WO2022198296A1 - Procédé de réduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en œuvre - Google Patents

Procédé de réduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en œuvre Download PDF

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Publication number
WO2022198296A1
WO2022198296A1 PCT/CA2021/050374 CA2021050374W WO2022198296A1 WO 2022198296 A1 WO2022198296 A1 WO 2022198296A1 CA 2021050374 W CA2021050374 W CA 2021050374W WO 2022198296 A1 WO2022198296 A1 WO 2022198296A1
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WO
WIPO (PCT)
Prior art keywords
subject
oxidative stress
powders
shocked
mesh size
Prior art date
Application number
PCT/CA2021/050374
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English (en)
Inventor
John William MANCONI
Original Assignee
Manconi John William
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manconi John William filed Critical Manconi John William
Priority to CA3213011A priority Critical patent/CA3213011A1/fr
Priority to PCT/CA2021/050374 priority patent/WO2022198296A1/fr
Publication of WO2022198296A1 publication Critical patent/WO2022198296A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/1604—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/1619—Thorax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/165—Wearable interfaces

Definitions

  • the present disclosure relates to reducing oxidative stress in a subject, and more particularly to the reduction of oxidative stress in order to treat certain illnesses that are caused or aggravated by oxidative stress.
  • Oxidative stress relates to the imbalance of free radicals and antioxidants in the body, where the free radicals more particularly relate to reactive oxygen species in the body, where the body has difficulty effectively detoxifying the reactive intermediates or to repair the damage caused therefrom.
  • the body produces free radicals during normal metabolic processes. Free radicals are effectively unstable oxygen-containing molecules that have an uneven number of electrons on their outer valence band. In this condition, they effectively act as ionized oxygen molecules.
  • Ionized oxygen molecules are produced naturally when the body breaks down food or is exposed to certain substances.
  • Oxidative stress is dangerous and has a deleterious effect on health because it can damage cells, proteins, and DNA, as well as contributing to ageing, cancer, as well as certain neurodegenerative and life-threatening diseases.
  • Oxidative stress in Parkinson's disease from Peter Jenner DSc, Supplement: Neurogeneration and Prospects for Neuroprotection and Rescue in Parkinson's Disease , Vol. 53, Issue S3, pages. S26-S38, a correlation between Parkinson’s disease and oxidative stress is described.
  • Oxidative stress, aging, and diseases by Liguori et ak, Clin Interv Aging.
  • oxidative stress is related to several age-related conditions, such as cardiovascular diseases, chronic obstructive pulmonary disease chronic kidney disease, neurodegenerative diseases, cancer.
  • cardiovascular diseases such as cardiovascular diseases, chronic obstructive pulmonary disease chronic kidney disease, neurodegenerative diseases, cancer.
  • a solution for reducing oxidative stress may stave off the advancement of such diseases or reduce the aggravation of these diseases.
  • Oxidative stress has also been shown to play a role in traumatic brain injury, such as the one following a collision during a sporting injury, as explained in Toklu et ak, “Chapter 5: Oxidative Stress, Brain Edema, Blood-Brain Barrier Permeability, and Autonomic Dysfunction from Traumatic Brain Injury”, Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects, Boca Raton (FL): CRC Press/Taylor & Francis; 2015
  • the present disclosure relates to the unexpected discovery that a device composed of pure white shocked piezoelectric quartz, when combined with pure metal substances in the form of pure metal powders, can reduce oxidative stress in a subject when applied to a skin of the subject.
  • the device can be used to impede the progress and/or reduce the symptoms of certain diseases and disorders that are caused by or worsened by oxidative stress such as cancer, Alzheimer’s, Parkinson’s, diabetes, myocardial infarction, cardiovascular disease, high blood pressure, atherosclerosis, stroke, neural disorders, lung diseases, rheumatoid arthritis, osteoporosis, chronic fatigue syndrome and asthma.
  • the device includes a titanium catalyst; a selection of pure metal and non-metal powders capable of being ionized including one or more of zinc, silver, copper, titanium, lithium, iron oxide, and graphite; and a conducting substance that serves to embed the latter such as a medical-grade pure silicone resin.
  • the device is normally placed on the body of the subject in direct contact with the skin, and as close as possible to where the body’s heartbeat pulses are strongest.
  • a helmet liner can be made from the composition detailed above, the helmet liner being placed inside a helmet in such a way that the helmet liner contacts the skin covering the wearer’s skull.
