WO2022255981A1 - Procédé de production d'un kit d'essai flexible à base magnétique et timbre cutané - Google Patents

Procédé de production d'un kit d'essai flexible à base magnétique et timbre cutané Download PDF

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Publication number
WO2022255981A1
WO2022255981A1 PCT/TR2022/050513 TR2022050513W WO2022255981A1 WO 2022255981 A1 WO2022255981 A1 WO 2022255981A1 TR 2022050513 W TR2022050513 W TR 2022050513W WO 2022255981 A1 WO2022255981 A1 WO 2022255981A1
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic
alloys
test kit
particles
flexible test
Prior art date
Application number
PCT/TR2022/050513
Other languages
English (en)
Inventor
Ozan AKDOGAN
Sedef OZUNLU
Nilay GUNDUZ AKDOGAN
Original Assignee
Bahcesehir Universitesi
Piri Reis Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2021/009077 external-priority patent/TR2021009077A2/tr
Application filed by Bahcesehir Universitesi, Piri Reis Universitesi filed Critical Bahcesehir Universitesi
Priority to EP22816579.1A priority Critical patent/EP4346575A1/fr
Publication of WO2022255981A1 publication Critical patent/WO2022255981A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/68335—Means for maintaining contact with the body using adhesives including release sheets or liners
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F41/00—Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties
    • H01F41/32—Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for applying conductive, insulating or magnetic material on a magnetic film, specially adapted for a thin magnetic film
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H01F1/08—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder pressed, sintered, or bound together
    • H01F1/083—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder pressed, sintered, or bound together in a bonding agent

