WO2022184657A1 - Composition antimicrobienne - Google Patents
Composition antimicrobienne Download PDFInfo
- Publication number
- WO2022184657A1 WO2022184657A1 PCT/EP2022/055018 EP2022055018W WO2022184657A1 WO 2022184657 A1 WO2022184657 A1 WO 2022184657A1 EP 2022055018 W EP2022055018 W EP 2022055018W WO 2022184657 A1 WO2022184657 A1 WO 2022184657A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- silver
- composition
- microbial
- personal care
- Prior art date
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- CQQFHQIXAHHOHI-UHFFFAOYSA-M sodium 3-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC(=O)NCCN(CCO)CC(CS(=O)(=O)[O-])O.[Na+] CQQFHQIXAHHOHI-UHFFFAOYSA-M 0.000 description 1
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- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
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- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
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- FMYOMWCQJXWGEN-WYRLRVFGSA-M sodium;(2r,3r,4s,5r,6r)-2,3,4,5,6,7-hexahydroxyheptanoate Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C([O-])=O FMYOMWCQJXWGEN-WYRLRVFGSA-M 0.000 description 1
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical group [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 description 1
- UOZFSLAMWIZUEN-UHFFFAOYSA-M sodium;2-[2-(decanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O UOZFSLAMWIZUEN-UHFFFAOYSA-M 0.000 description 1
- BVAQZSBSTBYZPX-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)-[2-hydroxy-3-[hydroxy(oxido)phosphoryl]oxypropyl]azaniumyl]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC[N+](CCO)(CC([O-])=O)CC(O)COP(O)([O-])=O BVAQZSBSTBYZPX-UHFFFAOYSA-M 0.000 description 1
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 1
- ZKBGPOVFSMIXBF-UHFFFAOYSA-M sodium;2-[2-hydroxyethyl-[2-(octadecanoylamino)ethyl]amino]acetate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O ZKBGPOVFSMIXBF-UHFFFAOYSA-M 0.000 description 1
- YASOXPMFSCKYDU-UHFFFAOYSA-M sodium;2-[2-hydroxyethyl-[2-(octanoylamino)ethyl]amino]acetate Chemical compound [Na+].CCCCCCCC(=O)NCCN(CCO)CC([O-])=O YASOXPMFSCKYDU-UHFFFAOYSA-M 0.000 description 1
- IDXHDUOOTUFFOX-UHFFFAOYSA-M sodium;2-[2-hydroxyethyl-[2-(tetradecanoylamino)ethyl]amino]acetate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O IDXHDUOOTUFFOX-UHFFFAOYSA-M 0.000 description 1
- IPYKAMBNXWKFTC-KVVVOXFISA-M sodium;2-[2-hydroxyethyl-[2-[[(z)-octadec-9-enoyl]amino]ethyl]amino]acetate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)NCCN(CCO)CC([O-])=O IPYKAMBNXWKFTC-KVVVOXFISA-M 0.000 description 1
- HPHSQXYITTYVEY-KVVVOXFISA-M sodium;2-hydroxy-3-[2-hydroxyethyl-[2-[[(z)-octadec-9-enoyl]amino]ethyl]amino]propane-1-sulfonate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)NCCN(CCO)CC(O)CS([O-])(=O)=O HPHSQXYITTYVEY-KVVVOXFISA-M 0.000 description 1
- HWCHICTXVOMIIF-UHFFFAOYSA-M sodium;3-(dodecylamino)propanoate Chemical compound [Na+].CCCCCCCCCCCCNCCC([O-])=O HWCHICTXVOMIIF-UHFFFAOYSA-M 0.000 description 1
- LLKGTXLYJMUQJX-UHFFFAOYSA-M sodium;3-[2-carboxyethyl(dodecyl)amino]propanoate Chemical compound [Na+].CCCCCCCCCCCCN(CCC(O)=O)CCC([O-])=O LLKGTXLYJMUQJX-UHFFFAOYSA-M 0.000 description 1
- WMLIJOUAGPIENT-UHFFFAOYSA-M sodium;3-[2-hydroxyethyl-[2-(octanoylamino)ethyl]amino]propanoate Chemical compound [Na+].CCCCCCCC(=O)NCCN(CCO)CCC([O-])=O WMLIJOUAGPIENT-UHFFFAOYSA-M 0.000 description 1
- LOBXNKKFDKXXQW-UHFFFAOYSA-M sodium;3-[dodecanoyl(methyl)amino]propanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCC([O-])=O LOBXNKKFDKXXQW-UHFFFAOYSA-M 0.000 description 1
- QEKATQBVVAZOAY-UHFFFAOYSA-M sodium;4-propan-2-ylbenzenesulfonate Chemical compound [Na+].CC(C)C1=CC=C(S([O-])(=O)=O)C=C1 QEKATQBVVAZOAY-UHFFFAOYSA-M 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 125000004354 sulfur functional group Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- KWXLCDNSEHTOCB-UHFFFAOYSA-J tetrasodium;1,1-diphosphonatoethanol Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P(=O)([O-])C(O)(C)P([O-])([O-])=O KWXLCDNSEHTOCB-UHFFFAOYSA-J 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 235000019303 thiodipropionic acid Nutrition 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229910001773 titanium mineral Inorganic materials 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 1
- FKLSONDBCYHMOQ-ONEGZZNKSA-N trans-dodec-9-enoic acid Chemical compound CC\C=C\CCCCCCCC(O)=O FKLSONDBCYHMOQ-ONEGZZNKSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 125000005209 triethanolammonium group Chemical class 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- FYZXEMANQYHCFX-UHFFFAOYSA-K tripotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [K+].[K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O FYZXEMANQYHCFX-UHFFFAOYSA-K 0.000 description 1
- 229940117565 trisodium dicarboxymethyl alaninate Drugs 0.000 description 1
- 229940048198 trisodium hedta Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- WHNXAQZPEBNFBC-UHFFFAOYSA-K trisodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].OCCN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O WHNXAQZPEBNFBC-UHFFFAOYSA-K 0.000 description 1
- OHOTVSOGTVKXEL-UHFFFAOYSA-K trisodium;2-[bis(carboxylatomethyl)amino]propanoate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(C)N(CC([O-])=O)CC([O-])=O OHOTVSOGTVKXEL-UHFFFAOYSA-K 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 239000007195 tryptone soya broth Substances 0.000 description 1
- SOECUQMRSRVZQQ-UHFFFAOYSA-N ubiquinone-1 Chemical compound COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O SOECUQMRSRVZQQ-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- the present invention relates to an anti-microbial composition comprising a silver compound. More specifically, the present invention relates to an anti-microbial composition comprising a silver compound that can be used in personal care or home care compositions.
- Silver has long been known to be anti-microbial. For instance, newborns were routinely swabbed with silver nitrate to prevent blinding eye infections until the past decade when nitrates were indicated to cause other problems. Silver is a broad-range anti-microbial agent that has proven effective against most harmful microorganisms present in everyday life such as E. coli, P. aeruginosa, S. aureus, P. acnes, A. niger, C. albicans, M. furfur. Silver sulfadiazine is commonly used as an antibiotic burn dressing in the form of a topical cream containing 1% silver sulfadiazine in micronized form.
- US5688981 discloses novel silver chelating agents and surfactants that exhibit photosensitivity and anti-microbial activity.
- the silver is chelated with ethylenediaminetriacetic acid (ED3A) or with N-acyl ED3A.
- ED3A ethylenediaminetriacetic acid
- N-acyl ED3A N-acyl ED3A.
- Anti-microbial activity is exhibited even at very low silver levels.
- EP2986698 discloses soap bars, in particular, high pH soap bars that provide improved biocidal activity against Gram-positive and Gram-negative bacteria in the relatively short contact times typical of bar use.
- EP3099773 discloses cleansing compositions comprising a surfactant, an oligodynamic metal, a chelating agent, and a polymer having a group comprising a site having one or more lone pair of electrons.
- the compositions disclosed provide improved biocidal activity against Gram-positive and Gram-negative bacteria in a relatively short contact time.
- EP3099772 discloses an aqueous composition comprising an oligodynamic metal or ions thereof, a chelating agent, and free alkali less than 1 wt%.
- JP5377003 discloses silver oxide mixed with phytic acid and a chelating agent such as ethylenediaminetetraacetic acid to improve the stability of the formulation and avoid discolouration due to UV radiation.
- Phytic acid also called inositol polyphosphate, produces phytate anion at physiological pH. Both phytic acid and phytate ion have strong binding affinity to dietary minerals like zinc, calcium and iron inhibiting their absorption and leading to precipitate formation.
- the present invention provides an anti-microbial composition comprising at least one silver compound, at least one amino acid, at least one fatty acid, and water.
- the present invention provides the use of an anti-microbial composition as described herein in a personal care or home care composition, preferably as an anti-microbial agent.
- the present invention provides a personal care or home care composition comprising an anti-microbial composition as described herein.
- the present invention provides a process for preparing an anti microbial composition as described herein, wherein the composition is prepared by mixing at least one silver compound, at least one amino acid, at least one fatty acid, and water.
- Silver, zinc, copper and other metals are widely used in anti-microbial cleansing / cleaning compositions.
- their oxides and some salts, especially that of silver are sensitive to pH, heat and light. Under such conditions, the active metal tends to discolour to form brown, gray or black particles. The particles are prone to settling and/or agglomeration.
- most silver oxides and salts are poorly soluble in water.
- Silver-based anti-microbial agents have very good anti-microbial effect. However, their efficacy often tends to gradually diminish over time, especially in the alkaline environment of a cleansing / cleaning composition.
- the present invention thus provides a stable, non-toxic anti-microbial composition and a process for preparing the anti-microbial composition which is cost-effective and can be scaled up for commercial production.
- the following definitions apply unless specifically stated otherwise. Unless otherwise stated, all percentages are by weight (w/w) of the respective component or the total composition, respectively.
- wt.-% means percentage by weight; “vol.-%” means percentage by volume; “mol-%” means percentage by mole. Unless otherwise stated, all ratios are weight ratios (weight per weight). Preferably, references to ‘parts’ e.g. a mixture of 1 part X and 3 parts Y, is a ratio by weight. +/- indicates the standard deviation. All ranges are inclusive and combinable. Unless otherwise stated, all measurements are understood to be made at 23 °C and at ambient conditions, where “ambient conditions” means at approximately 1 atmosphere (atm) of pressure and at about 50 % relative humidity. “Relative humidity” refers to the ratio (stated as a percent) of the moisture content of air compared to the saturated moisture level at the same temperature and pressure.
- Relative humidity can be measured with a hygrometer, in particular with a probe hygrometer from VWR ® International.
- min means “minute” or “minutes”.
- mol means mole.
- g following a number means “gram” or “grams”.
- Ex.” means “example”.
- q.s.” and “Q.S.” means quantum sates, thus, as much as needed. In the context of contents, this refers to the mass to obtain 100 wt.-% as total. For instance, the water is filled up to obtain a sum of 100 wt.- % of all ingredients.
- pH pH
- compositions of the subject invention are described as “including” or “comprising” specific components or materials, narrower embodiments where the compositions can “consist essentially of” or “consist of” the recited components or materials are also contemplated.
- “Derivatives” includes but is not limited to, amide, ether, ester, amino, carboxyl, acetyl, acid, salt and/or alcohol derivatives of a given compound. In at least one embodiment, “derivatives thereof” means the amide, ether, ester, amino, carboxyl, acetyl, acid, salt and alcohol derivatives.
