WO2022196798A1 - Device for controlling biometric function via light stimulation and operation method thereof - Google Patents

Device for controlling biometric function via light stimulation and operation method thereof Download PDF

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Publication number
WO2022196798A1
WO2022196798A1 PCT/JP2022/012620 JP2022012620W WO2022196798A1 WO 2022196798 A1 WO2022196798 A1 WO 2022196798A1 JP 2022012620 W JP2022012620 W JP 2022012620W WO 2022196798 A1 WO2022196798 A1 WO 2022196798A1
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Prior art keywords
light
light source
living body
specific wavelength
irradiating
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PCT/JP2022/012620
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French (fr)
Japanese (ja)
Inventor
元詞 早野
一男 坪田
靖恵 満倉
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株式会社坪田ラボ
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Application filed by 株式会社坪田ラボ filed Critical 株式会社坪田ラボ
Priority to EP22771543.0A priority Critical patent/EP4309728A1/en
Priority to KR1020237035257A priority patent/KR20230158655A/en
Priority to CN202280022730.4A priority patent/CN116997390A/en
Priority to JP2023507199A priority patent/JPWO2022196798A1/ja
Publication of WO2022196798A1 publication Critical patent/WO2022196798A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M21/02—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light

Definitions

  • the present invention provides a device and method for controlling biological functions, a device and method for promoting increase in tear volume, and a device and method for improving sleep efficiency or sleep quality by light stimulation by irradiating light of a specific wavelength such as violet light at a specific flickering frequency.
  • a specific wavelength such as violet light at a specific flickering frequency.
  • blood glucose concentration reduction or increase suppression device and method weight gain suppression device and method, cerebral blood flow and cerebral oxygen concentration increase enhancement device and method, and light environment improvement device and method.
  • Non-Patent Document 1 exposure to sunlight improves circadian rhythms (Non-Patent Document 1), and light emitted from LED lighting and liquid crystal displays using LEDs as backlights has a significant effect on the body and mind (Non-Patent Document 1). 2) It has been reported that violet light prevents myopia and suppresses the onset of myopia (Patent Document 1). Particularly recently, the present inventors have made interesting reports about the effects of violet light on the eyes. It has been proposed that the myopia population is still increasing worldwide, and there are great expectations in recent years.
  • the present invention is based on the findings that the inventors have found that irradiation with light of a specific wavelength, especially violet light (visible light in the range of 360 to 400 nm), at a blinking frequency causes various effects on living organisms. It is the result obtained by further investigation, and the purpose is a biological function control device and method by optical stimulation by irradiating light of a specific wavelength such as violet light at a constant light or a specific blinking frequency, and an increase in the amount of lacrimal fluid.
  • a specific wavelength especially violet light (visible light in the range of 360 to 400 nm)
  • the purpose is a biological function control device and method by optical stimulation by irradiating light of a specific wavelength such as violet light at a constant light or a specific blinking frequency, and an increase in the amount of lacrimal fluid.
  • An object of the present invention is to provide an increase promoting device and method, a parasympathetic nerve activation promoting device and method, and a light environment improving device and method.
  • Another object of the present invention is to improve or prevent a disease or condition related to tear volume, improve or prevent a disease or condition related to sleep efficiency or sleep quality by irradiating a violet light with a constant light or a specific blinking frequency.
  • amelioration or prevention, amelioration or prevention of diseases or conditions related to blood glucose level, amelioration or prevention of diseases or conditions related to body temperature, amelioration or prevention of diseases or conditions related to body weight, cerebral blood flow and cerebral oxygen concentration The purpose of the present invention is to provide a method or device for amelioration or prevention of diseases or conditions related to the parasympathetic nervous system, and amelioration or prevention of diseases or conditions related to parasympathetic nerves.
  • a further object of the present invention is to provide a method and apparatus for improving the indoor environment by irradiating light of a specific wavelength such as violet light at a constant light or at a specific flickering frequency.
  • the apparatus for controlling biological functions by optical stimulation is an apparatus for controlling biological functions by irradiating a living body (for example, mammals including humans) with light of a specific wavelength at a constant light or a specific blinking frequency
  • the apparatus is characterized by comprising a light source that emits the light of the specific wavelength at a constant light or at a specific flickering frequency, and a controller that controls emission of the light that controls the biological function of the living body that receives the light.
  • the control of biological function is control of body temperature, body temperature control, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control , control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation, but are not limited thereto.
  • various stimuli can be given to the living body or the functions of the living body can be enhanced by controlling the irradiation state of the light. can.
  • a disease or condition related to biological functions it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom.
  • the light is, for example, violet light.
  • the living body can be irradiated with violet light having a wavelength outside the visible light range, so that the living body can be affected without feeling the flicker or glare of white light.
  • Violet light is light with a wavelength of 360 to 400 nm, which has a lower visual sensitivity than white light and is in a wavelength range that does not or hardly gives discomfort to living organisms (especially humans).
  • light with a wavelength in the range of 350-400 nm such as light with a wavelength of any of 350 nm, 360 nm, 370 nm, 380 nm, 390 nm or 400 nm, or any wavelength defined above Any wavelength of light that falls within the range (eg, 370-390 nm range) may be used.
  • the wavelength includes about 380 nm.
  • the term "about" used in this specification means to include 5% before and after the numerical value modified by this term.
  • the light irradiation state is a constant light (that is, 0 Hz) or a blinking frequency of over 0 Hz to 150 Hz.
  • constant (0 Hz) light or flashing frequency light in the range of 30-75 Hz e.g. Light with any flash frequency of 75 Hz, or any flash frequency within the range defined by any of the above flash frequencies (eg, 35-45 Hz range) may be used.
  • the blinking frequency is approximately 40 Hz.
  • the light can be irradiated with an irradiance of, for example, 0.5 to 1000 ⁇ W/cm 2 .
  • an irradiance of, for example, 0.5 to 1000 ⁇ W/cm 2 .
  • the control unit controls the irradiation state of the light (including constant light or blinking frequency), irradiance, irradiation time, and the like by transmitting and receiving with an isolation controller such as a mobile terminal. It can be executed by changing irradiation conditions such as irradiation start time, irradiation end time, constant light or flashing frequency.
  • the various irradiation conditions described above are controlled in isolation so that irradiation conditions suitable for producing biofunction control can be arbitrarily set to achieve the desired effect. Furthermore, it is possible to measure and evaluate how irradiation of light with a specific wavelength at a flickering frequency or the like affects biological functions, and to what extent the effects on the mind and body are, and apply the results to practical use.
  • the light source may be spectacles with a light source (see, for example, FIG. 2), a spectacle frame, a desktop light source, or a light source installed near the face, such as a light source attached to a mobile terminal.
  • a light source installed in front of or near the face, such as spectacles with a light source or a spectacle frame that is easy to wear and does not cause discomfort on a daily basis. You can always irradiate even in difficult scenes and environments.
  • the light source may be a non-installed light source such as a portable light source, or an installed light source such as a room lighting, table lamp, or dedicated device. Since the biological function control device according to the present invention can induce, for example, an improvement in sleep efficiency or sleep quality, it can be used in the form of a bedside desk light, reading light, desk lighting, wall-mounted lighting, ceiling light, or the like. may be According to some embodiments, the device can have various light source forms depending on the usage environment. For example, the light source may be used in combination with glasses, spectacle lenses, or contact lenses that allow violet light to pass through. Alternatively, sunlight passing through glasses, spectacle lenses, or contact lenses that allow violet light to pass through may be used as a light source.
  • the method for controlling biological functions by light stimulation is a method for controlling biological functions by irradiating a living body (for example, mammals including humans) with light of a specific wavelength at a constant light or a specific blinking frequency, It is characterized by controlling the emission of light that controls the function of the living body that receives the light.
  • a biological function control device is a device for improving or preventing a biological function by irradiating a living body with constant violet light, comprising: a light source emitting the violet light; and a light emission time control unit that emits light for a specific period.
  • the specific time of light irradiation is any time in the range of 10 seconds to 24 hours per day, such as 10 seconds, 30 seconds, 45 seconds, 1 minute, 3 minutes, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, It can be any time of 12 hours, 18 hours, 24 hours, or any time within the range defined by any of the above (eg, 1 to 12 hours).
  • the specific period of continued light irradiation is, for example, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months, It can be for a period of 1 year, 2 years, 3 years or more.
  • a device and method for promoting increased tear volume a device and method for improving sleep efficiency or sleep quality, a blood glucose level, Reduction or increase suppressing device and method, body temperature reduction promoting device and method, weight gain suppressing device and method, parasympathetic nerve activation promoting device and method, cerebral blood flow and cerebral oxygen concentration increasing promoting device and method, light environment improving device and A method is provided.
  • FIG. 10 is a graph showing body temperature of mice illuminated with or without the addition of violet light.
  • the bar graph on the left shows the body temperature of 70-week-old mice.
  • FIG. 4 is a diagram showing Oxy-Hb variation before and after violet light irradiation (upper) and Oxy-Hb dispersion during violet light irradiation (lower).
  • FIG. 3 is a graph showing reduction in blood glucose over a week by violet light irradiation. Changes in glucose mean are shown.
  • Fig. 3 is a graph showing reduction in blood glucose over a week by violet light irradiation. Changes in glucose maxima are shown.
  • FIG. 4 is a diagram showing the average distribution of cerebral blood flow dynamics; Changes in oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration are shown.
  • Figure 18 is a graph quantifying the measurements of Figure 17; Changes in oxygenated hemoglobin concentration, oxygenated hemoglobin concentration, and deoxygenated hemoglobin concentration are shown.
  • Apparatus and method for controlling biological functions by light stimulation according to the present invention apparatus and method for promoting increase in tear volume, apparatus and method for improving sleep efficiency or quality of sleep, apparatus and method for suppressing blood glucose level reduction or increase, suppression of weight gain according to the present invention
  • a device and method, a device and method for promoting an increase in cerebral blood flow and cerebral oxygen concentration, and a device and method for improving a light environment will be described with reference to the drawings.
  • the present invention is not limited to the following embodiments and examples, and includes various modifications and applications within the scope of the present invention.
  • a device for controlling biological functions by optical stimulation is a device for controlling biological functions by irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, wherein the light with the specific wavelength is always lit or It is characterized by comprising a light source that emits light at a specific flickering frequency, and a control unit that controls emission of light that induces control of biological functions of the living body that receives the light.
  • This biological function control device can apply various stimuli to the living body by controlling the state of light irradiation. In particular, by influencing a disease or condition related to biological functions, it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom.
  • the control of biological function is control of body temperature, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control, sleep efficiency or It relates to, but is not limited to, control of sleep quality, control of cerebral blood flow and cerebral oxygenation.
  • irradiation of light in an irradiation state such as a flashing frequency, sound, vibration, magnetic field, electric field, etc. can be applied together, and a combined action of both can be produced.
  • the biological function control device is, as described above, a device for controlling a biological function by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light a light source that emits light, a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period, It is characterized in that it is a device used to control the
  • the biological function control device is a device for controlling a biological function by irradiating a living body with constant violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the biological function control device includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body.
  • the present invention relates to a device for controlling biological function by light stimulation, which is light of a specific wavelength that produces a biological function controlling effect by irradiation.
  • an apparatus comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • the wavelength of light emitted by the light source is not particularly limited, but violet light defined as 360-400 nm is used in some embodiments.
  • a light source whose oscillation frequency can range from 0 (ordinary light, DC light) to 150 Hz can be preferably applied.
  • the frequency can be adjusted in units of 0.5 Hz or 1 Hz by setting the control section, and light with any flickering frequency can be generated.
  • Increasing the blinking frequency also has the advantage that the blinking becomes less annoying, although there are individual differences.
  • the blinking frequency is not limited to 10 Hz or 60 Hz used in the experimental examples.
  • the irradiance from the light source may be variable or constant. In some embodiments, but not limited to, a maximum power of 310 ⁇ W/cm 2 is used. For example, in the range of 1 ⁇ W/cm 2 (0.01 W/m 2 ) to 1000 ⁇ W/cm 2 (10 W/m 2 ), or in the range of 0.5 ⁇ W/cm 2 (0.005 W/m 2 ) to 500 ⁇ W/cm 2 (5 W/m 2 ) or 0.5 to 1000 ⁇ W/cm 2 . Furthermore, a light source with such irradiance can be easily applied to spectacles or spectacle frames, or other portable illumination devices, so that they can be worn in daily life. In particular, it has been confirmed that even a very small amount of weak light (light with low photosensitivity) causes a characteristic phenomenon. ) can be expected to be applied.
  • the light may be specified by relative luminosity. Since the features of the present invention can be realized even with a low relative luminous efficiency, it is possible to irradiate a blinking violet light that causes stimulation to the living body under the low relative luminous efficiency, and to stimulate a desired part without burdening the living body. can be done.
  • the light irradiation time is preferably set arbitrarily according to the purpose, and may be short or long.
  • the light can optionally be intermittent (regular or irregular) or continuous.
  • the light irradiation time can be set, for example, between 8:00 am and 1:00 pm, between 9:00 am and 12:00 am, or between 10:00 am and 11:00 am. can be at least 10 minutes, at least 15 minutes, at least 20 minutes, at least 30 minutes, at least 1 hour, at least 2 hours, at least 3 hours, at least 4 hours, or 5 hours. In some embodiments, 3 hours of irradiation between 9:00 am and 12:00 am or 2 hours of irradiation between 9:00 am and 11:00 am is applied.
  • a timer function can be used for such irradiation with a set time.
  • the light source can be spectacles with a light source or a spectacle frame. Such spectacles or spectacle frames are easy to wear and have a light source that emits a blinking frequency attached to the spectacles or spectacle frames that do not cause discomfort on a daily basis.
  • the light source may be a light source installed in front of or near the face, such as a desk light source or a light source attached to a mobile terminal, or a non-installed light source such as a portable light source, or an indoor lighting, a desk stand, a dedicated device, or the like.
  • the light source may be an installation type light source, and the device may have various light source forms according to the usage environment.
  • the control unit is a part that controls the irradiation state of light from the light source (normal light or flashing frequency).
  • the controller may include a power source for powering the light source, such power source may be a battery or routed by cable to a battery mounted in another location. good too. Moreover, when it does not move in one place, the form connected to a household power supply etc. may be sufficient.
  • the control unit changes the irradiation conditions such as the blinking frequency of the light, the irradiance, the irradiation time, the irradiation start time, the irradiation end time, the blinking frequency, etc. is preferred. Since such a control unit isolates and controls the various irradiation conditions described above, it is possible to arbitrarily set irradiation conditions suitable for producing desired biological function control and obtain desired effects. Furthermore, it is possible to measure and evaluate how irradiation of light with a specific wavelength at the flickering frequency affects biological functions and the extent of the effect on the mind and body, and apply this to practical use.
  • control unit may have a light source controller and a timer function.
  • the controller can include functions such as changing the frequency and irradiance and setting the irradiation time.
  • timer function can be exemplified by one that can set the irradiance time of light. Such a controller and timer function may be provided integrally with the instrument, or may be provided as separate members.
  • FIG. 5 shows a simplified block diagram of an example of the device that can be used for the above-described biological function control.
  • the device shown in FIG. 5 includes the biological function control device described herein, a tear volume increase promotion device, a sleep efficiency or sleep quality improvement device, a blood glucose level reduction or increase suppression device, and a body temperature reduction promotion device. , weight gain suppression device, parasympathetic nerve activation device, cerebral blood flow and cerebral oxygen concentration increase promotion device, and light environment improvement device (these can be collectively referred to simply as “biological function control device”). , and thus all the devices described herein above can be represented by the block diagram of FIG.
  • the biological function control device can have a light source 10 and a controller 20 .
  • the light source 10 emits light of a specific wavelength.
  • the wavelength of the light emitted by the light source 10 preferably includes VL or 350 to 400 nm, and more preferably includes 380 nm.
  • the light source 10 may be any light source, and a light emitting diode (LED) can be preferably used from the viewpoint of small size, long life, and ease of blinking control (an example of the spectrum of a violet fluorescent lamp is shown in FIG. 3, LED (see Figure 4 for an example of the spectrum of ).
  • the number of light sources 10 may be one or more depending on the target irradiation intensity and irradiation range of the light sources.
  • the control unit 20 is wired or wirelessly connected to the light source 10 and configured to control the irradiation conditions of the light source 10 .
  • the irradiation conditions can include at least one of the blinking frequency and the irradiation time of the light source 10, and therefore the control unit 20 can include at least one of the blinking frequency control unit 20a and the irradiation time control unit 20b.
  • the blinking frequency may preferably be 0 Hz or 30-75 Hz, more preferably 0 Hz or 35-45 Hz, particularly preferably 0 Hz or 40 Hz.
  • the flashing frequency of 0 Hz means a constant light.
  • the irradiation time can be arbitrarily determined, for example, in the range of 10 seconds to 24 hours per day, and the specific period of continuation of irradiation can also be arbitrarily determined, for example, from one day to several years or longer. .
  • the control unit 20 can include a processor such as a CPU (Central Processing Unit) and executes processing for controlling the irradiation conditions of the light source 10 .
  • the processing performed by the control unit 20 may be implemented by a computer program or by hardware based on logic circuits.
  • the computer program may be stored on a computer-readable recording medium.
  • a recording medium storing a computer program may be a non-transitory recording medium.
  • the non-transitory recording medium is not particularly limited, and may be, for example, a memory card, CD-ROM, or other recording medium.
  • a computer program stored in a recording medium can be implemented in a computer unit via an appropriate reader. Appropriate readers include, for example, a card reader when the recording medium is a memory card, and a CD drive when the recording medium is a CD-ROM.
  • the computer program may be downloaded from an external server to the computer unit via a communication network.
  • the biological function control device includes glasses or a glasses frame on which at least the light source 10 out of the light source 10 and the control unit 20 is attached, a desk light, a mobile terminal, a mobile terminal case, head-mounted items (caps, earphones, etc.) headphones, etc.), portable lights, room lights, or lighted products, including table lamps.
  • the apparatus for controlling biological functions by optical stimulation can control biological functions by irradiating a living body with light of a specific wavelength such as violet light at a constant light or a specific flickering frequency. .
  • a specific wavelength such as violet light at a constant light or a specific flickering frequency.
  • it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom.
  • one aspect of the present invention relates to a method for operating a biological function control device using optical stimulation.
  • some embodiments of the present invention are a method of operating a device for use in controlling a biological function, the device comprising a light source that irradiates a living body with light of a specific wavelength at constant or a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • the computer program according to the present invention may be stored in a non-transitory computer-readable medium.
  • a computer program according to the present disclosure is capable of performing predetermined steps when instructions are executed by a processor.
  • one aspect of the present disclosure is a non-transitory computer-readable medium having instructions stored thereon that, when executed by a processor, emit light of a particular wavelength at all times or at a particular wavelength.
  • a device comprising a light source that irradiates a living body with a flickering frequency and a control unit that controls the flickering frequency of the light source, wherein the control unit controls the flickering frequency of the light source in the range of 0 Hz or 30 to 75 Hz. and operating the device such that the light source irradiates a living body with light in the wavelength range of 350-400 nm.
  • one aspect of the present invention relates to a method for controlling biological functions by optical stimulation. Therefore, some embodiments of the present invention provide a method of controlling a biological function by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, wherein the biological function in the living body receiving the light is is controlled. More specifically, some embodiments of the present invention are a method for controlling a biological function in a subject in need of treatment, comprising directing light of a particular wavelength to the subject at steady on or at a particular blinking rate. A method comprising irradiating a living body with a frequency, whereby a biological function is controlled in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. .
  • Tear volume increase promotion device and method The present inventors further investigated the effect of violet light on tear volume. As a result, it was found that the increase in the amount of tear fluid can be promoted or the decrease can be suppressed by light stimulation by irradiation with violet light. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors completed the method and device for promoting increased tear volume according to the present invention.
  • the tear volume increase promoting device is a device that irradiates a living body with violet light at a constant light or at a specific flickering frequency to promote an increase in tear volume or suppress a decrease in tear volume.
  • a light source that emits the violet light
  • a light emission cycle control unit that sets the violet light to a constant light or a specific blinking frequency
  • a light emission time control unit that irradiates the violet light for a specific time or a specific period. It is a device used for promoting an increase in the amount of tear fluid or suppressing a decrease in the tear fluid volume.
  • the apparatus for promoting tear volume increase is an apparatus for promoting an increase in tear volume by irradiating a living body with normal light of violet light, wherein the violet light emits light. and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the tear volume increase promoting device includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is
  • the present invention relates to an apparatus for promoting tear volume increase by photo-stimulation, which is light of a specific wavelength that produces an effect of promoting tear volume increase by irradiating a living body.
  • an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method for operating an apparatus for promoting tear volume increase by optical stimulation.
  • some embodiments of the present invention are a method of operating a device for use in promoting tear volume augmentation, wherein the device irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for promoting tear volume increase by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to promote an increase in tear volume, A method characterized in that an increase in tear volume is promoted in More specifically, some embodiments of the present invention are a method for promoting increased tear volume in a subject in need of treatment comprising directing a specific wavelength of light to the subject at constant or A method comprising irradiating a living body with a particular flickering frequency, thereby promoting an increase in tear volume in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • a preventive or therapeutic device for corneal diseases configured to irradiate a living body with light of a specific wavelength that produces It also relates to a method of preventing or treating corneal disease comprising the step of More specifically, some embodiments provide a dry eye prophylaxis or treatment device and method of operation configured to irradiate a living body with light of a specific wavelength that produces an effect, or dry eye prophylaxis or treatment.
  • the present invention relates to a method for preventing or treating dry eye, including the step of irradiating a living body with light of a specific wavelength that produces a therapeutic effect.
  • Such devices or methods may be used in combination with therapeutic agents for dry eye or keratoconjunctival epithelial disorders (sodium hyaluronate, diquafosol sodium, etc.).
  • the present inventors further studied the effect of violet light on sleep efficiency or sleep quality. As a result, it was found that light stimulation by irradiation with violet light can improve sleep efficiency or sleep quality. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors completed the method and device for improving sleep efficiency or sleep quality according to the present invention.
  • the device for improving sleep efficiency or sleep quality according to the present invention is a device for improving sleep efficiency or sleep quality by irradiating a living body with violet light at a constant light or at a specific flickering frequency.
  • a light source that emits the violet light
  • a light emission cycle control unit that sets the violet light to a constant light or a specific blinking frequency
  • a light emission time control unit that irradiates the violet light for a specific time or a specific period. and is a device used for improving sleep efficiency or quality of sleep.
  • the sleep efficiency or sleep quality improvement device is a device for improving sleep efficiency or sleep quality by irradiating a living body with constant violet light, It is characterized by comprising a light source that emits violet light, and a light emission time control section that irradiates the violet light for a specific time or for a specific period.
  • the sleep efficiency or sleep quality improvement device also includes at least one light source that emits light, and a driving circuit that drives the light source, and the light source emits The light is light of a specific wavelength that produces an effect of improving sleep efficiency or sleep quality by irradiating the living body.
