WO2022186122A1

WO2022186122A1 - Blood bag system and blood treatment method

Info

Publication number: WO2022186122A1
Application number: PCT/JP2022/008229
Authority: WO
Inventors: 武田典彦; 川口悟司
Original assignee: テルモ株式会社
Priority date: 2021-03-01
Filing date: 2022-02-28
Publication date: 2022-09-09
Also published as: JPWO2022186122A1

Abstract

This blood bag system (10) and blood treatment method has a first bag (22) for containing blood, a second bag (24) for containing a blood component obtained by centrifugally separating the blood in the first bag, a third bag (26) in which an additive solution is contained, a first tube (34) connected to the first bag, a second tube (36) connected to the second bag, a third tube (38) connected to the third bag, and a branch part (32) linking the above elements. The second tube (36) is provided with a pressure opening/closing valve (100) that opens when the pressure reaches or exceeds a prescribed opening pressure.

Description

Blood bag system and blood processing method

The present invention relates to a blood bag system used for separating blood components and a blood processing method.

Japanese Patent Application Laid-Open No. 2016-106012 discloses a first bag (parent bag) for containing blood and a second bag for containing blood components obtained by centrifuging the blood in the first bag ( A blood bag system is disclosed that includes a secondary bag) and a third bag (medicine bag) containing an additive solution. The blood bag system has a first tube connected to the first bag, a second tube connected to the second bag, and a third tube connected to the third bag. are connected to each other by branches (Y-connectors).

The blood bag system is set in a centrifugal separation transfer device by a user such as a medical professional, centrifuges blood to generate blood components, and separates a liquid containing blood components between the first to third bags. Configure the transfer centrifuge system. In the centrifugation system, after the blood components are transferred from the first bag to the second bag, the user closes the flow path of the second tube with the first clamp and closes the flow path of the third tube with the second clamp. be done. In this state, the user removes the blood bag system from the centrifugal transfer device, suspends it on the suspension base, and removes the second clamp from the third tube to transfer the additive solution from the third bag to the first bag. do.

The conventional blood bag system requires the user to operate two clamps, and the operation of the clamps is complicated, and there is a risk of erroneous operations such as removing the wrong clamp.

The present invention has been made in view of the above problems, and an object thereof is to provide a blood bag system and a blood processing method that facilitate clamp operation and prevent erroneous clamp operation.

One aspect of the following disclosure is a first bag for containing blood, a second bag for containing blood components obtained by centrifuging the blood in the first bag, and an additive solution containing a third bag connected to the first bag, a first tube connected to the first bag, a second tube connected to the second bag, a third tube connected to the third bag, and the first tube , a branch connecting the second tube and the third tube, and a flow path passing through the second tube or a flow path toward the second tube inside the branch, and closes the flow path and a pressure opening/closing valve that opens the flow path when the pressure in the flow path reaches or exceeds a predetermined opening pressure.

Another aspect is a method of processing blood using the blood bag system of the above aspect, comprising the steps of: separating blood in said first bag into blood components under the action of centrifugal force; transferring part of the blood components to the second bag by applying pressure to open the pressure on-off valve; and transferring the added solution in the third bag to the first bag by gravity flow. and a method for treating blood.

According to the blood bag system and the blood processing method of the above viewpoint, one of the conventional two clamps is a pressure opening/closing valve, so that the number of clamps can be reduced to only one. It is possible to prevent erroneous operation of the clamp due to

1 is an explanatory diagram showing the overall configuration of a blood bag system and a centrifugal separation system according to a first embodiment; FIG. FIG. 4 is a plan view showing a unit set area of the centrifugal transfer device; FIG. 4 is a perspective view showing a state in which the branching portion of the blood bag system is set in the holder of the centrifugal transfer device; It is a sectional view of a pressure on-off valve. 5 is a cutaway perspective view of the valve body of the pressure on-off valve of FIG. 4; FIG. FIG. 5 is a plan view showing a modification of the slit of the pressure on-off valve of FIG. 4; 2 is a flow chart showing a blood processing method using the blood bag system of FIG. 1; FIG. 8A is an explanatory diagram showing the flow of blood components in the blood bag system during centrifugation, and FIG. 8B is an explanatory diagram showing the flow of the additive solution during gravity flow transfer of the additive solution. It is sectional drawing which shows the modification (1) of the application site|part of a pressure on-off valve. It is sectional drawing which shows the modification (2) of the application site|part of a pressure on-off valve.

