (that is, the multi-dimensional fine-tuning platform) includes a fine-tuning frame, and the fine-tuning frame includes horizontal rotation, overall horizontal displacement, overall vertical displacement, coupler horizontal displacement, and coupler vertical displacement. at least one mode of adjustment.
  • the fine-tuning frame of the multi-dimensional fine-tuning platform can be set to support fine-tuning in various adjustment modes.
  • the fine-tuning frame is used to install the fiber coupler 3 and fine-tune the alignment between the fiber input end 101 and the light spot.
  • the fine-tuning frame can change the position of the fiber input end 101 , and can also shift the whole fine-tuning frame or only the optical fiber coupler 3 .
  • the overall vertical displacement refers to the overall displacement fine-tuning frame
  • the horizontal displacement of the coupler refers to the displacement of the fiber coupler 3 only in the horizontal direction
  • the horizontal rotation refers to the horizontal rotation of the fiber input end 101 only.
  • the fine-tuning frame can be set to include five adjustment methods including horizontal rotation, overall horizontal displacement, overall vertical displacement, coupler horizontal displacement, and coupler vertical displacement.
  • the fine-tuning step size of each dimension can be adjusted according to actual needs. It is set, for example, that the fine-tuning step of each dimension may be 0.1 mm.
  • the signal processing system further includes an acoustic wave stimulator 5, and the acoustic wave stimulator 5 is respectively connected to the optical fiber device 10 and the data processing module 30, wherein:
  • the acoustic wave stimulator 5 is configured to generate a target acoustic wave signal, and introduce the target acoustic wave signal into a target site through the optical fiber device 10, so as to stimulate the target site.
  • the sonic stimulator 5 is configured to provide sonic waves of different frequencies and intensities, generate target sonic signals of set frequencies and set intensities, and introduce the target sonic signals through the optical fiber device 10 into the target site for stimulation.
  • the signal processing device 20 receives the activity signal generated by the target site after stimulation, and outputs the activity signal to the data processing module 30, and the data processing module 30 converts the activity signal into a target digital signal and then analyzes it, so as to realize the stimulation state of the target site analyze.
  • the analysis method may adopt a data analysis method in related technologies.
  • the sound wave stimulator 5 may include a sound wave controller and a frequency controller, and may be embodied as an acoustic stimulation system with various frequencies and sound intensities, and the corresponding frequencies and sound intensities may be customized as required.
  • the signal processing system further includes an electrical stimulator 6, and the electrical stimulator 6 is respectively connected to the optical fiber device 10 and the data processing module 30, wherein:
  • the electrical stimulator 6 is configured to generate a target electrical signal, and introduce the target electrical signal into a target site through the optical fiber device 10, so as to stimulate the target site.
  • the electric stimulator 6 is set to generate direct current stimulation.
  • the electric stimulator 6 may include direct current electrodes for stimulating brain regions and a control circuit for controlling the stimulation current on the direct current electrodes.
  • the preset stimulation current polarity, intensity, duration and sequence; after the electrical stimulator 6 generates the target electrical signal, the target electrical signal is introduced into the target site through the optical fiber device 10 for stimulation, and the signal processing device 20 receives the activity generated by the target site after stimulation signal, and output the activity signal to the data processing module 30, and the data processing module 30 converts the activity signal into a target digital signal for analysis, so as to realize the analysis of the stimulation state of the target site.
  • the analysis method may adopt a data analysis method in related technologies.
  • the data processing module 30 may include a data collection module and a processor 8, the data collection module is configured to receive the activity signal transmitted by the optical fiber device 10, and the processor 8 is configured to receive the activity signal received by the data collection module. signal, and convert the activity signal into a digital signal, and output the digital signal to the computer 40 for data processing and analysis.
  • FIG. 2 is a schematic structural diagram of a signal processing system provided in Embodiment 2 of the present application. This embodiment is based on the above-mentioned embodiments.
  • the target site may be a brain site, and the embodiments of the present application may stimulate and detect the brain site.
