WO2022250634A1 - Dental 3d printer acrylic with boron - Google Patents
Dental 3d printer acrylic with boron Download PDFInfo
- Publication number
- WO2022250634A1 WO2022250634A1 PCT/TR2022/050447 TR2022050447W WO2022250634A1 WO 2022250634 A1 WO2022250634 A1 WO 2022250634A1 TR 2022050447 W TR2022050447 W TR 2022050447W WO 2022250634 A1 WO2022250634 A1 WO 2022250634A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- printer
- acrylic
- boron
- dental
- methacrylate
- Prior art date
Links
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title claims abstract description 17
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title claims description 17
- 229910052796 boron Inorganic materials 0.000 title claims description 17
- 239000000463 material Substances 0.000 claims abstract description 30
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 20
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 19
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 13
- 239000004342 Benzoyl peroxide Substances 0.000 claims abstract description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 claims abstract description 6
- 230000001965 increasing effect Effects 0.000 claims abstract description 6
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 claims abstract description 6
- 229910021540 colemanite Inorganic materials 0.000 claims abstract description 5
- 241000222122 Candida albicans Species 0.000 claims description 4
- 229940095731 candida albicans Drugs 0.000 claims description 3
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 210000004872 soft tissue Anatomy 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 3
- 239000003999 initiator Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000007348 radical reaction Methods 0.000 abstract description 2
- 150000001639 boron compounds Chemical class 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 206010007134 Candida infections Diseases 0.000 description 1
- 208000032767 Device breakage Diseases 0.000 description 1
- 206010035669 Pneumonia aspiration Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 201000009807 aspiration pneumonia Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 238000011960 computer-aided design Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 206010014665 endocarditis Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 201000007119 infective endocarditis Diseases 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/62—Photochemical radical initiators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/0003—Making bridge-work, inlays, implants or the like
- A61C13/0004—Computer-assisted sizing or machining of dental prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
- B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Definitions
- the invention relates to dental 3D printer acrylic comprising boron compounds for enhancing both antimicrobial and resistance properties.
- PMMA Polymethylmethacrylate
- acrylic is the main material used in the manufacturing of full prostheses with the advantages of being inexpensive, easy to repair and providing aesthetics.
- disadvantages of polymerization shrinkage, low mechanical durability and material structure that is susceptible to microbial colonization have been caused by structural problems that have been tried to be corrected for years.
- prostheses are in contact with the oral mucosa for long periods of time and the microorganisms in the biofilm formed on the surface, especially Candida albicans, can cause both local infections called prosthetic stomatitis and systemic infections that may have serious consequences such as aspiration pneumonia, infective endocarditis and pulmonary candidiasis.
- boron compounds have been used to increase both antimicrobial and resistance properties.
- Solid boron and boron compounds have a wide range of applications, from superhard materials and semiconductors to antiseptic, antiviral, antitumor, and antifungal biological compounds.
- Boron is the biological active ingredient in drug manufacturing.
- the use of 3D printer acrylic resin materials including boron presented in the invention has many advantages. One of the most important advantages of this invention is that they show a long-term disinfection effect with their antibacterial activity and their superior mechanical properties have a compatible adhesion with other substances that make up the base and they have increased resistance.
- 3D printer acrylic mainly consists of a mixture of polymethyl-methacrylate (PMMA) and polyethyl-methacrylate (PEMA) and benzoyl peroxide (BPO), which is a radical reaction initiator. However, it is called in this way because the main material is PMMA.
- Commercially available 3D printer acrylics are the forms of liquid material, which consists of different proportions of these materials, stored in light-proof bottles.
- colemanite Ca 2 B 6 0ii.5H 2 0
- Colemanite or other boron compounds have been used in different acrylic resin materials (especially in heat-polymerized conventional methods), but have not been used or evaluated in any of the 3D Printer materials with content differences from conventional materials.
- Boron is an element with antimicrobial properties. It kills microorganisms, prevents the microorganism from forming a plaque on the surface and minimizes oxidative damage. It is a preferred element in the cosmetics sector due to its softness, adhesiveness and durability properties. Thanks to these properties, it helps the resistance and adhesion of acrylic-based resin materials. In Turkey, which is rich in terms of boron mines, boron mines being at the forefront with its advantages has been frequently researched in the field of dentistry in recent years.
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Biophysics (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Ceramic Engineering (AREA)
- Civil Engineering (AREA)
- Composite Materials (AREA)
- Structural Engineering (AREA)
- Dental Preparations (AREA)
Abstract
3D printer acrylic mainly consists of a mixture of polymethyl-methacrylate (PMMA) and polyethyl-methacrylate (PEMA) and benzoyl peroxide (BPO), which is a radical reaction initiator. In this invention, colemanite (Ca2B6O11.5H2O) was added into the acrylic material for 3D printer printing which is liquid-polymerized and in liquid form. Thus, the acrylic used in the 3D printer has both an antimicrobial effect and increased structural resistance properties.
Description
DENTAL 3D PRINTER ACRYLIC WITH BORON
Technical field of the invention
The invention relates to dental 3D printer acrylic comprising boron compounds for enhancing both antimicrobial and resistance properties.
State of art
Complete edentulousness remains a key problem that is frequently encountered all over the world, and full dentures are widely used as a mobile prosthetic solution in the treatment of fully edentulous patients. Polymethylmethacrylate (PMMA), that is, acrylic, is the main material used in the manufacturing of full prostheses with the advantages of being inexpensive, easy to repair and providing aesthetics. In addition, disadvantages of polymerization shrinkage, low mechanical durability and material structure that is susceptible to microbial colonization have been caused by structural problems that have been tried to be corrected for years.
With the introduction of computer-aided design and computer-aided manufacturing (CAD/CAM) technologies in routine dentistry applications, digital developments have been experienced in the field of mobile prostheses and full prostheses can be produced with 3D printers. PMMA’s forms suitable for manufacturing by light polymerization in 3D printers have been presented to the market by various companies. Thanks to the shortening of the manufacturing stage of the prosthesis, full prostheses produced with CAD/CAM technology stand out with the advantages of saving time, making it possible to make prostheses that have better tissue compatibility and therefore less adhesion problems, and offering more advanced mechanical features compared to prostheses produced with traditional methods. Although digital full prostheses have not yet been fully used in daily use, it is foreseen that they will be the prosthesis manufacturing technique preferred in daily routine thanks to these advantages in the future.
Complete prostheses are in contact with the oral mucosa for long periods of time and the microorganisms in the biofilm formed on the surface, especially Candida albicans, can cause both local infections called prosthetic stomatitis and systemic infections that may have
serious consequences such as aspiration pneumonia, infective endocarditis and pulmonary candidiasis. Failure to keep the surface of the prostheses clean due to systemic diseases such as Parkinson’s and rheumatoid arthritis, which are common in geriatric patients using full prostheses, is important in increasing the microbial problems associated with prostheses. Meanwhile, due to the decrease in motor control with old age, patients frequently drop their prostheses and this increases the frequency of encountering prosthetic fractures. Although the mechanical disadvantages related to the technique have been reduced in prostheses produced with CAD/CAM technology, the problems of prosthesis fractures, which are unfortunately encountered due to mechanical problems, continue in PMMA material. The PMMA surface contains micropores that microscopically act as reservoirs for the housing of microorganisms. Researchers have tried to eliminate material-related disadvantages by adding various items to the composition of PMMA material. Studies on traditional PMMA material have often been done, but studies with the addition of material into 3D printer acrylic are not yet very common. In one study, light-polymerized 3D printer acrylic was produced by adding titanium oxide and it was aimed to add advanced properties to the material. In this invention, especially antimicrobial properties were kept in the foreground and it was stated that the addition of material exhibited positive results in obtaining an antimicrobial prosthetic surface.
Technical problems to be solved bv the invention
In this invention, boron compounds have been used to increase both antimicrobial and resistance properties. Solid boron and boron compounds have a wide range of applications, from superhard materials and semiconductors to antiseptic, antiviral, antitumor, and antifungal biological compounds. Boron is the biological active ingredient in drug manufacturing. The use of 3D printer acrylic resin materials including boron presented in the invention has many advantages. One of the most important advantages of this invention is that they show a long-term disinfection effect with their antibacterial activity and their superior mechanical properties have a compatible adhesion with other substances that make up the base and they have increased resistance. Therefore, the inclusion of this material in the structure of 3D printer resins will help to solve the 2 basic technical problems mentioned above, especially the lack of antibacterial activity and insufficient resistance restriction seen in the existing products. Meanwhile, boron-including compounds will be placed in nanotubes with different wall thickness and added to 3D printer acrylic. Thus, the boron compounds will be released in a controlled manner and the antimicrobial effect will be maintained for a long time.
Description of the invention
Long-term disinfection effect was achieved with the 3D printer acrylic resin material including boron presented in the invention and also the base resistance was increased by providing superior mechanical properties to the material.
Detailed description of the invention:
3D printer acrylic mainly consists of a mixture of polymethyl-methacrylate (PMMA) and polyethyl-methacrylate (PEMA) and benzoyl peroxide (BPO), which is a radical reaction initiator. However, it is called in this way because the main material is PMMA. Commercially available 3D printer acrylics are the forms of liquid material, which consists of different proportions of these materials, stored in light-proof bottles. In this invention, colemanite (Ca2B60ii.5H20) was added to the this light-polymerized acrylic material in liquid form. Colemanite or other boron compounds have been used in different acrylic resin materials (especially in heat-polymerized conventional methods), but have not been used or evaluated in any of the 3D Printer materials with content differences from conventional materials.
Boron is an element with antimicrobial properties. It kills microorganisms, prevents the microorganism from forming a plaque on the surface and minimizes oxidative damage. It is a preferred element in the cosmetics sector due to its softness, adhesiveness and durability properties. Thanks to these properties, it helps the resistance and adhesion of acrylic-based resin materials. In Turkey, which is rich in terms of boron mines, boron mines being at the forefront with its advantages has been frequently researched in the field of dentistry in recent years. In a study conducted by adding boron compounds to conventional PMMA, which is generally polymerized with heat, unlike PMMA resins suitable for 3D printer technology, it was reported that the material exhibited improved mechanical properties after the addition of colemanite, but antimicrobial properties were not tested. However, in studies on periodontal pathogens it is reported that boron compounds have bacteriostatic, bactericidal, fungistatic, fungicidal and antiviral effects. Based on this information, it is anticipated that both antimicrobial and mechanical properties of the light-polymerized 3D printer PMMA material including boron can be improved. Because, thanks to the adhesive property of the boron, it is predicted that it will provide a chemical adhesion in polymethyl methacrylate, give additional resistance and durability to the material, and perhaps most importantly, the resin material,
antimicrobial effect of which will continue thanks to the boron, will provide the inactivation of microorganisms.
Thanks to the mechanical durability of the boron to the material, the incidence of frequently encountered prosthetic fractures may decrease and patients may use their prostheses for a longer time. Meanwhile, considering the antimicrobial activity of boron, it is thought that the frequency of fungal infection caused by Candida albicans in soft tissues under prosthesis will decrease. Thus, it is predicted that full prostheses produced with 3D printer acrylic with boron will provide patients with both more durability and antimicrobial properties. This will not only increase the economic life of the materials by increasing the survival time of the prostheses in the mouth, but will also eliminate the external dependence of the 3D printer’s extremely expensive printing materials and will also contribute to the country’s economy with the chance of export.
Claims
1. A dental 3D printer acrylic, characterized in that; it contains boron in addition to polymethyl-methacrylate (PMMA), polyethyl-methacrylate (PEMA), benzoyl peroxide (BPO).
2. Dental 3D printer acrylic according to claim 1 , characterized in that; colemanite (Ca2B60ii.5H20) is added to the polymethyl-methacrylate.
3. Dental 3D printer acrylic according to claim 1 , characterized in that; it is used against fungal infection caused by Candida albicans in soft tissues under prosthesis.
4. Dental 3D printer acrylic according to claim 1 , characterized in that; the fracture resistance of the material is increased structurally thanks to the boron additive as well as its antimicrobial properties.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2021/008596 TR2021008596A2 (en) | 2021-05-25 | Boron Added Dental 3D Printer Acrylic | |
| TR2021008596 | 2021-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022250634A1 true WO2022250634A1 (en) | 2022-12-01 |
Family
ID=84229028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/TR2022/050447 WO2022250634A1 (en) | 2021-05-25 | 2022-05-18 | Dental 3d printer acrylic with boron |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2022250634A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0249650A (en) * | 1988-08-12 | 1990-02-20 | Jishi Toushi Kogyo Kk | Artificial tooth for front tooth part |
| WO2011104704A2 (en) * | 2010-02-24 | 2011-09-01 | Corona Dent. Ltd. | Long lasting dental restorations and methods for preparation thereof |
| WO2020013765A1 (en) * | 2018-07-11 | 2020-01-16 | Structo Pte Ltd | Methods and composition of a dental model for the manufacture of orthodontic appliances without the use of separator |
-
2022
- 2022-05-18 WO PCT/TR2022/050447 patent/WO2022250634A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0249650A (en) * | 1988-08-12 | 1990-02-20 | Jishi Toushi Kogyo Kk | Artificial tooth for front tooth part |
| WO2011104704A2 (en) * | 2010-02-24 | 2011-09-01 | Corona Dent. Ltd. | Long lasting dental restorations and methods for preparation thereof |
| WO2020013765A1 (en) * | 2018-07-11 | 2020-01-16 | Structo Pte Ltd | Methods and composition of a dental model for the manufacture of orthodontic appliances without the use of separator |
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