WO2022226706A1 - Composition for improving sleep quality, pharmaceutical preparation, health supplement, and application - Google Patents

Composition for improving sleep quality, pharmaceutical preparation, health supplement, and application Download PDF

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Publication number
WO2022226706A1
WO2022226706A1 PCT/CN2021/089721 CN2021089721W WO2022226706A1 WO 2022226706 A1 WO2022226706 A1 WO 2022226706A1 CN 2021089721 W CN2021089721 W CN 2021089721W WO 2022226706 A1 WO2022226706 A1 WO 2022226706A1
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parts
sleep quality
improving sleep
composition
pharmaceutical preparation
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PCT/CN2021/089721
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French (fr)
Chinese (zh)
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王佳皓
戚宇潇
新井田洋介
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王佳皓
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Priority to PCT/CN2021/089721 priority Critical patent/WO2022226706A1/en
Publication of WO2022226706A1 publication Critical patent/WO2022226706A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Definitions

  • the present application relates to the field of medical technology, in particular to compositions, pharmaceutical preparations, health foods and applications for improving sleep quality.
  • insomnia mainly manifested as difficulty in falling asleep, difficulty in maintaining sleep, decreased sleep quality, and insomnia.
  • insomnia can not only cause problems such as memory and concentration decline, but also pose a serious threat to the immune system.
  • sedative-hypnotic drugs are usually used to treat insomnia, and the sedative-hypnotic drugs include benzodiazepine receptor agonists, melatonin receptor agonists, and the like.
  • the above sedative and hypnotic drugs can cause dependence and side effects in patients.
  • the embodiments of the present application provide a composition, pharmaceutical preparation, health food and application for improving sleep quality, which can be used to solve a patient's sleep problem without causing dependence and side effects in the patient.
  • the technical solution is as follows:
  • composition for improving sleep quality includes the following components in parts by weight:
  • the composition for improving sleep quality includes the following components in parts by weight: 180-220 parts of ⁇ -aminobutyric acid, 180-220 parts of glycine, 40-60 parts of tryptophan , L-theanine 80-120 parts, lutein 13-18 parts, ⁇ -carotene 0.5-1 part, blueberry extract 10-20 parts.
  • the composition for improving sleep quality includes the following components in parts by weight: 200 parts of ⁇ -aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of ⁇ -carotene, 15 parts of blueberry extract.
  • a pharmaceutical preparation for improving sleep quality comprising: the above-mentioned composition for improving sleep quality.
  • the pharmaceutical preparation for improving sleep quality further includes pharmaceutically acceptable excipients.
  • the pharmaceutical preparation is in the form of granules, pills, tablets, ointments, capsules or oral liquids.
  • a health food for improving sleep quality includes the above-mentioned composition for improving sleep quality.
  • the health food for improving sleep quality is a solid preparation or an oral liquid.
  • the solid preparation is a tablet, capsule, powder or granule.
  • the composition for improving sleep quality provided in the examples of the present application has the functions of improving sleep, promoting sleep, calming the mind, calming the mind, anti-anxiety, calming, relieving stress and fatigue, etc.
  • the composition for improving sleep quality is green, safe and healthy, and is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
  • the composition for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of the patients after waking up.
  • the composition for improving sleep quality provided in the embodiments of the present application can also simultaneously relieve eye symptoms such as eye fatigue and vision deterioration of the user, and improve the problem of overuse of the eyes of the user.
  • an embodiment of the present invention provides a composition for improving sleep quality, and the composition for improving sleep quality includes the following components in parts by weight:
  • the parts by weight of ⁇ -aminobutyric acid include, but are not limited to: 150 parts, 160 parts, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts and the like.
  • parts by weight of glycine include, but are not limited to: 150 parts, 160 parts, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts, and the like.
  • the parts by weight of tryptophan include, but are not limited to: 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, and the like.
  • the parts by weight of L-theanine include but are not limited to: 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts, 130 parts, 140 parts servings, 150 servings, etc.
  • the parts by weight of lutein include, but are not limited to: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts and the like.
  • parts by weight of lutein include, but are not limited to: 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts and the like.
  • the parts by weight of the blueberry extract include but are not limited to: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22, 23, 24, 25, 26, 27, 28, 29, 30, etc.
  • compositions for improving sleep quality provided in the examples of the present application include the following components in parts by weight:
  • compositions for improving sleep quality provided in the embodiments of the present application include the following components by weight:
  • ⁇ -aminobutyric acid For ⁇ -aminobutyric acid, its alias is 4-aminobutyric acid ( ⁇ -aminobutyric acid, GABA for short), which is a naturally occurring active amino acid and an important neurotransmitter. Blood pressure, improve brain blood circulation, sedation and other physiological activities. Studies have found that gamma-aminobutyric acid can effectively relieve life stress, reduce excitement before going to bed, assist sleep, and improve sleep quality.
  • glycine For glycine, glycine (Glycine, Gly for short), also known as glycine, is a non-essential amino acid, and its chemical formula is C 2 H 5 NO 2 . Glycine is the constituent amino acid of the endogenous antioxidant reduced glutathione, and it is often supplemented by exogenous sources when the body is under severe stress. It is also sometimes called a semi-essential amino acid. In the central nervous system, especially in the spine, glycine acts as an inhibitory neurotransmitter, and once glycine receptors are activated, chloride ions enter nerve cells through ion receptors leading to inhibitory postsynaptic potentials. Studies have found that glycine can effectively relieve life stress, reduce excitement before going to bed, assist sleep, and improve sleep quality.
  • tryptophan also known as ⁇ -indolylalanine, chemical formula C 11 H 12 N 2 O 2 , is one of the essential amino acids of the human body. Tryptophan is the precursor of the important neurotransmitter serotonin in the human body. Studies have found that tryptophan can improve depressive symptoms by increasing levels of serotonin in the brain, and can be used as a sedative to regulate mental rhythms and improve sleep.
  • L-theanine is also known as N-ethyl-L-glutamine. Studies have found that L-theanine can significantly promote the release of dopamine in the central brain and improve the physiological activity of dopamine in the brain. Dopamine is a central neurotransmitter that activates brain nerve cells, and its physiological activity is closely related to human emotional state. This allows L-theanine to relieve fatigue, lower blood pressure and improve learning and memory, so that insomnia patients will not feel tired and sleepy after waking up, and improve the energy of insomnia patients.