  • high-frequency electromagnetic pulses in the terahertz band are used to image and detect brain lesion tissue, and combined with mid-infrared band neural stimulation to regulate neuron activity and improve brain function.
  • This method does not require craniotomy, and minimizes the damage and psychological stress caused by surgical operations, and the mid-infrared band nerve stimulation is reversible, and the stimulation will not cause thermal effects, so it will not cause cell damage, and the risk is low.
  • xyz represents a spatial coordinate system
  • the signal processing system includes an electromagnetic wave source 1 (such as a frequency-tunable high-frequency electromagnetic wave source) 1, a beam shaping unit 2, a fiber coupler 3, a multi-dimensional fine-tuning platform (such as a three-dimensional fine-tuning platform ) 4, acoustic wave stimulator 5, electrical stimulator 6, optical fiber imaging and stimulation probe 7 and processor 8. in:
  • the electromagnetic wave source 1 is set to generate high-frequency electromagnetic pulses
  • the beam shaping unit 2 is configured to shape the high-frequency electromagnetic pulse generated by the frequency-tunable high-frequency electromagnetic wave source, and focus the shaped signal to the optical fiber input end 101;
  • Fiber coupler 3 used to fix the fiber input end 101
  • the three-dimensional fine-tuning platform 4 is used for fine-tuning and aligning the optical fiber input end 101 and the light spot;
  • the sound wave stimulator 5 is configured to provide sound waves of different frequencies and intensities
  • the electric stimulator 6 is set to generate direct current stimulation
  • the optical fiber imaging and stimulation probe 7 is configured to receive high-frequency electromagnetic pulses, and introduce high-frequency electromagnetic pulses into the brain nervous system through the optical fiber output end 102;
  • the processor 8 is configured to receive the change signal of brain activity after optical, acoustic or electrical stimulation, convert the change signal into a digital signal, and output the digital signal to the computer 40 .
  • High-frequency electromagnetic signals, acoustic signals and/or electrical signals are accurately introduced into the nervous system through optical fiber systems to achieve minimally invasive, highly targeted and efficient regulation and enhancement of specific brain regions to diagnose and treat brain diseases.
  • the frequency-tunable high-frequency electromagnetic wave source can generate high-frequency electromagnetic pulses in the mid-infrared band to the terahertz band.
  • the repetition frequency is 100 kHz;
  • the beam shaping unit 2 is made of a material whose transmittance to high-frequency electromagnetic pulses in the mid-infrared to terahertz band is higher than a preset threshold and can be focused.
  • the beam shaping unit 2 is arranged at 3 centimeters from the outlet of the frequency-tunable high-frequency electromagnetic wave source.
  • the optical fiber adopts a multimode optical fiber with an inner diameter of 9 microns to 12 microns, an outer diameter of 170 microns, a numerical aperture of 0.3 microns, and an effective waveband of 1.5 microns to 9.5 microns; the fiber input end 101 has a beveled Brewster angle , when the polarization direction of the incident light is parallel to the incident plane, the coupling efficiency is optimal.
  • the fiber optic coupler 3 is used to fix the fiber input end 101 on the fiber optic coupler 3 through the knob; the three-dimensional fine-tuning platform is used to fix the fiber optic coupler 3 and align the fiber input end 101 with the light spot fine-tuning, three-dimensional
  • the three-dimensional fine-tuning platform includes a fine-tuning frame, and the fine-tuning frame includes five adjustment methods including horizontal rotation, overall horizontal displacement, overall vertical displacement, coupler horizontal displacement, and coupler vertical displacement, and the fine-tuning step size of each dimension is 0.1 mm.
  • the middle section of the optical fiber is provided with a rubber sleeve to protect the optical fiber and strengthen the mechanical structure of the optical fiber; the end of the optical fiber is stripped of the rubber sleeve to expose the bare fiber for easy positioning; the end of the optical fiber is in a cut state, and the cut surface is smooth and flat;
  • Stimulator, electrical stimulator 6, provide frequency-adjustable acoustic or electrical stimulation system; Sonic frequency stimulator, comprises sound wave controller and frequency controller, and the sound wave frequency stimulator can be the acoustic wave that has multiple different frequencies and sound intensity The stimulation system can customize the acoustic stimulation source with corresponding frequency and sound intensity as required; the electric stimulator 6 includes a DC electrode for stimulating the brain area and a control circuit for controlling the stimulation current on the DC electrode, and the output of the control circuit is based on the stimulation target.