  • the pure white shocked piezoelectric quartz in powder form and the pure metal and non-metal substances in the form of pure metal and non-metal powders may be embedded inside a filler material such as medical grade pure silicone resin.
  • the substance may be placed in a pouch or housing made of a conductive material such as cotton (to house the piezoelectric crystal substances), where the pouch or housing does not dampen the anti-oxidative stress properties of the piezoelectric quartz crystal material.
  • the present disclosure introduces an oxidative stress-relieving substance containing piezoelectric crystal material embedded within a filler material (e.g. pure medical-grade silicone resin) that can be placed in contact with skin of a subject.
  • a filler material e.g. pure medical-grade silicone resin
  • This substance helps reduce the subject’s oxidative stress levels by eliminating excess amounts of free radicals in the subject’s body.
  • a sample of the powders used in devices of the present disclosure was obtained from a site in the region of one of Canada’s meteoritic craters. Powders from this site were tested and shown to have the chemical composition of > 99.5% pure silicon dioxide (Si02). The activation energy levels of this shocked quartz can reach levels as high as 20 eV.
  • Ionization energies of metals can vary from 6 eV to 13.5 eV.
  • the oxidative stress-relieving devices of the present disclosure may be in the form of necklaces, bracelets back belts, body bands, patches or helmet liners, etc., as described herein, and may include the following materials: pure white, shocked, piezoelectric crystal powder (Si02); pure titanium-doped zirconia powder (Zr02.Ti); pure silver, copper, titanium, lithium, zinc, iron oxide, and graphite powders.
  • catalyst may be ZrCk.Ti.
  • first predetermined mesh size may be equal to or substantially equal to the second predetermined mesh size.
  • the piezoelectric shocked quartz material may be 99.5% pure quartz (SiCk).
  • the filler material may be pure silicone resin.
  • the device may be in the form of a necklace, bracelet, back belt, body band, pad, or helmet liner.
  • the filler material may be a cream with zinc oxide.
  • the filler material may be a yarn used in a fabric.
  • the device may be an article of clothing comprising the fabric.
  • the one or more metal powders may include one or more of: zinc, silver, copper, titanium, lithium, and iron oxide.
  • the first predetermined mesh size may be between 50 and 500 mesh.
  • the first predetermined mesh size may be approximately 300 mesh.
  • Some embodiments of the oxidative-stress-relieving device may be worn around the wrist as a bracelet. Some embodiments may be also worn around the neck as a necklace. Some embodiments may be worn on the back. Some embodiments may be worn on the chest or breast near the lung and/or heart. In some other embodiments the crystal material, catalysts and metal powders may be mixed with a pure zinc oxide medicinal preparation to create a cream that can be applied to parts of the body that are difficult to access or are locally inflamed.
  • a broad aspect is a wearable device for reducing or preventive at least one of oxidative stress and/or inflammation in a subject.
  • the device has a shocked piezoelectric quartz material composed of at least 99.5% silicone dioxide, of a predetermined mesh size; a catalyst powder of a second predetermined mesh size composed of titanium - doped zirconia (Zr02.Ti); a selection of one or more powders capable of being ionized selected from one or more of silver, copper, titanium, lithium, iron oxide, zinc and graphite; and a filler material that embeds therein the piezoelectric shocked quartz material, the catalyst powder, and the one or more metal and non- metal powders.
  • a shocked piezoelectric quartz material composed of at least 99.5% silicone dioxide, of a predetermined mesh size
  • a catalyst powder of a second predetermined mesh size composed of titanium - doped zirconia (Zr02.Ti)
  • Zr02.Ti titanium - doped zirconia
  • the first predetermined mesh size may be equal to or substantially equal to the second predetermined mesh size.
  • the filler material may be pure silicone resin.
  • the device may be in a form of a necklace, a bracelet, a back belt, a body band or a helmet liner.
  • the device may include a fastener on either end of the necklace for causing both ends of the necklace to connect and secure around a neck of the subject.
  • the fastener may be a hook-and-loop fastener.
  • the device may be a helmet liner.
  • the one or more powders may include one or more of: silver, copper, titanium, lithium, iron oxide and zinc.
  • the first predetermined mesh size may be approximately 300 mesh (50 microns).
  • the contacting may include wearing the composition as at least part of a necklace around a neck of the subject.