  • Lutein also known as phytolutein, is a carotenoid that is widely found in vegetables, fruits, flowers and other plants. Its chemical formula contains two ketone rings, which are present in the macular area of the human eye. main pigment. Studies have found that the absorption spectrum of lutein contains near blue-violet light, which can help the retina of the eye to resist ultraviolet rays. For the eyes, lutein is an important antioxidant that plays an important role. Supplementing a large amount of lutein to the human body helps to maintain the durability of vision, improve visual response time, and reduce visual damage. For people with myopia, supplementing lutein can delay the increase of their myopia, and regular use of lutein can effectively prevent the damage of computer radiation to the human body.
  • alpha-carotene is a member of the carotenoid family and is one of the most abundant carotenoids in a healthy diet.
  • the body converts alpha- and beta-carotene into vitamin A needed for healthy skin and bones, good vision and a strong immune system.
  • Alpha-carotene acts as antioxidants, which are enzymes that prevent free radicals from breaking down or oxidizing cells.
  • Alpha-carotene kills free radicals before they damage the body and lead to chronic diseases such as heart disease and cancer.
  • Blueberry extract its components include pectin, anthocyanin, tannin, arbutin, vitamin C and B vitamins, etc. Blueberry extract has the functions of preventing brain nerve aging, strengthening heart, anti-cancer and softening blood vessels, enhancing human immunity, etc. Function.
  • the cyanine II pigment contained in blueberries has the effect of activating the retina, which can strengthen vision and prevent eye fatigue.
  • the mass percentage of proanthocyanidins can be 10%-40%, for example, 15%, 20%, 25%, 30%, 35%, and the like.
  • the composition for improving sleep quality provided in the examples of the present application has the functions of improving sleep, promoting sleep, calming the mind, calming the mind, anti-anxiety, sedation, relieving stress and fatigue through the synergistic compounding effect of the above components in parts by weight. and so on.
  • the composition for improving sleep quality is green, safe and healthy, and is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
  • the composition for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of the patients after waking up.
  • the composition for improving sleep quality provided by the embodiments of the present application can also relieve eye symptoms such as eye fatigue and vision deterioration of the user, and improve the problem of overuse of the eyes of the user.
  • composition for improving sleep quality provided in the examples of the present application, it can be prepared by the following method:
  • each component in the composition 150-250 parts of ⁇ -aminobutyric acid, 150-250 parts of glycine, 30-100 parts of tryptophan, 50-150 parts of L -Theanine, 10 to 20 parts of lutein, 0.5 to 1.5 parts of alpha-carotene, and 10 to 30 parts of blueberry extract are mixed uniformly to obtain the composition for improving sleep quality.
  • the above-mentioned preparation process can be carried out in a container with a stirring device, so as to ensure that each component is fully mixed evenly.
  • composition for improving sleep quality provided in the embodiments of the present application can be directly taken by the user during application, for example, the user can directly take the composition in powder form.
  • the embodiments of the present application also provide a pharmaceutical preparation for improving sleep quality, wherein the pharmaceutical preparation comprises: the above-mentioned composition for improving sleep quality.
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • the pharmaceutical preparations for improving sleep quality provided in the examples of the present application, by using the above composition, the various components in each weight portion in the composition are synergistically compounded, and have the functions of improving sleep, promoting sleep, calming the mind, anti-anxiety, and sedation. , relieve stress and fatigue.
  • the pharmaceutical preparation is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
  • the pharmaceutical preparation for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients, and improve the feeling of exhaustion after waking up.
  • the pharmaceutical preparations for improving sleep quality provided in the embodiments of the present application can also relieve the user's eye symptoms such as eye fatigue and vision deterioration, and improve the user's overuse problem.
  • the pharmaceutical preparation for improving sleep quality provided in the embodiments of the present application further includes: pharmaceutically acceptable excipients.
  • the pharmaceutically acceptable excipients include, but are not limited to, at least one of sorbitol, maltodextrin, isomalt oligosaccharide, magnesium stearate, lactose, xylitol, fructose and sucrose.
  • the pharmaceutical preparation for improving sleep quality provided in the embodiments of the present application is in the form of granules, pills, tablets, ointments, capsules or oral liquids.
  • the pharmaceutical preparations are prepared into various common dosage forms for the convenience of patients.
  • the embodiments of the present application also provide a health food for improving sleep quality, the health food comprising the above-mentioned composition for improving sleep quality.
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • the health food for improving sleep quality provided in the examples of the present application, by using the above composition, the various components in each weight portion in the composition are synergistically compounded, and have the functions of improving sleep, promoting sleep, calming the mind, anti-anxiety, and sedation. , relieve stress and fatigue.
  • the health food is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
  • the health food for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of patients after waking up.
  • the health food for improving sleep quality provided by the embodiments of the present application can also relieve the user's eye symptoms such as eye fatigue and vision deterioration, and improve the user's overuse problem.
  • the health food for improving sleep quality can be a solid preparation or an oral liquid.
  • solid preparations are tablets, capsules, powders or granules and the like.
  • the above-mentioned pharmaceutical preparations or health food for improving sleep quality in the examples of the present application can be prepared by using conventional preparation techniques in the art, which are not described in more detail in the examples of the present application.
  • the embodiments of the present application also provide the application of any of the above-mentioned compositions for improving sleep quality in preparing sleep aid medicine or sleep aid food.
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • composition for improving sleep quality includes the following components in parts by weight:
  • the present embodiment 1 provides a composition for improving sleep quality, which comprises the following components by weight:
  • the present embodiment 2 provides a composition for improving sleep quality, which comprises the following components by weight:
  • ⁇ -aminobutyric acid 180 parts of ⁇ -aminobutyric acid, 220 parts of glycine, 60 parts of tryptophan, 80 parts of L-theanine, 15 parts of lutein, 0.65 parts of ⁇ -carotene, and 15 parts of blueberry extract.
  • the present embodiment 3 provides a composition for improving sleep quality, which comprises the following components by weight:
  • the present embodiment 4 provides a composition for improving sleep quality, which comprises the following components by weight:
  • the present embodiment 5 provides a composition for improving sleep quality, which comprises the following components in parts by weight:
  • ⁇ -aminobutyric acid 250 parts of ⁇ -aminobutyric acid, 200 parts of glycine, 55 parts of tryptophan, 110 parts of L-theanine, 18 parts of lutein, 0.8 parts of ⁇ -carotene, and 18 parts of blueberry extract.
  • This Test Example 1 used the compositions for improving sleep quality provided in Examples 1 to 5, respectively, and let 20 insomniacs take them for 7 consecutive days, drinking once a day in the morning, noon and night, and the dosage was the same each time. And record the sleep improvement effect of insomnia patients after 7 days.
  • the insomnia patients who took the composition for improving sleep quality provided in Example 1 had more prominent effects of assisting sleep and improving insomnia symptoms.