  • the optical fiber stimulation probe is used to receive the high-frequency electromagnetic pulse through the optical fiber input end 101, and introduce the mid-infrared band optical stimulation signal through the optical fiber output end 102 Brain nervous system.
  • the brain area of the targeted therapy is also different. According to the size of the targeted brain area, different specifications of optical fibers can be selected. When the target brain area is small, an optical fiber with a smaller numerical aperture is used. In addition, the duration and intensity of stimulation in the mid-infrared band can be adjusted according to the state and characteristics of the stimulation object.
  • the computer 40 can control the signal processing device 20 to generate stimulation signals, control the acoustic wave stimulator 5 to generate target acoustic wave signals, and control the electrical stimulator 6 to generate target electrical signals.
  • the signal processing system can also include a frequency generator device, which also includes a microscope and computer equipment (such as a computer 40) for data collection.
  • a frequency generator device which also includes a microscope and computer equipment (such as a computer 40) for data collection.
  • the end of the optical fiber, tissue samples, etc. can be analyzed under the microscope Position adjustment, adjusting the distance between the stimulating probe at the end of the optical fiber and the tissue sample, so that the stimulating signal output by the optical fiber can play a role in nerve regulation.
  • the stimulating probe at the end of the optical fiber can perform the function of neuromodulation within 20 mm from the tissue sample.
  • fiber optic probes can also be inserted into the brain through part of the physiological structure, and then inserted into the brain through neuroendoscopy (such as nasal neuroendoscopy) and puncture.
  • the fiber optic probe can be guided through the nasal neuroendoscope to enter the cranium, enter the cranium through the foramen ovale exiting the trigeminal nerve through puncture, enter the cranium through the middle ear and the tympanic cavity, etc.
  • Figure 3 is the second embodiment of the application A schematic diagram of a transnasal neuroendoscope guiding an optical fiber into the cranium is provided. Fig.
  • Fig. 4 is a schematic diagram of a method provided in Example 2 of the present application to enter the cranium through the foramen ovale exiting the trigeminal nerve.
  • Fig. 5 is a schematic diagram of a method provided in Example 2 of the present application to enter the brain through the middle ear and through the tympanic cavity.
  • the above-mentioned introduction method is based on the continuous development of endoscopic technology and the continuous accumulation of clinical experience. It does not require craniotomy, minimizes surgical trauma, and increases the possibility of long-term indwelling and long-term treatment.
  • the above three methods are used to stimulate the brain nerves in different brain regions according to different approaches.
  • the transnasal approach can be used to stimulate the cranial nerves in the sella region, which has a certain therapeutic effect on brain diseases in the sella region.
  • the foraminal approach is used to stimulate the brainstem nerves and has a certain therapeutic effect on brainstem brain diseases. It can be used to stimulate the temporal lobe cranial nerves through the middle ear and enter the brain through the tympanic cavity, which has certain therapeutic effects on temporal lobe brain diseases.
  • the embodiment of the present application provides a frequency generator device for brain stimulation, through the nose, foramen ovale or middle ear and other physiological structures, without craniotomy, into the brain through neuroendoscopy and puncture, which is implantable Technology, reversible regulation of brain activity, no need for craniotomy, less trauma, can leave the optical fiber in the brain for a long time without affecting the daily activities of the stimulated subject; and combine two imaging and treatment methods of terahertz technology and mid-infrared band stimulation , the neurostimulation probe is accurately implanted in the diseased brain area, which can perform early imaging diagnosis of the diseased brain area and treat brain diseases by regulating neural activity.
  • acoustic wave stimulators and electrical stimulators can be used according to different scenarios (such as combined with craniotomy) to give acoustic, optical or electrical stimulation to achieve better results.
  • the signal processing system may include an electrical stimulator, an acoustic wave stimulator, and an electromagnetic wave source, all of which are a frequency generator device for brain stimulation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