  • an apparatus comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method of operating a device for improving sleep efficiency or sleep quality by light stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in improving sleep efficiency or quality, wherein the device emits light of a specific wavelength to the body at a constant or a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for improving sleep efficiency or sleep quality by light stimulation. Therefore, some embodiments of the present invention provide a method for improving sleep efficiency or sleep quality by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, A method characterized in that sleep efficiency or sleep quality is improved in vivo. More specifically, some embodiments of the present invention provide a method for improving sleep efficiency or sleep quality in a subject in need of treatment comprising exposing the subject to constant light of a particular wavelength. or irradiating a living body with a particular flickering frequency, whereby sleep efficiency or sleep quality is improved in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention is to produce an effect of preventing or treating sleep disorders and related diseases.
  • Devices for preventing or treating sleep disorders and diseases related thereto configured to irradiate a living body with light of specific wavelengths, and operating methods thereof, or lights of specific wavelengths that produce preventive or therapeutic effects for sleep disorders and diseases related thereto It also relates to a method for preventing or treating sleep disorders and related diseases, including the step of irradiating the living body with More specifically, some embodiments are a sleep disorder preventive or therapeutic device configured to irradiate a living body with light of a specific wavelength that produces a sleep disorder preventive or therapeutic effect, and a method of operating the same.
  • the present invention relates to a method for preventing or treating sleep disorders, which includes the step of irradiating a living body with light of a specific wavelength that produces sleep disorder preventive or therapeutic effects.
  • sleep disorders Such devices or methods may be used in combination with hypnotics (benzodiazepines, brotizolam, estazolam, quazepam, etc.).
  • some embodiments are directed to a device for eliminating jet lag configured to irradiate a living body with light of a specific wavelength that produces an effect of eliminating jet lag such as jet lag, and a method of operating the same, or an effect of eliminating jet lag.
  • It relates to a method for eliminating jet lag, which includes the step of irradiating a living body with light of a specific wavelength that causes
  • some embodiments are configured to irradiate the living body with light of a specific wavelength that produces a sleep-inducing effect, such as a night shift, which allows people who work at night to fall asleep earlier.
  • the present invention relates to an inducing device and its operating method, or to a sleep inducing method including the step of irradiating a living body with light of a specific wavelength that produces a sleep inducing effect.
  • some embodiments also include a drowsiness suppressor configured to irradiate a living body with light of a specific wavelength that produces a drowsiness suppressing effect that prevents a person working at night, such as a night shift, from falling asleep. It also relates to a device and a method of operating the same, or a drowsiness-suppressing method comprising irradiating a living body with light of a specific wavelength that produces a drowsiness-suppressing effect.
  • the blood glucose level reduction or increase suppression device is a device for reducing or increasing blood glucose level by irradiating a living body with violet light at a constant light or at a specific flickering frequency.
  • a light source that emits the violet light
  • a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency
  • a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the blood glucose level reduction or increase suppression device is a device for reducing or increasing the blood glucose level by irradiating a living body with constant violet light. and a light source for emitting the violet light, and a light emission time control section for emitting the violet light for a specific time or for a specific period.
  • the blood glucose level reduction or increase suppression device includes at least one light source that emits light and a drive circuit that drives the light source, and the light source is The emitted light is light of a specific wavelength that produces an effect of reducing or increasing the blood glucose concentration by irradiating the living body.
  • an apparatus comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method of operating a device for reducing or increasing blood glucose concentration by light stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in improving sleep efficiency or quality, wherein the device emits light of a specific wavelength to the body at a constant or a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for reducing or suppressing an increase in blood glucose concentration by light stimulation. Therefore, some embodiments of the present invention provide a method for reducing or suppressing an increase in blood glucose level by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, wherein It relates to a method, characterized in that the blood glucose level is reduced or inhibited from increasing in said living body. More specifically, some embodiments of the present invention are methods for reducing or inhibiting increases in blood glucose levels in a subject in need of treatment, comprising constantly exposing the subject to a specific wavelength of light.
  • a method comprising irradiating a living body with a light or a particular flickering frequency, whereby blood glucose levels are reduced or increased in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention is a diabetes preventive that is configured to irradiate a living body with light of a specific wavelength that produces the preventive effect of diabetes.
  • the present invention also relates to a device and method of operation thereof, or a method of preventing diabetes comprising the step of irradiating a living body with light of a specific wavelength that produces a preventive effect against diabetes.
  • some embodiments are a diabetes prevention device configured to irradiate a living body with light of a specific wavelength that produces a diabetes prevention effect and a method of operating the same, or a specific wavelength that produces a diabetes prevention effect It relates to a diabetes prevention method including the step of irradiating a living body with light of Such devices or methods may be used in combination with blood sugar lowering drugs (insulin, pigguanides, sulfonylureas, thiazolidines, DPP-4 inhibitors, etc.) or foods (supplements). Furthermore, some embodiments are configured to irradiate a living body with light of a specific wavelength that produces a preventive effect for chronic renal disorder, arteriosclerosis, cerebral infarction, and gout.
  • blood sugar lowering drugs insulin, pigguanides, sulfonylureas, thiazolidines, DPP-4 inhibitors, etc.
  • foods supplements
  • some embodiments are configured to irradiate a living body with light
  • Gout preventive device and its operation method or chronic renal disorder, arteriosclerosis, cerebral infarction, chronic renal disorder, arteriosclerosis, cerebral infarction, gout including the step of irradiating a living body with light of a specific wavelength that produces a preventive effect for chronic renal disorder, arteriosclerosis, cerebral infarction, gout concerning the preventive method of
  • Such devices or methods include statins (HMG-CoA reductase inhibitors), fibrates, nicotinic acid derivatives, probucol, ethyl icosapentate (EPA), febuxostat, allopurinol, angiotensin converting enzyme inhibitors, angiotensin receptors. It may be used in combination with drugs such as body antagonists, diuretics, steroids, and the like.
  • the present inventors further conducted research on the effect of violet light on body temperature. As a result, it was found that the photo-stimulation caused by the irradiation of violet light could accelerate the decrease in body temperature. Then, based on the knowledge of such effects of light stimulation by violet light, the inventors have completed the method and apparatus for promoting a decrease in body temperature according to the present invention.
  • the device for promoting body temperature reduction according to the present invention is a device for promoting body temperature reduction by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light is emitted.
  • the device for promoting body temperature reduction according to the present invention is a device for promoting body temperature reduction by irradiating a living body with normal violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the device for promoting body temperature reduction according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body.
  • the present invention relates to a device for promoting body temperature reduction by photo-stimulation, which is light of a specific wavelength that produces an effect of promoting body temperature reduction by irradiation.
  • an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method for operating a device for promoting body temperature reduction by optical stimulation.
  • some embodiments of the present invention are a method of operating a device for use in promoting hypothermia, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for promoting a decrease in body temperature by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to accelerate body temperature reduction, is promoted. More specifically, some embodiments of the present invention provide a method for promoting hypothermia in a subject in need of treatment comprising directing a constant or a particular blinking light of a particular wavelength to the subject. A method comprising irradiating a living body with a frequency, whereby hypothermia is promoted in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention is to irradiate a living body with light of a specific wavelength that produces a preventive effect on aging-related diseases.
  • the present invention also relates to an aging-related disease preventive device configured as described above and an operation method thereof, or an aging-related disease preventive method including a step of irradiating a living body with light of a specific wavelength that produces an aging-related disease preventive effect.
  • some embodiments are directed to an anti-obesity device configured to irradiate a living body with light of a specific wavelength that produces an anti-obesity effect and a method of operating the same, or a specific wavelength that produces an anti-obesity effect It relates to a method for preventing obesity, which includes the step of irradiating a living body with light of Such devices or methods may be used in combination with anti-obesity drugs (Mazindol, Orlistat, etc.) or diet foods (supplements).
  • the weight gain suppression device is a device for suppressing weight gain by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light emits light.
  • the weight gain suppression device is a device that irradiates a living body with constant violet light to promote weight gain suppression, comprising: a light source that emits the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the weight gain suppressing device includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body.
  • the present invention relates to a device for suppressing weight gain using photostimulation, which is light of a specific wavelength that produces a weight gain suppressing effect when irradiated.
  • an apparatus comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method for operating a weight gain suppressing device using optical stimulation.
  • some embodiments of the present invention are a method of operating a device for use in reducing weight gain, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for suppressing weight gain by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to promote suppression of weight gain, wherein the body that receives the light loses weight. It relates to a method, characterized in that the suppression of growth is facilitated. More specifically, some embodiments of the present invention provide a method for promoting weight reduction in a subject in need of treatment, comprising exposing the subject to constant or specific wavelengths of light. A method comprising irradiating a living body with a flickering frequency, thereby promoting suppression of weight gain in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention is a specific
  • the present invention also relates to a metabolic activation device configured to irradiate a living body with light of a wavelength and a method of operating the same, or a metabolic activation method including a step of irradiating a living body with light of a specific wavelength that produces a metabolic activation effect.
  • a fat burning promoting device configured to irradiate a living body with light of a specific wavelength that produces a fat burning promoting effect and an operating method thereof, or a fat burning promoting effect is produced.
  • the present invention relates to a method for promoting fat burning, including the step of irradiating a living body with light of a specific wavelength.
  • a mitochondrial activation device configured to irradiate a living body with light of a specific wavelength that produces a mitochondrial activation effect, and a method of operating the same, or a mitochondrial activation effect. It also relates to a method for activating mitochondria, which includes the step of irradiating a living body with light of a specific wavelength.
  • the parasympathetic nerve activation promoting device is a device for promoting the activation of the parasympathetic nerve by irradiating a living body with violet light at constant light or at a specific flickering frequency, A light source that emits violet light, a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period, and is parasympathetic.
  • the device is characterized by being a device used to promote activation of nerves.
  • the parasympathetic nerve activation device is a device for irradiating a living body with constant light of violet light to promote activation of the parasympathetic nerve, wherein the violet light is emitted. It is characterized by comprising a light source and a light emission time control section for irradiating the violet light for a specific time or for a specific period.
  • the parasympathetic nerve activation device includes at least one light source that emits light, and a drive circuit that drives the light source.
  • the present invention relates to a device for activating a parasympathetic nerve by light stimulation, which is light of a specific wavelength that causes a parasympathetic nerve activation effect by irradiating the device.
  • an apparatus comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method for operating a device for promoting parasympathetic nerve activation by optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in promoting parasympathetic activation, wherein the device irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for promoting parasympathetic nerve activation by light stimulation. Therefore, some embodiments of the present invention provide a method for promoting parasympathetic nerve activation by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, comprising: The present invention relates to a method, characterized in that parasympathetic nerve activation is promoted. More specifically, some embodiments of the present invention provide a method for promoting parasympathetic activation in a subject in need of treatment, comprising directing a constant or specific wavelength of light to the subject.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention is to produce an effect of reducing stress or fatigue in a living body.
  • a stress or fatigue reduction device configured to irradiate a living body with light of a specific wavelength and its operation method, or a stress including a step of irradiating a living body with light of a specific wavelength that produces a stress or fatigue reduction effect Or it also relates to a method for reducing fatigue.
  • some embodiments are a constipation relieving device configured to irradiate a living body with light of a specific wavelength that produces constipation relieving effects, and an operating method thereof, or light of a specific wavelength that produces constipation relieving effects.
  • the present invention relates to a method for relieving constipation, including the step of irradiating a living body.
  • Such devices or methods may be used in combination with laxatives.
  • the apparatus for promoting an increase in cerebral blood flow and cerebral oxygen concentration irradiates a living body with violet light at a constant light or at a specific flickering frequency to increase cerebral blood flow and cerebral oxygen concentration.
  • a light source that emits the violet light
  • a light emission cycle control unit that makes the violet light a constant light or a specific flickering frequency
  • a controller and is a device used to promote an increase in cerebral blood flow and cerebral oxygen concentration.
  • the device for promoting cerebral blood flow and cerebral oxygen concentration increase is a device that promotes an increase in cerebral blood flow and cerebral oxygen concentration by irradiating a living body with normal violet light. and a light source that emits the violet light, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the device for promoting cerebral blood flow and cerebral oxygen concentration increase includes at least one light source that emits light and a drive circuit that drives the light source, and the light source is The emitted light is light of a specific wavelength that promotes an increase in cerebral blood flow and cerebral oxygen concentration by irradiating the living body.
  • an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method for operating a device for promoting cerebral blood flow and cerebral oxygen concentration increase by optical stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in promoting increased cerebral blood flow and cerebral oxygenation, wherein the device emits light of a specific wavelength at constant or at a specific flicker frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates the living body with light of a specific wavelength at a constant light or at a specific flickering frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for promoting an increase in cerebral blood flow and cerebral oxygen concentration by light stimulation. Therefore, some embodiments of the present invention provide a method for promoting cerebral blood flow and cerebral oxygen concentration increase by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, comprising: and cerebral blood flow and increased cerebral oxygen concentration are promoted in said living body. More specifically, some embodiments of the present invention are a method for promoting cerebral blood flow and cerebral oxygenation in a subject in need of treatment comprising directing light of a particular wavelength to the subject.
  • a method comprising irradiating a living body with constant light or a specific flickering frequency, thereby promoting cerebral blood flow and increased cerebral oxygen concentration in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • the light environment improvement device can be used in a living environment even in an environment where it is not possible to take sufficient sunlight or exercise a moderate amount due to continuous remote work at home, for example. It is possible to improve the indoor work environment by having a favorable influence on sleep, blood sugar level, and cerebral blood flow.
  • the optical environment improving device is a device for controlling biological functions by irradiating a living body with violet light at a constant light or at a specific flickering frequency, comprising: a light source emitting the violet light; a constant light or a specific flickering frequency, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period, and is used to improve control of biological functions.
  • the control of biological function is control of body temperature, body temperature control, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control , control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation, but are not limited thereto.
  • the light source may be used in combination with glasses, spectacle lenses, or contact lenses that allow violet light to pass through.
  • sunglasses, spectacle lenses, or contact lenses that allow violet light to pass through may be used as a light source.
  • spectacles or contact lenses using glass that allows violet light to pass through have a higher biological function control effect than spectacles or contact lenses using normal lenses.
  • the optical environment improving device is a device for controlling a biological function by irradiating a living body with normal violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
  • the optical environment improving device includes at least one light source that emits light and a driving circuit that drives the light source, and the light emitted by the light source is delivered to the living body.
  • the present invention relates to a device for improving a light environment by light stimulation, which is light of a specific wavelength that produces a biological function control effect when irradiated.
  • an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
  • one aspect of the present invention relates to a method of operating a device for improving the optical environment by optical stimulation.
  • some embodiments of the present invention are a method of operating a device for use in improving the lighting environment, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a control unit for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency.
  • the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm.
  • one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
  • one aspect of the present invention relates to a method for improving the light environment by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency in order to improve an indoor environment, A method, characterized in that a biological function is controlled in a living organism. More specifically, some embodiments of the present invention are a method for controlling bodily functions in a subject in need of treatment to improve the indoor environment, comprising: It relates to a method comprising the step of irradiating a living body with light at constant light or at a specific flickering frequency, whereby a biological function is controlled in said living body receiving said light.
  • the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
  • one aspect of the present invention relates to a device for improving the light environment by light stimulation, and the device may include glasses, spectacle lenses, or contact lenses that allow violet light to pass through.
  • the use of such devices can positively affect bodily functions.
  • the control of biological functions that can be achieved by using such devices includes the control of body temperature, body temperature control, body weight control, blood glucose concentration control, tear volume control, and parasympathetic nerve activation control. including, but not limited to, control, control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation.
  • Control of other biological functions includes the prevention or treatment of corneal diseases, the prevention or treatment of dry eye, the prevention or treatment of sleep disorders and related diseases, the prevention or treatment of sleep disorders, the elimination of jet lag, the induction of sleep, and drowsiness.
  • violet light is also expressed as "VL”.
  • Violet light used light with a wavelength of 360 to 400 nm, and flashing irradiation was performed within the irradiance range of 0.5 to 1000 ⁇ W/cm 2 .
  • Fig. 13 is a graph showing changes in body temperature from 8 hours before falling asleep. Mean body temperature change (X-axis) and body temperature (Y-axis) for eight subjects are shown. It is considered important for body temperature to drop steadily at sleep onset, indicating that sleep onset is promoted by VL. While Table 2 above is sleep quality data, this one focuses on promoting sleep onset.
  • FIG. 14 is a graph showing changes in body temperature before and after sleep and during wakefulness. They often use PCs and smartphones before going to bed, and their body temperature is often uneven before and after sleep, and such a phenomenon was observed in the control (without VL). With the intervention of VL irradiation, the body temperature stabilizes before sleep and gradually decreases at sleep onset. This suggests that the circadian cycle is in order and sleep onset is promoted.
  • Figures 15 and 16 show the decrease in blood glucose over a week due to violet light irradiation. It was shown in an experiment with a woman in her 40s that daily blood glucose could be controlled by violet irradiation for 3 hours every day. It is understood that the effect can be obtained regardless of age, such as middle-aged people as well as young people.
  • the above results show that the blood glucose concentration can be reduced or suppressed from increasing by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
  • mice Genetically engineered hypothermic mice, calorie-restricted mice, and growth hormone GH-deficient mice are known to have extended lifespans and increased metabolic activity, such as high oxygen consumption relative to body weight (Conti et al. , Science 03 Nov 2006: Vol. 314, Issue 5800, pp. 825-828, DOI: 10.1126/science.1132191; Bartke & Westbrook, Front. Genet., 13 December 2012, https://doi.org/10.3389/ fgene.2012.00288). Violet light stimulation is thought to be able to control weight loss by activating metabolism.
  • weight gain can be suppressed by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
  • a high value indicates sympathetic nerve dominance, and a low value indicates parasympathetic nerve dominance.
  • violet light irradiation reduces the LH/HF ratio, suggesting parasympathetic nerve dominance. From these results, it is understood that irradiation with violet light makes the parasympathetic nervous system dominant, and that relaxation effects, promotion of insulin secretion, and promotion of blood flow can be obtained.
  • the above results show that the activation of the parasympathetic nerve can be promoted by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
  • Fig. 17 shows the average distribution of cerebral hemodynamics, showing a trend of increased deoxygenated hemoglobin in the frontal region. Oxygen consumption is increased in the right hemisphere, suggesting that this technology could be applied to promote creativity, art, and flexibility, and to treat moyamoya disease, apraxia, and agnosia.
  • Fig. 18 supplements the results of Fig. 17 by quantifying the entire frontal lobe. A trend toward decreased oxygenated hemoglobin and increased deoxygenated hemoglobin in the forehead was observed. The numerical values are summarized in Table 6 below.
  • the above results show that the sleep efficiency or sleep quality of a living body can be improved by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
  • (Appendix 1) Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces a biological function control effect when applied to a living body.
  • a biological function control device using stimulation. It has at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is light of a specific wavelength that, when irradiated to a living body, produces an effect of promoting an increase in the amount of tear fluid. , A device that promotes increased tear volume by light stimulation.
  • At least one light source that emits light, and a drive circuit that drives the light source, and the light emitted by the light source has a specific wavelength that improves sleep efficiency or sleep quality when irradiated to a living body.
  • a device for improving sleep efficiency or sleep quality by light stimulation. At least one light source that emits light, and a drive circuit that drives the light source, and the light emitted by the light source has a specific wavelength that causes an effect of reducing or suppressing an increase in blood glucose concentration by irradiating a living body.
  • a light-stimulated blood glucose level reduction or increase inhibitory device is a specific wavelength that causes an effect of reducing or suppressing an increase in blood glucose concentration by irradiating a living body.
  • (Appendix 5) Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that causes a body temperature lowering effect when irradiated to a living body.
  • a device that promotes hypothermia through stimulation. At least one light source that emits light, and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces an effect of suppressing weight gain when applied to a living body.
  • a device for suppressing weight gain by stimulation At least one light source that emits light, and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces an effect of suppressing weight gain when applied to a living body.
  • Device for promoting parasympathetic nerve activation by light stimulation. At least one light source that emits light, and a drive circuit that drives the light source, wherein the light emitted by the light source has a specific wavelength that promotes an increase in cerebral blood flow and cerebral oxygen concentration when applied to a living body.
  • a device for promoting cerebral blood flow and cerebral oxygen concentration increase by optical stimulation.
  • (Appendix 9) Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces a biological function control effect when applied to a living body.
  • Light environment improvement device by stimulation (Appendix 10) 10. The device according to any one of the clauses 1-9, wherein the light is violet light.
  • (Appendix 11) 11. The device according to any one of clauses 1-10, wherein said specific wavelength comprises 350-400 nm. (Appendix 12) 12. The apparatus of Clause 11, wherein the specific wavelength comprises approximately 380 nm. (Appendix 13) 13.
  • control unit controls the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz, and the light source irradiates the living body with light having a wavelength in the range of 350 to 400 nm. including, how it works.
  • Appendix 19 19. The method of operation of claim 18, wherein said specific wavelength is approximately 380 nm.
  • Appendix 20 20. The method of operation according to clause 18 or 19, wherein said particular blinking frequency is 0 Hz or about 40 Hz.
  • 21. A method of operation according to any one of claims 20.
  • (Appendix 24) Irradiate the living body with a violet light at a constant light or a specific blinking frequency, a) for the prevention or treatment of corneal diseases, b) for preventing or treating dry eye, c) for the prevention or treatment of sleep disorders and related diseases; d) to prevent or treat sleep disorders, e) to combat jet lag, f) to induce sleep, g) to suppress drowsiness, h) to prevent diabetes, i) to prevent chronic kidney damage, arteriosclerosis, cerebral infarction, or gout, j) to prevent obesity, k) for preventing aging-related diseases, l) to activate the metabolism, m) to promote fat burning, n) to promote mitochondrial activation, o) to relieve stress or fatigue, or p) to relieve constipation,
  • a device comprising: a light source that emits the violet light; a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency; and a light emission time control unit that
  • (Appendix 25) Irradiate the living body with the constant light of the violet light, a) prevent or treat corneal diseases, b) prevent or treat dry eye, c) prevent or treat sleep disorders and related diseases; d) prevent or treat sleep disorders; e) relieve jet lag, f) induce sleep, g) suppress drowsiness, h) prevent diabetes, i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout; j) prevent obesity, k) prevent aging-related diseases, l) activate metabolism, m) promote fat burning, n) promotes mitochondrial activation; o) reduce stress or fatigue, or p) relieve constipation,
  • a device comprising: a light source that emits the violet light; and a light emission time controller that irradiates the violet light for a specific time or for a specific period.
  • (Appendix 27) a) prevent or treat corneal diseases, b) prevent or treat dry eye, c) prevent or treat sleep disorders and related diseases; d) prevent or treat sleep disorders; e) relieve jet lag, f) induce sleep, g) suppress drowsiness, h) prevent diabetes, i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout; j) prevent obesity, k) prevent aging-related diseases, l) activate metabolism, m) promote fat burning, n) promotes mitochondrial activation; o) reduce stress or fatigue, or p) relieve constipation, A method of operating a device for use in a method for , the control unit controlling the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz; and the light source irradiating the living body with light having a wavelength in the range of 350 to 400 nm.