  • test method for improving sleep function in the "Technical Specification for Health Food Inspection and Evaluation" of the Ministry of Health of the People's Republic of China, specifically: direct sleep experiment, prolonged pentobarbital sodium sleep Time test, pentobarbital sodium subthreshold dose hypnosis test; barbital sodium sleep latency test.
  • compositions provided in Example 1-Example 5 can significantly prolong the sleep time induced by sodium pentobarbital in mice, shorten the sleep latency of sodium pentobarbital in mice, and increase the subthreshold dose hypnosis test of sodium pentobarbital Number of sleeping animals in mice. Tests show that the compositions provided in Examples 1-5 have the effect of improving sleep function.
  • mice taking the composition for improving sleep quality provided in Example 1 had a more prominent effect of assisting sleep.

Abstract

A composition for improving sleep quality, a pharmaceutical preparation, a health supplement and an application, which belong to the technical field of medicine. The composition for improving sleep quality comprises the following components in parts by weight: 150-250 parts γ-aminobutyric acid, 150-250 parts glycine, 30-100 parts tryptophan, 50-150 parts L-theanine, 10-20 parts lutein, 0.5-1.5 parts α-carotene, and 10-30 parts blueberry extract. The composition has the effects of improving sleep, promoting sleep, relieving uneasiness and calming the nerves, is anti-anxiety, sedating, and pressure and fatigue-relieving, etc. The composition can also effectively ameliorate the insomnia symptoms of insomnia patients, alleviate fatigue in patients after waking, and alleviate eye symptoms of users, such as eye fatigue and vision degradation.

Description

改善睡眠质量的组合物、药物制剂、保健食品及应用Composition, pharmaceutical preparation, health food and application for improving sleep quality 技术领域technical field
本申请涉及医药技术领域，特别涉及改善睡眠质量的组合物、药物制剂、保健食品及应用。The present application relates to the field of medical technology, in particular to compositions, pharmaceutical preparations, health foods and applications for improving sleep quality.
背景技术Background technique
随着社会生活的节奏加快和压力增加，越来越多的人面临睡眠障碍的问题，主要表现为入睡困难、睡眠维持困难、睡眠质量下降、失眠等。特别是对于失眠患者，长时间失眠不仅会引起记忆力和注意力下降等问题，还会对免疫系统造成严重威胁。With the accelerated pace of social life and the increase of pressure, more and more people are facing the problem of sleep disorders, mainly manifested as difficulty in falling asleep, difficulty in maintaining sleep, decreased sleep quality, and insomnia. Especially for patients with insomnia, prolonged insomnia can not only cause problems such as memory and concentration decline, but also pose a serious threat to the immune system.
相关技术中，通常使用镇静催眠类药物来治疗失眠，镇静催眠类药物包括苯二氮卓类受体激动剂、褪黑素受体激动剂等。In the related art, sedative-hypnotic drugs are usually used to treat insomnia, and the sedative-hypnotic drugs include benzodiazepine receptor agonists, melatonin receptor agonists, and the like.
然而，在实现本发明的过程中，发明人发现相关技术至少存在以下技术问题：However, in the process of realizing the present invention, the inventor found that the related art at least has the following technical problems:
上述镇静催眠类药物会使患者产生依赖性和副作用。The above sedative and hypnotic drugs can cause dependence and side effects in patients.
申请内容Application content
本申请实施例提供了一种改善睡眠质量的组合物、药物制剂、保健食品及应用，可以用于解决患者的睡眠问题，且不会使患者产生依赖性和副作用问题。所述技术方案如下：The embodiments of the present application provide a composition, pharmaceutical preparation, health food and application for improving sleep quality, which can be used to solve a patient's sleep problem without causing dependence and side effects in the patient. The technical solution is as follows:
一个方面，提供了一种改善睡眠质量的组合物，所述改善睡眠质量的组合物包括以下重量份的组分：In one aspect, a composition for improving sleep quality is provided, and the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
在一些可能的实现方式中，所述改善睡眠质量的组合物包括以下重量份的组分：γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取 物10份-20份。In some possible implementations, the composition for improving sleep quality includes the following components in parts by weight: 180-220 parts of γ-aminobutyric acid, 180-220 parts of glycine, 40-60 parts of tryptophan , L-theanine 80-120 parts, lutein 13-18 parts, α-carotene 0.5-1 part, blueberry extract 10-20 parts.
在一些可能的实现方式中，所述改善睡眠质量的组合物包括以下重量份的组分：γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。In some possible implementations, the composition for improving sleep quality includes the following components in parts by weight: 200 parts of γ-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of α-carotene, 15 parts of blueberry extract.
另一个方面，提供了一种改善睡眠质量的药物制剂，所述药物制剂包括：上述所述的改善睡眠质量的组合物。In another aspect, a pharmaceutical preparation for improving sleep quality is provided, the pharmaceutical preparation comprising: the above-mentioned composition for improving sleep quality.
在一些可能的实现方式中，所述改善睡眠质量的药物制剂还包括药学上可接受的辅料。In some possible implementations, the pharmaceutical preparation for improving sleep quality further includes pharmaceutically acceptable excipients.
在一些可能的实现方式中，所述药物制剂的剂型为颗粒剂、丸剂、片剂、膏剂、胶囊剂或口服液。In some possible implementations, the pharmaceutical preparation is in the form of granules, pills, tablets, ointments, capsules or oral liquids.
再一个方面，提供了一种改善睡眠质量的保健食品，所述保健食品包括上述所述的改善睡眠质量的组合物。In yet another aspect, a health food for improving sleep quality is provided, and the health food includes the above-mentioned composition for improving sleep quality.
在一些可能的实现方式中，所述改善睡眠质量的保健食品为固体制剂或者口服液。In some possible implementations, the health food for improving sleep quality is a solid preparation or an oral liquid.
在一些可能的实现方式中，所述固体制剂为片剂、胶囊剂、粉剂或者颗粒剂。In some possible implementations, the solid preparation is a tablet, capsule, powder or granule.
再一个方面，提供了上述所述的改善睡眠质量的组合物制备助眠药物或者助眠食品中的应用。In yet another aspect, there is provided the application of the above-mentioned composition for improving sleep quality in preparing sleep aid medicine or sleep aid food.