- an "anti-microbial” is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or viruses. Anti-microbial substances either kill microbes (microbiocidal) or prevent the growth of microbes (microbiostatic).
- ppm or “parts per million” is the measurement of the concentration of a solution. 1 ppm is one part by weight, or volume, of solute in 1 million parts by weight, or volume, of solution.
- Cosmetically acceptable may be understood in the broadest sense in that the compositions or components described are suitable for use in contact with human keratinous tissue without undue toxicity, incompatibility, instability, allergic response, and the like. All compositions described herein which have the purpose of being directly applied to keratinous tissue are cosmetically acceptable.
- the present invention provides an anti-microbial composition
- an anti-microbial composition comprising at least one silver compound, at least one amino acid, at least one fatty acid, and water.
- the anti-microbial composition of the present invention comprises at least one silver compound.
- Suitable silver compounds that may be used include, but are not limited to, silver oxide, silver halides such as silver chloride, silver iodide, silver bromide, silver fluoride, silver citrate, silver acetate, silver nitrate, silver carbonate, silver sulphate, silver sulphide, silver phosphate, silver benzoate, silver salicylate, and mixtures thereof.
- the silver compound used may be silver oxide.
- the silver compound may be present from 0.01 to 0.3 wt.-%, preferably from 0.09 to 0.11 wt.-%, more preferably from 0.095 to 0.105 wt.-%, and most preferably from 0.099 to 0.101 wt.-%, based on the total weight of the anti-microbial composition.
- the anti-microbial composition of the present invention comprises at least one amino acid. Any of a variety of amino acids and their derivatives may be used. Suitable amino acids can be alpha-, beta-, gamma- or delta- amino acids having aliphatic, acyclic, or aromatic side chains, and/or containing hydroxyl or sulphur groups.
- suitable amino acids are, but not limited to, alanine, arginine, asparagine, aspartic acid, lysine, leucine, isoleucine, glycine, glutamic acid, serine, threonine, glutamine, histidine, methionine, proline, tyrosine, cysteine, phenylalanine, tryptophan, valine, and mixtures thereof.
- suitable amino acids are, but not limited to, alanine, arginine, asparagine, aspartic acid, lysine, leucine, isoleucine, glycine, glutamic acid, serine, threonine, glutamine, histidine, methionine, proline, tyrosine, cysteine, phenylalanine, tryptophan, valine, and mixtures thereof.
- non-proteinogenic amino acids such as hydroxyproline, citrulline, ornithine, selenomethionine,
- the amino acid is present from 0.2 to 6 wt.-%, more preferably from 1 .0 to 3.0 wt.-%, and most preferably from 1.5 to 2.5 wt.-%, based on the total weight of the anti-microbial composition.
- the anti-microbial composition of the present invention comprises at least one fatty acid.
- Suitable fatty acids include saturated as well as unsaturated fatty acids, linear or branched, having a carbon chain length of Ce to C22.
- the fatty acid is an aliphatic acid with carbon chain length from Ce to C22.
- the fatty acids may be saturated or unsaturated fatty acids.
- unsaturated fatty acids may be mono-unsaturated, di-unsaturated, tri-unsaturated, tetra-unsaturated, penta- unsaturated or hexa-unsaturated.
- Suitable fatty acids include, but are not limited to, caproic acid, enanthic acid, caprylic acid, pelargonic acid, capric acid, undecylic acid, lauric acid, tridecylic acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, behenic acid, stearic acid, nonadecylic acid, arachidic acid, heneicosylic acid, myristoleic acid, palmitoleic acid, sapienic acid, elaidic acid, vaccenic acid, oleic acid, gadoleic acid, eicosenoic acid, paullinic acid, erucic acid, linoleic acid, eicosadienoic acid, linolelaidic acid, docosadienoic acid, a- and y-linolenic acid, pinolenic acid, a- and b-eleostearic acid, mead acid
- the fatty acid is present from 0.025 to 0.75 wt.-%, more preferably from 0.1 to 0.5 wt.-%, and most preferably from 0.2 to 0.3 wt.-%, based on the total weight of the anti-microbial composition.
- the silver compound (particularly preferably silver oxide) is present from 0.01 to 0.3 wt.- %, based on the total weight of the anti-microbial composition; the amino acid (particularly preferably arginine) is present from 0.2 to 6 wt.-%, based on the total weight of the anti-microbial composition; and the fatty acid (particularly preferably caprylic acid) is present from 0.025 to 0.75 wt.-%, based on the total weight of the anti-microbial composition.
- the silver compound (particularly preferably silver oxide) is present from 0.09 to 0.11 wt.-%, based on the total weight of the anti-microbial composition; the amino acid (particularly preferably arginine) is present from 1.0 to 3.0 wt.-%, based on the total weight of the anti-microbial composition; and the fatty acid (particularly preferably caprylic acid) is present from 0.1 to 0.5 wt.-%, based on the total weight of the anti-microbial composition.
- the silver compound (particularly preferably silver oxide) is present from 0.095 to 0.105 wt.-%, based on the total weight of the anti-microbial composition; the amino acid (particularly preferably arginine) is present from 1.5 to 2.5 wt.-%, based on the total weight of the anti-microbial composition; and the fatty acid (particularly preferably caprylic acid) is present from 0.2 to 0.3 wt.-%, based on the total weight of the anti-microbial composition.
- the anti-microbial composition of the present invention comprises from 0.01 to 0.3 wt.-% of silver oxide, based on the total weight of the anti-microbial composition; from 0.2 to 6 wt.-% of arginine, based on the total weight of the anti-microbial composition; and from 0.025 to 0.75 wt.-% of caprylic acid, based on the total weight of the anti-microbial composition.
- the anti-microbial composition of the present invention comprises water.
- Water is useful for economic and ecological reasons.
- water may be demineralized water, deionized water, distilled water, mineral water, or tap water, preferably demineralized water.
- the anti-microbial composition of the present invention comprises from 10 to 99.9 wt.-%, or from 10 to 98.5 wt.-%, or from 10 to 98 wt.-%, or from 10 to 97.8 wt.-%, or from 10 to 97.5 wt.-%, or from 10 to 97 wt.-%, or from 10 to 95 wt.-%, or from 20 to 94 wt.-%, or from 30 to 93 wt.-%, or from 40 to 92 wt.- %, or from 50 to 91 wt.-%, or from 60 to 90 wt.-%, or from 70 to 90 wt.-% of water, based on the total weight of the composition.
- the anti-microbial composition of the present invention may comprise an additional solvent.
- the solvent is cosmetically acceptable.
- the composition comprises water-miscible or water-soluble solvents such as lower alkyl alcohols.
- the composition comprises C1-C5 alkyl monohydric alcohols, preferably C2-C3 alkyl monohydric alcohols.
- the alcohols which may be present are in particular lower monohydric or polyhydric alcohols having 1 to 4 carbon atoms, such as preferably ethanol or isopropanol.
- the composition comprises a water-soluble polyhydric alcohol.
- the water-soluble polyhydric alcohols are polyhydric alcohols having two or more hydroxyl groups in the molecule.
- the water-soluble polyhydric alcohol is selected from the group consisting of: dihydric alcohols such as ethylene glycol, propylene glycol, trimethylene glycol, 1 ,2-butylene glycol, 1 ,3-butylene glycol, 1 ,4-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1 ,4- diol, hexylene glycol, octylene glycol; trihydric alcohols such as glycerine, trimethylol propane, 1 ,2,6-hexanetriol and the like; tetrahydric alcohols such as penthaerythritol; pentahydric alcohols such as xylytol, etc.
- Natural solvents can also be used.
- the composition comprises a solvent selected from the group consisting of plant oil, honey, plant- derived sugar compositions, and mixtures thereof.
- the anti-microbial composition is stable to light and heat at accelerated stability conditions for one month, preferably three months, more preferably six months. In a preferred embodiment, the anti-microbial composition is stable to light and heat at accelerated stability conditions for at least one month, preferably at least three months, more preferably at least six months. Unless otherwise stated, the term accelerated stability conditions refers to 40 ⁇ 2 °C temperature and 75 ⁇ 5% humidity.
- the anti-microbial composition of the present invention can be prepared by methods known in the art. In preferred embodiments, the anti-microbial composition is prepared by the process of the present invention.
- the present invention provides a process for preparing an anti-microbial composition as described herein, wherein the composition is prepared by mixing at least one silver compound, at least one amino acid, at least one fatty acid, and water.
- the anti-microbial composition of the present invention is prepared by a process comprising the following steps: a. mixing water and at least one amino acid at room temperature and heating the reaction blend; b. adding at least one silver compound to the above reaction blend and maintaining for at least 2 hours; c. adding water to the reaction blend; d. adding at least one fatty acid and maintaining the reaction blend for 1-2 hours under stirring; e. filtering the reaction blend to obtain the anti-microbial composition; f. optionally, adding water to the anti-microbial composition to adjust the silver concentration at desired levels.
- reaction blend is to be understood as a mixture of starting materials and optionally any solvents or other materials employed in or useful for the reaction.
- the heating in step (a) occurs by heating the reaction blend to at least 35°C, more preferably at least 40°C, even more preferably at least 45°C, most preferably from 40°C to 50°C.
- the maintaining in step (b) occurs for at least 3 hours, more preferably at least 4-6 hours, most preferably at least 4 hours.
- the step (c) occurs at at least 25°C, more preferably at least 30°C, even more preferably at least 35°C, most preferably from 30°C to 35°C.
- the filtration in step (e) occurs using hyflowbed at room temperature.
- the anti-microbial composition of the invention is incorporated into a personal care composition or a home care composition.
- the anti-microbial composition of the invention is incorporated into a personal care composition.
- the anti-microbial composition of the invention is incorporated into a home care composition.
- the anti-microbial composition of the invention is incorporated into a personal care composition or a home care composition to provide an anti-microbial effect.
- the anti-microbial composition of the invention is used as an anti-microbial agent.
- the present invention provides the use of an anti-microbial composition as described herein in a personal care or home care composition, preferably as an anti-microbial agent.
- the present invention provides the use of an anti-microbial composition as described herein as an anti-microbial agent in a personal care or home care composition.
- the present invention provides the use of an anti-microbial composition as described herein in a personal care composition.
- the present invention provides the use of an anti microbial composition as described herein in a home care composition.
- the present invention provides the use of an anti-microbial composition as described herein as an anti-microbial agent in a personal care composition.
- the present invention provides the use of an anti-microbial composition as described herein as an anti-microbial agent in a home care composition.
- the present invention provides a personal care or home care composition comprising an anti-microbial composition as described herein.
- the present invention provides a personal care composition comprising an anti-microbial composition as described herein.
- the present invention provides a home care composition comprising an anti-microbial composition as described herein.