  • Appendix 28 A computer program for causing an apparatus comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency and a controller for controlling the blinking frequency of the light source to execute the operation method of appendix 26.
  • (Appendix 32) In a subject in need of treatment, a) prevent or treat corneal diseases, b) prevent or treat dry eye, c) prevent or treat sleep disorders and related diseases; d) prevent or treat sleep disorders; e) relieve jet lag, f) induce sleep, g) suppress drowsiness, h) prevent diabetes, i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout; j) prevent obesity, k) prevent aging-related diseases, l) activate metabolism, m) promote fat burning, n) promotes mitochondrial activation; o) reduce stress or fatigue, or p) relieve constipation, comprising glasses, spectacle lenses or contact lenses that allow violet light to pass through.
  • (Appendix 33) A method for producing a biofunction-regulating effect in a subject in need of treatment, the method comprising irradiating the subject with light of a particular wavelength. (Appendix 34) 10. Any of Clauses 1-9, wherein the drive circuitry includes at least one processor communicatively connected to a light source and at least one memory, and at least one memory for storing processor-executable instructions. A device according to claim 1.
  • (Appendix 35) at least one light source that emits light; a driving circuit for driving the light source; has the drive circuitry includes at least one processor communicatively connected to a light source and at least one memory; and at least one memory for storing processor-executable instructions;
  • the light source is configured to emit light of a specific wavelength that produces a biological function control effect by irradiating the living body. Biofunction control device by optical stimulation.

Abstract

The present disclosure relates to: a device and method for controlling biometric function via stimulation by light of a specific wavelength, such as violet light, wherein the light is emitted constantly or blinks at a specific blinking frequency; and a device and method for improving a light environment. An example of the device for controlling biometric function has: at least one light source (10) that emits light of a specific wavelength; and a control unit (20) configured to control emission conditions including the blinking frequency of the light source (10).

Description

光刺激による生体機能制御装置及びその作動方法BODY FUNCTION CONTROL DEVICE USING LIGHT STIMULATION AND METHOD OF OPERATION THEREOF
　本発明は、バイオレットライト等の特定波長の光を特定の点滅周波数で照射した光刺激による生体機能制御装置及び方法、涙液量増加促進装置及び方法、睡眠効率又は睡眠の質の改善装置及び方法、血中グルコース濃度低減又は増加抑制装置及び方法、体重増加抑制装置及び方法、脳血流及び脳酸素濃度増加促進装置及び方法、並びに光環境改善装置及び方法に関する。 The present invention provides a device and method for controlling biological functions, a device and method for promoting increase in tear volume, and a device and method for improving sleep efficiency or sleep quality by light stimulation by irradiating light of a specific wavelength such as violet light at a specific flickering frequency. , blood glucose concentration reduction or increase suppression device and method, weight gain suppression device and method, cerebral blood flow and cerebral oxygen concentration increase enhancement device and method, and light environment improvement device and method.
　光の人体への影響は、近年、様々な観点から検討され、新たな知見に基づいて報告されている。例えば、太陽光を浴びることによりサーカディアンリズムが改善すること（非特許文献１）、ＬＥＤ照明やＬＥＤをバックライトに使用した液晶ディスプレイ等から発する光が身体や心に大きく影響すること（非特許文献２）、バイオレットライトが近視の予防及び近視の発症を抑制すること（特許文献１）等が報告されている。特に最近、本発明者らは、バイオレットライトが眼に及ぼす影響についての興味ある報告をしており、例えば特許文献１及び非特許文献３には、特定波長の光が近視予防と近視抑制に効果的であることが提案され、近視の人口が依然として世界的に増えている近年、大きな期待が寄せられている。 In recent years, the effects of light on the human body have been examined from various perspectives and reported based on new findings. For example, exposure to sunlight improves circadian rhythms (Non-Patent Document 1), and light emitted from LED lighting and liquid crystal displays using LEDs as backlights has a significant effect on the body and mind (Non-Patent Document 1). 2) It has been reported that violet light prevents myopia and suppresses the onset of myopia (Patent Document 1). Particularly recently, the present inventors have made interesting reports about the effects of violet light on the eyes. It has been proposed that the myopia population is still increasing worldwide, and there are great expectations in recent years.
　また、各種の治療技術の研究開発も活発であり、特に薬を使用せず又はその使用を減らすことができ、身体への負荷を減らした治療技術の研究開発が行われている。 In addition, research and development of various treatment techniques is also active, and research and development of treatment techniques that do not use drugs or can reduce their use and reduce the burden on the body are being carried out.
ＷＯ２０１５／１８６７２３Ａ１WO2015/186723A1
　本発明は、発明者らが特定波長の光、特にバイオレットライト（３６０～４００ｎｍ領域の可視光線）の点滅周波数での照射が生体に様々な影響を生じさせていることを見いだし、その知見に基づいてさらに検討しで得られた成果であって、その目的は、バイオレットライト等の特定波長の光を常灯又は特定の点滅周波数で照射した光刺激による生体機能制御装置及び方法、涙液量増加促進装置及び方法、睡眠効率又は睡眠の質の改善装置及び方法、血中グルコース濃度低減又は増加抑制装置及び方法、体温低下促進装置及び方法、体重増加抑制装置及び方法、脳血流及び脳酸素濃度増加促進装置及び方法、副交感神経活性化促進装置及び方法、並びに光環境改善装置及び方法を提供することにある。 The present invention is based on the findings that the inventors have found that irradiation with light of a specific wavelength, especially violet light (visible light in the range of 360 to 400 nm), at a blinking frequency causes various effects on living organisms. It is the result obtained by further investigation, and the purpose is a biological function control device and method by optical stimulation by irradiating light of a specific wavelength such as violet light at a constant light or a specific blinking frequency, and an increase in the amount of lacrimal fluid. Apparatus and method for promotion, apparatus and method for improving sleep efficiency or quality of sleep, apparatus and method for suppressing blood glucose level reduction or increase, apparatus and method for promoting lower body temperature, apparatus and method for suppressing weight gain, cerebral blood flow and cerebral oxygen concentration An object of the present invention is to provide an increase promoting device and method, a parasympathetic nerve activation promoting device and method, and a light environment improving device and method.
　また、本発明の目的は、バイオレットライトを常灯又は特定の点滅周波数で照射して、涙液量に関連する疾患または状態の改善又は予防、睡眠効率又は睡眠の質に関連する疾患または状態の改善又は予防、血中グルコース濃度に関連する疾患または状態の改善又は予防、体温に関連する疾患または状態の改善又は予防、体重に関連する疾患または状態の改善又は予防、脳血流及び脳酸素濃度に関連する疾患または状態の改善又は予防、並びに副交感神経に関連する疾患または状態の改善又は予防のための方法又は装置を提供することにある。 Another object of the present invention is to improve or prevent a disease or condition related to tear volume, improve or prevent a disease or condition related to sleep efficiency or sleep quality by irradiating a violet light with a constant light or a specific blinking frequency. amelioration or prevention, amelioration or prevention of diseases or conditions related to blood glucose level, amelioration or prevention of diseases or conditions related to body temperature, amelioration or prevention of diseases or conditions related to body weight, cerebral blood flow and cerebral oxygen concentration The purpose of the present invention is to provide a method or device for amelioration or prevention of diseases or conditions related to the parasympathetic nervous system, and amelioration or prevention of diseases or conditions related to parasympathetic nerves.
　さらに、本発明は、バイオレットライト等の特定波長の光を常灯又は特定の点滅周波数で照射することによる、室内環境を改善する方法及び装置を提供することも目的とする。 A further object of the present invention is to provide a method and apparatus for improving the indoor environment by irradiating light of a specific wavelength such as violet light at a constant light or at a specific flickering frequency.
　本発明に係る光刺激による生体機能制御装置は、特定波長の光を常灯又は特定の点滅周波数で生体（例えば、ヒトを含む哺乳動物）に照射して生体機能制御を行う装置であって、前記特定波長の光を常灯又は特定の点滅周波数で照射する光源と、前記光を受けた前記生体の生体機能が制御される光を発光制御する制御部とを有する、ことを特徴とする。本発明に係るいくつかの実施形態では、生体機能の制御は、生体の体温の制御、体温の制御、体重の制御、血中グルコース濃度の制御、涙液量の制御、副交感神経活性化の制御、睡眠効率又は睡眠の質の制御、脳血流及び脳酸素濃度の制御に関するが、これらに限定はされない。 The apparatus for controlling biological functions by optical stimulation according to the present invention is an apparatus for controlling biological functions by irradiating a living body (for example, mammals including humans) with light of a specific wavelength at a constant light or a specific blinking frequency, The apparatus is characterized by comprising a light source that emits the light of the specific wavelength at a constant light or at a specific flickering frequency, and a controller that controls emission of the light that controls the biological function of the living body that receives the light. In some embodiments of the present invention, the control of biological function is control of body temperature, body temperature control, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control , control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation, but are not limited thereto.
　この発明によれば、光を受けた生体の生体機能が制御されるので、光の照射状態を制御することによって、生体に様々な刺激を付与することができ、又は生体の機能を高めることができる。特に生体機能に関連する疾患又は状態に影響を及ぼすことで、それに起因した様々な心身改善効果や治療効果に応用できる。 According to the present invention, since the biological functions of the living body that receives the light are controlled, various stimuli can be given to the living body or the functions of the living body can be enhanced by controlling the irradiation state of the light. can. In particular, by influencing a disease or condition related to biological functions, it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom.
　本発明に係る生体機能制御装置において、前記光は例えば、バイオレットライトである。この発明によれば、可視光領域外波長のバイオレットライトを生体に照射できるので、白色光のようなちらつきや眩しさを感じることなく、生体に影響を及ぼすことができる。なお、バイオレットライトは３６０～４００ｎｍの波長光であり、その波長光は白色光に比べて視覚感度が低く、生体（特にヒト）にとって違和感を与えない又は与えにくい波長域である。 In the biological function control device according to the present invention, the light is, for example, violet light. According to the present invention, the living body can be irradiated with violet light having a wavelength outside the visible light range, so that the living body can be affected without feeling the flicker or glare of white light. Violet light is light with a wavelength of 360 to 400 nm, which has a lower visual sensitivity than white light and is in a wavelength range that does not or hardly gives discomfort to living organisms (especially humans).
　本発明の一部の実施形態においては、３５０～４００ｎｍの範囲の波長の光、例えば、３５０ｎｍ、３６０ｎｍ、３７０ｎｍ、３８０ｎｍ、３９０ｎｍ又は４００ｎｍのいずれかの波長の光、又は上記の任意の波長により規定される範囲（例えば、３７０～３９０ｎｍの範囲）に含まれる任意の波長の光が使用されてもよい。本発明の一部の実施形態においては、波長は約３８０ｎｍを含む。なお、本明細書において用いられる「約」との語は、この語が修飾する数値の前後５％の数値を含むことを表す。 In some embodiments of the invention, light with a wavelength in the range of 350-400 nm, such as light with a wavelength of any of 350 nm, 360 nm, 370 nm, 380 nm, 390 nm or 400 nm, or any wavelength defined above Any wavelength of light that falls within the range (eg, 370-390 nm range) may be used. In some embodiments of the invention the wavelength includes about 380 nm. The term "about" used in this specification means to include 5% before and after the numerical value modified by this term.
　本発明に係る生体機能制御方法及び装置において、前記光の照射状態は、常灯（すなわち、０Ｈｚ）又は０Ｈｚ超～１５０Ｈｚの点滅周波数である。 In the biological function control method and apparatus according to the present invention, the light irradiation state is a constant light (that is, 0 Hz) or a blinking frequency of over 0 Hz to 150 Hz.
　本発明の一部の実施形態においては常灯（０Ｈｚ）の光又は、３０～７５Ｈｚの範囲の点滅周波数の光、例えば、３０Ｈｚ、３５Ｈｚ、４０Ｈｚ、４５Ｈｚ、５０Ｈｚ、５５Ｈｚ、６０Ｈｚ、６５Ｈｚ、７０Ｈｚ又は７５Ｈｚのいずれかの点滅周波数の光、又は上記の任意の点滅周波数により規定される範囲（例えば、３５～４５Ｈｚの範囲）に含まれる任意の点滅周波数の光が使用されてもよい。本発明の一部の実施形態においては、点滅周波数は約４０Ｈｚである。 In some embodiments of the present invention, constant (0 Hz) light or flashing frequency light in the range of 30-75 Hz, e.g. Light with any flash frequency of 75 Hz, or any flash frequency within the range defined by any of the above flash frequencies (eg, 35-45 Hz range) may be used. In some embodiments of the invention, the blinking frequency is approximately 40 Hz.
　本発明に係る生体機能制御装置において、前記光を、例えば、放射照度で０．５～１０００μＷ／ｃｍ２の範囲内で照射することができる。いくつかの実施形態によれば、上記放射照度の範囲内でバイオレットライト等を照射して、生体機能を任意にコントロールすることができる。特に微量の弱い光（光感度の弱い光）であっても特徴的な現象が生じうることが確認されている。 In the biological function control device according to the present invention, the light can be irradiated with an irradiance of, for example, 0.5 to 1000 μW/cm 2 . According to some embodiments, it is possible to arbitrarily control biological functions by irradiating violet light or the like within the above range of irradiance. In particular, it has been confirmed that even a very small amount of weak light (light with low photosensitivity) can cause a characteristic phenomenon.
　本発明に係る生体機能制御装置において、前記制御部は、携帯端末等の隔離コントローラーとの間の送受信により、前記光の照射状態（常灯又は点滅周波数を含む。）、放射照度、照射時間、照射開始時間、照射終了時間、常灯又は点滅周波数等の照射条件を変更して実行することができる。いくつかの実施形態によれば、上記した様々な照射条件を隔離コントロールするので、生体機能制御を生じさせるのに適した照射条件に任意に設定して、所望の効果を得ることができる。さらに、特定波長光の点滅周波数等での照射が、生体機能にどのように影響し、心身への影響等がどの程度になるかを測定評価し、実用に適用することができる。 In the biological function control device according to the present invention, the control unit controls the irradiation state of the light (including constant light or blinking frequency), irradiance, irradiation time, and the like by transmitting and receiving with an isolation controller such as a mobile terminal. It can be executed by changing irradiation conditions such as irradiation start time, irradiation end time, constant light or flashing frequency. According to some embodiments, the various irradiation conditions described above are controlled in isolation so that irradiation conditions suitable for producing biofunction control can be arbitrarily set to achieve the desired effect. Furthermore, it is possible to measure and evaluate how irradiation of light with a specific wavelength at a flickering frequency or the like affects biological functions, and to what extent the effects on the mind and body are, and apply the results to practical use.
　本発明に係る生体機能制御装置において、前記光源は、光源付きめがね（例えば、図２を参照）又はめがねフレーム、卓上光源、移動体端末装着光源等の顔前又は近傍設置型の光源でありうる。いくつかの実施形態によれば、装着が容易で日常的に違和感のない光源付きめがね又はめがねフレーム等の顔前又は近傍設置型の光源から特定の光を照射できるので、実用性が高く、様々な場面や環境でも常時照射することができる。 In the biological function control device according to the present invention, the light source may be spectacles with a light source (see, for example, FIG. 2), a spectacle frame, a desktop light source, or a light source installed near the face, such as a light source attached to a mobile terminal. . According to some embodiments, specific light can be emitted from a light source installed in front of or near the face, such as spectacles with a light source or a spectacle frame that is easy to wear and does not cause discomfort on a daily basis. You can always irradiate even in difficult scenes and environments.
　本発明に係る生体機能制御装置において、前記光源は、携帯光源等の非設置型光源、又は、室内照明、卓上スタンド、専用装置等の設置型光源としてもよい。本発明に係る生体機能制御装置は、例えば、睡眠効率又は睡眠の質の改善を誘導しうることから、例えば、ベッドサイドに置く卓上ライトや読書灯、デスク照明、壁掛照明、シーリングライトなどの形態としてもよい。いくつかの実施形態によれば、使用環境に応じた種々の光源形態の装置とすることができる。例えば、光源はバイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズと組み合わせて使用されてもよい。また、バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを通過した日光を光源として利用してもよい。 In the biological function control device according to the present invention, the light source may be a non-installed light source such as a portable light source, or an installed light source such as a room lighting, table lamp, or dedicated device. Since the biological function control device according to the present invention can induce, for example, an improvement in sleep efficiency or sleep quality, it can be used in the form of a bedside desk light, reading light, desk lighting, wall-mounted lighting, ceiling light, or the like. may be According to some embodiments, the device can have various light source forms depending on the usage environment. For example, the light source may be used in combination with glasses, spectacle lenses, or contact lenses that allow violet light to pass through. Alternatively, sunlight passing through glasses, spectacle lenses, or contact lenses that allow violet light to pass through may be used as a light source.
　本発明に係る光刺激による生体機能制御方法は、特定波長の光を常灯又は特定の点滅周波数で生体（例えば、ヒトを含む哺乳動物）に照射して生体機能制御を行う方法であって、前記光を受けた前記生体の機能が制御される光を発光制御する、ことを特徴とする。 The method for controlling biological functions by light stimulation according to the present invention is a method for controlling biological functions by irradiating a living body (for example, mammals including humans) with light of a specific wavelength at a constant light or a specific blinking frequency, It is characterized by controlling the emission of light that controls the function of the living body that receives the light.
　本発明に係る生体機能制御装置は、バイオレットライトの常灯光を生体に照射して生体機能を改善又は予防する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 A biological function control device according to the present invention is a device for improving or preventing a biological function by irradiating a living body with constant violet light, comprising: a light source emitting the violet light; and a light emission time control unit that emits light for a specific period.
　本発明の一部の実施形態においては、光を照射する特定の時間は、１日あたり１０秒～２４時間の範囲の任意の時間、例えば、１０秒、３０秒、４５秒、１分、３分、５分、１０分、１５分、３０分、４５分、１時間、２時間、３時間、４時間、５時間、６時間、７時間、８時間、９時間、１０時間、１１時間、１２時間、１８時間、２４時間のいずれかの時間、又は上記の任意の時間により規定される範囲（例えば、１～１２時間の範囲）に含まれる任意の時間でありうる。光照射を継続する特定の期間は、例えば１日、２日、３日、４日、５日、６日、１週間、２週間、３週間、１カ月、２カ月、３カ月、６カ月、１年、２年、３年、又はそれ以上の期間でありうる。 In some embodiments of the invention, the specific time of light irradiation is any time in the range of 10 seconds to 24 hours per day, such as 10 seconds, 30 seconds, 45 seconds, 1 minute, 3 minutes, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, It can be any time of 12 hours, 18 hours, 24 hours, or any time within the range defined by any of the above (eg, 1 to 12 hours). The specific period of continued light irradiation is, for example, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months, It can be for a period of 1 year, 2 years, 3 years or more.
　さらに、以下において図面を参照しつつ説明するように、本発明の一部の実施形態においては、涙液量増加促進装置及び方法、睡眠効率又は睡眠の質の改善装置及び方法、血中グルコース濃度低減又は増加抑制装置及び方法、体温低下促進装置及び方法、体重増加抑制装置及び方法、副交感神経活性化促進装置及び方法、脳血流及び脳酸素濃度増加促進装置及び方法、並びに光環境改善装置及び方法が提供される。 Furthermore, as described below with reference to the drawings, in some embodiments of the present invention, a device and method for promoting increased tear volume, a device and method for improving sleep efficiency or sleep quality, a blood glucose level, Reduction or increase suppressing device and method, body temperature reduction promoting device and method, weight gain suppressing device and method, parasympathetic nerve activation promoting device and method, cerebral blood flow and cerebral oxygen concentration increasing promoting device and method, light environment improving device and A method is provided.
脳の各部の説明図である。It is explanatory drawing of each part of a brain. バイオレットライトを照射するバイオレットライトめがねの一例である。It is an example of violet light glasses that emit violet light. 紫色蛍光灯の光の分光放射照度と波長との関係を示すグラフである。4 is a graph showing the relationship between spectral irradiance and wavelength of light from a violet fluorescent lamp. ピーク波長が３７５ｎｍのＬＥＤの光スペクトラムである。It is the optical spectrum of an LED with a peak wavelength of 375 nm. 本発明による生体機能制御装置の一形態のブロック図である。1 is a block diagram of one embodiment of a biological function control device according to the present invention; FIG. 被験者の入眠前１時間の体温変化を示すグラフである。It is a graph which shows the temperature change of a test subject 1 hour before falling asleep. 被験者の入眠前１時間の体温を示すグラフである。It is a graph which shows the body temperature of a test subject 1 hour before falling asleep. バイオレットライトを追加した又は追加していない光を照射したマウスの体温を示すグラフである。左側の棒グラフは７０週齢のマウスの体温を示している。右側の折れ線グラフは、５０週齢から７０週齢までのマウスの体温の推移を示している。FIG. 10 is a graph showing body temperature of mice illuminated with or without the addition of violet light. FIG. The bar graph on the left shows the body temperature of 70-week-old mice. The line graph on the right shows changes in body temperature of mice from 50 to 70 weeks of age. バイオレットライトを追加した又は追加していない光を照射したマウスの体重を示すグラフである。左側の棒グラフは７０週齢のマウスの体重を示している。右側の折れ線グラフは、５０週齢から７０週齢までのマウスの体重の推移を示している。Figure 10 is a graph showing body weight of mice illuminated with or without the addition of violet light. The bar graph on the left shows the body weight of 70-week-old mice. The line graph on the right shows changes in body weight of mice from 50 to 70 weeks of age. 被験者の涙液量を示すグラフである。It is a graph which shows a test subject's tear volume. バイオレットライト照射前後のＯｘｙ－Ｈｂ変化量（上段）及びバイオレットライト照射中のＯｘｙ－Ｈｂ分散（下段）を示す図である。FIG. 4 is a diagram showing Oxy-Hb variation before and after violet light irradiation (upper) and Oxy-Hb dispersion during violet light irradiation (lower). 被験者のＮ２睡眠段階（睡眠効率）（上段）、Ｎ１睡眠段階割合（下段左）及び中途覚醒割合（下段右）を示すグラフである。It is a graph which shows a test subject's N2 sleep stage (sleep efficiency) (upper stage), N1 sleep stage ratio (lower left stage), and nocturnal awakening ratio (lower right stage). 入眠８時間前からの体温変化を示すグラフである。８名の被験者の平均体温変化（Ｘ軸）と体温（Ｙ軸）が示されている。It is a graph showing changes in body temperature from 8 hours before falling asleep. Mean body temperature change (X-axis) and body temperature (Y-axis) for eight subjects are shown. 睡眠前後及び覚醒時の体温変化を示すグラフである。It is a graph showing changes in body temperature before and after sleep and during wakefulness. バイオレットライト照射による１週間を通じた血中グルコースの低下を示すグラフである。グルコース平均値の変化が示されている。Fig. 3 is a graph showing reduction in blood glucose over a week by violet light irradiation. Changes in glucose mean are shown. バイオレットライト照射による１週間を通じた血中グルコースの低下を示すグラフである。グルコース最高値の変化が示されている。Fig. 3 is a graph showing reduction in blood glucose over a week by violet light irradiation. Changes in glucose maxima are shown. 脳血流動態の平均分布を示した図である。酸素化ヘモグロビン濃度と脱酸素化ヘモグロビン濃度の変化が示されている。FIG. 4 is a diagram showing the average distribution of cerebral blood flow dynamics; Changes in oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration are shown. 図１７の測定を定量化したグラフである。酸素化ヘモグロビン濃度と酸素化ヘモグロビン濃度と脱酸素化ヘモグロビン濃度の変化が示されている。Figure 18 is a graph quantifying the measurements of Figure 17; Changes in oxygenated hemoglobin concentration, oxygenated hemoglobin concentration, and deoxygenated hemoglobin concentration are shown.