Hereinafter, preferred embodiments of the present invention will be cited and described in detail with reference to the accompanying drawings.

(First embodiment)
A blood bag system 10 according to the first embodiment of the present invention is set in a centrifugal transfer device 12 as shown in FIG. 1 by a user such as a medical worker. The centrifugal transfer device 12 centrifuges the blood in the blood bag system 10 to produce a plurality of types of blood components, and transfers the produced blood components to an appropriate bag 20 for storage. A configuration including the blood bag system 10 and the centrifugal transfer device 12 is hereinafter referred to as a centrifugal separation system 14 .

The blood bag system 10 includes a pretreatment unit (not shown) used for blood collection before centrifugation, a separation processing unit 16 for generating blood components by centrifugation and individually storing them, and a pretreatment unit and separation processing unit 16. and a relay tube 18 connecting the . Prior to centrifugation, the separation processing section 16 is set in the centrifugal transfer device 12 in the state shown in FIG.

The pretreatment unit of the blood bag system 10 collects whole blood from a blood donor and removes blood components such as leukocytes from the whole blood. Therefore, the pretreatment unit has a blood collection needle, a blood collection bag, an initial blood flow bag, a filter (for example, a leukocyte removal filter) and the like (not shown), and is configured by connecting each member with a plurality of tubes 30 . Specifically, the preprocessing unit stores the first blood of the donor's whole blood collected through the blood collection needle in the initial blood flow bag, and then stores the remaining blood in the blood collection bag. Further, the preprocessing unit passes the whole blood stored in the blood collection bag through a filter to remove leukocytes in the filter. The blood from which leukocytes have been removed is transferred to the separation processing section 16 connected to the filter via the relay tube 18 .

The separation processing section 16 of the blood bag system 10 has a plurality of bags 20 (blood bag 22, PPP bag 24, and drug solution bag 26) and is configured by connecting each bag 20 with a plurality of tubes 30.

The blood bag 22 is directly connected to the relay tube 18 connected to the pretreatment section in the state where the blood bag system 10 is provided as a product. The blood bag 22 is a first bag having a first storage space 22a that stores blood from which leukocytes have been removed by passing through a filter during blood collection. This blood bag 22 is set in the centrifugal separation transfer device 12 and centrifugal force is applied by the operation of the centrifugal separation transfer device 12 . As a result, the blood removed from the blood bag 22 is centrifuged into blood components such as platelet poor plasma (PPP) and red blood cells (RBC) having different specific gravities. After centrifugation, the blood bag 22 stores only the remaining RBCs by transferring the PPP under the operation of the centrifugal transfer device 12 .

The PPP bag 24 is a second bag (plasma bag) that stores the PPP in the second storage space 24a as the PPP is supplied from the blood bag 22. On the other hand, the chemical solution bag 26 is a third bag in which a red blood cell preservation solution (hereinafter referred to as an additive solution) such as MAP solution, SAGM solution, OPTISOL, etc. is stored in advance in the third storage space 26a.

In addition, before the separation processing unit 16 is set in the centrifugal transfer device 12, the relay tubes 18 are sealed at predetermined intervals to form segment tubes 28.

A plurality of tubes 30 of the separation processing unit 16 are branched into a plurality of via branch connectors 32 (Y-shaped connectors: branch portions). Specifically, the plurality of tubes 30 includes a first tube 34 connecting the blood bag 22 and the branch connector 32, a second tube 36 connecting the PPP bag 24 and the branch connector 32, and a drug solution bag 26 and the branch connector 32. A third tube 38 is included. The first tube 34 has a first flow path 34a, the second tube 36 has a second flow path 36a, and the third tube 38 has a third flow path 38a.