Definitions

  • the present invention relates to a method for producing magnetic based flexible test kit and skin patch.
  • Skin patches which are considered as a product of the wearable technology, can be used for different purposes. These purposes include monitoring the changes in the human body, long-term wound protection, drug delivery and determination of the disease. Skin patches can be used as a test kit in the diagnosis of the disease.
  • magnetic based flexible test kits and skin patches are widely produced in said technical field and presented to the users’ demands.
  • studies for improving the production methods of said products still continue. For example, there is a need for novel methods in the technical field that will allow said products to be produced in an affordable and practical way.
  • the main objective of the invention is to develop a method that allows a practical production with a lower cost compared to the current applications, in order to produce magnetic based flexible test kit or skin patch. Thanks to the method of the present invention, it is also possible to shorten the production time.
  • the objective of the invention is to develop a production method that provides advantage of high magnetic flux.
  • the objective of the invention is to obtain a novel method that enables producing magnetic based flexible test kit or skin patch, without requiring the use of machine/equipment.
  • Another advantage of the invention is that the components used in the method of the present invention are easily accessible components.
  • the objective of the invention is to obtain a product that can be used in different areas.
  • Said product produced with the method of the present invention can be used in areas such as determination of the amount of hemoglobin in the blood, determination of cancerous cells in the body, determination of Covid-19 based antibody in the blood, and determination of urea in the blood. Additionally, it is also possible that this product can replace the hemodialysis filter part in the hemodialysis machine, as well as the filters in the factory waste pipes.
  • Figure 1 is a schematic illustration of the process step of preparing particles with strong magnetic properties.
  • Figure 2 is a schematic illustration of the process step of preparing polymer.
  • Figure 3 is a schematic illustration of the process steps of placing the magnetic strips on top of each in order to provide configuration using the North pole and South pole properties, provided that the magnetic strips are not limited to an angle of 0-360°, and pouring the magnetic particles thereon; and pouring polymer, which is prepared with its own procedure, onto the magnetic particles whose configuration is prepared in a desired way.
  • Figure 4 is a schematic illustration of the process steps of boring channels and magnetization.
  • Figure 5 is a schematic illustration of micro/milli/macro fluidic channel.
  • the present invention relates to a method for producing magnetic based flexible test kit and skin patch.
  • the said method comprises the process steps of:
  • At least one particle with magnetic properties selected from a group consisting of NdFeB powder, Fe powder, Nickel (Ni), Cobalt (Co), Sm-Co alloys, Sm-Fe-N alloys, Ferrite magnet powders, alnico group of permanent magnet powders, permalloy (Ni-Fe alloys), Mn-Bi/Ga alloys, Fe-N alloys, Fe-Co alloys, and the combinations thereof is used.
  • At least one polymer selected from a group consisting of PDMS, Hydrogel, SU8, polyethylene, polypropylene, polyvinyl chloride, rubber, nylon, PVB, silicone, polystyrene, neoprene, polyacrylonitrile, and the combinations thereof is used.
  • two magnetic strips are placed on top of each other according to the desired shape without limiting them at a given angle between them.
  • the use of the magnetic strips without being limited to the particles exhibiting magnetic property such as NdFeB powder (5) or Fe flakes, is important in terms of forming a certain pattern and ensuring that the particles are trapped in the polymer with their patterns.
  • the method of the present invention comprises the process step of preparing magnetic particles. Accordingly, particles with strong magnetic properties such as NdFeB flakes (N-F) or Fe flakes are dried and prepared for being trapped in the polymer portion.
  • NdFeB flakes (N-F) or Fe flakes are dried and prepared for being trapped in the polymer portion.
  • the process step of preparing NdFeB flakes (N-F) (Ball- milled NdFeB flakes (N-F)) by drying is given as an example.
  • the particles poured on them have an ordered configuration. Magnetic particles are dispersed into the polymer and thereby providing magnetic flux distribution.
  • the subsequent process step is to prepare the polymer.
  • the polymer is passed through a preparation stage to become skin patch/flexible test kit. This process is performed at room temperature the said process step is given in Figure 2.
  • PDMS polymer
  • its preparation with the curing agent at a ratio of 10:1 can be given as example.
  • Preparation of PDMS according to usage instructions should be at a ratio of 10:1, if it is desired to be prepared by weight, volume, or mole. According to the instructions, the 10:1 ratio is maintained for each preparation method.
  • the prepared polymer is poured on the said structure comprising the ordered configuration which is obtained by pouring the prepared particles on the magnetic strips, and it becomes a stable skin patch/flexible test kit.
  • the process steps of pouring magnetic particles on the strips (having a configuration such as N, S, N, S, ...) placed with a desired angle and adding the prepared polymer thereon are given respectively in Figure 3.
  • Drying the polymer is performed at room temperature within 24 hours by means of the specifically added curing agents.
  • polymer e.g., PDMS/curing agent
  • the magnetic particles (e.g., NdFeB) and polymer (e.g., PDMS/curing agent) are heated at 120 °C to harden on the heater, hardened in a time shorter than 24 hours and become a flexible test kit.
  • a flexible layer having the magnetic particles therein is formed.
  • the layer of the flexible test kit which is placed on the magnet and configured, is given in Figure 5.
  • micro/macro/milli fluidic channels are bored on the flexible test kit.
  • the said fluidic channels enable passage of the sample (liquid) that can be determined through the flexible test kit.
  • the fluidic channel structures, through which the liquid is passed, are also obtained with 3D printer, if desired, and it is ensured that fluidic channel layer is formed by pouring polymer therein.
  • the layer of the flexible test kit which is placed on the magnetic strips and configured ( Figure 5) and for example, channel structure printed with 3D printer are placed on top of each and adhered, thereby the channel is bored.
  • the product (patch/flexible test kit) is magnetized under high magnetic field.
  • electromagnet is used for enabling magnetization.
  • the test kit becomes ready to use when its magnetization is completed.
  • the functionality of the strips used in the said method is achieved both without using configuration machines (spin coater, clean room, lithography, and physical storage devices (magnetron sputtering system)) and in a very short time.
  • the configuration of particles with magnetic properties such as NdFeB powder and Fe powder, is provided by means of the magnetic strips without using the configuration machines. This enables the method of the present invention to be cheap and easily accessible.
  • the substance exhibiting magnetic properties which is desired to be passed through the channel of said magnetic flexible test kit obtained by the method of the present invention and which is desired to be tagged and trapped, is drawn into the injector.
  • Micro/macro/milli fluidic channels comprise input and output parts.
  • the sample, which is desired to be determined is sent into the channel by means of the injector from the input part.
  • the particles (NdFeB powder or Fe powder etc.) with magnetic properties inside the channel attract the structures with magnetic properties inside the sample, which are desired to be determined. By means of this magnetic attraction, the liquid without magnetic properties fills the injector when the liquid inside the channel is withdrawn by another injector from the output.
  • the particles which are desired to be tagged remains in the magnetic flexible test kit.
  • the method of the present invention being cheap and practical will allow to perform several tests such as determination of urea in the urine and determination of cancerous cells, and to diagnose the disease in an easy and quick way.
  • the blood sample which is injected from one side of the produced microfluidic channel (input) is withdrawn by the injector from the other side (output).
  • the injector from the other side (output).
  • the withdrawn blood sample (output) there are no biological structures, which are tagged with magnetic particle or due to their own magnetic characteristics.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Manufacturing & Machinery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un procédé de production d'un kit d'essai flexible à base magnétique et d'un timbre cutané. L'objectif principal de l'invention est de développer un procédé permettant une production pratique avec un coût inférieur à celui des applications actuelles, afin de produire un kit de test flexible à base magnétique ou un timbre cutané. Avec le procédé de la présente invention, il est également possible de raccourcir le temps de production, permettant ainsi une production de masse.
PCT/TR2022/050513 2021-06-02 2022-06-01 Procédé de production d'un kit d'essai flexible à base magnétique et timbre cutané WO2022255981A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22816579.1A EP4346575A1 (fr) 2021-06-02 2022-06-01 Procédé de production d'un kit d'essai flexible à base magnétique et timbre cutané