　本発明に係る光刺激による生体機能制御装置及び方法、涙液量増加促進装置及び方法、睡眠効率又は睡眠の質の改善装置及び方法、血中グルコース濃度低減又は増加抑制装置及び方法、体重増加抑制装置及び方法、脳血流及び脳酸素濃度増加促進装置及び方法、並びに光環境改善装置及び方法について図面を参照しつつ説明する。本発明は、以下の実施形態及び実施例の内容に限定されず、本発明の要旨を包含する範囲で種々の変形例や応用例を含む。 Apparatus and method for controlling biological functions by light stimulation according to the present invention, apparatus and method for promoting increase in tear volume, apparatus and method for improving sleep efficiency or quality of sleep, apparatus and method for suppressing blood glucose level reduction or increase, suppression of weight gain according to the present invention A device and method, a device and method for promoting an increase in cerebral blood flow and cerebral oxygen concentration, and a device and method for improving a light environment will be described with reference to the drawings. The present invention is not limited to the following embodiments and examples, and includes various modifications and applications within the scope of the present invention.
　［光刺激による生体機能制御装置］
　本発明に係る光刺激による生体機能制御装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して生体機能制御を行う装置であって、前記特定波長の光を常灯又は特定の点滅周波数で照射する光源と、前記光を受けた前記生体の生体機能制御を誘導する光を発光制御する制御部とを有する、ことを特徴とする。 [Biological function control device by optical stimulation]
A device for controlling biological functions by optical stimulation according to the present invention is a device for controlling biological functions by irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, wherein the light with the specific wavelength is always lit or It is characterized by comprising a light source that emits light at a specific flickering frequency, and a control unit that controls emission of light that induces control of biological functions of the living body that receives the light.
　この生体機能制御装置は、光の照射状態を制御することによって、生体に様々な刺激を付与することができる。特に生体機能に関連する疾患又は状態に影響を及ぼすことで、それに起因した様々な心身改善効果や治療効果に応用できる。本発明に係るいくつかの実施形態では、生体機能の制御は、生体の体温の制御、体重の制御、血中グルコース濃度の制御、涙液量の制御、副交感神経活性化の制御、睡眠効率又は睡眠の質の制御、脳血流及び脳酸素濃度の制御に関するが、これらに限定はされない。なお、点滅周波数等の照射状態の光の照射を用いる際には、音、振動、磁界、電場等を併せて付与することもでき、両者の複合的な作用を生じさせることができる。 This biological function control device can apply various stimuli to the living body by controlling the state of light irradiation. In particular, by influencing a disease or condition related to biological functions, it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom. In some embodiments of the present invention, the control of biological function is control of body temperature, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control, sleep efficiency or It relates to, but is not limited to, control of sleep quality, control of cerebral blood flow and cerebral oxygenation. In addition, when using irradiation of light in an irradiation state such as a flashing frequency, sound, vibration, magnetic field, electric field, etc. can be applied together, and a combined action of both can be produced.
　いくつかの実施形態において、本発明に係る生体機能制御装置は、上述のように、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して生体機能を制御する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、生体機能を制御するために使用される装置である、ことを特徴とする。 In some embodiments, the biological function control device according to the present invention is, as described above, a device for controlling a biological function by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light a light source that emits light, a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period, It is characterized in that it is a device used to control the
　また、本発明に係る生体機能制御装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して生体機能を制御する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the biological function control device according to the present invention is a device for controlling a biological function by irradiating a living body with constant violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る生体機能制御装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、光刺激による生体機能制御装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the biological function control device according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body. The present invention relates to a device for controlling biological function by light stimulation, which is light of a specific wavelength that produces a biological function controlling effect by irradiation. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　（光源）
　光源が発光する光の波長は特に限定されないが、一部の実施形態では３６０～４００ｎｍで定義されるバイオレットライトが使用される。 (light source)
The wavelength of light emitted by the light source is not particularly limited, but violet light defined as 360-400 nm is used in some embodiments.
　発振周波数は、０（常灯、直流光）～１５０Ｈｚまで可能な光源を好ましく適用できる。周波数は、制御部の設定により、０．５Ｈｚ単位や１Ｈｚ単位で調整でき、任意の点滅周波数の光を生じさせることができる。点滅周波数を増していくと、個人差はあるものの点滅が気にならなくなるという利点もある。点滅周波数は、実験例で用いた１０Ｈｚや６０Ｈｚに限定されない。 A light source whose oscillation frequency can range from 0 (ordinary light, DC light) to 150 Hz can be preferably applied. The frequency can be adjusted in units of 0.5 Hz or 1 Hz by setting the control section, and light with any flickering frequency can be generated. Increasing the blinking frequency also has the advantage that the blinking becomes less annoying, although there are individual differences. The blinking frequency is not limited to 10 Hz or 60 Hz used in the experimental examples.
　光源からの放射照度は、可変可能なものであってもよいし、一定値のものであってもよい。一部の実施形態では、最大出力３１０μＷ／ｃｍ２のものが使用されるがこれに限定されない。例えば１μＷ／ｃｍ２（０．０１Ｗ／ｍ２）～１０００μＷ／ｃｍ２（１０Ｗ／ｍ２）の範囲内のものや、例えば０．５μＷ／ｃｍ２（０．００５Ｗ／ｍ２）～５００μＷ／ｃｍ２（５Ｗ／ｍ２）の範囲内のものや、０．５～１０００μＷ／ｃｍ２の範囲内のもの等、任意に構成できる。さらに、こうした放射照度の光源であれば、めがね又はめがねフレーム、その他の携帯型照射装置にも容易に適用できるので、日常生活の中でも装着することができる。特に微量の弱い光（光感度の弱い光）であっても特徴的な現象が生じていることが確認されており、脳を含む生体の各部への影響や細胞活性（遺伝子発現制御も含む意味で用いる。）への応用が期待できる。 The irradiance from the light source may be variable or constant. In some embodiments, but not limited to, a maximum power of 310 μW/cm 2 is used. For example, in the range of 1 μW/cm 2 (0.01 W/m 2 ) to 1000 μW/cm 2 (10 W/m 2 ), or in the range of 0.5 μW/cm 2 (0.005 W/m 2 ) to 500 μW/cm 2 (5 W/m 2 ) or 0.5 to 1000 μW/cm 2 . Furthermore, a light source with such irradiance can be easily applied to spectacles or spectacle frames, or other portable illumination devices, so that they can be worn in daily life. In particular, it has been confirmed that even a very small amount of weak light (light with low photosensitivity) causes a characteristic phenomenon. ) can be expected to be applied.
　光を比視感度で特定してもよい。低い比視感度でも本発明の特徴は実現できるので、低い比視感度のもとで、生体に刺激を生じさせるバイオレットライトの点滅照射することができ、生体に負担なく所望の部位を刺激することができる。 The light may be specified by relative luminosity. Since the features of the present invention can be realized even with a low relative luminous efficiency, it is possible to irradiate a blinking violet light that causes stimulation to the living body under the low relative luminous efficiency, and to stimulate a desired part without burdening the living body. can be done.
　光の照射時間は、その目的に応じて任意に設定することが好ましく、短時間であっても長時間であってもよい。光は、任意に間欠的（一定間隔又は不定期間隔）としたり、連続的としたりすることもできる。光の照射時間は、例えば、午前８時から午後１時までの間、午前９時から１２時までの間、又は午前１０時から１１時までの間の時間帯に設定することができ、期間は少なくとも１０分、少なくとも１５分、少なくとも２０分、少なくとも３０分、少なくとも１時間、少なくとも２時間、少なくとも３時間、少なくとも４時間、または５時間とすることができる。いくつかの実施形態では、午前９時から１２時までの間、３時間の照射、または午前９時から１１時までの間、２時間の照射が適用される。このように時間を設定した照射の際にはタイマー機能を用いることができる。 The light irradiation time is preferably set arbitrarily according to the purpose, and may be short or long. The light can optionally be intermittent (regular or irregular) or continuous. The light irradiation time can be set, for example, between 8:00 am and 1:00 pm, between 9:00 am and 12:00 am, or between 10:00 am and 11:00 am. can be at least 10 minutes, at least 15 minutes, at least 20 minutes, at least 30 minutes, at least 1 hour, at least 2 hours, at least 3 hours, at least 4 hours, or 5 hours. In some embodiments, 3 hours of irradiation between 9:00 am and 12:00 am or 2 hours of irradiation between 9:00 am and 11:00 am is applied. A timer function can be used for such irradiation with a set time.
　光源は、光源付きめがね又はめがねフレームでありうる。そうしためがね又はめがねフレームは、装着が容易で日常的に違和感のないめがね又はめがねフレームに点滅周波数を発する光源を取り付けているので、実用性が高く、様々な場面や環境でも常時装着することができる。また、光源は、卓上光源、移動体端末装着光源等の顔前又は近傍設置型の光源であってもよいし、携帯光源等の非設置型光源、又は、室内照明、卓上スタンド、専用装置等の設置型光源であってもよく、使用環境に応じた種々の光源形態の装置とすることができる。 The light source can be spectacles with a light source or a spectacle frame. Such spectacles or spectacle frames are easy to wear and have a light source that emits a blinking frequency attached to the spectacles or spectacle frames that do not cause discomfort on a daily basis. . In addition, the light source may be a light source installed in front of or near the face, such as a desk light source or a light source attached to a mobile terminal, or a non-installed light source such as a portable light source, or an indoor lighting, a desk stand, a dedicated device, or the like. The light source may be an installation type light source, and the device may have various light source forms according to the usage environment.
　（制御部）
　制御部は、光源からの光の照射状態（常灯や点滅周波数）をコントロールする部分である。制御部は、光源に電力を供給するための電源を備えたものであってもよく、そうした電源はバッテリーであってもよいし、別の位置に装着したバッテリーまでケーブルで引き回したものであってもよい。また、一箇所で動かない場合には、家庭用電源等に接続する形態であってもよい。 (control part)
The control unit is a part that controls the irradiation state of light from the light source (normal light or flashing frequency). The controller may include a power source for powering the light source, such power source may be a battery or routed by cable to a battery mounted in another location. good too. Moreover, when it does not move in one place, the form connected to a household power supply etc. may be sufficient.
　制御部は、携帯端末等の隔離コントローラーとの間の送受信により、光の点滅周波数、放射照度、照射時間、照射開始時間、照射終了時間、点滅周波数等の照射条件の変更を実行するものであることが好ましい。こうした制御部は、上記した様々な照射条件を隔離コントロールするので、所望の生体機能制御を生じさせるのに適した照射条件に任意に設定して、所望の効果を得ることができる。さらに、特定波長光の点滅周波数での照射が、生体機能にどのように影響し、心身への影響がどの程度になるかを測定評価し、実用に適用することができる。 The control unit changes the irradiation conditions such as the blinking frequency of the light, the irradiance, the irradiation time, the irradiation start time, the irradiation end time, the blinking frequency, etc. is preferred. Since such a control unit isolates and controls the various irradiation conditions described above, it is possible to arbitrarily set irradiation conditions suitable for producing desired biological function control and obtain desired effects. Furthermore, it is possible to measure and evaluate how irradiation of light with a specific wavelength at the flickering frequency affects biological functions and the extent of the effect on the mind and body, and apply this to practical use.
　さらに、制御部は、光源のコントローラーやタイマー機能を備えていてもよい。コントローラーは、周波数や放射照度を可変したり、照射時間を設定したりする機能等を挙げることができる。また、タイマー機能は、光の放射照度時間を設定できるものを挙げることができる。こうしたコントローラーやタイマー機能は、器具と一体として設けられていてもよいし、別部材としてもよい。 Furthermore, the control unit may have a light source controller and a timer function. The controller can include functions such as changing the frequency and irradiance and setting the irradiation time. Moreover, the timer function can be exemplified by one that can set the irradiance time of light. Such a controller and timer function may be provided integrally with the instrument, or may be provided as separate members.
　本発明に係る装置の１つの形態として、上述した生体機能制御等に用いることができる装置の単純化された一例のブロック図を図５に示す。図５に示す装置は、本明細書で説明した生体機能制御装置、及び涙液量増加促進装置、睡眠効率又は睡眠の質の改善装置、血中グルコース濃度低減又は増加抑制装置、体温低下促進装置、体重増加抑制装置、副交感神経活性化装置、脳血流及び脳酸素濃度増加促進装置、並びに光環境改善装置（これらを総称して単に「生体機能制御装置」ということができる）の持つ各種機能を含み得るものであり、したがって、本明細書において上述した全て装置は、図５のブロック図で表すことができる。生体機能制御装置は、光源１０と制御部２０とを有することができる。光源１０は、特定波長の光を照射する。光源１０が照射する光の波長は、これまで述べてきたＶＬまたは３５０～４００ｎｍを含むことが好ましく、より好ましくは３８０ｎｍを含む。光源１０は任意の光源であってよく、小型、長寿命、かつ点滅制御の容易さ等の観点から発光ダイオード（ＬＥＤ）を好ましく用いることができる（紫色蛍光灯のスペクトルの例は図３、ＬＥＤのスペクトルの例は図４を参照）。光源１０の数は、目的とする光源の照射強度および照射範囲等に応じて１つであってもよいし複数であってもよい。 As one form of the device according to the present invention, FIG. 5 shows a simplified block diagram of an example of the device that can be used for the above-described biological function control. The device shown in FIG. 5 includes the biological function control device described herein, a tear volume increase promotion device, a sleep efficiency or sleep quality improvement device, a blood glucose level reduction or increase suppression device, and a body temperature reduction promotion device. , weight gain suppression device, parasympathetic nerve activation device, cerebral blood flow and cerebral oxygen concentration increase promotion device, and light environment improvement device (these can be collectively referred to simply as “biological function control device”). , and thus all the devices described herein above can be represented by the block diagram of FIG. The biological function control device can have a light source 10 and a controller 20 . The light source 10 emits light of a specific wavelength. The wavelength of the light emitted by the light source 10 preferably includes VL or 350 to 400 nm, and more preferably includes 380 nm. The light source 10 may be any light source, and a light emitting diode (LED) can be preferably used from the viewpoint of small size, long life, and ease of blinking control (an example of the spectrum of a violet fluorescent lamp is shown in FIG. 3, LED (see Figure 4 for an example of the spectrum of ). The number of light sources 10 may be one or more depending on the target irradiation intensity and irradiation range of the light sources.
　制御部２０は、光源１０と有線接続または無線接続され、光源１０の照射条件を制御するように構成される。照射条件は、光源１０の点滅周波数および照射時間の少なくとも１つを含むことができ、したがって、制御部２０は、点滅周波数制御部２０ａおよび照射時間制御部２０ｂの少なくとも１つを含むことができる。点滅周波数は、好ましくは０Ｈｚ又は３０～７５Ｈｚ、より好ましくは０Ｈｚ又は３５～４５Ｈｚ、特に好ましくは０Ｈｚ又は４０Ｈｚであってよい。なお、点滅周波数が０Ｈｚとは、常灯を意味する。照射時間は、例えば、１日あたり１０秒～２４時間の範囲で任意に定めることができ、照射を継続する特定の期間も、例えば１日から数年、又はそれ以上と任意に定めることができる。 The control unit 20 is wired or wirelessly connected to the light source 10 and configured to control the irradiation conditions of the light source 10 . The irradiation conditions can include at least one of the blinking frequency and the irradiation time of the light source 10, and therefore the control unit 20 can include at least one of the blinking frequency control unit 20a and the irradiation time control unit 20b. The blinking frequency may preferably be 0 Hz or 30-75 Hz, more preferably 0 Hz or 35-45 Hz, particularly preferably 0 Hz or 40 Hz. Note that the flashing frequency of 0 Hz means a constant light. The irradiation time can be arbitrarily determined, for example, in the range of 10 seconds to 24 hours per day, and the specific period of continuation of irradiation can also be arbitrarily determined, for example, from one day to several years or longer. .
　制御部２０は、ＣＰＵ（Ｃｅｎｔｒａｌ　Ｐｒｏｃｅｓｓｉｎｇ　Ｕｎｉｔ）等のプロセッサを含むことができ、光源１０の照射条件を制御する処理を実行する。制御部２０で行なわれる処理は、コンピュータプログラムで実現してもよいし、論理回路によるハードウェアで実現してもよい。コンピュータプログラムは、コンピュータ読み取り可能な記録媒体に記憶させてもよい。コンピュータプログラムを記憶した記録媒体は、非一過性の記録媒体であってもよい。非一過性の記録媒体は特に限定されず、例えば、メモリーカード、ＣＤ－ＲＯＭ等の記録媒体であってもよい。記録媒体に記憶されたコンピュータプログラムは、適宜のリーダーを介してコンピュータユニットに実装することができる。適宜のリーダーとは、例えば、記録媒体がメモリーカードである場合はカードリーダ、記録媒体がＣＤ－ＲＯＭである場合はＣＤドライブ、などが挙げられる。または、コンピュータプログラムは、外部のサーバから通信ネットワークを介してコンピュータユニットにダウンロードされたものであってもよい。 The control unit 20 can include a processor such as a CPU (Central Processing Unit) and executes processing for controlling the irradiation conditions of the light source 10 . The processing performed by the control unit 20 may be implemented by a computer program or by hardware based on logic circuits. The computer program may be stored on a computer-readable recording medium. A recording medium storing a computer program may be a non-transitory recording medium. The non-transitory recording medium is not particularly limited, and may be, for example, a memory card, CD-ROM, or other recording medium. A computer program stored in a recording medium can be implemented in a computer unit via an appropriate reader. Appropriate readers include, for example, a card reader when the recording medium is a memory card, and a CD drive when the recording medium is a CD-ROM. Alternatively, the computer program may be downloaded from an external server to the computer unit via a communication network.
　図５に示した生体機能制御装置の光源１０は、光源付きめがね又はめがねフレーム、卓上光源、移動体端末装着光源、顔前または近傍設置型光源、携帯光源、室内照明、または卓上スタンドであってよい。また、生体機能制御装置は、光源１０および制御部２０のうち少なくとも光源１０が装着された、めがね又はめがねフレーム、卓上ライト、移動体端末、移動体端末用ケース、頭部装着用品（帽子、イヤホンヘッドホンなど）、携帯型ライト、室内照明、または卓上スタンドを含む光源付き製品として提供されてもよい。 The light source 10 of the biological function control device shown in FIG. good. In addition, the biological function control device includes glasses or a glasses frame on which at least the light source 10 out of the light source 10 and the control unit 20 is attached, a desk light, a mobile terminal, a mobile terminal case, head-mounted items (caps, earphones, etc.) headphones, etc.), portable lights, room lights, or lighted products, including table lamps.
　以上説明したように、本発明に係る光刺激による生体機能制御装置は、バイオレットライト等の特定波長の光を生体に常灯又は特定の点滅周波数で照射して、生体機能を制御することができる。特に生体機能に関連する疾患又は状態に影響を及ぼすことで、それに起因した様々な心身改善効果や治療効果に応用できる。 INDUSTRIAL APPLICABILITY As described above, the apparatus for controlling biological functions by optical stimulation according to the present invention can control biological functions by irradiating a living body with light of a specific wavelength such as violet light at a constant light or a specific flickering frequency. . In particular, by influencing a disease or condition related to biological functions, it can be applied to various mental and physical improving effects and therapeutic effects resulting therefrom.
　また、本発明の一つの側面は、光刺激による生体機能制御装置の作動方法に関する。よって、本発明の一部の実施形態は、生体機能の制御に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating a biological function control device using optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in controlling a biological function, the device comprising a light source that irradiates a living body with light of a specific wavelength at constant or a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　本発明に係るコンピュータプログラムは、命令が非一時的（ｎｏｎ－ｔｒａｎｓｉｔｏｒｙ）なコンピュータ可読媒体に格納されていてもよい。本開示に係るコンピュータプログラムは、命令がプロセッサによって実行されると、所定のステップを実行することができる。よって、本開示の１つの側面は、命令が格納された非一時的（ｎｏｎ－ｔｒａｎｓｉｔｏｒｙ）なコンピュータ可読媒体であって、命令がプロセッサによって実行されると、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備える装置に対して、前記制御部が、前記光源の点滅周波数を０Ｈｚ又は３０～７５Ｈｚの範囲において制御するように前記装置を作動させるステップ、並びに前記光源が、３５０～４００ｎｍの範囲の波長の光を生体に照射するように前記装置を作動させるステップを実行することができる、コンピュータ可読媒体にも関する。 The computer program according to the present invention may be stored in a non-transitory computer-readable medium. A computer program according to the present disclosure is capable of performing predetermined steps when instructions are executed by a processor. Accordingly, one aspect of the present disclosure is a non-transitory computer-readable medium having instructions stored thereon that, when executed by a processor, emit light of a particular wavelength at all times or at a particular wavelength. A device comprising a light source that irradiates a living body with a flickering frequency and a control unit that controls the flickering frequency of the light source, wherein the control unit controls the flickering frequency of the light source in the range of 0 Hz or 30 to 75 Hz. and operating the device such that the light source irradiates a living body with light in the wavelength range of 350-400 nm.
　さらに、本発明の一つの側面は、光刺激による生体機能の制御方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して生体機能を制御する方法であって、前記光を受けた前記生体において生体機能が制御される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において生体機能を制御するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において生体機能が制御される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for controlling biological functions by optical stimulation. Therefore, some embodiments of the present invention provide a method of controlling a biological function by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, wherein the biological function in the living body receiving the light is is controlled. More specifically, some embodiments of the present invention are a method for controlling a biological function in a subject in need of treatment, comprising directing light of a particular wavelength to the subject at steady on or at a particular blinking rate. A method comprising irradiating a living body with a frequency, whereby a biological function is controlled in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. .
　［涙液量増加促進装置及び方法］
　本発明者らは、さらにバイオレットライトによる涙液量への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、涙液量の増加を促進、又は低減を抑制できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る涙液量増加促進方法及び装置を完成するに至った。 [Tear volume increase promotion device and method]
The present inventors further investigated the effect of violet light on tear volume. As a result, it was found that the increase in the amount of tear fluid can be promoted or the decrease can be suppressed by light stimulation by irradiation with violet light. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors completed the method and device for promoting increased tear volume according to the present invention.