Also, the branch connector 32 has a first port 32a to which the first tube 34 is connected, a second port 32b to which the second tube 36 is connected, and a third port 32c to which the third tube 38 is connected, The first port 32a, the second port 32b, and the third port 32c are integrally molded. The first port 32a, the second port 32b, and the third port 32c communicate with each other through an internal channel (not shown), thereby allowing the channels of the first tube 34, the second tube 36, and the third tube 38 to flow. communicate with each other.

At the end of the first tube 34 on the blood bag 22 side, there is provided a sealing member 40 that can be broken and the internal flow path is opened by the user's breaking operation. Similarly, a breakable sealing member 42 is provided at the end of the third tube 38 on the drug solution bag 26 side. The sealing

members

40 and 42 block the first flow path 34a and the third flow path 38a, respectively, until the breaking operation is performed, and the blood in the blood bag 22 and the additive solution in the drug solution bag 26 are separated from the other bags 20. prevent it from being transferred to

The blood bag system 10 also includes a pressure on-off valve 100 provided on the second tube 36 near the branch connector 32 and a clamp 37 attached to the third tube 38 . The clamp 37 is configured to open and close based on the user's operation and switch the third channel 38a of the third tube 38 between an open state and a closed state. The pressure on-off valve 100 is closed in the initial state and closes the second flow path 36 a of the second tube 36 . When a fluid pressure equal to or higher than the opening pressure acts on the pressure on-off valve 100, the second flow path 36a is opened. Details of the pressure on-off valve 100 will be described later.

On the other hand, the centrifugal transfer device 12 in which the separation processing unit 16 of the blood bag system 10 is set includes a box-shaped base 44, a lid 46 capable of opening and closing the upper surface of the base 44, and a centrifugal drum 48 provided on the base 44. Prepare. The base 44 of the centrifugal transfer device 12 includes a motor (not shown) for rotating the centrifugal drum 48, a control unit 50 for controlling the operation of the centrifugal transfer device 12, and an operation display unit for user confirmation and operation. 52 are provided.

The centrifugal drum 48 has a plurality (six) of unit setting areas 54 in which the separation processing units 16 can be set. One unit set area 54 has a height longer than the longitudinal length of the bag 20 and is set within a range of 60° with respect to the center of rotation of the centrifugal drum 48 . In other words, the six unit set areas 54 are arranged circumferentially without gaps to form the centrifugal drum 48, which is an annular structure.

As shown in FIG. 2, the unit set area 54 includes a blood bag pocket 56 containing the blood bag 22, a PPP bag pocket 58 containing the PPP bag 24, and a medical solution bag pocket 60 containing the medical solution bag 26. It is provided at a radially outer position of the centrifugal drum 48 .

The blood bag pocket 56 is provided in the circumferential central portion of the unit set area 54 and has a volume larger than that of the PPP bag pocket 58 and the drug solution bag pocket 60 . The PPP bag pocket 58 and the drug solution bag pocket 60 are provided side by side in the circumferential direction outside the blood bag pocket 56 in the radial direction.

In addition, the upper surface 54a of the unit set area 54 is configured to arrange and hold the plurality of tubes 30 of the blood bag system 10. A portion of the first tube 34 and the segment tube 28 are arranged in a central region 54a1 radially inside the blood bag pocket 56 on the upper surface 54a. A lid 62 for opening and closing the opening of the blood bag pocket 56 is provided in the central region 54a1. Further, at the arrangement position of the first tube 34 closed by the lid 62, a part of the breaking portion 64 that breaks the sealing member 40 and a sensor 66 that detects the state of the blood flowing through the first tube 34 are provided. It is

A portion of the first tube 34, a portion of the branch connector 32, a second tube 36 and a portion of the third tube 38 passing through the central region 54a1 are arranged in the left region 54a2 of the upper surface 54a. The left area 54a2 includes a holder 150 for holding the branch connector 32, a PPP clamp 70 for opening and closing the second flow path 36a of the second tube 36, and a chemical solution for opening and closing the third flow path 38a of the third tube 38. A clamp 72 is provided.