本申请实施例提供的技术方案带来的有益效果至少包括：The beneficial effects brought by the technical solutions provided in the embodiments of the present application include at least:
本申请实施例提供的改善睡眠质量的组合物，通过上述重量份的各组分的协同复配作用，具有改善睡眠、促进睡眠、安神宁心、抗焦虑、镇静、缓解压力和疲劳等作用。该改善睡眠质量的组合物绿色、安全、健康，不仅适合患有失眠或其他睡眠障碍的人群服用，还适合工作压力大、易疲劳、易紧张焦虑等人群服用。The composition for improving sleep quality provided in the examples of the present application has the functions of improving sleep, promoting sleep, calming the mind, calming the mind, anti-anxiety, calming, relieving stress and fatigue, etc. The composition for improving sleep quality is green, safe and healthy, and is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
特别地，对于失眠患者，该改善睡眠质量的组合物能够有效改善失眠患者的失眠症状，改善患者睡醒后的疲惫感。并且，本申请实施例提供的改善睡眠质量的组合物，还可以同时缓解服用者的眼部疲劳、视力退化等眼部症状，改 善服用者的用眼过度问题。In particular, for insomnia patients, the composition for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of the patients after waking up. In addition, the composition for improving sleep quality provided in the embodiments of the present application can also simultaneously relieve eye symptoms such as eye fatigue and vision deterioration of the user, and improve the problem of overuse of the eyes of the user.
具体实施方式Detailed ways
为使本申请的目的、技术方案和优点更加清楚，下面将对本申请实施方式作进一步地详细描述。In order to make the objectives, technical solutions and advantages of the present application clearer, the embodiments of the present application will be described in further detail below.
一个方面，本发明实施例提供了一种改善睡眠质量的组合物，该改善睡眠质量的组合物包括以下重量份的组分：In one aspect, an embodiment of the present invention provides a composition for improving sleep quality, and the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
示例地，γ-氨基丁酸的重量份包括但不限于：150份、160份、170份、180份、190份、200份、210份、220份、230份、240份、250份等。Illustratively, the parts by weight of γ-aminobutyric acid include, but are not limited to: 150 parts, 160 parts, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts and the like.
示例地，甘氨酸的重量份包括但不限于：150份、160份、170份、180份、190份、200份、210份、220份、230份、240份、250份等。Illustratively, parts by weight of glycine include, but are not limited to: 150 parts, 160 parts, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts, and the like.
示例地，色氨酸的重量份包括但不限于：30份、40份、50份、60份、70份、80份、90份、100份等。Illustratively, the parts by weight of tryptophan include, but are not limited to: 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, and the like.
示例地，L-茶氨酸的重量份包括但不限于：30份、40份、50份、60份、70份、80份、90份、100份、110份、120份、130份、140份、150份等。Illustratively, the parts by weight of L-theanine include but are not limited to: 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts, 100 parts, 110 parts, 120 parts, 130 parts, 140 parts servings, 150 servings, etc.
示例地，叶黄素的重量份包括但不限于：10份、11份、12份、13份、14份、15份、16份、17份、18份、19份、20份等。Illustratively, the parts by weight of lutein include, but are not limited to: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts and the like.
示例地，叶黄素的重量份包括但不限于：0.5份、0.6份、0.7份、0.8份、0.9份、1份、1.1份、1.2份、1.3份、1.4份、1.5份等。Illustratively, parts by weight of lutein include, but are not limited to: 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts and the like.
示例地，蓝莓提取物的重量份包括但不限于：10份、11份、12份、13份、14份、15份、16份、17份、18份、19份、20份、21份、22份、23份、24份、25份、26份、27份、28份、29份、30份等。Exemplarily, the parts by weight of the blueberry extract include but are not limited to: 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22, 23, 24, 25, 26, 27, 28, 29, 30, etc.
在一些可能的实现方式中，本申请实施例提供的改善睡眠质量的组合物包括以下重量份的组分：In some possible implementations, the compositions for improving sleep quality provided in the examples of the present application include the following components in parts by weight:
γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取物10份-20份。Gamma-aminobutyric acid 180-220 parts, glycine 180-220 parts, tryptophan 40-60 parts, L-theanine 80-120 parts, lutein 13-18 parts, α-carrot 0.5-1 serving of vegetarian, 10-20 servings of blueberry extract.
示例地，本申请实施例提供的改善睡眠质量的组合物包括以下重量份的组 分：Illustratively, the compositions for improving sleep quality provided in the embodiments of the present application include the following components by weight:
γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
对于γ-氨基丁酸，其别名为4-氨基丁酸(γ-aminobutyric acid，简称GABA)，是一种天然存在的活性氨基酸，是重要的神经递质，它参与多种代谢活动，具有降血压、改善脑部血液循环、镇静等生理活性。研究发现，γ-氨基丁酸可以有效缓解生活压力，降低睡前兴奋度，辅助睡眠，提高睡眠质量。For γ-aminobutyric acid, its alias is 4-aminobutyric acid (γ-aminobutyric acid, GABA for short), which is a naturally occurring active amino acid and an important neurotransmitter. Blood pressure, improve brain blood circulation, sedation and other physiological activities. Studies have found that gamma-aminobutyric acid can effectively relieve life stress, reduce excitement before going to bed, assist sleep, and improve sleep quality.
对于甘氨酸，甘氨酸(Glycine，简称Gly)，又名氨基乙酸，是一种非必需氨基酸，其化学式为C 2H 5NO 2。甘氨酸是内源性抗氧化剂还原型谷胱甘肽的组成氨基酸，机体发生严重应激时常外源补充，有时也称为半必需氨基酸。在中枢神经系统，尤其是在脊椎里，甘氨酸作为抑制性神经递质，一旦甘氨酸接受器被激活，氯离子通过离子接受器进入神经细胞导致抑制性突触后电位。研究发现，甘氨酸可以有效缓解生活压力，降低睡前兴奋度，辅助睡眠，提高睡眠质量。 For glycine, glycine (Glycine, Gly for short), also known as glycine, is a non-essential amino acid, and its chemical formula is C 2 H 5 NO 2 . Glycine is the constituent amino acid of the endogenous antioxidant reduced glutathione, and it is often supplemented by exogenous sources when the body is under severe stress. It is also sometimes called a semi-essential amino acid. In the central nervous system, especially in the spine, glycine acts as an inhibitory neurotransmitter, and once glycine receptors are activated, chloride ions enter nerve cells through ion receptors leading to inhibitory postsynaptic potentials. Studies have found that glycine can effectively relieve life stress, reduce excitement before going to bed, assist sleep, and improve sleep quality.
