WO2022223058A3 - Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof - Google Patents

Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof Download PDF

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Publication number
WO2022223058A3
WO2022223058A3 PCT/CN2022/108071 CN2022108071W WO2022223058A3 WO 2022223058 A3 WO2022223058 A3 WO 2022223058A3 CN 2022108071 W CN2022108071 W CN 2022108071W WO 2022223058 A3 WO2022223058 A3 WO 2022223058A3
Authority
WO
WIPO (PCT)
Prior art keywords
sodium phosphate
phosphate crystal
betamethasone sodium
preparation
method therefor
Prior art date
Application number
PCT/CN2022/108071
Other languages
French (fr)
Chinese (zh)
Other versions
WO2022223058A2 (en
Inventor
肖川
李明丽
Original Assignee
济宁学院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 济宁学院 filed Critical 济宁学院
Priority to PCT/CN2022/108071 priority Critical patent/WO2022223058A2/en
Publication of WO2022223058A2 publication Critical patent/WO2022223058A2/en
Priority to ZA2022/11938A priority patent/ZA202211938B/en
Publication of WO2022223058A3 publication Critical patent/WO2022223058A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

A betamethasone sodium phosphate crystal, and a preparation method therefor and the use thereof. The X-ray powder diffraction of the betamethasone sodium phosphate crystal has characteristic absorption peaks at points where 2θ is 4.430±0.2°, 5.237±0.2°, 6.065±0.2°, 10.149±0.2°, 11.778±0.2°, 14.372±0.2° and 17.624±0.2°. The betamethasone sodium phosphate crystal has the characteristics of high purity and a large particle size, and is stable and can be stored for a long time. The method for preparing the betamethasone sodium phosphate crystal involves a simple process, is easy to carry out, and is suitable for large-scale production.
PCT/CN2022/108071 2022-07-27 2022-07-27 Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof WO2022223058A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2022/108071 WO2022223058A2 (en) 2022-07-27 2022-07-27 Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof
ZA2022/11938A ZA202211938B (en) 2022-07-27 2022-11-02 Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2022/108071 WO2022223058A2 (en) 2022-07-27 2022-07-27 Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof

Publications (2)

Publication Number Publication Date
WO2022223058A2 WO2022223058A2 (en) 2022-10-27
WO2022223058A3 true WO2022223058A3 (en) 2023-01-12

Family

ID=83723746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/108071 WO2022223058A2 (en) 2022-07-27 2022-07-27 Betamethasone sodium phosphate crystal, and preparation method therefor and use thereof

Country Status (2)

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WO (1) WO2022223058A2 (en)
ZA (1) ZA202211938B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103720644A (en) * 2013-08-20 2014-04-16 天津药业集团新郑股份有限公司 Betamethasone sodium phosphate injection
CN105476965A (en) * 2014-09-18 2016-04-13 蚌埠丰原涂山制药有限公司 Method for preparing betamethasone sodium phosphate freeze-dried powder injection
US20190201416A1 (en) * 2015-11-02 2019-07-04 Ajou University Industry-Academic Cooperation Foundation Pharmaceutical composition for treatment of lung cancer comprising glucocorticoid-based compound
CN110964075A (en) * 2018-09-30 2020-04-07 天津药业研究院有限公司 Preparation method of betamethasone phosphate and sodium salt thereof
US20210275451A1 (en) * 2020-03-04 2021-09-09 Somerset Therapeutics Llc Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid
CN113773359A (en) * 2021-09-13 2021-12-10 山东省药学科学院 Preparation and separation method of betamethasone sodium phosphate

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103720644A (en) * 2013-08-20 2014-04-16 天津药业集团新郑股份有限公司 Betamethasone sodium phosphate injection
CN105476965A (en) * 2014-09-18 2016-04-13 蚌埠丰原涂山制药有限公司 Method for preparing betamethasone sodium phosphate freeze-dried powder injection
US20190201416A1 (en) * 2015-11-02 2019-07-04 Ajou University Industry-Academic Cooperation Foundation Pharmaceutical composition for treatment of lung cancer comprising glucocorticoid-based compound
CN110964075A (en) * 2018-09-30 2020-04-07 天津药业研究院有限公司 Preparation method of betamethasone phosphate and sodium salt thereof
US20210275451A1 (en) * 2020-03-04 2021-09-09 Somerset Therapeutics Llc Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid
CN113773359A (en) * 2021-09-13 2021-12-10 山东省药学科学院 Preparation and separation method of betamethasone sodium phosphate

Also Published As

Publication number Publication date
ZA202211938B (en) 2023-01-25
WO2022223058A2 (en) 2022-10-27

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