A right region 54a3 of the upper surface 54a is provided with a segment pocket 74 for accommodating a plurality of closed tubes 28a (see FIG. 1) of the segment tube 28. As shown in FIG.

Furthermore, a tube holding portion 76 that protrudes upward from the upper surface 54a is provided radially outward of the PPP bag pocket 58 and the chemical solution bag pocket 60 of the unit set area 54 . The tube holding portion 76 has a guide groove portion 78 in which the second tube 36 is arranged.

The unit set area 54 also includes a slider 82 radially inside the blood bag pocket 56 for pressing the blood bag 22 after centrifugation. The slider 82 advances and retreats along the radial direction of the centrifugal drum 48 under the control of the controller 50 (see FIG. 1).

In the unit set area 54 , the user puts the blood bag 22 storing the removed blood into the blood bag pocket 56 , the empty PPP bag 24 into the PPP bag pocket 58 , and the drug solution bag 26 storing the drug solution into the drug solution bag pocket 60 . are accommodated in each. The unit set area 54 centrifuges the removed blood in the blood bag 22 by rotating the centrifugal drum 48 , and advances the slider 82 to press the blood bag 22 after the centrifugal separation. As a result, the PPP produced in the blood bag 22 by centrifugation is transferred to the PPP bag 24, and the RBC remains in the blood bag 22 after the PPP is transferred. After transfer of the PPP, the blood bag system 10 is removed from the centrifuge transfer device 12 by the user.

Next, the pressure on-off valve 100 of the blood bag system 10 according to this embodiment will be described with reference to FIGS. 3 to 6. FIG.

As described above, the pressure on-off valve 100 is attached to the second tube 36 of the blood bag system 10 and closes the second flow path 36a. Furthermore, the pressure on-off valve 100 is configured to be opened by the fluid pressure when the blood bag 22 is pressurized by the centrifugal transfer device 12 . The pressure on-off valve 100 is also configured to close again when the fluid pressure drops.

Specifically, as shown in FIG. 4, the pressure on-off valve 100 includes a cylindrical housing 84 made of resin material or metal material. A first connection port 86 and a second connection port 88 to which the second tube 36 is connected are provided at one end and the other end of the housing 84 of the pressure on-off valve 100 . A hollow portion 84 a is formed inside the housing 84 . A valve body 90 is arranged in the hollow portion 84a. The valve body 90 is made of a soft elastic material such as rubber or elastomer.

As shown in FIG. 5, the valve body 90 includes a disk-shaped valve body 92 and a support portion 94 projecting from the peripheral edge portion of the valve body 92 to one side (axial direction) in the thickness direction of the valve body 92 . have. The support portion 94 is formed to protrude in the shape of a circular wall along the peripheral portion of the valve body 92 . As shown in FIG. 4, the support portion 94 is in close contact with the inner wall of the housing 84 and prevents the valve body 90 from being displaced even when pressure is applied.

The valve body 92 is formed in the same shape as the cross section of the hollow portion 84a, and divides the hollow portion 84a into an area on the first connection port 86 side and an area on the second connection port 88 side in an air-tight and liquid-tight manner. As shown in FIG. 5 , a slit 96 is formed in the central portion of the valve body 92 and is a linear cut extending through the valve body 92 in the thickness direction. The slit 96 is formed in a linear shape passing through the central axis of the disk-shaped valve body 92 when viewed from the front.