对于色氨酸，色氨酸(Tryptophan)又称β-吲哚基丙氨酸，化学式C 11H 12N 2O 2，是人体的必须氨基酸之一。色氨酸是人体中重要的神经递质5-羟色胺的前体。研究发现，色氨酸能通过增加脑中血清素的水平而改善抑郁症状，并且可作为安神药，以调节精神节律，改善睡眠。 For tryptophan, tryptophan (Tryptophan), also known as β-indolylalanine, chemical formula C 11 H 12 N 2 O 2 , is one of the essential amino acids of the human body. Tryptophan is the precursor of the important neurotransmitter serotonin in the human body. Studies have found that tryptophan can improve depressive symptoms by increasing levels of serotonin in the brain, and can be used as a sedative to regulate mental rhythms and improve sleep.
对于L-茶氨酸，L-茶氨酸又称N-乙基-L-谷氨酰胺，研究发现，L-茶氨酸可以明显促进脑中枢多巴胺释放，提高脑内多巴胺生理活性。多巴胺是一种活化脑神经细胞的中枢神经递质，其生理活性与人的感情状态密切相关。这就使得L-茶氨酸可以解消疲劳、降低血压和提高学习记忆能力，使失眠患者在睡醒后不会感觉到疲惫和困倦，提升失眠患者的精力。For L-theanine, L-theanine is also known as N-ethyl-L-glutamine. Studies have found that L-theanine can significantly promote the release of dopamine in the central brain and improve the physiological activity of dopamine in the brain. Dopamine is a central neurotransmitter that activates brain nerve cells, and its physiological activity is closely related to human emotional state. This allows L-theanine to relieve fatigue, lower blood pressure and improve learning and memory, so that insomnia patients will not feel tired and sleepy after waking up, and improve the energy of insomnia patients.
对于叶黄素，叶黄素又称植物黄体素，是一种类胡萝卜素，在蔬菜、水果、花卉等植物中广泛存在，其化学式中含有两个酮环，是存在于人眼视网膜黄斑区的主要色素。研究发现，叶黄素吸收光谱含有近蓝紫光，能够帮助眼睛的视网膜抵御紫外线。对于眼睛来说，叶黄素是一种重要的发挥作用的抗氧化剂，向人体补充大量叶黄素，有助于维护视力持久度，提高视觉反应时间，减少视觉伤害。对于近视者来说，补充叶黄素可以延缓其近视度数的增加，并且，经常使用叶黄素能有效防止计算机辐射对人体的损害。Lutein, also known as phytolutein, is a carotenoid that is widely found in vegetables, fruits, flowers and other plants. Its chemical formula contains two ketone rings, which are present in the macular area of the human eye. main pigment. Studies have found that the absorption spectrum of lutein contains near blue-violet light, which can help the retina of the eye to resist ultraviolet rays. For the eyes, lutein is an important antioxidant that plays an important role. Supplementing a large amount of lutein to the human body helps to maintain the durability of vision, improve visual response time, and reduce visual damage. For people with myopia, supplementing lutein can delay the increase of their myopia, and regular use of lutein can effectively prevent the damage of computer radiation to the human body.
对于α-胡萝卜素，α-胡萝卜素(Alpha-carotene)是类胡萝卜素家族成员之 一，并且是健康饮食中含量最丰富的类胡萝卜素之一。人体能将α-和β-胡萝卜素转变成维持健康皮肤和骨头，良好视力和强大免疫系统需要的维生素A。α-胡萝卜素能够作为抗氧化剂，抗氧化剂是阻止自由基分解或氧化细胞的酶。α-胡萝卜素能在自由基损害身体，并导致心脏病和癌症等慢性疾病之前将它们消灭。As for alpha-carotene, alpha-carotene is a member of the carotenoid family and is one of the most abundant carotenoids in a healthy diet. The body converts alpha- and beta-carotene into vitamin A needed for healthy skin and bones, good vision and a strong immune system. Alpha-carotene acts as antioxidants, which are enzymes that prevent free radicals from breaking down or oxidizing cells. Alpha-carotene kills free radicals before they damage the body and lead to chronic diseases such as heart disease and cancer.
蓝莓提取物，其成分包括果胶、花色苷、单宁、熊果苷、维生素C和B族维生素等，蓝莓提取物具有防止脑神经老化、强心、抗癌软化血管、增强人机体免疫等功能。蓝莓中含的花青贰色素，具有活化视网膜功效，可以强化视力，防止眼球疲劳。Blueberry extract, its components include pectin, anthocyanin, tannin, arbutin, vitamin C and B vitamins, etc. Blueberry extract has the functions of preventing brain nerve aging, strengthening heart, anti-cancer and softening blood vessels, enhancing human immunity, etc. Function. The cyanine II pigment contained in blueberries has the effect of activating the retina, which can strengthen vision and prevent eye fatigue.
本申请实施例中，所使用的蓝莓提取物中，原花青素的质量百分含量可以为10％-40％，例如为15％、20％、25％、30％、35％等。In the examples of the present application, in the blueberry extract used, the mass percentage of proanthocyanidins can be 10%-40%, for example, 15%, 20%, 25%, 30%, 35%, and the like.
综上，本申请实施例提供的改善睡眠质量的组合物，通过上述重量份的各组分的协同复配作用，具有改善睡眠、促进睡眠、安神宁心、抗焦虑、镇静、缓解压力和疲劳等作用。该改善睡眠质量的组合物绿色、安全、健康，不仅适合患有失眠或其他睡眠障碍的人群服用，还适合工作压力大、易疲劳、易紧张焦虑等人群服用。To sum up, the composition for improving sleep quality provided in the examples of the present application has the functions of improving sleep, promoting sleep, calming the mind, calming the mind, anti-anxiety, sedation, relieving stress and fatigue through the synergistic compounding effect of the above components in parts by weight. and so on. The composition for improving sleep quality is green, safe and healthy, and is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
特别地，对于失眠患者，该改善睡眠质量的组合物能够有效改善失眠患者的失眠症状，改善患者睡醒后的疲惫感。并且，本申请实施例提供的改善睡眠质量的组合物，还可以同时缓解服用者的眼部疲劳、视力退化等眼部症状，改善服用者的用眼过度问题。In particular, for insomnia patients, the composition for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of the patients after waking up. In addition, the composition for improving sleep quality provided by the embodiments of the present application can also relieve eye symptoms such as eye fatigue and vision deterioration of the user, and improve the problem of overuse of the eyes of the user.