- the personal care composition is selected from the group consisting of shampoo, hair and/or skin conditioner, body wash, hand wash, facial cleanser, face mask, bubble bath, intimate wash, bath oil, cleansing milk, micellar water, make-up remover, cleansing wipes, hair mask, perfume, liquid soap, shaving soap, shaving foam, cleansing foam, day cream, anti-ageing cream, body milk, body lotion, body mousse, face serum, eye cream, sunscreen lotion, sun cream, face cream, after-shave lotion, pre-shaving cream, depilatory cream, skin-whitening gel, self-tanning cream, anti-acne gel, mascara, foundation, primer, concealer, blush, bronzer, blemish balm (bb) cream, eyeliner, night cream, eye brow gel, highlighter, lip stain, hand sanitizer, hair oil, nail varnish remover, hair styling gel, hair styling cream, anti-frizz serum, scalp treatment, hair colorant, split end fluid, deodorant, antiperspirant, baby cream, insect repellent
- the personal care composition is a hand wash, body wash, deodorant or antiperspirant. In at least one preferred embodiment, the personal care composition is for use on skin. In at least one preferred embodiment, the personal care composition is for use on body. In at least one preferred embodiment, the personal care composition is for use on hand. In a particular embodiment, the personal care composition is a body wash.
- the personal care composition is a hand wash.
- the personal care composition is a deodorant or an antiperspirant.
- the composition is an emulsion or gel, preferably an oil-in-water (o/w) emulsion, cream gel or hydrogel.
- the home care composition is selected from the group consisting of laundry detergent, fabric softener, multipurpose cleaner, household cleaner, hard surface cleaner such as floor cleaner, toilet cleaner, bathroom cleaner, kitchen cleaner.
- the home care composition may be a hand dishwashing composition.
- the home care composition is a laundry detergent, fabric softener or multipurpose cleaner.
- the home care composition is for use on fabric.
- the personal care composition is for use on hard surfaces.
- the home care composition is a laundry detergent.
- the laundry detergent may, for example, be in the form of a liquid or in the form of a powder.
- the home care composition is a fabric softener.
- the home care composition is a multipurpose cleaner.
- the home care composition is a hard surface cleaner.
- the multipurpose cleaner or hard surface cleaner may, for example, be used to clean ceramic surfaces, stone surfaces, porcelain surfaces, glass surfaces, stainless steel surfaces, metal surfaces, plastic surfaces, linoleum surfaces or wood surfaces.
- the multipurpose cleaner or hard surface cleaner may be used to:
- the multipurpose cleaner or hard surface cleaner remains on the surface after application ("leave-on” application). In another embodiment, the multipurpose cleaner or hard surface cleaner is removed from the surface after application and preferably rinsed off with water (“rinse-off” application).
- the personal care or home care composition comprises from 0.0001 to 10 wt.- %, preferably from 0.0005 to 10 wt.-%, more preferably from 0.001 to 10 wt.-%, particularly preferably from 0.01 to 5 wt.-% of the anti-microbial composition, based on the total weight of the personal care or home care composition.
- the amount of the at least one silver compound in the personal care or home care composition of the invention is from greater than 0 to 10%, preferably from 0.0001% to 10% by weight, more preferably from 0.0005% to 5% by weight, and especially preferably from 0.0005% to 1 % by weight, based on the total weight of the personal care or home care composition of the invention.
- the at least one silver compound is present from 1 ppm to 10000 ppm, more preferably from 5 ppm to 1000 ppm, and most preferably from 5 ppm to 100 ppm in the personal care or home care composition of the present invention.
- the personal care or home care composition of the invention may comprise one or more further components, which can be in an amount of at least 0.01% by weight, preferably at least 0.05% by weight, more preferably at least 0.1% by weight, even more preferably at least 0.5% by weight, particularly preferably at least 1 % by weight of the personal care or home care composition.
- the further component is selected from the group consisting of acidity regulators, colorants, conditioning agents, emulsifiers, film formers, fragrances, glossers, humectants, lubricants, moisturizers, pigments, preservatives, skin penetration enhancers, stabilizers, surfactants, thickeners, and viscosity modifiers. More preferably, the further component is selected from the group consisting of acidity regulators, glossers, lubricants, and surfactants. Suitable lubricants are, for example, fatty alcohol components having 6 to 18 carbon atoms. The surfactants may, for example, be selected from non-polymeric, cationic quaternary ammonium compounds, in particular cetrimonium chloride (CTAC).
- CCTAC cetrimonium chloride
- the personal care or home care composition of the invention may optionally comprise anionic surfactants, for example alkylbenzenesulfonates, alkyl sulfates, alkyl ether sulfates, alkanesulfonates, alkyl ether carboxylic acids, sulfosuccinates, isethionates, taurates, glycinates and/or acylglutamates.
- anionic surfactants for example alkylbenzenesulfonates, alkyl sulfates, alkyl ether sulfates, alkanesulfonates, alkyl ether carboxylic acids, sulfosuccinates, isethionates, taurates, glycinates and/or acylglutamates.
- the alkyl chains of the surfactants mentioned may be of synthetic or natural origin and consist of 8 to 30, preferably 8 to 18 and more preferably 12 to 14 carbon atoms in a linear or branche
- the anionic surfactants are selected from alkylbenzenesulfonates and alkyl ether sulfates.
- Preferred alkylbenzenesulfonates are linear alkylbenzenesulfonates having an alkyl chain length of Ce-Cis, preferably C12-C14.
- Anionic surfactants that are used in accordance with the invention are preferably aliphatic sulfates such as fatty alcohol sulfates, fatty alcohol ether sulfates, dialkyl ether sulfates, monoglyceride sulfates, and aliphatic sulfonates such as alkanesulfonates, olefinsulfonates, ether sulfonates, n-alkyl ether sulfonates, ester sulfonates and lignosulfonates.
- aliphatic sulfates such as fatty alcohol sulfates, fatty alcohol ether sulfates, dialkyl ether sulfates, monoglyceride sulfates, and aliphatic sulfonates such as alkanesulfonates, olefinsulfonates, ether sulfonates, n-alkyl ether sulfonates, este
- alkylbenzenesulfonates fatty acid cyanamides, sulfosuccinates (sulfosuccinic esters), sulfosuccinamates, sulfosuccinamides, fatty acid isethionates, acylaminoalkanesulfonates (fatty acid taurides), fatty acid sarcosinates, ether carboxylic acids and alkyl (ether) phosphates, and also [alpha]-sulfo fatty acid salts, acylglutamates, monoglyceride disulfates and alkyl ethers of glycerol disulfate.
- fatty alcohol sulfates and/or fatty alcohol ether sulfates preference is given to the fatty alcohol sulfates.
- Fatty alcohol sulfates are products of sulfation reactions on corresponding alcohols
- fatty alcohol ether sulfates are products of sulfation reactions on alkoxylated alcohols.
- alkoxylated alcohols generally understands alkoxylated alcohols to mean the reaction products of alkylene oxide, preferably ethylene oxide, with alcohols, in the context of the present invention preferably with longer-chain alcohols.
- n moles of ethylene oxide and one mole of alcohol give rise to a complex mixture of addition products of different degrees of ethoxylation.
- a further embodiment of the alkoxylation involves the use of mixtures of alkylene oxides, preferably of the mixture of ethylene oxide and propylene oxide.
- Preferred fatty alcohol ether sulfates are the sulfates of fatty alcohols having low levels of ethoxylation with 1 to 4 ethylene oxide units (EO), especially 1 to 2 EO, for example 1.3 EO.
- the anionic surfactants are typically used in the form of salts, but also in acid form.
- the salts are preferably alkali metal salts, alkaline earth metal salts, ammonium salts and mono-, di- or trialkanolammonium salts, for example mono-, di- or triethanolammonium salts, especially lithium, sodium, potassium or ammonium salts, more preferably sodium or potassium salts, especially preferably sodium salts.
- the anionic surfactant is an acylglycinate surfactant.
- the acylglycinate surfactant conforms to Formula (Y): wherein
- R 1a is a linear or branched, saturated alkyl group having 6 to 30, preferably 8 to 22, particularly preferably 8 to 18 carbon atoms or is a linear or branched, mono- or polyunsaturated alkenyl group having 6 to 30, preferably 8 to 22 and particularly preferably 12 to 18 carbon atoms, and Q a + is a cation.
- Q a + is selected from the group consisting of Li + , Na + , K + , Mg ++ , Ca ++ , Al +++ , NH 4 + , a monoalkylammmonium ion, a dialkylammonium ion, a trialkylammonium ion and a tetraalkylammonium ion, or combinations thereof.
- R 1a is (Ci-C 22 )-alkyl or (C 2 -Cio)-hydroxyalkyl.
- the acylglycinate surfactant is selected from sodium cocoylglycinate and potassium cocoylglycinate.
- the acylglycinate surfactant is selected from those conforming to Formula (Y), wherein R 1a is Cn-alkyl, Ci 2 -alkyl, Ci 3 -alkyl or Ci 4 -alkyl, particularly preferably Cn-alkyl or Ci 3 -alkyl.
- the acylglycinate surfactant is selected from those conforming to Formula (Y), wherein R 1a is Cis-alkyl, Ci 6 -alkyl, Ci 7 -alkyl or Cis-alkyl, particularly preferably Cis-alkyl or Ci 7 -alkyl.
- the anionic surfactant is a glutamate surfactant.
- the anionic surfactant is a glutamate surfactant corresponding to Formula (Z) or a salt thereof: wherein R’ is HOOC-CH 2 -CH 2 - or M + OOC-CH 2 -CH 2 - wherein M + is a cation; and wherein R is a linear or branched, saturated alkyl group having 6 to 30, preferably 8 to 22, more preferably 8 to 18 carbon atoms or is a linear or branched, mono- or polyunsaturated alkenyl group having 6 to 30, preferably 8 to 22, more preferably 12 to 18 carbon atoms.
- M + is a metal cation.
- M + is selected from the group consisting of Li + , Na + , K + , Mg ++ , Ca ++ , Al +++ , NH 4 + , a monoalkylammmonium ion, a dialkylammonium ion, a trialkylammonium ion and a tetraalkylammonium ion, or combinations thereof.
- the glutamate surfactant is selected from sodium cocoyl glutamate and potassium cocoyl glutamate.
- the glutamate surfactant is selected from those conforming to Formula (Z), wherein R is Cn-alkyl, C 12 - alkyl, Ci 3 -alkyl or Ci 4 -alkyl, particularly preferably Cn-alkyl or Ci 3 -alkyl.
- the glutamate surfactant is selected from those conforming to Formula (Z), wherein R is Cis-alkyl, Ci 6 -alkyl, Ci 7 -alkyl or Cis-alkyl, particularly preferably Cis-alkyl or Ci7-alkyl.
- the composition comprises from 0.01 wt% to 30 wt%, preferably from 1 wt% to 25 wt%, more preferably from 5 wt% to 20 wt%, even more preferably from 12 wt% to 18 wt% glutamate surfactant.
- the personal care or home care composition may, for example, comprise from 0.5 wt.- % to 45 wt.-%, preferably from 1 wt.-% to 30 wt.-%, more preferably from 2 wt.-% to 25 wt.-%, more preferably from 5 wt.-% to 20 wt.-%, more preferably from 12 wt.-% to 18 wt.-% anionic surfactant.
- surfactants may be nonionic, amphoteric and/or cationic surfactants, for example betaines, amidobetaines, amine oxides, amidoamine oxides, fatty alcohol polyglycol ethers, alkyl polyglycosides or quaternary ammonium compounds.
- nonionic surfactants may, for example, be alkoxylates, such as polyglycol ethers, fatty alcohol polyglycol ethers (fatty alcohol alkoxylates), alkyl phenol polyglycol ethers, end group-capped polyglycol ethers, mixed ethers and hydroxy mixed ethers, and fatty acid polyglycol esters.