The slit 96 is tightly closed when no pressure is applied, and prevents the passage of fluid. The valve main body 92 is elastically deformed when pressure is applied, and a gap is generated in the slit 96 so that the valve body 92 can be deformed into an open state in which fluid is allowed to pass. The pressure (opening pressure) when the valve body 90 is opened can be appropriately set according to the thickness of the valve body 92 . As the thickness of the valve body 92 increases, the opening pressure increases, and as the thickness of the valve body 92 decreases, the opening pressure decreases.

The opening pressure of the valve body 90 is preferably set to at least a value that does not open due to the pressure when the added solution in the drug solution bag 26 is transferred to the blood bag 22 under gravity flow. As a result of investigations by the inventors of the present application, the pressure generated when the chemical solution bag 26 naturally flows down varies depending on the difference in height between the chemical solution bag 26 and the valve body 90, but is approximately 1.7 kPa. The pressure generated when the drug solution bag 26 was lightly gripped was about 3.3 kPa, and the pressure generated when the drug solution bag 26 was gripped strongly was about 8 kPa.

Therefore, from the viewpoint of preventing unintended opening during handling, the opening pressure should be higher than 1.7 kPa. ) is preferred. However, if the opening pressure of the valve body 90 is too high, the pressure of the blood bag 22 of the centrifugal separation transfer device 12 prevents the valve body 90 from opening. is preferably not more than the upper limit of (for example, 200 kPa). Further, the PPP bag 24 is operated by the user to remove air bubbles after the plasma component is transferred. If the opening pressure of the valve body 90 is too high, it becomes difficult for the user to remove air bubbles. Therefore, the upper limit of the opening pressure is more preferably equal to or less than the pressure (eg, 8 kPa) that can be generated by gripping the PPP bag 24 strongly. is preferably A pressure of 3.3 kPa to 6 kPa is more preferable from the viewpoint of preventing mixing of the plasma component and the additive solution and removing air.

The number of slits 96 is not limited to one, and a plurality of slits 96 may be provided radially around the central axis as shown in the modified example of FIG. The above pressure on-off valve 100 is connected to the middle of the second tube 36 as shown in FIG. Although not particularly limited, the pressure on-off valve 100 can be connected to the second tube 36 near the branch connector 32 .

As shown in FIG. 3 , the holder 150 has a connector holding portion 152 holding the branch connector 32 and a clamp holding portion 154 holding the clamp 37 . The pressure on-off valve 100 is arranged near the holder 150 together with the branch connector 32 when the blood bag system 10 is set on the centrifugal transfer device 12 .

The connector holding portion 152 is formed in a columnar shape, has a Y-shaped holding groove 152a cut from the upper end portion to a predetermined depth, and is configured so that the branch connector 32 can be fitted from the outside.

In manufacturing the above-described pressure on-off valve 100, the valve body 92 is formed by injection molding or the like separately from the bag 20 and the tube 30. By arranging the valve body 92 in the housing 84 and connecting the first connection port 86 and the second connection port 88, the pressure on-off valve 100 is manufactured. When assembling the blood bag system 10 , the pressure on/off valve 100 is connected to the second tube 36 and the clamp 37 is attached to the third tube 38 . The second tube 36 and the third tube 38 are then secured to the branch connector 32 . Thereby, the blood bag system 10 having the pressure on-off valve 100 is formed.

The blood bag system 10 according to the first embodiment is basically configured as described above, and the operation thereof will be described below together with the blood processing method.

The blood processing method using the blood bag system 10 includes a blood collection step (step S1), a leukocyte removal step (step S2), an apparatus setting step (step S3), a centrifugation step (step S4), a plasma component transfer step (step S5), an apparatus extraction step (step S6), a suspension step (step S7), an additive solution injection step (step S8), and a seal separation step (step S9). be done.

In the blood collection step (step S1), the user collects the donor's whole blood using the blood collection needle of the preprocessing unit (not shown) and stores it in a blood collection bag. Next, in the leukocyte removal step (step S2), the user moves whole blood from the blood collection bag to the blood bag 22. FIG. At this time, the whole blood passes through the filter, and the blood bag 22 stores the removed blood from which leukocytes have been removed from the whole blood.