对于本申请实施例提供的上述改善睡眠质量的组合物，其可以通过如下方法制备得到：For the above-mentioned composition for improving sleep quality provided in the examples of the present application, it can be prepared by the following method:
按照该组合物中各组分的重量比，将150份-250份的γ-氨基丁酸、150份-250份的甘氨酸、30份-100份的色氨酸、50份-150份的L-茶氨酸、10份-20份的叶黄素、0.5份-1.5份的α-胡萝卜素、10份-30份的蓝莓提取物混合均匀，得到该改善睡眠质量的组合物。According to the weight ratio of each component in the composition, 150-250 parts of γ-aminobutyric acid, 150-250 parts of glycine, 30-100 parts of tryptophan, 50-150 parts of L -Theanine, 10 to 20 parts of lutein, 0.5 to 1.5 parts of alpha-carotene, and 10 to 30 parts of blueberry extract are mixed uniformly to obtain the composition for improving sleep quality.
其中，上述制备过程可以在具有搅拌装置的容器中进行，以确保各个组分充分混合均匀。Wherein, the above-mentioned preparation process can be carried out in a container with a stirring device, so as to ensure that each component is fully mixed evenly.
本申请实施例提供的上述改善睡眠质量的组合物，在应用时，可以被服用者直接服用，例如，服用者直接服用粉末形式的组合物。The above-mentioned composition for improving sleep quality provided in the embodiments of the present application can be directly taken by the user during application, for example, the user can directly take the composition in powder form.
另一方面，本申请实施例还提供了一种改善睡眠质量的药物制剂，其中，药物制剂包括：上述所述的改善睡眠质量的组合物。On the other hand, the embodiments of the present application also provide a pharmaceutical preparation for improving sleep quality, wherein the pharmaceutical preparation comprises: the above-mentioned composition for improving sleep quality.
示例地，该改善睡眠质量的组合物包括以下重量份的组分：Illustratively, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
进一步示例，该改善睡眠质量的组合物包括以下重量份的组分：As a further example, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取物10份-20份。Gamma-aminobutyric acid 180-220 parts, glycine 180-220 parts, tryptophan 40-60 parts, L-theanine 80-120 parts, lutein 13-18 parts, α-carrot 0.5-1 serving of vegetarian, 10-20 servings of blueberry extract.
作为一种典型的示例，本申请实施例提供的改善睡眠质量的组合物包括以下重量份的组分：As a typical example, the composition for improving sleep quality provided in the embodiments of the present application includes the following components in parts by weight:
γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
本申请实施例提供的改善睡眠质量的药物制剂，通过使用了上述组合物，组合物中各重量份的多种组分协同复配，具有改善睡眠、促进睡眠、安神宁心、抗焦虑、镇静、缓解压力和疲劳等作用。该药物制剂不仅适合患有失眠或其他睡眠障碍的人群服用，还适合工作压力大、易疲劳、易紧张焦虑等人群服用。The pharmaceutical preparations for improving sleep quality provided in the examples of the present application, by using the above composition, the various components in each weight portion in the composition are synergistically compounded, and have the functions of improving sleep, promoting sleep, calming the mind, anti-anxiety, and sedation. , relieve stress and fatigue. The pharmaceutical preparation is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
特别地，对于失眠患者，该改善睡眠质量的药物制剂能够有效改善失眠患者的失眠症状，改善患者睡醒后的疲惫感。并且，本申请实施例提供的改善睡眠质量的药物制剂，还可以同时缓解服用者的眼部疲劳、视力退化等眼部症状，改善服用者的用眼过度问题。In particular, for insomnia patients, the pharmaceutical preparation for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients, and improve the feeling of exhaustion after waking up. In addition, the pharmaceutical preparations for improving sleep quality provided in the embodiments of the present application can also relieve the user's eye symptoms such as eye fatigue and vision deterioration, and improve the user's overuse problem.
在一些可能的实现方式中，本申请实施例提供的改善睡眠质量的药物制剂还包括：药学上可接受的辅料。In some possible implementations, the pharmaceutical preparation for improving sleep quality provided in the embodiments of the present application further includes: pharmaceutically acceptable excipients.
举例来说，该药学上可接受的辅料包括但不限于：山梨糖醇、麦芽糊精、低聚异麦芽糖、硬脂酸镁、乳糖、木糖醇、果糖和蔗糖中至少一种。For example, the pharmaceutically acceptable excipients include, but are not limited to, at least one of sorbitol, maltodextrin, isomalt oligosaccharide, magnesium stearate, lactose, xylitol, fructose and sucrose.
在一些可能的实现方式中，本申请实施例提供的改善睡眠质量的药物制剂的剂型为颗粒剂、丸剂、片剂、膏剂、胶囊剂或口服液。将药物制剂制备成常见的各种剂型，以方便患者服用。In some possible implementations, the pharmaceutical preparation for improving sleep quality provided in the embodiments of the present application is in the form of granules, pills, tablets, ointments, capsules or oral liquids. The pharmaceutical preparations are prepared into various common dosage forms for the convenience of patients.
再一方面，本申请实施例还提供了一种改善睡眠质量的保健食品，该保健食品包括上述所述的改善睡眠质量的组合物。In another aspect, the embodiments of the present application also provide a health food for improving sleep quality, the health food comprising the above-mentioned composition for improving sleep quality.
示例地，该改善睡眠质量的组合物包括以下重量份的组分：Illustratively, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
进一步示例，该改善睡眠质量的组合物包括以下重量份的组分：As a further example, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取物10份-20份。Gamma-aminobutyric acid 180-220 parts, glycine 180-220 parts, tryptophan 40-60 parts, L-theanine 80-120 parts, lutein 13-18 parts, α-carrot 0.5-1 serving of vegetarian, 10-20 servings of blueberry extract.
作为一种典型的示例，本申请实施例提供的改善睡眠质量的组合物包括以下重量份的组分：As a typical example, the composition for improving sleep quality provided in the embodiments of the present application includes the following components in parts by weight:
γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
本申请实施例提供的改善睡眠质量的保健食品，通过使用了上述组合物，组合物中各重量份的多种组分协同复配，具有改善睡眠、促进睡眠、安神宁心、抗焦虑、镇静、缓解压力和疲劳等作用。该保健食品不仅适合患有失眠或其他睡眠障碍的人群服用，还适合工作压力大、易疲劳、易紧张焦虑等人群服用。The health food for improving sleep quality provided in the examples of the present application, by using the above composition, the various components in each weight portion in the composition are synergistically compounded, and have the functions of improving sleep, promoting sleep, calming the mind, anti-anxiety, and sedation. , relieve stress and fatigue. The health food is not only suitable for people with insomnia or other sleep disorders to take, but also suitable for people with high work pressure, easy fatigue, easy tension and anxiety, and the like.
特别地，对于失眠患者，该改善睡眠质量的保健食品能够有效改善失眠患者的失眠症状，改善患者睡醒后的疲惫感。并且，本申请实施例提供的改善睡眠质量的保健食品，还可以同时缓解服用者的眼部疲劳、视力退化等眼部症状，改善服用者的用眼过度问题。In particular, for insomnia patients, the health food for improving sleep quality can effectively improve the insomnia symptoms of insomnia patients and improve the tiredness of patients after waking up. In addition, the health food for improving sleep quality provided by the embodiments of the present application can also relieve the user's eye symptoms such as eye fatigue and vision deterioration, and improve the user's overuse problem.
在一些可能的实现方式中，该改善睡眠质量的保健食品可以为固体制剂或者口服液。In some possible implementations, the health food for improving sleep quality can be a solid preparation or an oral liquid.
示例地，固体制剂为片剂、胶囊剂、粉剂或者颗粒剂等。Illustratively, solid preparations are tablets, capsules, powders or granules and the like.
其中，本申请实施例上述所述的改善睡眠质量的药物制剂或者保健食品均可以采用本领域常规的制剂技术进行制备，本申请实施例在此对其不作更具体的描述。Wherein, the above-mentioned pharmaceutical preparations or health food for improving sleep quality in the examples of the present application can be prepared by using conventional preparation techniques in the art, which are not described in more detail in the examples of the present application.
再一方面，本申请实施例还提供了上述的任一种改善睡眠质量的组合物制备助眠药物或者助眠食品中的应用。In another aspect, the embodiments of the present application also provide the application of any of the above-mentioned compositions for improving sleep quality in preparing sleep aid medicine or sleep aid food.
示例地，该改善睡眠质量的组合物包括以下重量份的组分：Illustratively, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
进一步示例，该改善睡眠质量的组合物包括以下重量份的组分：As a further example, the composition for improving sleep quality includes the following components in parts by weight:
γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取物10份-20份。Gamma-aminobutyric acid 180-220 parts, glycine 180-220 parts, tryptophan 40-60 parts, L-theanine 80-120 parts, lutein 13-18 parts, α-carrot 0.5-1 serving of vegetarian, 10-20 servings of blueberry extract.
作为一种典型的示例，本申请实施例提供的改善睡眠质量的组合物包括以下重量份的组分：As a typical example, the composition for improving sleep quality provided in the embodiments of the present application includes the following components in parts by weight:
γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
下面将以更具体的实施例进一步详细地描述本申请的实施方式。以下实施例中未注明具体技术或条件者，按照本领域内的文献所描述的技术或条件或者按照产品说明书进行。所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规产品。The embodiments of the present application will be described in further detail below with more specific examples. If no specific technique or condition is indicated in the following examples, the technique or condition described in the literature in this field or the product specification is used. The reagents or instruments used without the manufacturer's indication are conventional products that can be obtained from the market.
实施例1Example 1
本实施例1提供了一种改善睡眠质量的组合物，其包括以下重量份的组分：The present embodiment 1 provides a composition for improving sleep quality, which comprises the following components by weight:
γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
实施例2Example 2
本实施例2提供了一种改善睡眠质量的组合物，其包括以下重量份的组分：The present embodiment 2 provides a composition for improving sleep quality, which comprises the following components by weight:
γ-氨基丁酸180份、甘氨酸220份、色氨酸60份、L-茶氨酸80份、叶黄素15份、α-胡萝卜素0.65份、蓝莓提取物15份。180 parts of γ-aminobutyric acid, 220 parts of glycine, 60 parts of tryptophan, 80 parts of L-theanine, 15 parts of lutein, 0.65 parts of α-carotene, and 15 parts of blueberry extract.
实施例3Example 3
本实施例3提供了一种改善睡眠质量的组合物，其包括以下重量份的组分：The present embodiment 3 provides a composition for improving sleep quality, which comprises the following components by weight:
γ-氨基丁酸250份、甘氨酸220份、色氨酸80份、L-茶氨酸150份、叶黄素18份、α-胡萝卜素0.75份、蓝莓提取物30份。250 parts of gamma-aminobutyric acid, 220 parts of glycine, 80 parts of tryptophan, 150 parts of L-theanine, 18 parts of lutein, 0.75 parts of alpha-carotene, and 30 parts of blueberry extract.
实施例4Example 4
本实施例4提供了一种改善睡眠质量的组合物，其包括以下重量份的组分：The present embodiment 4 provides a composition for improving sleep quality, which comprises the following components by weight:
γ-氨基丁酸220份、甘氨酸220份、色氨酸40份、L-茶氨酸80份、叶黄素20份、α-胡萝卜素0.75份、蓝莓提取物20份。220 parts of gamma-aminobutyric acid, 220 parts of glycine, 40 parts of tryptophan, 80 parts of L-theanine, 20 parts of lutein, 0.75 parts of alpha-carotene, and 20 parts of blueberry extract.
实施例5Example 5
本实施例5提供了一种改善睡眠质量的组合物，其包括以下重量份的组分：The present embodiment 5 provides a composition for improving sleep quality, which comprises the following components in parts by weight:
γ-氨基丁酸250份、甘氨酸200份、色氨酸55份、L-茶氨酸110份、叶黄素18份、α-胡萝卜素0.8份、蓝莓提取物18份。250 parts of γ-aminobutyric acid, 200 parts of glycine, 55 parts of tryptophan, 110 parts of L-theanine, 18 parts of lutein, 0.8 parts of α-carotene, and 18 parts of blueberry extract.
测试例1Test Example 1
本测试例1利用实施例1-实施例5提供的改善睡眠质量的组合物，分别让20位失眠患者进行服用，连续服用7日，每日早中晚各饮用一次，每次饮用剂量相同，并记录失眠患者在7日后的睡眠改善效果。This Test Example 1 used the compositions for improving sleep quality provided in Examples 1 to 5, respectively, and let 20 insomniacs take them for 7 consecutive days, drinking once a day in the morning, noon and night, and the dosage was the same each time. And record the sleep improvement effect of insomnia patients after 7 days.
测试结果如下所示：The test results are as follows:
服用了实施例1-实施例5提供的改善睡眠质量的组合物的20位失眠患者，所有失眠患者在服用一周后，睡前兴奋、失眠症状以及患者睡醒后的疲惫感得以明显改善。并且，这些失眠患者主诉在睡醒后，不会有困倦等不良感受，而且眼部疲劳症状也得到了明显改善。20 insomnia patients who took the composition for improving sleep quality provided in Example 1-Example 5, all insomnia patients had significant improvement in excitement before going to bed, insomnia symptoms and fatigue after waking up after taking the composition for one week. Moreover, these insomniacs complained that they would not feel sleepy and other bad feelings after waking up, and the symptoms of eye fatigue were also significantly improved.
