WO2022173334A2 - Procédés, compositions et composés pour le traitement de maladies et d'états liés à l'âge - Google Patents
Procédés, compositions et composés pour le traitement de maladies et d'états liés à l'âge Download PDFInfo
- Publication number
- WO2022173334A2 WO2022173334A2 PCT/RU2022/050045 RU2022050045W WO2022173334A2 WO 2022173334 A2 WO2022173334 A2 WO 2022173334A2 RU 2022050045 W RU2022050045 W RU 2022050045W WO 2022173334 A2 WO2022173334 A2 WO 2022173334A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- days
- disease
- compound selected
- treatment
- subject
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 449
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 269
- 201000010099 disease Diseases 0.000 title claims description 160
- 238000000034 method Methods 0.000 title claims description 136
- 239000000203 mixture Substances 0.000 title claims description 34
- 238000011282 treatment Methods 0.000 claims description 322
- 210000004027 cell Anatomy 0.000 claims description 133
- 208000035475 disorder Diseases 0.000 claims description 108
- 206010028980 Neoplasm Diseases 0.000 claims description 95
- 230000009758 senescence Effects 0.000 claims description 87
- 201000011510 cancer Diseases 0.000 claims description 67
- 230000007423 decrease Effects 0.000 claims description 67
- 230000032683 aging Effects 0.000 claims description 58
- 208000024891 symptom Diseases 0.000 claims description 54
- 238000001959 radiotherapy Methods 0.000 claims description 51
- 230000000694 effects Effects 0.000 claims description 49
- 238000002560 therapeutic procedure Methods 0.000 claims description 42
- 206010012601 diabetes mellitus Diseases 0.000 claims description 35
- 208000010877 cognitive disease Diseases 0.000 claims description 32
- 230000001603 reducing effect Effects 0.000 claims description 32
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 31
- 230000003712 anti-aging effect Effects 0.000 claims description 31
- 208000008589 Obesity Diseases 0.000 claims description 29
- 230000001965 increasing effect Effects 0.000 claims description 29
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 28
- 235000020824 obesity Nutrition 0.000 claims description 28
- 208000036119 Frailty Diseases 0.000 claims description 27
- 206010003549 asthenia Diseases 0.000 claims description 27
- 101000689696 Homo sapiens Alpha-1D adrenergic receptor Proteins 0.000 claims description 26
- -1 KIT Proteins 0.000 claims description 26
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 25
- 208000024827 Alzheimer disease Diseases 0.000 claims description 24
- 102100021633 Cathepsin B Human genes 0.000 claims description 24
- 101000898449 Homo sapiens Cathepsin B Proteins 0.000 claims description 24
- 208000018737 Parkinson disease Diseases 0.000 claims description 24
- 208000002780 macular degeneration Diseases 0.000 claims description 23
- 208000030159 metabolic disease Diseases 0.000 claims description 23
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims description 22
- 102100039126 5-hydroxytryptamine receptor 7 Human genes 0.000 claims description 21
- 102000017908 ADRA1B Human genes 0.000 claims description 21
- 108091005625 BRD4 Proteins 0.000 claims description 21
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 claims description 21
- 108010044266 Dopamine Plasma Membrane Transport Proteins Proteins 0.000 claims description 21
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims description 21
- 102100039996 Histone deacetylase 1 Human genes 0.000 claims description 21
- 102100039999 Histone deacetylase 2 Human genes 0.000 claims description 21
- 102100021455 Histone deacetylase 3 Human genes 0.000 claims description 21
- 101000744211 Homo sapiens 5-hydroxytryptamine receptor 7 Proteins 0.000 claims description 21
- 101000689698 Homo sapiens Alpha-1B adrenergic receptor Proteins 0.000 claims description 21
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims description 21
- 101001035024 Homo sapiens Histone deacetylase 1 Proteins 0.000 claims description 21
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 claims description 21
- 101000899282 Homo sapiens Histone deacetylase 3 Proteins 0.000 claims description 21
- 108010049586 Norepinephrine Plasma Membrane Transport Proteins Proteins 0.000 claims description 21
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 claims description 21
- 201000008482 osteoarthritis Diseases 0.000 claims description 21
- 208000001132 Osteoporosis Diseases 0.000 claims description 20
- 230000003247 decreasing effect Effects 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 19
- 208000002177 Cataract Diseases 0.000 claims description 18
- 206010020772 Hypertension Diseases 0.000 claims description 18
- 208000006011 Stroke Diseases 0.000 claims description 18
- 201000001320 Atherosclerosis Diseases 0.000 claims description 17
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims description 16
- 102100021257 Beta-secretase 1 Human genes 0.000 claims description 16
- 102100021277 Beta-secretase 2 Human genes 0.000 claims description 16
- 102100025172 Calpain-1 catalytic subunit Human genes 0.000 claims description 16
- 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 claims description 16
- 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 claims description 16
- 101150112743 HSPA5 gene Proteins 0.000 claims description 16
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims description 16
- 101000894883 Homo sapiens Beta-secretase 2 Proteins 0.000 claims description 16
- 101000934069 Homo sapiens Calpain-1 catalytic subunit Proteins 0.000 claims description 16
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims description 16
- 101000891092 Homo sapiens TAR DNA-binding protein 43 Proteins 0.000 claims description 16
- 101000652472 Homo sapiens Tubulin beta-6 chain Proteins 0.000 claims description 16
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims description 16
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims description 16
- 102100040347 TAR DNA-binding protein 43 Human genes 0.000 claims description 16
- 102100030303 Tubulin beta-6 chain Human genes 0.000 claims description 16
- 102100038720 Histone deacetylase 9 Human genes 0.000 claims description 15
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 15
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 15
- 208000010125 myocardial infarction Diseases 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 14
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 claims description 13
- 102100024956 5-hydroxytryptamine receptor 2B Human genes 0.000 claims description 13
- 102100024959 5-hydroxytryptamine receptor 2C Human genes 0.000 claims description 13
- 102100040368 5-hydroxytryptamine receptor 6 Human genes 0.000 claims description 13
- 102000017907 ADRA1D Human genes 0.000 claims description 13
- 102100024401 Alpha-1D adrenergic receptor Human genes 0.000 claims description 13
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 claims description 13
- 102100033642 Bromodomain-containing protein 3 Human genes 0.000 claims description 13
- 102100029813 D(1B) dopamine receptor Human genes 0.000 claims description 13
- 102100020756 D(2) dopamine receptor Human genes 0.000 claims description 13
- 102100029808 D(3) dopamine receptor Human genes 0.000 claims description 13
- 102100021604 Ephrin type-A receptor 6 Human genes 0.000 claims description 13
- 102100021601 Ephrin type-A receptor 8 Human genes 0.000 claims description 13
- 108091005772 HDAC11 Proteins 0.000 claims description 13
- 102100032509 Histamine H1 receptor Human genes 0.000 claims description 13
- 102100039385 Histone deacetylase 11 Human genes 0.000 claims description 13
- 102100021454 Histone deacetylase 4 Human genes 0.000 claims description 13
- 102100021453 Histone deacetylase 5 Human genes 0.000 claims description 13
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims description 13
- 102100038715 Histone deacetylase 8 Human genes 0.000 claims description 13
- 101000783617 Homo sapiens 5-hydroxytryptamine receptor 2A Proteins 0.000 claims description 13
- 101000761319 Homo sapiens 5-hydroxytryptamine receptor 2B Proteins 0.000 claims description 13
- 101000761348 Homo sapiens 5-hydroxytryptamine receptor 2C Proteins 0.000 claims description 13
- 101000964051 Homo sapiens 5-hydroxytryptamine receptor 6 Proteins 0.000 claims description 13
- 101000864666 Homo sapiens ATP-dependent RNA helicase DHX8 Proteins 0.000 claims description 13
- 101000689685 Homo sapiens Alpha-1A adrenergic receptor Proteins 0.000 claims description 13
- 101000871850 Homo sapiens Bromodomain-containing protein 2 Proteins 0.000 claims description 13
- 101000871851 Homo sapiens Bromodomain-containing protein 3 Proteins 0.000 claims description 13
- 101000865210 Homo sapiens D(1B) dopamine receptor Proteins 0.000 claims description 13
- 101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 claims description 13
- 101000865224 Homo sapiens D(3) dopamine receptor Proteins 0.000 claims description 13
- 101000898696 Homo sapiens Ephrin type-A receptor 6 Proteins 0.000 claims description 13
- 101000898676 Homo sapiens Ephrin type-A receptor 8 Proteins 0.000 claims description 13
- 101001016841 Homo sapiens Histamine H1 receptor Proteins 0.000 claims description 13
- 101000899259 Homo sapiens Histone deacetylase 4 Proteins 0.000 claims description 13
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 claims description 13
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims description 13