In order to centrifuge the removed blood, the user separates the separation processing section 16 of the blood bag system 10 from the preprocessing section and sets it on the centrifugal transfer device 12 in the device setting step (step S3). As shown in FIG. 2, the user stores the blood bag 22 in the blood bag pocket 56 of the unit setting area 54, and along the predetermined path on the upper surface 54a of the unit setting area 54, the first tube 34 and the second tube. 36, and the third tube 38 are set. The first tube 34 is routed along a predetermined path in the central area 54a1 and then directed toward the left area 54a2. Further, the user manages the first tube 34, the second tube 36, and the third tube 38 in the left area 54a2, and holds the branch connector 32 and the clamp 37 in the holder 150.

The second tube 36 extends outward in the centrifugal direction from the branch connector 32 through the left area 54 a 2 and is arranged to pass through the PPP clamp 70 . Further, the second tube 36 is accommodated in the guide groove portion 78 of the tube holding portion 76 radially outside the medical solution bag pocket 60 . The third tube 38 also extends outward in the centrifugal direction from the branch connector 32 through the left region 54 a 2 and is arranged to pass through the drug solution clamp 72 . Then, the user stores the PPP bag 24 connected to the second tube 36 in the PPP bag pocket 58 and stores the drug solution bag 26 connected to the third tube 38 in the drug solution bag pocket 60 . This completes the setting of the blood bag system 10 to the centrifugal transfer device 12 .

As shown in FIG. 3, the user attaches the branch connector 32 to the connector holding portion 152 of the holder 150, and at the same time inserts the clamp 37 into the arrangement space 162 between the holding plate 160 and the opposing wall 161 of the holder 150. do. After the device setting step (step S3), the pressure on-off valve 100 closes the second flow path 36a of the second tube 36. As shown in FIG.

Thereafter, in the centrifugal separation step (step S4), the centrifugal transfer device 12 rotates the centrifugal drum 48 under the control of the control unit 50, thereby separating the removed blood from the blood bag 22 into PPP, RBC, etc. having different specific gravities. Centrifuge into blood components. During centrifugation, the second tube 36 and the third tube 38 are closed by the PPP clamp 70 and the drug solution clamp 72 (see FIG. 2 for both), thereby suppressing the flow of blood components.

In addition, in the plasma component transfer step (step S5), the centrifugal transfer device 12 releases only the PPP clamp 70 and presses the blood bag 22 with the slider 82 . As a result, as shown in FIG. 8A, the pressure on-off valve 100 provided on the second tube 36 is opened. The PPP in the blood bag 22 then flows through the first tube 34 , the branch connector 32 and the second tube 36 in order and flows into the PPP bag 24 .

After the plasma component transfer step (step S5), the pressure on-off valve 100 is closed as the pressure in the second channel 36a decreases. Therefore, the second flow path 36a and the third flow path 38a return to the blocked state.

7, the centrifugal transfer device 12 retracts the slider 82 and opens the drug solution clamp 72 (see FIG. 2) to centrifuge the blood bag system 10. It is made separable from the transfer device 12 . The user closes the third channel 38 a of the third tube 38 with the clamp 37 . After that, the user takes out the blood bag system 10 . Then, in the suspending step (step S7), the user suspends the drug solution bag 26 on a stand (not shown) and further arranges the blood bag 22 below the drug solution bag 26 in the direction of gravity.

Next, in the additive solution injection step (step S8), the user opens the third tube 38 and breaks the sealing member 42, so that the additive solution in the drug solution bag 26 is poured into the blood as shown in FIG. 8B. Supply bag 22 . At this time, the user opens the third channel 38 a by deforming the clamp 37 . As a result, the added solution in the drug solution bag 26 is injected into the blood bag 22 through the third tube 38 and the first tube 34 . The pressure on/off valve 100 of the second tube 36 receives a pressure corresponding to the difference in height from the liquid medicine bag 26, but since it is lower than the opening pressure of the pressure on/off valve 100, the pressure on/off valve 100 is kept closed. be Therefore, according to this embodiment, it is possible to prevent the additive solution from entering the PPP bag 24 without providing the clamp 37 on the second tube 36 .