- alkoxylates such as polyglycol ethers, fatty alcohol polyglycol ethers (fatty alcohol alkoxylates), alkyl phenol polyglycol ethers, end group-capped polyglycol ethers, mixed ethers and hydroxy mixed ethers, and fatty acid polyglycol esters.
- usable are ethylene oxide-propylene oxide block copolymers and fatty acid alkanolamides and fatty acid polyglycol ethers.
- a further important class of nonionic surfactants that can be used in accordance with the invention is that of the polyol surfactants and here
- Suitable fatty alcohol polyglycol ethers are ethylene oxide (EO)- and/or propylene oxide (PO)-alkoxylated, unbranched or branched, saturated or unsaturated C 8 -C 22 alcohols having an alkoxylation level of up to 30, preferably ethoxylated C 10 -C 18 fatty alcohols having an ethoxylation level of less than 30, more preferably 1 to 20, especially preferably 1 to 12 and exceptionally preferably 1 to 8, for example C 12 -C 14 fatty alcohol ethoxylates with 8 EO.
- EO ethylene oxide
- PO propylene oxide
- Alkyl polyglycosides are surfactants that can be obtained by the reaction of sugars and alcohols by the relevant methods of preparative organic chemistry, which results in a mixture of monoalkylated, oligomeric or polymeric sugars according to the manner of preparation.
- Preferred alkyl polyglycosides are the alkyl polyglucosides, where the alcohol is more preferably a long-chain fatty alcohol or a mixture of long-chain fatty alcohols having branched or unbranched Cs- to Cis-alkyl chains and the oligomerization level (DP) of the sugars is from 1 to 10, preferably from 1 to 6, more preferably from 1.1 to 3 and especially preferably from 1.1 to 1.7, for example C 8 -Cio-alkyl-1 ,5-glucoside (DP of 1.5).
- the alcohol is more preferably a long-chain fatty alcohol or a mixture of long-chain fatty alcohols having branched or unbranched Cs- to Cis-alkyl chains and the oligomerization level (DP) of the sugars is from 1 to 10, preferably from 1 to 6, more preferably from 1.1 to 3 and especially preferably from 1.1 to 1.7, for example C 8 -Cio-alkyl-1 ,5-glucoside (DP
- the nonionic surfactant is selected from N-methyl-N- acylglucamines, preferably N-methyl-N-acylglucamines of Formula (X): wherein R a is selected from saturated or unsaturated hydrocarbon chains having 5 to 23 carbon atoms.
- R a in Formula (X) is selected from saturated or unsaturated hydrocarbon chains having 7 to 17 carbon atoms.
- R a in Formula (X) is selected from saturated hydrocarbon chains having 7 to 17 carbon atoms.
- R a in Formula (X) is selected from unsaturated hydrocarbon chains having 7 to 17 carbon atoms.
- the personal care or home care composition may, for example, comprise from 0.5 wt.- % to 20 wt.-%, preferably from 1 wt.-% to 10 wt.-%, more preferably from 2 wt.-% to 5 wt.-% nonionic surfactant.
- amphosurfactants that are usable in accordance with the invention include betaines, amine oxides, alkylamidoalkylamines, alkyl-substituted amino acids, acylated amino acids and biosurfactants.
- Suitable betaines are the alkyl betaines, the alkylamidobetaines, the imidazolinium betaines, the sulfobetaines (INCI Sultaines) and the amidosulfobetaines, and also the phosphobetaines.
- betaines and sulfobetaines are the following compounds named according to INCI: Almondamidopropyl Betaine, Apricotamidopropylbetaine, Avocadamidopropylbetaine, Babassuamidopropylbetaine, Behenamidopropylbetaine, Behenylbetaine, Betaine, Canolamidopropylbetaine, Capryl/Capramidopropylbetaine, Carnitine, Cetylbetaine, Cocamidoethylbetaine, Cocamidopropylbetaine, Cocamidopropylhydroxysultaine, Cocobetaine, Cocohydroxysultaine, Coco/Oleamidopropylbetaine, Coco-Sultaine, Decylbetaine, Dihydroxyethyloleylglycinate, Dihydroxyethyl Soy Glycinate, Dihydroxyethylstearylglycinate, Dihydroxyethyl Tallow Glycinate, Dimethicone Propy
- Minkamidopropylbetaine Myristamidopropylbetaine, Myristylbetaine, Oleamidopropylbetaine, Oleamidopropylhydroxysultaine, Oleylbetaine, Olivamidopropylbetaine, Palmamidopropylbetaine, Palmitamidopropylbetaine, Palmitoyl Carnitine, Palm Kernelamidopropyl Betaine, Polytetrafluoroethylene Acetoxypropyl Betaine, Ricinoleamidopropylbetaine, Sesamidopropylbetaine, Soyamidopropylbetaine, Stearamidopropylbetaine, Stearylbetaine, Tallowamidopropylbetaine, Tallowamidopropylhydroxysultaine, Tallowbetaine, Tallowdihydroxyethylbetaine, Undecylenamidopropylbetaine and Wheat Germamidopropyl Betaine.
- Suitable amine oxides are the following compounds named according to I NCI: Almondamidopropylamine Oxide, Babassuamidopropylamine Oxide, Behenamine Oxide, Cocamidopropyl Amine Oxide, Cocamidopropylamine Oxide, Cocamine Oxide, Coco-Morpholine Oxide, Decylamine Oxide, Decyltetradecylamine Oxide, Diaminopyrimidine Oxide, Dihydroxyethyl Cs-Cio Alkoxypropylamine Oxide, Dihydroxyethyl C9-C11 Alkoxypropylamine Oxide, Dihydroxyethyl C12-C15 Alkoxypropylamine Oxide, Dihydroxyethyl Cocamine Oxide, Dihydroxyethyl Lauramine Oxide, Dihydroxyethyl Stearamine Oxide, Dihydroxyethyl Tallowamine Oxide, Hydrogenated Palm Kernel Amine Oxide, Hydrogenated Tallowamine Oxide, Hydroxyethyl Hydroxyprop
- Illustrative alkylamidoalkylamines are the following compounds named according to I NCI: Cocoamphodipropionic Acid, Cocobetainamido Amphopropionate, DEA-Cocoamphodipropionate, Disodium Caproamphodiacetate, Disodium Caproamphodipropionate, Disodium Capryloamphodiacetate, Disodium Capryloamphodipropionate, Disodium Cocoamphocarboxyethylhydroxypropylsulfonate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Disodium Isostearoamphodiacetate, Disodium Isostearoamphodipropionate, Disodium Laureth-5 Carboxyamphodiacetate, Disodium Lauroamphodiacetate, Disodium Lauroamphodipropionate, Disodium Oleoamphodipropionate, Disodium PPG-2- lsodeceth-7 Carbox
- Illustrative alkyl-substituted amino acids are the following compounds named according to I NCI : Aminopropyl Laurylglutamine, Cocaminobutyric Acid, Cocaminopropionic Acid, DEA-Lauraminopropionate, Disodium Cocaminopropyl Iminodiacetate, Disodium Dicarboxyethyl Cocopropylenediamine, Disodium Lauriminodipropionate, Disodium Steariminodipropionate, Disodium Tallowiminodipropionate, Lauraminopropionic Acid, Lauryl Aminopropylglycine, Lauryl Diethylenediaminoglycine, Myristaminopropionic Acid, Sodium C12-C15 Alkoxypropyl Iminodipropionate, Sodium Cocaminopropionate, Sodium Lauraminopropionate, Sodium Lauriminodipropionate, Sodium Lauroyl Methylaminopropionate, TEA-
- the personal care or home care composition may, for example, comprise from 0.5 wt.- % to 20 wt.-%, preferably from 1 wt.-% to 10 wt.-%, more preferably from 2 wt.-% to 5 wt.-% amphoteric or zwitterionic surfactant.
- the personal care or home care composition of the invention comprises a total amount of surfactant of from 0.01 wt.-% to 70 wt.-%, preferably from 0.1 wt.-% to 40 wt.-%, more preferably from 1 wt.-% to 30%, particularly preferably from 2 wt.-% to 20 wt.-%.
- the personal care or home care composition of the present invention may also comprise a glosser.
- glossers include silicones.
- silicones are volatile or nonvolatile nonionic silicone fluids, silicone resins, and silicone semisolids or solids.
- Volatile silicones are linear or cyclic silicones having a measurable vapor pressure, which is defined as a vapor pressure of at least 2 mm of mercury at 20°C.
- water insoluble nonvolatile silicone fluids including polyalkyl siloxanes, polyaryl siloxanes, polyalkylaryl siloxanes, polyether siloxane copolymers, amine-functional silicones, or mixtures thereof.
- the personal care or home care composition of the invention may contain from 0.05 to 5%, preferably from 0.5 to 5% by weight of at least one oil component.
- Typical oils are organic oils, which often are esters.
- the oil component may comprise glyceryl esters of fatty acids, or triglycerides, coconut oil, almond oil, apricot kernel oil, avocado oil, babassu oil, evening primrose oil, camelina sativa seed oil, grape seed oil, macadamia ternifolia seed oil, corn oil, meadowfoam seed oil, mink oil, olive oil, palm kernel oil, safflower oil, sesame oil, soybean oil, sunflower oil, wheat germ oil, and camellia reticulata seed oil.
- the personal care or home care composition of the invention can contain from 0.1 to 10% by weight, preferably from 0.2 to 5% by weight, more preferably from 0.2 to 3% by weight, also more preferably from 0.5 to 5% by weight of at least one rheology modifying agent, in particular a gelling and thickening agent.
- cellulosic thickeners for example, hydroxyethylcellulose, hydroxypropylcellulose, and carboxymethylcellulose, guar gum, such as hydroxypropylguar, gums of microbial origin, such as xanthan gum and scleroglucan gum, and synthetic thickeners, such as crosslinked homo- or copolymers of acrylic acid and/or of acrylamidopropanesulphonic acid.
- rheology modifying agents include fatty acid amides such as coconut diethanolamide and monoethanolamide, and oxyethylenated monoethanolamide of carboxylic acid alkyl ether.
- Rheology modifying agents are also known as structuring materials.
- Common structuring materials include polymeric materials known as “carbomers”, including, for example, the cross-linked polyacrylic acid polymers available from Lubrizol Corporation under the trademark Carbopol®.
- Another class of (meth)acrylic acid polymers are alkali- swellable emulsion (ASE) polymers.
- ASE polymers include, for example, Aculyn® 38 copolymer from Dow.
- Carbomers and ASE polymers belong to a class of materials known as hydrodynamic thickeners. These hydrodynamic thickeners include acid groups in their polymeric structure that, when deprotonated, form anionic charges that repel each other, causing the polymer chains to expand and entangle.
- Expansion and chain entanglement can give rise to thickening and suspending effects provided by the deprotonated polymers.
- the properties of these hydrodynamic thickeners are impacted by their molecular weight, acid group content, degree of cross-linking, and extent of swelling. These thickeners are also known as "space filling” or “volume excluding” and tend to increase both viscosity and yield point as the concentration thereof is increased.
- hydrodynamic polymers commonly give rise to compositions that exhibit shear thinning or non-Newtonian behavior.
- Another class of (meth)acrylic acid-based rheology modifiers are hydrophobically modified alkali swellable (HASE) polymers.