- 101001032113 Homo sapiens Histone deacetylase 7 Proteins 0.000 claims description 13
- 101001032118 Homo sapiens Histone deacetylase 8 Proteins 0.000 claims description 13
- 101001032092 Homo sapiens Histone deacetylase 9 Proteins 0.000 claims description 13
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 13
- 101001059982 Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Proteins 0.000 claims description 13
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims description 13
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims description 13
- 101000595746 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Proteins 0.000 claims description 13
- 101001035694 Homo sapiens Polyamine deacetylase HDAC10 Proteins 0.000 claims description 13
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 claims description 13
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 13
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims description 13
- 101001047681 Homo sapiens Tyrosine-protein kinase Lck Proteins 0.000 claims description 13
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims description 13
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 13
- 102100028195 Mitogen-activated protein kinase kinase kinase kinase 5 Human genes 0.000 claims description 13
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical compound C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims description 13
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims description 13
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims description 13
- 102100036056 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Human genes 0.000 claims description 13
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims description 13
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims description 13
- 102100039388 Polyamine deacetylase HDAC10 Human genes 0.000 claims description 13
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 claims description 13
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 13
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims description 13
- 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 claims description 13
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims description 13
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims description 13
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 13
- 208000029078 coronary artery disease Diseases 0.000 claims description 13
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 13
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 13
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 13
- 101000841393 Candida albicans Probable NADPH dehydrogenase Proteins 0.000 claims description 12
- 206010012289 Dementia Diseases 0.000 claims description 12
- 101000866618 Homo sapiens 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Proteins 0.000 claims description 12
- 101000765010 Homo sapiens Beta-galactosidase Proteins 0.000 claims description 12
- 101000616556 Homo sapiens SH3 domain-containing protein 19 Proteins 0.000 claims description 12
- 230000007850 degeneration Effects 0.000 claims description 12
- 101000617738 Homo sapiens Survival motor neuron protein Proteins 0.000 claims description 11
- 102100021947 Survival motor neuron protein Human genes 0.000 claims description 11
- 238000011161 development Methods 0.000 claims description 11
- 230000018109 developmental process Effects 0.000 claims description 11
- 206010019280 Heart failures Diseases 0.000 claims description 10
- 101000617546 Homo sapiens Presenilin-2 Proteins 0.000 claims description 10
- 102100022036 Presenilin-2 Human genes 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 10
- 230000000750 progressive effect Effects 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 9
- 208000001076 sarcopenia Diseases 0.000 claims description 9
- 230000035882 stress Effects 0.000 claims description 9
- 102100022528 5'-AMP-activated protein kinase catalytic subunit alpha-1 Human genes 0.000 claims description 8
- 102100024628 5'-AMP-activated protein kinase subunit gamma-3 Human genes 0.000 claims description 8
- 108091007505 ADAM17 Proteins 0.000 claims description 8
- 102000017906 ADRA2A Human genes 0.000 claims description 8
- 102000017905 ADRA2B Human genes 0.000 claims description 8
- 102000017904 ADRA2C Human genes 0.000 claims description 8
- 102100027447 ATP-dependent DNA helicase Q1 Human genes 0.000 claims description 8
- 102000007370 Ataxin2 Human genes 0.000 claims description 8
- 108010032951 Ataxin2 Proteins 0.000 claims description 8
- 102100028282 Bile salt export pump Human genes 0.000 claims description 8
- 102100035631 Bloom syndrome protein Human genes 0.000 claims description 8
- 108091009167 Bloom syndrome protein Proteins 0.000 claims description 8
- 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 claims description 8
- 102100021975 CREB-binding protein Human genes 0.000 claims description 8
- 102100033040 Carbonic anhydrase 12 Human genes 0.000 claims description 8
- 102100036372 Carbonic anhydrase 5A, mitochondrial Human genes 0.000 claims description 8
- 102100036368 Carbonic anhydrase 7 Human genes 0.000 claims description 8
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 8
- 102100024940 Cathepsin K Human genes 0.000 claims description 8
- 102100035654 Cathepsin S Human genes 0.000 claims description 8
- 102100032919 Chromobox protein homolog 1 Human genes 0.000 claims description 8
- 102100027995 Collagenase 3 Human genes 0.000 claims description 8
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 claims description 8
- 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 claims description 8
- 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 claims description 8
- 102100029815 D(4) dopamine receptor Human genes 0.000 claims description 8
- 102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 claims description 8
- 101100457345 Danio rerio mapk14a gene Proteins 0.000 claims description 8
- 101100457347 Danio rerio mapk14b gene Proteins 0.000 claims description 8
- 102100020751 Dipeptidyl peptidase 2 Human genes 0.000 claims description 8
- 101710087012 Dipeptidyl-peptidase 7 Proteins 0.000 claims description 8
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 claims description 8
- 102100040844 Dual specificity protein kinase CLK2 Human genes 0.000 claims description 8
- 102100040858 Dual specificity protein kinase CLK4 Human genes 0.000 claims description 8
- 102100030862 Eyes absent homolog 2 Human genes 0.000 claims description 8
- 102100039111 FAD-linked sulfhydryl oxidase ALR Human genes 0.000 claims description 8
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 claims description 8
- 108090000652 Flap endonucleases Proteins 0.000 claims description 8
- 102000004150 Flap endonucleases Human genes 0.000 claims description 8
- 102100033264 Geranylgeranyl transferase type-1 subunit beta Human genes 0.000 claims description 8
- 102100032510 Heat shock protein HSP 90-beta Human genes 0.000 claims description 8
- 101000677993 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-1 Proteins 0.000 claims description 8
- 101000760977 Homo sapiens 5'-AMP-activated protein kinase subunit gamma-3 Proteins 0.000 claims description 8
- 101000580659 Homo sapiens ATP-dependent DNA helicase Q1 Proteins 0.000 claims description 8
- 101000756842 Homo sapiens Alpha-2A adrenergic receptor Proteins 0.000 claims description 8
- 101000929512 Homo sapiens Alpha-2B adrenergic receptor Proteins 0.000 claims description 8
- 101000720032 Homo sapiens Alpha-2C adrenergic receptor Proteins 0.000 claims description 8
- 101000896987 Homo sapiens CREB-binding protein Proteins 0.000 claims description 8
- 101000867855 Homo sapiens Carbonic anhydrase 12 Proteins 0.000 claims description 8
- 101000714503 Homo sapiens Carbonic anhydrase 5A, mitochondrial Proteins 0.000 claims description 8
- 101000714519 Homo sapiens Carbonic anhydrase 7 Proteins 0.000 claims description 8
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 claims description 8
- 101000761509 Homo sapiens Cathepsin K Proteins 0.000 claims description 8
- 101000947086 Homo sapiens Cathepsin S Proteins 0.000 claims description 8
- 101000797584 Homo sapiens Chromobox protein homolog 1 Proteins 0.000 claims description 8
- 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 claims description 8
- 101000911952 Homo sapiens Cyclin-dependent kinase 7 Proteins 0.000 claims description 8
- 101000865206 Homo sapiens D(4) dopamine receptor Proteins 0.000 claims description 8
- 101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 claims description 8
- 101000749291 Homo sapiens Dual specificity protein kinase CLK2 Proteins 0.000 claims description 8
- 101000749298 Homo sapiens Dual specificity protein kinase CLK4 Proteins 0.000 claims description 8
- 101000938438 Homo sapiens Eyes absent homolog 2 Proteins 0.000 claims description 8
- 101000959079 Homo sapiens FAD-linked sulfhydryl oxidase ALR Proteins 0.000 claims description 8
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 claims description 8
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 claims description 8
- 101001071129 Homo sapiens Geranylgeranyl transferase type-1 subunit beta Proteins 0.000 claims description 8
- 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 claims description 8
- 101100508538 Homo sapiens IKBKE gene Proteins 0.000 claims description 8
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 claims description 8
- 101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 claims description 8
- 101000997662 Homo sapiens Lysosomal acid glucosylceramidase Proteins 0.000 claims description 8
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims description 8
- 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 claims description 8
- 101000628954 Homo sapiens Mitogen-activated protein kinase 12 Proteins 0.000 claims description 8
- 101001124388 Homo sapiens NPC intracellular cholesterol transporter 1 Proteins 0.000 claims description 8
- 101000990908 Homo sapiens Neutrophil collagenase Proteins 0.000 claims description 8
- 101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 claims description 8
- 101000741790 Homo sapiens Peroxisome proliferator-activated receptor gamma Proteins 0.000 claims description 8
- 101000595741 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Proteins 0.000 claims description 8
- 101000595751 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Proteins 0.000 claims description 8
- 101000721642 Homo sapiens Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Proteins 0.000 claims description 8
- 101000721645 Homo sapiens Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Proteins 0.000 claims description 8
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims description 8
- 101000983583 Homo sapiens Procathepsin L Proteins 0.000 claims description 8
- 101000684514 Homo sapiens Sentrin-specific protease 6 Proteins 0.000 claims description 8
- 101000708013 Homo sapiens Sentrin-specific protease 7 Proteins 0.000 claims description 8
- 101000708009 Homo sapiens Sentrin-specific protease 8 Proteins 0.000 claims description 8
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 claims description 8
- 101000691614 Homo sapiens Serine/threonine-protein kinase PLK3 Proteins 0.000 claims description 8
- 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 claims description 8
- 101000653005 Homo sapiens Thromboxane-A synthase Proteins 0.000 claims description 8
- 101000596771 Homo sapiens Transcription factor 7-like 2 Proteins 0.000 claims description 8
- 101001022129 Homo sapiens Tyrosine-protein kinase Fyn Proteins 0.000 claims description 8
- 101001054878 Homo sapiens Tyrosine-protein kinase Lyn Proteins 0.000 claims description 8
- 101000939517 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Proteins 0.000 claims description 8
- 101000804798 Homo sapiens Werner syndrome ATP-dependent helicase Proteins 0.000 claims description 8
- 101150087850 Htr5b gene Proteins 0.000 claims description 8
- 102000001284 I-kappa-B kinase Human genes 0.000 claims description 8
- 108060006678 I-kappa-B kinase Proteins 0.000 claims description 8
- 102100021857 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Human genes 0.000 claims description 8
- 102100036721 Insulin receptor Human genes 0.000 claims description 8
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 claims description 8
- 102100033342 Lysosomal acid glucosylceramidase Human genes 0.000 claims description 8
- 102100034069 MAP kinase-activated protein kinase 2 Human genes 0.000 claims description 8
- 108010041955 MAP-kinase-activated kinase 2 Proteins 0.000 claims description 8
- 108700012928 MAPK14 Proteins 0.000 claims description 8
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims description 8
- 101150003941 Mapk14 gene Proteins 0.000 claims description 8
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims description 8
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims description 8
- 108010093662 Member 11 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims description 8
- 108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims description 8
- 102100026932 Mitogen-activated protein kinase 12 Human genes 0.000 claims description 8
- 102000054819 Mitogen-activated protein kinase 14 Human genes 0.000 claims description 8
- 102100029565 NPC intracellular cholesterol transporter 1 Human genes 0.000 claims description 8
- 102100030411 Neutrophil collagenase Human genes 0.000 claims description 8
- 108010015181 PPAR delta Proteins 0.000 claims description 8
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 claims description 8
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 claims description 8
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims description 8
- 102100036061 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Human genes 0.000 claims description 8
- 102100036052 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Human genes 0.000 claims description 8
- 102100025058 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Human genes 0.000 claims description 8
- 102100025059 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Human genes 0.000 claims description 8
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims description 8
- 108010012887 Poly(A)-Binding Protein I Proteins 0.000 claims description 8
- 102100026090 Polyadenylate-binding protein 1 Human genes 0.000 claims description 8
- 102100026534 Procathepsin L Human genes 0.000 claims description 8
- 102000001332 SRC Human genes 0.000 claims description 8
- 108060006706 SRC Proteins 0.000 claims description 8
- 102100023713 Sentrin-specific protease 6 Human genes 0.000 claims description 8
- 102100031406 Sentrin-specific protease 7 Human genes 0.000 claims description 8
- 102100031407 Sentrin-specific protease 8 Human genes 0.000 claims description 8
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 claims description 8
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 claims description 8
- 102100026209 Serine/threonine-protein kinase PLK3 Human genes 0.000 claims description 8
- 102100030416 Stromelysin-1 Human genes 0.000 claims description 8
- 102100030973 Thromboxane-A synthase Human genes 0.000 claims description 8
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims description 8
- 102100035101 Transcription factor 7-like 2 Human genes 0.000 claims description 8
- 102100035221 Tyrosine-protein kinase Fyn Human genes 0.000 claims description 8
- 102100026857 Tyrosine-protein kinase Lyn Human genes 0.000 claims description 8
- 102100029643 Ubiquitin carboxyl-terminal hydrolase 2 Human genes 0.000 claims description 8
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 claims description 8
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims description 8
- 102100035336 Werner syndrome ATP-dependent helicase Human genes 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims description 8
- 108010056274 polo-like kinase 1 Proteins 0.000 claims description 8
- 238000011084 recovery Methods 0.000 claims description 8
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 7
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 6
- 208000004300 Atrophic Gastritis Diseases 0.000 claims description 6
- 208000004894 Camptocormia Diseases 0.000 claims description 6
- 206010067468 Dopamine dysregulation syndrome Diseases 0.000 claims description 6
- 208000036495 Gastritis atrophic Diseases 0.000 claims description 6
- 206010018341 Gliosis Diseases 0.000 claims description 6
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 6
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims description 6
- 230000007387 gliosis Effects 0.000 claims description 6
- 210000002216 heart Anatomy 0.000 claims description 6
- 201000006370 kidney failure Diseases 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 239000012453 solvate Substances 0.000 claims description 6
- 238000001356 surgical procedure Methods 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 208000023105 Huntington disease Diseases 0.000 claims description 5
- 206010040954 Skin wrinkling Diseases 0.000 claims description 5
- 230000003920 cognitive function Effects 0.000 claims description 5
- 230000006870 function Effects 0.000 claims description 5
- 230000036541 health Effects 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 239000000651 prodrug Substances 0.000 claims description 5
- 229940002612 prodrug Drugs 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 230000037303 wrinkles Effects 0.000 claims description 5
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 4
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 4
- 206010021639 Incontinence Diseases 0.000 claims description 4
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 206010028289 Muscle atrophy Diseases 0.000 claims description 4
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims description 4
- 208000001280 Prediabetic State Diseases 0.000 claims description 4
- 206010039966 Senile dementia Diseases 0.000 claims description 4
- 206010039984 Senile osteoporosis Diseases 0.000 claims description 4
- 206010046543 Urinary incontinence Diseases 0.000 claims description 4
- 201000007201 aphasia Diseases 0.000 claims description 4
- 206010003246 arthritis Diseases 0.000 claims description 4
- 235000013861 fat-free Nutrition 0.000 claims description 4
- 210000000474 heel Anatomy 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 4
- 239000011707 mineral Substances 0.000 claims description 4
- 201000000585 muscular atrophy Diseases 0.000 claims description 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 4
- 201000009104 prediabetes syndrome Diseases 0.000 claims description 4
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 4
- 230000002739 subcortical effect Effects 0.000 claims description 4
- 230000000542 thalamic effect Effects 0.000 claims description 4
- 201000002832 Lewy body dementia Diseases 0.000 claims description 3
- 230000000593 degrading effect Effects 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 230000003902 lesion Effects 0.000 claims description 3
- 102100034452 Alternative prion protein Human genes 0.000 claims description 2
- 208000027896 Aortic valve disease Diseases 0.000 claims description 2
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims description 2
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 2
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 2
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
- 206010012218 Delirium Diseases 0.000 claims description 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 2
- 206010027304 Menopausal symptoms Diseases 0.000 claims description 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims description 2
- 206010049088 Osteopenia Diseases 0.000 claims description 2
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims description 2
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 2
- 108091000054 Prion Proteins 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 230000037182 bone density Effects 0.000 claims description 2
- 210000000459 calcaneus Anatomy 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 230000008030 elimination Effects 0.000 claims description 2
- 238000003379 elimination reaction Methods 0.000 claims description 2
- 210000004209 hair Anatomy 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 230000037323 metabolic rate Effects 0.000 claims description 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 230000001850 reproductive effect Effects 0.000 claims description 2
- 230000035488 systolic blood pressure Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 102000005030 SLC6A2 Human genes 0.000 claims 4
- 102000005029 SLC6A3 Human genes 0.000 claims 4
- 102000005038 SLC6A4 Human genes 0.000 claims 4
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 claims 2
- 102100021782 SH3 domain-containing protein 19 Human genes 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 description 57
- 230000002354 daily effect Effects 0.000 description 42
- 239000003795 chemical substances by application Substances 0.000 description 37
- 208000019693 Lung disease Diseases 0.000 description 28
- 238000012544 monitoring process Methods 0.000 description 25
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 21
- 208000037765 diseases and disorders Diseases 0.000 description 21
- 208000036971 interstitial lung disease 2 Diseases 0.000 description 21
- 239000003814 drug Substances 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 18
- 210000001508 eye Anatomy 0.000 description 18
- 208000027866 inflammatory disease Diseases 0.000 description 18
- 230000002829 reductive effect Effects 0.000 description 18
- 102000006441 Dopamine Plasma Membrane Transport Proteins Human genes 0.000 description 17
- 206010027476 Metastases Diseases 0.000 description 17
- 102000008092 Norepinephrine Plasma Membrane Transport Proteins Human genes 0.000 description 17
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 description 17
- 210000004072 lung Anatomy 0.000 description 17
- 230000009401 metastasis Effects 0.000 description 16
- 235000018102 proteins Nutrition 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 16
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 15
- 229940079593 drug Drugs 0.000 description 15
- 230000002147 killing effect Effects 0.000 description 15
- 239000000779 smoke Substances 0.000 description 14
- 201000004624 Dermatitis Diseases 0.000 description 13
- 208000010412 Glaucoma Diseases 0.000 description 13
- 206010061218 Inflammation Diseases 0.000 description 13
- 206010023509 Kyphosis Diseases 0.000 description 13
- 208000012902 Nervous system disease Diseases 0.000 description 13
- 201000004681 Psoriasis Diseases 0.000 description 13
- 230000004054 inflammatory process Effects 0.000 description 13
- 210000002161 motor neuron Anatomy 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 238000002405 diagnostic procedure Methods 0.000 description 12
- 230000002757 inflammatory effect Effects 0.000 description 12
- 230000000670 limiting effect Effects 0.000 description 12
- 230000004770 neurodegeneration Effects 0.000 description 12
- 206010039073 rheumatoid arthritis Diseases 0.000 description 12
- 102100026189 Beta-galactosidase Human genes 0.000 description 11
- 201000004569 Blindness Diseases 0.000 description 11
- 102100038719 Histone deacetylase 7 Human genes 0.000 description 11
- 239000003623 enhancer Substances 0.000 description 11
- 208000023275 Autoimmune disease Diseases 0.000 description 10
- 102000008186 Collagen Human genes 0.000 description 10
- 108010035532 Collagen Proteins 0.000 description 10
- 208000025966 Neurological disease Diseases 0.000 description 10
- 206010064930 age-related macular degeneration Diseases 0.000 description 10
- 208000010668 atopic eczema Diseases 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
- 210000000988 bone and bone Anatomy 0.000 description 10
- 229920001436 collagen Polymers 0.000 description 10
- 230000004438 eyesight Effects 0.000 description 10
- 239000003112 inhibitor Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 231100000331 toxic Toxicity 0.000 description 10
- 230000002588 toxic effect Effects 0.000 description 10
- 102000004127 Cytokines Human genes 0.000 description 9
- 108090000695 Cytokines Proteins 0.000 description 9
- 230000001684 chronic effect Effects 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- 201000010041 presbyopia Diseases 0.000 description 9
- 230000009327 senolytic effect Effects 0.000 description 9
- 238000011269 treatment regimen Methods 0.000 description 9
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 230000003862 health status Effects 0.000 description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 7
- 206010033128 Ovarian cancer Diseases 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 7
- 229940045799 anthracyclines and related substance Drugs 0.000 description 7
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 7
- 210000004204 blood vessel Anatomy 0.000 description 7
- 230000010094 cellular senescence Effects 0.000 description 7
- 230000000973 chemotherapeutic effect Effects 0.000 description 7
- 210000000695 crystalline len Anatomy 0.000 description 7
- 206010022000 influenza Diseases 0.000 description 7
- 208000015122 neurodegenerative disease Diseases 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 230000004393 visual impairment Effects 0.000 description 7
- 206010048610 Cardiotoxicity Diseases 0.000 description 6
- 206010014561 Emphysema Diseases 0.000 description 6
- 206010016654 Fibrosis Diseases 0.000 description 6
- 208000008839 Kidney Neoplasms Diseases 0.000 description 6
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 description 6
- 206010036346 Posterior capsule opacification Diseases 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- 206010038389 Renal cancer Diseases 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 6
- 230000007059 acute toxicity Effects 0.000 description 6
- 231100000403 acute toxicity Toxicity 0.000 description 6
- 210000001367 artery Anatomy 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- 230000000747 cardiac effect Effects 0.000 description 6
- 231100000259 cardiotoxicity Toxicity 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 208000037976 chronic inflammation Diseases 0.000 description 6
- 230000009850 completed effect Effects 0.000 description 6
- 208000016097 disease of metabolism Diseases 0.000 description 6
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
- 229960004679 doxorubicin Drugs 0.000 description 6
- 230000004761 fibrosis Effects 0.000 description 6
- 230000001771 impaired effect Effects 0.000 description 6
- 201000010982 kidney cancer Diseases 0.000 description 6
- 238000002483 medication Methods 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 230000036407 pain Effects 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 230000000770 proinflammatory effect Effects 0.000 description 6
- 230000035755 proliferation Effects 0.000 description 6
- 208000005069 pulmonary fibrosis Diseases 0.000 description 6
- 210000002345 respiratory system Anatomy 0.000 description 6
- 208000002320 spinal muscular atrophy Diseases 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 description 5
- 206010002383 Angina Pectoris Diseases 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 5
- 208000003174 Brain Neoplasms Diseases 0.000 description 5
- 102100033868 Cannabinoid receptor 1 Human genes 0.000 description 5
- 206010007559 Cardiac failure congestive Diseases 0.000 description 5
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 5
- 206010009944 Colon cancer Diseases 0.000 description 5
- 102100027907 Cytoplasmic tyrosine-protein kinase BMX Human genes 0.000 description 5
- 206010048768 Dermatosis Diseases 0.000 description 5
- 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 description 5
- 101710131668 Epithelial discoidin domain-containing receptor 1 Proteins 0.000 description 5
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 5
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 5
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 101000988577 Homo sapiens 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 description 5
- 101000710899 Homo sapiens Cannabinoid receptor 1 Proteins 0.000 description 5
- 101000935548 Homo sapiens Cytoplasmic tyrosine-protein kinase BMX Proteins 0.000 description 5
- 101000926939 Homo sapiens Glucocorticoid receptor Proteins 0.000 description 5
- 101001005556 Homo sapiens Mitogen-activated protein kinase kinase kinase 19 Proteins 0.000 description 5
- 101001116937 Homo sapiens Protocadherin alpha-4 Proteins 0.000 description 5
- 101000648174 Homo sapiens Serine/threonine-protein kinase 10 Proteins 0.000 description 5
- 101000628647 Homo sapiens Serine/threonine-protein kinase 24 Proteins 0.000 description 5
- 101000631760 Homo sapiens Sodium channel protein type 1 subunit alpha Proteins 0.000 description 5
- 101000684826 Homo sapiens Sodium channel protein type 2 subunit alpha Proteins 0.000 description 5
- 101000684820 Homo sapiens Sodium channel protein type 3 subunit alpha Proteins 0.000 description 5
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 5
- 101000823271 Homo sapiens Tyrosine-protein kinase ABL2 Proteins 0.000 description 5
- 101000984551 Homo sapiens Tyrosine-protein kinase Blk Proteins 0.000 description 5
- 102100025217 Mitogen-activated protein kinase kinase kinase 19 Human genes 0.000 description 5
- 244000061176 Nicotiana tabacum Species 0.000 description 5
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 5
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 5
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 5
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 description 5
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 description 5
- 102100028900 Serine/threonine-protein kinase 10 Human genes 0.000 description 5
- 102100026764 Serine/threonine-protein kinase 24 Human genes 0.000 description 5
- 102100028910 Sodium channel protein type 1 subunit alpha Human genes 0.000 description 5
- 102100023150 Sodium channel protein type 2 subunit alpha Human genes 0.000 description 5
- 102100023720 Sodium channel protein type 3 subunit alpha Human genes 0.000 description 5
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 description 5
- 102100022651 Tyrosine-protein kinase ABL2 Human genes 0.000 description 5
- 102100027053 Tyrosine-protein kinase Blk Human genes 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 210000001185 bone marrow Anatomy 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 229940044683 chemotherapy drug Drugs 0.000 description 5
- 230000006020 chronic inflammation Effects 0.000 description 5
- 235000019504 cigarettes Nutrition 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 230000004064 dysfunction Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 208000014829 head and neck neoplasm Diseases 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 210000002414 leg Anatomy 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 238000002595 magnetic resonance imaging Methods 0.000 description 5
- 238000011275 oncology therapy Methods 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 208000017520 skin disease Diseases 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 201000004384 Alopecia Diseases 0.000 description 4
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 4
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 4
- 206010006100 Bradykinesia Diseases 0.000 description 4
- 208000025721 COVID-19 Diseases 0.000 description 4
- 206010008342 Cervix carcinoma Diseases 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 4
- 201000003883 Cystic fibrosis Diseases 0.000 description 4
- 206010056340 Diabetic ulcer Diseases 0.000 description 4
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 4
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 description 4
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 4
- 208000006083 Hypokinesia Diseases 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 4
- 108090001061 Insulin Proteins 0.000 description 4
- 208000007766 Kaposi sarcoma Diseases 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- 206010025323 Lymphomas Diseases 0.000 description 4
- 206010025421 Macule Diseases 0.000 description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 4
- 206010035664 Pneumonia Diseases 0.000 description 4
- 208000024313 Testicular Neoplasms Diseases 0.000 description 4
- 206010057644 Testis cancer Diseases 0.000 description 4
- 208000024770 Thyroid neoplasm Diseases 0.000 description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 4
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000003542 behavioural effect Effects 0.000 description 4
- 201000009267 bronchiectasis Diseases 0.000 description 4
- 230000009787 cardiac fibrosis Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 201000010881 cervical cancer Diseases 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 230000006735 deficit Effects 0.000 description 4
- 230000003292 diminished effect Effects 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 201000004101 esophageal cancer Diseases 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 230000003176 fibrotic effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 4
- 210000001320 hippocampus Anatomy 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 229940125396 insulin Drugs 0.000 description 4
- 201000007270 liver cancer Diseases 0.000 description 4
- 208000014018 liver neoplasm Diseases 0.000 description 4
- 201000005202 lung cancer Diseases 0.000 description 4
- 208000020816 lung neoplasm Diseases 0.000 description 4
- 206010025135 lupus erythematosus Diseases 0.000 description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
- 201000001441 melanoma Diseases 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 230000006764 neuronal dysfunction Effects 0.000 description 4
- 230000003349 osteoarthritic effect Effects 0.000 description 4
- 201000002528 pancreatic cancer Diseases 0.000 description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 208000030613 peripheral artery disease Diseases 0.000 description 4
- 230000037081 physical activity Effects 0.000 description 4
- 210000000229 preadipocyte Anatomy 0.000 description 4
- 238000011321 prophylaxis Methods 0.000 description 4
- 206010037844 rash Diseases 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 206010041823 squamous cell carcinoma Diseases 0.000 description 4
- 201000003120 testicular cancer Diseases 0.000 description 4
- 208000008732 thymoma Diseases 0.000 description 4
- 201000002510 thyroid cancer Diseases 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 230000009184 walking Effects 0.000 description 4
- 208000016261 weight loss Diseases 0.000 description 4
- 230000004580 weight loss Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 208000004611 Abdominal Obesity Diseases 0.000 description 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 3
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 3
- 206010005003 Bladder cancer Diseases 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 208000031229 Cardiomyopathies Diseases 0.000 description 3
- 208000014882 Carotid artery disease Diseases 0.000 description 3
- 206010065941 Central obesity Diseases 0.000 description 3
- 206010008469 Chest discomfort Diseases 0.000 description 3
- 206010009900 Colitis ulcerative Diseases 0.000 description 3
- 102000004266 Collagen Type IV Human genes 0.000 description 3
- 108010042086 Collagen Type IV Proteins 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 208000011231 Crohn disease Diseases 0.000 description 3
- 206010011878 Deafness Diseases 0.000 description 3
- 108700019745 Disks Large Homolog 4 Proteins 0.000 description 3
- 102000047174 Disks Large Homolog 4 Human genes 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 206010014733 Endometrial cancer Diseases 0.000 description 3
- 206010014759 Endometrial neoplasm Diseases 0.000 description 3
- 208000004930 Fatty Liver Diseases 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 208000031226 Hyperlipidaemia Diseases 0.000 description 3
- 108090001005 Interleukin-6 Proteins 0.000 description 3
- 102000004889 Interleukin-6 Human genes 0.000 description 3
- 208000003445 Mouth Neoplasms Diseases 0.000 description 3
- 206010028116 Mucosal inflammation Diseases 0.000 description 3
- 201000010927 Mucositis Diseases 0.000 description 3
- 208000034578 Multiple myelomas Diseases 0.000 description 3
- 208000007256 Nevus Diseases 0.000 description 3
- 229930012538 Paclitaxel Natural products 0.000 description 3
- 208000018262 Peripheral vascular disease Diseases 0.000 description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 208000000453 Skin Neoplasms Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 206010043515 Throat cancer Diseases 0.000 description 3
- 206010044565 Tremor Diseases 0.000 description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 230000035508 accumulation Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 238000002583 angiography Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000001130 astrocyte Anatomy 0.000 description 3
- 230000037444 atrophy Effects 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 208000026106 cerebrovascular disease Diseases 0.000 description 3
- 208000011654 childhood malignant neoplasm Diseases 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 229960003638 dopamine Drugs 0.000 description 3
- 208000011325 dry age related macular degeneration Diseases 0.000 description 3
- 230000010393 epithelial cell migration Effects 0.000 description 3
- 230000007705 epithelial mesenchymal transition Effects 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 201000010536 head and neck cancer Diseases 0.000 description 3
- 230000010370 hearing loss Effects 0.000 description 3
- 231100000888 hearing loss Toxicity 0.000 description 3
- 208000016354 hearing loss disease Diseases 0.000 description 3
- 210000001624 hip Anatomy 0.000 description 3
- 210000005260 human cell Anatomy 0.000 description 3
- 208000000069 hyperpigmentation Diseases 0.000 description 3
- 230000003810 hyperpigmentation Effects 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000004199 lung function Effects 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000015654 memory Effects 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 208000005264 motor neuron disease Diseases 0.000 description 3
- 210000002682 neurofibrillary tangle Anatomy 0.000 description 3
- 201000008968 osteosarcoma Diseases 0.000 description 3
- 208000035824 paresthesia Diseases 0.000 description 3
- 230000001144 postural effect Effects 0.000 description 3
- 230000009325 pulmonary function Effects 0.000 description 3
- 230000008085 renal dysfunction Effects 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 208000013220 shortness of breath Diseases 0.000 description 3
- 238000009097 single-agent therapy Methods 0.000 description 3
- 201000000849 skin cancer Diseases 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- 208000003265 stomatitis Diseases 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 201000005112 urinary bladder cancer Diseases 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- ZQAQXZBSGZUUNL-BJUDXGSMSA-N 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol Chemical compound C1=CC(N[11CH3])=CC=C1C1=NC2=CC=C(O)C=C2S1 ZQAQXZBSGZUUNL-BJUDXGSMSA-N 0.000 description 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- 208000032467 Aplastic anaemia Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
- 206010005949 Bone cancer Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 206010006448 Bronchiolitis Diseases 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 208000025678 Ciliary Motility disease Diseases 0.000 description 2
- 208000010200 Cockayne syndrome Diseases 0.000 description 2
- 208000028698 Cognitive impairment Diseases 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 206010053138 Congenital aplastic anaemia Diseases 0.000 description 2
- 206010011091 Coronary artery thrombosis Diseases 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- 206010052337 Diastolic dysfunction Diseases 0.000 description 2
- 206010013886 Dysaesthesia Diseases 0.000 description 2
- 206010013887 Dysarthria Diseases 0.000 description 2
- 208000032928 Dyslipidaemia Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 201000004939 Fanconi anemia Diseases 0.000 description 2
- 208000003098 Ganglion Cysts Diseases 0.000 description 2
- 208000022461 Glomerular disease Diseases 0.000 description 2
- 206010019196 Head injury Diseases 0.000 description 2
- 208000013875 Heart injury Diseases 0.000 description 2
- 208000017604 Hodgkin disease Diseases 0.000 description 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
- 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 description 2
- 208000025500 Hutchinson-Gilford progeria syndrome Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 206010023825 Laryngeal cancer Diseases 0.000 description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 description 2
- 206010073059 Malignant neoplasm of unknown primary site Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 102000005741 Metalloproteases Human genes 0.000 description 2
- 108010006035 Metalloproteases Proteins 0.000 description 2
- 208000002740 Muscle Rigidity Diseases 0.000 description 2
- 206010049565 Muscle fatigue Diseases 0.000 description 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 description 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 2
- 206010061309 Neoplasm progression Diseases 0.000 description 2
- 206010058105 Neutrophilic dermatosis Diseases 0.000 description 2
- 206010073310 Occupational exposures Diseases 0.000 description 2
- 208000022873 Ocular disease Diseases 0.000 description 2
- 206010030348 Open-Angle Glaucoma Diseases 0.000 description 2
- 206010034277 Pemphigoid Diseases 0.000 description 2
- 241000721454 Pemphigus Species 0.000 description 2
- 206010034972 Photosensitivity reaction Diseases 0.000 description 2
- 101000612288 Pinus strobus Putative oxygen-evolving enhancer protein 1 Proteins 0.000 description 2
- 102100022033 Presenilin-1 Human genes 0.000 description 2
- 208000032319 Primary lateral sclerosis Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000007932 Progeria Diseases 0.000 description 2
- 108010001267 Protein Subunits Proteins 0.000 description 2
- 102000002067 Protein Subunits Human genes 0.000 description 2
- 208000032225 Proximal spinal muscular atrophy type 1 Diseases 0.000 description 2
- 208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 2
- 208000037656 Respiratory Sounds Diseases 0.000 description 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 description 2
- 206010061934 Salivary gland cancer Diseases 0.000 description 2
- 208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 208000005400 Synovial Cyst Diseases 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 201000009365 Thymic carcinoma Diseases 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 108090000848 Ubiquitin Proteins 0.000 description 2
- 102000044159 Ubiquitin Human genes 0.000 description 2
- 206010046298 Upper motor neurone lesion Diseases 0.000 description 2
- 208000024780 Urticaria Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000026481 Werdnig-Hoffmann disease Diseases 0.000 description 2
- 201000011032 Werner Syndrome Diseases 0.000 description 2
- 206010047924 Wheezing Diseases 0.000 description 2
- 230000001594 aberrant effect Effects 0.000 description 2
- 208000020990 adrenal cortex carcinoma Diseases 0.000 description 2
- 208000007128 adrenocortical carcinoma Diseases 0.000 description 2
- 210000004504 adult stem cell Anatomy 0.000 description 2
- 230000007172 age related pathology Effects 0.000 description 2
- 230000006933 amyloid-beta aggregation Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 208000007474 aortic aneurysm Diseases 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 210000002469 basement membrane Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 2
- 229960001467 bortezomib Drugs 0.000 description 2
- 230000003925 brain function Effects 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 2
- 230000009084 cardiovascular function Effects 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 210000003710 cerebral cortex Anatomy 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 235000019506 cigar Nutrition 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 208000004209 confusion Diseases 0.000 description 2
- 208000002528 coronary thrombosis Diseases 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 229960000975 daunorubicin Drugs 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 206010013395 disorientation Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 206010014665 endocarditis Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 230000002327 eosinophilic effect Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 238000009093 first-line therapy Methods 0.000 description 2
- 239000003517 fume Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 2
- 229960005277 gemcitabine Drugs 0.000 description 2
- 231100000852 glomerular disease Toxicity 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 201000009277 hairy cell leukemia Diseases 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 201000005787 hematologic cancer Diseases 0.000 description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 235000021070 high sugar diet Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 231100001039 immunological change Toxicity 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 201000004815 juvenile spinal muscular atrophy Diseases 0.000 description 2
- 206010023841 laryngeal neoplasm Diseases 0.000 description 2
- 201000010901 lateral sclerosis Diseases 0.000 description 2
- 229960004942 lenalidomide Drugs 0.000 description 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 2
- 210000001542 lens epithelial cell Anatomy 0.000 description 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000006738 locomotor deficit Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 208000006178 malignant mesothelioma Diseases 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 108091070501 miRNA Proteins 0.000 description 2
- 230000007659 motor function Effects 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 201000005962 mycosis fungoides Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000000414 obstructive effect Effects 0.000 description 2
- 231100000675 occupational exposure Toxicity 0.000 description 2
- 208000005207 oral submucous fibrosis Diseases 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 210000000608 photoreceptor cell Anatomy 0.000 description 2
- 230000036211 photosensitivity Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 229960000688 pomalidomide Drugs 0.000 description 2
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 description 2
- 238000012636 positron electron tomography Methods 0.000 description 2
- 201000009266 primary ciliary dyskinesia Diseases 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000018329 progeroid syndrome Diseases 0.000 description 2
- 201000002241 progressive bulbar palsy Diseases 0.000 description 2
- 201000008752 progressive muscular atrophy Diseases 0.000 description 2
- 210000001176 projection neuron Anatomy 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000011127 radiochemotherapy Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 201000002793 renal fibrosis Diseases 0.000 description 2
- 230000000979 retarding effect Effects 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 2
- 229940125381 senolytic agent Drugs 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 208000026473 slurred speech Diseases 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 201000011549 stomach cancer Diseases 0.000 description 2
- 230000007755 survival signaling Effects 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000005751 tumor progression Effects 0.000 description 2
- 208000032471 type 1 spinal muscular atrophy Diseases 0.000 description 2
- 208000032527 type III spinal muscular atrophy Diseases 0.000 description 2
- 230000003827 upregulation Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- ZVECSLHUCRIBDY-WMWQKROPSA-N 5-[(e)-2-[3-bromo-4-[(e)-2-(3-carboxy-4-hydroxyphenyl)ethenyl]phenyl]ethenyl]-2-hydroxybenzoic acid Chemical compound C1=C(O)C(C(=O)O)=CC(\C=C\C=2C=C(Br)C(\C=C\C=3C=C(C(O)=CC=3)C(O)=O)=CC=2)=C1 ZVECSLHUCRIBDY-WMWQKROPSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000159 Abnormal loss of weight Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 102100026882 Alpha-synuclein Human genes 0.000 description 1
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
- 206010061424 Anal cancer Diseases 0.000 description 1
- 208000007860 Anus Neoplasms Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 description 1
- 206010073360 Appendix cancer Diseases 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 208000033116 Asbestos intoxication Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 201000008271 Atypical teratoid rhabdoid tumor Diseases 0.000 description 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 206010004593 Bile duct cancer Diseases 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010051728 Bone erosion Diseases 0.000 description 1
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 208000008516 Capsule Opacification Diseases 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010007275 Carcinoid tumour Diseases 0.000 description 1
- 206010007279 Carcinoid tumour of the gastrointestinal tract Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010007764 Cataract subcapsular Diseases 0.000 description 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 1
- 208000037138 Central nervous system embryonal tumor Diseases 0.000 description 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
- 201000009047 Chordoma Diseases 0.000 description 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 206010009691 Clubbing Diseases 0.000 description 1
- 241001573498 Compacta Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 208000009798 Craniopharyngioma Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 description 1
- 102000011799 Desmoglein Human genes 0.000 description 1
- 108050002238 Desmoglein Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 206010013142 Disinhibition Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102100023387 Endoribonuclease Dicer Human genes 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000012468 Ewing sarcoma/peripheral primitive neuroectodermal tumor Diseases 0.000 description 1
- 208000017259 Extragonadal germ cell tumor Diseases 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010017088 Fracture nonunion Diseases 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 206010059024 Gastrointestinal toxicity Diseases 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 208000021309 Germ cell tumor Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 102100039993 Hairy/enhancer-of-split related with YRPW motif-like protein Human genes 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 101150019344 Heyl gene Proteins 0.000 description 1
- 101000907904 Homo sapiens Endoribonuclease Dicer Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 description 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 description 1
- 206010021079 Hypopnoea Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 description 1
- 201000008450 Intracranial aneurysm Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000009164 Islet Cell Adenoma Diseases 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010023330 Keloid scar Diseases 0.000 description 1
- 208000027747 Kennedy disease Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 201000005099 Langerhans cell histiocytosis Diseases 0.000 description 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 description 1
- 206010062038 Lip neoplasm Diseases 0.000 description 1
- 206010073099 Lobular breast carcinoma in situ Diseases 0.000 description 1
- 206010025312 Lymphoma AIDS related Diseases 0.000 description 1
- 101710091439 Major capsid protein 1 Proteins 0.000 description 1
- 206010025557 Malignant fibrous histiocytoma of bone Diseases 0.000 description 1
- 208000032271 Malignant tumor of penis Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000027382 Mental deterioration Diseases 0.000 description 1
- 206010027374 Mental impairment Diseases 0.000 description 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
- 208000003430 Mitral Valve Prolapse Diseases 0.000 description 1
- 206010063914 Multimorbidity Diseases 0.000 description 1
- 206010028193 Multiple endocrine neoplasia syndromes Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101000794231 Mus musculus Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 206010028729 Nasal cavity cancer Diseases 0.000 description 1
- 206010028767 Nasal sinus cancer Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 1
- 102000008763 Neurofilament Proteins Human genes 0.000 description 1
- 108010088373 Neurofilament Proteins Proteins 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 208000000160 Olfactory Esthesioneuroblastoma Diseases 0.000 description 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 description 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 description 1
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 238000012879 PET imaging Methods 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 208000022599 Papulosquamous Skin disease Diseases 0.000 description 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 description 1
- 208000003937 Paranasal Sinus Neoplasms Diseases 0.000 description 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 description 1
- 208000002471 Penile Neoplasms Diseases 0.000 description 1
- 206010034299 Penile cancer Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010034811 Pharyngeal cancer Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 201000008199 Pleuropulmonary blastoma Diseases 0.000 description 1
- 208000010366 Postpoliomyelitis syndrome Diseases 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 208000037048 Prodromal Symptoms Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000033522 Proximal spinal muscular atrophy type 2 Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038669 Respiratory arrest Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 101100339680 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HRT3 gene Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 208000009359 Sezary Syndrome Diseases 0.000 description 1
- 201000010001 Silicosis Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010053262 Skin swelling Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 206010041243 Social avoidant behaviour Diseases 0.000 description 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 1
- 102100038836 Superoxide dismutase [Cu-Zn] Human genes 0.000 description 1
- 102000004874 Synaptophysin Human genes 0.000 description 1
- 108090001076 Synaptophysin Proteins 0.000 description 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 101710183280 Topoisomerase Proteins 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046392 Ureteric cancer Diseases 0.000 description 1
- 206010046431 Urethral cancer Diseases 0.000 description 1
- 206010046458 Urethral neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 208000005475 Vascular calcification Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010047741 Vulval cancer Diseases 0.000 description 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 description 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 1
- 208000008383 Wilms tumor Diseases 0.000 description 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000037236 achy joints Effects 0.000 description 1
- 208000009621 actinic keratosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000001056 activated astrocyte Anatomy 0.000 description 1
- 238000001994 activation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 108090000185 alpha-Synuclein Proteins 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- 230000003942 amyloidogenic effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 210000002159 anterior chamber Anatomy 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 201000011165 anus cancer Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000021780 appendiceal neoplasm Diseases 0.000 description 1
- 210000000617 arm Anatomy 0.000 description 1
- 206010003441 asbestosis Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000008335 axon cargo transport Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 210000004082 barrier epithelial cell Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 208000021138 brain aneurysm Diseases 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 210000001775 bruch membrane Anatomy 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 208000002458 carcinoid tumor Diseases 0.000 description 1
- 231100000457 cardiotoxic Toxicity 0.000 description 1