　いくつかの実施形態において、本発明に係る涙液量増加促進装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して涙液量の増加を促進又は低減を抑制する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、涙液量増加促進、又は低減抑制のために使用される装置である、ことを特徴とする。 In some embodiments, the tear volume increase promoting device according to the present invention is a device that irradiates a living body with violet light at a constant light or at a specific flickering frequency to promote an increase in tear volume or suppress a decrease in tear volume. a light source that emits the violet light, a light emission cycle control unit that sets the violet light to a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period. It is a device used for promoting an increase in the amount of tear fluid or suppressing a decrease in the tear fluid volume.
　また、本発明に係る涙液量増加促進装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して涙液量の増加を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the apparatus for promoting tear volume increase according to the present invention is an apparatus for promoting an increase in tear volume by irradiating a living body with normal light of violet light, wherein the violet light emits light. and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る涙液量増加促進装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって涙液量増加促進効果を生じさせる特定波長の光である、光刺激による涙液量増加促進装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the tear volume increase promoting device according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is The present invention relates to an apparatus for promoting tear volume increase by photo-stimulation, which is light of a specific wavelength that produces an effect of promoting tear volume increase by irradiating a living body. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による涙液量増加促進装置の作動方法に関する。よって、本発明の一部の実施形態は、涙液量増加の促進に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating an apparatus for promoting tear volume increase by optical stimulation. Thus, some embodiments of the present invention are a method of operating a device for use in promoting tear volume augmentation, wherein the device irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による涙液量増加促進方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して涙液量の増加を促進する方法であって、前記光を受けた前記生体において涙液量の増加が促進される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において涙液量の増加を促進するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において涙液量の増加が促進される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for promoting tear volume increase by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to promote an increase in tear volume, A method characterized in that an increase in tear volume is promoted in More specifically, some embodiments of the present invention are a method for promoting increased tear volume in a subject in need of treatment comprising directing a specific wavelength of light to the subject at constant or A method comprising irradiating a living body with a particular flickering frequency, thereby promoting an increase in tear volume in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、涙液量の増加は、ドライアイや涙液量の低下に伴う角膜性疾患の防止と治療効果が期待されることから、本発明の一つの側面は、角膜性疾患の予防又は治療効果を生じさせる特定波長の光を生体へ照射するように構成された角膜性疾患の予防又は治療装置及びその作動方法、又は角膜性疾患の予防又は治療効果を生じさせる特定波長の光を生体へ照射する段階を含む角膜性疾患の予防又は治療方法にも関する。より具体的には、いくつかの実施形態は、効果を生じさせる特定波長の光を生体へ照射するように構成されたドライアイの予防又は治療用装置及びその作動方法、又はドライアイの予防又は治療効果を生じさせる特定波長の光を生体へ照射する段階を含むドライアイの予防又は治療方法に関する。このような装置又は方法は、ドライアイ又は角結膜上皮障害の治療薬（ヒアルロン酸ナトリウム、ジクアホソルナトリウムなど）と組み合わせて使用されてもよい。 In addition, an increase in tear volume is expected to have a preventive and therapeutic effect on dry eye and corneal diseases associated with a decrease in tear volume. A preventive or therapeutic device for corneal diseases configured to irradiate a living body with light of a specific wavelength that produces It also relates to a method of preventing or treating corneal disease comprising the step of More specifically, some embodiments provide a dry eye prophylaxis or treatment device and method of operation configured to irradiate a living body with light of a specific wavelength that produces an effect, or dry eye prophylaxis or treatment. The present invention relates to a method for preventing or treating dry eye, including the step of irradiating a living body with light of a specific wavelength that produces a therapeutic effect. Such devices or methods may be used in combination with therapeutic agents for dry eye or keratoconjunctival epithelial disorders (sodium hyaluronate, diquafosol sodium, etc.).
　［睡眠効率又は睡眠の質の改善装置及び方法］
　本発明者らは、さらにバイオレットライトによる睡眠効率又は睡眠の質への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、睡眠効率又は睡眠の質を改善できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る睡眠効率又は睡眠の質の改善方法及び装置を完成するに至った。 [Device and method for improving sleep efficiency or sleep quality]
The present inventors further studied the effect of violet light on sleep efficiency or sleep quality. As a result, it was found that light stimulation by irradiation with violet light can improve sleep efficiency or sleep quality. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors completed the method and device for improving sleep efficiency or sleep quality according to the present invention.
　いくつかの実施形態において、本発明に係る睡眠効率又は睡眠の質の改善装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して睡眠効率又は睡眠の質を改善する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、睡眠効率又は睡眠の質の改善のために使用される装置である、ことを特徴とする。 In some embodiments, the device for improving sleep efficiency or sleep quality according to the present invention is a device for improving sleep efficiency or sleep quality by irradiating a living body with violet light at a constant light or at a specific flickering frequency. a light source that emits the violet light, a light emission cycle control unit that sets the violet light to a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period. and is a device used for improving sleep efficiency or quality of sleep.
　また、本発明に係る睡眠効率又は睡眠の質の改善装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して睡眠効率又は睡眠の質を改善する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the sleep efficiency or sleep quality improvement device according to the present invention is a device for improving sleep efficiency or sleep quality by irradiating a living body with constant violet light, It is characterized by comprising a light source that emits violet light, and a light emission time control section that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る睡眠効率又は睡眠の質の改善装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって睡眠効率又は睡眠の質の改善効果を生じさせる特定波長の光である、光刺激による睡眠効率又は睡眠の質の改善装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the sleep efficiency or sleep quality improvement device according to the present invention also includes at least one light source that emits light, and a driving circuit that drives the light source, and the light source emits The light is light of a specific wavelength that produces an effect of improving sleep efficiency or sleep quality by irradiating the living body. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による睡眠効率又は睡眠の質の改善装置の作動方法に関する。よって、本発明の一部の実施形態は、睡眠効率又は睡眠の質の改善に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method of operating a device for improving sleep efficiency or sleep quality by light stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in improving sleep efficiency or quality, wherein the device emits light of a specific wavelength to the body at a constant or a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による睡眠効率又は睡眠の質の改善方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して睡眠効率又は睡眠の質を改善する方法であって、前記光を受けた前記生体において睡眠効率又は睡眠の質が改善される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において睡眠効率又は睡眠の質を改善するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において睡眠効率又は睡眠の質が改善される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for improving sleep efficiency or sleep quality by light stimulation. Therefore, some embodiments of the present invention provide a method for improving sleep efficiency or sleep quality by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, A method characterized in that sleep efficiency or sleep quality is improved in vivo. More specifically, some embodiments of the present invention provide a method for improving sleep efficiency or sleep quality in a subject in need of treatment comprising exposing the subject to constant light of a particular wavelength. or irradiating a living body with a particular flickering frequency, whereby sleep efficiency or sleep quality is improved in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、バイオレットライトの照射が睡眠深度と質を向上させ、睡眠障害やそれに関する疾患を予防、治療できることから、本発明の一つの側面は、睡眠障害やそれに関する疾患の予防又は治療効果を生じさせる特定波長の光を生体へ照射するように構成された睡眠障害やそれに関する疾患の予防又は治療用装置及びその作動方法、又は睡眠障害やそれに関する疾患の予防又は治療効果を生じさせる特定波長の光を生体へ照射する段階を含む睡眠障害やそれに関する疾患の予防又は治療方法にも関する。より具体的には、いくつかの実施形態は、睡眠障害の予防又は治療効果を生じさせる特定波長の光を生体へ照射するように構成された睡眠障害の予防又は治療用装置及びその作動方法、又は睡眠障害の予防又は治療効果を生じさせる特定波長の光を生体へ照射する段階を含む睡眠障害の予防又は治療方法に関する。このような装置又は方法は、睡眠薬（ベンゾジアゼピン系薬、ブロチゾラム、エスタゾラム、クアゼパムなど）と組み合わせて使用されてもよい。さらに、いくつかの実施形態は、ジェットラグなどの時差ぼけの解消効果を生じさせる特定波長の光を生体へ照射するように構成された時差ぼけ解消用装置及びその作動方法、又は時差ぼけ解消効果を生じさせる特定波長の光を生体へ照射する段階を含む時差ぼけの解消方法に関する。また、いくつかの実施形態は、ナイトシフトなどの夜中に仕事をする人などが逆に早く眠れるようにする、睡眠導入効果を生じさせる特定波長の光を生体へ照射するように構成された睡眠導入装置及びその作動方法、又は睡眠導入効果を生じさせる特定波長の光を生体へ照射する段階を含む睡眠導入方法に関する。また逆に、いくつかの実施形態は、ナイトシフトなどの夜中に仕事をする人が眠らないようにする、眠気抑制効果を生じさせる特定波長の光を生体へ照射するように構成された眠気抑制装置及びその作動方法、又は眠気抑制効果を生じさせる特定波長の光を生体へ照射する段階を含む眠気抑制方法にも関する。 In addition, irradiation of violet light improves the depth and quality of sleep, and can prevent and treat sleep disorders and related diseases. Therefore, one aspect of the present invention is to produce an effect of preventing or treating sleep disorders and related diseases. Devices for preventing or treating sleep disorders and diseases related thereto, configured to irradiate a living body with light of specific wavelengths, and operating methods thereof, or lights of specific wavelengths that produce preventive or therapeutic effects for sleep disorders and diseases related thereto It also relates to a method for preventing or treating sleep disorders and related diseases, including the step of irradiating the living body with More specifically, some embodiments are a sleep disorder preventive or therapeutic device configured to irradiate a living body with light of a specific wavelength that produces a sleep disorder preventive or therapeutic effect, and a method of operating the same. Alternatively, the present invention relates to a method for preventing or treating sleep disorders, which includes the step of irradiating a living body with light of a specific wavelength that produces sleep disorder preventive or therapeutic effects. Such devices or methods may be used in combination with hypnotics (benzodiazepines, brotizolam, estazolam, quazepam, etc.). Furthermore, some embodiments are directed to a device for eliminating jet lag configured to irradiate a living body with light of a specific wavelength that produces an effect of eliminating jet lag such as jet lag, and a method of operating the same, or an effect of eliminating jet lag. It relates to a method for eliminating jet lag, which includes the step of irradiating a living body with light of a specific wavelength that causes In addition, some embodiments are configured to irradiate the living body with light of a specific wavelength that produces a sleep-inducing effect, such as a night shift, which allows people who work at night to fall asleep earlier. The present invention relates to an inducing device and its operating method, or to a sleep inducing method including the step of irradiating a living body with light of a specific wavelength that produces a sleep inducing effect. Conversely, some embodiments also include a drowsiness suppressor configured to irradiate a living body with light of a specific wavelength that produces a drowsiness suppressing effect that prevents a person working at night, such as a night shift, from falling asleep. It also relates to a device and a method of operating the same, or a drowsiness-suppressing method comprising irradiating a living body with light of a specific wavelength that produces a drowsiness-suppressing effect.
　［血中グルコース濃度低減又は増加抑制装置及び方法］
　本発明者らは、さらにバイオレットライトによる血中グルコース濃度への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、血中グルコース濃度を低減又は増加抑制できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る血中グルコース濃度の低減又は増加抑制方法及び装置を完成するに至った。 [Device and method for reducing or increasing blood glucose concentration]
The present inventors further studied the effect of violet light on blood glucose levels. As a result, it was found that the blood glucose level could be reduced or increased by the photostimulation by irradiation with violet light. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors have completed the method and apparatus for reducing or increasing the blood glucose level according to the present invention.
　いくつかの実施形態において、本発明に係る血中グルコース濃度の低減又は増加抑制装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して血中グルコース濃度を低減又は増加抑制する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、血中グルコース濃度の低減又は増加抑制のために使用される装置である、ことを特徴とする。 In some embodiments, the blood glucose level reduction or increase suppression device according to the present invention is a device for reducing or increasing blood glucose level by irradiating a living body with violet light at a constant light or at a specific flickering frequency. a light source that emits the violet light, a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period. , and is used for reducing or suppressing an increase in blood glucose concentration.
　また、本発明に係る血中グルコース濃度の低減又は増加抑制装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して血中グルコース濃度を低減又は増加抑制する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 In some embodiments, the blood glucose level reduction or increase suppression device according to the present invention is a device for reducing or increasing the blood glucose level by irradiating a living body with constant violet light. and a light source for emitting the violet light, and a light emission time control section for emitting the violet light for a specific time or for a specific period.
　また、本発明に係る血中グルコース濃度の低減又は増加抑制装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって血中グルコース濃度の低減又は増加抑制効果を生じさせる特定波長の光である、光刺激による血中グルコース濃度低減又は増加抑制装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the blood glucose level reduction or increase suppression device according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light source is The emitted light is light of a specific wavelength that produces an effect of reducing or increasing the blood glucose concentration by irradiating the living body. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による血中グルコース濃度の低減又は増加抑制装置の作動方法に関する。よって、本発明の一部の実施形態は、睡眠効率又は睡眠の質の改善に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method of operating a device for reducing or increasing blood glucose concentration by light stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in improving sleep efficiency or quality, wherein the device emits light of a specific wavelength to the body at a constant or a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による血中グルコース濃度の低減又は増加抑制方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して血中グルコース濃度を低減又は増加抑制する方法であって、前記光を受けた前記生体において血中グルコース濃度が低減又は増加抑制される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において血中グルコース濃度を低減又は増加抑制するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において血中グルコース濃度が低減又は増加抑制される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for reducing or suppressing an increase in blood glucose concentration by light stimulation. Therefore, some embodiments of the present invention provide a method for reducing or suppressing an increase in blood glucose level by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, wherein It relates to a method, characterized in that the blood glucose level is reduced or inhibited from increasing in said living body. More specifically, some embodiments of the present invention are methods for reducing or inhibiting increases in blood glucose levels in a subject in need of treatment, comprising constantly exposing the subject to a specific wavelength of light. A method comprising irradiating a living body with a light or a particular flickering frequency, whereby blood glucose levels are reduced or increased in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、血糖値の抑制を介した糖尿病の予防効果が考えられることから、本発明の一つの側面は、糖尿病の予防効果を生じさせる特定波長の光を生体へ照射するように構成された糖尿病予防装置及びその作動方法、又は糖尿病の予防効果を生じさせる特定波長の光を生体へ照射する段階を含む糖尿病予防方法にも関する。より具体的には、いくつかの実施形態は、糖尿病予防効果を生じさせる特定波長の光を生体へ照射するように構成された糖尿病予防装置及びその作動方法、又は糖尿病予防効果を生じさせる特定波長の光を生体へ照射する段階を含む糖尿病予防方法に関する。このような装置又は方法は、血糖値を下げる薬（インスリン、ピグアナイド薬、スルホニル尿素薬、チアゾリジン系薬、ＤＰＰ－４阻害薬など）又は食品（サプリメント）と組み合わせて使用されてもよい。さらに、いくつかの実施形態は、慢性腎障害、動脈硬化、脳梗塞、痛風の予防効果を生じさせる特定波長の光を生体へ照射するように構成された慢性腎障害、動脈硬化、脳梗塞、痛風の予防装置及びその作動方法、又は慢性腎障害、動脈硬化、脳梗塞、痛風の予防効果を生じさせる特定波長の光を生体へ照射する段階を含む慢性腎障害、動脈硬化、脳梗塞、痛風の予防方法に関する。このような装置又は方法は、スタチン（ＨＭＧ－ＣｏＡ還元酵素阻害薬）、フィブラート系薬剤、ニコチン酸誘導体、プロブコール、イコサペント酸エチル（ＥＰＡ）、フェブキソスタット、アロプリノール、アンジオテンシン変換酵素阻害薬、アンジオテンシン受容体拮抗薬、利尿薬、ステロイドなどの薬剤と組み合わせて使用されてもよい。 In addition, since the preventive effect of diabetes is considered to be mediated by the suppression of blood sugar level, one aspect of the present invention is a diabetes preventive that is configured to irradiate a living body with light of a specific wavelength that produces the preventive effect of diabetes. The present invention also relates to a device and method of operation thereof, or a method of preventing diabetes comprising the step of irradiating a living body with light of a specific wavelength that produces a preventive effect against diabetes. More specifically, some embodiments are a diabetes prevention device configured to irradiate a living body with light of a specific wavelength that produces a diabetes prevention effect and a method of operating the same, or a specific wavelength that produces a diabetes prevention effect It relates to a diabetes prevention method including the step of irradiating a living body with light of Such devices or methods may be used in combination with blood sugar lowering drugs (insulin, pigguanides, sulfonylureas, thiazolidines, DPP-4 inhibitors, etc.) or foods (supplements). Furthermore, some embodiments are configured to irradiate a living body with light of a specific wavelength that produces a preventive effect for chronic renal disorder, arteriosclerosis, cerebral infarction, and gout. Gout preventive device and its operation method, or chronic renal disorder, arteriosclerosis, cerebral infarction, chronic renal disorder, arteriosclerosis, cerebral infarction, gout including the step of irradiating a living body with light of a specific wavelength that produces a preventive effect for chronic renal disorder, arteriosclerosis, cerebral infarction, gout concerning the preventive method of Such devices or methods include statins (HMG-CoA reductase inhibitors), fibrates, nicotinic acid derivatives, probucol, ethyl icosapentate (EPA), febuxostat, allopurinol, angiotensin converting enzyme inhibitors, angiotensin receptors. It may be used in combination with drugs such as body antagonists, diuretics, steroids, and the like.
　［体温低下促進装置及び方法］
　本発明者らは、さらにバイオレットライトによる体温への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、体温低下を促進できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る体温低下促進方法及び装置を完成するに至った。 [Body temperature reduction acceleration device and method]
The present inventors further conducted research on the effect of violet light on body temperature. As a result, it was found that the photo-stimulation caused by the irradiation of violet light could accelerate the decrease in body temperature. Then, based on the knowledge of such effects of light stimulation by violet light, the inventors have completed the method and apparatus for promoting a decrease in body temperature according to the present invention.
　いくつかの実施形態において、本発明に係る体温低下促進装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して体温の低下を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、体温低下促進のために使用される装置である、ことを特徴とする。 In some embodiments, the device for promoting body temperature reduction according to the present invention is a device for promoting body temperature reduction by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light is emitted. a light source, a light emission cycle control unit that makes the violet light a constant light or a specific flickering frequency, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period, to promote a decrease in body temperature It is characterized by being a device used.
　また、本発明に係る体温低下促進装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して体温低下を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 In some embodiments, the device for promoting body temperature reduction according to the present invention is a device for promoting body temperature reduction by irradiating a living body with normal violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る体温低下促進装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって体温低下の促進効果を生じさせる特定波長の光である、光刺激による体温低下促進装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the device for promoting body temperature reduction according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body. The present invention relates to a device for promoting body temperature reduction by photo-stimulation, which is light of a specific wavelength that produces an effect of promoting body temperature reduction by irradiation. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による体温低下促進装置の作動方法に関する。よって、本発明の一部の実施形態は、体温の低下促進に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating a device for promoting body temperature reduction by optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in promoting hypothermia, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による体温低下促進方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して体温低下を促進する方法であって、前記光を受けた前記生体において体温低下が促進される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において体温低下を促進するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において体温低下が促進される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for promoting a decrease in body temperature by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to accelerate body temperature reduction, is promoted. More specifically, some embodiments of the present invention provide a method for promoting hypothermia in a subject in need of treatment comprising directing a constant or a particular blinking light of a particular wavelength to the subject. A method comprising irradiating a living body with a frequency, whereby hypothermia is promoted in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、体温の抑制を介した肥満の防止、老化関連疾患の予防効果が考えられることから、本発明の一つの側面は、老化関連疾患の予防効果を生じさせる特定波長の光を生体へ照射するように構成された老化関連疾患予防装置及びその作動方法、又は老化関連疾患の予防効果を生じさせる特定波長の光を生体へ照射する段階を含む老化関連疾患予防方法にも関する。より具体的には、いくつかの実施形態は、肥満防止効果を生じさせる特定波長の光を生体へ照射するように構成された肥満防止装置及びその作動方法、又は肥満防止効果を生じさせる特定波長の光を生体へ照射する段階を含む肥満防止方法に関する。このような装置又は方法は、抗肥満薬（マジンドール、オルリスタットなど）又はダイエット用食品（サプリメント）と組み合わせて使用されてもよい。 In addition, since it is possible to prevent obesity and prevent aging-related diseases through the suppression of body temperature, one aspect of the present invention is to irradiate a living body with light of a specific wavelength that produces a preventive effect on aging-related diseases. The present invention also relates to an aging-related disease preventive device configured as described above and an operation method thereof, or an aging-related disease preventive method including a step of irradiating a living body with light of a specific wavelength that produces an aging-related disease preventive effect. More specifically, some embodiments are directed to an anti-obesity device configured to irradiate a living body with light of a specific wavelength that produces an anti-obesity effect and a method of operating the same, or a specific wavelength that produces an anti-obesity effect It relates to a method for preventing obesity, which includes the step of irradiating a living body with light of Such devices or methods may be used in combination with anti-obesity drugs (Mazindol, Orlistat, etc.) or diet foods (supplements).
　［体重増加抑制装置及び方法］
　本発明者らは、さらにバイオレットライトによる体重への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、体重増加抑制を促進できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る体重増加抑制方法及び装置を完成するに至った。 [Weight gain suppression device and method]
The present inventors further conducted research on the effects of violet light on body weight. As a result, it was found that light stimulation by irradiation with violet light could promote suppression of weight gain. Then, based on the knowledge of such effects of light stimulation with violet light, the inventors completed the method and apparatus for suppressing weight gain according to the present invention.
　いくつかの実施形態において、本発明に係る体重増加抑制装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して体重の増加を抑制する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、体重増加抑制のために使用される装置である、ことを特徴とする。 In some embodiments, the weight gain suppression device according to the present invention is a device for suppressing weight gain by irradiating a living body with violet light at a constant light or at a specific flickering frequency, wherein the violet light emits light. a light source, a light emission cycle control unit that makes the violet light a constant light or a specific flickering frequency, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period, for suppressing weight gain It is characterized by being a device used.
　また、本発明に係る体重増加抑制装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して体重増加抑制を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the weight gain suppression device according to the present invention is a device that irradiates a living body with constant violet light to promote weight gain suppression, comprising: a light source that emits the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る体重増加抑制装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって体重増加抑制効果を生じさせる特定波長の光である、光刺激による体重増加抑制装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the weight gain suppressing device according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is delivered to the living body. The present invention relates to a device for suppressing weight gain using photostimulation, which is light of a specific wavelength that produces a weight gain suppressing effect when irradiated. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による体重増加抑制装置の作動方法に関する。よって、本発明の一部の実施形態は、体重の増加抑制に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating a weight gain suppressing device using optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in reducing weight gain, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による体重増加抑制方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して体重増加抑制を促進する方法であって、前記光を受けた前記生体において体重増加抑制が促進される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において体重増加抑制を促進するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において体重増加抑制が促進される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for suppressing weight gain by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency to promote suppression of weight gain, wherein the body that receives the light loses weight. It relates to a method, characterized in that the suppression of growth is facilitated. More specifically, some embodiments of the present invention provide a method for promoting weight reduction in a subject in need of treatment, comprising exposing the subject to constant or specific wavelengths of light. A method comprising irradiating a living body with a flickering frequency, thereby promoting suppression of weight gain in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、体重の増加抑制には、代謝の活性化、脂肪燃焼の促進、ミトコンドリアの活性化が関与すると考えられることから、本発明の一つの側面は、生体における代謝の活性化効果を生じさせる特定波長の光を生体へ照射するように構成された代謝活性化装置及びその作動方法、又は代謝活性化効果を生じさせる特定波長の光を生体へ照射する段階を含む代謝活性化方法にも関する。そして、いくつかの実施形態は、脂肪燃焼の促進効果を生じさせる特定波長の光を生体へ照射するように構成された脂肪燃焼の促進装置及びその作動方法、又は脂肪燃焼の促進効果を生じさせる特定波長の光を生体へ照射する段階を含む脂肪燃焼の促進方法に関する。さらに、いくつかの実施形態は、ミトコンドリアの活性化効果を生じさせる特定波長の光を生体へ照射するように構成されたミトコンドリアの活性化装置及びその作動方法、又はミトコンドリアの活性化効果を生じさせる特定波長の光を生体へ照射する段階を含むミトコンドリアの活性化方法にも関する。 In addition, since the suppression of body weight gain is thought to involve activation of metabolism, promotion of fat burning, and activation of mitochondria, one aspect of the present invention is a specific The present invention also relates to a metabolic activation device configured to irradiate a living body with light of a wavelength and a method of operating the same, or a metabolic activation method including a step of irradiating a living body with light of a specific wavelength that produces a metabolic activation effect. In some embodiments, a fat burning promoting device configured to irradiate a living body with light of a specific wavelength that produces a fat burning promoting effect and an operating method thereof, or a fat burning promoting effect is produced. The present invention relates to a method for promoting fat burning, including the step of irradiating a living body with light of a specific wavelength. Further, some embodiments are a mitochondrial activation device configured to irradiate a living body with light of a specific wavelength that produces a mitochondrial activation effect, and a method of operating the same, or a mitochondrial activation effect. It also relates to a method for activating mitochondria, which includes the step of irradiating a living body with light of a specific wavelength.
　［副交感神経活性化促進装置及び方法］
　本発明者らは、さらにバイオレットライトによる副交感神経への影響についての研究を行った。その結果、バイオレットライトの照射による光刺激により、副交感神経の活性化を促進できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る副交感神経活性化促進方法及び装置を完成するに至った。 [Device and method for promoting parasympathetic nerve activation]
The present inventors further conducted research on the effects of violet light on parasympathetic nerves. As a result, it was found that the activation of parasympathetic nerves can be promoted by light stimulation by irradiating violet light. Then, based on the knowledge of such an effect of light stimulation by violet light, the inventors completed the parasympathetic nerve activation promoting method and apparatus according to the present invention.
　いくつかの実施形態において、本発明に係る副交感神経の活性化促進装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して副交感神経の活性化を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、副交感神経の活性化促進のために使用される装置である、ことを特徴とする。 In some embodiments, the parasympathetic nerve activation promoting device according to the present invention is a device for promoting the activation of the parasympathetic nerve by irradiating a living body with violet light at constant light or at a specific flickering frequency, A light source that emits violet light, a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency, and a light emission time control unit that irradiates the violet light for a specific time or a specific period, and is parasympathetic. The device is characterized by being a device used to promote activation of nerves.
　また、本発明に係る副交感神経活性化装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して副交感神経の活性化を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the parasympathetic nerve activation device according to the present invention is a device for irradiating a living body with constant light of violet light to promote activation of the parasympathetic nerve, wherein the violet light is emitted. It is characterized by comprising a light source and a light emission time control section for irradiating the violet light for a specific time or for a specific period.
　また、本発明に係る副交感神経活性化装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって副交感神経活性化効果を生じさせる特定波長の光である、光刺激による副交感神経活性化装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the parasympathetic nerve activation device according to the present invention includes at least one light source that emits light, and a drive circuit that drives the light source. The present invention relates to a device for activating a parasympathetic nerve by light stimulation, which is light of a specific wavelength that causes a parasympathetic nerve activation effect by irradiating the device. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による副交感神経活性化促進装置の作動方法に関する。よって、本発明の一部の実施形態は、副交感神経の活性化促進に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating a device for promoting parasympathetic nerve activation by optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in promoting parasympathetic activation, wherein the device irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a controller for controlling the blinking frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength at a constant light or at a specific blinking frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による副交感神経活性化促進方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して副交感神経活性化を促進する方法であって、前記光を受けた前記生体において副交感神経活性化が促進される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において副交感神経活性化を促進するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において副交感神経活性化が促進される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for promoting parasympathetic nerve activation by light stimulation. Therefore, some embodiments of the present invention provide a method for promoting parasympathetic nerve activation by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, comprising: The present invention relates to a method, characterized in that parasympathetic nerve activation is promoted. More specifically, some embodiments of the present invention provide a method for promoting parasympathetic activation in a subject in need of treatment, comprising directing a constant or specific wavelength of light to the subject. irradiating a living body with a blinking frequency of , whereby parasympathetic activation is promoted in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　また、副交感神経が優位となることにより、ストレス又は疲労感の軽減、便秘の解消がもたらされると考えられることから、本発明の一つの側面は、生体においてストレス又は疲労感の軽減効果を生じさせる特定波長の光を生体へ照射するように構成されたストレス又は疲労感の軽減装置及びその作動方法、又はストレス又は疲労感の軽減効果を生じさせる特定波長の光を生体へ照射する段階を含むストレス又は疲労感の軽減方法にも関する。そして、いくつかの実施形態は、便秘の解消効果を生じさせる特定波長の光を生体へ照射するように構成された便秘解消装置及びその作動方法、又は便秘解消効果を生じさせる特定波長の光を生体へ照射する段階を含む便秘解消方法に関する。このような装置又は方法は、便秘薬と組み合わせて使用されてもよい。 In addition, since it is thought that stress or fatigue is relieved and constipation is relieved by parasympathetic nerves becoming dominant, one aspect of the present invention is to produce an effect of reducing stress or fatigue in a living body. A stress or fatigue reduction device configured to irradiate a living body with light of a specific wavelength and its operation method, or a stress including a step of irradiating a living body with light of a specific wavelength that produces a stress or fatigue reduction effect Or it also relates to a method for reducing fatigue. Further, some embodiments are a constipation relieving device configured to irradiate a living body with light of a specific wavelength that produces constipation relieving effects, and an operating method thereof, or light of a specific wavelength that produces constipation relieving effects. The present invention relates to a method for relieving constipation, including the step of irradiating a living body. Such devices or methods may be used in combination with laxatives.
　［脳血流及び脳酸素濃度増加促進装置及び方法］
　本発明者らは、さらにバイオレットライトによる脳血流及び脳酸素濃度への影響についての研究を行った（脳の構造については図１を参照）。その結果、バイオレットライトの照射による光刺激により、脳血流及び脳酸素濃度の増加を促進できることがわかった。そして、バイオレットライトによる光刺激でのこうした効果の知見に基づき、本発明に係る脳血流及び脳酸素濃度増加促進方法及び装置を完成するに至った。 [Cerebral blood flow and cerebral oxygen concentration increase promoting device and method]
The present inventors further studied the effects of violet light on cerebral blood flow and cerebral oxygen concentration (see FIG. 1 for brain structure). As a result, it was found that the increase in cerebral blood flow and cerebral oxygen concentration can be promoted by light stimulation by irradiating violet light. Then, based on the knowledge of such effects of optical stimulation with violet light, the inventors completed the method and apparatus for promoting an increase in cerebral blood flow and cerebral oxygen concentration according to the present invention.
　いくつかの実施形態において、本発明に係る脳血流及び脳酸素濃度の増加促進装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して脳血流及び脳酸素濃度の増加を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、脳血流及び脳酸素濃度の増加促進のために使用される装置である、ことを特徴とする。 In some embodiments, the apparatus for promoting an increase in cerebral blood flow and cerebral oxygen concentration according to the present invention irradiates a living body with violet light at a constant light or at a specific flickering frequency to increase cerebral blood flow and cerebral oxygen concentration. a light source that emits the violet light; a light emission cycle control unit that makes the violet light a constant light or a specific flickering frequency; and a controller, and is a device used to promote an increase in cerebral blood flow and cerebral oxygen concentration.
　また、本発明に係る脳血流及び脳酸素濃度増加促進装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して脳血流及び脳酸素濃度の増加を促進する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 In some embodiments, the device for promoting cerebral blood flow and cerebral oxygen concentration increase according to the present invention is a device that promotes an increase in cerebral blood flow and cerebral oxygen concentration by irradiating a living body with normal violet light. and a light source that emits the violet light, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る脳血流及び脳酸素濃度増加促進装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって脳血流及び脳酸素濃度の増加促進効果を生じさせる特定波長の光である、光刺激による脳血流及び脳酸素濃度増加促進装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the device for promoting cerebral blood flow and cerebral oxygen concentration increase according to the present invention includes at least one light source that emits light and a drive circuit that drives the light source, and the light source is The emitted light is light of a specific wavelength that promotes an increase in cerebral blood flow and cerebral oxygen concentration by irradiating the living body. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による脳血流及び脳酸素濃度増加促進装置の作動方法に関する。よって、本発明の一部の実施形態は、脳血流及び脳酸素濃度の増加促進に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method for operating a device for promoting cerebral blood flow and cerebral oxygen concentration increase by optical stimulation. Accordingly, some embodiments of the present invention are methods of operating a device for use in promoting increased cerebral blood flow and cerebral oxygenation, wherein the device emits light of a specific wavelength at constant or at a specific flicker frequency. and a controller for controlling the flickering frequency of the light source, wherein the device irradiates the living body with light of a specific wavelength at a constant light or at a specific flickering frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による脳血流及び脳酸素濃度増加促進方法に関する。よって、本発明の一部の実施形態は、特定波長の光を常灯又は特定の点滅周波数で生体に照射して脳血流及び脳酸素濃度増加を促進する方法であって、前記光を受けた前記生体において脳血流及び脳酸素濃度増加が促進される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、処置を必要とする対象において脳血流及び脳酸素濃度増加を促進するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において脳血流及び脳酸素濃度増加が促進される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for promoting an increase in cerebral blood flow and cerebral oxygen concentration by light stimulation. Therefore, some embodiments of the present invention provide a method for promoting cerebral blood flow and cerebral oxygen concentration increase by irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency, comprising: and cerebral blood flow and increased cerebral oxygen concentration are promoted in said living body. More specifically, some embodiments of the present invention are a method for promoting cerebral blood flow and cerebral oxygenation in a subject in need of treatment comprising directing light of a particular wavelength to the subject. A method comprising irradiating a living body with constant light or a specific flickering frequency, thereby promoting cerebral blood flow and increased cerebral oxygen concentration in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　［光環境改善装置及び方法］
　本発明者らは、さらにバイオレットライトによる生体への好ましい影響に鑑み、バイオレットライトの照射による光刺激を利用した光環境改善装置及び方法を完成するに至った。 [Light environment improvement device and method]
In view of the positive effects of violet light on living organisms, the present inventors have completed a device and method for improving the light environment that utilizes the light stimulation of violet light irradiation.
　いくつかの実施形態において、本発明に係る光環境改善装置は、例えば、自宅でのリモートワークの継続により、日光を十分に浴びたり、適度な量の運動をしたりできない環境下においても、生体の睡眠や血糖値、脳血流に好ましい影響を与えることにより、室内での作業環境を改善することができる。よって、本発明に係る光環境改善装置は、バイオレットライトを常灯又は特定の点滅周波数で生体に照射して生体機能を制御する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、生体機能の制御の改善のために使用される装置である、ことを特徴とする。本発明に係るいくつかの実施形態では、生体機能の制御は、生体の体温の制御、体温の制御、体重の制御、血中グルコース濃度の制御、涙液量の制御、副交感神経活性化の制御、睡眠効率又は睡眠の質の制御、脳血流及び脳酸素濃度の制御に関するが、これらに限定はされない。また、いくつかの実施形態において、光源はバイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズと組み合わせて使用されてもよい。また、バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを通過した日光を光源として利用してもよい。例えば、バイオレットライトを通過させるガラスを利用しためがね又はコンタクトレンズは、通常のレンズを利用しためがね又はコンタクトレンズよりも、生体機能制御効果が高いことが理解される。 In some embodiments, the light environment improvement device according to the present invention can be used in a living environment even in an environment where it is not possible to take sufficient sunlight or exercise a moderate amount due to continuous remote work at home, for example. It is possible to improve the indoor work environment by having a favorable influence on sleep, blood sugar level, and cerebral blood flow. Therefore, the optical environment improving device according to the present invention is a device for controlling biological functions by irradiating a living body with violet light at a constant light or at a specific flickering frequency, comprising: a light source emitting the violet light; a constant light or a specific flickering frequency, and a light emission time control unit that irradiates the violet light for a specific time or for a specific period, and is used to improve control of biological functions. A device. In some embodiments of the present invention, the control of biological function is control of body temperature, body temperature control, body weight control, blood glucose level control, tear volume control, parasympathetic nerve activation control , control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation, but are not limited thereto. Also, in some embodiments, the light source may be used in combination with glasses, spectacle lenses, or contact lenses that allow violet light to pass through. Alternatively, sunlight passing through glasses, spectacle lenses, or contact lenses that allow violet light to pass through may be used as a light source. For example, it is understood that spectacles or contact lenses using glass that allows violet light to pass through have a higher biological function control effect than spectacles or contact lenses using normal lenses.
　また、本発明に係る光環境改善装置は、いくつかの実施形態において、バイオレットライトの常灯光を生体に照射して生体機能を制御する装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える、ことを特徴とする。 Further, in some embodiments, the optical environment improving device according to the present invention is a device for controlling a biological function by irradiating a living body with normal violet light, comprising: a light source emitting the violet light; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period.
　また、本発明に係る光環境改善装置は、いくつかの実施形態において、光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、光刺激による光環境改善装置に関する。いくつかの態様において、本発明に係る装置が有する駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含む。 In some embodiments, the optical environment improving device according to the present invention includes at least one light source that emits light and a driving circuit that drives the light source, and the light emitted by the light source is delivered to the living body. The present invention relates to a device for improving a light environment by light stimulation, which is light of a specific wavelength that produces a biological function control effect when irradiated. In some aspects, an apparatus according to the present invention comprises a drive circuit comprising: at least one processor communicatively coupled to the light source and at least one memory; including memory.
　また、本発明の一つの側面は、光刺激による光環境改善装置の作動方法に関する。よって、本発明の一部の実施形態は、光環境改善に用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記装置が特定波長の光を常灯又は特定の点滅周波数で生体に照射する、作動方法に関する。ここで、前記光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。加えて、本発明の一つの側面は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に上記の作動方法を実行させるコンピュータプログラムにも関する。 In addition, one aspect of the present invention relates to a method of operating a device for improving the optical environment by optical stimulation. Accordingly, some embodiments of the present invention are a method of operating a device for use in improving the lighting environment, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at constant light or at a specific flickering frequency. and a control unit for controlling the flickering frequency of the light source, wherein the device irradiates a living body with light of a specific wavelength in a normal light or at a specific flickering frequency. Here, the blinking frequency of the light source may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. In addition, one aspect of the present invention provides a device comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency, and a controller for controlling the blinking frequency of the light source. It also relates to a computer program for carrying out the method.
　さらに、本発明の一つの側面は、光刺激による光環境改善方法に関する。よって、本発明の一部の実施形態は、室内環境を改善するために、特定波長の光を常灯又は特定の点滅周波数で生体に照射してする方法であって、前記光を受けた前記生体において生体機能が制御される、ことを特徴とする、方法に関する。より具体的には、本発明の一部の実施形態は、室内環境を改善するために、処置を必要とする対象において生体機能を制御するための方法であって、対象に対して特定波長の光を常灯又は特定の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において生体機能が制御される、方法に関する。ここで、使用される光源の点滅周波数は０Ｈｚ又は３０～７５Ｈｚの範囲において制御されてもよく、また、前記光源は、３５０～４００ｎｍの範囲の波長の光を生体に照射するものであってもよい。 Furthermore, one aspect of the present invention relates to a method for improving the light environment by light stimulation. Therefore, some embodiments of the present invention provide a method of irradiating a living body with light of a specific wavelength at a constant light or a specific flickering frequency in order to improve an indoor environment, A method, characterized in that a biological function is controlled in a living organism. More specifically, some embodiments of the present invention are a method for controlling bodily functions in a subject in need of treatment to improve the indoor environment, comprising: It relates to a method comprising the step of irradiating a living body with light at constant light or at a specific flickering frequency, whereby a biological function is controlled in said living body receiving said light. Here, the blinking frequency of the light source used may be controlled in the range of 0 Hz or 30 to 75 Hz, and the light source may irradiate the living body with light having a wavelength in the range of 350 to 400 nm. good.
　さらに、本発明の一つの側面は、光刺激による光環境改善器具に関し、前記器具は、バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを含むものでありうる。このような器具を使用することで、生体機能に好ましい影響を及ぼすことができる。このような器具を使用することで可能となる生体機能の制御は、生体の体温の制御、体温の制御、体重の制御、血中グルコース濃度の制御、涙液量の制御、副交感神経活性化の制御、睡眠効率又は睡眠の質の制御、脳血流及び脳酸素濃度の制御を含むが、これらに限定はされない。他の生体機能の制御は、角膜性疾患の予防又は治療、ドライアイの予防又は治療、睡眠障害やそれに関する疾患の予防又は治療、睡眠障害の予防又は治療、時差ぼけの解消、睡眠導入、眠気の抑制、糖尿病の予防、慢性腎障害、動脈硬化、脳梗塞、若しくは痛風の予防、肥満の防止、老化関連疾患の予防、代謝の活性化、脂肪燃焼の促進、ミトコンドリア活性化の促進、ストレス又は疲労感の軽減、便秘の解消を含むが、これらに限定はされない。 Furthermore, one aspect of the present invention relates to a device for improving the light environment by light stimulation, and the device may include glasses, spectacle lenses, or contact lenses that allow violet light to pass through. The use of such devices can positively affect bodily functions. The control of biological functions that can be achieved by using such devices includes the control of body temperature, body temperature control, body weight control, blood glucose concentration control, tear volume control, and parasympathetic nerve activation control. including, but not limited to, control, control of sleep efficiency or quality, control of cerebral blood flow and cerebral oxygenation. Control of other biological functions includes the prevention or treatment of corneal diseases, the prevention or treatment of dry eye, the prevention or treatment of sleep disorders and related diseases, the prevention or treatment of sleep disorders, the elimination of jet lag, the induction of sleep, and drowsiness. suppression of diabetes, prevention of chronic kidney disease, arteriosclerosis, cerebral infarction, or gout, prevention of obesity, prevention of aging-related diseases, activation of metabolism, promotion of fat burning, promotion of mitochondrial activation, stress or This includes, but is not limited to, reducing fatigue and relieving constipation.
　（短波長光の受光による身体への影響）
　以下、短波長光の受光による身体への影響について順に詳細に説明する。なお、本明細書では、バイオレットライトを「ＶＬ」とも表す。バイオレットライトは３６０～４００ｎｍの波長光を用い、放射照度で０．５～１０００μＷ／ｃｍ２の範囲内で点滅照射した。 (Influence on the body by receiving short-wavelength light)
In the following, the influence of short-wavelength light reception on the body will be described in detail. In this specification, violet light is also expressed as "VL". Violet light used light with a wavelength of 360 to 400 nm, and flashing irradiation was performed within the irradiance range of 0.5 to 1000 μW/cm 2 .
　（バイオレットライト照射による体温への影響）
　バイオレットライトを午前中９時１０分から１２時１３分までの約３時間、バイオレットライトＬＥＤ付属したメガネ型バイオレットライト照射装置によって男女３名ずつ計６名（平均年齢２３．２±０．９歳）へ１０日間照射した。バイオレットライト照射する前に９日間、光刺激なしの日の計測との比較を行っている。光照射あり、もしくは光照射なしの条件での、光刺激中もしくは光刺激した日の就寝１時間前、就寝時の被験者の体温測定を毎日行った。以下の表１および２ならびに図６および７に示される結果から、就寝時の体温低下が有意に光刺激によって誘発されていることから、体温の階日リズムの修正と睡眠誘導が促進されていることが考えられる。 (Effect of violet light irradiation on body temperature)
Violet light for about 3 hours from 9:10 to 12:13 in the morning, 6 people (average age 23.2 ± 0.9 years old), 3 men and 3 women, using a glasses-type violet light irradiation device with a violet light LED. were irradiated for 10 days. A comparison is made with measurements taken on days without light stimulation for 9 days before irradiation with violet light. The body temperature of the subjects was measured every day, one hour before bedtime and at bedtime during or on the day of light stimulation, with or without light irradiation. From the results shown in Tables 1 and 2 and FIGS. 6 and 7 below, since the decrease in body temperature at bedtime is significantly induced by light stimulation, the correction of the circadian rhythm of body temperature and the induction of sleep are promoted. can be considered.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
　また、４４週齢のマウス（Ｃ５７Ｂｌ６／Ｊ）マウスを白色ＬＥＤの環境（ｃＷＬ）と、白色のＬＥＤとバイオレットライトＬＥＤを組み合わせた光環境（ｃＷＬ＋ｃＶＬ）下で飼育し、直腸温度計を用いて午前中の１０～１２時の間に体温を測定した（それぞれｎ＝４０）。観察は７０週齢まで行った。その結果、太陽光に近い光環境を室内にて再現した白色＋バイオレットライトの光環境で、体温の低下が観察された（図８）。体温の低下はカロリー制限時に見られ、肥満に対する耐性や疾患の予防などが報告されている（Lane et al., PNAS April 30, 1996 93 (9) 4159-4164, https://doi.org/10.1073/pnas.93.9.4159; Kotani et al., Aging Cell (2005) 4, pp147-155, https://doi.org/10.1111/j.1474-9726.2005.00157.x）。通常の白色蛍光灯、ＬＥＤなどのお室内環境と比較して、外の光環境に近いバイオレットライトを加えることによって、体温調整が可能となる。また体温の抑制を介した肥満の防止、老化関連疾患の予防効果が考えられる。 In addition, 44-week-old mice (C57Bl6/J) were bred under a white LED environment (cWL) and a light environment combining a white LED and a violet light LED (cWL + cVL). Body temperature was measured between 10 and 12 hours (n=40 each). Observation was continued until 70 weeks of age. As a result, a decrease in body temperature was observed in a white + violet light environment that reproduced a light environment similar to sunlight indoors (Fig. 8). A decrease in body temperature is observed during calorie restriction, and resistance to obesity and disease prevention have been reported (Lane et al., PNAS April 30, 1996 93 (9) 4159-4164, https://doi.org/ 10.1073/pnas.93.9.4159; Kotani et al., Aging Cell (2005) 4, pp147-155, https://doi.org/10.1111/j.1474-9726.2005.00157.x). By adding a violet light that is closer to the outdoor light environment than the indoor environment such as ordinary white fluorescent lamps and LEDs, it is possible to regulate the body temperature. It is also thought to be effective in preventing obesity and aging-related diseases through suppression of body temperature.
　図１３は、入眠８時間前からの体温変化を示したグラフである。８名の被験者の平均体温変化（Ｘ軸）と体温（Ｙ軸）が示されている。体温が入眠時にしっかり低下することが重要と考えられており、入眠がＶＬによって促進されていることを示している。上記の表２は睡眠の質のデータである一方、こちらは入眠の促進に視点を置いている。 Fig. 13 is a graph showing changes in body temperature from 8 hours before falling asleep. Mean body temperature change (X-axis) and body temperature (Y-axis) for eight subjects are shown. It is considered important for body temperature to drop steadily at sleep onset, indicating that sleep onset is promoted by VL. While Table 2 above is sleep quality data, this one focuses on promoting sleep onset.
　図１４は、睡眠前後及び覚醒時の体温変化を示したグラフである。就眠前にＰＣやスマホを使うことが多く、睡眠前後で体温が不均一なことが多く、対照（ＶＬ無し）でそのような現象が観察されている。ＶＬ照射の介入によって体温が睡眠前に安定し、入眠時に徐々に低下している。これは概日周期が整い、入眠が促進されていることを示唆している。 FIG. 14 is a graph showing changes in body temperature before and after sleep and during wakefulness. They often use PCs and smartphones before going to bed, and their body temperature is often uneven before and after sleep, and such a phenomenon was observed in the control (without VL). With the intervention of VL irradiation, the body temperature stabilizes before sleep and gradually decreases at sleep onset. This suggests that the circadian cycle is in order and sleep onset is promoted.
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、体温低下を促進できることを示している。 The above results show that body temperature reduction can be promoted by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　（バイオレットライト照射による血糖値への影響）
　バイオレットライトを午前中９時１０分から１２時１３分までの約３時間、バイオレットライトＬＥＤ付属したメガネ型バイオレットライト照射装置によって男女３名ずつ計６名（平均年齢２３．２±０．９歳）へ１０日間照射した。バイオレットライト照射する前に９日間、光刺激なしの日の計測との比較を行っている。光照射あり、もしくは光照射なしの条件下で、間質液中グルコース濃度を２４時間測定した。昼食後の間質液中グルコース濃度を測定した結果、表３に示されるように、光照射群ではグルコース濃度の上昇が抑制されている（有意水準１％で平均値に差がある（ｐ＜０．０１））。この結果から、食事による血糖値の上昇を抑制する機能がバイオレットライトの光照射によって得られることが分かる。 (Effect of violet light irradiation on blood sugar level)
Violet light for about 3 hours from 9:10 to 12:13 in the morning, 6 people (average age 23.2 ± 0.9 years old), 3 men and 3 women, using a glasses-type violet light irradiation device with a violet light LED. were irradiated for 10 days. A comparison is made with measurements taken on days without light stimulation for 9 days before irradiation with violet light. Glucose concentrations in interstitial fluid were measured for 24 hours under conditions with and without light irradiation. As a result of measuring the glucose concentration in the interstitial fluid after lunch, as shown in Table 3, the increase in glucose concentration was suppressed in the light irradiation group (there is a difference in the mean value at the significance level of 1% (p < 0.01)). From these results, it can be seen that the violet light irradiation has the function of suppressing the increase in blood sugar level caused by meals.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　図１５および図１６は、バイオレットライト照射による１週間を通じた血中グルコースの低下を示している。４０代女性の実験において毎日３時間のバイオレット照射によって日々の血中グルコースを制御することができることが示された。若い人だけでなく、中年期など、年齢に依存せず効果が得られることが理解される。 　Figures 15 and 16 show the decrease in blood glucose over a week due to violet light irradiation. It was shown in an experiment with a woman in her 40s that daily blood glucose could be controlled by violet irradiation for 3 hours every day. It is understood that the effect can be obtained regardless of age, such as middle-aged people as well as young people.
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、血中グルコース濃度を低減又は増加抑制できることを示している。 The above results show that the blood glucose concentration can be reduced or suppressed from increasing by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　（バイオレットライトが体重に及ぼす影響）
　４４週齢のマウス（Ｃ５７Ｂｌ６／Ｊ）マウスを白色ＬＥＤの環境（ｃＷＬ）と、白色のＬＥＤとバイオレットライトＬＥＤを組み合わせた光環境（ｃＷＬ＋ｃＶＬ）下で飼育し、直腸温度計を用いて午前中の１０～１２時の間に体重を測定した（それぞれｎ＝４０）。観察は７０週齢まで行った。その結果、太陽光に近い光環境を室内にて再現した白色＋バイオレットライトの光環境で、体重の低下が観察された（図９）。低体温の遺伝子操作されたマウスや、カロリー制限、成長ホルモンＧＨ欠損マウスなどでは寿命が延長され、体重に対する酸素消費量が多いなど代謝が活発化していることが知られている（Conti et al., Science　 03 Nov 2006: Vol. 314, Issue 5800, pp. 825-828, DOI: 10.1126/science.1132191; Bartke & Westbrook, Front. Genet., 13 December 2012, https://doi.org/10.3389/fgene.2012.00288）。バイオレットライトの光刺激は、代謝を活性化するなど体重低下を制御することが可能であることが考えられる。 (Effect of violet light on body weight)
44-week-old mice (C57Bl6/J) were bred under a white LED environment (cWL) and a light environment combining a white LED and a violet light LED (cWL+cVL), and were measured using a rectal thermometer in the morning. Body weights were measured between 10 and 12 hours (n=40 each). Observation was continued until 70 weeks of age. As a result, a decrease in body weight was observed in a light environment of white + violet light that reproduced a light environment close to sunlight indoors (Fig. 9). Genetically engineered hypothermic mice, calorie-restricted mice, and growth hormone GH-deficient mice are known to have extended lifespans and increased metabolic activity, such as high oxygen consumption relative to body weight (Conti et al. , Science 03 Nov 2006: Vol. 314, Issue 5800, pp. 825-828, DOI: 10.1126/science.1132191; Bartke & Westbrook, Front. Genet., 13 December 2012, https://doi.org/10.3389/ fgene.2012.00288). Violet light stimulation is thought to be able to control weight loss by activating metabolism.
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、体重増加を抑制できることを示している。 The above results show that weight gain can be suppressed by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　（バイオレットライトが涙液量に及ぼす影響）
　バイオレットライトを午前中９時１０分から１２時１３分までの約３時間、バイオレットライトＬＥＤ付属したメガネ型バイオレットライト照射装置によって男女３名ずつ計６名（平均年齢２３．２±０．９歳）へ１０日間照射した。バイオレットライト照射する前に９日間、光刺激なしの日の計測との比較を行っている。涙液を、ストリップメニスコメトリ検査紙を用いて、光照射時間帯の９時間に測定し、再度光照射時間帯後の１２時１３分以降に測定している。通常、涙液は午前中から午後にかけて減少するが、表４および図１０に示されるように、バイオレットライト照射によって涙液が増加している。この結果はバイオレットライトが涙液を促進すると同時に、涙液の概日周期による低下を抑制していることが考えられる。涙液量の増加は、ドライアイや涙液量の低下に伴う角膜性疾患の防止と治療効果が期待される。 (Effect of violet light on tear volume)
Violet light for about 3 hours from 9:10 to 12:13 in the morning, 6 people (average age 23.2 ± 0.9 years old), 3 men and 3 women, using a glasses-type violet light irradiation device with a violet light LED. were irradiated for 10 days. A comparison is made with measurements taken on days without light stimulation for 9 days before irradiation with violet light. Tear fluid was measured using a strip meniscometry test paper at 9 hours of the light exposure period and again after 12:13 after the light exposure period. Normally, tear fluid decreases from morning to afternoon, but as shown in Table 4 and FIG. 10, violet light irradiation increases tear fluid. This result suggests that violet light promotes tear production and at the same time suppresses the reduction of tear production due to the circadian cycle. Increased tear volume is expected to be effective in preventing and treating dry eye and corneal diseases associated with decreased tear volume.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、涙液量の増加を促進できることを示している。 The above results show that an apparatus for irradiating a living body with light of a specific wavelength can be used to irradiate a living body with light of a specific wavelength, thereby promoting an increase in the amount of tear fluid.
　（バイオレットライトが副交感神経に及ぼす影響）
　バイオレットライトを午前中９時１０分から１２時１３分までの約３時間、バイオレットライトＬＥＤ付属したメガネ型バイオレットライト照射装置によって男女３名ずつ計６名（平均年齢２３．２±０．９歳）へ１０日間照射した。心拍数をバイオレットライト刺激の有無中の３時間測定した。心拍数の測定によって０．００４～０．１５Ｈｚの周波数帯のパワースペクトルＬＦ（低周波　ｍｓ２）と０．１５～０．４Ｈｚの周波帯のパワースペクトルＨＦ（高周波　ｍｓ２）を抽出し、ＬＦ（低周波）の比率とＨＦ（高周波）のパワーの比率を計測した。数値が高いと交感神経優位を、低い場合は副交感神経優位を示している。表５に示されているように、バイオレットライト照射によって、ＬＨ／ＨＦ比率が低下し、副交感神経優位になっていることが示唆される。これらの結果は、バイオレットライト照射によって副交感神経優位となり、リラックス効果、インスリン分泌の促進、血流の促進効果が得られることが理解される。 (Effect of violet light on parasympathetic nerves)
Violet light for about 3 hours from 9:10 to 12:13 in the morning, 6 people (average age 23.2 ± 0.9 years old), 3 men and 3 women, using a glasses-type violet light irradiation device with a violet light LED. were irradiated for 10 days. Heart rate was measured for 3 hours with and without violet light stimulation. By measuring the heart rate, the power spectrum LF (low frequency ms 2 ) in the frequency band of 0.004 to 0.15 Hz and the power spectrum HF (high frequency ms 2 ) in the frequency band of 0.15 to 0.4 Hz are extracted, and LF (low frequency) ratio and the ratio of HF (high frequency) power were measured. A high value indicates sympathetic nerve dominance, and a low value indicates parasympathetic nerve dominance. As shown in Table 5, violet light irradiation reduces the LH/HF ratio, suggesting parasympathetic nerve dominance. From these results, it is understood that irradiation with violet light makes the parasympathetic nervous system dominant, and that relaxation effects, promotion of insulin secretion, and promotion of blood flow can be obtained.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、副交感神経の活性化を促進できることを示している。 The above results show that the activation of the parasympathetic nerve can be promoted by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　（バイオレットライト照射による脳血流量への影響）
　バイオレットライトを被験者５名に２０分間照射し、３０分間前頭前野における脳酸素濃度を７５ｍｓのサンプリング間隔にて、脳血流動態計測ＮＩＲＳ（近赤外分光法）を用いて測定した。実験は、安静閉眼５分、作業２０分、安静閉眼５分を１セットとし、作業２０分間に光照射を行った。安静閉眼時の脳血流動態計測を行っている。血中酸素化ヘモグロビン濃度（Ｏｘｙ－Ｈｂ）と血中脱酸素化ヘモグロビン濃度（Ｄｅｏｘｙ－Ｈｂ）を解析している。図１１に示されているように、Ｏｘｙ－Ｈｂ分散がバイオレットライト照射によって増加することから、脳血流の増大と、脳の活性化が理解される。 (Effect of violet light irradiation on cerebral blood flow)
Five subjects were irradiated with violet light for 20 minutes, and the cerebral oxygen concentration in the prefrontal cortex for 30 minutes was measured using cerebral hemodynamic measurement NIRS (near infrared spectroscopy) at a sampling interval of 75 ms. In the experiment, one set consisted of 5 minutes of rest with eyes closed, 20 minutes of work, and 5 minutes of rest with eyes closed, and light irradiation was performed during 20 minutes of work. Cerebral hemodynamics are being measured while the eyes are closed at rest. Blood oxygenated hemoglobin concentration (Oxy-Hb) and blood deoxygenated hemoglobin concentration (Deoxy-Hb) are analyzed. As shown in FIG. 11, the Oxy-Hb dispersion increased by violet light irradiation, which indicates an increase in cerebral blood flow and activation of the brain.
　図１７は脳血流動態の平均分布を示しており、前頭部における脱酸素化ヘモグロビンの増加の傾向が見られた。右脳で酸素消費が増加していることから、創造力、芸術、柔軟性の促進や、もやもや病、失行症、失認症などへ本技術を応用することが考えられる。 Fig. 17 shows the average distribution of cerebral hemodynamics, showing a trend of increased deoxygenated hemoglobin in the frontal region. Oxygen consumption is increased in the right hemisphere, suggesting that this technology could be applied to promote creativity, art, and flexibility, and to treat moyamoya disease, apraxia, and agnosia.
　図１８は、図１７の結果を前頭葉全体の定量により補足したものである。前頭部における酸素化ヘモグロビン低下と、脱酸素化ヘモグロビンの増加の傾向が見られた。以下の表６に数値をまとめた。 Fig. 18 supplements the results of Fig. 17 by quantifying the entire frontal lobe. A trend toward decreased oxygenated hemoglobin and increased deoxygenated hemoglobin in the forehead was observed. The numerical values are summarized in Table 6 below.
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、脳血流の増加を促進できることを示している。 The above results show that an increase in cerebral blood flow can be promoted by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　（バイオレットライト照射による睡眠の質への影響）
　男性６名（年齢２２．６３±０．７）へ午前９時から１１時までの２時間バイオレットライトを照射し、２４時以降の睡眠時における睡眠深度と質を測定した。脳波・眼球運動・心電図・筋電図・呼吸曲線・いびき・動脈血酸素飽和度などの生体活動を、一晩にわたって測定する検査する終夜睡眠ポリグラフ検査（ＰＳＧ検査）を１人の被験者あたりに３回行っている。ＰＳＧ検査の解析によって、ＷＫ、Ｎ１、Ｎ２、Ｎ３、ＲＥＭの５段階で睡眠段階を評価することができる。睡眠はＷＫからＲＥＭに従って深い睡眠となる。図１２に示されているように、バイオレットライト照射によって、Ｎ１の浅い睡眠時間が短縮し、Ｎ２の睡眠が延長している。また、眠りが浅く、夜中にしばしば目がさめる症状の中途覚醒が減少している。これらのバイオレットライトの効果は、日光を浴びた際の睡眠への効果と同程度の高い効果が得られている。これらの結果は、バイオレットライトの照射が睡眠深度と質を向上させ、睡眠障害やそれに関する疾患を予防、治療できることを示唆している。 (Effect of violet light irradiation on sleep quality)
Six men (age 22.63±0.7) were irradiated with violet light for 2 hours from 9:00 am to 11:00 am, and the depth and quality of sleep after 24:00 were measured. All-night polysomnography (PSG test), which measures biological activity such as electroencephalogram, eye movement, electrocardiogram, electromyogram, respiratory curve, snoring, arterial blood oxygen saturation, etc., three times per subject. Is going. Analysis of the PSG test allows assessment of sleep stages in five stages: WK, N1, N2, N3, and REM. Sleep becomes deep sleep from WK to REM. As shown in FIG. 12, violet light irradiation shortens light sleep time in N1 and prolongs sleep in N2. In addition, the symptoms of light sleep and frequent awakening in the middle of the night are reduced. The effect of these violet lights is as high as the effect on sleep when exposed to sunlight. These results suggest that violet light irradiation can improve the depth and quality of sleep, and prevent and treat sleep disorders and related diseases.
　以上の結果は、特定波長の光を生体に照射する装置を用いて、生体に特定波長の光を照射することにより、生体の睡眠効率又は睡眠の質を改善できることを示している。 The above results show that the sleep efficiency or sleep quality of a living body can be improved by irradiating a living body with light of a specific wavelength using a device that irradiates a living body with light of a specific wavelength.
　上記の実施形態の一部または全部は、以下の付記のようにも記載されうるが、本出願の開示事項は以下の付記に限定されない。 Some or all of the above embodiments can also be described as the following additional notes, but the disclosure of the present application is not limited to the following additional notes.
（付記１）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、光刺激による生体機能制御装置。
（付記２）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって涙液量増加促進効果を生じさせる特定波長の光である、光刺激による涙液量増加促進装置。
（付記３）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって睡眠効率又は睡眠の質の改善効果を生じさせる特定波長の光である、光刺激による睡眠効率又は睡眠の質の改善装置。
（付記４）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって血中グルコース濃度低減又は増加抑制効果を生じさせる特定波長の光である、光刺激による血中グルコース濃度低減又は増加抑制装置。
（付記５）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって体温低下促進効果を生じさせる特定波長の光である、光刺激による体温低下促進装置。
（付記６）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって体重増加抑制効果を生じさせる特定波長の光である、光刺激による体重増加抑制装置。
（付記７）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって副交感神経活性化効果を生じさせる特定波長の光である、光刺激による副交感神経活性化促進装置。
（付記８）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって脳血流及び脳酸素濃度増加促進効果を生じさせる特定波長の光である、光刺激による脳血流及び脳酸素濃度増加促進装置。
（付記９）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、光刺激による光環境改善装置。
（付記１０）
　前記光はバイオレットライトである、付記１～９のいずれか一項記載の装置。
（付記１１）
　前記特定波長は３５０～４００ｎｍを含む、付記１～１０のいずれか一項記載の装置。
（付記１２）
　前記特定波長は約３８０ｎｍを含む、付記１１記載の装置。
（付記１３）
　光の点滅周波数が０Ｈｚ又は３０～７０Ｈｚである、付記１～１２のいずれか１項記載の装置。
（付記１４）
　前記点滅周波数は０Ｈｚ又は３５～６０Ｈｚである、付記１３記載の装置。
（付記１５）
　前記点滅周波数は０Ｈｚ又は約４０Ｈｚである、付記１４記載の装置。
（付記１６）
　光の照射条件が、前記光源の照射時間を含む、付記１～１５のいずれか１項記載の装置。
（付記１７）
　前記光源は、光源付きめがね若しくはめがねフレーム、卓上光源、移動体端末装着光源、顔前又は近傍設置型光源、携帯光源、室内照明、又は卓上スタンドである、付記１～１６のいずれか１項記載の装置。
（付記１８）
　付記１～１７のいずれか一項記載の装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記制御部が、前記光源の点滅周波数を０Ｈｚ又は３０～７５Ｈｚの範囲において制御する段階、前記光源が、３５０～４００ｎｍの範囲の波長の光を生体に照射する段階を含む、作動方法。
（付記１９）
　前記特定波長が、約３８０ｎｍである、付記１８記載の作動方法。
（付記２０）
　前記特定の点滅周波数が、０Ｈｚ又は約４０Ｈｚである、付記１８または１９記載の作動方法。
（付記２１）
　前記制御部が、前記特定波長の光を照射する時間又は期間を制御する機能をさらに備え、前記制御部が、照射時間を１０秒～１００時間の範囲で制御する段階をさらに含む、付記１８～２０のいずれか一項記載の作動方法。
（付記２２）
　特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に付記１７～２１のいずれか一項に記載の作動方法を実行させるコンピュータプログラム。
（付記２３）
　処置を必要とする対象において、
　ａ）涙液量の増加を促進する、
　ｂ）睡眠効率又は睡眠の質を改善する、
　ｃ）血中グルコース濃度を低減又は増加抑制する、
　ｄ）体温低下を促進する、
　ｅ）体重増加を抑制する、
　ｆ）副交感神経の活性化を促進する、又は
　ｇ）脳血流及び脳酸素濃度増加を促進する
ための方法であって、対象に対して３５０～４００ｎｍの範囲の波長の光を０Ｈｚ又は３０～７５Ｈｚの範囲の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において上記効果が得られる、方法。
（付記２４）
　バイオレットライトを常灯又は特定の点滅周波数で生体に照射して、
　ａ）角膜性疾患の予防又は治療するための、
　ｂ）ドライアイを予防又は治療するための、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療するための、
　ｄ）睡眠障害を予防又は治療するための、
　ｅ）時差ぼけを解消するための、
　ｆ）睡眠を導入するための、
　ｇ）眠気を抑制するための、
　ｈ）糖尿病を予防するための、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防するための、
　ｊ）肥満を防止するための、
　ｋ）老化関連疾患を予防するための、
　ｌ）代謝を活性化するための、
　ｍ）脂肪燃焼を促進するための、
　ｎ）ミトコンドリアの活性化を促進するための、
　ｏ）ストレス又は疲労感を軽減するための、又は
　ｐ）便秘を解消するための、
装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを常灯又は特定の点滅周波数とする発光周期制御部と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備え、上記効果を得るために使用される装置。
（付記２５）
　バイオレットライトの常灯光を生体に照射して、
　ａ）角膜性疾患の予防又は治療する、
　ｂ）ドライアイを予防又は治療する、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療する、
　ｄ）睡眠障害を予防又は治療する、
　ｅ）時差ぼけを解消する、
　ｆ）睡眠を導入する、
　ｇ）眠気を抑制する、
　ｈ）糖尿病を予防する、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防する、
　ｊ）肥満を防止する、
　ｋ）老化関連疾患を予防する、
　ｌ）代謝を活性化する、
　ｍ）脂肪燃焼を促進する、
　ｎ）ミトコンドリアの活性化を促進する、
　ｏ）ストレス若しくは疲労感を軽減する、又は
　ｐ）便秘を解消する、
装置であって、前記バイオレットライトを発光する光源と、前記バイオレットライトを特定の時間又は特定の期間照射する発光時間制御部と、を備える装置。
（付記２６）
　光を発する少なくとも１つの光源と、前記光源を駆動する駆動回路と、を有し、前記光源が発する光は、生体へ照射することによって、
　ａ）角膜性疾患の予防又は治療する、
　ｂ）ドライアイを予防又は治療する、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療する、
　ｄ）睡眠障害を予防又は治療する、
　ｅ）時差ぼけを解消する、
　ｆ）睡眠を導入する、
　ｇ）眠気を抑制する、
　ｈ）糖尿病を予防する、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防する、
　ｊ）肥満を防止する、
　ｋ）老化関連疾患を予防する、
　ｌ）代謝を活性化する、
　ｍ）脂肪燃焼を促進する、
　ｎ）ミトコンドリアの活性化を促進する、
　ｏ）ストレス若しくは疲労感を軽減する、又は
　ｐ）便秘を解消する、
効果を生じさせる特定波長の光である、光刺激による装置。
（付記２７）
　ａ）角膜性疾患の予防又は治療する、
　ｂ）ドライアイを予防又は治療する、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療する、
　ｄ）睡眠障害を予防又は治療する、
　ｅ）時差ぼけを解消する、
　ｆ）睡眠を導入する、
　ｇ）眠気を抑制する、
　ｈ）糖尿病を予防する、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防する、
　ｊ）肥満を防止する、
　ｋ）老化関連疾患を予防する、
　ｌ）代謝を活性化する、
　ｍ）脂肪燃焼を促進する、
　ｎ）ミトコンドリアの活性化を促進する、
　ｏ）ストレス若しくは疲労感を軽減する、又は
　ｐ）便秘を解消する、
ために用いるための装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記制御部が、前記光源の点滅周波数を０Ｈｚ又は３０～７５Ｈｚの範囲において制御する段階、前記光源が、３５０～４００ｎｍの範囲の波長の光を生体に照射する段階を含む、作動方法。
（付記２８）
　特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に付記２６の作動方法を実行させるコンピュータプログラム。
（付記２９）
　処置を必要とする対象において、
　ａ）角膜性疾患の予防又は治療する、
　ｂ）ドライアイを予防又は治療する、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療する、
　ｄ）睡眠障害を予防又は治療する、
　ｅ）時差ぼけを解消する、
　ｆ）睡眠を導入する、
　ｇ）眠気を抑制する、
　ｈ）糖尿病を予防する、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防する、
　ｊ）肥満を防止する、
　ｋ）老化関連疾患を予防する、
　ｌ）代謝を活性化する、
　ｍ）脂肪燃焼を促進する、
　ｎ）ミトコンドリアの活性化を促進する、
　ｏ）ストレス若しくは疲労感を軽減する、又は
　ｐ）便秘を解消する、
ための方法であって、対象に対して３５０～４００ｎｍの範囲の波長の光を０Ｈｚ又は３０～７５Ｈｚの範囲の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において上記効果が得られる、方法。
（付記３０）
　バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを含む、光刺激による光環境改善器具。
（付記３１）
　処置を必要とする対象において、
　ａ）涙液量の増加を促進する、
　ｂ）睡眠効率又は睡眠の質を改善する、
　ｃ）血中グルコース濃度を低減又は増加抑制する、
　ｄ）体温低下を促進する、
　ｅ）体重増加を抑制する、
　ｆ）副交感神経の活性化を促進する、又は
　ｇ）脳血流及び脳酸素濃度増加を促進する
ための器具であって、バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを含む、器具。
（付記３２）
　処置を必要とする対象において、
　ａ）角膜性疾患の予防又は治療する、
　ｂ）ドライアイを予防又は治療する、
　ｃ）睡眠障害やそれに関する疾患の予防又は治療する、
　ｄ）睡眠障害を予防又は治療する、
　ｅ）時差ぼけを解消する、
　ｆ）睡眠を導入する、
　ｇ）眠気を抑制する、
　ｈ）糖尿病を予防する、
　ｉ）慢性腎障害、動脈硬化、脳梗塞、又は痛風を予防する、
　ｊ）肥満を防止する、
　ｋ）老化関連疾患を予防する、
　ｌ）代謝を活性化する、
　ｍ）脂肪燃焼を促進する、
　ｎ）ミトコンドリアの活性化を促進する、
　ｏ）ストレス若しくは疲労感を軽減する、又は
　ｐ）便秘を解消する、
ための器具であって、バイオレットライトを通過させるガラス、めがねレンズ又はコンタクトレンズを含む、器具。
（付記３３）
　処置を必要とする対象において生体機能制御効果を生じさせるための方法であって、対象に対して特定波長の光を照射することを含む、方法。
（付記３４）
　前記駆動回路が、光源及び少なくとも1つのメモリに通信可能に接続された少なくとも1つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも1つのメモリとを含む、付記１～９のいずれか一項記載の装置。
（付記３５）
　光を発する少なくとも１つの光源と、
　前記光源を駆動する駆動回路と、
を有し、
　前記駆動回路は、光源及び少なくとも１つのメモリに通信可能に接続された少なくとも１つのプロセッサと、プロセッサが実行可能な命令を格納するための少なくとも１つのメモリとを含み、
　前記光源が、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光を発するように構成されている、
光刺激による生体機能制御装置。
（付記３６）
　命令が格納された非一時的（ｎｏｎ－ｔｒａｎｓｉｔｏｒｙ）なコンピュータ可読媒体であって、命令がプロセッサによって実行されると、以下のステップを実行することができる、コンピュータ可読媒体：
　特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備える装置に対して、
　前記制御部が、前記光源の点滅周波数を０Ｈｚ又は３０～７５Ｈｚの範囲において制御するように前記装置を作動させるステップ、並びに
　前記光源が、３５０～４００ｎｍの範囲の波長の光を生体に照射するように前記装置を作動させるステップ。
  (Appendix 1)
Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces a biological function control effect when applied to a living body. A biological function control device using stimulation.