- the HASE polymers include acid groups, the deprotonation of which gives rise to polymer swelling. Additionally, the HASE polymers include hydrophobic side groups, chains or blocks that give rise to associative interactions with each other, as well as with other hydrophobic species present in the compositions in which they are employed, for example, hydrophobic groups of surfactants, fatty acids, other thickening agents, and the like. Association creates hydrophobic regions distributed throughout the polymer chain network. This can also help to enhance the properties of the materials as solubilizing agents. Aculyn® 22 and Aculyn® 28 copolymers from Dow and Aqua SF 1® copolymer from Lubrizol Corporation are among the commonly used HASE materials. U.S.
- Patent 4,529,773 reports alkali-soluble emulsion polymers activated by neutralization to a pH above 6.5, and subsequently acidified in the presence of a surfactant. These are described as useful thickeners in acidic compositions.
- the polymers are formed from the copolymerization of a monomer system that includes: (1) methacrylic or acrylic acid, (2) methacrylic or acrylic acid ester of a C8-C30 alkyl or, as therein more particularly described, a hydrocarbyl monoether of polyethylene glycol, (3) a C1-C4 alkyl acrylate or methacrylate, and, optionally, (4) a small amount of a polyethylenically unsaturated monomer.
- a monomer system that includes: (1) methacrylic or acrylic acid, (2) methacrylic or acrylic acid ester of a C8-C30 alkyl or, as therein more particularly described, a hydrocarbyl monoether of polyethylene glycol, (3) a C1-C4 alkyl acrylate or methacrylate, and, optionally, (4) a small amount of a polyethylenically unsaturated monomer.
- the amount of rheology modifying agent if it is not 0%, is preferably up to 5% by weight, more preferably from 0.1% to 3% by weight, especially preferably from 0.5% to 2.5% by weight and exceptionally preferably from 1 % to 2% by weight, based on the total weight of the personal care or home care composition. In at least one embodiment, the amount of rheology modifying agent, if it is not 0%, is preferably up to 0.5% by weight, more preferably from 0.001% to 0.3% by weight, especially preferably from 0.01% to 0.2% by weight and exceptionally preferably from 0.01% to 0.15% by weight, based on the total weight of the personal care or home care composition.
- the composition has a viscosity of from 0 cPs to 20,000 cPs. In at least one embodiment, the composition has a viscosity of from 0.1 cPs to 10,000 cPs, or from 1 cPs to 5,000 cPs, or from 5 cPs to 3,500 cPs. It is understood that the components disclosed can in some instances fall into more than one classification, e.g., some fatty alcohol derivatives can also be classified as fatty acid derivatives. However, a given classification is not intended to be a limitation on that particular compound but is done so for convenience of classification and nomenclature.
- fatty alcohols have 14 to 30 or 16 to 22 carbon atoms. These fatty alcohols are saturated and can be linear or branched. Examples of fatty alcohols are cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof. Preferred fatty acids have from 10 to 30 or from 12 to 22 carbon atoms. These fatty acids can be saturated and can be linear or branched. Also included herein are salts of these fatty acids. Examples of fatty acids are lauric acid, palmitic acid, stearic acid, behenic acid, sebacic acid, or mixtures thereof. In a preferred embodiment, the personal care or home care composition comprises a solvent selected from the group consisting of water, glycols, ethanol, and combinations thereof.
- the personal care or home care composition comprises an aqueous, alcoholic or aqueous-alcoholic solvent, wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1 ,2-propylene glycol, 1 ,3-propylene glycol, isobutanol, butanol, butyl glycol, butyl diglycol, glycerol, or a mixture thereof; preferably wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, ethanol, propanol, isopropanol, 1 ,2- propylene glycol, 1 ,3-propylene glycol, glycerol, or mixtures thereof; more preferably wherein the aqueous, alcoholic or aqueous-alcoholic solvent comprises water, isopropanol, 1 ,2-propylene glycol, 1 ,3-propylene glycol, or mixtures thereof; even more
- the personal care or home care composition comprises a solvent selected from the group consisting of plant oil, honey, plant-derived sugar compositions, and mixtures thereof.
- the personal care or home care composition comprises at least one additive common in the field of cosmetology, pharmacy, and dermatology, which are hereinafter called auxiliaries.
- the composition comprises an auxiliary.
- the auxiliary is cosmetically acceptable.
- the auxiliary is selected from the group consisting of waxes, surfactants, cationic polymers, film formers, superfatting agents, refatting agents, foam stabilizers, stabilizers, active biogenic substances, preservatives, preservation boosting ingredients, anti-fungal substances, anti-dandruff agents, dyes or pigments, particulate substances, opacifiers, abrasives, absorbents, anticaking agents, bulking agents, pearlizing agents, direct dyes, perfumes or fragrances, carriers, solvents or diluents, propellants, functional acids, active ingredients, skin-brightening agents, self-tanning agents, exfoliants, enzymes, anti-acne agents, deodorants and anti-perspirants, viscosity modifiers, thickening and gelling agents, pH adjusting agents, buffering agents, anti-oxidants, chelants, astringents, sunscreens, sun protection agents, UV filters, conditioning agents (for example hair conditioning agents or skin
- the personal care or home care composition comprises water soluble vitamins and their derivatives, water soluble amino acids and their salts and/or derivatives, viscosity modifiers, dyes, nonvolatile solvents or diluents (water soluble and insoluble), pearlescent aids, thickeners, foam boosters, additional surfactants or nonionic co-surfactants, pediculocides, pH adjusting agents, perfumes, preservatives, chelants, proteins, skin active agents, sunscreens, UV absorbers, vitamins, niacinamide, caffeine, minoxidil, and combinations thereof.
- the personal care composition comprises from 0 wt.-% to 5 wt.-% vitamins and amino acids, by total weight of the composition.
- the personal care or home care composition may also comprise pigment materials such as inorganic, nitroso, monoazo, disazo, carotenoid, triphenyl methane, triaryl methane, xanthene, quinoline, oxazine, azine, anthraquinone, indigoid, thionindigoid, quinacridone, phthalocyanine, botanical, natural colors, including: water soluble components such as those having C.l. Names.
- the personal care or home care composition may comprise from 0 wt.-%, preferably from 0.0001 wt.-% to 5 wt.-% pigment materials.
- the personal care or home care composition comprises an oily substance, which is any fatty substance which is liquid at room temperature (25°C).
- the personal care or home care composition comprises an oily substance selected from the group consisting of silicone oils, volatile or nonvolatile, linear, branched or cyclic, optionally with organic modification; phenylsilicones; silicone resins and silicone gums; mineral oils such as paraffin oil or vaseline oil; oils of animal origin such as perhydrosqualene, lanolin; oils of plant origin such as liquid triglycerides, e.g., sunflower oil, corn oil, soybean oil, rice oil, jojoba oil, babusscu oil, pumpkin oil, grapeseed oil, sesame oil, walnut oil, apricot oil, macadamia oil, avocado oil, sweet almond oil, lady’s-smock oil, castor oil, triglycerides of caprylic/capric acids, olive oil, peanut oil, rapeseed oil,
- the personal care or home care composition comprises a nonionic coemulsifier.
- the nonionic coemulsifier is selected from adducts of from 0 to 30 mol of ethylene oxide and/or from 0 to 5 mol of propylene oxide with linear fatty alcohols having 8 to 22 carbon atoms, with fatty acids having 12 to 22 carbon atoms, with alkylphenols having 8 to 15 carbon atoms in the alkyl group, and with sorbitan or sorbitol esters; (C12-C18) fatty acid monoesters and diesters of adducts of from 0 to 30 mol of ethylene oxide with glycerol; glycerol monoesters and diesters and sorbitan monoesters and diesters of saturated and unsaturated fatty acids having 6 to 22 carbon atoms and, where appropriate, their ethylene oxide adducts; adducts of from 15 to 60 mol of ethylene oxide with cast
- suitable are mixtures of compounds from one or more of these classes of substance.
- suitable ionogenic coemulsifiers include anionic emulsifiers, such as mono-, di- or tri-phosphoric esters, but also cationic emulsifiers such as mono- , di-, or tri-alkyl quats and their polymeric derivatives.
- the personal care or home care composition comprises a cationic polymer.
- Suitable cationic polymers include those known under the INCI designation “Polyquaternium”, especially Polyquaternium-31 , Polyquaternium-16, Polyquaternium-24, Polyquaternium-7, Polyquaternium-22, Polyquaternium-39, Polyquaternium-28, Polyquaternium-2, Polyquaternium-10, Polyquaternium-11 , and also Polyquaternium 37 & mineral oil & PPG trideceth (Salcare SC95), PVP-dimethylaminoethyl methacrylate copolymer, guar-hydroxypropyltriammonium chlorides, and also calcium alginate and ammonium alginate.
- Polyquaternium especially Polyquaternium-31 , Polyquaternium-16, Polyquaternium-24, Polyquaternium-7, Polyquaternium-22, Polyquaternium-39, Polyquaternium-28, Polyquaternium-2, Polyquaternium-10, Polyquaternium-11
- cationic cellulose derivatives cationic starch; copolymers of diallylammonium salts and acrylamides; quaternized vinylpyrrolidone/vinylimidazole polymers; condensation products of polyglycols and amines; quaternized collagen polypeptides; quaternized wheat polypeptides; polyethyleneimines; cationic silicone polymers, such as amidomethicones, for example; copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine; polyaminopolyamide and cationic chitin derivatives, such as chitosan, for example.
- the personal care or home care composition comprises a superfatting agent.
- superfatting agents it is possible to use substances such as, for example, polyethoxylated lanolin derivatives, lecithin derivatives, polyol fatty acid esters, monoglycerides, and fatty acid alkanol amides, the latter serving simultaneously as foam stabilizers.
- Moisturizers available include, for example, isopropyl palmitate, glycerol and/or sorbitol.
- the personal care or home care composition comprises a care additive.
- the personal care or home care composition can be blended with conventional ceramides, pseudoceramides, fatty acid N-alkylpolyhydroxyalkyl amides, cholesterol, cholesterol fatty acid esters, fatty acids, triglycerides, cerebrosides, phospholipids, panthenol, and similar substances as a care additive.
- Functional acids are acidic substances used to impart a clinical functionality to the skin or hair upon application. Suitable functional acids include alpha hydroxy acids, beta- hydroxy acids, lactic acid, retinoic acid, and similar substances.
- the personal care or home care composition comprises an astringent.
- the astringent is selected from the group consisting of magnesium oxide, aluminium oxide, titanium dioxide, zirconium dioxide, zinc oxide, oxide hydrates, aluminium oxide hydrate (boehmite) and hydroxide, chlorohydrates of calcium, magnesium, aluminium, titanium, zirconium or zinc.
- the personal care or home care composition comprises from 0.001 wt.-% to 10 wt.-%, or from 0.01 wt.-% to 9 wt.-%, or from 0.05 wt.-% to 8 wt.-%, or from 0.1 wt.-% to 5 wt.-% astringent.
- the personal care composition comprises a deodorising agent.
- the deodorising agent is selected from the group consisting of allantoin, bisabolol, and combinations thereof.
- the personal care composition comprises from 0.001 wt.-% to 10 wt.-%, or from 0.01 wt.-% to 9 wt.-%, or from 0.05 wt.-% to 8 wt.-%, or from 0.1 wt.-% to 5 wt.-% deodorising agent.
- the personal care composition comprises a sun protection agent and/or UV filter.