Est divulgué dans les modes de réalisation de la présente demande un système de traitement de signal. Le système comprend : un dispositif de traitement de signal, un dispositif fibre optique et un module de traitement de données, le dispositif de traitement de signal étant respectivement connecté au dispositif fibre optique et au module de traitement de données ; le dispositif de traitement de signal étant configuré pour générer un signal de stimulation, et introduire le signal de stimulation dans une partie cible à l'aide du dispositif fibre optique, afin de réaliser la stimulation de la partie cible ; le dispositif de traitement de signal étant en outre configuré pour recevoir un signal d'activité, et transmettre le signal d'activité au module de traitement de données, le signal d'activité étant un signal obtenu après que la partie cible a été stimulée ; et le module de traitement de données est configuré pour recevoir le signal d'activité émis par le dispositif de traitement de signal, et convertir le signal d'activité en un signal numérique cible.
PCT/CN2021/114434 2021-07-20 2021-08-25 Système de traitement de signal WO2023000433A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110817819.7 2021-07-20
CN202110817819.7A CN115634071A (zh) 2021-07-20 2021-07-20 一种信号处理系统

Publications (1)

Publication Number Publication Date
WO2023000433A1 true WO2023000433A1 (fr) 2023-01-26

Family

ID=84939346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/114434 WO2023000433A1 (fr) 2021-07-20 2021-08-25 Système de traitement de signal

Country Status (2)

Country Link
CN (1) CN115634071A (fr)
WO (1) WO2023000433A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
CN109557092A (zh) * 2018-11-22 2019-04-02 中国人民解放军军事科学院国防科技创新研究院 一种用于增强大脑认知功能的脑神经刺激装置
CN209575533U (zh) * 2018-12-27 2019-11-05 肯维捷斯（武汉）科技有限公司 一种微型植入式光刺激器
CN110478617A (zh) * 2019-08-23 2019-11-22 中国人民解放军军事科学院国防科技创新研究院 一种脑深部电磁耦合刺激与电信号检测的探针
CN111973875A (zh) * 2020-08-14 2020-11-24 北京航空航天大学 一种神经光电组合刺激装置及方法
CN112023271A (zh) * 2020-09-22 2020-12-04 天津工业大学 亚毫米尺寸活体植入式多通道微磁刺激器

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
CN109557092A (zh) * 2018-11-22 2019-04-02 中国人民解放军军事科学院国防科技创新研究院 一种用于增强大脑认知功能的脑神经刺激装置
CN209575533U (zh) * 2018-12-27 2019-11-05 肯维捷斯（武汉）科技有限公司 一种微型植入式光刺激器
CN110478617A (zh) * 2019-08-23 2019-11-22 中国人民解放军军事科学院国防科技创新研究院 一种脑深部电磁耦合刺激与电信号检测的探针
CN111973875A (zh) * 2020-08-14 2020-11-24 北京航空航天大学 一种神经光电组合刺激装置及方法
CN112023271A (zh) * 2020-09-22 2020-12-04 天津工业大学 亚毫米尺寸活体植入式多通道微磁刺激器

Also Published As

Publication number Publication date
CN115634071A (zh) 2023-01-24

Similar Documents

Publication Publication Date Title
CN109557092B (zh) 一种用于增强大脑认知功能的脑神经刺激装置
US8744570B2 (en) Optical stimulation of the brainstem and/or midbrain, including auditory areas
Aravanis et al. An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology
EP2575964B1 (fr) Dispositifs de stimulation nerveuse à infrarouges implantables pour interfaces de nerfs périphériques et crâniens
Deng et al. Optogenetics, the intersection between physics and neuroscience: light stimulation of neurons in physiological conditions
US20130046357A1 (en) Tissue or nerve treatment device and method
Xia et al. Pulsed 808-nm infrared laser stimulation of the auditory nerve in guinea pig cochlea
US20210353967A1 (en) Methods and system for selective and long-term neuromodulation using ultrasound
Throckmorton et al. Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system
Jiang et al. Inhibitory effect of 980-nm laser on neural activity of the rat’s cochlear nucleus
WO2023000433A1 (fr) Système de traitement de signal
US20230100414A1 (en) Providing sensory stimulations via photoacoustic, piezo-based, thermal, and/or electrical effects
Lu et al. Ultrasound retinal stimulation: a mini-review of recent developments
Guo et al. Effects of focused ultrasound in a “clean” mouse model of ultrasonic neuromodulation
CN108937956A (zh) 一种新型TMS-fNIRS脑成像装置
CN112774048A (zh) 一种闭环超声神经调控系统及方法
CN113648542B (zh) 一种颅内神经系统疾病的康复治疗装置及综合治疗装置
WO2023108876A1 (fr) Système de régulation de circuit neuronal et transcrânien ultrasonore holographique et procédé de conception associé
Wang et al. Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser
Jiang et al. Auditory responses to short-wavelength infrared neural stimulation of the rat cochlear nucleus
CN112604191A (zh) 多焦点超声波的生成装置及生成方法
WO2024103445A1 (fr) Système de neuromodulation
Zhou et al. Theoretical simulation of the selective stimulation of axons in different areas of a nerve bundle by multichannel near-infrared lasers
Wells et al. Frontiers in optical stimulation of neural tissues: past, present, and future
US20210023385A1 (en) Method and system for photobiomodulated exosome and stem cell therapy

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21950675

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE