WO2022174676A1 - Puce microfluidique, procédé et dispositif d'analyse d'urine et toilettes - Google Patents

Puce microfluidique, procédé et dispositif d'analyse d'urine et toilettes Download PDF

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Publication number
WO2022174676A1
WO2022174676A1 PCT/CN2021/142105 CN2021142105W WO2022174676A1 WO 2022174676 A1 WO2022174676 A1 WO 2022174676A1 CN 2021142105 W CN2021142105 W CN 2021142105W WO 2022174676 A1 WO2022174676 A1 WO 2022174676A1
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WIPO (PCT)
Prior art keywords
reagent
urine
reaction chamber
detection
microfluidic chip
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PCT/CN2021/142105
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English (en)
Chinese (zh)
Inventor
林鹤全
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杉木(深圳)生物科技有限公司
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Priority claimed from CN202110197739.6A external-priority patent/CN112834498A/zh
Priority claimed from CN202110197150.6A external-priority patent/CN112834497A/zh
Application filed by 杉木(深圳)生物科技有限公司 filed Critical 杉木(深圳)生物科技有限公司
Publication of WO2022174676A1 publication Critical patent/WO2022174676A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • E—FIXED CONSTRUCTIONS
    • E03—WATER SUPPLY; SEWERAGE
    • E03D—WATER-CLOSETS OR URINALS WITH FLUSHING DEVICES; FLUSHING VALVES THEREFOR
    • E03D9/00—Sanitary or other accessories for lavatories ; Devices for cleaning or disinfecting the toilet room or the toilet bowl; Devices for eliminating smells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value

Definitions

  • the present application relates to the technical field of detection, in particular to a microfluidic chip, a urine analysis method and device, and a toilet.
  • Urine test is a routine inspection item for medical institutions to examine patients. Through the analysis of patient's urine, the concentration of chemical components in urine can be obtained, such as glucose, urine protein, PH value, occult blood in urine , nitrite, bilirubin, urobilinogen, red blood cells, white blood cells, etc.
  • the concentration of chemical components in human urine has a normal range. When a patient develops a disease or changes their eating habits, the chemical composition in the urine will also change accordingly, so that the chemical composition in the patient's urine can be passed through. The concentration judges the health status of the patient.
  • the purpose of this application is to provide a microfluidic chip, a urine analysis method and device, and a toilet, and to provide a microfluidic chip with an optical detection function, the microfluidic chip can perform at least one measurement on a user's urine. It can analyze the user's urine on a daily basis, so that the user can view the analysis data of the urine and understand their own physical health.
  • the present application provides a microfluidic chip, comprising: a chip main body, an optical detection module fixed on the chip main body; a reaction cavity is formed in the chip main body and connected to the reaction cavity A plurality of reagent channels on the body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip body, the reaction chamber is also connected with a urine channel, and the urine channel is in the chip body A urine hole is formed on the upper part, and each of the reagent holes is used to install a reagent capsule; the reaction cavity is used for the urine flowing into the microfluidic chip through the urine channel and the urine in the reagent capsule.
  • the detection reagent reacts; the optical detection module is used to perform optical detection on the mixed liquid in the reaction chamber after the reaction between the urine and the detection reagent, to obtain detection data when the detection instruction is received.
  • the present application also provides a urine detection method, which is applied to the above-mentioned microfluidic chip.
  • the method includes: when a detection instruction is received, a detection reagent is installed in a reagent bag on a reagent hole of the microfluidic chip.
  • the urine flows into the reaction chamber through the corresponding reagent channel, the urine flows into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with the urine; the optical detection module detects the urine in the reaction chamber.
  • the mixed liquid after the reaction between the liquid and the detection reagent is subjected to optical detection to obtain detection data.
  • the application also provides a urine analysis device, comprising the above-mentioned microfluidic chip, a plurality of reagent capsules and a processor, wherein the plurality of reagent capsules are respectively installed on the reagent holes of the microfluidic chip, and the
  • the processor is connected to the optical detection module in the microfluidic chip; the processor is used to control the detection reagent in the reagent bag to flow into the reaction chamber through the corresponding reagent channel when urine flows in, and control the urine
  • the liquid flows into the reaction chamber through the urine channel, and the detection reagent flowing into the reaction chamber reacts with the urine;
  • the processor is further configured to use the optical detection module to detect the urine in the reaction chamber.
  • the mixed liquid reacted with the detection reagent is subjected to optical detection to obtain detection data; the processor is further configured to receive a plurality of detection data returned by the microfluidic chip to obtain urine analysis data.
  • the present application also provides a toilet, including the above-mentioned urine analysis device.
  • the microfluidic chip includes a chip main body, an optical detection module fixed on the chip main body, and a reaction cavity is formed in the chip main body. and a plurality of reagent channels connected to the reaction chamber, the plurality of reagent channels form a plurality of corresponding reagent holes on the chip body, the reaction chamber is also connected with a urine channel, and the urine channel forms a urine hole on the chip body , each reagent hole is used to install a reagent bag. After the urine and the detection reagent in the reagent bag flow into the reaction chamber for chemical reaction, the optical detection module can detect the urine in the reaction chamber based on the received detection instructions.
  • the mixed liquid after the reaction of the detection reagent is subjected to optical detection to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis for the user to view. Urine analysis data to understand your own physical health.
  • the microfluidic chip further includes a plurality of solenoid valves; the chip body is further formed with valve holes corresponding to the reagent holes one-to-one, and the solenoid valves are respectively installed on the chip At each valve hole on the main body; the solenoid valve is used to control the opening of the reagent hole corresponding to the valve hole when the detection instruction is received, so that the reagent bag installed on the opened reagent hole can be opened.
  • the detection reagent flows into the reaction chamber through the corresponding reagent channel.
  • the chip body includes an upper plate and a lower plate fixed to each other, and the reaction chamber, the urine channel and the reagent channel are formed between the upper plate and the lower plate, Both the reagent hole and the urine hole are formed on the upper surface of the upper plate.
  • the microfluidic chip further includes: a control circuit board; the control circuit board is fixed to the lower plate; each of the solenoid valves includes: an armature, an elastic device, a housing, an electromagnetic coil, and a magnetic core; a closed casing is arranged at each valve hole of the lower plate, the elastic device and the armature are both arranged in the casing, the armature is arranged on the elastic device, the The casing is fixed on the control circuit board, the casing is a hollow cylinder, the electromagnetic coil is fixed on the inner surface of the hollow cylinder, and the magnetic core is located inside the hollow cylinder and fixed on the inner surface of the hollow cylinder.
  • the control circuit board when the control circuit board is fixed to the lower board, the casing is located in the electromagnetic coil and is in contact with the magnetic core; when the electromagnetic valve is in an open state, the The armature moves toward the magnetic core, the elastic device is compressed by the armature, the solenoid valve is opened corresponding to the reagent hole, and the detection reagent in the reagent bag installed on the reagent hole flows into the reaction chamber through the corresponding reagent channel
  • the solenoid valve When the solenoid valve is in a closed state, the elastic device is in an initial state, and the armature closes the corresponding reagent hole of the solenoid valve.
  • the optical detection module includes: a light source and a chromatographic sensor; the light source is fixed on the upper plate at a position corresponding to the reaction chamber, and the chromatographic sensor is fixed on the lower plate and The position corresponding to the reaction cavity; when optically detecting the mixed liquid in the reaction cavity, the light source emits test light toward the reaction cavity, and the test light passes through the mixing in the reaction cavity The liquid is then irradiated to the chromatographic sensor.
  • the reaction chamber is formed with a plurality of light-transmitting upper detection points on the upper plate, and the reaction chamber is formed with a plurality of light-transmitting lower detection points on the lower plate , the upper detection point corresponds to the lower detection point one-to-one; the test light emitted by the light source towards the reaction chamber passes through the upper detection point, the mixed liquid in the reaction chamber and the lower detection point point irradiation to the chromatographic sensor.
  • the chip body is further formed with a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber, the cleaning inlet channel forms a cleaning inlet on the chip body, and the cleaning The outlet channel forms a cleaning outlet on the chip body; the cleaning inlet channel is used for cleaning the reaction chamber with cleaning liquid flowing in from the cleaning inlet; the cleaning outlet channel is used for the reaction chamber The cleaning liquid in the cavity flows out from the cleaning outlet.
  • an air channel connected to the reaction chamber is further formed in the chip body, and the air channel forms an air inlet on the chip body; the air channel is used for the reaction After the chamber is cleaned, supply air enters the reaction chamber from the air inlet to discharge the liquid in the reaction chamber.
  • a plurality of reagent wells share one of the reagent channels.
  • FIG. 1 is a schematic diagram of a urine analysis device and a toilet to which the microfluidic chip according to the first embodiment of the present application is applied;
  • FIG. 2 is a schematic structural diagram of a microfluidic chip according to the first embodiment of the present application.
  • FIG. 3 is a schematic structural diagram of the upper plate of the chip body of the microfluidic chip according to the first embodiment of the present application;
  • FIG. 4 is a schematic structural diagram of the lower plate of the chip body of the microfluidic chip according to the first embodiment of the present application;
  • 5 and 6 are schematic structural diagrams of a urine analysis device to which the microfluidic chip according to the second embodiment of the present application is applied;
  • FIG. 7 is a schematic structural diagram of a microfluidic chip according to a third embodiment of the present application.
  • FIG. 8 is a schematic structural diagram of an upper plate of a chip body of a microfluidic chip according to a fourth embodiment of the present application.
  • FIG. 11 is a schematic diagram of a toilet according to a seventh embodiment of the present application.
  • FIG. 12 is a schematic diagram of a urine analysis device in a toilet according to an eighth embodiment of the present application.
  • the first embodiment of the present application relates to a microfluidic chip, which is used for optical detection of urine.
  • the microfluidic chip can be arranged in a urine analysis device 10 , which is assembled with the urine analysis device 10 .
  • the urine analysis device 10 is fixed on the inner wall of the toilet 20 by means of bonding, and an opening 11 is formed on the shell of the urine analysis device 10, so that every time the user uses the toilet, the urine analysis device 10 can collect the user's urine through the opening 11 and input it into the microfluidic chip, and the microfluidic chip then performs optical detection on the urine.
  • the microfluidic chip includes a chip body and an optical detection module fixed on the chip body.
  • a reaction cavity and a plurality of detection reagent channels connected to the reaction cavity are formed in the chip main body, the plurality of reagent channels form a corresponding plurality of reagent holes on the chip main body, and the reaction cavity is also connected with a urine channel.
  • the channels form urine holes on the chip body, and each reagent hole is used to install a reagent capsule.
  • the reaction chamber is used for the urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent capsule.
  • the optical detection module is used for optical detection of the mixed liquid after the reaction between the urine and the detection reagent in the reaction chamber to obtain detection data.
  • the main body of the chip includes an upper plate 101 and a lower plate 102 that are fixed to each other.
  • a reaction chamber 103, a urine channel 104 and a reagent channel 105 are formed between the upper plate 101 and the lower plate 102.
  • the reagent holes 106 and the urine holes 107 are both formed in the upper plate 101 and the lower plate 102.
  • the reagent capsules 3 are installed in the respective reagent wells 106 .
  • a channel fence 1012 is set between the upper plate 101 and the lower plate 102, and the channel fence 1012 forms a plurality of channels for liquid supply in the chip body; the urine channel 104 and the reagent channel 105 share part of the channel in the chip body.
  • the optical detection module includes: a light source 21 and a chromatographic sensor 22 .
  • the light source 21 is fixed on the upper plate 101 at a position corresponding to the reaction chamber 103
  • the chromatographic sensor 22 is fixed on the lower plate 102 at a position corresponding to the reaction chamber 103 .
  • the light source 21 may be a laser, a light emitting diode, a halogen tungsten lamp, or the like.
  • the chromatographic sensor 22 includes a photodetector and a wavelength selector, the photodetector can convert the optical signal into an electrical signal, such as a photomultiplier tube, a photodiode, a CMOS sensor, etc.; the wavelength selector is used to select the set wavelength of the incident light , and the wavelength selector is, for example, a grating, a triangular prism, or an optical filter.
  • the light source 21 When optically detecting the mixed liquid in the reaction chamber 103 , the light source 21 emits test light toward the reaction chamber 103 , and the test light passes through the mixed liquid in the reaction chamber 103 and then irradiates the chromatographic sensor 22 .
  • the reaction chamber 103 has a plurality of light-transmitting upper detection points 1031 formed on the upper plate 101 , and the reaction chamber 103 has a plurality of light-transmitting lower detection points 1032 formed on the lower plate 102 .
  • 1031 corresponds to the lower detection point 1032 one-to-one.
  • the number of the above detection points 1031 and the number of the lower detection points 1032 is three as an example.
  • the test light emitted by the light source 21 toward the reaction chamber 103 is irradiated to the chromatographic sensor 22 through the upper detection point 1031 , the mixed liquid in the reaction chamber 103 , and the lower detection point 1032 .
  • the urine molecular device is provided with a processor, and the processor is connected to the optical detection module of the microfluidic chip; the processor can control the inflow of urine into the reaction chamber 103 of the microfluidic chip, and the processor also controls the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 of the microfluidic chip and into the reaction chamber 103 of the microfluidic chip
  • the urine chemically reacts with the detection reagent, and the processor sends a detection command to the optical detection module of the microfluidic chip. After the optical detection module receives the detection command, the light source 21 in the optical detection module sends out a pre-reaction towards the reaction chamber 103.
  • the test light enters the reaction cavity 103 through each upper detection point 1031, and is reflected in the mixed liquid in the reaction cavity 103, and the reflected light passes through the lower part.
  • the detection point 1032 illuminates the spectral sensor 22, and the wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, and the electrical signal is the detection data.
  • the senor 22 After the sensor 22 generates detection data, it will send the detection data to the processor; in one urine analysis, multiple detections of urine are required, and at this time, the plurality of reagent capsules installed on the microfluidic chip are equipped with Multiple detection reagents, multiple detection reagents react with urine in the reaction chamber, and the optical detection module will also perform multiple optical detections on urine to obtain multiple detection data, so that the processor can be based on these multiple detections.
  • the data generates urinalysis results for the user to review.
  • the microfluidic chip includes a chip main body, an optical detection module fixed on the chip main body, and a reaction cavity is formed in the chip main body.
  • Each reagent hole is used to install a reagent bag. After urine and the detection reagent in the reagent bag flow into the reaction chamber for chemical reaction, the optical detection module can detect the urine in the reaction chamber based on the received detection instruction.
  • the mixed liquid reacted with the detection reagent is subjected to optical detection to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis for the user. Check your urine analysis data to understand your physical health.
  • the second embodiment of the present application relates to a microfluidic chip.
  • the microfluidic chip in this embodiment further includes a plurality of solenoid valves, wherein The chip main body is also formed with valve holes corresponding to the reagent holes one-to-one, and each of the solenoid valves is respectively installed at each of the valve holes on the chip main body.
  • the solenoid valve is used to control the opening of the reagent hole corresponding to the valve hole when the detection instruction is received, so that the detection reagent in the reagent bag installed on the opened reagent hole flows into the reaction chamber through the corresponding reagent channel body.
  • the main body of the chip includes an upper plate 101 and a lower plate 102 that are fixed to each other.
  • a reaction chamber 103, a urine channel 104 and a reagent channel 105 are formed between the upper plate 101 and the lower plate 102.
  • the reagent holes 106 and the urine holes 107 are both formed in the upper plate 101 and the lower plate 102.
  • the reagent capsules 3 are installed in each reagent hole 106, the valve hole 121 forms the lower surface of the lower plate 102, and each solenoid valve 4 of the microfluidic chip is installed on each valve hole 121, and each solenoid valve 4 is installed on each valve hole 121.
  • the valve 4 is used to control the opening or closing of the corresponding reagent hole 106; in addition, the lower surface of the lower plate 102 also has a valve hole 121 corresponding to the urine hole 107, the valve hole 121 is also installed with the solenoid valve 4, the solenoid The valve 4 is used to control the opening or closing of the urine hole 107 .
  • a channel fence 1012 is set between the upper plate 101 and the lower plate 102, and the channel fence 1012 forms a plurality of channels for liquid supply in the chip body; the urine channel 104 and the reagent channel 105 share part of the channel in the chip body.
  • the optical detection module includes: a light source 21 and a chromatographic sensor 22 .
  • the light source 21 is fixed on the upper plate 101 at a position corresponding to the reaction chamber 103
  • the chromatographic sensor 22 is fixed on the lower plate 102 at a position corresponding to the reaction chamber 103 .
  • the light source 21 may be a laser, a light emitting diode, a halogen tungsten lamp, or the like.
  • the chromatographic sensor 22 includes a photodetector and a wavelength selector, the photodetector can convert the optical signal into an electrical signal, such as a photomultiplier tube, a photodiode, a CMOS sensor, etc.; the wavelength selector is used to select the set wavelength of the incident light , and the wavelength selector is, for example, a grating, a triangular prism, or an optical filter.
  • the light source 21 When optically detecting the mixed liquid in the reaction chamber 103 , the light source 21 emits test light toward the reaction chamber 103 , and the test light passes through the mixed liquid in the reaction chamber 103 and then irradiates the chromatographic sensor 22 .
  • the reaction chamber 103 has a plurality of light-transmitting upper detection points 1031 formed on the upper plate 101 , and the reaction chamber 103 has a plurality of light-transmitting lower detection points 1032 formed on the lower plate 102 .
  • 1031 corresponds to the lower detection point 1032 one-to-one.
  • the number of the above detection points 1031 and the number of the lower detection points 1032 is three as an example.
  • the test light emitted by the light source 21 toward the reaction chamber 103 is irradiated to the chromatographic sensor 22 through the upper detection point 1031 , the mixed liquid in the reaction chamber 103 , and the lower detection point 1032 .
  • the microfluidic chip further includes a control circuit board 5, and the control circuit board 5 is fixed to the lower board 102, and the fixing method can be fixed by screws.
  • Each solenoid valve 4 of the microfluidic chip is installed on the control circuit board 5, the processor 6 in the urine analysis device is installed on the main circuit board 6, and the control circuit board 5 is fixed and electrically connected to the main circuit board 7, Therefore, the processor 6 can control the opening or closing of each solenoid valve 4 .
  • the control circuit board 5 and the main circuit board 7 in this embodiment also include peripheral circuits, interfaces and other components, which will not be repeated here.
  • the urine analysis device further includes a casing, the casing includes an upper casing 81 and a lower casing 82 , and the opening 11 is formed on the upper casing 81 .
  • the processor 6 inputs the urine into the microcomputer multiple times based on the items to be detected.
  • the fluid control chip when the urine is detected for each item, the corresponding reagent hole 106 is opened by controlling the solenoid valve 4, so that the detection reagent in the reagent capsule 3 installed on the opened reagent hole 106 flows into the microfluidic chip.
  • the urine flowing into the reaction chamber 103 and the detection reagent can chemically react.
  • the processor 6 in the urine molecular device is connected to the optical detection module of the microfluidic chip; the processor 6 can control the urine
  • the liquid flows into the reaction chamber 103 of the microfluidic chip, and the processor 6 also opens the reagent hole 106 by controlling the solenoid valve 4 to control the detection reagent in the reagent capsule 3 to flow into the reaction chamber of the microfluidic chip.
  • the urine that flows into the reaction chamber 103 of the microfluidic chip chemically reacts with the detection reagent, and the processor 6 sends a detection instruction to the optical detection module of the microfluidic chip, and the optical detection module receives the detection instruction.
  • the light source 21 in the optical detection module emits test light (generally diffuse light) with a preset wavelength toward the reaction cavity 103 , and the test light enters the reaction cavity 103 through each upper detection point 1031 , and enters the reaction cavity 103 .
  • the mixed liquid in 103 generates reflection, and the reflected light passes through the lower detection point 1032 and irradiates the spectral sensor 22.
  • the wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then selects the set wavelength. The light is converted into an electrical signal, and the electrical signal is the detection data.
  • the spectral sensor 22 After the spectral sensor 22 generates the detection data, it will send the detection data to the processor 6; in a urine analysis, multiple detections of urine need to be carried out.
  • the multiple reagent capsules 3 installed on the microfluidic chip are loaded with multiple detection reagents, and the multiple detection reagents react with the urine in the reaction chamber 103 respectively, and the optical detection module will also conduct the urine detection respectively.
  • Multiple optical detections obtain multiple detection data, so that the processor 6 can generate a urine analysis result based on the multiple detection data for the user to view.
  • each of the solenoid valves 4 includes: an armature 41 , The elastic device 42 , the casing 43 , the electromagnetic coil 44 and the magnetic core 45 .
  • the elastic device 42 may be a device with elastic force such as a spring.
  • a closed casing 122 is disposed at each valve hole 121 of the lower plate 102 , the elastic device 42 and the armature 41 are both disposed in the casing 122 , and the armature 41 is disposed in the elastic device 42, the casing 43 is fixed on the control circuit board 5, the casing 43 is a hollow cylinder, the electromagnetic coil 44 is fixed on the inner surface of the hollow cylinder, and the magnetic core 45 is located at the inner surface of the hollow cylinder.
  • the inside of the hollow cylinder is fixed on the control circuit board 5; when the control circuit board 5 and the lower board 102 are fixed, the casing 122 is located in the electromagnetic coil 44 and is connected to the magnetic coil 44.
  • the cores 45 are in contact.
  • the solenoid valve 4 When the solenoid valve 4 is in the open state, the armature 41 moves toward the magnetic core 45 , the elastic device 42 is compressed by the armature 41 , the solenoid valve 4 is opened corresponding to the reagent hole 106 , and the reagent hole 106 The detection reagent in the reagent capsule 3 installed on the above flows into the reaction chamber 103 through the corresponding reagent channel.
  • the elastic device 42 When the solenoid valve 4 is in a closed state, the elastic device 42 is in an initial state, and the armature 41 closes the corresponding reagent hole 106 of the solenoid valve 4 .
  • the processor 6 When the processor 6 needs to control the detection reagent in a certain reagent capsule 3 to flow into the reaction chamber 103, it can energize the corresponding solenoid valve 4, the coil in the solenoid valve 4 generates a magnetic field, and the magnetic core 45 attracts the armature 41 to move toward it, The elastic device 42 is compressed from the initial state by the armature 41 , so that the reagent hole 106 closed by the armature 41 is opened, and at this time, the detection reagent in the reagent bag 3 installed in the reagent hole 106 flows into the reaction chamber 103 .
  • the fourth embodiment of the present application relates to a microfluidic chip. Compared with the first embodiment, the main difference between this embodiment is: please refer to FIG. 103 cleaning inlet channel and cleaning outlet channel, the cleaning inlet channel forms a cleaning inlet 108 on the upper surface of the upper plate 101 of the chip body, and the cleaning outlet channel forms a cleaning outlet 109 on the upper surface of the upper plate 101 of the chip body.
  • the cleaning inlet channel is used for cleaning the reaction chamber 103 with the cleaning liquid flowing in from the cleaning inlet 108 .
  • the cleaning outlet channel 109 is used for the cleaning liquid in the reaction chamber 103 to flow out from the cleaning outlet 109 .
  • the chip body is further formed with an air channel connected to the reaction chamber, and the air channel forms an air inlet 110 on the upper surface of the upper plate 101 of the chip body.
  • the air channel 112 is used to supply air into the reaction chamber 103 from the air inlet 110 after the reaction chamber 103 is cleaned, so as to discharge the liquid in the reaction chamber 103 .
  • a cleaning fluid connection channel and a waste fluid channel are also formed in the chip main body of the microfluidic chip.
  • the cleaning fluid connection channel forms a cleaning fluid interface 111 on the upper surface of the upper plate 101 of the chip main body, and the waste fluid channel is in A waste liquid outlet 112 is formed on the upper surface of the upper plate 101 of the chip body.
  • the chip body of the microfluidic chip is also formed with a ventilation channel, and the ventilation channel 118 forms a ventilation port 113 on the upper surface of the upper plate 101 of the chip body.
  • the cleaning inlet 108 and the cleaning outlet are connected to a cleaning pump (such as a diaphragm pump) in the urine analysis device, and the cleaning fluid interface 111 is connected to a cleaning fluid storage for storing cleaning fluid in the urine analysis device, and waste
  • the liquid outlet 112 is connected to one end of the peristaltic pump in the urine analysis device, and the other end of the peristaltic pump is connected to the waste liquid storage in the urine analyzer.
  • the reagent hole 106 , the urine hole 107 , the waste liquid outlet 112 , the cleaning liquid connection port 111 , the cleaning inlet 108 , the cleaning outlet 109 , the air inlet 110 and the ventilation port 113 on the microfluidic chip are all controlled by the corresponding valve 4 to open or open.
  • the microfluidic chip also includes a plurality of valves 4 , the lower plate 102 is provided with mounting holes corresponding to each opening or opening, and each valve 4 is installed on the lower plate 102 respectively. On the hole, the valve 4 is used to control the opening or closing of each opening or opening on the upper plate 101 .
  • each valve 4 can be arranged to be installed on a circuit board 5 with a control circuit, that is, the microfluidic chip also includes a circuit board 5, and the circuit board 5 is fixed to the lower board 102, and the fixing method can be fixed by screws;
  • the processor 6 in the urine analysis device is mounted on the circuit board 7 , and the circuit board 5 is fixed and electrically connected to the circuit board 7 , so that the processor 6 can control the opening or closing of each valve 4 .
  • the circuit board 5 and the circuit board 7 in this embodiment also include a plurality of components such as peripheral circuits and interfaces, which will not be repeated here.
  • the urine analysis device further includes a casing, the casing includes an upper casing 81 and a lower casing 82 , and the opening 11 is formed on the upper casing 81 .
  • the processor 6 inputs the urine into the microcomputer multiple times based on the items to be detected.
  • the fluid control chip when the urine is detected for each item, the corresponding detection reagents flow into the reaction chamber 103 of the microfluidic chip by controlling the valve to open, so as to flow into the urine in the reaction chamber 103. Can react chemically with detection reagents.
  • the processor 6 controls the valve 4 corresponding to the vent 113 to close, and controls the valve 4 corresponding to the urine hole 107 to open, and controls the peristaltic pump to pump from the urine storage.
  • the urine of the first preset ratio is sent to the reaction chamber 103, and then the valve 4 corresponding to the urine hole 107 is closed, and then the valve 4 corresponding to the reagent capsule 3 of the current test item is controlled to open, and the peristaltic pump is controlled from the reagent capsule 3.
  • the second preset ratio of the detection reagent is pumped into the reaction chamber 103, and then the valve 4 corresponding to the reagent capsule 3 is closed; at this time, the detection reagent and the urine react in the reaction chamber 103, and the processor 6 controls the microcomputer.
  • the optical detection module in the fluid control chip performs optical detection on the mixed liquid after the reaction between the urine and the detection reagent in the reaction chamber 103, and the optical detection module sends the detection data obtained by the optical detection to the processor 6, and the processor 6 determines the current
  • the processor 6 determines the current
  • the cleaning solution is pumped out of the memory to clean the reaction chamber 103 of the microfluidic chip, and then the cleaning solution connection port 111 and the valve 4 of the cleaning inlet 108 are closed; then the valve 4 of the cleaning outlet 109 is opened, and the cleaning pump is controlled to pump out of the reaction chamber Then close the valve 4 of the cleaning outlet 109, then open the corresponding valve 4 of the air inlet 27, pump air by the cleaning pump to discharge and dry the liquid in the reaction chamber 103, and then close the corresponding valve of the air inlet 27 4.
  • the processor 6 performs the detection of the next detection item, controls the valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out the urine of the first preset ratio from the urine storage to the reaction chamber 103, and then closes it again.
  • the valve 4 corresponding to the urine hole 107 is then controlled to open the valve 4 corresponding to the reagent bag 3 of the next test item, and the peristaltic pump is controlled to pump the second preset ratio of the detection reagent from the reagent bag 3 to the reaction chamber. 103, then close the valve 4 corresponding to the reagent capsule 3, and repeat the above process to complete the optical detection.
  • the detection items of the first test are all completed, and the processor 6 summarizes the test data of a plurality of test items in this urine test, and then obtains the urine analysis data of this urine test based on the plurality of test data.
  • valve 4 can be the solenoid valve described in the second embodiment and the third embodiment, then it can be obtained: the reagent hole 106 , the urine hole 107 and the waste liquid outlet 112 on the microfluidic chip , the cleaning liquid connection port 111, the cleaning inlet 108, the cleaning outlet 109, the air inlet 110 and the ventilation port 113 are controlled to open or close by the corresponding solenoid valve 4, and each solenoid valve 4 is installed on each valve hole 121 on the lower plate 102, respectively, The solenoid valve 4 is used to control the opening or closing of each opening or hole on the upper plate 101 .
  • the processor 6 controls the solenoid valve 4 corresponding to the air vent 113 to close, and controls the solenoid valve 4 corresponding to the urine hole 107 to open, and controls the peristaltic pump from the urine storage.
  • a second preset ratio of detection reagent is pumped out of the reagent bag 3 to the reaction chamber 103, and then the solenoid valve 4 corresponding to the reagent bag 3 is closed; at this time, the detection reagent and the urine react in the reaction chamber 103, and the processor 6.
  • the device 6 determines that the current detection item is completed, firstly controls the peristaltic pump to pump the reacted mixed liquid from the reaction chamber 103 to the waste liquid storage; then, controls to open the cleaning liquid connection port 111 and the solenoid valve 4 of the cleaning inlet 108, and controls
  • the cleaning pump pumps out cleaning fluid from the cleaning fluid storage to clean the reaction chamber 103 of the microfluidic chip, then closes the cleaning fluid connection port 111 and the solenoid valve 4 of the cleaning inlet 108; then opens the solenoid valve 4 of the cleaning outlet 109, Control the cleaning pump to pump out the cleaning liquid in the reaction chamber 103, then close the solenoid valve 4 of the cleaning outlet 109, and then open the air inlet 27 corresponding to the solenoid valve 4, and the cleaning pump pumps
  • the processor 6 performs the detection of the next detection item, controls the solenoid valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump out the urine of the first preset ratio from the urine storage to the reaction chamber 103, and then Close the solenoid valve 4 corresponding to the urine hole 107, then control the solenoid valve 4 corresponding to the reagent bag 3 of the next test item to open, and control the peristaltic pump to pump out the second preset ratio of the detection reagent from the reagent bag 3 to Reaction chamber 103, then close the solenoid valve 4 corresponding to the reagent capsule 3, repeat the above process to complete the optical detection, after each completion of the detection item, clean the reaction chamber 103, and then proceed to the next detection item after cleaning. Detection, until all the detection items are completed, the processor 6 summarizes the detection data of multiple detection items in this urine detection, and then obtains the urine analysis data of this urine detection
  • the types of detection reagents in the multiple reagent capsules correspond to multiple second preset ratios one-to-one, that is, based on different detection items, the amount of detection reagents required each time is different, so the processor 6.
  • the ratios of the reagents pumped from the different reagent capsules 3 to the reaction chamber 103 by the control peristaltic pump are different, so as to avoid the amount of the detection reagents affecting the detection data of the optical detection, and to a certain extent, ensure the urine analysis accuracy.
  • the fifth embodiment of the present application relates to a urine detection method, which is applied to the microfluidic chip described in any one of the first to fourth embodiments.
  • FIG. 9 is a specific flowchart of the urine detection method of the present embodiment.
  • Step 101 when the detection instruction is received, the detection reagent in the reagent capsule installed on the reagent hole of the microfluidic chip flows into the reaction chamber through the corresponding reagent channel, and the urine flows into the reaction chamber through the urine channel, and flows into the reaction chamber.
  • the detection reagent in the cavity reacts with the urine.
  • Step 102 the optical detection module performs optical detection on the mixed liquid after the reaction between the urine and the detection reagent in the reaction chamber to obtain detection data.
  • the urine molecular device when the user uses the toilet, urine flows in through the opening 11 of the urine analysis device, the urine molecular device is provided with a processor, and the processor is connected to the optical detection module of the microfluidic chip; the processor can Control the flow of urine into the reaction chamber 103 of the microfluidic chip, and at the same time, the processor will also control the detection reagent in the reagent capsule 3 to flow into the reaction chamber 103 of the microfluidic chip, and flow into the reaction chamber 103 of the microfluidic chip.
  • the urine in the cavity 103 chemically reacts with the detection reagent, and the processor sends a detection command to the optical detection module of the microfluidic chip.
  • the light source 21 in the optical detection module faces the reaction chamber.
  • the body 103 emits test light with a preset wavelength (generally diffuse light), and the test light is injected into the reaction cavity 103 through each upper detection point 1031, and is reflected in the mixed liquid in the reaction cavity 103.
  • the light irradiates the spectral sensor 22 through the lower detection point 1032, and the wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then converts the light of the set wavelength into an electrical signal, and the electrical signal is Detection data, after the spectral sensor 22 generates detection data, it will send the detection data to the processor; in a urine analysis, multiple detections of urine need to be performed, and at this time, multiple reagents installed on the microfluidic chip are A variety of detection reagents are installed in the capsule, and a variety of detection reagents react with urine in the reaction chamber respectively. The optical detection module will also perform multiple optical detections on the urine to obtain multiple detection data, so that the processor can These multiple test data generate urinalysis results for the user to review.
  • the microfluidic chip includes a chip main body, an optical detection module fixed on the chip main body, and a reaction cavity is formed in the chip main body.
  • Each reagent hole is used to install a reagent bag. After urine and the detection reagent in the reagent bag flow into the reaction chamber for chemical reaction, the optical detection module can detect the urine in the reaction chamber based on the received detection instruction.
  • the mixed liquid reacted with the detection reagent is subjected to optical detection to obtain detection data, that is, the microfluidic chip can perform at least one optical detection on the user's urine, so that the user's urine can be analyzed on a daily basis for the user. Check your urine analysis data to understand your physical health.
  • the sixth embodiment of the present application relates to a method for detecting urine. Compared with the fifth embodiment, this embodiment is mainly different in that: this embodiment is applied to any one of the second or third embodiment.
  • the microfluidic chip that is, the microfluidic chip further includes: a plurality of solenoid valves, see FIG. 2 to FIG. 7 for details.
  • FIG. 10 is a specific flowchart of the urine detection method of the present embodiment.
  • Step 201 when receiving the detection instruction, control the opening of the corresponding reagent hole through the solenoid valve in the microfluidic chip, and the detection reagent installed in the reagent capsule on the opened reagent hole flows into the reaction through the corresponding reagent channel.
  • a cavity urine flows into the reaction cavity through the urine channel, and the reagent flowing into the reaction cavity reacts with the urine.
  • Step 202 the optical detection module performs optical detection on the mixed liquid in the reaction chamber after the reaction between the urine and the detection reagent, to obtain detection data.
  • the light source in the optical detection module is used to emit test light toward the reaction cavity, and the test light passes through the mixed liquid in the reaction cavity and then irradiates the chromatographic sensor to obtain detection data.
  • the light source 21 in the optical detection module emits test light (generally diffused light) with a preset wavelength toward the reaction cavity 103, and the test light enters the reaction cavity 103 through each upper detection point 1031, and is emitted at the reaction cavity 103.
  • the mixed liquid in the reaction chamber 103 generates reflection, and the reflected light irradiates the spectral sensor 22 through the lower detection point 1032.
  • the wavelength selection in the spectral sensor 22 first selects the light of the set wavelength from the incident light, and then selects the light of the set wavelength from the incident light.
  • the light of the set wavelength is converted into an electrical signal, and the electrical signal is the detection data.
  • the detection data will be sent to the processor 6; in a urine analysis, the urine needs to be analyzed.
  • multiple reagent capsules 3 installed on the microfluidic chip contain multiple detection reagents, and multiple detection reagents react with urine in the reaction chamber 103 respectively, and the optical detection module will also detect urine.
  • the liquid is respectively subjected to multiple optical detections to obtain multiple detection data, so that the processor 6 can generate a urine analysis result based on the multiple detection data for the user to view.
  • the seventh embodiment of the present application relates to a urine analysis device for detecting the urine of a user.
  • the urine analysis device 10 is assembled in the toilet 20.
  • the urine analysis device 10 is glued It is fixed on the inner wall of the toilet bowl 20 in a way, so that the user's urine can be collected for detection every time the user uses the toilet bowl.
  • the urine analysis device includes the microfluidic chip of any one of the first to fourth embodiments, a plurality of reagent capsules 3 and a processor 6 .
  • the urine analysis device further includes a casing, the casing includes an upper casing 81 and a lower casing 82 , and the opening 11 is formed on the upper casing 81 .
  • the processor 6 is used to control the detection reagent in the reagent bag 3 to flow into the reaction chamber 103 through the corresponding reagent channel when urine flows in, and to control the urine to flow into the reaction chamber 103 through the urine channel and into the reaction chamber 103
  • the detection reagents in the urine react with the urine.
  • the processor 6 is further configured to perform optical detection on the mixed liquid after the reaction between the urine and the detection reagent in the reaction chamber 103 by using the optical detection module to obtain detection data.
  • the processor 6 is further configured to receive multiple detection data returned by the microfluidic chip to obtain urine analysis data.
  • the urine analysis device is also provided with a wireless communication module (not shown in the figure, the wireless communication module can be installed on the circuit board 7 ), such as WIFI, 4G, 5G, etc., so that the processor 6 can pass Wirelessly connect to the cloud server, and send the urine analysis data obtained by each urine test to the cloud server, and the cloud server will monitor the user's urine analysis data for a long period of time, such as 7 days, 15 days, 30 days, etc.
  • the user can also connect electronic devices such as mobile phones and computers with the urine analysis device, so that the processor 6 can also send the urine analysis data to the user's electronic device, so that the user can view his own urine analysis data in real time. , check your own physical condition through urinalysis data.
  • different types of detection reagents can be respectively installed in the multiple reagent capsules, and the types of detection reagents can be set according to the detection items of urine.
  • Creatinine analysis buffer sulfosalicylic acid solution was used for the detection of urine protein
  • bromothymol blue solution was used for the detection of uric acid and alkalinity
  • ferric chloride was used for the detection of urine ketone ;
  • the detection reagents used in the detection of vitamin C are acid buffer, phenanthroline chromogenic solution and VC analysis buffer
  • the detection reagent used in the detection of urine nitrite is Gries' solution; it should be noted that the above only lists Some test items and required test reagents can also be increased or decreased as needed, such as increased urine albumin, urine hemoglobin detection, etc.
  • the urine analysis device in this embodiment may also include a battery holder (not shown in the figure), the battery holder is connected to the circuit board 202, and when a battery is installed in the battery holder, the battery can be used for urine
  • the processor 6 in the liquid analysis device and the optical detection module 204, the valve 201 and the like in the microfluidic chip are powered.
  • the urine analysis device in this embodiment may further include a residual sensor for detecting the residual amount of the detection reagent in each reagent capsule, and each residual sensor is respectively connected to the processor 6, so that the processor 6 can detect the residual amount of the reagent in any reagent capsule.
  • a reminder is issued in time, and the reminder method is, for example, sending a reminder message to the electronic device of the connected user through a cloud server or directly.
  • the urine analysis device further includes: a power receiving module 901 and a power supply 902 , and the power receiving module 901 is respectively connected to the processor 6 and the microfluidic chip.
  • the urine analysis device 10 is assembled on the inner wall of the toilet 20, and the power supply receiving module 901 is fixed in a preset area inside the casing, that is, the power supply receiving module 901 is assembled in a preset area on the lower casing 31 of the casing.
  • the area is located on the lower casing 82 of the casing near the inner wall of the toilet 20 ; Wherein, the power supply 902 can be fixed on the toilet 20 by means of adhesion.
  • the power supply 902 is used to provide power for the power receiving module 901 .
  • the power supply receiving module 901 is used to supply power to the processor 6 and the microfluidic chip respectively by using the received electrical energy.
  • the power supply receiving module 901 includes a charging chip 9011 and a wireless receiving coil 9012 .
  • the charging chip 9011 is arranged on the circuit board 7 , and the wireless receiving coil 9012 is fixed on the casing 82
  • the wireless receiving coil 9012 is connected to the circuit board 7 of the urine analysis device 10, and the wireless receiving coil 9012 is connected to the charging chip 9011 through the wiring on the circuit board 7, and the power supply 102
  • a wireless transmitting coil and a battery pack (not shown in the figure) are provided, the battery pack is connected to the wireless transmitting coil, and the electric energy of the battery pack is converted into a magnetic field by the wireless transmitting coil, and the wireless receiving coil 9012 is induced by the existence of the alternating magnetic field.
  • the alternating current is output, and then the wireless charging chip 9011 on the circuit board 7 converts the alternating current into direct current to supply power to the processor 6 and the microfluidic chip respectively.
  • FIG. 11 only schematically depicts the positions of the charging chip 9011 and the wireless receiving coil 9012, but it is not limited to this, and a power supply circuit board for fixing the charging chip 9011 can also be provided, and the wireless receiving coil 9012 is fixed On the housing 82 and inside the urine analysis device, the wire receiving coil 1012 is connected to the charging chip 9011 through the power supply circuit board.
  • the power supply 902 uses the power supply receiving module 901 to wirelessly supply power to the urine analysis device 10, so that the user can maintain the power supply of the urine analysis device 10 by charging the power supply 902, which is more convenient and convenient for the user. to operate.
  • the battery pack in the power supply 902 can be a rechargeable battery pack.
  • the power supply 902 is provided with a charging interface.
  • the power supply 902 can be connected to an external power source through a charging cable, and the rechargeable battery pack is charged by the external power source.
  • the types of detection reagents in the multiple reagent capsules correspond to multiple second preset ratios one-to-one, that is, based on different detection items, the amount of detection reagents required each time is different, so the processor 6.
  • the ratio of the reagents pumped from different reagent capsules to the reaction chamber by the peristaltic pump is different, so as to avoid the amount of the detection reagents affecting the detection data of the optical detection, and to a certain extent ensure the accuracy of the urine analysis sex.
  • the urine analysis device is further provided with a temperature sensor (not shown in the figure), the temperature sensor is arranged at the opening 11 or at a position close to the opening 11 in the housing, and is connected to the circuit board 7, so that The processor 6 is electrically connected to the temperature sensor through the circuit board 7.
  • the temperature detected by the temperature sensor is the indoor temperature, and the indoor temperature value is sent to the processor 6; when a user uses the toilet 20,
  • the temperature sensor detects the urine temperature value of the user, and sends the detected urine temperature value to the processor 6.
  • the urine temperature value is greater than the indoor temperature
  • the processor 6 determines that the detected temperature value increases, and the difference between the urine temperature value minus the indoor temperature value is greater than or equal to the preset first temperature threshold, and determines that it is detected that the urine flows into the urine analysis device, and the processor 6 controls
  • the urine analysis device enters the detection state and wakes up the microfluidic chip for urine detection.
  • the first temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, and the like.
  • the processor 6 is further configured to receive multiple detection data returned by the microfluidic chip and obtain urine analysis data, if the temperature value sent by the temperature sensor decreases and the temperature decrease value is greater than or equal to a preset value When the second temperature threshold is reached, the urine analysis device is controlled to enter a standby state.
  • the temperature value of the water detected by the temperature sensor is sent to the processor 6, and the temperature value of the water sent by the temperature sensor received by the processor 6 is If it is less than the urine temperature value, it is determined that the temperature has decreased and the temperature decrease value is greater than or equal to the preset second temperature threshold, indicating that the user has finished using the toilet, and the urine analysis device is controlled to enter the standby state again, thereby reducing the urine analysis device. power consumption.
  • the second temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, and the like.
  • the processor 6 is further configured to adjust the first temperature threshold and the second temperature threshold according to the currently detected temperature value when the temperature value sent by the temperature sensor is received and remains unchanged for a preset time.
  • the temperature detected by the temperature sensor at this time is the indoor temperature at this time. Since the indoor temperature will change with the seasons, and the temperature of human urine is basically constant, so The first temperature threshold and the second temperature threshold can be adjusted in real time according to the indoor temperature value. For example, in summer, the indoor temperature is high, and the temperature difference between the indoor temperature and the urine temperature decreases, and the first temperature threshold can be appropriately reduced. and the second temperature threshold; in winter, the indoor temperature is low, and the temperature difference between the indoor temperature and the urine temperature increases, and the first temperature threshold and the second temperature threshold can be appropriately increased.
  • the urine analysis device in this embodiment can analyze the correlation data between the user's metabolism and the user's daily behavior status based on the user's urine analysis data collected continuously and for a long time. For example, the user's eating habits (including meals, nutrition, vitamins, tobacco and alcohol, etc.), disease status, routine of work and rest, exercise habits, sleep status, or taking drugs and other behavioral states will be presented in the user's urine. After some behavioral states of the user change, it will have a corresponding impact on the user's urine.
  • the urine analysis device can also check the changes in urine, and then the urine analysis device can be based on long-term, continuous urine analysis. The data is analyzed to obtain the correlation between the user's metabolism and the user's behavioral state.
  • first to sixth embodiments correspond to this embodiment, this embodiment can be implemented in cooperation with the first to sixth embodiments.
  • the relevant technical details mentioned in the first to sixth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to sixth embodiments can also be realized in this embodiment. In order to reduce repetition , which will not be repeated here.
  • the related technical details mentioned in this embodiment can also be applied to the first to sixth embodiments.
  • the eighth embodiment of the present application relates to a toilet, including the urine analysis device in the seventh embodiment.
  • the urine analysis device 10 is assembled in the toilet 20, for example, the urine analysis device 10 is fixed on the inner wall of the toilet 20 by means of bonding, so that the user's urine can be collected every time the user uses the toilet test.
  • first to seventh embodiments correspond to this embodiment, this embodiment can be implemented in cooperation with the first to seventh embodiments.
  • the relevant technical details mentioned in the first to seventh embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to seventh embodiments can also be achieved in this embodiment. In order to reduce repetition , which will not be repeated here.

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Abstract

Les modes de réalisation de la présente demande se rapportent au domaine technique de la détection. La présente demande concerne une puce microfluidique, un procédé et un dispositif d'analyse d'urine et des toilettes. La puce microfluidique comprend : un corps principal de puce et un module de détection optique fixé sur le corps principal de puce, une cavité de réaction et une pluralité de canaux de réactif reliés à la cavité de réaction étant formés dans le corps principal de puce, la pluralité de canaux de réactif forment une pluralité de trous de réactif correspondants sur le corps principal de puce, la cavité de réaction est en outre reliée à un canal d'urine, le canal d'urine forme un trou d'urine sur le corps principal de puce et chaque trou de réactif est utilisé pour monter une capsule de réactif ; la cavité de réaction est utilisée pour permettre à l'urine s'écoulant dans la puce microfluidique de réagir avec un réactif de détection dans la capsule de réactif ; et le module de détection optique est utilisé pour effectuer, après qu'une instruction de détection est reçue, une détection optique sur un liquide mélangé dans la cavité de réaction qui est obtenu après que l'urine a réagi avec le réactif de détection, de façon à obtenir des données de détection. La présente demande produit une puce microfluidique ayant une fonction de détection optique et la puce microfluidique peut effectuer au moins un type de détection optique sur l'urine d'un utilisateur.
PCT/CN2021/142105 2021-02-22 2021-12-28 Puce microfluidique, procédé et dispositif d'analyse d'urine et toilettes WO2022174676A1 (fr)

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CN202110197150.6A CN112834497A (zh) 2021-02-22 2021-02-22 微流控芯片、尿液分析方法及装置、马桶
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