- Suitable sun protection agents and UV filters are disclosed in WO-2013/017262A1 , from page 32, line 11 to the end of page 33.
- the sun protection agent and/or UV filter is selected from the group consisting of 4-amino benzoic acid, 3-(4'-trimethylammonium)- benzylide-boran-2-one-methylsulfate, camphor benzalkonium methosulfate, 3,3,5- trimethyl-cyclohexylsalicylate, 2-hydroxy-4-methoxybenzophenone, 2-phenylbenzimidazole-5-sulfonic acid and potassium-, sodium- und triethanolamine salts thereof, 3,3 ' -(1 ,4-phenylene dimethine)-bis-(7,7- dimethyl-2- oxobicyclo[2.2.1]-heptane-1 -methane sulfonic acid) and
- the personal care composition comprises from 0.001 wt.-% to 10 wt.-%, preferably from 0.05 wt.-% to 5 wt.-%, even more preferably from 0.1 wt.-% to 3 wt.-%, most preferably from 0.05 wt.-% to 1 wt.-% sun protection agent and/or UV filter.
- the personal care composition comprises a photoprotective substance in an amount of from 0.01 to 10 wt.-%, or from 0.1 to 5 wt.-%, more preferably from 0.2 to 2 wt.-%.
- Suitable photoprotective substances include, in particular, all of the photoprotective substances specified in EP1084696A1 (L’OREAL), which is incorporated herein by reference.
- the photoprotective substance is selected from the group consisting of 2-ethylhexyl 4-methoxycinnamate, methyl methoxycinnamate, 2-hydroxy-4- methoxybenzophenone-5-sulfonic acid, polyethoxylated p-aminobenzoates, and combinations thereof.
- the personal care or home care composition comprises an anti-oxidant.
- the anti-oxidant is selected from the group consisting of amino acids, peptides, sugars, imidazoles, carotinoids, carotenes, chlorogenic acid, lipoic acid, thiols, thiol glycosyl esters, thiol N-acetyl esters, thiol methyl esters, thiol ethyl esters, thiol propyl esters, thiol amyl esters, thiol butyl esters, thiol lauryl esters, thiol palmitoyl esters, thiol oleyl esters, thiol linoleyl esters, thiol cholesteryl esters, thiol glyceryl esters, dilaurylthiodipropionate, distearylthiodipropionate, thiodipropi
- the anti-oxidant is selected from the group consisting of glycine, histidine, tyrosine, tryptophan, urocaninic acid, D,L- carnosine, D-carnosine, L-carnosine, beta-carotene, alpha-carotene, lycopene, dihydrolipoic acid, aurothioglucose, propylthiouracil, thioredoxine, glutathione, cysteine, cystine, cystamine, buthioninsulfoximine, homocysteinsulfoximine, buthioninsulfone, penta-, hexa-, heptathioninsulfoximine, hydroxyfatty acids, palmitic acid, phytinic acid, lactoferrin, citric acid, lactic acid, malic acid, humic acid, bile acid, bilirubin, biliverdin, EDTA, EGTA, linoleic acid
- the antioxidant is selected from the group consisting of vitamin A, vitamin A derivatives, vitamin E, vitamin E derivatives, and combinations thereof.
- the personal care composition comprises from 0.001 wt.-% to 10 wt.-%, preferably from 0.05 wt.-% to 5 wt.-%, even more preferably from 0.1 wt.-% to 3 wt.-%, most preferably from 0.05 wt.-% to 1 wt.-% antioxidant.
- the personal care or home care composition comprises from 0.01 wt.-% to 10 wt.-%, preferably from 0.05 wt.-% to 5 wt.-%, of at least one particulate substance.
- suitable substances are, for example, substances which are solid at room temperature (25°C) and are in the form of particles.
- the particulate substance is selected from the group consisting of silica, silicates, aluminates, clay earths, mica, insoluble salts, in particular insoluble inorganic metal salts, metal oxides, e.g. titanium dioxide, minerals and insoluble polymer particles are suitable.
- the particles may be present in the personal care or home care composition in undissolved, preferably stably dispersed form, and, following application to the keratin substrate and evaporation of the solvent, can deposit on the substrate in solid form.
- a stable dispersion can be achieved by providing the personal care or home care composition with a yield point which is large enough to prevent the solid particles from sinking. An adequate yield point can be established using suitable gel formers in a suitable amount.
- the particulate substance is selected from the group consisting of silica (silica gel, silicon dioxide) and metal salts, in particular inorganic metal salts, where silica is particularly preferred.
- Metal salts are, for example, alkali metal or alkaline earth metal halides, such as sodium chloride or potassium chloride; alkali metal or alkaline earth metal sulfates, such as sodium sulfate or magnesium sulfate.
- additional disinfectants and/or preservatives suitable in accordance with the invention are, for example, active anti-microbial ingredients from the groups of the alcohols, aldehydes, anti-microbial acids and salts thereof, carboxylic esters, acid amides, phenols, phenol derivatives, diphenyls, diphenylalkanes, urea derivatives, oxygen and nitrogen acetals and formals, benzamidines, isothiazoles and derivatives thereof such as isothiazolines and isothiazolinones, phthalimide derivatives, pyridine derivatives, anti-microbial surface-active compounds, guanidines, anti-microbial amphoteric compounds, quinolines, 1 ,2-dibromo-2,4-dicyanobutane, iodo-2-propynyl butyl carbamate, iodine, iodophors and peroxides.
- active anti-microbial ingredients from the groups of the alcohols, al
- Preferred active anti-microbial ingredients are preferably selected from the group comprising ethanol, n-propanol, i- propanol, butane-1, 3-diol, phenoxyethanol, 1 ,2-propylene glycol, glycerol, undecylenoic acid, citric acid, lactic acid, benzoic acid, salicylic acid, thymol, 2-benzyl-4-chlorophenol, 2,2'-methylenebis(6-bromo-4-chlorophenol), 2,4,4'-trichloro-2'-hydroxydiphenyl ether, N- (4-chlorophenyl)-N-(3,4-dichlorophenyl)urea, N,N'-(1 , 10-decanediyldi-1 -pyridinyl-4- ylidene)bis(l-octanamine) dihydrochloride, N,N'-bis(4-chlorophenyl)-3,12-diimin
- Preferred anti-microbial surface-active quaternary compounds contain an ammonium, sulfonium, phosphonium, iodonium or arsonium group, as described, for example, by K. H. Wallatorir in "Praxis der Sterilisation, Desinfetechnisch - Konservtechnik: Keimidentiser - Racegiene” [Practical Sterilization, Disinfection - Preservation: Microbe Identification - Commercial Hygiene] (5th edition - Stuttgart; New York: Thieme, 1995).
- the personal care or home care composition comprises a conditioning agent.
- the conditioning agent is a water insoluble, water dispersible, non-volatile, liquid that forms emulsified, liquid particles.
- the conditioning agent is a silicone (e.g., silicone oil, cationic silicone, silicone gum, high refractive silicone, and silicone resin), an organic conditioning oil (e.g., hydrocarbon oils, polyolefins, and fatty esters), a cationic conditioning surfactant, a high melting point fatty compound, or combinations thereof.
- the conditioning agent is a silicone.
- the personal care or home care composition comprises from 0.01 % to 10 %, or from 0.1 % to 5 % silicone conditioning agent, by total weight of the composition. Suitable silicone conditioning agents, and optional suspending agents for the silicone, are described in US-5,104,646.
- the composition comprises a silicone gum selected from the group consisting of polydimethylsiloxane, (polydimethylsiloxane) (methylvinylsiloxane) copolymer, poly(dimethylsiloxane) (diphenylsiloxane) (methylvinylsiloxane) copolymer, and mixtures thereof.
- the personal care or home care composition comprises a terminal aminosilicone.
- Terminal aminosilicone as defined herein means silicone comprising one or more amino groups at one or both ends of the silicone backbone.
- the personal care or home care composition is substantially free of any silicone compound comprising pendant amino groups.
- the personal care or home care composition is substantially free of any silicone compound other than terminal aminosilicones.
- the amino group at at least one terminus of the silicone backbone of the terminal aminosilicone is selected from the group consisting of primary amines, secondary amines and tertiary amines.
- the personal care or home care composition comprises a terminal aminosilicone conforming to Formula (S):
- G is hydrogen, phenyl, hydroxy, or Ci-Cs alkyl, preferably methyl; a is an integer having a value from 1 to 3, preferably 1 ; b is 0, 1 or 2, preferably 1 ; n is a number from 0 to 1999;
- R F is a monovalent radical conforming to the general formula C q H 2q L, wherein q is an integer having a value from 2 to 8 and L is selected from the following groups: -N(R T )CH 2 -CH 2 -N(R T ) 2 ; -N(R T ) 2 ; -N(R T ) 3 A ;
- R T is hydrogen, phenyl, benzyl, or a saturated hydrocarbon radical, preferably an alkyl radical from having from 1 to
- A is a halide ion.
- a suitable terminal aminosilicone corresponding to Formula (S) has a
- n is from 100 to 1500, or from 200 to 800
- L is selected from the following groups: -N(R T )CH 2 -CH 2 -N(R T ) 2 ; -N(R T ) 2 ; -N(R T ) 3 A ; -N(R T )CH 2 -CH 2 -NR T H 2 A ; wherein R T is hydrogen, phenyl, benzyl, or a saturated hydrocarbon radical, preferably an alkyl radical having from 1 to 20 carbon atoms; A is a halide ion, alternatively L is - NH 2 .
- the terminal aminosilicone is selected from the group consisting of bis-aminomethyl dimethicone, bis-aminoethyl dimethicone, bis- aminopropyl dimethicone, bis-aminobutyl dimethicone, and mixtures thereof.
- the viscosity of the terminal aminosilicone is from 1 ,000 to 30,000 cPs, or from 5,000 to 20,000 cPs, measured at 25°C.
- the personal care or home care composition comprises from 0.1 % to 20 %, or from 0.5 % to 10 %, or from 1 % to 6 % terminal aminosilicone, by total weight of the composition.
- the personal care or home care composition comprises a high melting point fatty compound.
- the high melting point fatty compound has a melting point of 25°C or higher.
- the high melting point fatty compound is selected from the group consisting of a fatty alcohol, fatty acid, fatty alcohol derivative, fatty acid derivative, and mixtures thereof.
- Non-limiting examples of the high melting point compounds are found in International Cosmetic Ingredient Dictionary, Fifth Edition, 1993, and CTFA Cosmetic Ingredient Handbook, Second Edition, 1992.
- the composition may comprise from 0.1 % to 40 %, or from 1 % to 30 %, or from 1.5 % to 16 %, or from 1.5 % to 8 % of a high melting point fatty compound, by total weight of the composition.
- the fatty alcohol is selected from the group consisting of: cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixtures thereof.
- the personal care or home care composition comprises a linear fatty alcohol, wherein the linear fatty alcohol is comprised in a lamellar gel matrix.
- a lamellar gel matrix is suitable for providing various conditioning benefits such as slippery feel during the application to wet hair and softness and moisturized feel on dry hair.
- the linear fatty alcohol may comprise from 8 to 24 carbon atoms.
- the linear fatty alcohol is selected from the group consisting of: cetyl alcohol, stearyl alcohol, and mixtures thereof.
- the weight ratio of total linear fatty alcohol to terminal aminosilicone is from 0.5:1 to 10:1 , or from 1 :1 to 5:1 , or from 2.4:1 to 2.7:1.
- the lamellar gel matrix comprises a cationic conditioning surfactant and a high melting point fatty compound.
- the cationic conditioning surfactant and the high melting point fatty compound are contained at a level such that the weight ratio of the cationic surfactant to the high melting point fatty compound is in the range of from 1 :1 to 1 : 10, or from 1 :1 to 1 :6.
- the personal care or home care composition comprises a cationic conditioning surfactant.
- the personal care or home care composition comprises from 0.05 % to 3.0 %, or from 0.075 % to 2.0 %, or from 0.1 % to 1.0 %, of cationic conditioning surfactant by total weight of the composition.
- the cationic conditioning surfactant is comprised in a lamellar gel matrix.
- the personal care or home care composition comprises a lamellar gel matrix and the lamellar gel matrix comprises the cationic conditioning surfactant.
- the cationic conditioning surfactant is according to Formula (C): wherein at least one of R 71 , R 72 , R 73 and R 74 is selected from an aliphatic group of from 8 to 30 carbon atoms, an aromatic, alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl, or an alkylaryl group having up to 22 carbon atoms; the remainder of R 71 , R 72 , R 73 and R 74 are independently selected from the group consisting of an aliphatic group having from 1 to 22 carbon atoms, and an aromatic, alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl or alkylaryl group having up to 22 carbon atoms;
- X is selected from the group consisting of: halogen, acetate, citrate, lactate, glycolate, phosphate, nitrate, sulfonate, sulfate, alkylsulfate, alkyl sulfonate radicals, and combinations thereof.
- the cationic conditioning surfactant is selected from the group consisting of behenyl trimethyl ammonium chloride, methyl sulfate or ethyl sulfate, and stearyl trimethyl ammonium chloride, methyl sulfate or ethyl sulfate.
- a longer alkyl group provides improved smoothness and soft feeling on wet and dry hair, compared to cationic surfactants with a shorter alkyl group. It is also believed that such cationic surfactants can provide reduced irritation, compared to those having a shorter alkyl group.
- the cationic surfactant is a di-long alkyl quatemized ammonium salt selected from the group consisting of: dialkyl (C14-C18) dimethyl ammonium chloride, ditallow alkyl dimethyl ammonium chloride, dihydrogenated tallow alkyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dicetyl dimethyl ammonium chloride, and mixtures thereof.
- the cationic surfactant is a tertiary amido amine having an alkyl group of from 12 to 22 carbons.
- the tertiary amido amine may be selected from the group consisting of stearamidopropyldimethyl-, stearamidopropyldiethyl-, stearamidoethyldiethyl-, stearamidoethyldimethyl-, palmitamidopropyldimethyl-, palmitamidopropyldiethyl-, palmitamidoethyldiethyl-, palmitamidoethyldimethyl-, behenamidopropyldimethyl-, behenamidopropyldiethyl-, behenamidoethyldiethyl-, behenamidoethyldimethyl-, arachidamidopropyldimethyl-, arachidamidopropyldiethyl-,
- a tertiary amido amine may be used in combination with an acid.
- the acid is typically used as a salt-forming anion.
- the acid is selected from the group consisting of lactic acid, malic acid, hydrochloric acid, 1-glumatic acid, acetic acid, citric acid, and mixtures thereof.
- the cationic surfactant is selected from the group consisting of cetyltrimonium chloride (CTAC), stearyltrimonium chloride (STAC), behentrimonium methosulfate, stearoylamidopropyldimethyl amine (SAPDMA), distearyldimethylammonium chloride, and mixtures thereof.
- CTAC cetyltrimonium chloride
- STAC stearyltrimonium chloride
- SAPDMA stearoylamidopropyldimethyl amine
- distearyldimethylammonium chloride distearyldimethylammonium chloride
- the home care composition of the invention may comprise one or more corrosion inhibitors.
- Suitable corrosion inhibitors are, for example, the following substances named according to INCI: Cyclohexylamine, Diammonium Phosphate, Dilithium Oxalate, Dimethylamino Methylpropanol, Dipotassium Oxalate, Dipotassium Phosphate, Disodium Phosphate, Disodium Pyrophosphate, Disodium Tetrapropenyl Succinate, Hexoxyethyl Diethylammonium, Phosphate, Nitromethane, Potassium Silicate, Sodium Aluminate, Sodium Hexametaphosphate, Sodium Metasilicate, Sodium Molybdate, Sodium Nitrite, Sodium Oxalate, Sodium Silicate, Stearamidopropyl Dimethicone, Tetrapotassium Pyrophosphate, Tetrasodium Pyrophosphate and Triiso
- the personal care or home care composition of the present invention may further comprise fragrances.
- Fragrances which may be used are individual odorant compounds, e.g. the synthetic products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon types.
- Odorant compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethylphenyl glycinate, allyl cyclohexyl propionate, styrallyl propionate and benzyl salicylate.
- the ethers include, for example, benzyl ethyl ethers
- the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, hydroxycitronellal, lilial and bourgeonal
- the ketones include, for example, the ionones, alpha-isomethylionone and methyl cedryl ketone
- the alcohols include anethol, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol
- the hydrocarbons include primarily the terpenes and balsams.
- Fragrances used may also be natural odorant mixtures, as obtainable from vegetable or animal sources, e.g. pine oil, citrus oil, jasmine oil, lily oil, rose oil or ylang-ylang oil.
- Essential oils of relatively low volatility, which are usually used as aroma components, are also suitable as perfume oils, for example sage oil, chamomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil and ladanum oil.
- the amount of the fragrances in the personal care or home care composition of the present invention is preferably from 0.001% to 2% by weight and more preferably from 0.01% to 2% by weight, based on the total weight of the personal care or home care composition.
- any dyes and pigments optionally present in the personal care or home care composition of the invention may be selected from the corresponding positive list from the Cosmetics Directive or the EU list of cosmetic colorants.
- pearlescent pigments e.g. pearl essence (mixed guanine/hypoxanthine crystals from fish scales) and mother of pearl (ground seashells)
- monocrystalline pearlescent pigments for example bismuth oxychloride (BiOCI)
- layer-substrate pigments e.g.
- the amount of the dyes and pigments in the personal care or home care composition of the invention if it is not 0%, is preferably from 0.01% to 1.0% by weight, based on the total weight of the personal care or home care composition.
- the personal care or home care composition comprises an alkalizing agent or pH adjusting agent.
- ammonia or caustic soda is suitable, but water-soluble, physiologically tolerable salts of organic and inorganic bases can also be considered.
- the pH adjusting agent is selected from ammonium hydrogen carbonate, ammonia, monoethanolamine, ammonium carbonate.
- the alkalizing agent is selected from the group consisting of 2-amino-2-methyl-1 -propanol, 2-amino-2-methyl-1 ,3- propanediol, 2-amino-2-ethyl-1 , 3-propanediol, tris(hydroxyl-methyl)-aminomethane, 2- amino-1-butanole, tris-(2-hydroxypropyl)-amine, 2,2-iminobisethanol, lysine, iminourea (guanidine carbonate), tetrahydro-1 ,4-oxazine, 2-amino-5-guanidin-valeric acid, 2- aminoethansulfonic acid, diethanolamine, triethanolamine, N-methyl ethanolamine, isopropanolamine, diisopropanolamine, triisopropanolamine, glucamine, sodium hydroxide, potassium hydroxide, lithium hydroxide and magnesium oxide, and mixtures thereof.
- an acid can be included.
- the personal care or home care composition comprises an acid selected from the group consisting of hydrochloric acid, phosphoric acid, acetic acid, formic acid, sulfuric acid, hydrochloric acid, citric acid, and mixtures thereof.
- Citric acid is most preferred in that it has high consumer acceptance.
- the acidic pH is adjusted with a buffer such as a phosphate buffer, a TRIS buffer or a citric buffer.
- the buffers may be used alone or in combination with an acid.
- the home care composition of the invention may optionally comprise conventional ingredients commonly used in detergent compositions, especially laundry detergent compositions.
- optional ingredients include, but are not limited to, builders, bleaching agents, bleach active compounds, bleach activators, bleach catalysts, photobleaches, dye transfer inhibitors, colour protection agents, anti redeposition agents, dispersing agents, fabric softening agents, antistatic agents, fluorescent whitening agents, enzymes, enzyme stabilizing agents, foam regulators, defoamers, malodour reducers, preservatives, disinfecting agents, hydrotropes, fibre lubricants, anti-shrinkage agents, buffers, fragrances, processing aids, colorants, dyes, pigments, anti-corrosion agents, fillers, or stabilizers.
- polymer for detergency boosting, it may be advantageous to use a polymer in home care cleaning compositions, particularly in liquid laundry detergent compositions.
- This polymer is preferably a polyalkoxylated polyethyleneimine (EPEI).
- EPEI polyalkoxylated polyethyleneimine
- Polyethylene imines are materials composed of ethylene imine units -CH 2 CH 2 NH- and, where branched, the hydrogen on the nitrogen is replaced by another chain of ethylene imine units.
- These polyethyleneimines can be prepared, for example, by polymerizing ethyleneimine in the presence of a catalyst such as carbon dioxide, sodium bisulfite, sulfuric acid, hydrogen peroxide, hydrochloric acid, acetic acid, and the like. Specific methods for preparing these polyamine backbones are disclosed in US 2,182,306, US 3,033,746, US 2,208,095, US 2,806,839, and US 2,553,696.
- the home care cleaning compositions may comprise other polymeric materials, for example: dye transfer inhibition polymers, anti-redeposition polymers and cotton soil release polymers, especially those based on modified cellulosic materials.
- the formulation may further comprise a polymer of polyethylene glycol and vinyl acetate, for example the lightly grafted copolymers described in WO 2007/138054.
- amphiphilic graft polymers based on water soluble polyalkylene oxides as graft base and side chains formed by polymerisation of a vinyl ester component have the ability to enable reduction of surfactant levels whilst maintaining high levels of oily soil removal.
- the personal care or home care composition comprises a hydrotrope.
- hydrotrope is a solvent that is neither water nor conventional surfactant, and that aids the solubilisation of surfactants and other components, especially any polymer and/or sequestrant, in the liquid, to render it isotropic. Hydrotropes are particularly useful in home care cleaning compositions. Among suitable hydrotropes the following are noteworthy: monopropylene glycol (MPG), glycerol, sodium cumene sulfonate, ethanol, other glycols, e.g. dipropylene glycol, diethers and urea. MPG and glycerol are preferred hydrotropes.
- sequestrants are included in the compositions, particularly in the home care cleaning compositions.
- Preferred sequestrants include organic phosphonates, alkanehydroxy phosphonates and carboxylates, e.g. available under the DEQUEST trade mark from Thermphos.
- the preferred sequestrant level is less than 10 wt.-% and more preferably less than 5 wt.-%, by total weight of the composition.
- a particularly preferred sequestrant is HEDP (1-hydroxyethylidene-1 ,1-diphosphonic acid), for example sold as Dequest 2010.
- Dequest ® 2066 diethylenetriamine penta(methylene-phosphonic acid) or Heptasodium DTPMP).
- Complexing agents are ingredients able to complex and inactivate metal ions, in order to prevent their adverse effects on the stability or appearance of the compositions, for example cloudiness. It is firstly important to complex the calcium and magnesium ions of water hardness that are incompatible with numerous ingredients. The complexation of the ions of heavy metals such as iron or copper secondly delays the oxidative breakdown of the finished compositions. Moreover, the complexing agents promote detergent action.
- Suitable examples are the following complexing agents named according to INCI: Aminotrimethylene, Phosphonic Acid, Beta-Alanine Diacetic Acid, Calcium Disodium EDTA, Citric Acid, Cyclodextrin, Cyclohexanediamine Tetraacetic Acid, Diammonium Citrate, Diammonium EDTA, Diethylenetriamine Pentamethylene Phosphonic Acid, Dipotassium EDTA, Disodium Azacycloheptane Diphosphonate, Disodium EDTA, Disodium Pyrophosphate, EDTA, Etidronic Acid, Galactaric Acid, Gluconic Acid, Glucuronic Acid, HEDTA, Hydroxypropyl Cyclodextrin, Methyl Cyclodextrin, Pentapotassium Triphosphate, Pentasodium Aminotrimethylene Phosphonate, Pentasodium Ethylenediamine Tetramethylene Phosphonate, Pentasodium Pentetate, Pentas
- bleaches can be added to the home care compositions.
- Suitable bleaches include peroxides, peracids and/or perborates, particular preference being given to H2O2 ⁇
- the home care compositions of the invention may also comprise enzymes, preferably proteases, lipases, amylases, hydrolases and/or cellulases. They can be added to the home care compositions, in particular detergent compositions, in any form established in the prior art. In the case of detergent compositions in liquid or gel form, these especially include solutions of the enzymes, advantageously in maximum concentration, with a low water level and/or with added stabilizers.
- the enzymes can be encapsulated, for example by spray-drying or extrusion of the enzyme solution together with a preferably natural polymer or in the form of capsules, for example those in which the enzymes are enclosed as in a solidified gel or in those of the core-shell type in which an enzyme-containing core has been coated with a water-, air- and/or chemical- impervious protective layer.
- further active ingredients for example stabilizers, emulsifiers, pigments, bleaches or dyes.
- Capsules of this kind are applied by methods known per se, for example by agitated or roller granulation or in fluidized bed processes.
- granules of this kind have a low dust level, for example through application of polymeric film formers, and are storage-stable on account of the coating.
- enzyme stabilizers it is possible for enzyme stabilizers to be present in enzyme-containing home care compositions, in order to protect any enzyme present in a home care composition from damage, for example inactivation, denaturation or breakdown, for instance as a result of physical effects, oxidation or proteolytic cleavage.
- Suitable enzyme stabilizers are especially: benzamidine hydrochloride, borax, boric acids, boronic acids or the salts or esters thereof, in particular derivatives having aromatic groups, for instance substituted phenylboronic acids or the salts or esters thereof; peptide aldehydes (oligopolypeptides with a reduced C terminus), amino alcohols such as mono-, di-, triethanol- and - propanolamine and mixtures thereof, aliphatic carboxylic acids up to C12, such as succinic acid, other dicarboxylic acids or salts of the acids mentioned; and end group- capped fatty acid amide alkoxylates; lower aliphatic alcohols and in particular polyols, for example glycerol, ethylene glycol, propylene glycol or sorbitol; and reducing agents and antioxidants such as sodium sulfite and reducing sugars.
- benzamidine hydrochloride borax, boric acids, boronic acids or the salt
- stabilizers for example the combination of polyols, boric acid and/or borax, the combination of boric acid or borate, reducing salts and succinic acid or other dicarboxylic acids, or the combination of boric acid or borate with polyols or polyamino compounds and with reducing salts.
- the personal care or home care composition particularly the liquid laundry detergent composition, comprises a buffer.
- a buffer In addition to agents optionally included for the generation of anionic surfactants, the presence of buffer is preferred for pH control.
- Possible buffers are one or more ethanolamines, e.g. monoethanolamine (MEA) or triethanolamine (TEA).
- compositions are preferably used in the composition at levels of from 1.0 to 15 wt.-%.
- suitable amino alcohol buffer materials may be selected from the group consisting of compounds having a molecular weight above 61 g/mol, which includes MEA. Suitable materials also include, in addition to the already mentioned materials: monoisopropanolamine, diisopropanolamine, triisopropanolamine, monoamino hexanol, 2-[(2-methoxyethyl)methylamino]- ethanol, propanolamine, N-methylethanolamine, diethanolamine, monobutanolamine, isobutanolamine, monopentanolamine, 1-amino-3-(2- methoxyethoxy)-2-propanol, 2-methyl-4-(methylamino)-2-butanol, and mixtures thereof.
- Potential alternatives to amino ethanol buffers are alkali hydroxides such as sodium hydroxide or potassium hydroxide.
- the home care composition is a hand dishwashing composition.
- the hand dishwashing composition comprises an anionic surfactant.
- the hand dishwashing composition comprises from 5 wt.-% to 25 wt.-% anionic surfactant.
- the hand dishwashing composition comprises a surfactant system comprising at least one anionic surfactant and a further surfactant selected from nonionic surfactants, amphoteric surfactants, or zwitterionic surfactants.
- the hand dishwashing composition comprises cocoamidopropylbetaine or an amine oxide.
- the amine oxide is lauryl amine oxide, cocoyl amine oxide, or a combination thereof.
- the pH value of the hand dishwashing composition is between pH 5.0 and pH 10, preferably from pH 5,5 to 9.0.
- the hand dishwashing composition preferably has a pH of between pH 7.5 and pH 9.5, most preferably from pH 8.0 to pH 9.0.
- the home care composition is a hard surface cleaner.
- the hard surface cleaner comprises an anionic surfactant.
- the hard surface cleaner comprises from 1 wt.-% to 10 wt.-% anionic surfactant.
- the hard surface cleaner comprises a nonionic surfactant.
- the hard surface cleaner comprises from 1 wt.-% to 10 wt.-% nonionic surfactant.
- the hard surface cleaner comprises a surfactant system comprising at least one anionic surfactant and a further surfactant selected from nonionic surfactants, amphoteric surfactants, zwitterionic surfactants, or combinations thereof.
- the hard surface cleaner comprises linear alkylbenzenesulfonate and fatty alcohol ethoxylate.
- the pH value of the hard surface cleaner is between pH 5.0 and pH 11 , preferably from pH 6.0 to pH 9.0.
- the home care composition is a liquid laundry detergent composition comprising one or more surfactants.
- the one or more surfactants of the liquid laundry detergent composition are selected from the group consisting of anionic, nonionic, cationic and zwitterionic surfactants, and more preferably from the group consisting of anionic, nonionic and zwitterionic surfactants.
- the one or more surfactants in the liquid laundry detergent composition are present in an amount of at least 5 wt.-%, more preferably from 5 wt.-% to 65 wt.-%, even more preferably from 6 to 60 wt.-%, and extraordinarily preferably from 7 wt.-% to 55 wt.-%, based on the total weight of the liquid laundry detergent composition.
- the personal care or home care composition is in liquid form.
- the personal care or home care composition is in solid form.
- the personal care or home care composition is in powdered or granulated form. This is advantageous in that it is not needed to ship liquid, which is typically heavy over long distances, which has economic and environmental benefits.
- a solid form can be achieved by spray drying the composition or the employment of a rotary evaporator.
- the personal care or home care composition can be converted into liquid form after it has been shipped, e.g. by adding water.
- Exemplary personal care formulations comprising the anti-microbial composition are given in Table 1 below.
- Table 1 Personal care formulations containing the anti-microbial composition
- Tables 2, 3 and 4 Exemplary home care formulations comprising the anti-microbial composition are given in Tables 2, 3 and 4 below.
- Table 2 Hand dish-washing compositions containing the anti-microbial composition
- Table 3 Hard surface cleaner compositions containing the anti-microbial composition
- Table 4 Laundry detergent compositions containing the anti-microbial composition
- V volume, in ml, of potassium thiocyanate 0.05N used for the sample
- F factor of potassium thiocyanate 0.05N used
- W weight of sample, in g
- the anti-microbial compositions E1-E6 were assayed for their silver oxide content and the results are given in Table 6 below.
- the value determined was the minimal inhibitory concentration (MIC) of anti-microbial agent necessary to reduce a known bacterial population to zero after a specified contact time. Depending on the plating out method used, a percentage kill can also be determined (if necessary) for each individual organism or set of organisms.
- the anti-microbial activity was tested in accordance with the BS EN1040. Principle
- a known aliquot of preservative was dosed into a weak nutrient solution and incubated with a known concentration of microbial species.
- the microbial species can be either mixed or single species bacteria, yeast or fungi. After determined time interval(s), an aliquot of sample was plated out using the spread plate method and the number of surviving species determined. By using a no-preservative treated control, the level at which preservative provided zero growth can be determined.
- a loopful of bacteria taken from an agar slope stored at 4°C was homogenised in 10ml tryptone soya broth and incubated (with shaking @150rpm) at 30°C ⁇ 2.5°C for 16h. After this period, the solution was adjusted using maximum recover diluent so that the solution contained approximately 5x10 5 viable cells/ml (An overnight culture contained approximately 1x10 9 cfu/ml, therefore the dilution required to produce the above inoculum level was calculated on this basis). The actual number in the exposure inoculum was determined using the standard spread plate count technique.
- a loopful of culture was removed from a malt extract agar slope stored at 4°C and homogenised in 10ml maximum recovery diluent. This was vortexed for 30 sec and the suspension was adjusted using maximum recover diluent so that the solution contained approximately 5x10 5 viable cells/ml. The actual number in the inoculum was determined using the standard spread plate count technique.
- Fungi were prepared by adding 10ml of 2% Tween solution to the malt extract slope stock cultures and vortexed for 30 sec. The suspension was adjusted using maximum recover diluent so that the solution contained approximately 5x10 5 viable spores/ml. The actual number in the inoculum was determined using the standard spread plate count technique. MIC detailed set up method
- Suitable temperatures for incubation of the test tubes were as follows:
- the kill rate was calculated in the following way:
- the MIC data for the anti-microbial composition is given in Table 8 below.
- Table 8 Minimum Inhibitory Concentration of the anti-microbial composition
- Personal care compositions comprising the anti-microbial composition of the present invention were made according to Tables 9 and 10 below.
- Example 18 - Home care compositions containing the anti-microbial composition Home care compositions comprising the anti-microbial composition of the present invention were made according to Tables 11 , 12 and 13 below.
- the data shows good efficacy of the anti-microbial composition against bacteria, yeast and fungi.
- the composition is also stable over a broad pH range of 2.6 to 9.0, and compatible in various formulations.
- the anti-microbial composition of E3 was used for studying the accelerated stability. Three samples of 50 g were drawn from E3 and kept at 40 ⁇ 2 °C temperature and 75 ⁇ 5% humidity. Stability was tested at 0, 1 , 3, and 6-month time intervals. The results are given in Table 15 below. Table 15
- the personal care and home care compositions comprising the anti-microbial composition of the present invention remain stable at room temperature as well as at accelerated stability conditions (as per Example 31) for three months with no change in appearance, viscosity or pH.
Abstract
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CN202280009587.5A CN116669687A (zh) | 2021-03-02 | 2022-02-28 | 抗微生物组合物 |
JP2023552537A JP2024512291A (ja) | 2021-03-02 | 2022-02-28 | 抗微生物組成物 |
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