  • the composition may be contained in a liner of a helmet, and wherein the contacting occurs when the subject wears the helmet.
  • Figure 3 is a drawing of a cross-section of the exemplary helmet of Figure 2.
  • the present disclosure relates generally to oxidative stress-relieving compositions and devices containing shocked pure piezoelectric quartz powder material (SiCk), a catalyst such as pure titanium-doped zirconia (ZrCk.Ti), and a selection of one or more pure powders (such as Ag, Ti, Cu, Zn, Li, Fe203) and graphite, capable of being ionized - all embedded in a filler material such as pure medical-grade silicone resin or embedded in a cream or a fabric yarn.
  • a subject e.g.
  • the device containing oxidative stress-relieving substances is normally placed on the surface of the body. Necklaces may be fastened around the neck, the wrist, or back using fasteners. On other parts of the body, the oxidative stress-relieving device in the form of a pad that can be attached to the body using a cotton sheath support system or fastened to the body as a back belt or body band by using a Velcro fastening system attached to the cotton sheaths. The device may also be placed on the head as a helmet liner inside helmets.
  • pure white shocked piezoelectric quartz it is meant a material that is at least 99.5% pure white, shocked, piezoelectric quartz.
  • treatment it is meant one or more of (i) preventing at least partially oxidative stress, (ii) inhibiting or arresting at least part of oxidative stress (temporarily or permanently) and (iii) relieving part or all of oxidative stress (temporarily or permanently).
  • the device may have a cotton casing or portion used to surround a body part of a subject.
  • Oxidative stress-relieving devices in the form of necklaces, bracelets or back belts may be manufactured in different lengths depending on the circumference of the wearer’s neck, wrist or waist.
  • the two ends of a necklace may be connected by a nickel and cadmium- free, non-allergenic metal clasp 101 or other similar passive non-allergenic fastening device, such as a hook and loop fastener, as shown in Figure 1.
  • the Tyler Equivalent Mesh size classification is a well-known mesh size classification system created by the W.S. Tyler screening company based in Mentor, Ohio, USA. Mesh size should be understood as being the number of openings per (linear) inch of mesh and is well known in the art. The Tyler scale is used for the purpose of describing the present disclosure.
  • the helmet liner layer 140 may be used to avoid or reduce traumatic brain injury, as described herein, associated with oxidative stress.
  • oxidative stress such as diabetes, cancer (e.g. breast cancer; kidney cancer), osteoporosis, vascular disorders.
  • ESR Erythrocyte Sedimentation Rate
  • the following study is a qualitative study, where patients with diseases attributable to oxidative stress were monitored prior to and after the wearing of the device of the present disclosure and evaluated qualitatively by a medical practitioner to assess worsening or improvement of the condition. Due to the qualitative nature of the present study, the purpose of this study is to supplement and further contextualize the results of exemplary study 1.
  • the 85 subjects were provided with a device (e.g. necklace; bracelet; back belt; cream) comprising super-shocked piezoelectric quartz, a titanium catalyst, and a selection of powders capable of being ionized including one or more of zinc, silver, copper, titanium, lithium, iron oxide, and graphite.
  • a device e.g. necklace; bracelet; back belt; cream
  • powders capable of being ionized including one or more of zinc, silver, copper, titanium, lithium, iron oxide, and graphite.
  • the amount of each of the aforementioned powders embedded inside the silicone resin should be approximately equal to 2% of the total combined weight of the powder and resin mix.
  • the powders are embedded in a silicone resin shaped as a necklace, bracelet, back belt or body band, and worn around the neck, wrist, waist or other parts of the body such as the thigh, as in exemplary study 1.
  • Table 3 Overview of scores for changes in the monitored condition given by a medical practitioner before and after wearing the device.
  • certain of the conditions monitored may have improved independently of the presence of the device, as the factors causing the condition dissipate (e.g. the stress factors; the bacteria or infectious agent).
  • the factors causing the condition dissipate e.g. the stress factors; the bacteria or infectious agent.
  • the patients have experienced at least an overall measurable improvement of the monitored conditions associated with oxidative stress, further indicating, in combination with the results of exemplary study 1, that the device play s a role in improving the subj ecf s well being with regard to conditions attributable to oxidative stress and/or inflammation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Dental Preparations (AREA)
  • Adornments (AREA)

Abstract

Dispositif de réduction du stress oxydatif et/ou de l'inflammation chez un sujet ; comportant un matériau de quartz piézoélectrique ayant subi un choc, d'au moins 99,5 % de pureté de dioxyde de silicium, d'une taille de maille prédéterminée ; une poudre de catalyseur d'une seconde taille de maille prédéterminée composée de zircone dopée au titane (ZrCh.Ti) ; une sélection d'une ou de plusieurs poudres pouvant être ionisées ; et un matériau de charge qui incorpore ledit matériau de quartz piézoélectrique ayant subi un choc et ladite ou lesdites poudres ; ainsi qu'un procédé d'utilisation associé.
PCT/CA2021/050374 2021-03-22 2021-03-22 Procédé de réduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en œuvre WO2022198296A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3213011A CA3213011A1 (fr) 2021-03-22 2021-03-22 Procede de reduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en ?uvre
PCT/CA2021/050374 WO2022198296A1 (fr) 2021-03-22 2021-03-22 Procédé de réduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en œuvre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2021/050374 WO2022198296A1 (fr) 2021-03-22 2021-03-22 Procédé de réduction du stress oxydatif chez un sujet et dispositifs permettant sa mise en œuvre

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WO2022198296A1 true WO2022198296A1 (fr) 2022-09-29

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2075674A1 (fr) * 1992-08-10 1994-02-11 Carmen Miranda Barcon Bracelet therapeutique
CN1416925A (zh) * 2002-11-21 2003-05-14 北京仁德盛科技有限责任公司 可调整发射路径的超声肿瘤治疗机换能器
WO2012083458A1 (fr) * 2010-12-21 2012-06-28 Tpp Energy Solutions Inc. Matériau piézoélectrique destiné à absorber les vibrations
FR3067909A1 (fr) * 2017-06-27 2018-12-28 H.T. Consultant, S.A.R.L. Bijou, ensemble de bijoux et procede de fabrication d'un bijou
WO2020024041A1 (fr) * 2018-08-01 2020-02-06 Manconi John William Dispositif rempli de cristaux piézoélectriques de soulagement de la douleur et procédé d'utilisation correspondant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2075674A1 (fr) * 1992-08-10 1994-02-11 Carmen Miranda Barcon Bracelet therapeutique
CN1416925A (zh) * 2002-11-21 2003-05-14 北京仁德盛科技有限责任公司 可调整发射路径的超声肿瘤治疗机换能器
WO2012083458A1 (fr) * 2010-12-21 2012-06-28 Tpp Energy Solutions Inc. Matériau piézoélectrique destiné à absorber les vibrations
FR3067909A1 (fr) * 2017-06-27 2018-12-28 H.T. Consultant, S.A.R.L. Bijou, ensemble de bijoux et procede de fabrication d'un bijou
WO2020024041A1 (fr) * 2018-08-01 2020-02-06 Manconi John William Dispositif rempli de cristaux piézoélectriques de soulagement de la douleur et procédé d'utilisation correspondant

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