特别地，服用实施例1提供的改善睡眠质量的组合物的失眠患者，其辅助睡眠，改善失眠症状的效果更加突出。In particular, the insomnia patients who took the composition for improving sleep quality provided in Example 1 had more prominent effects of assisting sleep and improving insomnia symptoms.
测试例2Test case 2
本测试例2还按照中华人民共和国卫生部《保健食品检验与评价技术规范》功能学评价检验方法(改善睡眠功能检验方法)进行动物试验，具体是：直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验；巴比妥钠睡眠潜伏期实验。In this test example 2, animal experiments were also carried out in accordance with the functional evaluation test method (test method for improving sleep function) in the "Technical Specification for Health Food Inspection and Evaluation" of the Ministry of Health of the People's Republic of China, specifically: direct sleep experiment, prolonged pentobarbital sodium sleep Time test, pentobarbital sodium subthreshold dose hypnosis test; barbital sodium sleep latency test.
测试结果如下所示：The test results are as follows:
实施例1-实施例5提供的组合物，均能够明显延长小鼠戊巴比妥钠诱导的睡眠时间，缩短小鼠巴比妥钠睡眠潜伏期，能增加戊巴比妥钠阈下剂量催眠试 验小鼠睡眠动物数。试验表明，实施例1-实施例5提供的组合物具有改善睡眠功能作用。The compositions provided in Example 1-Example 5 can significantly prolong the sleep time induced by sodium pentobarbital in mice, shorten the sleep latency of sodium pentobarbital in mice, and increase the subthreshold dose hypnosis test of sodium pentobarbital Number of sleeping animals in mice. Tests show that the compositions provided in Examples 1-5 have the effect of improving sleep function.
特别地，服用实施例1提供的改善睡眠质量的组合物的小鼠，其辅助睡眠的效果更加突出。In particular, mice taking the composition for improving sleep quality provided in Example 1 had a more prominent effect of assisting sleep.
以上所述仅为本申请的示例性实施例，并不用以限制本申请，凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。The above are only exemplary embodiments of the present application, and are not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application shall be included in the protection of the present application. within the range.

Claims (10)

  1. 一种改善睡眠质量的组合物，其特征在于，所述改善睡眠质量的组合物包括以下重量份的组分：A composition for improving sleep quality, characterized in that the composition for improving sleep quality comprises the following components by weight:
    γ-氨基丁酸150份-250份、甘氨酸150份-250份、色氨酸30份-100份、L-茶氨酸50份-150份、叶黄素10份-20份、α-胡萝卜素0.5份-1.5份、蓝莓提取物10份-30份。Gamma-aminobutyric acid 150-250 parts, glycine 150-250 parts, tryptophan 30-100 parts, L-theanine 50-150 parts, lutein 10-20 parts, α-carrot 0.5-1.5 parts of vegetarian, 10-30 parts of blueberry extract.
  2. 根据权利要求1所述的改善睡眠质量的组合物，其特征在于，所述改善睡眠质量的组合物包括以下重量份的组分：The composition for improving sleep quality according to claim 1, wherein the composition for improving sleep quality comprises the following components by weight:
    γ-氨基丁酸180份-220份、甘氨酸180份-220份、色氨酸40份-60份、L-茶氨酸80份-120份、叶黄素13份-18份、α-胡萝卜素0.5份-1份、蓝莓提取物10份-20份。Gamma-aminobutyric acid 180-220 parts, glycine 180-220 parts, tryptophan 40-60 parts, L-theanine 80-120 parts, lutein 13-18 parts, α-carrot 0.5-1 serving of vegetarian, 10-20 servings of blueberry extract.
  3. 根据权利要求2所述的改善睡眠质量的组合物，其特征在于，所述改善睡眠质量的组合物包括以下重量份的组分：The composition for improving sleep quality according to claim 2, wherein the composition for improving sleep quality comprises the following components by weight:
    γ-氨基丁酸200份、甘氨酸200份、色氨酸50份、L-茶氨酸100份、叶黄素15份、α-胡萝卜素0.75份、蓝莓提取物15份。200 parts of gamma-aminobutyric acid, 200 parts of glycine, 50 parts of tryptophan, 100 parts of L-theanine, 15 parts of lutein, 0.75 parts of alpha-carotene, and 15 parts of blueberry extract.
  4. 一种改善睡眠质量的药物制剂，其特征在于，所述药物制剂包括：权利要求1-3任一项所述的改善睡眠质量的组合物。A pharmaceutical preparation for improving sleep quality, characterized in that, the pharmaceutical preparation comprises: the composition for improving sleep quality according to any one of claims 1-3.
  5. 根据权利要求4所述的改善睡眠质量的药物制剂，其特征在于，所述改善睡眠质量的药物制剂还包括药学上可接受的辅料。The pharmaceutical preparation for improving sleep quality according to claim 4, characterized in that, the pharmaceutical preparation for improving sleep quality further comprises pharmaceutically acceptable excipients.
  6. 根据权利要求5所述的改善睡眠质量的药物制剂，其特征在于，所述药物制剂的剂型为颗粒剂、丸剂、片剂、膏剂、胶囊剂或口服液。The pharmaceutical preparation for improving sleep quality according to claim 5, wherein the pharmaceutical preparation is in the form of granules, pills, tablets, ointments, capsules or oral liquids.
  7. 一种改善睡眠质量的保健食品，其特征在于，所述保健食品包括权利要求1-3任一项所述的改善睡眠质量的组合物。A health food for improving sleep quality, characterized in that, the health food comprises the composition for improving sleep quality according to any one of claims 1-3.
  8. 根据权利要求7所述的改善睡眠质量的保健食品，其特征在于，所述改善睡眠质量的保健食品为固体制剂或者口服液。The health food for improving sleep quality according to claim 7, wherein the health food for improving sleep quality is a solid preparation or an oral liquid.
  9. 根据权利要求8所述的改善睡眠质量的保健食品，其特征在于，所述固体制剂为片剂、胶囊剂、粉剂或者颗粒剂。The health food for improving sleep quality according to claim 8, wherein the solid preparation is tablet, capsule, powder or granule.
  10. 权利要求1-3任一项所述的改善睡眠质量的组合物制备助眠药物或者助眠食品中的应用。Application of the composition for improving sleep quality according to any one of claims 1 to 3 in preparing sleep aid medicine or sleep aid food.
PCT/CN2021/089721 2021-04-25 2021-04-25 Composition for improving sleep quality, pharmaceutical preparation, health supplement, and application WO2022226706A1 (en)

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