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021/009077 TR2021009077A2 (tr) 2021-06-02 Manyeti̇k tabanli esnek test ki̇ti̇ ve deri̇ üzeri̇ yama i̇çi̇n bi̇r üreti̇m yöntemi̇
TR2021009077 2021-06-02

Publications (1)

Publication Number Publication Date
WO2022255981A1 true WO2022255981A1 (fr) 2022-12-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (1)

Country Link
WO (1) WO2022255981A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004997A (en) * 1972-01-30 1977-01-25 Seiko Shimada Process of curing a polymerizable composition containing a magnetized powered ferromagnetic material with radioactive rays
WO2006102235A2 (fr) * 2005-03-21 2006-09-28 Nanoset, Llc Dispositif medical imageable par irm
CN103531328A (zh) * 2013-09-27 2014-01-22 浙江德斯泰塑胶有限公司 一种具有磁性的pvb膜片及其制备方法
US20170212021A1 (en) * 2010-09-27 2017-07-27 The General Hospital Corporation Self-Assembled Magnetic Arrays
WO2020144598A2 (fr) * 2019-01-09 2020-07-16 King Abdullah University Of Science And Technology Peau magnétique imperceptible, système de peau magnétique et procédé de fabrication de peau magnétique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004997A (en) * 1972-01-30 1977-01-25 Seiko Shimada Process of curing a polymerizable composition containing a magnetized powered ferromagnetic material with radioactive rays
WO2006102235A2 (fr) * 2005-03-21 2006-09-28 Nanoset, Llc Dispositif medical imageable par irm
US20170212021A1 (en) * 2010-09-27 2017-07-27 The General Hospital Corporation Self-Assembled Magnetic Arrays
CN103531328A (zh) * 2013-09-27 2014-01-22 浙江德斯泰塑胶有限公司 一种具有磁性的pvb膜片及其制备方法
WO2020144598A2 (fr) * 2019-01-09 2020-07-16 King Abdullah University Of Science And Technology Peau magnétique imperceptible, système de peau magnétique et procédé de fabrication de peau magnétique

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