(Appendix 2)
It has at least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is light of a specific wavelength that, when irradiated to a living body, produces an effect of promoting an increase in the amount of tear fluid. , A device that promotes increased tear volume by light stimulation.
(Appendix 3)
At least one light source that emits light, and a drive circuit that drives the light source, and the light emitted by the light source has a specific wavelength that improves sleep efficiency or sleep quality when irradiated to a living body. A device for improving sleep efficiency or sleep quality by light stimulation.
(Appendix 4)
At least one light source that emits light, and a drive circuit that drives the light source, and the light emitted by the light source has a specific wavelength that causes an effect of reducing or suppressing an increase in blood glucose concentration by irradiating a living body. A light-stimulated blood glucose level reduction or increase inhibitory device.
(Appendix 5)
Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that causes a body temperature lowering effect when irradiated to a living body. A device that promotes hypothermia through stimulation.
(Appendix 6)
At least one light source that emits light, and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces an effect of suppressing weight gain when applied to a living body. A device for suppressing weight gain by stimulation.
(Appendix 7)
At least one light source that emits light and a drive circuit that drives the light source, and the light emitted by the light source is light of a specific wavelength that causes a parasympathetic nerve activation effect when irradiated to a living body. Device for promoting parasympathetic nerve activation by light stimulation.
(Appendix 8)
At least one light source that emits light, and a drive circuit that drives the light source, wherein the light emitted by the light source has a specific wavelength that promotes an increase in cerebral blood flow and cerebral oxygen concentration when applied to a living body. A device for promoting cerebral blood flow and cerebral oxygen concentration increase by optical stimulation.
(Appendix 9)
Light comprising at least one light source that emits light and a drive circuit that drives the light source, wherein the light emitted by the light source is light of a specific wavelength that produces a biological function control effect when applied to a living body. Light environment improvement device by stimulation.
(Appendix 10)
10. The device according to any one of the clauses 1-9, wherein the light is violet light.
(Appendix 11)
11. The device according to any one of clauses 1-10, wherein said specific wavelength comprises 350-400 nm.
(Appendix 12)
12. The apparatus of Clause 11, wherein the specific wavelength comprises approximately 380 nm.
(Appendix 13)
13. The device according to any one of the appendices 1-12, wherein the flashing frequency of the light is 0 Hz or 30-70 Hz.
(Appendix 14)
14. The device according to clause 13, wherein the blinking frequency is 0 Hz or 35-60 Hz.
(Appendix 15)
15. The device of clause 14, wherein the blinking frequency is 0 Hz or about 40 Hz.
(Appendix 16)
16. The apparatus according to any one of appendices 1 to 15, wherein the light irradiation conditions include the irradiation time of the light source.
(Appendix 17)
17. The light source according to any one of Appendices 1 to 16, wherein the light source is spectacles with a light source or a spectacle frame, a desktop light source, a light source attached to a mobile terminal, a light source installed in front of or near the face, a portable light source, an indoor lighting, or a tabletop stand. device.
(Appendix 18)
18. The method of operating the device according to any one of appendices 1 to 17, wherein the device controls a light source that irradiates a living body with light of a specific wavelength at a constant light or a specific blinking frequency, and the blinking frequency of the light source. wherein the control unit controls the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz, and the light source irradiates the living body with light having a wavelength in the range of 350 to 400 nm. including, how it works.
(Appendix 19)
19. The method of operation of claim 18, wherein said specific wavelength is approximately 380 nm.
(Appendix 20)
20. The method of operation according to clause 18 or 19, wherein said particular blinking frequency is 0 Hz or about 40 Hz.
(Appendix 21)
Supplementary notes 18 to 18, wherein the control unit further comprises a function of controlling the time or period of irradiation with the light of the specific wavelength, and further comprising the step of controlling the irradiation time in the range of 10 seconds to 100 hours. 21. A method of operation according to any one of claims 20.
(Appendix 22)
22. The operation method according to any one of appendices 17 to 21, for a device comprising a light source that irradiates a living body with light of a specific wavelength at a constant light or a specific blinking frequency, and a control unit that controls the blinking frequency of the light source. computer program that causes the
(Appendix 23)
In a subject in need of treatment,
a) promoting increased tear volume,
b) improve sleep efficiency or sleep quality;
c) reduce or inhibit increase in blood glucose concentration,
d) promoting hypothermia,
e) suppress weight gain,
f) promoting parasympathetic activation, or g) promoting cerebral blood flow and cerebral oxygenation, comprising exposing a subject to light in the wavelength range of 350-400 nm at 0 Hz or 30- A method comprising irradiating a living body with a flickering frequency in the range of 75 Hz, whereby said effect is obtained in said living body receiving said light.
(Appendix 24)
Irradiate the living body with a violet light at a constant light or a specific blinking frequency,
a) for the prevention or treatment of corneal diseases,
b) for preventing or treating dry eye,
c) for the prevention or treatment of sleep disorders and related diseases;
d) to prevent or treat sleep disorders,
e) to combat jet lag,
f) to induce sleep,
g) to suppress drowsiness,
h) to prevent diabetes,
i) to prevent chronic kidney damage, arteriosclerosis, cerebral infarction, or gout,
j) to prevent obesity,
k) for preventing aging-related diseases,
l) to activate the metabolism,
m) to promote fat burning,
n) to promote mitochondrial activation,
o) to relieve stress or fatigue, or p) to relieve constipation,
A device comprising: a light source that emits the violet light; a light emission cycle control unit that makes the violet light a constant light or a specific blinking frequency; and a light emission time control unit that irradiates the violet light for a specific time or for a specific period. and a device used to obtain the above effect.
(Appendix 25)
Irradiate the living body with the constant light of the violet light,
a) prevent or treat corneal diseases,
b) prevent or treat dry eye,
c) prevent or treat sleep disorders and related diseases;
d) prevent or treat sleep disorders;
e) relieve jet lag,
f) induce sleep,
g) suppress drowsiness,
h) prevent diabetes,
i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout;
j) prevent obesity,
k) prevent aging-related diseases,
l) activate metabolism,
m) promote fat burning,
n) promotes mitochondrial activation;
o) reduce stress or fatigue, or p) relieve constipation,
A device comprising: a light source that emits the violet light; and a light emission time controller that irradiates the violet light for a specific time or for a specific period.
(Appendix 26)
At least one light source that emits light, and a driving circuit that drives the light source, wherein the light emitted by the light source irradiates a living body,
a) prevent or treat corneal diseases,
b) prevent or treat dry eye,
c) prevent or treat sleep disorders and related diseases;
d) prevent or treat sleep disorders;
e) relieve jet lag,
f) induce sleep,
g) suppress drowsiness,
h) prevent diabetes,
i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout;
j) prevent obesity,
k) prevent aging-related diseases,
l) activate metabolism,
m) promote fat burning,
n) promotes mitochondrial activation;
o) reduce stress or fatigue, or p) relieve constipation,
A photo-stimulated device that is a specific wavelength of light that produces an effect.
(Appendix 27)
a) prevent or treat corneal diseases,
b) prevent or treat dry eye,
c) prevent or treat sleep disorders and related diseases;
d) prevent or treat sleep disorders;
e) relieve jet lag,
f) induce sleep,
g) suppress drowsiness,
h) prevent diabetes,
i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout;
j) prevent obesity,
k) prevent aging-related diseases,
l) activate metabolism,
m) promote fat burning,
n) promotes mitochondrial activation;
o) reduce stress or fatigue, or p) relieve constipation,
A method of operating a device for use in a method for , the control unit controlling the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz; and the light source irradiating the living body with light having a wavelength in the range of 350 to 400 nm.
(Appendix 28)
A computer program for causing an apparatus comprising a light source for irradiating a living body with light of a specific wavelength at a constant light or at a specific blinking frequency and a controller for controlling the blinking frequency of the light source to execute the operation method of appendix 26.
(Appendix 29)
In a subject in need of treatment,
a) prevent or treat corneal diseases,
b) prevent or treat dry eye,
c) prevent or treat sleep disorders and related diseases;
d) prevent or treat sleep disorders;
e) relieve jet lag,
f) induce sleep,
g) suppress drowsiness,
h) prevent diabetes,
i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout;
j) prevent obesity,
k) prevent aging-related diseases,
l) activate metabolism,
m) promote fat burning,
n) promotes mitochondrial activation;
o) reduce stress or fatigue, or p) relieve constipation,
comprising the step of irradiating a subject with light having a wavelength in the range of 350-400 nm at a blinking frequency in the range of 0 Hz or 30-75 Hz, whereby said living body receiving said light A method in which the above effect is obtained.
(Appendix 30)
Devices for improving the light environment by photostimulation, including glasses, spectacle lenses or contact lenses that allow violet light to pass through.
(Appendix 31)
In a subject in need of treatment,
a) promoting increased tear volume,
b) improve sleep efficiency or sleep quality;
c) reduce or inhibit increase in blood glucose concentration,
d) promoting hypothermia,
e) suppress weight gain,
f) promoting parasympathetic activation, or g) devices for promoting cerebral blood flow and cerebral oxygenation, comprising glasses, spectacle lenses or contact lenses that allow violet light to pass through.
(Appendix 32)
In a subject in need of treatment,
a) prevent or treat corneal diseases,
b) prevent or treat dry eye,
c) prevent or treat sleep disorders and related diseases;
d) prevent or treat sleep disorders;
e) relieve jet lag,
f) induce sleep,
g) suppress drowsiness,
h) prevent diabetes,
i) prevent chronic kidney damage, arteriosclerosis, stroke, or gout;
j) prevent obesity,
k) prevent aging-related diseases,
l) activate metabolism,
m) promote fat burning,
n) promotes mitochondrial activation;
o) reduce stress or fatigue, or p) relieve constipation,
comprising glasses, spectacle lenses or contact lenses that allow violet light to pass through.
(Appendix 33)
A method for producing a biofunction-regulating effect in a subject in need of treatment, the method comprising irradiating the subject with light of a particular wavelength.
(Appendix 34)
10. Any of Clauses 1-9, wherein the drive circuitry includes at least one processor communicatively connected to a light source and at least one memory, and at least one memory for storing processor-executable instructions. A device according to claim 1.
(Appendix 35)
at least one light source that emits light;
a driving circuit for driving the light source;
has
the drive circuitry includes at least one processor communicatively connected to a light source and at least one memory; and at least one memory for storing processor-executable instructions;
The light source is configured to emit light of a specific wavelength that produces a biological function control effect by irradiating the living body.
Biofunction control device by optical stimulation.
(Appendix 36)
A non-transitory computer-readable medium having instructions stored thereon that, when the instructions are executed by a processor, are capable of performing the following steps:
A device comprising a light source that irradiates a living body with light of a specific wavelength at a constant light or a specific blinking frequency, and a control unit that controls the blinking frequency of the light source,
the control unit operating the device to control the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz; activating the device to.

Claims (23)

  1. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、
    光刺激による生体機能制御装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that produces a biological function control effect by irradiating the living body.
    Biofunction control device by optical stimulation.
  2. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって涙液量増加促進効果を生じさせる特定波長の光である、
    光刺激による涙液量増加促進装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that produces an effect of promoting tear volume increase by irradiating the living body.
    A device that promotes increased tear volume by light stimulation.
  3. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって睡眠効率又は睡眠の質の改善効果を生じさせる特定波長の光である、
    光刺激による睡眠効率又は睡眠の質の改善装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that produces an effect of improving sleep efficiency or sleep quality by irradiating a living body.
    An apparatus for improving sleep efficiency or sleep quality by light stimulation.
  4. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって血中グルコース濃度低減又は増加抑制効果を生じさせる特定波長の光である、
    光刺激による血中グルコース濃度低減又は増加抑制装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that causes an effect of suppressing blood glucose concentration reduction or increase by irradiating the living body.
    A blood glucose concentration reduction or increase suppression device by light stimulation.
  5. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって体温低下促進効果を生じさせる特定波長の光である、
    光刺激による体温低下促進装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that causes a body temperature lowering effect by irradiating the living body.
    A device that promotes hypothermia by light stimulation.
  6. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって体重増加抑制効果を生じさせる特定波長の光である、
    光刺激による体重増加抑制装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that produces an effect of suppressing weight gain by irradiating a living body.
    A device for suppressing weight gain by light stimulation.
  7. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって副交感神経活性化効果を生じさせる特定波長の光である、
    光刺激による副交感神経活性化促進装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that causes a parasympathetic nerve activation effect by irradiating the living body.
    Device for promoting parasympathetic nerve activation by light stimulation.
  8. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって脳血流及び脳酸素濃度増加促進効果を生じさせる特定波長の光である、
    光刺激による脳血流及び脳酸素濃度増加促進装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that causes an increase in cerebral blood flow and cerebral oxygen concentration by irradiating the living body.
    A device for increasing cerebral blood flow and cerebral oxygen concentration by light stimulation.
  9. 　光を発する少なくとも１つの光源と、
    　前記光源を駆動する駆動回路と、
    を有し、
    　前記光源が発する光は、生体へ照射することによって生体機能制御効果を生じさせる特定波長の光である、
    光刺激による光環境改善装置。     at least one light source that emits light;
    a driving circuit for driving the light source;
    has
    The light emitted by the light source is light of a specific wavelength that produces a biological function control effect by irradiating the living body.
    Light environment improvement device by light stimulation.
  10. 　前記光はバイオレットライトである、請求項１～９のいずれか一項記載の装置。 The device according to any one of claims 1 to 9, wherein said light is violet light.
  11. 　前記特定波長は３５０～４００ｎｍを含む、請求項１～１０のいずれか一項記載の装置。 The device according to any one of claims 1 to 10, wherein said specific wavelength includes 350 to 400 nm.
  12. 　前記特定波長は約３８０ｎｍを含む、請求項１１記載の装置。 12. The apparatus of claim 11, wherein said specific wavelength comprises approximately 380 nm.
  13. 　光の点滅周波数が０Ｈｚ又は３０～７０Ｈｚである、請求項１～１２のいずれか１項記載の装置。 The device according to any one of claims 1 to 12, wherein the flashing frequency of the light is 0 Hz or 30 to 70 Hz.
  14. 　前記点滅周波数は０Ｈｚ又は３５～６０Ｈｚである、請求項１３記載の装置。 The device according to claim 13, wherein said blinking frequency is 0 Hz or 35-60 Hz.
  15. 　前記点滅周波数は０Ｈｚ又は約４０Ｈｚである、請求項１４記載の装置。 15. The device of claim 14, wherein the flashing frequency is 0 Hz or about 40 Hz.
  16. 　光の照射条件が、前記光源の照射時間を含む、請求項１～１５のいずれか１項記載の装置。 The apparatus according to any one of claims 1 to 15, wherein the light irradiation conditions include the irradiation time of the light source.
  17. 　前記光源は、光源付きめがね若しくはめがねフレーム、卓上光源、移動体端末装着光源、顔前又は近傍設置型光源、携帯光源、室内照明、又は卓上スタンドである、請求項１～１６のいずれか１項記載の装置。 17. Any one of claims 1 to 16, wherein the light source is spectacles with a light source or a spectacle frame, desktop light source, mobile terminal-mounted light source, face-mounted light source or near-face type light source, portable light source, indoor lighting, or desktop stand. Apparatus as described.
  18. 　請求項１～１７のいずれか一項記載の装置の作動方法であって、前記装置は、特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備え、前記制御部が、前記光源の点滅周波数を０Ｈｚ又は３０～７５Ｈｚの範囲において制御する段階、前記光源が、３５０～４００ｎｍの範囲の波長の光を生体に照射する段階を含む、作動方法。 18. The method of operating the device according to any one of claims 1 to 17, wherein the device comprises a light source that irradiates a living body with light of a specific wavelength at a constant light or a specific blinking frequency, and a blinking frequency of the light source. a controller for controlling, wherein the controller controls the blinking frequency of the light source in the range of 0 Hz or 30 to 75 Hz; and the light source irradiates the living body with light having a wavelength in the range of 350 to 400 nm. method of operation, including
  19. 　前記特定波長が、約３８０ｎｍである、請求項１８記載の作動方法。 The method of operation according to claim 18, wherein said specific wavelength is about 380 nm.
  20. 　前記特定の点滅周波数が、０Ｈｚ又は約４０Ｈｚである、請求項１８または１９記載の作動方法。 20. The method of operation according to claim 18 or 19, wherein said specific blinking frequency is 0 Hz or about 40 Hz.
  21. 　前記制御部が、前記特定波長の光を照射する時間又は期間を制御する機能をさらに備え、前記制御部が、照射時間を１０秒～１００時間の範囲で制御する段階をさらに含む、請求項１８～２０のいずれか一項記載の作動方法。 18. The control unit further comprises a function of controlling a time or period of irradiation with the light of the specific wavelength, and further comprising a step of controlling the irradiation time within a range of 10 seconds to 100 hours. 21. A method of operation according to any one of claims 1 to 20.
  22. 　特定波長の光を常灯又は特定の点滅周波数で生体に照射する光源と、前記光源の点滅周波数を制御する制御部とを備えた装置に請求項１７～２１のいずれか一項に記載の作動方法を実行させるコンピュータプログラム。 The operation according to any one of claims 17 to 21 to a device comprising a light source that irradiates a living body with light of a specific wavelength at a constant light or a specific blinking frequency, and a control unit that controls the blinking frequency of the light source. A computer program that carries out a method.
  23. 　処置を必要とする対象において、
    　ａ）涙液量の増加を促進する、
    　ｂ）睡眠効率又は睡眠の質を改善する、
    　ｃ）血中グルコース濃度を低減又は増加抑制する、
    　ｄ）体温低下を促進する、
    　ｅ）体重増加を抑制する、
    　ｆ）副交感神経の活性化を促進する、又は
    　ｇ）脳血流及び脳酸素濃度増加を促進する
    ための方法であって、対象に対して３５０～４００ｎｍの範囲の波長の光を０Ｈｚ又は３０～７５Ｈｚの範囲の点滅周波数で生体に照射する段階を含み、それにより、前記光を受けた前記生体において上記効果が得られる、方法。
     
          In a subject in need of treatment,
    a) promoting increased tear volume,
    b) improve sleep efficiency or sleep quality;
    c) reduce or inhibit increase in blood glucose concentration,
    d) promoting hypothermia,
    e) suppress weight gain,
    f) promoting parasympathetic activation, or g) promoting cerebral blood flow and cerebral oxygenation, comprising exposing a subject to light in the wavelength range of 350-400 nm at 0 Hz or 30- A method comprising irradiating a living body with a flickering frequency in the range of 75 Hz, whereby said effect is obtained in said living body receiving said light.
PCT/JP2022/012620 2021-03-19 2022-03-18 Device for controlling biometric function via light stimulation and operation method thereof WO2022196798A1 (en)

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