- 230000001451 cardiotoxic effect Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000011976 chest X-ray Methods 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 208000023973 childhood bladder carcinoma Diseases 0.000 description 1
- 201000004018 childhood brain stem glioma Diseases 0.000 description 1
- 208000026046 childhood carcinoid tumor Diseases 0.000 description 1
- 208000028191 childhood central nervous system germ cell tumor Diseases 0.000 description 1
- 208000015632 childhood ependymoma Diseases 0.000 description 1
- 208000013549 childhood kidney neoplasm Diseases 0.000 description 1
- 208000015576 childhood malignant melanoma Diseases 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 230000004456 color vision Effects 0.000 description 1
- 238000009096 combination chemotherapy Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 208000018631 connective tissue disease Diseases 0.000 description 1
- 230000006552 constitutive activation Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 101150069842 dlg4 gene Proteins 0.000 description 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
- 210000005064 dopaminergic neuron Anatomy 0.000 description 1
- 229940115080 doxil Drugs 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 description 1
- 238000002283 elective surgery Methods 0.000 description 1
- 238000002565 electrocardiography Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000004890 epithelial barrier function Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000005081 epithelial layer Anatomy 0.000 description 1
- 208000032099 esthesioneuroblastoma Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 201000008819 extrahepatic bile duct carcinoma Diseases 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 208000024519 eye neoplasm Diseases 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 208000015756 familial Alzheimer disease Diseases 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 210000004904 fingernail bed Anatomy 0.000 description 1
- 238000009541 flexible sigmoidoscopy Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 208000004104 gestational diabetes Diseases 0.000 description 1
- 201000007116 gestational trophoblastic neoplasm Diseases 0.000 description 1
- 238000007446 glucose tolerance test Methods 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 231100000226 haematotoxicity Toxicity 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 208000008675 hereditary spastic paraplegia Diseases 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 201000006866 hypopharynx cancer Diseases 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 201000002597 ichthyosis vulgaris Diseases 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 201000006913 intermediate spinal muscular atrophy Diseases 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 210000000244 kidney pelvis Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000004558 lewy body Anatomy 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 238000011542 limb amputation Methods 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 201000006721 lip cancer Diseases 0.000 description 1
- 230000006372 lipid accumulation Effects 0.000 description 1
- 230000000512 lipotoxic effect Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000018883 loss of balance Diseases 0.000 description 1
- 238000013123 lung function test Methods 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 208000026037 malignant tumor of neck Diseases 0.000 description 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 230000003818 metabolic dysfunction Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 230000006510 metastatic growth Effects 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 208000037970 metastatic squamous neck cancer Diseases 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000037230 mobility Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000037023 motor activity Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 206010051747 multiple endocrine neoplasia Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000020763 muscle atrophy Effects 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 208000026721 nail disease Diseases 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000478 neocortex Anatomy 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 201000008026 nephroblastoma Diseases 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 210000005044 neurofilament Anatomy 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 238000010855 neuropsychological testing Methods 0.000 description 1
- 229960000564 nitrofurantoin Drugs 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 238000013116 obese mouse model Methods 0.000 description 1
- 201000008106 ocular cancer Diseases 0.000 description 1
- 238000013536 ocular coherence tomography Methods 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 238000002577 ophthalmoscopy Methods 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000004768 organ dysfunction Effects 0.000 description 1
- 201000006958 oropharynx cancer Diseases 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 208000022102 pancreatic neuroendocrine neoplasm Diseases 0.000 description 1
- 208000021010 pancreatic neuroendocrine tumor Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 208000029211 papillomatosis Diseases 0.000 description 1
- 208000007312 paraganglioma Diseases 0.000 description 1
- 201000007052 paranasal sinus cancer Diseases 0.000 description 1
- FIKAKWIAUPDISJ-UHFFFAOYSA-L paraquat dichloride Chemical compound [Cl-].[Cl-].C1=C[N+](C)=CC=C1C1=CC=[N+](C)C=C1 FIKAKWIAUPDISJ-UHFFFAOYSA-L 0.000 description 1
- 201000000389 pediatric ependymoma Diseases 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000005043 peripheral vision Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000028591 pheochromocytoma Diseases 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 230000037074 physically active Effects 0.000 description 1
- 230000009894 physiological stress Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 208000010916 pituitary tumor Diseases 0.000 description 1
- 208000010626 plasma cell neoplasm Diseases 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000000711 polarimetry Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 210000003538 post-synaptic density Anatomy 0.000 description 1
- 108010092804 postsynaptic density proteins Proteins 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 206010036601 premature menopause Diseases 0.000 description 1
- 230000003518 presynaptic effect Effects 0.000 description 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 description 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 201000000196 pseudobulbar palsy Diseases 0.000 description 1
- 210000004879 pulmonary tissue Anatomy 0.000 description 1
- 210000002763 pyramidal cell Anatomy 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000008458 response to injury Effects 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 229940080817 rotenone Drugs 0.000 description 1
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 208000010157 sclerosing cholangitis Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000011571 secondary malignant neoplasm Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000000276 sedentary effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000026775 severe diarrhea Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 201000002314 small intestine cancer Diseases 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000013125 spirometry Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000011521 systemic chemotherapy Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 150000004579 taxol derivatives Chemical class 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000001585 trabecular meshwork Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 208000032521 type II spinal muscular atrophy Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000018417 undifferentiated high grade pleomorphic sarcoma of bone Diseases 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 208000037965 uterine sarcoma Diseases 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000016776 visual perception Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000021542 voluntary musculoskeletal movement Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2021103273 | 2021-02-10 | ||
RU2021103273 | 2021-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022173334A2 true WO2022173334A2 (fr) | 2022-08-18 |
Family
ID=82838891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2022/050045 WO2022173334A2 (fr) | 2021-02-10 | 2022-02-09 | Procédés, compositions et composés pour le traitement de maladies et d'états liés à l'âge |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2022173334A2 (fr) |
-
2022
- 2022-02-09 WO PCT/RU2022/050045 patent/WO2022173334A2/fr active Application Filing
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11963957B2 (en) | Treating cardiovascular disease by selectively eliminating senescent cells | |
US20230218617A1 (en) | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid | |
WO2022173333A2 (fr) | Composés, compositions et méthodes de traitement de maladies et d'états liés à l'âge | |
WO2022173334A2 (fr) | Procédés, compositions et composés pour le traitement de maladies et d'états liés à l'âge | |
WO2023014718A2 (fr) | 25-hydroxycholestérol (25 hc), inhibiteur d'agrégation de cryab pour améliorer la raideur vasculaire |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22753057 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 22753057 Country of ref document: EP Kind code of ref document: A2 |