In the seal separation step (step S9) after the additive solution injection step (step S8), the user seals and cuts the first tube 34 at an appropriate position. As a result, the blood bag 22 is separated from the blood bag system 10 with the RBCs containing the added solution stored therein. Similarly, the user seals and cuts the PPP bag 24 side of the pressure shut-off valve 100 in the second tube 36 . This separates the PPP bag 24 from the blood bag system 10 with the PPP stored therein. The remaining blood bag system 10 including the pressure on-off valve 100 is discarded as appropriate.

It should be noted that the present invention is not limited to the above embodiments, and various modifications are possible in line with the gist of the invention. For example, as shown in FIG. 9, like the pressure on-off valve 100 of the blood bag system 10, the valve body 92 is arranged in the second flow path 36a of the second tube 36A, and the pressure on-off valve 100 is connected to the second tube 36A. may be integrated with

Further, for example, like the pressure on-off valve 100 shown in FIG. 10, the valve body 92 may be arranged inside the branch connector 32A, and the pressure on-off valve 100 may be integrated with the branch connector 32A.

The blood bag system 10 of this embodiment has the following effects.

The blood bag system 10 of this embodiment includes a first bag (for example, a blood bag 22) for containing blood, and a first bag for containing blood components obtained by centrifuging the blood in the first bag. 2 bags (for example, PPP bag 24), a third bag (for example, drug solution bag 26) containing an additive solution, a first tube 34 connected to the first bag, and a second bag connected to the second bag a second tube 36, a third tube 38 connected to a third bag, a branch portion (for example, a branch connector 32) connecting the first tube 34, the second tube 36 and the third tube 38, and the second tube 36 provided on the flow path (for example, the second flow path 36a) passing through or on the flow path toward the second tube 36 inside the branch, closing the flow path and increasing the pressure in the flow path to a predetermined opening pressure or higher Then, it is provided with a pressure on-off valve 100 that opens the flow path.

According to the above configuration, only one of the second tube 36 and the third tube 38 is required for the manual clamp 37, which eliminates the need to open and close the two clamps, improving user operability. In addition, since the user can concentrate on opening and closing one clamp 37, it is less likely that the clamp 37 will be erroneously operated.

In the blood bag system 10 described above, the pressure on-off valve 100 may be provided on the flow path passing through the third tube 38 or on the flow path toward the third tube 38 at the branch.

In the blood bag system 10 described above, the pressure on-off valve 100 is provided in the second tube 36, and the opening pressure of the pressure on-off valve 100 is the pressure of the additive solution that acts due to the drop between the third bag and the pressure on-off valve 100. can be higher than According to this configuration, in the blood bag system 10, the pressure opening/closing valve 100 is kept closed during the operation of injecting the additive solution from the third bag to the first bag, which is performed after the centrifugation step. , the addition solution can be prevented from flowing into the second tube 36 side. That is, it becomes unnecessary to attach the clamp 37 to the second tube 36 . This improves workability for the user.

In the blood bag system 10 described above, the opening pressure of the pressure on-off valve 100 may be 3.3 kPa or more. By configuring in this way, it is possible to effectively prevent the additive solution from being mixed into the second bag.

In the blood bag system 10 described above, the opening pressure of the pressure on-off valve 100 may be 200 kPa or less. With this configuration, the pressure opening/closing valve 100 is reliably opened when the blood components are transferred from the first bag to the second bag, so that the blood components can be reliably transferred.

In the blood bag system 10 described above, the pressure on-off valve 100 may be provided inside the branch. This configuration simplifies the configuration of the device and improves the handleability.

In the blood bag system 10 described above, the pressure on-off valve 100 may be provided inside the second tube 36 or the third tube 38 . This configuration simplifies the configuration of the device and improves the handleability.

In the blood bag system 10 described above, the pressure on-off valve 100 includes a plate-like (for example, disk-like) valve body 92 that closes the flow path, a support portion 94 that contacts the wall surface of the flow path, and a valve body 92. and a slit 96 passing through the central axis and through the valve body 92 in the thickness direction.

In the blood bag system 10 described above, a plurality of slits 96 may be radially provided.

In the blood bag system 10 described above, the axial thickness of the channel of the valve body 92 may be thinner than the axial thickness of the channel of the support portion 94 . According to this configuration, the valve body 92 can be deformed and opened and closed according to the pressure.

In the blood bag system 10 described above, the pressure on-off valve 100 may be made of rubber or elastomer.

The blood processing method of the present embodiment is a method of processing blood using the above-described blood bag system 10, comprising the step of separating the blood in the first bag into blood components under the action of centrifugal force; by pressurizing to open the pressure on-off valve 100 to transfer a portion of the blood components to the second bag; and transferring the additive solution in the third bag to the first bag by gravity flow. .

According to the blood processing method described above, the user can concentrate on opening and closing one clamp 37, thereby preventing erroneous opening and closing.

In the above blood processing method, after the step of separating the blood in the first bag into blood components under the action of the centrifugal force, closing the third tube with a clamp; and pressurizing the first bag. removing the clamp from the third tube after releasing the .

Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above embodiments, and it goes without saying that various modifications can be made without departing from the scope of the present invention. stomach.

Claims

a first bag for containing blood;
a second bag for containing blood components obtained by centrifuging the blood in the first bag;
a third bag containing an additive solution;
a first tube connected to the first bag;
a second tube connected to the second bag;
a third tube connected to the third bag;
a branching portion that connects the first tube, the second tube, and the third tube;
It is provided on the flow path passing through the second tube or on the flow path toward the second tube inside the branch portion, and closes the flow path, and when the pressure in the flow path reaches a predetermined opening pressure or higher, the a pressure on-off valve that opens the flow path;
A blood bag system comprising:
The blood bag system according to claim 1, wherein the pressure on-off valve is provided on a flow path passing through the third tube or on a flow path within the branch section toward the third tube.
3. The blood bag system according to claim 1 or 2, wherein said opening pressure of said pressure on-off valve is higher than the pressure of said additive solution acting due to the head difference between said third bag and said pressure on-off valve. system.
The blood bag system according to any one of claims 1 to 3, wherein the opening pressure of the pressure on-off valve is 3.3 kPa or more.
The blood bag system according to any one of claims 1 to 4, wherein the opening pressure of the pressure on-off valve is 200 kPa or less.
The blood bag system according to any one of claims 1 to 5, wherein said pressure on-off valve is provided inside said branch.
The blood bag system according to any one of claims 1 to 6, wherein the pressure on-off valve is
a plate-like valve body that closes the flow path;
a support portion that abuts against the wall surface of the channel;
a slit passing through the central axis of the valve body and penetrating the valve body in the thickness direction;
A blood bag system comprising:
The blood bag system according to claim 7, wherein a plurality of said slits are radially provided.
The blood bag system according to claim 7 or 8, wherein the axial thickness of the flow path of the valve body is thinner than the axial thickness of the support portion.
The blood bag system according to any one of claims 7 to 9, wherein said pressure on-off valve is made of rubber or elastomer.
A blood processing method using the blood bag system according to claim 1,
separating the blood in the first bag into blood components under the action of centrifugal force;
pressurizing the first bag to open the pressure on-off valve and transfer a portion of the blood components to the second bag;
transferring the additive solution in the third bag to the first bag by gravity flow;
A method of treating blood, comprising:
The method for treating blood according to claim 11,
After separating the blood in the first bag into blood components under the action of the centrifugal force,
clamping the third tube;
removing the clamp from the third tube after depressurizing the first bag;
A method of treating blood, further comprising: