WO2022159393A1 - Ambulatory device and components thereof - Google Patents

Ambulatory device and components thereof Download PDF

Info

Publication number
WO2022159393A1
WO2022159393A1 PCT/US2022/012795 US2022012795W WO2022159393A1 WO 2022159393 A1 WO2022159393 A1 WO 2022159393A1 US 2022012795 W US2022012795 W US 2022012795W WO 2022159393 A1 WO2022159393 A1 WO 2022159393A1
Authority
WO
WIPO (PCT)
Prior art keywords
connector
infusion
cartridge
medicament
docking station
Prior art date
Application number
PCT/US2022/012795
Other languages
French (fr)
Inventor
David Matthew HENDERSON
Edward R. DAMIANO
Firas H. EL-KHATIB
Bryan Dale Knodel
Original Assignee
Beta Bionics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beta Bionics, Inc. filed Critical Beta Bionics, Inc.
Priority to PCT/US2022/017368 priority Critical patent/WO2022178447A1/en
Priority to US17/654,776 priority patent/US20220199218A1/en
Priority to US17/654,913 priority patent/US20220208331A1/en
Priority to US17/655,122 priority patent/US20220208370A1/en
Priority to US17/656,356 priority patent/US11515027B2/en
Priority to US17/656,345 priority patent/US20220223251A1/en
Priority to PCT/US2022/071308 priority patent/WO2022204705A1/en
Priority to US17/656,849 priority patent/US20220222734A1/en
Priority to US17/657,105 priority patent/US20220218904A1/en
Priority to US17/657,263 priority patent/US20220223273A1/en
Priority to US17/657,547 priority patent/US20220223252A1/en
Priority to US17/657,607 priority patent/US20220218905A1/en
Priority to US17/657,612 priority patent/US11581080B2/en
Publication of WO2022159393A1 publication Critical patent/WO2022159393A1/en
Priority to US17/882,469 priority patent/US20230166035A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/105Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804Flow controllers
    • A61M5/16827Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1586Holding accessories for holding infusion needles on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1587Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1083Tube connectors; Tube couplings having a plurality of female connectors, e.g. Luer connectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1088Tube connectors; Tube couplings having a plurality of male connectors, e.g. Luer connectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/27General characteristics of the apparatus preventing use
    • A61M2205/276General characteristics of the apparatus preventing use preventing unwanted use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • A61M2205/505Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6045General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8206Internal energy supply devices battery-operated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1413Modular systems comprising interconnecting elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M5/1582Double lumen needles

Definitions

  • the disclosure relates generally to the field of medicament infusion systems (including systems configured to delivery multiple medicaments to a subject), components thereof (e.g., pump systems, cartridge connectors, cartridges, connector sets, multi-channel lumen assemblies, infusion sets, combinations of any of the foregoing, etc.), methods of making each of the foregoing, and methods of using each of the foregoing.
  • Sustained delivery, pump driven medicament injection devices generally include a delivery cannula mounted in a subcutaneous manner through the skin of the patient at an infusion site. The pump draws medicine from a reservoir and delivers it to the patient via the cannula.
  • the injection device typically includes a channel that transmits a medicament from an inlet port to the delivery cannula which results in delivery to the subcutaneous tissue layer where the delivery cannula terminates.
  • Some infusion devices are configured to deliver one medicament to a patient while others are configured to deliver multiple medicaments to patient.
  • SUMMARY [0004] Some embodiments herein provide medicament infusion systems (including systems configured to delivery multiple medicaments to a subject), components thereof (e.g., pump systems, cartridge connectors, cartridges, connector sets, multi-channel lumen assemblies, infusion sets, etc.), combinations of any one or more components, methods of making each of the foregoing, and methods of using each of the foregoing.
  • the infusion pump for delivering medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features.
  • the infusion pump comprises a pump housing.
  • the pump housing comprises a first receptacle port configured to engage a first cartridge connector.
  • the pump housing comprises a second receptacle port configured to engage a second cartridge connector.
  • the pump housing comprises a first medicament cartridge receptacle extending from the first receptacle port longitudinally along a first side of the infusion pump to a first cartridge receptacle aperture.
  • the pump housing comprises a second medicament cartridge receptacle extending from the second receptacle port longitudinally along a second side of the infusion pump to a second cartridge receptacle aperture.
  • the pump comprises an internal area.
  • the internal area comprises a power source.
  • the power source is located between the first medicament cartridge receptacle and the second medicament cartridge receptacle.
  • the internal area comprises a first motor in electronic communication with the power source.
  • the internal area comprises a second motor in electronic communication with the power source. In some embodiments, the internal area comprises a first stacked gear assembly. In some embodiments, the internal area comprises a second stacked gear assembly. In some embodiments, the internal area comprises a first lead screw. In some embodiments, the internal area comprises a second lead screw. In some embodiments, the power source is located between the first lead screw and the second lead screw. In some embodiments, the first motor comprises a first pinion gear, the first pinion gear being a member of the first stacked gear assembly. In some embodiments, the second motor (where present) comprises a second pinion gear (where present), the second pinion gear being a member of the second stacked gear assembly (where present).
  • the first gear assembly extends laterally toward the first side of the infusion pump. In some embodiments, the second gear assembly extends laterally toward the second side of the infusion pump. In some embodiments, the first lead screw is in rotational communication with the first pinion gear through the first gear assembly. In some embodiments, the second lead screw is in rotational communication with the second pinion gear through the second gear assembly. In some embodiments, the pump comprises a first drive nut having a length extending longitudinally along the pump housing. In some embodiments, the first drive nut is configured to travel into the first medicament cartridge receptacle via the first aperture.
  • the first drive nut is in communication with the first lead screw and is configured to urge forward or backward in response to a first direction of rotation and a second direction of rotation, respectively, of the first lead screw.
  • the pump comprises a second drive nut having a length extending longitudinally along the pump housing.
  • the second drive nut is configured to travel into the second medicament cartridge receptacle via the second aperture.
  • the second drive nut is in communication with the second lead screw and is configured to urge forward or backward in response to a first direction of rotation and a second direction of rotation, respectively, of the second lead screw.
  • the first receptacle port has one or more recognition features configured to engage with corresponding recognition features of the first cartridge connector.
  • the second receptacle port has one or more recognition features configured to engage with corresponding recognition features of the second cartridge connector.
  • the recognition features of the first receptacle port are different from the recognition features of the second receptacle port.
  • the first receptacle port is configured to not allow engagement of the second cartridge connector and the second receptacle port is configured to not allow engagement of the first cartridge connector.
  • the pump comprises a first seal and/or a second seal.
  • the first seal provides a water-resistant barrier between the internal area of the infusion pump and the first medicament cartridge receptacle.
  • the second seal provides a water-resistant barrier between the internal area of the infusion pump and the second medicament cartridge receptacle.
  • the first seal is a first O-ring that circumferentially surrounds at least a portion of the first drive nut.
  • the second seal is a second O-ring that circumferentially surrounds at least a portion of the second drive nut.
  • the pump housing comprises a first saddle.
  • the pump housing comprises a second saddle.
  • the first saddle is configured to retain the first O-ring.
  • the second saddle is configured to retain the second O- ring.
  • the first saddle is positioned adjacent to the first cartridge receptacle aperture.
  • the second saddle is positioned adjacent to the second cartridge receptacle aperture.
  • the first receptacle port comprises a snap arm recess extending longitudinally within the first medicament cartridge receptacle, the snap arm recess of the first medicament cartridge receptacle being configured to receive a snap arm of the first cartridge connector as the snap arm expands over a first medicament cartridge cap during engagement of a first medicament cartridge while the first medicament cartridge is housed in (e.g., positioned in, residing in, etc.) the first medicament cartridge receptacle.
  • the second receptacle port comprises a snap arm recess extending longitudinally within the second medicament cartridge receptacle, the snap arm recess of the second medicament cartridge receptacle being configured to receive a snap arm of the second cartridge connector as the snap arm expands over a second medicament cartridge cap during engagement of a second medicament cartridge while the second medicament cartridge is housed in (e.g., positioned in, residing in, etc.) the second medicament cartridge receptacle.
  • the snap arm recess of the first receptacle port is configured not to receive the snap arm of the second cartridge connector.
  • the first receptacle port comprises lug opening and a radially extending lug track configured to receive a lug of the first cartridge connector as the first cartridge connector is inserted into the first receptacle port and turned into place.
  • the second receptacle port comprises lug opening and a radially extending lug track configured to receive a lug of the second cartridge connector as the second cartridge connector is inserted into the second receptacle port and turned into place.
  • the first receptacle port comprises detent opening and a detent track.
  • the detent track comprises a detent cam with a shallow first transition and a steep second transition.
  • the detent opening and detent track are configured to receive a detent of the first cartridge connector as the first cartridge connector is inserted into the first receptacle port and turned into place.
  • the shallow first transition is configured to allow the detent of the first cartridge connector to be turned into place within the infusion pump with less force than is required to remove the first cartridge connector from the first receptacle port along the direction of the steep second transition.
  • the second receptacle port comprises detent opening and a detent track.
  • the detent track comprises a detent cam with a shallow first transition and a steep second transition.
  • the detent opening and detent track are configured to receive a detent of the second cartridge connector as the second cartridge connector is inserted into the second receptacle port and turned into place.
  • the shallow first transition is configured to allow the detent of the second cartridge connector to be turned into place within the infusion pump with less force than is required to remove the second cartridge connector from the second receptacle port along the direction of the steep second transition.
  • the cartridge receptacle is configured to not be sealed from the external environment (and/or are configured to allow pressure equilibrate between the atmosphere and the receptacle).
  • a cartridge connector does not provide an airtight seal when engaged to the infusion pump (e.g., it does not provide an air tight seal between the receptacle and the atmosphere around the infusion pump).
  • the cartridge chamber in the infusion pump may allow air and water to pass freely around the drug cartridges.
  • the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it to the hub via the coupling feature of the first docking station.
  • the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it to the hub via the coupling feature of the second docking station.
  • the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and configured to adhere the infusion site base to skin the patient.
  • the infusion site base comprises a coaxial delivery conduit extending distally from the hub and passed the adhesive (and/or through the adhesive).
  • the coaxial delivery conduit comprises a first tubular member having a first lumen and a second tubular member comprising a second lumen.
  • the second tubular member is disposed at least partially within the first lumen of the first tubular member of the coaxial delivery conduit.
  • the first lumen of the first tubular member is in fluidic communication with the port of the first docking station.
  • the second lumen of the second tubular member is in fluidic communication with the port of the second docking station.
  • the first and second docking stations may be present on the same or different surfaces of the hub.
  • the first docking station is located on or at a side surface of the hub.
  • the second docking station is located on an upper surface of the hub.
  • the first lumen of the first tubular member is not in fluidic communication with the second lumen of the second tubular member.
  • the first tubular member is flexible and/or the second tubular member is flexible.
  • the first tubular member is a cannula and/or the second tubular member is a cannula.
  • the first tubular member is rigid and/or the second tubular member is rigid.
  • the first tubular member is a needle and/or the second tubular member is a needle.
  • the second tubular member extends distally from the hub to a distance farther from the hub than a distance to which the first tubular member extends.
  • the second tubular member extends distally from the hub to a distance from the hub equal to a distance to which the first tubular member extends.
  • the second tubular member extends to a distance from the hub that is equal to or less than a distance to which the first tubular member extends.
  • the coaxial delivery conduit is at least partially disposed in the hub.
  • the coaxial delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient.
  • the infusion site base comprises a hub having an upper surface, a bottom surface, and a side surface.
  • the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it via the coupling feature of the first docking station.
  • the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it via the coupling feature of the second docking station.
  • the hub comprises an aperture that extends from the port of the second docking station, through the hub, the aperture being configured to receive a delivery conduit from the second infusion connector.
  • the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and is configured to adhere the infusion site base to skin the patient.
  • the infusion site base comprises a delivery conduit extending distally from the hub and passed the adhesive.
  • the delivery conduit comprising a first tubular member having a first lumen, the first lumen of the delivery conduit being in fluidic communication with the port of the first docking station via the fluid passage of the hub.
  • at least a portion of the delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient.
  • the first tubular member is flexible.
  • first tubular member is a cannula.
  • the first tubular member is rigid.
  • the first tubular member is a needle.
  • the aperture is configured to allow a piercing element of the second infusion connector to extend through the infusion set and into patient.
  • the aperture of the hub leads to and/or is in fluidic communication with an opening (e.g., aperture, mouth, etc.) of the first tubular member.
  • the aperture is configured to allow the delivery conduit from the second infusion connector to extend through the infusion set and into patient.
  • the delivery conduit from the second infusion connector when the second infusion connector is engaged with the hub, the delivery conduit from the second infusion connector provides a second tubular member disposed at least partially within the first lumen of the first tubular member, thereby providing a coaxial delivery conduit.
  • the infusion site base comprises a hub having an upper surface, a bottom surface, and a side surface.
  • the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it to the hub via the coupling feature of the first docking station.
  • the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it to the hub via the coupling feature of the second docking station.
  • the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and configured to adhere the infusion site base to skin the patient.
  • the infusion site base comprises a dual lumen delivery conduit extending distally from the hub and passed the adhesive.
  • the dual lumen delivery conduit comprises a first lumen and a second lumen.
  • the first lumen is in fluidic communication with the port of the first docking station.
  • the second lumen is in fluidic communication with the port of the second docking station.
  • the first docking station is located on the side surface of the hub and wherein the second docking station is located on an upper surface of the hub.
  • the first lumen is not in fluidic communication with the second lumen.
  • the dual lumen delivery conduit is flexible.
  • at least a portion of the dual lumen delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient.
  • the second docking station is located on the upper surface of the hub.
  • the first docking station comprises features that inhibit engagement of the second infusion connector to the first docking station.
  • the second docking station comprises features that inhibit engagement of the first infusion connector to the second docking station.
  • the system may comprise an infusion site base in combination with one or more of the components disclosed above or elsewhere herein.
  • the system comprises the infusion site base as disclosed above or elsewhere herein, the first infusion connector, and the second infusion connector.
  • the second infusion connector comprises a piercing element.
  • the piercing element of the second infusion connector passes through a port of the hub of the infusion site base.
  • the port of the second docking station (and/or of the first docking station) may comprise a pierceable element (e.g., a septum, an elastomeric seal, etc.).
  • the piercing element of the second infusion connector passes through the hub of the infusion site base.
  • the piercing element of the second infusion connector is a needle.
  • the piercing element of the second infusion connector when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub and into a delivery conduit of the infusion site base (e.g., a first tubular fluid conduit).
  • a delivery conduit of the infusion site base e.g., a first tubular fluid conduit.
  • the piercing element of the second infusion connector when the second infusion connector is engaged to the second docking station, passes through the hub and is located at a position laterally disposed from the first tubular fluid conduit.
  • the system comprises the infusion site base as disclosed above or elsewhere herein, the first infusion connector, and the second infusion connector.
  • the system further comprising a multi-channel lumen assembly, wherein the multi-channel lumen assembly comprises the first infusion connector and second infusion connector, the multi- channel lumen assembly comprising a first fluid conduit in fluidic communication with the first infusion connector and a second fluid conduit in fluidic communication with a second infusion connector.
  • the system further comprising a first reservoir connector in fluidic communication with the first infusion connector via the first fluid conduit of the multi-channel lumen assembly.
  • the system further comprises a second reservoir connector in fluidic communication with the second infusion connector via the second fluid conduit of the multi-channel lumen assembly.
  • the second fluid conduit of the multi-channel lumen assembly is disposed over the first fluid conduit of the multi-channel lumen assembly.
  • the infusion set comprises one or more of a first infusion connector, a second infusion connector, and an infusion site base. In several embodiments, the infusion set comprises one or more of a first infusion connector, a second infusion connector, and a multi-channel lumen assembly. In several embodiments, the infusion set comprises one or more of a first infusion connector, a second infusion connector, a multi-channel lumen assembly, and an infusion site base. In several embodiments, the infusion set comprises an adhesive portion configured to adhere the infusion set to skin the patient.
  • the infusion set comprises a hub having a top surface and a bottom surface, the bottom surface of the hub being proximal to the adhesive portion of the infusion set and the top surface being distal to the adhesive portion of the infusion set.
  • the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive the first infusion connector and to couple to it via the coupling feature of the first docking station.
  • the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive the second infusion connector and to couple to it via the coupling feature of the second docking station.
  • the infusion set comprises a coaxial delivery conduit extending distally from the hub, the coaxial delivery conduit comprising a first tubular member having a first lumen and a second tubular member comprising a second lumen, the second tubular member being disposed at least partially within the first lumen of the first tubular member.
  • the first lumen of the first tubular member is in fluidic communication with the port of the first docking station.
  • the coaxial delivery conduit extends distally from the adhesive portion and, when the infusion set is adhered to a skin of the patient, is configured to extend below a surface of the skin of the patient.
  • the first infusion connector comprises a first piercing member extending from a body of the first infusion connector infusion, the first piercing member having a lumen configured receive and to allow flow of a first medicament through the first infusion connector.
  • the piercing member extends axially (e.g., with respect to the fluid conduit) from the body of first infusion connecter.
  • the hub comprises a side surface extending between the upper surface and lower surface, the side surface comprising the first docking station.
  • the first piercing member upon coupling of the first infusion to the first docking station, extends through the port of the first docking station to provide fluidic communication between the lumen of the first piercing member and first lumen of the coaxial delivery conduit.
  • the port of the first docking station comprises a first septum configured to be pierced by the first piercing member upon connection between the first infusion connector to the infusion set.
  • the second infusion connector comprises a second piercing member extending from a body of the second infusion connector infusion, the second piercing member having a lumen configured receive and to allow flow of a second medicament through the second infusion connector.
  • the piercing member extends radially (e.g., with respect to the fluid conduit) from the body of second infusion connecter.
  • the port of the second docking station comprises a second septum configured to be pierced by the second piercing member upon connection between the second infusion connector to the infusion set.
  • the upper surface of the hub comprises the second docking station.
  • the second piercing member upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide fluidic communication between the lumen of the second piercing member and the second lumen of the coaxial delivery conduit.
  • the upper surface of the hub comprises the second docking station.
  • the second piercing member upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station. In several embodiments, upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide the lumen of the second piercing member and the second lumen of the coaxial delivery conduit. [0017]
  • a cartridge connector (and/or to a set of cartridge connectors). Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features.
  • the cartridge connector comprises a knob.
  • the knob comprises a surface portion having an upper side, a lower side, and a perimeter.
  • the knob comprises an upper knob portion extending distally from the upper side of the surface portion of the knob, the upper knob portion comprising an outlet port and an outlet fitting, the outlet fitting being circumferentially disposed around the outlet port, the outlet fitting being configured to engage a corresponding fitting of a fluid conduit of an infusion set such that, when the fitting of the fluid conduit is engaged to the outlet fitting, the cartridge connector and the fluid conduit of the infusion set are in fluidic communication.
  • the connector comprises a body extending distally from the lower side surface of the knob.
  • the body comprises a needle, a lower surface portion extending circumferentially from the needle, and a shroud extending axially away from the lower surface portion of the body and the lower side surface of the knob, the shroud being configured to engage a cap of a medicament cartridge when the medicament cartridge is inserted into the cartridge connector.
  • the lower surface portion of the body is located within the shroud.
  • the needle extends axially from the lower surface portion within the shroud and away from the lower surface portion of the body, the needle being configured to contact a medicament within the medicament cartridge when the medicament cartridge is inserted into the cartridge connector.
  • the upper knob portion comprises a length of fluid conduit extending distally from the surface portion and terminating at the outlet port and an outlet fitting of the upper knob portion.
  • the upper knob portion comprises a threaded shroud configured to engage the corresponding fitting of the fluid conduit of the infusion set.
  • the outlet fitting of the of the upper knob portion comprises a male receiving region.
  • the male receiving region is a male luer.
  • the male luer comprises an ISO 594- compliant luer taper.
  • the fitting of the fluid conduit of the infusion set is a female luer connector.
  • the surface portion of the knob extends outward from the upper knob portion.
  • the upper knob portion extends distally from the upper side surface portion of the knob at a position that is offset from a geometric center of the surface portion of the of the knob such that the upper knob portion is closer to one side of the perimeter of the surface portion than another side.
  • the perimeter of the surface portion comprises a flattened portion.
  • the knob is in a shape of a cam having the flattened portion.
  • the lower side of the knob extends circumferentially from the shroud of the body and wherein the lower side of the knob comprises one or more nubs.
  • the one or more nubs are configured to contact an upper side surface of an infusion pump, the one or more nubs providing one or more contact points between the lower surface of the knob and the infusion pump.
  • the nubs are deformable and/or are configured to deform when the cartridge connector is twisted into place within the infusion pump.
  • the lower surface portion of the body comprises a bowl-shaped concavity and a surrounding lip, wherein the needle protrudes from and extends away from the bowl-shaped concavity.
  • the body comprises a projection extending axially upwardly from an upper surface of the body.
  • the projection comprises a fluid outlet.
  • the body is configured to receive the medicament through the needle and to deliver the medicament out of the body from the fluid outlet of the body, the needle and the fluid outlet of the body being in fluidic communication and providing a fluid path through the body.
  • the knob comprises a receptacle section extending upwardly into the lower side of the knob, the receptacle section configured to extend over and receive at least a portion of the projection of the body.
  • the knob comprises a fluid inlet located within the receptacle section, the fluid inlet being configured to receive the medicament.
  • the knob comprises a fluid path configured to deliver the medicament to an outlet port of the knob.
  • the connector comprises an interstitial space located between the projection of the body and the receptacle section of the knob a flexible membrane located within the interstitial space and extending over at least a portion of the projection of the body, the flexible membrane being configured to allow fluid to pass from the body outlet and into the knob inlet only after a threshold fluid pressure of the medicament is reached.
  • the knob is fixed to and/or unitary with the body For instance, in several embodiments, the knob is heat staked to, welded to (e.g., ultrasonically welded), glued to, affixed to, or a part of the body.
  • the cartridge connector is configured to simultaneously engage the medicament cartridge and a port of an infusion pump.
  • the needle of the cartridge connector is configured to pierce a septum of the cap of the first medicament cartridge.
  • the shroud comprises one or more of a snap arm configured to engage the cap of the first medicament cartridge, a detent, and/or a lug.
  • the cartridge connector is configured to engage a first port of the infusion pump the first port being different than a second port of the infusion pump.
  • the shroud of the cartridge connector comprises one or more of a snap arm (e.g., configured to engage the cap of a first medicament cartridge), a detent, and/or a lug.
  • a snap arm e.g., configured to engage the cap of a first medicament cartridge
  • the detent, and/or the lug of the first cartridge connector is different than a snap arm, a detent, and/or a lug of a second cartridge connector.
  • Several embodiments pertain to a medicament connector set for delivering a single or multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features.
  • the medicament connector set comprises the cartridge connector as disclosed above or elsewhere herein as a first cartridge connector and the fluid conduit of the infusion set. In several embodiments, the connector set comprises a first infusion connector in fluidic communication with the first fluid conduit. [0023] Several embodiments pertain to a medicament connector set for delivering a single or multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the medicament connector set comprises the cartridge connector as disclosed above or elsewhere herein as a first cartridge connector. In several embodiments, the medicament connector set comprises a first cartridge connector and a second cartridge connector configured to engage a second medicament cartridge.
  • the second medicament cartridge connector comprises a body comprising a needle, a lower surface portion extending circumferentially from the needle, and a shroud extending axially away from the lower surface portion and configured to receive and fit over a portion of a second medicament cartridge that is configured to hold a second medicament.
  • the needle extends axially within the shroud away from the lower surface portion.
  • the second medicament cartridge connector comprises a knob connected to the body.
  • the knob of the second medicament cartridge connector comprises a lower side extending circumferentially from the shroud of the body, the knob comprising a fluid outlet configured to deliver the second medicament to a position outside the cartridge connector.
  • the knob of the first medicament cartridge connector comprises a lower side extending circumferentially from the shroud of the body of the first medicament cartridge connector, the knob comprising a fluid outlet configured to deliver the first medicament to a position outside the first cartridge connector.
  • the second cartridge connector is configured to engage a second port of the infusion pump the second port being different than the first port of the infusion pump.
  • the shroud of the second cartridge connector comprises one or more of a snap arm configured to engage the cap of the second medicament cartridge, a detent, and/or a lug.
  • one or more of the snap arm, the detent, and/or the lug of the first cartridge connector is different than the snap arm, the detent, and/or the lug of the second cartridge connector.
  • the first cartridge connector is configured to not engage the second medicament cartridge and/or wherein the second cartridge connector is configured to not engage the first medicament cartridge.
  • the first cartridge connector is configured to not engage the second port of the infusion pump and/or wherein the second cartridge connector is configured to not engage the first port of the infusion pump.
  • an infusion system comprising the connector (e.g., a cartridge connector, an infusion connector, or both) disclosed above or elsewhere herein and the infusion site base disclosed above or elsewhere herein.
  • the connector e.g., a cartridge connector, an infusion connector, or both
  • the infusion site base disclosed above or elsewhere herein.
  • a connector set for delivering a single or multiple medicaments to a patient, the medicament connector set comprising the cartridge connector disclosed above or elsewhere herein as a first cartridge connector and a first fluid conduit configured to receive the first medicament from the first cartridge connector.
  • the connector set further comprises a first infusion connector in fluidic communication with the first fluid conduit.
  • the first reservoir connector is the connector as disclosed above or elsewhere herein.
  • a medicament connector set for delivering multiple medicaments to a patient, the medicament connector set comprising the first cartridge connector and the second cartridge connector disclosed above or elsewhere herein.
  • the connector set further comprises a first and second infusion connectors in fluidic communication with the first and second cartridge connectors via first and second fluid conduits, respectively.
  • a system comprising one or more of a cartridge connector (or cartridge connector set), an infusion connector (or infusion connector set), a infusion base, a lumen assembly (or multi-channel lumen assembly), a pump, or any combination of any of the foregoing.
  • Figure 1A illustrates perspective view of an embodiment of an infusion pump engaged to a cartridge connector set and fluid channels showing the upper surface and the bottom side surface of the pump.
  • Figure 1B is a second perspective view of the embodiment Figure 1A, this time showing the upper surface and the top side surface of the pump.
  • Figure 1C is another perspective view of the embodiment Figure 1A showing the upper surface and the bottom side surface of the pump device where the connector set has been removed.
  • Figure 1D is another perspective view of the embodiment Figure 1A showing the upper surface and the top side surface of the pump.
  • Figure 1E is another perspective view of the embodiment Figure 1A showing the lower surface and the top side surface of the pump.
  • Figure 1F is another perspective view of the embodiment Figure 1A showing the lower surface and the top side surface of the pump and the cartridge receptacles.
  • Figure 1G is a view of the embodiment Figure 1A showing the cartridge receptacles of the pump.
  • Figure 1H is another view of the embodiment Figure 1A showing the cartridge receptacles of the pump.
  • Figure 1I is another view of the embodiment Figure 1A showing the cartridge receptacles of the pump.
  • Figure 1J is a view of the upper side surface of the embodiment Figure 1A showing the cartridge receptacles of the pump.
  • Figures 2A-2C show views of the embodiment of Figure 1A with its display screen and/or other portions of the pump face and housing removed, revealing various internal components of the pump.
  • Figure 2A shows a view of the embodiment of Figure 1A with its display screen and pump face removed, revealing various internal components of the pump.
  • Figure 2B shows another view of the embodiment of Figure 1A with its display screen and pump face removed, revealing various internal components of the pump.
  • Figure 2C shows a portion of the cartridge drive assembly of the pump of Figure 1A.
  • Figure 2D shows a view of the embodiment of Figure 1A bisected by a plane through the pump’s height and along the length and width of the pump.
  • Figures 2E and 2F show cross-sectional views of the embodiment of Figure 1A in planes through the pump’s width and along the length and height of the pump, cutting the first cartridge receptacle and the second cartridge receptacle, respectively.
  • Figures 2G and 2H show partially exploded views of the embodiment of Figure 1A with the display and bezel removed. As shown in Figure 2H, the pump comprises a lead screw, a threaded insert, and a drive nut.
  • Figure 2I shows a view of the embodiment of Figure 1A bisected by a plane through the pump’s height and along the length and width of the pump. In this view, a medicament cartridge set and a cartridge connector set are present and/or engaged to the pump.
  • Figure 3A shows a view of the upper side surface of the embodiment of Figure 1A.
  • Figure 4A illustrates a perspective view of another embodiment of a pump, showing the upper surface and top side surface of the pump.
  • Figure 4B shows a view of the embodiment of Figure 4A bisected by a plane through the pump’s height and along the length and width of the pump. In this view, a medicament cartridge set and a cartridge connector set are present and/or engaged to the pump (along with corresponding fluid conduits).
  • Figure 5A shows a view of the top side surface of the embodiment of Figure 1A and Figure 4A, respectively.
  • Figures 6A and 6B are views of a cartridge connector set comprising two cartridge connectors and corresponding fluid conduits (tubing).
  • Figure 6A shows a perspective view of the cartridge connectors (e.g., the connector set).
  • Figure 6B shows a bottom view of the cartridge connectors.
  • Figure 6C illustrates an embodiment of the cartridge connector providing a visual indication of when the connectors from the connector set are unlocked or locked within the pump chamber, respectively.
  • Figure 6D illustrates a cross-sectional view of the connectors of Figure 6A.
  • Figure 6E illustrates a view of the connectors of Figure 6A where the body of one connector has been separated from its knob.
  • Figure 6F-G illustrate different views of one of the connectors of Figure 6A where the body of the connector has been separated from its knob.
  • Figure 6H illustrates a cross-sectional view of one of the connectors of Figure 6A.
  • Figure 6I illustrates an additional cross-sectional view of the connectors of Figure 6A.
  • Figure 6J is a view of another embodiment of a cartridge connector, this one having a fitting as part of its knob.
  • Figure 6K is a different view of the cartridge connector of Figure 6J.
  • Figure 6L is a bisected view of the cartridge connector of Figure 6J.
  • Figures 6M-6T are views of the knob of the cartridge connector of Figure 6J.
  • Figure 6M is a bottom view of the knob.
  • Figure 6N is a top view of the knob.
  • Figure 6O is a first side view of the knob.
  • Figure 6P is a second side view of the knob.
  • Figure 6Q is a perspective view of the knob showing the bottom of the knob.
  • Figure 6R is another perspective view of the knob, this time showing the top of the knob.
  • Figure 6S is an expanded view of a portion of the knob shown in Figure 6T.
  • Figure 6T is a bisected view of the knob.
  • Figure 7A is a view of another embodiment of a cartridge connector set comprising two cartridge connectors.
  • Figure 7B illustrates cross-sectional views of the connectors of Figure 7A.
  • Figures 7C illustrate a bottom view of the connectors of Figure 7A.
  • Figures 7D-E illustrate views of the connectors of Figures 6A and 7A.
  • Figure 7F illustrates a cross-sectional view of an embodiment of a connector set engaged to medicament cartridges.
  • Figures 7G-7H show views of a connector having a check-valve.
  • Figure 7I is a view of another embodiment of a cartridge connector having a fitting and a corresponding mating fitting to which the fitting of the cartridge connector engages.
  • Figure 7J is a view of another embodiment of a cartridge connector having a fitting and a corresponding mating fitting to which the fitting of the cartridge connector engages.
  • Figure 7J includes a similar fitting to that shown for the embodiment of Figure 6K.
  • Figures 8A-8B illustrate cross-sectional views of embodiments of connector sets engaged to medicament cartridges within a pump.
  • Figures 8C-8D illustrate cross-sectional views of embodiments of connector sets engaged to medicament cartridges.
  • Figure 8E illustrates a view of an embodiment of a connector set engaged to medicament cartridges.
  • Figure 9A illustrates an embodiment of a dual lumen portion of a multi- channel lumen assembly.
  • Figures 10A-B illustrate perspective views of a dual infusion set base where 10A also illustrates an insertion implement.
  • Figures 11A-B illustrate perspective views of dual medicament distribution connectors where 11A also illustrates a cover for the distribution connectors.
  • Figures 12A-B illustrate views of a dual medicament infusion set where 12B is a cross-sectional view from the top.
  • Figure 12C illustrates a top view of a portion of another embodiment of an infusion set with the second infusion connector removed from the hub of the infusion base.
  • Figure 12D-12G illustrate the embodiment of Figure 12C with the second infusion connector attached. As shown, the infusion set is configured to infuse multiple medicaments through a single puncture point in the skin (a single site infusion set).
  • Figure 12H illustrates another embodiment of a single puncture site infusion set.
  • Figure 12I illustrates another embodiment of a single puncture site infusion set.
  • Figure 12Ji and 12Jii illustrate another embodiment of a single puncture site infusion set.
  • Figures 12Ki-12Kiii illustrate embodiments of a coaxial delivery conduit with a first and second tubular delivery member.
  • Figure 12Ki shows the coaxial delivery conduit with its first and second tubular members.
  • Figure 12Kii shows the embodiment of Figure 12Ki where medicament is being delivered through the first tubular member.
  • the first tubular member may include lateral apertures through which the medicament may be distributed.
  • Figure 12Kiii shows the embodiment of 12Ki where medicament is being delivered through the second tubular member.
  • Figures 12L illustrates another embodiment of a coaxial delivery conduit with a first and second tubular delivery member.
  • Figures 12M-12O illustrate embodiments of separate infusion bases having tubular delivery members. As shown in Figure 12M, the lateral apertures may be distributed evenly about the delivery member(s). As shown in Figure 12N, the lateral delivery apertures may be located on a portion of a delivery member. As shown in Figure 12O, the lateral delivery apertures may be located on a portion of a delivery member and the delivery members may be of different lengths (e.g., distributing at different depths).
  • Figures 13A-B illustrate a single medicament infusion housing set base where an insertion implement is attached (13A) or detached (13B).
  • Figures 14A-B illustrate perspective views of a single medicament distribution connector where 14A also illustrates a cover for the distribution connector.
  • Figures 15A-B illustrate views of a single medicament infusion base set where 15B is a cross-sectional view from the top.
  • Figures 16A-E illustrate various configurations of dual medicament infusion set bases, connectors, and covers.
  • Figure 16A shows an embodiment of with the right site base, connected to a right site base cover.
  • Figure 16B shows the second site base connected to a second site base cover.
  • Figure 16C shows the first site connector connected to a first site connector cover.
  • Figure 16D shows the second (left) site connector connected to a second (left) site connector cover.
  • Figure 16E shows the dual-medicament infusion site base connected to a dual-medicament site base cover.
  • Figures 17A illustrates a perspective view of a medicament distribution connector (e.g., infusion connector).
  • Figures 18A-E illustrate various configurations of dual medicament infusion set base with distribution connectors. DETAILED DESCRIPTION
  • Some embodiments described herein pertain to medicament infusion systems for one or more medicaments and the components of such systems (e.g., infusion pumps, medicament cartridges, cartridge connectors, lumen assemblies, infusion connectors, infusion sets, etc.). Some embodiments pertain to methods of manufacturing infusion systems and components thereof.
  • Some embodiments pertain to methods for using any of the foregoing systems (e.g., combinations of components) and/or components for infusing one or more medicaments to a patient.
  • Several embodiments disclosed herein ensure proper channeling of medicaments to patients. While multiple recognition features can be used on the various components disclosed herein to reduce any opportunity for mischanneling, no single feature or collection of features is essential or indispensable.
  • some embodiments may include each recognition feature and/or component disclosed herein, while others may not include or may lack one or more features or components disclosed herein while still achieving proper channeling. Any combination of features and/or components is envisioned. As exemplary illustrations, the following combinations are provided.
  • an infusion system may include an infusion pump, but not medicament cartridges.
  • an infusion system may include medicament cartridges and cartridge connectors, but not a pump. In some embodiments, an infusion system may include cartridge connectors and an infusion pump, but not medicament cartridges. In some embodiments, an infusion system may include infusion connectors, a lumen assembly, cartridge connectors, an infusion pump, but not medicament cartridges or an infusion set. In some embodiments, an infusion system may include infusion connectors, a lumen assembly, and cartridge connectors, but not medicament cartridges, an infusion pump, or an infusion base(s). In some embodiments, an infusion system may include infusion connectors, a lumen assembly, cartridge connectors, and an infusion base(s), but not medicament cartridges or an infusion pump.
  • sustained delivery, pump driven medicament injection devices generally include a delivery cannula mounted in a subcutaneous manner through the skin of the patient at an infusion site.
  • a pump draws medicine from a reservoir and delivers it to the patient via the cannula.
  • the injection device may include a channel that transmits a medicament, receiving it via an inlet port and providing a fluid path to the delivery cannula.
  • the medicament may be transmitted to the patient via the cannula, which delivers the medicament to the subcutaneous tissue layer where the delivery cannula terminates.
  • Infusion devices may be configured to deliver one medicament to a patient or multiple medicaments to a patient.
  • a user may load a medicament in an incorrect pump receptacle, which leads to the mistaken belief that he or she is administering one medicament when they are accidentally supplying a different one.
  • the accidental administration of an incorrect medicament to the patient can have serious and potentially fatal consequences.
  • standard-of-care insulin therapies for regulating blood glucose in diabetic patients may involve subcutaneous infusion of insulin via an insulin pump. If the amount of dosed insulin is excessive, it can lead to hypoglycemia or a situation of impending hypoglycemia. To combat and/or reverse such adverse situations, individuals typically consume additional carbohydrates (e.g. sweet juice or glucose tablets).
  • a counter-regulatory agent combats the effect of the excess regulatory agent dose (e.g., excess insulin) alleviating or substantially preventing adverse effects related to the excess dose.
  • excess regulatory agent dose e.g., excess insulin
  • the results could be catastrophic, potentially leading to death.
  • glucagon a counter- regulatory agent that administers a so-called “rescue dose” of a counter- regulatory agent.
  • cross-channeling is dangerous not only because the wrong medicament can lack the intended therapeutic effect, but also because the wrong medicament could have the opposite of an intended effect (or some other side effect that is unanticipated or undesired).
  • improper channeling not only fails to alleviate the patient’s condition, but could make the patient’s condition worse, or cause a new problem-state for the patient.
  • Improper channeling e.g., mischanneling
  • could cause a negative feedback loop e.g., in an autonomous device that monitors the patient’s state, wherein the control system attempts to adjust the patient’s disease state in one direction, but the delivery of the incorrect medicament exacerbates or causes no effect on the disease state.
  • control system can trigger further doses of the wrong medicament in an attempt to control the patient’s condition, while actually causing the patient’s condition to further deteriorate (or causing overdosing of the incorrect medicament).
  • the control system can trigger further doses of the wrong medicament in an attempt to control the patient’s condition, while actually causing the patient’s condition to further deteriorate (or causing overdosing of the incorrect medicament).
  • commercial diabetic drug infusion systems may be inadequate to prevent improper dosing, even where the proper medicament is being administered. For example, runaway dosing can occur in some circumstances, or inadequate dosing in others.
  • diabetic drugs e.g., insulin and glucagon
  • improper channeling can have deleterious effects in many multi-medicament regimens because a medicament is not administered to the patient at the necessary time (and/or at a necessary level), or an incorrect medicament is administered at a dangerous level.
  • Mischanneling can be detrimental in other drug combinations that regulate pancreatic enzymes, other combinations of drugs meant to maintain the body’s equilibrium in one direction or the other, or simply where a patient requires multiple drugs regardless of any relationship between the drugs or a common disease state (e.g., where one drug treats one disease state and another a completely unrelated disease state).
  • cross-channeling can refer to systems with two medicaments
  • cross-channeling as used herein can also refer to systems where more than two medicaments are used and/or where a single medicament is used (for example, when a single medicament is improperly placed in a distribution system).
  • Some embodiments disclosed herein address one or more of problems associated with these problems (e.g., mischanneling, runaway or inadequate dosing, etc.) or others.
  • Described herein are infusion systems for single or multiple medicaments and various connectors, tubes, cartridges, pumps, infusion sets, and/or systems comprising any one or more of the foregoing that ensure, help ensure, and/or substantially aid in providing proper channeling and/or dosing of each medicament to the patient.
  • Certain embodiments of the infusion systems and components thereof described herein are configured to prevent, minimize, lessen, and/or otherwise help avoid the occurrence of cross-channeling and/or improper dosing of medicaments.
  • components comprising recognition features as described herein are configured to impede, prevent, minimize the occurrence of, or otherwise inhibit any opportunity for a user to inadvertently place a medicament in the incorrect position and/or deliver an incorrect medicament (and/or an improper amount of a correct medicament).
  • Cross-channeling may be avoided by providing recognition features (e.g., unique differentiating recognition elements) that allow mating between only particularly shaped components within an infusion system.
  • the infusion system comprises an infusion pump with one, two, or more infusion chambers (or pump chambers) and one or more recognition features.
  • the system further comprises cartridges filled with different medicaments, and connectors and tubing having recognition features that connect to the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments.
  • each type of cartridge for each type of medicament has one or more unique differentiating features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge).
  • Recognition features can comprise, for example geometric or shape-based features, that allow for unique coupling between components of the system. These features may be protrusions (e.g., solid items that take up space) or protrusion-receiving spaces (e.g., apertures or other spaces that may be shaped receive protrusions).
  • a type of connector that has unique differentiating features can engage corresponding (e.g., mating, paired, and/or matched) features in the pump housing and allow for insertion of a proper cartridge into the proper infusion chamber.
  • a cartridge with unique features can interact with a pump infusion pump having corresponding features (e.g., a drive shaft or pump chamber with corresponding features). Improper dosing can be avoided with certain design features disclosed herein, including seals, valves, and other implements incorporated into the components disclosed herein.
  • the system comprises one or more of the following: an infusion pump (configured to receive one or more medicament cartridges in one or more cartridge receptacles), one or more cartridge connectors (configured to engage one or more medicament cartridges), one or more medicament cartridges, an infusion base (configured to deliver the medicament to the patient via a piercing element that may comprise a cannula or needle penetrating the skin of the patient), one or more infusion connectors configured to engage with the infusion base, and a fluid conduit in fluid communication with the one or more cartridge connectors and/or the one or more infusion connectors.
  • the infusion system (or components thereof) include one or more design features that make it compact.
  • the infusion system (or components thereof) are especially suitable to be ambulatory and/or wearable on a patient, allowing the patient freedom of movement (e.g., day-to-day activities, including but not limited to, work, engaging in exercise, swimming, air travel, etc.).
  • the infusion system may be adapted to receive multiple medicaments from multiple medicament cartridges.
  • the system may comprise multiple different configurations of components, including or lacking one or more components selected from two medicament cartridges, an infusion pump configured to receive the two cartridges (e.g., in different cartridge receptacles), cartridge connectors configured to engage the medicament cartridges and/or the infusion pump (e.g., at or near the cartridge receptacles), an infusion set configured to deliver the medicaments to the patient (e.g., a piercing element for the first medicament and a piercing element for the second medicament), two infusion connectors configured to engage with the infusion set, and fluid conduits, each in fluid communication with one cartridge connector and one infusion connector (e.g., providing separate flow paths).
  • an infusion pump configured to receive the two cartridges (e.g., in different cartridge receptacles)
  • cartridge connectors configured to engage the medicament cartridges and/or the infusion pump (e.g., at or near the cartridge receptacles)
  • an infusion set configured to deliver the medicaments to the patient
  • FIG. 1A A two-medicament infusion system is shown in Figure 1A, where the system comprises two different cartridge connectors with corresponding fluid conduits and a pump. Additionally, where the system is configured to delivery three or more medicaments, additional cartridges, cartridge receptacles, cartridge connectors, infusion connectors, and piercing elements may be provided as needed (though the system may also lack any one or more of these components). As disclosed elsewhere herein, while two or more medicaments may be delivered by the infusion system, several embodiments pertain to pumps that deliver a single medicament (e.g., having a pump with only one cartridge receptacle or multiple cartridge receptacles configured to receive a single type of medicament cartridge, for example, insulin).
  • a single medicament e.g., having a pump with only one cartridge receptacle or multiple cartridge receptacles configured to receive a single type of medicament cartridge, for example, insulin).
  • the system and/or components thereof include unique mating features and design elements (recognition features). These recognition features may ensure that each portion of the system can only be connected within the system in a unique way or configuration (e.g., a proper way), thus preventing cross-channeling (e.g., mischanneling).
  • recognition features may ensure that each portion of the system can only be connected within the system in a unique way or configuration (e.g., a proper way), thus preventing cross-channeling (e.g., mischanneling).
  • the medicaments may be kept completely separate throughout their residency within the system (or components thereof) and may have different fluid paths to a patient.
  • cartridge connectors and fluid conduits may be used to provide separate fluid pathways that terminate at designated delivery members (e.g., needles, cannulas, etc.) within a base (e.g., the infusion set), thereby enabling independent delivery (e.g., subcutaneous or otherwise) of medicaments separately.
  • designated delivery members e.g., needles, cannulas, etc.
  • a base e.g., the infusion set
  • design features of the disclosed system give rise to the following advantages or others: (1) allowing the user to easily connect and disconnect the components independently from any medicament sources as well as from the infusion ports or sites; (2) mitigating the possibility of mischanneling that occurs when a user accidentally connects the wrong components together; (3) mitigating possibility for improper dosing levels; (4) mitigating loss of and or contamination of medicaments; (5) allowing for a single or multistep insertion of the dual-cannula infusion site or port.
  • the system and components described herein can further comprise visual or brail call-outs in addition to or instead of various paired physical features disclosed herein.
  • the components can comprise call- outs with wording indicating a proper medicament.
  • different colors red, blue, yellow, green, orange, violet, etc.
  • lengths or other variables to provide visual feedback regarding appropriate medicaments for appropriate components.
  • the infusion system can be used to provide separate fluid pathways for a variety of medicaments (e.g., drugs, hormones, proteins, pharmaceuticals, biologics, etc.) dissolved in a variety of liquid carriers (and/or liquid drugs).
  • different liquid vehicles may be preferred based on the solubility, stability, or sensitivity of the medicament in a particular carrier.
  • aqueous solutions are used as a delivery vehicle for the medicament.
  • solvents such as DMSO are used to dissolve medicaments.
  • solvent/aqueous mixtures are used.
  • a dual medicament system configured to receive insulin and glucagon cartridges.
  • the system may comprise a pump with multiple cartridge receptacles (e.g., chambers) that are configured to receive medicament cartridges containing an identical medicament (and not a different medicament) and/or configured to interact with multiple identical cartridge connectors.
  • the infusion pump may have two medicament receptacles that are identical and that include identical recognition features.
  • receptacles may both be configured to receive identical medicament cartridges and/or may be configured to engage cartridge connectors that are the same (e.g., two cartridges contain insulin and/or two cartridge connectors that are both configured to engage insulin cartridges).
  • the system and its components e.g., the medicament cartridges, infusion pump, cartridge connectors, infusion set, infusion connectors, and a fluid conduit
  • the medicament cartridges, infusion pump, cartridge connectors, infusion set, infusion connectors, and a fluid conduit are configured to receive two (or more) medicament cartridges comprising a particular medicament (e.g., insulin) and not a medicament cartridge comprising a different medicament (e.g., glucagon).
  • an expended single cartridge e.g., one that is empty or close to empty
  • the pump is configured to receive a single medicament cartridge and the system comprises single components to allow the delivery of the same (e.g., a single cartridge connector, a single channel lumen assembly (that may comprise the cartridge connector), a single infusion connector, a single infusion base, a single medicament cartridge, etc.).
  • a single cartridge connector e.g., a single cartridge connector, a single channel lumen assembly (that may comprise the cartridge connector), a single infusion connector, a single infusion base, a single medicament cartridge, etc.
  • each of these components may be taken individually and/or apart from the system (e.g., as a standalone infusion pump, cartridge connector, medicament cartridge, infusion set, infusion connector, multi-channel lumen assembly, and fluid conduit).
  • a component may be part of an infusion system (that may include any combination of components), as disclosed herein.
  • any combination of recognition features within the infusion system can be mixed and matched to address the mischanneling problem just as any dosing safety features may be mixed and matched to address improper administration issues.
  • a cartridge connector may be uniquely shaped in a way that allows it to only engage with one medicament vial (and not others) and uniquely threaded so that it only engages a corresponding cartridge receptacle in a pump.
  • such features may be sufficient to avoid mischanneling and other features need not be included.
  • the cartridge receptacle of the pump may lack a recognition feature configured prevent insertion of a cartridge and instead the connector is configured to engage a particular medicament cartridge and a particular cartridge port in the pump.
  • an infusion pump as disclosed herein is a part of and/or a component of an ambulatory infusion system.
  • the pump may include a face P1002 (e.g., a front), a backing P1003 (e.g., a back), a bottom side P1005 (e.g., a lower side surface), a top side P1004 (e.g., an upper side surface), a first side surface P1006' (e.g., a right side surface), and a second side surface P1006'' (a left side surface).
  • the pump face P1002 and pump backing P1003 may each extend (e.g., laterally as a plane) along the upper side surface P1004 and lower side surface P1005 of the pump P1000 providing a pump width P(w).
  • the pump face P1002 and pump backing P1003 may each extend (e.g., longitudinally as a plane) between the lower side surface P1005 and upper side surface P1004 in a direction along the first side surface P1006' and second side surface P1006'' of the pump P1000, providing a pump length P(l).
  • the pump P1000 may also have a height P(h) extending between the pump face P1002 and the pump backing P1003 in a direction along the first side surface P1006' (and/or along the second side surface P1006'').
  • the face P1002, backing P1003, lower side surface P1005, upper side surface P1004, first side surface P1006', and second side surface P1006'' of the pump provide an outer perimeter of the pump.
  • the infusion pump P1000 includes a pump housing P1001 that encases and/or houses one or more internal components of the infusion pump.
  • the pump housing P1001 can comprise a bezel P1001' and a lower portion P1001''.
  • the lower portion P1001'' provides a frame onto which the bezel fits and/or connects.
  • a portion of the lower portion P1001'' may extend to the pump face P1002.
  • the lower portion P1001'' and/or the frame of the lower portion extends to the face of the pump to provides the upper side surface P1004 of the pump P1000.
  • the upper and lower portions of the housing may be sonically welded together, snap fit, glued or otherwise affixed to one another.
  • the upper and lower portions of the housing may be different materials or the same.
  • the lower portion is a metal and the upper portion is not.
  • the upper portion is polymeric and/or plastic, and the lower portion is not.
  • both the lower portion and the upper portion are independently a polymeric material (e.g., a plastic) or a metal.
  • a generally rectangular prism shaped configuration of the pump P1000 (as shown) has been found to advantageously accommodate internal pump components in a compact way (e.g., suitable for wearing).
  • the compact nature of the rectangular prism configuration reduce bulk and increase the ease with which the disclosed infusion system can be worn and/or used.
  • the compact nature of the design increases user compliance and convenience. While a rectangular prism provides certain advantages with regard to the configuration of the internal components of the pump, in other embodiments, other shapes may be adopted (e.g., generally cube-shaped, oblong, cylindrical, oval cylindrical, etc.).
  • the housing of the pump P1001 has rounded edges to improve shock absorption and/or resistance to cracking when impacted (e.g., by dropping, etc.).
  • the pump P1000 comprises a display region P1007.
  • the display region P1007 is a display screen and/or a touch screen.
  • the display region P1007 may be configured to provide the user with data (e.g., alphanumeric, image- based, etc.) regarding medicament levels, drug dosing rates, information about blood sugar levels, and/or other diagnostic information.
  • the display screen allows the user to adjust the distribution of medicaments or other pump and delivery settings (including one or more control features disclosed herein).
  • the bezel provides support for and/or engages the display screen, holding it in place.
  • the lower side surface P1005 of the pump P1000 may comprise a touch pad P1010.
  • the touch pad P1010 is a finger pad having a curved indentation configured to receive a finger of a user.
  • a capacitive touch sensor may be located under the finger pad P1010 and/or is in electronic communication with the finger pad P1010.
  • additional capacitive touch sensors may be in communication with different surfaces of the pump (e.g., elsewhere on the pump face, pump backing, the upper side surface, the first side surface, or the second side surface).
  • the display P1007 may be a capacitive touch sensor and/or a capacitive touch sensor may be located at or behind a portion of the pump face P1002 (e.g., making the display a touchscreen).
  • a capacitive touch sensor of the display P1007 may be activated by touching the display P1007 in designated locations and/or by touching the separate finger pad P1010 (and/or a different the surface) of the pump P1000.
  • the capacitive touch sensor of the display P1007 may be used to control and/or send signals to components within the pump P1000, for example, allowing a user to control one or more aspects of the drug delivered from the reservoirs located within the pump.
  • FIGS 1A and 1B show a multiple medicament pump P1000 engaged to two cartridge connectors C1001, C1101 (e.g., a first and a second cartridge connector). These cartridge connectors can be configured to attach to different medicament cartridges and to simultaneously engage the pump via cartridge receptacles (e.g., first and second cartridge receptacles).
  • a first and second fluid conduit T1001, T1101 are engaged to the first and second cartridge connectors C1001, C1101, respectively.
  • medicament cartridges may be housed in chambers that are engaged with the cartridge connectors C1001, C1101.
  • tubing a first tube and a second tube that is configured to provide a fluid path to the infusion set and/or infusion connectors (not shown).
  • the pump 1000 comprises cartridge receptacles P1100, P1110 (e.g., cartridge holders, cartridge chambers, and/or cartridge repositories).
  • the cartridge receptacles include medicament receptacle inlet ports P1100', P1110'.
  • the cartridge connectors C1001, C1101 shown in Figures 1A and 1B (and corresponding medicament cartridges M1001, M1101, visible in Figure 2I) have been disengaged and removed from the pump P1000, making the cartridge receptacles P1100, P1110 and inlet ports P1100', P1110'' visible.
  • these cartridge receptacles are configured to house (e.g., receive, secure in place, hold, etc.) the medicament cartridges M1001, M1101 (as shown in Figure 2I).
  • the pump P1000 may comprise a first medicament chamber P1100 that is different from a second medicament chamber P1110.
  • one or more design features e.g., recognition features
  • the inlet ports P1100', P1110' and/or other features within the cartridge receptacles P1100, P1110 prevent proper engagement of the cartridge connectors and/or prevent insertion of an improper cartridges into an incorrect chamber.
  • these chambers P1100, P1110 or inlet ports P1100', P1110' may include one or more recognition features P1101, P1102, P1103, P1111, P1112, P1113 that prevent or inhibit coupling to improper components.
  • the cartridge receptacles are configured to receive particular medicament vials and not others. For instance, a given receptacle can be configured to not receive an incorrect medicament cartridge (e.g., by virtue of the diameter, length, size, or shape of the medicament cartridge). In other embodiments, the cartridge receptacles may be configured to receive different types of cartridges indiscriminately.
  • a first cartridge connector C1001 may be configured to engage only a specific medicament cartridge M1001 (e.g., a first medicament cartridge) and a second cartridge connector C1101 may be configured to engage only a corresponding specific medicament cartridge M1101 (e.g., a second medicament cartridge).
  • the inlet ports P1100', P1110' may include unique mating features (e.g., recognition features) that allow them only to engage a specific medicament cartridge connector with corresponding mating features.
  • the first receptacle may be configured to engage the first cartridge connector and not the second cartridge connector.
  • the second receptacle may be configured to engage the second cartridge connector and not the first cartridge connector.
  • a given receptacle can be configured to not receive an incorrect medicament cartridge (e.g., by virtue of the shape of the medicament cartridge) and to also not engage an incorrect cartridge connector.
  • the pump is configured to receive a medicament cartridge that is already connected to a connector.
  • a medicament cartridge may be connected to a cartridge connector, then the pump can receive the cartridge and connector simultaneously (only allowing engaging of an appropriate connector and/or cartridge).
  • the pump may receive the medicament cartridge (e.g., loosely, without and/or free from the cartridge connector). Then, the pump may be configured to receive the cartridge connector into the cartridge receptacle over the cartridge, where the connector can be locked in position (e.g., twisted into place) within the pump.
  • the connector may be configured to simultaneously engage both the vial and the pump.
  • the connector or medicament cartridge are improper for a given receptacle, certain recognition features can prevent engagement of the connector. For instance, where the cartridge and connector are not paired, the cartridge be of insufficient diameter to receive the cartridge, preventing the engagement of the cartridge connector to it and holding the cartridge connector in a position that is too far from the pump to engage the inlet port. Alternatively, the connector may receive the incorrect vial, but may travel too deep within the receptacle to engage the inlet recognition features of the pump. [0116] As shown in Figure 2I, the inlet port P1100' of the first medicament chamber P1100 may be configured to engage a first cartridge connector C1001 and/or receive a first cartridge M1001.
  • the inlet port P1110'' of the second medicament chamber P1110 is configured to engage a second cartridge connector C1101 and/or receive a second cartridge M1101.
  • the inlet port P1100' of the first medicament chamber P1100 is configured not to engage a cartridge connector that engages the second inlet port P1110'' (e.g., the second cartridge connector C1101).
  • the inlet port P1110'' of the second medicament chamber P1110 is configured not to engage a cartridge connector that engages the first inlet port P1100' (the first cartridge connector C1001).
  • the first receptacle P1100 is configured to house or receive a cartridge and cartridge connector for a regulatory agent (e.g., insulin) and the second medicament chamber P1110 is configured to house or receive a cartridge and cartridge connector for a counterregulatory agent (e.g., glucagon).
  • a regulatory agent e.g., insulin
  • a counterregulatory agent e.g., glucagon
  • each of the pump chambers P1100, P1110 comprises one or more recognition features P1101, P1102, P1103, P1111, P1112, P1113 configured to prevent or inhibit mischannelling.
  • the features may be protrusion- shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of a cartridge connector corresponding to the pump chamber.
  • protruding features e.g., protrusions, tabs, lugs, detents
  • radial divots e.g., divots or notches shaped to receive corresponding and/or mated protruding features
  • protrusions e.g., tabs, lugs, detents
  • a mixture of protrusions and divots may be provided on or within the inlet ports to prevent or inhibit mischannelling (not shown).
  • corresponding radial divots and/or protrusions may be provided on a corresponding cartridge connector.
  • the features of the pump receptacles P1100, P1110 may be located at a position proximal to the entrance of the receptacle (e.g., at the inlet ports P1100', P1110') to allow interaction with a corresponding cartridge connector.
  • cartridge connectors C1001, C1101 corresponding to the pump receptacles P1100, P1110 respectively, comprise corresponding protrusions (e.g., tabs, lugs, detents).
  • these protrusions include lugs C1010, C1011, C1110, C1111 and/or detents C1012, C1112.
  • each cartridge chamber may have a plurality of recognition features configured to mate with corresponding recognition features of the cartridge connectors.
  • each pump chamber P1100, P1110 comprises three radial carve-outs configured to engage correspondingly shaped lugs and detents of corresponding cartridge connectors C1001, C1101, respectively, shown in Figure 6B.
  • each inlet port 1100', 1110' has three radial divots as recognition features
  • each pump chamber can independently have one, two, three, four five, or more recognition features (e.g., divots and/or protrusions) configured to receive corresponding recognitions features (e.g., protrusions and/or divots) from corresponding cartridge connectors.
  • cartridge receptacles have been described as comprising divots and the cartridge connectors as comprising protrusions, the opposite configuration is also possible (where divots are on the cartridge connectors and protrusions on the receptacles).
  • types of recognition features could be mixed and matched on a particular receptacle or cartridge connector (so the receptacle comprises both protrusions and divots and the corresponding cartridge connector has corresponding divots and protrusions).
  • a cartridge receptacle can comprise only divots and a different cartridge receptacle in the same pump can comprise only protrusions.
  • the corresponding cartridge connector set can comprise a connector with corresponding protrusions and a connector with corresponding divots, respectively.
  • a first cartridge connector comprises five protruding features (e.g., three lugs and two detents; not shown)
  • a corresponding first receptacle e.g., a first inlet port
  • a second cartridge connector could comprise four divots (e.g., two lug openings and two detent openings) configured to engage a corresponding second receptacle comprising four protrusions (e.g., two lugs and two detents) to be received within those divots.
  • the lug openings and detent openings may be various different sizes (e.g., circumferential lengths, radial heights, etc.).
  • a lug opening of one cartridge receptacle may be of one length lug(l'), a second may be of a second length lug(l''), these lengths may be different from each other and/or from the lug lengths of a second cartridge receptacle lug(l'''), lug(l''').
  • a detent opening of one cartridge receptacle may be of one length det(l') that is different from a detent opening length det(l'') of the other cartridge receptacle.
  • these openings are configured to receive correspondingly sized lugs and detents (e.g., of corresponding lengths) located on corresponding cartridge connectors (as shown in, for example, Figure 6B).
  • the detent and lug openings of two different medicament receptacles P1100, P1110 may have corresponding positions.
  • the detent openings P1103, P1113 for both inlets P1100', P1110'' are located at 12 o’clock positions of the receptacles P1100, P1110, the first lug openings P1101, P1111 are at 9 o’clock, and the second lug openings P1102, P1112 are at 3 o’clock.
  • the lugs and detents are not in corresponding positions or only a portion of the lugs and detents are in corresponding positions. In some embodiments, even where lug openings and detent openings are in corresponding positions on separate inlets (or separate connectors), the attachment of an incorrect cartridge connector can be prevented and/or substantially hindered by providing different sizes of those equivalently positioned features.
  • a feature on a first receptacle e.g., a lug opening, a detent opening, a lug, a detent, etc.
  • a size difference of at least 15% (e.g., is 15% larger or smaller) than an equivalent feature on a second receptacle (e.g., a feature that is in the same relative position)
  • mischanneling can be prevented and/or substantially inhibited.
  • the ratio of the length of a feature of one receptacle as compared to the length of an equivalent feature on a different receptacle is equal to or at least about: 3:1, 5:2, 2:1, 5:3, 4:3, 20:17, or ranges spanning and/or including the aforementioned ratios.
  • one or more recognition features e.g., lugs, detents, openings configured to receive lugs or detents, etc.
  • the mid-point of one recognition feature may be positioned at the 9 o’clock position and an adjacent recognition feature may have a midpoint at 12 o’clock, thereby being separated by 90°.
  • adjacent recognition features of the inlets P1100', P1110' or connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise.
  • non-adjacent recognition features of the inlets P1100', P1110' or connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise.
  • any dimension of that divot, position of that divot, or relationship of that divot to another divot (e.g., a second divot) described herein also applies to protrusions or to relationships between protrusions. For brevity, such relationships have been shortened or omitted, as they will be readily appreciated in view of the disclosure.
  • any recognition feature e.g., notch, protrusion, etc. described with respect to a cartridge receptacle applies to recognition features of cartridge connectors.
  • divots may open to tracks P1101', P1103', P1111', P1113' (e.g., slots, paths, etc.). In some embodiments, these paths travel and/or are positioned circumferentially within the medicament receptacles P1100, P1110.
  • the connector is rotated to lock the cartridge connector into the receptacle. For example, in the embodiment shown in Figures 1A-1J, the connectors may each be rotated a quarter turn to lock them each into place within the pump chambers.
  • a lug of the cartridge connector in initially inserted though the lug opening P1101 and then is rotated a quarter turn to a position it under the other detent opening P1102 of the pump chamber P1100.
  • the lug travels along the lug path to its locked position.
  • a larger lug can be positioned under the opening for a smaller lug.
  • alignment of the lug under the smaller detent or smaller lug opening inhibits removal of the cartridge connector from the pump chamber once locked since the larger lug cannot pass through the smaller detent or lug opening.
  • the receptacle inlet comprises protrusions (not shown)
  • corresponding divots and tracks are located on a corresponding cartridge connector.
  • the cartridge connectors may be configured to require a clockwise turn to lock one cartridge connector (and cartridge) in place in its corresponding receptacle and a counterclockwise turn to lock the other cartridge connector (and cartridge) in place in its corresponding receptacle.
  • the direction of twisting is another optional indicator that allows a user to avoid mischanneling.
  • the cartridge connectors and cartridge receptacles may be configured to both allow clockwise turning to lock the cartridges in place.
  • the cartridge connectors and cartridge receptacles may be configured to both allow counterclockwise turning to lock the cartridges in place.
  • the cartridge receptacles P1100, P1110 may include a first “shallow” detent cam P1103', P1113' that comprises a smaller transition angle than a second “step” detent cam P1103'', P1113'' that comprises a larger transition angle.
  • the cartridge connector as the cartridge connector (and corresponding detent lug) is inserted into the opening of the corresponding pump chamber, the cartridge connector is rotated in a first direction to lock the connector into the pump chamber.
  • the detent may abut against and then travel over the first “shallow” detent cam until the detent reaches a transition P1103''', P1113'''. As rotation continues, the detent travels over the transition P1103''', P1113''' and passed the second steep detent cam P1103'', P1113'' reaching a detent clearance configured to receive the detent. At the same time, the lugs reach the end of their tracks, stopping or impeding further twisting of the cartridge connector.
  • the detent clearance may be bordered on one side by the second “steep” detent cam P1103'', P1113'', which would require a greater rotating force in an opposite direction to permit the detent to overcome the second cam and to remove the detent from the clearance.
  • the combination of the different detent cams causes cartridge connector to require a greater amount of force to remove and/or unlock the cartridge connector from the pump chamber once it is locked into the pump than the initial amount of force that is required to lock the cartridge connector to the pump chamber.
  • the ratio of the angle of a steep cam as compared to angle of the shallow cam is equal to or at least about: 5:1, 3:1, 5:2, 2:1, 5:3, 4:3, or ranges spanning and/or including the aforementioned ratios.
  • the steep and shallow cam can be configured to lock lugs in position (instead of or in addition to the detents).
  • the receptacle inlet comprises protrusions (not shown)
  • corresponding cams and tracks are located on a corresponding cartridge connector.
  • the receptacles P1100, P1110 may comprise one or more snap-arm clearance recesses P1105a, P1105b, P1115a, P1115b (e.g., snap-arm extension recesses).
  • the snap-arm clearance recesses extend down (e.g., axially) a portion of one or more of the medicament receptacles.
  • these recesses are configured to allow and/or to provide space for the expansion of snap arms C1105a, C1105b, C1115a, C1115b (shown in Figure 6D) on cartridge connectors C1001, C1101 to engage medicament cartridges that reside in the cartridge receptacles P1100, P1110.
  • snap arms C1105a, C1105b, C1115a, C1115b shown in Figure 6D
  • cartridge connectors can then be inserted into the receptacles.
  • the snap arms expand as the snap arm passes over the periphery of the medicament cartridge cap.
  • the snap arm recess allows this expansion for an appropriately placed connector and/or cartridge.
  • lip e.g., tooth, edge, steps, or other cap locking mechanism
  • the snap-arms are unable to expand over the cap of the cartridge, preventing and/or hindering the connection of an inappropriate medicament.
  • the receptacles themselves may be different shapes or sizes such that they accept one type of medicament cartridge, but not another.
  • the chambers may have different diameters, shapes, or lengths such that one medicament may be received and or engaged, but not another.
  • the chamber diameters may be different.
  • the glucagon chamber may have a lip that transitions it from one diameter to another smaller diameter traveling distally from the inlet.
  • an insulin cartridge may not be insertable into glucagon chamber.
  • the glucagon cartridge (which is smaller diameter) can go into the insulin chamber.
  • a stop rib in the bottom of the chamber prevents full insertion of the glucagon cartridge.
  • the glucagon cartridge may be larger than the insulin chamber to achieve the opposite effect.
  • the glucagon cartridge includes an insertion stop rib.
  • the stop rib prevents the glucagon cartridge from seating low enough to allow the connection within the insulin chamber.
  • the cartridges are the same diameter and other aspects disclosed herein may be implemented to avoid mischanneling.
  • O-rings P1150a, P1150b, P2150a, P2150b are placed within saddles P1132, P1134, P2132, P2134.
  • these O-rings provide a water resistant and/or waterproof barrier between the pump chambers P1100, P1110, P2100, P2110 and the internal area P1008, P2008 of the pump.
  • the saddles are molded within the lower portion of the pump housing P1001'', P2001'' and/or are unitary portions of the lower portion of the housing.
  • the saddles are located at the bottom of the pump chambers P1100, P1110, P2100, P2110 and/or make up a portion of the bottom of the pump chambers.
  • the saddles P1032, P1034, P2032, P2034 provide a circumferentially, inwardly extending bottom of the pump chambers P1100, P1110, P2100, P2110.
  • the saddles P1132, P1134, P2132, P2134 are configured to engage and/or hold the O-rings P1150a, P1150b, P2150a, P2150b in place.
  • the O-rings P1150a, P1150b, P2150a, P2150b are configured to seal against and/or engage two drive nuts P1142, P1144, P2142, P2144 (e.g., piston shafts).
  • a fully retracted drive nut P1142, P1144, P2142, P2144 along with the circumferentially inwardly extending saddles P1132, P1134, P2132, P2134 of the pump provide a distal end of the pump P1000, P2000 against which medicament cartridges abut when placed inside the pump P1000, P2000 (as shown in Figure 2I and 4B).
  • the drive nuts P1142, P1144, P2142, P2144, enter the pump receptacles P1100, P1110, P2100, P2110 via receptacle apertures P1100a, P1110a, P2100a, P2110a.
  • the O-rings engage the drive nuts P1142, P1144, P2142, P2144 to prevent ingress of dirt, grime, water, and/or air into the pump internal area P1008, P2008 from the medicament cartridge receptacles P1100, P1110, P2100, P2110.
  • the seal between the O-rings 1150a, P1150b, P2150a, P2150b and the drive nuts P1142, P1144, P2142, P2144 are airtight and/or watertight. In some embodiments, the seal between the O-rings 1150a, P1150b, P2150a, P2150b and the drive nuts P1142, P1144, P2142, P2144 seal the internal area of the pump from the pump chambers in an airtight and/or watertight manner. [0132] As shown in, for example, Figure 2A, in some embodiments, the motors P1060 rotate and/or move a drive gear P1071 (e.g., a pinion gear) in a gear assembly.
  • a drive gear P1071 e.g., a pinion gear
  • each gear assembly P1070 (of which there are two pictured, a first and a second) comprises four gear components P1071, P1072, P1073, P1074 and facilitates turning of lead screws P1152, P1154 within the internal area of the pump.
  • the gear ratios of laterally adjacent and/or engaged gear wheels in the gear assembly may be equal to or at least about: 3:1, 4:1, 5:1, 8:1, or ratios spanning and/or including the aforementioned ratios.
  • the gear configuration in the assembly from the motor pinion to the drive pinion on the lead screw is 4:1, 5:1, 5:1 (e.g., for a total effective gear ratio of 100:1).
  • radially adjacent and/or stacked gear configurations give the infusion pump a compact design.
  • the total effective gear ratio of the gear assembly is equal to or at least about: 200:1, 100:1, 75:1, 50:1, or ratios spanning and/or including the aforementioned ratios.
  • a gear assembly in the pump may comprise both small gear wheels P1071a, P1072a, P1073a and large gear wheels P1072b, P1073b, P1074b.
  • the gear assembly P1070 comprises one or more stepped gear components P1072, P1073.
  • a stepped gear comprises a larger gear wheel P1072b, P1073b and a smaller gear wheel P1072a, P1073a on the same gear component.
  • the ratio of the diameter of the larger gear wheel and smaller gear wheel of a stepped gear may be equal to or at least about: 3:1, 4:1, 5:1, 8:1, or ratios spanning and/or including the aforementioned ratios.
  • a laterally traversing gear assembly with multiple gear steps advantageously allows the height of the pump to be reduced. Additionally, the motors can be placed laterally adjacent to their drive nut, adding to the compactness of the design. [0134]
  • the diameters of each of the large gear wheels are similar to one another.
  • the diameters of each of the large gear wheels are within about 20% of one another. In some embodiments, the diameters of the large gear wheels differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values.
  • the diameter of the largest gear wheel in the gear assembly and the diameter of the second largest gear wheel in the gear assembly differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values. In some embodiments, the diameter of the largest gear wheel in the gear assembly and the diameter of the third largest gear wheel in the gear assembly (e.g., where there are two gear wheels larger than it in the gear assembly) differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values.
  • the bottom section P1001''b of the lower portion P1001'' of the pump housing P1001 of the embodiment of Figure 1A has a radius of curvature P(r) f corresponding to a circle (shown with the dashed line).
  • the bottom section P1001''b is defined by the section of the pump that is the lower half of the height P(h) of the pump 1000.
  • the bottom section P2001''b of the lower portion P2001'' of the pump housing P2001 of the embodiment of Figure 4A has a multiple radii of curvature P(r) fa , P(r) fb corresponding to an elliptical shape of the pump housing P2001, which is shown with the dashed line. It has been noted that, by including an elliptical shape (as with the embodiment of Figure 4A) around the receptacle inlet port P2100', increased housing strength is achieved. In several embodiments, advantageously, this increased housing strength protects the pump and its components from breakage during an accidental drop (e.g., display shatter or cracking, etc.).
  • the increased housing strength is realized using an elliptical shape characterized by a lower radius of curvature P(r) fb and an upper radius of curvature P(r) fa .
  • increased housing strength is realized where the lower radius of curvature P(r) fb is smaller than the upper radius of curvature P(r) fa .
  • the ratio of the lower radius of curvature P(r) fb to the upper radius of curvature P(r) fa is equal to or at least about: 1:2, 2:3, 4:5, 9:10, or ratios spanning and/or including the aforementioned values.
  • an elliptical configuration adds housing material between the receptacle inlet ports P2100' and a periphery of the pump P2001 (shown by the double headed arrows of Figure 5A).
  • O-Ring and Chambers [0137]
  • Various embodiments include one or more boundary sealing O-rings within the pump housing.
  • the placement of the O-ring seals the medicament chamber(s) from the internal portion of the pump.
  • the O-ring does not seal the cartridge receptacle(s) from the environment external to the pump.
  • an internal area of the cartridge receptacles is able to equalize with any atmospheric pressure outside and/or external to the pump.
  • the area internal to the pump housing is sealed from the atmosphere (e.g., in an airtight and/or watertight manner) to prevent the ingress of harmful contaminants into the pump.
  • Some embodiments have been designed in such a way to allow a drug cartridge to match the atmospheric pressure of the patient line and infusion site.
  • Differences in atmospheric pressures between the infusion site e.g., an area external to the pump
  • those felt at a drug cartridge sealed within an infusion pump can lead to under/over delivery of a medicament.
  • the sealing of the cartridge chamber may occur at an atmospheric pressure eventually ends up being different than the atmosphere pressure of the external environment.
  • a pressure differential may occur.
  • the pressure differential of high chamber pressure and low external pressure may force additional medicament to be distributed from the cartridge as the pressure within the pump attempts to equalize to the external pressure.
  • the cartridge chamber and the medicament cartridges themselves are not necessarily sealed from the environment (and/or are allowed to pressure equilibrate with the external environment) and because the cartridge chamber in the infusion pump may allow air and water to pass freely around the drug cartridges
  • the drug cartridge chamber and drug cartridge may be made airtight and/or watertight (or impervious or substantially impervious to the effects of the environment).
  • the medicament cartridge chamber may be sealed substantially from the ingress of water (e.g., having a sealing mechanism that prevents water from infiltrating the cartridge area), but still, may allow air or gases to move through the seal to equalize the pressure differential between the infusion site and drug cartridge.
  • the seal may be watertight but not airtight. In some embodiments, the seal provides an aperture between the cartridge connector that is sufficiently small so that the surface tension of water prevents its ingress, but does not prevent the ingress (or exiting) of air (or other gases).
  • Cartridge Connectors [0140] As disclosed elsewhere herein, some embodiments, pertain to one or more cartridge connectors and/or a cartridge connector set (comprising cartridge connectors). In some implementations, the cartridge connector(s) (or cartridge connector set) is a part of lumen assembly (e.g., a multi-channel lumen assembly), as disclosed elsewhere herein.
  • a cartridge connector (or a cartridge connector set) is a part of an ambulatory infusion system, as disclosed elsewhere herein.
  • an infusion system comprising the cartridge connector set is provided.
  • the connector set comprises a single cartridge connector.
  • the connector set comprises two, three, four, or more cartridge connectors that may be the same or different.
  • the cartridge connector set includes fluid conduits that are attached to the cartridge connectors.
  • the cartridge connector set further comprises infusion connectors that connect to an infusion set (which includes implements such as needles configured to infuse a subject with a medicament or medicaments).
  • a connector is described as being part of and/or engageable with a multi-channel lumen assembly (having two or more lumens) or a lumen assembly, which may comprise a single channel medicament path.
  • a connector is described in the context of one type of assembly (e.g., multi-channel lumen assembly or a lumen assembly)
  • those features are also applicable to the other type of assembly (e.g., a lumen assembly or a multi-channel lumen assembly).
  • a connector is described in communication and/or connected with a multi-channel assembly, those features may be present in a lumen assembly, and vice versa.
  • the cartridge connector(s) (or cartridge connector set) is part of and/or irreversibly connected to a lumen (e.g., of the multi-channel lumen assembly, of a tail as disclosed elsewhere herein, etc.).
  • a lumen e.g., a fluid conduit
  • the cartridge connector(s) (or cartridge connector set) connects and/or engages a lumen of the multi-channel lumen assembly via a reversibly connectable fitting.
  • the fitting allows reversible connection (e.g., coupling and decoupling), so the connector can be engaged within the multi-channel lumen assembly providing fluidic communication between the connector and a lumen of the multi-channel lumen assembly.
  • Figure 6A shows a cartridge connector set C1000 configured to engage the pump P1000 of Figure 1A.
  • the cartridge connectors C1001, C1101 comprise a body C1002, C1102.
  • the body C1002, C1102 comprises a piercing element C1003, C1103 (e.g., a needle).
  • the piercing element is configured to pierce the septum of a medicament cartridge and/or to receive a medicament from a medicament cartridge (e.g., when the cartridge is inserted into the connector).
  • the cartridge connectors C1001, C1101 comprise a lower surface portion C1004, C1104 extending circumferentially from the needle C1003, C1103 to a skirt C1005, C1105 (e.g., axially extending side wall, shroud, etc.) of the connector.
  • the shroud extends axially away from the lower surface portion.
  • the shroud is configured to receive and fit over a portion of a medicament cartridge.
  • Figure 6J shows an alternative embodiment of a cartridge connector C3001 configured to engage a pump (e.g., the pump P1000 of Figure 1A).
  • the cartridge connector C3001 comprises a body C3002.
  • the body C3002 comprises a piercing element C3003 (e.g., a needle).
  • the piercing element C3003 is configured to pierce the septum of a medicament cartridge and/or to receive a medicament from a medicament cartridge (e.g., when the cartridge is inserted into the connector).
  • this connector C3001 of Figure 6J is shown without a second connector (which would provide a connector set), in several embodiments, this connector C3001 could be a part of a connector set (not shown).
  • a connector C1001, C1101, C2001, C2101, C3001 can be mixed and matched with any other connector C1001, C1101, C2001, C2101, C3001, which may have one or more differing or common recognition features (as disclosed elsewhere herein) to avoid mischanneling.
  • the connector C3001 comprises a lower surface portion C3004 extending circumferentially from the needle C3003 to a skirt C3005 (e.g., axially extending side wall, shroud, etc.) of the connector.
  • the shroud extends axially away from the lower surface portion.
  • the shroud is configured to receive and fit over a portion of a medicament cartridge.
  • the lower surface portion C1004, C1104, C3001 is located within the shroud C1005, C1105, C3005 and is configured to contact a cap of the medicament cartridge when the medicament cartridge is inserted into cartridge connector (e.g., within the shroud).
  • the needle C1003, C1103, C3003 extends axially from the lower surface portion C1004, C1104, C3004 within the shroud C1005, C1105, C3005. In some embodiments, the needle does not extend passed the shroud.
  • Figures 6A, 6L, and 7A provide views of a cartridge connector shroud and skirt ring at the bottom of the shroud (e.g., distal from the lower surface portion C1004, C1104, C3004 of the connector).
  • the shroud C1005, C1105, C3005 comprises a distal end that is away from the lower surface portion C1004, C1104, C3004 of the connector C1001, C1101, C3001.
  • the distal end of the shroud C1005a, C1105a, C3005a is unbroken (e.g., lacks any spaces, gaps, is a ring) and extends circumferentially around an axis of the connector C1001A, C1101A (shown in Figure 6A).
  • the shroud forms an uninterrupted ring around the bottom of the cartridge connector.
  • the needle is recessed within the connector above the shroud.
  • the unbroken end of the shroud aids in proper placement of a medicament cartridge into the connector C1001, C1101, C3001.
  • a cartridge could be inserted into the connector at an angle more easily (by expanding the shroud). If inserted at an angle and with the medicament cartridge not travelling along the axis of the cartridge connector, the piercing element of the cartridge could pierce the septum at a location that is off-center. Then, as the cartridge is inserted to a point where it abuts the lower surface C1004, C1104, C3004 the cap of the vial would become flush to the lower surface C1004, C1104, C3004 tearing and/or forming a gap at the septum where medicament could egress.
  • a connector C1001, C1101, C3001 can comprise a bowl shape or a concavity C1004a, C1104a, C3004a on or within the lower surface C1004, C1104, C3004.
  • the concavity C1004a, C1104a, C3004a may provide a portion of the lower surface C1004, C1104, C3004 and the remainder of the lower surface C1004, C1104, C3004 may include a lip C1004b, C1104b, C3104b (e.g., configured to contact and/or abut the cap of an appropriate medicament cartridge).
  • this bowl feature puts distances the inflection point and/or the flex point of the needle from the septum.
  • the connector C1001, C1101, C3001 comprises a knob C1006, C1106, C3006.
  • the knob can be of irregular shape (e.g., partially oval with a flat portion, etc.).
  • the knob comprises an upper knob portion C1006a, C1106a, C3006a that extends distally from the upper side surface portion C1006b, C1006b, C3006a of the knob C1006, C1106, C3006 at a position that is offset from a geometric center C1006b, C1006b, C3006b of the surface portion of the of the knob such that the upper knob portion closer to one side of the perimeter of the surface portion than another side.
  • the perimeter of the surface portion C1006b, C1006b, C3006b comprises a flattened portion.
  • a portion of the knob when inserted into the pump P1000, a portion of the knob (e.g., a portion of the surface portion C1006b, C1006b, C3006b) hangs over the pump to provide a lip that gives tactile feedback that the knob is not correctly positioned and/or is not fully engaged.
  • the knob of the cartridge connector when twisted a quarter turn to engage the pump, the knob of the cartridge connector then aligns so that the lip is no longer present and the knob is in alignment with the pump (as shown in Figure 1A).
  • the knob C1006, C1106, C3006 is in the shape of a cam and having a flattened portion C1006'a, C1106'a, C3006'a.
  • the knob C1006, C1106, C3006 comprises a rib portion C1006'', C1106'', C3106'' (e.g., a ridge, a finger hold, wing, etc.).
  • the rib provides a handle making the cap more easily manipulated between the fingers.
  • the knob C3006 may comprise a plurality (2, 3, or more) of ribs C3106''.
  • the knob is a protrusion or ridge extending laterally and/or radially from the upper knob portion C1006a, C1106a, C3006a.
  • the knob allows a user to grip the cartridge connector easily between the finger in the thumb to facilitate placement in the pump chamber and to facilitate locking in the chamber.
  • the cartridge is locked and/or secured in the pump chamber by providing a quarter turn twist to the knob.
  • the grip ribs help the user develop the torque needed to connect the cartridge connector to the pump.
  • the detents and/or lugs give tactile feedback when the connection is made.
  • a shallow cam within the pump chamber is provided for the detent as it rotates into the connected position keeps the connection forces low.
  • a steep cam for the detent is used to cause the disconnect forces to be higher that the connection forces.
  • each of the cartridge connectors being shaped so as to provide a visual and/or tactile indication of when the cartridge connector is locked with the pump chamber.
  • a knob or other physical structure on the cartridge may indicate the orientation of the cartridge and whether the cartridge is in a locked position once the cartridge is inserted into the pump chamber.
  • Figure 6C illustrates an example of the cartridge connector providing a visual indication of when the connector is locked to the pump chamber. The depiction on the left shows cartridges inserted in, but not locked to, the pump chamber. The depiction on the right shows cartridges aligned with pump chamber after quarter turn to indicate locked state.
  • the ridges may also provide visual feedback.
  • the ridges are perpendicular to the pump face when in the locked position.
  • both knobs of the connectors C3001, C3101 are rotated in a clockwise fashion to lock the connectors in the pump P3000.
  • the cartridge connectors and pump openings may be configured to require a clockwise turn to lock one cartridge connector (and cartridge) in place and counterclockwise turning to lock the other cartridge connector (and cartridge) in place.
  • another indicator that allows a user to avoid mischanneling may be added.
  • the knob C1106 and the body C1102 of one connector C1101 may be one piece (e.g., a molded, unitary piece).
  • the knob C1006, C2006, C2106, C3006 and the body C1002, C2002, C2102, C3002 of a connector C1001, C2001, C2101, C3001 may be separately molded pieces fixed together (e.g., using an adhesive, sonic welding, heat staking, etc.).
  • the connector set can comprise either or both types of connectors (unitary or fixed together).
  • Figures 6M show the knob C3006 removed from the body (not shown).
  • the knob C3006 may comprise one or more fittings C3006x (e.g., protrusions, snap fit arms, receptacles, snap fit receptacles) that engage corresponding fittings of the knob.
  • a connector C1001, C2001, C2101, C3001 may comprise a projection C1007, C2007, C2107, C3007 extending axially upwardly from an upper surface of the body C1008, C2008, C2108.
  • the projection C1007, C2007, C2107, C3007 comprises a fluid outlet C1007', C2007', C2107', C3007' (e.g., connected to a through-hole or passage extending radially outward from, for example, a central fluid conduit in the projection).
  • the knob C1006, C2006, C2106, C3006, comprises a receptacle section C1006', C2006', C2106', C3006'.
  • the receptacle section C1006', C2006', C2106', C3006' is configured to extend over and receive at least a portion of the projection of the body C1007, C2007, C2107, C3007.
  • the receptacle section C1006', C2006', C2106' comprises a knob inlet C1006'', C2006'', C2106'', C3006'' configured to receive the medicament a medicament that passes through the fluid outlet C1007', C2007', C2107', C3007' of the connector body C1002, C2002, C2102, C3002.
  • an interstitial space C1009, C2009, C2109, C3009 is located between the projection of the body C1007, C2007, C2107, C3007 and the receptacle section C1006', C2006', C2106', C3006' of the knob C1006, C2006, C2106, C3006.
  • a flexible membrane C1020, C2020, C2120, C3020 is located within the interstitial space C1009, C2009, C2109, C3009 and extending over at least a portion of the projection of the body C1007, C2007, C2107, C3007.
  • the flexible membrane C1020, C2020, C2120, C3020 is configured to allow fluid to pass from the body outlet C1007', C3007' and into the knob inlet C1006'', C3006'' only after a threshold fluid pressure of the medicament is reached.
  • medicament vials having plungers are typically designed to have little or no resistance and/or friction between the plunger and the wall of the reservoir.
  • the plunger can move and distribute medicament with very little force applied to the plunger (e.g., even by moving the cartridge, lifting the pump comprising the cartridge, etc.). This unwanted distribution is caused by the plunger lifting off the drive nut of a pump.
  • configurations described herein avoid issues with low friction plungers and/or lift-off.
  • the membrane C1020, C2020, C2120, C3020 acts as a one-way valve and/or prevents lift-off.
  • the one-way valve allows fluid to pass only after reaching a threshold pressure (e.g., a crack pressure) at the membrane.
  • a threshold pressure e.g., a crack pressure
  • the threshold pressure needed to allow fluid flow passed the check valve is greater than any gravitationally induced hydrostatic pressure differential that might develop between the patient and the infusion system. For instance, hydrostatic pressure can develop when the infusion system is connected to a patient via the infusion base and the patient (or user) lifts the loaded pump (containing one or more medicament vial(s)) to an elevation over the infusion base. By force of gravity, the elevation of the vial pushes fluid from the vial through the conduit and into the patient via the infusion base set.
  • the amount of hydrostatic force applied is determined by the elevation of the medicament vial over the infusion set.
  • the amount of hydrostatic force therefore, is usually limited by the length of the fluid conduit (which ultimately connects the medicament vial to the infusion set).
  • a standard length of the fluid conduit is about 110 cm or about 60 cm.
  • the check valve is sufficiently resilient to remain closed when a vial of medicament in the infusion system is elevated over the infusion set by a distance of at least: about 220 cm, about 110 cm, about 60 cm, values between the aforementioned values, or ranges spanning those values.
  • the check valve is designed such that the threshold pressure gradient needed to allow fluid flow passed the check valve is greater than any hydrostatic pressure differential that might arise due to any other changes in the hydrostatic pressure between the patient and the infusion system (e.g., force caused by an airplane changing elevation, a carnival ride, bungee jumping, physical activity, etc.).
  • one or more radially extending passages C1007a, C2007a, C2007b, C2107a, C2107b, C3007a, C3007b pass through the projection C1007, C3007 terminating at a fluid outlet C1007', C3007'.
  • tunnel(s) provides a fluid path through the projection C1007, C2007, C2107, C3007 of the cartridge connector body C1002, C2002, C2102, C3002 ending at a side hole C1007', C3007' or a plurality of side holes C2007', C2107', C1007' (e.g., apertures, outlets, etc.).
  • the side hole abuts the membrane C1020, C2020, C2120, C3020.
  • Figures 7G and 7H show views of another example of a cartridge connector including a check valve.
  • the check valve includes standoff bumps C4020a.
  • a fluid path flows from the concave side of a check valve, around a proximal end of the check valve, and towards a convex side of the check valve.
  • a modified sheath e.g., cap feature
  • Fluid moves under the sheath via spaces made between the pictured standoff bumps (which are distributed around the sheath) the provide a path to the end of the cap feature.
  • fluid flows up the needle (from the drug cartridge).
  • the fluid abuts the sheath.
  • the connector C1101 is configured to receive the medicament through the needle C1103 and to deliver the medicament out of the knob C1106 from the fluid outlet C1130.
  • a connector C1001, C2001, C2101, C3001 comprising a flexible membrane C1020, C2020, C2120, C3020
  • the connector C1001, C2001, C2101, C3001 is configured to receive the medicament through the needle C1003, C2003, C2103, C3003 and to deliver the medicament out of the connector through a fluid outlet of the connector C1030, C2030, C2130, C3030.
  • the needle C1003, C1103, C2003, C2103, C3003 and the fluid outlet of the connector C1030, C1130, C2030, C2130, C3030 are in fluidic communication and provide a fluid path through the connector C1001, C1101, C2001, C2101, C3001.
  • each connector may comprise a projection C2007, C2107 extending axially upwardly from an upper surface of the body C2008, C2108, a receptacle section C2006', C2106', a knob inlet C2006'', C2106'', an interstitial space C2009, C2109 located between the projection of the body and the receptacle section of the knob C2006, C2106 and a flexible membrane C2020, C2120.
  • each connector and or a plurality of connectors in a connector set may comprise a one-way valve.
  • a single connector may comprise a one-way valve (and not both and/or and not more than one).
  • an underside of the knob C1022, C1122, C2022, C2122, C3022 may comprise one or more nubs C1021, C1121, C2021, C2121, C3022 (e.g., projections, protrusions, small lumps, protuberances, etc.).
  • these nubs are crushable and/or malleable.
  • these nubs are rigid and/or are not crushable and/or malleable.
  • these nubs ensure and/or encourage a tight (e.g., snug, flush, space-free vibration-free, and/or rattle-free) engagement of a connector to the pump.
  • a tight e.g., snug, flush, space-free vibration-free, and/or rattle-free
  • the longitudinally extending threads e.g., traveling distally down the bore
  • the nubs ensure that at least a portion of the connectors contact the upper side surface of the pump to hold the connectors tightly in place against the upper side surface. It has been noted that, in the absence of nubs and where space exists between the cartridge connector and the pump housing, the cartridge connector can inadvertently be pushed flush against the pump housing (e.g., at the upper side surface) which, in turn, pushes the cartridge within the pump against the drive nut, delivering a small bolus. In some embodiments, the nubs allow the connectors to mold to the upper side surface of the pump (so that each attachment and reattachment of a connector provides a flush connection without space between the pump and the cartridge connector).
  • the nubs in combination with the detent cams (or lug cams) provide added stability to the system. Additionally, manufacturing tolerances for the cartridge connectors (which may be disposable) is increased through use of the nubs. For example, the cartridge connectors need not be manufactured to exactly conform to a particular upper surface of a pump as the nubs aid in forming a snug / tight fit between the upper surface of the pump and the cartridge connector.
  • recognition features P1101, P1102, P1103, P1111, P1112, P1113, C1010, C1011, C1110, C1111, C1012, C1112, C3010, C3011, C3012 may be provided and can be configured to prevent or inhibit mischannelling.
  • cartridge connectors C1001, C1101 corresponding to the pump receptacles P1100, P1110 comprise corresponding protrusions C1010, C1011, C1110, C1111, C1012, C1112 (e.g., tabs, lugs, detents) to the openings of the pump chambers P1101, P1102, P1103, P1111, P1112, P1113.
  • these protrusions include lugs C1010, C1011, C1110, C1111 and/or detents C1012, C1112.
  • cartridge connectors C2001, C2101 corresponding to the pump receptacles P2100, P2110 comprise corresponding protrusions (e.g., tabs, lugs, detents).
  • these protrusions include lugs C2010, C2011, C2110, C2111 and/or detents C2012, C2112.
  • the protrusions e.g., projections
  • the protrusions are configured to mate with (e.g., slide into) corresponding openings configured to receive such projections.
  • each cartridge connector may have a plurality of recognition features.
  • each connector C1001, C1101, C3001 comprises three radially extending protrusions (lugs and detents) configured to engage correspondingly shaped carve-outs of corresponding cartridge receptacles.
  • lugs and detents radially extending protrusions
  • These recognition features may be configured to engage an appropriate receptacle, to prevent or inhibit engagement of an improper cartridge connector (e.g., that is not corresponding and that lacks one or more corresponding protrusions), or both.
  • each connector has three radially extending protrusions as recognition features
  • each connector can independently have one, two, three, four five, or more recognition features (e.g., divots and/or protrusions) configured to engage and/or receive corresponding recognitions features (e.g., protrusions and/or divots) from corresponding pump chambers.
  • recognition features e.g., divots and/or protrusions
  • corresponding recognitions features e.g., protrusions and/or divots
  • the cartridge connectors have been described as comprising circumferentially distributed protrusions and the pump chambers as comprising circumferentially distributed divots, the opposite configuration is also possible (where protrusions are on the cartridge connectors and divots on the receptacles).
  • types of recognition features could be mixed and matched on a particular cartridge connector (so the connector comprises both protrusions and divots and the corresponding receptacle has corresponding divots and protrusions).
  • a cartridge connector can comprise only divots and a different cartridge connector in the same connector set can comprise only protrusions.
  • the corresponding cartridge receptacle can comprise corresponding protrusions and a cartridge receptacle can comprise corresponding divots, respectively.
  • the lugs and detents may be various different sizes (e.g., circumferential lengths, radial heights, etc.).
  • a lug of one cartridge connector may be of one length lug(cl')
  • a second may be of a second length lug(cl'')
  • these lengths may be different from each other and/or from the lug lengths of a second cartridge connector lug(cl'''), lug(cl'''').
  • a detent of one cartridge connector may be of one length det(cl') that is different from a detent length det(cl'') of the other cartridge connector.
  • these lugs and detents are configured to insert into correspondingly sized (e.g., of corresponding lengths) openings located on corresponding cartridge receptacles.
  • detents and lugs of two different connectors may have corresponding positions (e.g., when the middle feature is rotated to 12 o’clock, a first lug is at 9 o’clock, a detent is at 12 o’clock, and a second lug is at 3 o’clock, etc.).
  • the lugs and detents are not in corresponding positions or only a portion of the lugs and detents are in corresponding positions.
  • the attachment of an incorrect cartridge connector can be prevented and/or substantially hindered by providing different sizes of those equivalently positioned features.
  • a feature on a first connector e.g., a lug opening, a detent opening, a lug, a detent, etc.
  • a second connector e.g., a feature that is in the same relative position
  • mischanneling can be prevented and/or substantially inhibited.
  • the ratio of the length of a feature of one connector as compared to the length of an equivalent feature on a different connector is equal to or at least about: 3:1, 5:2, 2:1, 5:3, 4:3, 20:17, or ranges spanning and/or including the aforementioned ratios.
  • a plurality of recognition features may be distributed around the periphery of cartridge connectors C1001, C1101, C3001 (e.g., circumferentially).
  • a plurality of recognition features e.g., lugs, detents, openings configured to receive lugs or detents, etc.
  • the mid-point of one recognition feature C1012 may be positioned at the 9 o’clock position and an adjacent recognition feature may have a midpoint at 12 o’clock C1011, thereby being separated by 90°.
  • adjacent recognition features of the connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise.
  • non- adjacent recognition features of the connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise.
  • the cartridge connectors may include, instead of and/or in additional to protrusions, divots (not shown). In some embodiments, the divots may open to tracks (e.g., slots, paths, etc.).
  • these paths may travel and/or are positioned circumferentially around the connectors.
  • the connector is rotated to lock the cartridge connector into the receptacle (as disclosed elsewhere herein).
  • the individual cartridge connector shrouds may be formed to prevent attachment of the incorrect cartridge connector with the incorrect medicament cartridge.
  • a first cartridge connector may have a shorter skirt.
  • a second cartridge connector C1101, C2101 may be formed to have a longer shroud (e.g., skirt) than the first cartridge connector C1001, C2001 (e.g., an insulin cartridge connector).
  • one connector can have a wider diameter the other a smaller diameter.
  • a first cartridge M1001 e.g., the insulin cartridge
  • a second cartridge M1101 e.g., the glucagon cartridge
  • the shroud of the insulin cartridge is longer to avoid engaging a glucagon cartridge that may be wider than the insulin cartridge.
  • additional features of the connectors may include one or more of a needle that is recessed within the connector above the shroud.
  • the connector set comprises one or more cartridge connectors that couple the fluid conduits (shown in Figures 8A and 8B) to the medicament reservoirs.
  • the reservoirs (or reservoir) are located in (and/or can be placed in) a pumping device configured to distribute the medicament from the reservoirs (or reservoir) to the conduit, thereby supplying the system with medicaments.
  • the fluid conduits provide separate pathways that terminate at designated delivery members (e.g., needles, cannulas, etc.) within the base, thereby enabling independent delivery (e.g., subcutaneous or otherwise) of medicaments separately.
  • designated delivery members e.g., needles, cannulas, etc.
  • the fluid conduits e.g., of the lumen assembly
  • one or more connectors may be provided with fittings C1150, C3050 that allow disconnection and reconnection of the connector C1101, C3001 with the lumen assembly (partially shown) via a corresponding fitting T1150 located on a fluid conduit T1101 of the lumen assembly (e.g., multi-channel lumen assembly).
  • either or both of the connector C3001 and the fluid conduit T1101 attachments can be closeable or resealable male or female fittings (e.g., connectors), such as a resealable female luer connector T1150 and a resealable male luer connector C1150, C3050 with a male protrusion C1151, C3051 as the fluid outlet C1130, C3030, as shown.
  • the connector C1101, C3001 may comprise the male fitting C1150, C3150 and the fluid conduit T1101 of the multi-channel lumen assembly may comprise the female fitting T1150.
  • the connector may comprise the female fitting and the fluid conduit of the multi-channel lumen assembly may comprise the male fitting.
  • the connector C1101 may comprise a tail C1160 (e.g., a length of fluid conduit) that extends from and is in fluidic communication with the connector C1101.
  • the tail C1160 is a length of fluid conduit (e.g., a channel, lumen, etc.) that terminates at the fitting C1150 providing fluidic communication between the connector C1101 and the fitting C1150.
  • the fitting C3050 may comprise a portion of the upper knob portion C3006a of the knob C3006.
  • a fitting of the fluid conduit T1101 and/or of the connector C1140, C3050 can include an ISO 594-compliant luer taper.
  • the fitting may comprise a shroud C1153, C3053 (e.g., a skirt) that is threaded C1152, C3052 that is configured to receive a corresponding feature T1153 (e.g., threading, a thread, a lip, etc.) of the fluid conduit T1101.
  • the fittings are not threaded.
  • the female portion is configured to snuggly receive an interfacing male portion (e.g., is snug-fit).
  • the snug fitting provides added strength and/or stability to the connection between the coupling features. In some embodiments, this strength and/or stability can beneficially prevent movement, bending, breakage, or disconnection of the coupled components.
  • the female connector T1150 may comprise cinching features T1155 (e.g., protruding wings, a textured surface, or other implements that allow the connector to be grasped) that allow the connector to be twisted using the fingers to provide a tight connection with the corresponding male C1150, C3050 connector.
  • either or both of the fittings of the fluid conduit and the connector can include a connection structure, such as one or more threads (as shown), clasps, arms, latches, protrusions, and/or recesses, etc., that is configured to help guide, attach, and/or retain the cartridge connector to the fluid conduit.
  • the connection structure can comprise one or more disconnection- resisting features or structures configured to resist disconnection between the connector and the fluid conduit.
  • the disconnection-resisting features(s) or structure(s) can have many different forms, such as one or more freely spinning positions or stages after connection is accomplished, one or more increased friction-inducing anti-rotation impediments, and/or one or more disconnection-resisting thread shapes.
  • a friction-inducing impediment can comprise one or more (e.g., at least two) protrusions positioned between multiple thread turns, the one or more protrusions extending radially outwardly from the inner surface of the threading, thereby providing a region of radial space between the radially outermost surface of the protrusion and the radially outermost surface of the threading that is smaller than the radial space between the inner surface of the threading and the outermost surface of the threading.
  • the relative rotation of the two fittings is slowed down or resisted through increased frictional contact between the impediment and the threading of the fluid conduit connector, thereby requiring greater torque to attach the two fittings and/or requiring greater torque to detach the two fittings, which diminishes the risk of accidental disconnection.
  • the contact between the impediment and the threading of the fluid conduit connector may cause wedging, compaction, crushing, and/or compression of either or both fittings (or structures within the fittings).
  • Many different types of impediments can be used to resist disconnection that are different from those described and/or illustrated.
  • a disconnection-resisting thread shape can help resist or prevent disconnection between the connector fitting and the fluid conduit fitting.
  • a helical threading with multiple thread turns can comprise a thread portion with an oversized region, and/or an outwardly flaring or outwardly tapering region.
  • the outermost diameter of a beginning thread portion can be a first diameter that is a standard size or within a standard range of sizes, such as may be specified in any applicable medical device standard (e.g., any of those mentioned elsewhere in this specification), or slightly smaller than a standard size or range of sizes.
  • the diameter of a portion of either thread can flare or taper (e.g., outwardly to a non-standard second diameter than is larger than the first diameter and larger than the diameter or range of diameters specified in one or more applicable medical device standards). Since the fitting of the fluid conduit to which the proximal region of the connector fitting is configured to attach will typically have a standard diameter of threading, the outward taper or flare of the disconnection-resisting thread shape of the connector fitting can cause the space between the respective threads to decrease, or can cause the attachment region of the fitting of the fluid conduit to stretch by a small amount, and/or can cause the threading of the fitting of the fluid conduit to compress by a small amount.
  • One or more of these effects can create opposing radial forces between the threading surface of the fitting of the fluid conduit and the connector, which can increase the friction between the respective surfaces and thereby resist or prevent rotational movement and decrease the risk of accidental disconnection between the two devices.
  • Many other different types of disconnection-resisting or disconnection-preventing features can be used instead of or in addition to those illustrated and/or described in this disclosure, including one or more structures not including thread shapes or impediments, or any type of threads at all.
  • the snap-arm comprises a lip (e.g., a tooth, ridge, etc.) configured to engage the cap and/or neck of a cartridge.
  • these snap arms are in a position that ensures the cartridge is extracted from the pump when the cartridge connector is disconnected. In some embodiments, without this connection, the cartridge could be stuck in the pump by the forces on the Plunger/Pump connection. As shown, the longer skirt of a cartridge connector (e.g., glucagon) will hit a larger diameter cartridge (e.g., insulin) preventing the snap connection of the snap arms.
  • the first medicament cartridge is configured to receive insulin.
  • the second medicament cartridge is configured to receive glucagon.
  • the cartridge connector cannot rotate into the locked position within a pump if the cartridge snaps are not closed.
  • a recognition feature of the second cartridge connector (e.g., the skirt ring, snap arms, etc.) is configured to block attachment of the second cartridge connector within the first pump receptacle.
  • a recognition feature of the first cartridge connector is configured to block attachment of the first cartridge connector within the second pump receptacle.
  • features of a cartridge e.g., its diameter, neck position, etc.
  • features of a second cartridge M1101 are configured to block engagement of the second cartridge M1101 with a first connector C1001, C2001.
  • the first cartridge M1001 is configured to interact with the first cartridge connector C1001, C2001 and/or not the second cartridge connector C1101, C2101.
  • the second cartridge M1101 is configured to interact with the second cartridge connector C1101, C2101 and/or not the first cartridge connector C1001, C2001.
  • features of the cartridges e.g., diameter, neck position, cap width and length, etc.
  • Figures 7F, 8A 8B, and 8D- 8E show exemplary features. As shown in Figure 8A, when properly seated in the connector, the needle C1003, C1103 of the connector C1001, C1101 pierces the septum M1004, M1104 substantially perpendicularly.
  • Some embodiments pertain to methods of making a cartridge connector.
  • the cartridge connector is made by employing one or more of the following steps: a needle is bonded to the body; a tube is bonded to the knob; a check valve (e.g., a flapper valve) is set onto a “valve seat” of the body and/or a membrane is stretched over the connector projection; the knob and body are fixed together (e.g., sonically welded together, snapped together, glued, otherwise affixed, etc.).
  • a needle is bonded to the body
  • a tube is bonded to the knob
  • a check valve e.g., a flapper valve
  • a membrane is stretched over the connector projection
  • the knob and body are fixed together (e.g., sonically welded together, snapped together, glued, otherwise affixed, etc.).
  • the cartridge connector is made by a method employing one or more of the following steps (but lacking others): a needle is bonded to the body; a tube is bonded to the knob; a check valve is set onto the “valve seat” of the body and/or a membrane is stretched over the connector projection; the knob and body are fixed together.
  • the tube mounting hole in the knob may be tapered so that the tube will contact the wall around the perimeter before bottoming out in the hole. This creates a seal to prevent adhesive from running down into the check valve area when gluing the tube into the knob.
  • the cartridge connector can be made by employing one or more of the following steps: the Needle is bonded to the Body; the Tube is bonded to the Knob.
  • the lumen assembly comprises one or more lumens (or tubes).
  • the lumen assembly is a multi-lumen assembly comprising a plurality of tubes (e.g., 1, 2, 3, or more).
  • the lumen assembly comprises a cartridge connector (or a cartridge connector set).
  • the lumen assembly comprises a fitting T1150 that engages a fitting C1150, C3050 of a connector C1101, C3001 (e.g., of a cartridge connector set).
  • the lumen assembly comprises an infusion site connector (or an infusion set).
  • the lumen assembly is a part of an ambulatory infusion system, as disclosed elsewhere herein.
  • an infusion system comprising the lumen assembly set is provided.
  • a lumen assembly T1000 of a multi-lumen assembly is shown in Figure 9A with the cartridge connectors, fitting(s), and/or infusion site connectors removed.
  • the illustrated multi-channel lumen assembly includes a first tube T1001 and a second tube T1101, respectively, forming medicament passages or channels.
  • the first tube T1001 forms a first medicament channel and the second tube T1101 forms a second medicament channel.
  • the first and second tubes comprise the first and second cartridge connectors C1001, C1101, respectively.
  • the first end portion T1001a may be configured to engage or may be fused with the first connector C1001.
  • the first end portion T1101a of the second tube T1101 may be configured to engage or may be fused with the second connector C1101.
  • the second end portion T1001b of the first tube T1001 may be configured to engage or may be fused with a first infusion connector 2533.
  • the second end portion T1101b of the second tube T1101 may be configured to engage or may be fused with a second infusion connector 2432.
  • the first and second tubes comprise the first and second fitting(s) T1101, such as provided in Figures 7I and 7J.
  • the first ends of the first and second tubes respectively, provide the infusion pump side of the multi-channel lumen assembly.
  • the first ends may be proximally located to the cartridge connectors and distally located with reference to the infusion connectors.
  • the second ends of the first and second tubes may provide the infusion set side of the multi-channel lumen assembly.
  • the second ends may be proximally located to the infusion connectors and distally located with reference to the cartridge connectors.
  • the tubes of the multi-channel lumen assembly can be configured so as to be able to be coupled together and then, if desired, be detached or decoupled from each other. This can preferably be done repeatedly.
  • the tubes can have formed thereon mating connecting features T1010 that allow the tubes to be coupled together over at least a portion of the length of the tubes.
  • the first tube can employ a surface feature, such as a tongue-like rail portion, that is formed on and extends outwardly from the main body of the tube.
  • the patient can replace one or both of the tubes as needed rather than dispose of both tubes at the same time as is required in systems where the tubes are permanently connected.
  • the tubes of the multi-channel lumen assembly may be fused and/or permanently affixed to one another.
  • the lumen assembly comprises a cartridge connector (or a cartridge set) but not an infusion site connector.
  • the lumen assembly comprises an infusion site connector (or an infusion set), but not a cartridge connector.
  • the lumen assembly comprises an infusion site connector (or an infusion set) and one or more fittings that connect to a cartridge connector.
  • an infusion connector (or an infusion connector set) is a part of an ambulatory infusion system, as disclosed elsewhere herein.
  • the infusion system comprises an infusion connector set and/or infusion bases and a multi-channel lumen assembly.
  • the infusion system (e.g., infusion set) comprises an infusion connector set and/or infusion bases, a multi-channel lumen assembly, and a cartridge connector set.
  • the infusion system comprises an infusion connector set and/or infusion bases and one or more of a cartridge connector set, medicament cartridges, and an infusion pump.
  • Figures 10A-B are isometric views showing a portion of a dual- medicament infusion set.
  • Figure 10A shows an embodiment of a dual-medicament site base inserter 2426 attached.
  • Figure 10B the dual-medicament site base inserter 2426 has been removed.
  • the dual-medicament site base inserter 2426 couples two disjoint halves: the right site base hub 2424 (e.g., the second base, the glucagon base, etc.), and the left site base hub 2525 (e.g., the first base, the insulin base, etc.).
  • the inserter is configured to insert the base of a single infusion base 3401.
  • the inserter 2426 provides a handle for the application of the dual-medicament infusion site base 2401.
  • the base 2401 includes one or more needle guards 2429, 2529.
  • the infusion set base 2401 comprises one or more release liners 2428, 2528, 3428.
  • the infusion set base 2401, 3401 comprises an adhesive 2427, 2527, 3427 (e.g., a tape, gel, rubber adhesive, etc.).
  • the dual-medicament site base inserter 2426 can be used to apply the dual-medicament infusion set base 2401, 3401.
  • the needle guard protects a needle (2008a, 2008b) or other delivery conduit (such as a cannula).
  • the needle or delivery conduit terminates at an aperture that delivers a medicament into the patient.
  • the adhesive tape 2427, 2527, 3427 e.g., adhesive layer, adhesive pad, etc.
  • the dual-medicament site base inserter 2426 is disposable and is removed by activating the two living hinges 2436, 2536 and sliding the dual-medicament site base inserter 2426 out of the retention slots 2430, 2530 (shown in Figure 12B) to reveal the two posts 2431, 2531 that are part of docking stations 2005, 2105 that are now ready to accept site connectors (see Figures 11A-B).
  • the posts 2431, 2531 are asymmetric.
  • the infusion set inserter 2426 is reusable and can be reattached to the site base hubs 2424, 2525, 3424.
  • the infusion set includes a connector cover 2434.
  • Figure 11A is an isometric view showing the dual-medicament infusion site connectors 2432, 2533 with a dual-medicament site connector cover 2434 attached. In some embodiments, as shown, fluid conduits from the cartridge connectors may be attached to the infusion site connectors.
  • Figure 11B shows the dual-medicament infusion site connectors after the dual-medicament site connector cover 2434 has been removed. In some embodiments, the dual-medicament site connector cover 2434 couples the two disjoint halves: the second site connector 2432, and the first site connector 2533.
  • the site connector cover 2434 protects the site connectors 2432, 2533 from exposure (e.g., to dust, dirt, abrasion, physical damage, etc.) when they are not connected to the dual-medicament infusion site base 2401 (shown in Figure 10A).
  • the first site connector 2533 can be disconnected from the dual-medicament site connector cover 2434 by activating the living hinge 2536 to release the retention clip 2535 and then sliding the first site connector 2533 out of the retention slot 2530 (shown in Figure 12B).
  • Disconnection of the first site connector 2533 from the dual-medicament site connector cover 2434 reveals the alignment posts 2539 and the asymmetric post receptacle 2538 which mate with corresponding features on the left site base hub 2525 (shown in Figure 10B).
  • the same procedure can be used to disconnect the second site connector 2432 from the dual- medicament site connector cover 2434, using corresponding features and similarly tens-place enumerated features (e.g., 2436 corresponds to 2536).
  • the order of disconnection from the dual-medicament site connector cover 2434 and reconnection to the dual-medicament infusion site set base 2401 is arbitrary.
  • the infusion of two different hormones can be accomplished using a single infusion site or through an infusion set comprising a single infusion base, as shown in, for example, Figures 12C-12I.
  • the design beneficially lowers the amount of injection sites or the amount of bases attached to the skin.
  • the infusion set utilizes a plastic cannula design for the primary hormone and a steel needle site design for the secondary hormone.
  • the infusion set utilizes a plastic cannulas for the primary hormone and the secondary hormone.
  • the infusion set utilizes a dual lumen cannula, one lumen for the primary hormone and the secondary hormone.
  • the infusion site base 3401 comprises a hub 3424.
  • the hub comprises an upper surface 3402, a bottom surface 3403, and a side surface 3404.
  • the side surface may comprises multiple perimeter surfaces (e.g., 1, 2, 3, 4, or more).
  • the hub comprises a first docking station 3005 comprising a coupling feature and a port (which are engaged in Figures 12C-12F and therefore not visible.
  • the first docking station 3005 being configured to receive a first infusion connector 3005a and to couple to it to the hub via the coupling feature of the first docking station.
  • the hub comprises a second docking station 3006.
  • the second docking station 3006 comprising a coupling feature and a port 3007.
  • the port 3007 comprises a septum 3010a.
  • the septum 3010a is configured to be punctured by a piercing element 3008b, 3008d of an infusion connector 3006a (e.g., a second infusion connector) of the infusion set (as shown in Figure 12G and 12I).
  • the second docking station 3006 is configured to receive a second infusion connector 3006a and to couple to it to the hub 3424 via the coupling feature of the second docking station.
  • the infusion connector 3006a may have features common with other site connectors disclosed elsewhere herein.
  • the first infusion connector may include an alignment post and a post receptacle which mate with corresponding features on the base hub.
  • infusion set 3401 comprises a delivery conduit.
  • the delivery conduit is a coaxial delivery conduit 3008 extending distally from the hub 3424 and passed the adhesive 3427.
  • the coaxial delivery conduit 3008 comprises a first tubular member 3008a having a first lumen and a second tubular member 3008b comprising a second lumen.
  • the delivery conduit may comprise two separate tubular members (e.g., tubular delivery members) that are provided on different infusion bases.
  • the delivery conduit may be provided on a single infusion base and the delivery conduit may or may not be coaxial).
  • a tubular delivery member can comprise metal (e.g., stainless steel, etc.), polymer (e.g., plastic, polyurethane, Teflon, biocompatible polymer materials, etc.), or other suitable materials for delivering medicine to a patient.
  • the tubular delivery member is configured to delivery medicine to a patient transdermally, intradermally, subcutaneously, intramuscularly, intravenously, etc.
  • the tubular delivery members may be the same or different materials.
  • one tubular member may be a rigid material and the other may be flexible material.
  • both tubular members together may be made out of and/or comprise a flexible material (e.g., soft catheters). In other embodiments, where two tubular members together provide the delivery conduit, both may be made out of and/or comprise a rigid material.
  • one delivery member may be housed (e.g., partially or completely) in a second delivery member (e.g., having at least a portion that is coaxial). In other embodiments, a first and a second deliver member may be separate from one another (e.g., lacking a coaxial portion).
  • the flexible material for each tubular member may be the same or different.
  • an outer tubular member (e.g., in a coaxial arrangement) may be made of a nonstick material (e.g., Teflon, etc.) to aid in placement within the patient.
  • An inner tubular member may be another material selected for its biocompatibility.
  • the rigid material for each tubular member may be the same or different.
  • Alternative configurations are envisioned, as will be appreciated by the disclosure provided herein.
  • a delivery conduit may be rigid (e.g., a metal, a rigid plastic, etc.) or flexible (e.g., a soft plastic or polymeric material, etc.).
  • first and second tubular member may act as piercing elements during insertion into the skin by an infusion set inserter.
  • first tubular member and the second tubular member are flexible (e.g., flexible cannulae).
  • an inserter having one or more piercing elements may be used to insert the tubular members into the patient.
  • a coaxial delivery conduit may be provided.
  • the coaxial delivery conduit 3008 comprises a first tubular member 3008a having a first lumen and a second tubular member 3008b comprising a second lumen.
  • the first and second lumens may terminate at first and second apertures 3008a*, 3008b*, respectively.
  • the second tubular member 3008b is disposed at least partially within the first lumen of the first tubular member 3008a of the coaxial delivery conduit.
  • the first lumen of the first tubular member 3008a is in fluidic communication with a piercing element 3008c of the first infusion connector 3005a that enters the hub via a port of the first docking station 3005b.
  • the port of the first docking station 3005b comprises a septum 3010b that is pierced by the piercing element 3008c of the first infusion connector 3005a.
  • the second lumen of the second tubular member 3008b is in fluidic communication with the port of the second docking station.
  • the second lumen of the second tubular member 3008b is a part of the second infusion connector 3006a, as shown in Figures 12D-12G.
  • the first docking station 3005 is located on the side surface 3404 of the hub 3424 and the second docking station 3006 may be located on an upper surface 3402 of the hub 3424.
  • the top down approach of the second infusion connector 3006a to the hub 3424, as shown in Figures 12D-12I is referred to as piggy backing configuration.
  • the piggy backing configuration is achieved when the first infusion connector 3005a is connected to the hub via a lateral approach and the second infusion connector 3006a is connected to the hub via a port on the upper surface of the hub.
  • the piggy backing configuration makes the dual medicament infusion set more compact.
  • the first tube T1001 and the second tube T1101 may be positioned in line with each other.
  • the first and second tube are disposed over (and/or approximately over) and/or in line with one another (and/or approximately in line with one another). In several embodiments, this lowers the clutter associated with the infusion set, making it more compact.
  • the first and second tube may have clips that allow them to attach together, further securing them and/or avoiding clutter associated with free tubes.
  • the first and second tube may be welded or otherwise affixed to one another.
  • the first lumen of the first tubular member 3008a is not in fluidic communication with the second lumen of the second tubular member 3008b.
  • the second tubular member 3008b may extend distally farther from the hub 3424 (e.g., and/or the base 3401 or adhesive 3427) than the first tubular member 3008a.
  • the second tubular member extends distally from the hub to a distance farther from the hub than a distance to which the first tubular member extends.
  • the second lumen and the first lumen may be in fluidic communication.
  • the second tubular member terminate within the first tubular member, causing the lumens of the second tubular member to expel its contents within the first tubular member.
  • the second tubular member extends to a distance from the hub that is equal to or less than a distance to which the first tubular member extends.
  • the infusion connector conduit (e.g., that leads to the infusion set and/or an infusion connector) may have a dual lumen (with a first lumen T1001* and second lumen T1101*) configuration configured to receive medicament from both a first fluid conduit (e.g., the first tube T1001) and a second fluid conduit (e.g., the second tube T1101).
  • first tube T1001 and second tube T1101 may come together to provide a conduit T1000* having a dual lumen.
  • Figure 12Ji and 12Jii Such an embodiment is shown in Figure 12Ji and 12Jii.
  • a single infusion base 4001 comprising a single base hub 4424 may be configured to engage a single infusion connector 4005a.
  • the dual lumen connector conduit T1000* is configured to distribute the contents of each lumen T1001*, T1101* into a single delivery conduit 4008a (e.g., a tubular delivery member).
  • the base may be adhered to the skin through an adhesive layer 4427.
  • the dual lumen infusion connector conduit can be used with any cartridge connector provided elsewhere herein. For instance, the first and second tube of the cartridge connectors may join to provide the dual lumen tube.
  • the first tubular member (e.g., the outer tubular member in coaxial embodiments) is flexible. In several embodiments, the first tubular member is a cannula. In several embodiments, the second tubular member (e.g., the inner tubular member in coaxial embodiments) is flexible. In several embodiments, the second tubular member is a cannula.
  • Figure 12H shows an embodiment of a dual medicament system with a dual cannula where both tubular members 3008a, 3008b may be flexible. Alternatively, in several embodiments, the first tubular member may be rigid and/or the second tubular member may be rigid.
  • the first tubular member is a piercing element (e.g., a steel piercing element, needle, etc.).
  • the second tubular member is a piercing element (e.g., a steel piercing element, needle, etc.).
  • the first tubular member may be flexible and the second tubular member may be rigid.
  • the second tubular member 3008b may be longer than the first tubular member 3008a. In several embodiments, length may be measured as the distance a tubular member extends away from the adhesive layer of the infusion site base.
  • length may be measured as the distance a tubular member extends away from the hub of the infusion site base.
  • the second tubular member is substantially the same length, about the same length, or the same length as the first tubular member.
  • the first tubular member is longer than the second tubular member.
  • the ratio of the length of the first tubular member to the second tubular member is equal to or at least about: 4:1, 3:1, 2:1, 3:2, 4:3, 5:4, 6:5, 1:1, 5:6, 4:5, 3:4, 2:3, 1:3, 1:4, ratios between the aforementioned ratios, or otherwise.
  • a tubular delivery member (e.g., the first and second tubular delivery member) may terminate at an aperture 2008a*, 2008b*, 3008a*, 3008b*, 4008*.
  • the tubular deliver member may have lateral apertures 3008a' along the delivery member 3008a.
  • the apertures 3008a' allow fluid to disperse around the first tubular member 3008a.
  • the lateral apertures 3008a' allow medicine to flow in an unobstructed manner.
  • the lateral apertures may be sized and/or may be distributed along the first tubular member at different densities to better distribute medicine evenly and/or at desired portions along the first tubular member. For instance, where even distribution is desired along a portion of the first tubular member, the lateral apertures closest to the hub may be smaller than those farther from the hub. By having a size gradient (e.g., where the size of the lateral apertures increases farther from the hub), the larger apertures further from the hub are able to distribute medicament at a rate (or in an amount) substantially equally to apertures closer to the hub.
  • the density of apertures may increase further from the hub to allow even distribution.
  • other configurations are possible (with gradients having higher distribution closer to the hub). This configuration may be used to better avoid a medicament from interfering with the action of the other medicament.
  • a tubular member may lack an end aperture and instead, the terminal end may be sealed 3008** (e.g., plugged, welded closed, etc.).
  • the interaction of the first and second medicaments delivered through the first and second deliver members, respectively, is lessened and/or prevented.
  • embodiments with dual infusion bases 2424a, 2525a may also have lateral apertures 2008a', 2008b' configured to deliver a medicament.
  • the lateral apertures 2008a', 2008b' may be distributed evenly about the delivery member(s).
  • the first and second lumens may terminate at first and second apertures 2008a*, 2008b*, respectively, or the first and second lumens may be sealed to provide distribution through the later apertures (not shown).
  • the lateral delivery apertures may be located on a portion of a delivery member. As disclosed elsewhere herein, in several embodiments, the lateral delivery apertures are more densely distributed at the terminal end and less dense at the proximal end of the delivery member. As noted elsewhere herein, the apertures may be arranged as a gradient along a portion of the delivery conduits to achieve tailored distribution about the delivery conduit. In several embodiments, as shown in Figure 12N, the proximal end of a delivery member may lack lateral delivery apertures.
  • a proximal end of one delivery member may lack lateral delivery apertures and a proximal end of the other delivery member may have lateral delivery apertures.
  • this configuration helps ensure delivery of medicaments (e.g., regulatory and counter-regulatory agents) in a manner that minimizes and/or lowers the likelihood of their interaction after delivery.
  • the first tubular member may be a cannula and, as shown in Figure 12E, the second tubular member may be a rigid element (e.g., a needle, a metal tube, etc.).
  • having the second tubular member be rigid beneficially allows its insertion through the hub after the first tubular member is implanted beneath the skin.
  • the first tubular member of the coaxial delivery conduit is implanted beneath the skin (e.g., by an inserted with an inserter needle that protrudes through the first tubular member).
  • the rigid tubular member can then be inserted into the first tubular member.
  • the second tubular member and the first may both be flexible materials (e.g., such as a cannula within a cannula), as shown in Figure 12H.
  • both the first and second tubular member of the coaxial delivery conduit are implanted beneath the skin (e.g., by an inserted with an inserter needle that protrudes through both cannulae).
  • the hub may include a guide that directs the second tubular member into the first tubular member (e.g., into the lumen of the first tubular member).
  • the guide helps avoid tearing or puncture of the first tubular member by the second tubular member (e.g., where the first tubular member is flexible and/or where the first tubular member is not rigid).
  • the guide may be funnel shaped and/or may comprise walls that slant toward a bottom port such that the second tubular member enters the port.
  • the guide comprises a wall (or walls) that align the second tubular member at a particular angle.
  • the guide aligns the second tubular member with the mouth and/or lumen of the first tubular member as the first tubular member is in the skin.
  • the guide is also used and/or configured to position the inserter probe (e.g., a piercing element of the inserter) of the inserter.
  • the inserter As the inserter is directed and/or projected into the skin, it positions the first tubular member at a particular position (e.g., in three-dimensional space) under the skin.
  • the inserter (and probe) when the inserter (and probe) is withdrawn, it leaves the first tubular member in a path determined by the alignment feature of the hub (e.g., the guide). Then, as the second tubular member is inserted through the guide, it follows the same path as the probe, and is directed into the first tubular member.
  • the guide positions the second tubular member at a particular position (e.g., in three-dimensional space) under the skin that is the same as the position as the first tubular member.
  • the second tubular member may be rigid but the end portion is blunt (e.g., rounded, not sharp, etc.) to avoid piercing the first tubular member.
  • the second infusion connector may comprise a rigid tubular member.
  • the tubular member 3008d (shown in Figure 12H) is rigid.
  • the rigid tubular member 3008d is configured to deliver a medicament to the base hub 3424 (e.g., into the base hub).
  • the rigid tubular member may be of insufficient length to span the distance between the upper surface of the hub to the bottom surface.
  • the rigid tubular member terminates in the hub when coupled to the base via the second docking station of the hub.
  • the rigid tubular member 3008d of the second infusion connector terminates at an aperture (and/or within) the second tubular member.
  • the second tubular member is configured to receive a medicament from the rigid tubular member of the second infusion connector.
  • the shorter tubular member of the second infusion connector 3006a distributes medicament into the second lumen of the second tubular member.
  • the fluid conduit may be multi-lumen (e.g., dual lumen).
  • the first lumen 3009a of the dual lumen fluid conduit is in fluidic communication with a medicament delivered by the first infusion connector.
  • the second lumen 3009b of the dual lumen fluid conduit is in fluidic communication with a medicament delivered by the second infusion connector.
  • the needle of an inserter protrudes through the second lumen 3008b, 3009b and the base hub 3424 prior to insertion into a patient.
  • the needle of the inserter is of sufficient circumference to collapse the flexible first lumen 3008a, 3009a of the delivery conduit 3008, 3009 around the second lumen 3008b, 3009b to allow the delivery conduit 3008, 3009 to pass through the skin to an appropriate delivery depth in the patient.
  • this configuration helps prevent the first tubular member from rolling up the second tubular member upon insertion (and/or snagging on the patient upon insertion).
  • the first tubular member may be flexible but still rigid enough to avoid rolling up the second tubular member during insertion.
  • the coaxial portion of the coaxial delivery conduit is at least partially disposed in the hub.
  • the hub comprises an aperture that extends from the port of the second docking station, through the hub, the aperture being configured to receive a delivery conduit (e.g., the second tubular member 3008b) from the second infusion connector.
  • the aperture is configured to allow the second tubular member (e.g., a piercing element of the second infusion connector) to extend through the infusion set and into patient.
  • coaxial delivery conduit is directly attached to the bottom surface of the infusion base and a portion of the coaxial conduit is not disposed within the hub.
  • a piercing element of the second infusion connector may terminate at the proximal portion of the second tubular member.
  • the piggy backing infusion set configuration comprises features that inhibit engagement of the second infusion connector to the first docking station.
  • the second docking station comprises features that inhibit engagement of the first infusion connector to the second docking station.
  • the features of the second infusion connector may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the second docking station corresponding to the pump chamber.
  • protrusion-shaped openings e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.
  • protruding features e.g., protrusions, tabs, lugs, detents
  • the features of the second docking station may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the second infusion connector corresponding to the pump chamber.
  • protrusion-shaped openings e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.
  • protruding features e.g., protrusions, tabs, lugs, detents
  • the features of the first infusion connector may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the first docking station corresponding to the pump chamber.
  • protrusion-shaped openings e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.
  • protruding features e.g., protrusions, tabs, lugs, detents
  • the features of the first docking station may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the first infusion connector corresponding to the pump chamber.
  • the depth of each lumen in the coaxial conduit can be varied for each cannula length and optimized for hormone infusion residual.
  • the infusion site connector 2632 (e.g., the first infusion site connector, as shown, or the second infusion site connector) comprises an ergonomic feature (e.g., a flared-out edge, a finger hold, a bulbous end, etc.). In some embodiments, the ergonomic feature allows the infusion site connector to be easily grasped and pulled from the infusion base.
  • the infusion site connector 2632 can have a thin section and a thick section, with the thick section being located proximal (towards) the tubing, and the thin section being proximal to base connection point.
  • this design feature similar to the ergonomic feature, allows the infusion site connector to be easily grasped by the finger tips and slid away from the infusion base.
  • Figure 12A shows an isometric view of a complete dual-medicament infusion set 2400 including the dual- medicament infusion site base 2401 assembled with the dual-medicament infusion site connectors.
  • the infusion set comprises a second infusion assembly comprising a second base and a second connector and a first infusion assembly comprising a first base and a first connector.
  • having the bases separate prevents needle pull in a system where both needles are fixed to a single base. In some embodiments, this feature increases comfort when the infusion set is placed on an area where movement, pulling, and discomfort can occur.
  • Figure 12B shows a cross-sectional view revealing the internal components of the dual-medicament infusion set 2400. In some embodiments, after connection of the second site connector 2432 and the first site connector 2533, to the second site base hub 2424 and the left site base hub 2525, respectively, two closed, independent, patent, and continuous fluid paths are created.
  • each fluid path terminates at 90 degree, beveled, hollow, piercing members 2442, 2542 (stainless steel needles).
  • each fluid path can begin in many types of connections to a fluid reservoir such as luer locks or custom cartridge connectors that eventually communicate with the lumen of the tubing 301 which is bonded together with a straight, beveled, hollow, stainless steel needle 2440, 2540 and an infusion site connector 2432, 2533, respectively.
  • the straight, beveled, hollow, stainless steel needle 2440, 2540 pierces a site base septum 2441, 2541 respectively, allowing fluid to be pushed through the 90 degree, beveled, hollow, stainless steel needle 2442, 2542 for delivery to the patient.
  • lettering (or other visual indicators) 2450, 2550 are present on the infusion set 2400.
  • the indicators 2442, 2542 provide convenience to a user, though, in some embodiments, mis- connection of components is still mechanically prevented.
  • the 90 degree, beveled, hollow, stainless steel needle 2442, 2542 is placed using a sub-assembly consisting of itself, a soft durometer tube 2451, 2551 and the site base septum 2441, 2541 which is then secured with a plug (not shown).
  • Figure 13A is an isometric view showing the second site base hub 2424 (shown in Figure 11B), as it would be used in the single-medicament configuration.
  • a second site base inserter 2443 can be attached as shown.
  • Figure 12B shows the second base hub 2424 after the second site base inserter 2443 has been removed.
  • the second site base inserter 2443 provides a handle for the application of the single-medicament infusion site base hub 2424. In some embodiments, after insertion, the second site base inserter 2443 is removed by activating the living hinge 2436 and sliding the right site base inserter 2443 out of the retention slot, 2430, to reveal the asymmetric post, 2431 that is now ready to accept a site connector 2432. Although only the half of the dual- medicament infusion site base 2401 (shown in Fig. 13B) is shown, the other half 2433 could also be used in a single-medicament configuration. In some embodiments, the other half 2433 could be attached using the same strategy, but with components having uniquely pairing features, hinges, etc.
  • Figure 14A shows an isometric view of the second site connector 2432 (shown in Figure 15), as it would be used in the single-medicament configuration, with the second site connector cover 2446.
  • Figure 14B shows the second site connector 2432 after the second site connector cover 2446 has been removed.
  • the second site connector cover 2446 protects the second site connector 2432 from exposure (e.g., to dirt, grime, debris, physical damage from bumps, etc.) and can be removed by activating the living hinge 2436, to release the retention clip 2435 and then sliding the second site connector 2432 out of the retention slot 2430 (shown in Figure 15B).
  • FIG. 15A shows an isometric view of the complete single-medicament infusion set 2400’ including the single-medicament infusion site base hub 2424 assembled with the single-medicament infusion site connector 2432.
  • Figure 15B shows a cross-sectional view revealing the internal components of the single-medicament infusion set 2400’.
  • a closed, independent, patent, and continuous fluid path is created after connection of the second site connector 2432 to the second site base hub 2424.
  • the closed fluid path terminates in a 90 degree piercing member, 2442 (e.g., a beveled, hollow, stainless steel needle).
  • the fluid path can begin in many types of connections to a fluid reservoir such as luer locks or custom cartridge connectors that eventually communicate with the lumen of the tubing 301.
  • the tubing 301 is bonded together with a straight piercing element 2440 (e.g., a beveled, hollow, stainless steel needle) and, in this depiction, the second site connector 2432.
  • a straight piercing element 2440 e.g., a beveled, hollow, stainless steel needle
  • the straight, beveled, hollow, stainless steel needle 2440 pierces the site base septum 2441, allowing fluid to be pushed through the 90 degree, beveled, hollow, stainless steel needle 2442, for delivery to the patient.
  • the first half of the infusion set (e.g., the left half) could also be used in a single- medicament configuration.
  • lettering or other visual indicators 2450, 2550 are present and provide convenience to a user. In some embodiments, beside the visual indicators, mis-connection of components is still mechanically prevented.
  • the 90 degree, beveled, hollow, stainless steel needle 2442 is placed using a sub-assembly consisting of itself, a soft durometer tube 2451 and the site base septum 2441 which is then secured with a plug (not shown).
  • Figures 16A-E show isometric views of embodiments of a dual- medicament infusion set.
  • Figure 16A with the right site base hub 2424, connected to a right site base cover 2444.
  • Figure 16B shows the first site base hub 2525 connected to a first site base cover 2545.
  • Figure 16C shows the second site connector 2432 connected to a second site connector cover 2446.
  • Figure 16D shows the first (left) site connector 2533 connected to a first (left) site connector cover 2547.
  • Figure 16E shows the dual-medicament infusion site base 2401 connected to a dual-medicament site base cover 2448.
  • an individual site connector when an individual site connector must be replaced, it can be disconnected from its site base and a site base cover can be temporarily connected to the site base thereby protecting it from exposure (as in A and B) until the site connector can be replaced.
  • a dual-medicament site base cover 2448 can be connected temporarily to both site bases to protect them from exposure until the site connectors can be replaced (as in E).
  • any individual site base when any individual site base must be replaced, it can be disconnected from its site connector and a site connector cover is temporarily connected to the site connector thereby protecting it from exposure (as in C and D) until the site base can be replaced.
  • a dual-medicament site connector cover can be connected temporarily to both site connectors to protect them from exposure until the site bases can be replaced (as in Figure 11A).
  • a single-medicament embodiment could operate in the same manner as the right site half of A and C or the left site half of B and D.
  • a single-medicament implementation of the infusion system that infuses only medicament A can use one of the two single-medicament infusion site connectors of the dual- medicament infusion site connectors.
  • the other single-medicament infusion site connector which is distinct from the single-medicament infusion site connector for medicament A, can be used for a single-medicament implementation of the infusion system that infuses only medicament B.
  • asymmetric features in the dual-medicament infusion site connectors such as any combination of asymmetric posts, asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways can be used to differentiate the single-medicament infusion site connector for medicament A from medicament B.
  • such features can also be used to ensure that a single-medicament implementation of the infusion system that infuses only medicament A uses only the medicament A chamber in the pump housing, and a single-medicament implementation of the infusion system that infuses only medicament B uses only the medicament B chamber in the pump housing.
  • the same molds used to manufacture the dual-medicament infusion site connectors will serve for the single-medicament infusion site connectors for a single-medicament implementation of the infusion system that infuses only medicament A or only medicament B.
  • the constituent components of the dual-medicament infusion site base, dual-medicament infusion site connectors, tubing, and needle connectors, which serve a dual-medicament implementation of the infusion system, can be used to serve one of two distinct single-medicament implementations of the infusion system, one for medicament A and one for medicament B.
  • software can be used to configure (automatically and/or manually) the infusion system to be configured either as a dual- medicament infusion system, as a single-medicament infusion system that uses only the medicament A chamber in the pump housing, or a single-medicament infusion system that uses only the medicament B chamber in the pump housing.
  • the dual-medicament infusion site connectors or appropriate single- medicament infusion site connectors can be chosen to match the particular configuration.
  • each site connector can be designed to connect to a site base by the action of at least one retention clip. Connection of a site connector to a site base allows piercing member (e.g., a straight, beveled, hollow, and/or stainless steel needle) to pierce a septum in the site base (as in Figures 12B, 12G, and 15B).
  • piercing member e.g., a straight, beveled, hollow, and/or stainless steel needle
  • the site base e.g., a delivery conduit of the site base
  • the site base comprises a piercing member (e.g., beveled, hollow, stainless steel needle), which can deliver the medicament to the delivery space.
  • this arrangement creates, for each medicament, a closed, independent, patent, and continuous fluid path from the medicament reservoir to the patient (e.g., for delivery transdermally, intradermally, subcutaneously, intramuscularly, intravenously, etc.).
  • each site base can be physically independent and can connect to or disconnect from a site connector repeatedly.
  • a single site base is provided (as shown in Figures 12C-12Jii).
  • piercing elements and/or delivery conduits can be overmolded, bonded, press-fitted, glued, solvent bonded, insert molded, or otherwise attached to the site base and/or the infusion connectors.
  • a piercing member may be sheathed with a soft durometer tube, which is in turn press-fit into the site base septum to create a sub- assembly outside the site base.
  • this sub-assembly can then be placed into a cavity in the site base (as shown in Figures 12B, 12G, and 15B) and a plug (not shown) can be used to hold the sub-assembly firmly in place while simultaneously ensuring a fluid seal.
  • the deliver conduit may be designed to protrude from the center or near the center of a site base (e.g., infusion base). In some embodiments, this arrangement increases the likelihood that the site base will remain adhered to the surface of the skin for the entirety of its intended use.
  • the site connectors and site bases can contain features such as lettering or other visual indicators to help prevent mis- connection of a site base or a site connector to incorrect site connectors or site bases.
  • lettering or other visual indicators colors, etc.
  • the lettering or other visual indicators can be raised and colored differently from the base material to enhance visibility.
  • the site connectors and the site bases can contain features such as asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways that prevent mis-connection of a site base or a site connector to incorrect site connectors or site bases.
  • each site connector can be designed to connect to a site base by the action of at least one retention clip that fits into at least one retention slot.
  • the retention clips and retention slots may be present on the medial or lateral (as in Figures 10A-12B) sides of the site connectors and site bases. If the retention clips and retention slots are present on the lateral side of one site connector and site base pair, and on the medial site of the other site connector and site base pair, convenience is afforded to the user by allowing for the same finger to activate the living hinges. In this case, mis-connection of the site connectors to incorrect site bases is still prevented by the presence of the asymmetric posts and asymmetric post receptacles.
  • a right site connector and a left site connector comprise the dual-medicament infusion site connectors, can be physically independent, and can contain features such as asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways that prevent mis- connection of the dual-medicament infusion site connectors to a dual-medicament infusion site base.
  • the site connectors and site bases are designed such that any site connector and site base pair from a multiple medicament configuration can be used individually in a single medicament configuration (as in Figures 17-19) such that the single medicament site connectors and site bases can be manufactured from the same tools as the multiple medicament site connectors and site bases.
  • the site connectors can be supplied with one or more site connector covers that may couple all of the site connectors, certain groups of the site connectors, or none of the site connectors such that each site connector can be supplied with its own site connector cover.
  • the site connector cover can be connected to and disconnected from the site connectors repeatedly and protects them from exposure (as in Figure 11A).
  • the site bases can be supplied with one or more site base covers that may couple all of the site bases, certain groups of the site bases, or none of the site bases such that each site base can be supplied with its own site base cover.
  • the site base cover can be connected to and disconnected from the site bases repeatedly and protects them from exposure.
  • the site base or site bases can be supplied with a site base inserter that connects to the site base or site bases in the same manner as the site connectors and provides a handle for the application of site base or site bases (as in Figures 10A-21Jii).
  • the handle provided by the site base inserter may be used to apply the site base manually or to load the site base(s) into an automated insertion device, such as a spring loaded inserter.
  • one or more site base inserters may couple all of the site bases, certain groups of the site bases, or none of the site bases such that each site base can be supplied with its own site base inserter.
  • the base 100 comprises multiple designated delivery conduits 130, 135 (e.g., needles, cannulae, etc.). While the needles 130, 135 shown in Figure 18C are of approximately the same length, the delivery members (e.g., needles, cannulae, etc.) can be inserted to the same or different depths under the skin by using different lengths of needles (as can delivery members of other configurations of infusion bases, as disclosed herein).
  • the delivery members e.g., needles, cannulae, etc.
  • the delivery members can be inserted to the same or different depths under the skin by using different lengths of needles (as can delivery members of other configurations of infusion bases, as disclosed herein).
  • the ratio between the delivery member lengths is at least about: 1:1, 1:1.5, 1:2, 1:5, 1:10, values in between the aforementioned values, and otherwise.
  • the delivery members can have different shapes and profiles.
  • medicaments can separately or together be delivered transdermally, intradermally, subcutaneously, intramuscularly, or intravenously using separate delivery members (e.g., needles or cannulas).
  • subcutaneous is used in several examples throughout this disclosure, the methods described herein are applicable to any of transdermal, intradermal, subcutaneous, intramuscular, or intravenous delivery, and the use of the term subcutaneous is used in an exemplary fashion.
  • the medicament(s) can be delivered to, for example, a surface of the skin with or without the use of a permeation enhancing agent (e.g., a solvent such as DMSO, azone, pyrrolidones, fatty acids, essential oils, terpenes, terpenoids, oxazolidinones, urea, or the like).
  • a permeation enhancing agent e.g., a solvent such as DMSO, azone, pyrrolidones, fatty acids, essential oils, terpenes, terpenoids, oxazolidinones, urea, or the like.
  • the medicament(s) can be delivered via a delivery member (e.g., a microneedle, etc.) that penetrates the skin by less than or equal to about 8 mm, about 6 mm, about 4 mm, about 2 mm, about 1 mm, or about 0.5 mm.
  • the drug is delivered by catheters 130, 135 which can be placed under into the skin using trocars.
  • cannula angles can be independently varied with respect to one another. For instance, in some embodiments, where the cannulas are at an angle of 0 ° with respect to each other, the needles that are aligned. In some embodiments, the cannulas are at angles with respect to one another that are more than about 0 °, about 5 °, about 10 °, about 15 °, about 20 °, about 30 °, or about 40 °.
  • the left side distribution connector 210 i.e., the first distribution connector
  • the right side distribution connector 220 i.e., the second distribution connector
  • This capacity to engage only certain features of corresponding infusion system parts helps maintain separate medicament fluid paths (because distribution connectors cannot be simply switched from one side to the other).
  • the infusion connectors 210, 220 comprise tabs 212, 222.
  • the tabs 212, 222 are textured (e.g., ribbed, knurled, abraded, etc.) to provide traction during depression or positioning of each of the distribution connectors 210, 220.
  • these pads allow single hand coupling and decoupling of the distribution connectors individually 210, 220 or as a set 200. This feature enables patients, even those with limited mobility and/or dexterity, to manipulate the connectors 210, 220 to engage and disengage them.
  • the pads click into place giving an auditory signal that the connectors are engaged. In some embodiments, visual verification of attachment is unnecessary.
  • the tabs 212, 222 comprise connection members 214, 224 (e.g., a flange, lip, groove, detent, etc.) that engage securing apertures 114 on the housing 105 to secure the distribution connectors 210, 220. These features help tightly seal the distribution connectors 210, 220 to the housing 105.
  • the tabs 212, 222 can be single- handedly be depressed to disengage the connection members 214, 224 and to release the distribution connectors 210, 220.
  • the base 100 comprises a projecting first fluid inlet 110 and a second fluid inlet 120.
  • the base 100 comprises an adhering surface 102 (adhesive tape, gel, etc.) configured to secure the infusion set to the skin of a patient.
  • the base 100 comprises a support surface 104 (e.g., a foam pad) that engages the housing 105 and provides a connection point to the adhering surface 102 (e.g., a tacky foam).
  • the adhering surface 102, support surface 104, and housing 105 have apertures configured to align and to allow the needles 130, 135 to pass through.
  • an inserter can be provided to properly align the base before it is deployed. The inserter can comprise a spring loading to quickly insert the needles 130, 135 into the skin, allowing the patient (or doctor) to direct the location of the base.
  • the distribution connectors 210, 220 are configured to receive needles 216, 226.
  • the needles 216, 226 can be heat bonded (or heat staked, insert molded, otherwise glued, welded, or affixed) in place within fluid conduit apertures 250, 260 of the distribution connectors 210, 220 during fabrication of the distribution connectors 210, 220.
  • the needles 216, 226 are removable and/or replaceable.
  • the first needle 216 and the second needle 226 of the distribution connectors 210, 220 are configured to pierce a first septum 112 and a second septum 122 residing within the first fluid inlet 110 and the second fluid inlet 120 of the housing 105, respectively.
  • These septa 112, 122 can be configured to prevent unwanted leaking of medicaments when connecting and disconnecting the distribution connectors 210, 220 via the first fluid inlet 110 and the second fluid inlet 120.
  • the septa 112, 122 comprise entrance slits that allow a needle to insert through the septa without friction. This feature minimizes buckling and back pressure in the fluid conduit.
  • Buckling and/or back pressure can cause uneven delivery of the medicaments by causing bolus deposits to form within the connector (in, for instance the conical inlet 111) or by creating void spaces within a channel.
  • securing rings 116, 126 can be used secure the septa 112, 122 in place to avoid needle or channel buckling.
  • the rings are heat staked or ultrasonically welded into the base 100.
  • rings are not used and the fluid inlets are melted or otherwise affixed in place.
  • the rings are replaceable.
  • the first distribution connector 210 and the second distribution connector 220 can be removed from the housing separately.
  • a user may wish to replace one of the distribution connectors and to leave the other in place.
  • the distribution connectors 210, 220 when replacing a faulty distribution connector, it can only be replaced by the same type of distribution connector (e.g., a first distribution connector can only be replaced by a replacement first distribution connector and not a replacement distribution connector that has the shape of the second distribution connector).
  • the first distribution connector 210 is configured to engage the second distribution connector 220 via an engaging fastener 218 (e.g., a projection, dovetail, tongue, etc.) located on the first distribution connector 210 that interacts with a fastener aperture 228 (e.g., a groove) on the second distribution connector 220.
  • an engaging fastener 218 e.g., a projection, dovetail, tongue, etc.
  • a fastener aperture 228 e.g., a groove
  • This design element further aids in preventing the misplacement of distribution connectors during replacement (because two “second” distribution connectors cannot link together and two “first” distribution connectors could physically block each other from engagement on the housing via the dovetails).
  • these features are not present and other features of the connection/housing assembly ensure proper coupling.
  • a groove and tongue can be included on an individual distribution connector. These can interact with corresponding features of an adjacent connector to provide asymmetric connectors that can only be used together in the desired specified way (thereby limiting cross-channeling).
  • the housing can comprise design elements that allow only desired interactions with infusion connectors having complementary elements.
  • the housing 105 comprises a first guide member 150 and a second guide member 160.
  • the first guide member 150 engages a corresponding first slide aperture 230 of the first distribution connector 210 and the second slide member 160 engages a corresponding second slide aperture 240 of the second distribution connector 220.
  • these members are not present and other features of the connection/housing assembly ensure proper coupling.
  • the guide member/slide aperture configuration allows only the first distribution connector 210 to interact with the first fluid path and only the second distribution connector 220 to interact with the second fluid path. This is true even where the engaging fastener 218 and fastener aperture 228 are not present.
  • the guide member/slide aperture configuration is configured in such a way as to prevent the misplacement of distribution connectors during replacement (because two “second” distribution connectors cannot link to the housing simultaneously – the slide aperture would be facing away from the slide member).
  • this feature of the infusion system also ensures the fluid paths can be maintained and chances for cross channeling minimized.
  • the infusion pump may be equipped with a cartridge detection hardware-software system that would detect, separately, whenever each cartridge is fully loaded and secured in its corresponding pump chamber.
  • the cartridge detection system can, when functioning in conjunction with the design described herein, effectively and conclusively inform the infusion pump system of which specific medicaments are available for potential infusion.
  • the availability status of each medicament for potential infusion at any point in time would also allow the infusion pump system to set its mode of operation accordingly.
  • the detection of both cartridges being in place would allow the infusion pump system to operate in dual-infusion mode, whereas the detection of one cartridge being in place but not the other would lead the infusion pump system to operate in a single-infusion mode that is specific to the medicament that corresponds to the cartridge that is detected to be in place.
  • this detection capability would be determined autonomously in real time, including when a cartridge is in place or out of place transiently or temporarily.
  • the infusion pump may also be equipped with a delivery occlusion hardware-software detection system that would detect, separately, whenever the fluid-delivery path associated with each cartridge is impeded or obstructed anywhere from the cartridge, all the way through the corresponding tubing, and out to the distal end of the corresponding site base.
  • a delivery occlusion hardware-software detection system that would detect, separately, whenever the fluid-delivery path associated with each cartridge is impeded or obstructed anywhere from the cartridge, all the way through the corresponding tubing, and out to the distal end of the corresponding site base.
  • the occlusion detection system would, when functioning in conjunction with the design described herein, effectively and conclusively inform the infusion pump system of which specific medicaments have a patent fluid-delivery path.
  • the infusion pump may at any point in time conclusively determines which medicament is possible to deliver to the user.
  • the infusion pump could then autonomously set its mode of operation, as per the detection of which of the cartridges are in place along with the patency of their corresponding fluid- delivery paths.
  • a dual-chamber pump that autonomously controls blood glucose levels by delivering insulin or an insulin analog, as well as a counter-regulatory agent (e.g.
  • glucagon, a glucagon analog, or dextrose when functioning in conjunction with the design described here, would practically allow the infusion pump system to be prescribed in a particular configuration to deliver only insulin, or only the counter-regulatory agent, or both.
  • such an implementation would also allow the dual- chamber infusion pump system to autonomously switch its mode of operation in real time whenever either delivery channel becomes unavailable for delivery (whether informed by cartridge detection, occlusion detection, or both), including in cases where channel availability may alternate in real time.
  • the cartridge and occlusion detection methods could be realized through a variety of hardware and software implementations, including, but not limited to, techniques that rely on magnetic field or electrical signal feedback in the case of cartridge detection, or techniques that rely on back pressure detection or flow sensor technology in the case of occlusion detection, to mention but a few.
  • the features described in the context of one base, connector, housing, inlet connector, inlet connector cover, medicament reservoir, or pump assembly can be mixed and matched and used in different combinations on other bases, connectors, housings, inlet connectors, inlet connector covers, collars, medicament reservoirs, or pump assemblies. For instance, any feature described above to prevent mischanneling can be deleted from or added to other embodiments.
  • Redundant features can be added or deleted from the components of the medicament delivery systems.
  • the examples shown here are meant to be representative of a general approach to the design of an infusion system for multiple medicaments and various connectors, tubes, and cartridges to ensure proper channeling of each medicament to the patient.
  • the geometric shapes, sizes, orientations, locations, and number of tabs, protrusions, and features, as well as the corresponding cavities, grooves, keyways, or slots are merely meant to be examples of a much greater abundance of variations on the particular examples shown here.
  • the degrees of separation between the tabs, protrusions, and features on the cap connectors and on the corresponding cavities, grooves, keyways, or slots in the pump housing, or the degrees of separation between the tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector shown here can be generalized to be placed closer together or farther apart than in the examples shown here.
  • the number of tabs, protrusions, and features on the cap connectors and on the corresponding cavities, grooves, keyways, or slots in the pump housing, or the number of tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector designs shown here can be generalized to one, two, three or more such features, which might have different sizes, shapes, orientations, and locations from the examples shown here.
  • the locations of the tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector designs shown here need not be limited to the neck or head (or crown) regions of the cartridge.
  • the point of engagement between the pre-fitted collar assembly and the cap connector could alternatively occur elsewhere on the body of the cartridge, or extend over the entire length of the cartridge.
  • the tabs, protrusions, and features on the pre-fitted collar assemblies described here could instead appear directly on the surface of the cartridge (such as in the case of an injection molded cartridge), which is either pre-filled with medicament or not pre-filled with medicament.
  • the cartridges described here can either be pre- filled with medicament or not pre-filled with medicament before or after the pre-fitted collar assemblies described here are installed onto the cartridge. In the case of the latter, such cartridges can be filled with medicament sometime after the manufacturing process, including at the point of care.
  • the cap connector might not contain a recessed needle, but rather might couple with said cartridge using a standard luer lock or other mechanism, in which the medicament flows directly from the cartridge into the tubing without first passing through a needle.
  • the tabs, protrusions, and features on the pre-fitted collar assemblies described here would still appear on the surface of the cap connector.
  • mischanneling of medicaments can still be avoided if one cartridge is prefilled with one medicament and a second cartridge is filled at the point of care with a different medicament.
  • the designs described here can prevent medicament mischanneling.
  • the features and components described above are applicable to reusable injection pens (e.g., insulin pens, etc.).
  • each collar, cap, input connector, etc. could be applied to prevent incorrect dosing of drugs delivered by injection pens.
  • one unique cartridge, having a first set of unique features as described above could be used to deliver long-acting insulin to a patient via a mated injection pen.
  • Another unique cartridge, with a second set of unique features as described above could be used to deliver fast-acting or ultra-rapid insulin analogs to a patient via a different mated injection pen.
  • these features can be used to differentiate between more and less concentrated insulin analogs (e.g. U100, U200, or U500 insulin analogs).
  • the medicament described above for any embodiment can include any suitable compound or drug for treating, regulating, controlling or addressing one or more conditions of the patient. While diabetes mellitus is a target, other conditions can be addressed as well (e.g., pancreatic misfunction).
  • the medicament can include for example a regulating agent, such as insulin, for regulating the blood glucose levels in the patient and/or a counter-regulatory agent, such as glucose or glucagon, for more effective blood glucose regulation in certain circumstances.
  • a regulating agent such as insulin
  • a counter-regulatory agent such as glucose or glucagon
  • Other type of agents can be used as well.
  • an infusion system for multiple medicaments involving various needle sites, connectors, tubes, and cartridges that ensure proper channeling of each medicament to the patient is provided.
  • the infusion system comprises an infusion pump.
  • the infusion system comprises an infusion pump with two or more pump chambers.
  • the infusion system comprises cartridges that can be filled at the point of care with different medicaments (or may be pre-filled with different medicaments).
  • the infusion system comprises connectors and tubing that connect the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments.
  • each type of cartridge for each type of medicament has unique differentiating sizes, shapes, and/or geometrical features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge) that allow for unique coupling with a type of connector that itself has unique differentiating features that engage corresponding features in the pump housing and only allow for insertion of the proper cartridge into the proper pump chamber within the infusion pump.
  • the systems described above can be used for the delivery of single medicaments, or combinations of medicaments.
  • the infusion set can be used to deliver agent A (e.g., insulin), while the features of that infusion set would be incompatible with the medicament reservoir for agent B (e.g., glucagon).
  • agent A e.g., insulin
  • the infusion set can be used to deliver agent B, while the features of that infusion set would be incompatible with the medicament reservoir for agent A.
  • dual medicaments can be delivered without mischanneling (e.g., bi-hormonal delivery, dual drug delivery, etc.).
  • configurations for the delivery of a plurality of medicaments e.g., two, three, four, or more
  • mischanneling can be provided.
  • methods of making the infusion systems disclosed herein are provided.
  • various needle sites, connectors, tubes, and cartridges that ensure proper channeling of each medicament to the patient are assembled.
  • the method comprises assembling an infusion system with an infusion pump.
  • the method comprises assembling an infusion system with a pump having two or more pump chambers.
  • the method comprises assembling an infusion system with connectors and tubing that connect the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments.
  • each type of cartridge for each type of medicament is assembled to have unique differentiating sizes, shapes, and/or geometrical features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge) that allow for unique coupling with a type of connector that itself has unique differentiating features that engage corresponding features in the pump housing and only allow for insertion of the proper cartridge into the proper pump chamber within the infusion pump.
  • a pump housing is prepared by connecting a bezel to a lower portion of the pump.
  • a display screen is connected to the bezel.
  • one or more of the o-rings, lead screws, drive nuts, motors, power sources, and gear assemblies are added to the pump housing.
  • the body of a connector is affixed to a knob.
  • a membrane is placed between the knob and the body.
  • a needle is affixed to the body.
  • a fluid conduit is affixed to the connector.
  • a fluid conduit is affixed to an infusion site connector.
  • the first and/or second infusion connector is coupled to a lumen assembly (e.g., a multi-channel lumen assembly).
  • the first and/or second cartridge connector is affixed to the lumen assembly.
  • any of the features of the cartridge connectors, pumps, and/or cartridges disclosed herein e.g., retention lugs (shape, size, and position), detents (shape, size, and position), skirts (length and diameter), threading (e.g., different directional, such as clockwise counter clockwise), cartridge connectors (shape, size, and position), corresponding receiving portions on the pump receptacles, etc.
  • retention lugs shape, size, and position
  • detents shape, size, and position
  • skirts length and diameter
  • threading e.g., different directional, such as clockwise counter clockwise
  • cartridge connectors shape, size, and position
  • cartridge connectors e.g., retention lugs and detents
  • the corresponding pump features described above lug and detent tracks
  • the cartridge connectors, pumps, and/or cartridges disclosed herein could lack one or more features disclosed herein.
  • Any terms generally associated with circles, such as “radius” or “radial” or “diameter” or “circumference” or “circumferential” or any derivatives or similar types of terms are intended to be used to designate any corresponding structure in any type of geometry, not just circular structures.
  • radial as applied to another geometric structure should be understood to refer to a direction or distance between a location corresponding to a general geometric center of such structure to a perimeter of such structure; “diameter” as applied to another geometric structure should be understood to refer to a cross sectional width of such structure; and “circumference” as applied to another geometric structure should be understood to refer to a perimeter region. None in this specification or drawings should be interpreted to limit these terms to only circles or circular structures. Likewise, any terms generally associated with polygons, such as “one side,” “another side,” or any derivatives or similar types of terms are intended to be used to designate any corresponding structure in any type of geometry, not just polygonal structures.
  • a circle, an ovals, a curved structure, or a structure without vertices may have a feature that is closer to one side than another side of the circle.
  • the section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. Features disclosed under one heading (such as a connector) can be used in combination with features disclosed under a different heading (an infusion set). Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. It should be noted that the use of particular terminology when describing certain features or aspects of the disclosure should not be taken to imply that the terminology is being re-defined herein to be restricted to include any specific characteristics of the features or aspects of the disclosure with which that terminology is associated.

Abstract

Certain embodiments provide multi-medicament or single medicament infusion systems (and components thereof) for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations. Certain embodiments provide an infusion set. The infusion set may comprise an infusion base and one or more infusion connectors. The infusion set may comprise a coaxial medicament delivery conduit. Certain embodiments provide cartridge connectors comprising fittings.

Description

AMBULATORY DEVICE AND COMPONENTS THEREOF CROSS REFERENCE TO RELATED APPLICATIONS [0001] The present application claims the benefit of priority to U.S. Provisional Patent Application No. 63/238670, filed August 30, 2021, and U.S. Provisional Patent Application No. 63/139210, filed January 19, 2021. The disclosures of each of the foregoing applications are hereby incorporated by reference in their entireties. Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference under 37 CFR 1.57. Field of the Invention [0002] The disclosure relates generally to the field of medicament infusion systems (including systems configured to delivery multiple medicaments to a subject), components thereof (e.g., pump systems, cartridge connectors, cartridges, connector sets, multi-channel lumen assemblies, infusion sets, combinations of any of the foregoing, etc.), methods of making each of the foregoing, and methods of using each of the foregoing. BACKGROUND [0003] Sustained delivery, pump driven medicament injection devices generally include a delivery cannula mounted in a subcutaneous manner through the skin of the patient at an infusion site. The pump draws medicine from a reservoir and delivers it to the patient via the cannula. The injection device typically includes a channel that transmits a medicament from an inlet port to the delivery cannula which results in delivery to the subcutaneous tissue layer where the delivery cannula terminates. Some infusion devices are configured to deliver one medicament to a patient while others are configured to deliver multiple medicaments to patient. SUMMARY [0004] Some embodiments herein provide medicament infusion systems (including systems configured to delivery multiple medicaments to a subject), components thereof (e.g., pump systems, cartridge connectors, cartridges, connector sets, multi-channel lumen assemblies, infusion sets, etc.), combinations of any one or more components, methods of making each of the foregoing, and methods of using each of the foregoing. In several embodiments, one or more components disclosed herein engage and/or interact with components with corresponding (e.g., mating, paired, and/or matched) features. In several embodiments, these components with corresponding features engage some components but not others (e.g., blocking interaction between components that are not matched). [0005] Some embodiments pertain to an infusion pump for delivering medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In some embodiments, the infusion pump comprises a pump housing. In some embodiments, the pump housing comprises a first receptacle port configured to engage a first cartridge connector. In some embodiments, the pump housing comprises a second receptacle port configured to engage a second cartridge connector. In some embodiments, the pump housing comprises a first medicament cartridge receptacle extending from the first receptacle port longitudinally along a first side of the infusion pump to a first cartridge receptacle aperture. In some embodiments, the pump housing comprises a second medicament cartridge receptacle extending from the second receptacle port longitudinally along a second side of the infusion pump to a second cartridge receptacle aperture. In some embodiments, the pump comprises an internal area. In some embodiments, the internal area comprises a power source. In some embodiments, the power source is located between the first medicament cartridge receptacle and the second medicament cartridge receptacle. In some embodiments, the internal area comprises a first motor in electronic communication with the power source. In some embodiments, the internal area comprises a second motor in electronic communication with the power source. In some embodiments, the internal area comprises a first stacked gear assembly. In some embodiments, the internal area comprises a second stacked gear assembly. In some embodiments, the internal area comprises a first lead screw. In some embodiments, the internal area comprises a second lead screw. In some embodiments, the power source is located between the first lead screw and the second lead screw. In some embodiments, the first motor comprises a first pinion gear, the first pinion gear being a member of the first stacked gear assembly. In some embodiments, the second motor (where present) comprises a second pinion gear (where present), the second pinion gear being a member of the second stacked gear assembly (where present). In some embodiments, the first gear assembly extends laterally toward the first side of the infusion pump. In some embodiments, the second gear assembly extends laterally toward the second side of the infusion pump. In some embodiments, the first lead screw is in rotational communication with the first pinion gear through the first gear assembly. In some embodiments, the second lead screw is in rotational communication with the second pinion gear through the second gear assembly. In some embodiments, the pump comprises a first drive nut having a length extending longitudinally along the pump housing. In some embodiments, the first drive nut is configured to travel into the first medicament cartridge receptacle via the first aperture. In some embodiments, the first drive nut is in communication with the first lead screw and is configured to urge forward or backward in response to a first direction of rotation and a second direction of rotation, respectively, of the first lead screw. In some embodiments, the pump comprises a second drive nut having a length extending longitudinally along the pump housing. In some embodiments, the second drive nut is configured to travel into the second medicament cartridge receptacle via the second aperture. In some embodiments, the second drive nut is in communication with the second lead screw and is configured to urge forward or backward in response to a first direction of rotation and a second direction of rotation, respectively, of the second lead screw. In some embodiments, the first receptacle port has one or more recognition features configured to engage with corresponding recognition features of the first cartridge connector. In some embodiments, the second receptacle port has one or more recognition features configured to engage with corresponding recognition features of the second cartridge connector. In some embodiments, the recognition features of the first receptacle port are different from the recognition features of the second receptacle port. In some embodiments, the first receptacle port is configured to not allow engagement of the second cartridge connector and the second receptacle port is configured to not allow engagement of the first cartridge connector. In some embodiments, the pump comprises a first seal and/or a second seal. In some embodiments, the first seal provides a water-resistant barrier between the internal area of the infusion pump and the first medicament cartridge receptacle. In some embodiments, the second seal provides a water-resistant barrier between the internal area of the infusion pump and the second medicament cartridge receptacle. In some embodiments, the first seal is a first O-ring that circumferentially surrounds at least a portion of the first drive nut. In some embodiments, the second seal is a second O-ring that circumferentially surrounds at least a portion of the second drive nut. In some embodiments, the pump housing comprises a first saddle. In some embodiments, the pump housing comprises a second saddle. In some embodiments, the first saddle is configured to retain the first O-ring. In some embodiments, the second saddle is configured to retain the second O- ring. In some embodiments, the first saddle is positioned adjacent to the first cartridge receptacle aperture. In some embodiments, the second saddle is positioned adjacent to the second cartridge receptacle aperture. In some embodiments, the first receptacle port comprises a snap arm recess extending longitudinally within the first medicament cartridge receptacle, the snap arm recess of the first medicament cartridge receptacle being configured to receive a snap arm of the first cartridge connector as the snap arm expands over a first medicament cartridge cap during engagement of a first medicament cartridge while the first medicament cartridge is housed in (e.g., positioned in, residing in, etc.) the first medicament cartridge receptacle. In some embodiments, the second receptacle port comprises a snap arm recess extending longitudinally within the second medicament cartridge receptacle, the snap arm recess of the second medicament cartridge receptacle being configured to receive a snap arm of the second cartridge connector as the snap arm expands over a second medicament cartridge cap during engagement of a second medicament cartridge while the second medicament cartridge is housed in (e.g., positioned in, residing in, etc.) the second medicament cartridge receptacle. In some embodiments, the snap arm recess of the first receptacle port is configured not to receive the snap arm of the second cartridge connector. In some embodiments, the first receptacle port comprises lug opening and a radially extending lug track configured to receive a lug of the first cartridge connector as the first cartridge connector is inserted into the first receptacle port and turned into place. In some embodiments, the second receptacle port comprises lug opening and a radially extending lug track configured to receive a lug of the second cartridge connector as the second cartridge connector is inserted into the second receptacle port and turned into place. In some embodiments, the first receptacle port comprises detent opening and a detent track. In some embodiments, the detent track comprises a detent cam with a shallow first transition and a steep second transition. In some embodiments, the detent opening and detent track are configured to receive a detent of the first cartridge connector as the first cartridge connector is inserted into the first receptacle port and turned into place. In some embodiments, the shallow first transition is configured to allow the detent of the first cartridge connector to be turned into place within the infusion pump with less force than is required to remove the first cartridge connector from the first receptacle port along the direction of the steep second transition. In some embodiments, the second receptacle port comprises detent opening and a detent track. In some embodiments, the detent track comprises a detent cam with a shallow first transition and a steep second transition. In some embodiments, the detent opening and detent track are configured to receive a detent of the second cartridge connector as the second cartridge connector is inserted into the second receptacle port and turned into place. In some embodiments, the shallow first transition is configured to allow the detent of the second cartridge connector to be turned into place within the infusion pump with less force than is required to remove the second cartridge connector from the second receptacle port along the direction of the steep second transition. In some embodiments, the cartridge receptacle is configured to not be sealed from the external environment (and/or are configured to allow pressure equilibrate between the atmosphere and the receptacle). For example, in some embodiments, a cartridge connector does not provide an airtight seal when engaged to the infusion pump (e.g., it does not provide an air tight seal between the receptacle and the atmosphere around the infusion pump). In some embodiments, the cartridge chamber in the infusion pump may allow air and water to pass freely around the drug cartridges. [0006] Several embodiments pertain to an infusion site base for delivering multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the infusion site base comprises a hub. In some embodiments, the hub comprises an upper surface, a bottom surface, and a side surface. In several embodiments, the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it to the hub via the coupling feature of the first docking station. In several embodiments, the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it to the hub via the coupling feature of the second docking station. In several embodiments, the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and configured to adhere the infusion site base to skin the patient. In several embodiments, the infusion site base comprises a coaxial delivery conduit extending distally from the hub and passed the adhesive (and/or through the adhesive). In several embodiments, the coaxial delivery conduit comprises a first tubular member having a first lumen and a second tubular member comprising a second lumen. In several embodiments, the second tubular member is disposed at least partially within the first lumen of the first tubular member of the coaxial delivery conduit. In several embodiments, the first lumen of the first tubular member is in fluidic communication with the port of the first docking station. In several embodiments, the second lumen of the second tubular member is in fluidic communication with the port of the second docking station. [0007] In several embodiments, the first and second docking stations may be present on the same or different surfaces of the hub. For example, in several embodiments, the first docking station is located on or at a side surface of the hub. In several embodiments, the second docking station is located on an upper surface of the hub. In several embodiments, the first lumen of the first tubular member is not in fluidic communication with the second lumen of the second tubular member. In several embodiments, the first tubular member is flexible and/or the second tubular member is flexible. In several embodiments, the first tubular member is a cannula and/or the second tubular member is a cannula. In several embodiments, the first tubular member is rigid and/or the second tubular member is rigid. In several embodiments, the first tubular member is a needle and/or the second tubular member is a needle. In several embodiments, the second tubular member extends distally from the hub to a distance farther from the hub than a distance to which the first tubular member extends. In several embodiments, the second tubular member extends distally from the hub to a distance from the hub equal to a distance to which the first tubular member extends. In several embodiments, the second tubular member extends to a distance from the hub that is equal to or less than a distance to which the first tubular member extends. In several embodiments, the coaxial delivery conduit is at least partially disposed in the hub. In several embodiments, at least a portion of the coaxial delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient. [0008] Several embodiments pertain to an infusion site base for delivering multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the infusion site base comprises a hub having an upper surface, a bottom surface, and a side surface. In several embodiments, the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it via the coupling feature of the first docking station. In several embodiments, the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it via the coupling feature of the second docking station. In several embodiments, the hub comprises an aperture that extends from the port of the second docking station, through the hub, the aperture being configured to receive a delivery conduit from the second infusion connector. In several embodiments, the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and is configured to adhere the infusion site base to skin the patient. In several embodiments, the infusion site base comprises a delivery conduit extending distally from the hub and passed the adhesive. In several embodiments, the delivery conduit comprising a first tubular member having a first lumen, the first lumen of the delivery conduit being in fluidic communication with the port of the first docking station via the fluid passage of the hub. In several embodiments, at least a portion of the delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient. [0009] In several embodiments, the first tubular member is flexible. In several embodiments, first tubular member is a cannula. In several embodiments, the first tubular member is rigid. In several embodiments, the first tubular member is a needle. [0010] In several embodiments, the aperture is configured to allow a piercing element of the second infusion connector to extend through the infusion set and into patient. In several embodiments, the aperture of the hub leads to and/or is in fluidic communication with an opening (e.g., aperture, mouth, etc.) of the first tubular member. In several embodiments, the aperture is configured to allow the delivery conduit from the second infusion connector to extend through the infusion set and into patient. In several embodiments, when the second infusion connector is engaged with the hub, the delivery conduit from the second infusion connector provides a second tubular member disposed at least partially within the first lumen of the first tubular member, thereby providing a coaxial delivery conduit. [0011] Several embodiments pertain to an infusion site base for delivering multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the infusion site base comprises a hub having an upper surface, a bottom surface, and a side surface. In several embodiments, the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple to it to the hub via the coupling feature of the first docking station. In several embodiments, the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple to it to the hub via the coupling feature of the second docking station. In several embodiments, the infusion site base comprises an adhesive (e.g., a tacky surface, an adhesive pad, etc.) located below the hub and configured to adhere the infusion site base to skin the patient. In several embodiments, the infusion site base comprises a dual lumen delivery conduit extending distally from the hub and passed the adhesive. In several embodiments, the dual lumen delivery conduit comprises a first lumen and a second lumen. In several embodiments, the first lumen is in fluidic communication with the port of the first docking station. In several embodiments, the second lumen is in fluidic communication with the port of the second docking station. [0012] In several embodiments, the first docking station is located on the side surface of the hub and wherein the second docking station is located on an upper surface of the hub. In several embodiments, the first lumen is not in fluidic communication with the second lumen. In several embodiments, the dual lumen delivery conduit is flexible. In several embodiments, at least a portion of the dual lumen delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient. In several embodiments, the second docking station is located on the upper surface of the hub. In several embodiments, the first docking station comprises features that inhibit engagement of the second infusion connector to the first docking station. In several embodiments, the second docking station comprises features that inhibit engagement of the first infusion connector to the second docking station. [0013] Several embodiments pertain to a system for delivery of multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. For instance, in several embodiments, the system may comprise an infusion site base in combination with one or more of the components disclosed above or elsewhere herein. In several embodiments, the system comprises the infusion site base as disclosed above or elsewhere herein, the first infusion connector, and the second infusion connector. In several embodiments, the second infusion connector comprises a piercing element. In several embodiments, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through a port of the hub of the infusion site base. For example, the port of the second docking station (and/or of the first docking station) may comprise a pierceable element (e.g., a septum, an elastomeric seal, etc.). In several embodiments, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub of the infusion site base. In several embodiments, the piercing element of the second infusion connector is a needle. In several embodiments, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub and into a delivery conduit of the infusion site base (e.g., a first tubular fluid conduit). Alternatively, in several embodiments, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub and is located at a position laterally disposed from the first tubular fluid conduit. [0014] Several embodiments pertain to a system for delivery of multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the system comprises the infusion site base as disclosed above or elsewhere herein, the first infusion connector, and the second infusion connector. In several embodiments, the system further comprising a multi-channel lumen assembly, wherein the multi-channel lumen assembly comprises the first infusion connector and second infusion connector, the multi- channel lumen assembly comprising a first fluid conduit in fluidic communication with the first infusion connector and a second fluid conduit in fluidic communication with a second infusion connector. In several embodiments, the system further comprising a first reservoir connector in fluidic communication with the first infusion connector via the first fluid conduit of the multi-channel lumen assembly. In several embodiments, the system further comprises a second reservoir connector in fluidic communication with the second infusion connector via the second fluid conduit of the multi-channel lumen assembly. In several embodiments, when the first infusion connector is engaged to the first docking station and the second infusion connector is engaged to the second docking station, the second fluid conduit of the multi-channel lumen assembly is disposed over the first fluid conduit of the multi-channel lumen assembly. [0015] Several embodiments pertain to an infusion set for delivering multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the infusion set comprises an infusion site base. In several embodiments, the infusion set comprises one or more of a first infusion connector, a second infusion connector, and an infusion site base. In several embodiments, the infusion set comprises one or more of a first infusion connector, a second infusion connector, and a multi-channel lumen assembly. In several embodiments, the infusion set comprises one or more of a first infusion connector, a second infusion connector, a multi-channel lumen assembly, and an infusion site base. In several embodiments, the infusion set comprises an adhesive portion configured to adhere the infusion set to skin the patient. In several embodiments, the infusion set comprises a hub having a top surface and a bottom surface, the bottom surface of the hub being proximal to the adhesive portion of the infusion set and the top surface being distal to the adhesive portion of the infusion set. In several embodiments, the hub comprises a first docking station comprising a coupling feature and a port, the first docking station being configured to receive the first infusion connector and to couple to it via the coupling feature of the first docking station. In several embodiments, the hub comprises a second docking station comprising a coupling feature and a port, the second docking station being configured to receive the second infusion connector and to couple to it via the coupling feature of the second docking station. In several embodiments, the infusion set comprises a coaxial delivery conduit extending distally from the hub, the coaxial delivery conduit comprising a first tubular member having a first lumen and a second tubular member comprising a second lumen, the second tubular member being disposed at least partially within the first lumen of the first tubular member. In several embodiments, the first lumen of the first tubular member is in fluidic communication with the port of the first docking station. In several embodiments, the coaxial delivery conduit extends distally from the adhesive portion and, when the infusion set is adhered to a skin of the patient, is configured to extend below a surface of the skin of the patient. [0016] Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the first infusion connector comprises a first piercing member extending from a body of the first infusion connector infusion, the first piercing member having a lumen configured receive and to allow flow of a first medicament through the first infusion connector. In several embodiments, the piercing member extends axially (e.g., with respect to the fluid conduit) from the body of first infusion connecter. In several embodiments, the hub comprises a side surface extending between the upper surface and lower surface, the side surface comprising the first docking station. In several embodiments, upon coupling of the first infusion to the first docking station, the first piercing member extends through the port of the first docking station to provide fluidic communication between the lumen of the first piercing member and first lumen of the coaxial delivery conduit. In several embodiments, the port of the first docking station comprises a first septum configured to be pierced by the first piercing member upon connection between the first infusion connector to the infusion set. In several embodiments, the second infusion connector comprises a second piercing member extending from a body of the second infusion connector infusion, the second piercing member having a lumen configured receive and to allow flow of a second medicament through the second infusion connector. In several embodiments, the piercing member extends radially (e.g., with respect to the fluid conduit) from the body of second infusion connecter. In several embodiments, the port of the second docking station comprises a second septum configured to be pierced by the second piercing member upon connection between the second infusion connector to the infusion set. In several embodiments, the upper surface of the hub comprises the second docking station. In several embodiments, upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide fluidic communication between the lumen of the second piercing member and the second lumen of the coaxial delivery conduit. In several embodiments, the upper surface of the hub comprises the second docking station. In several embodiments, upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station. In several embodiments, upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide the lumen of the second piercing member and the second lumen of the coaxial delivery conduit. [0017] Several embodiments pertain to a cartridge connector (and/or to a set of cartridge connectors). Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the cartridge connector comprises a knob. In several embodiments, the knob comprises a surface portion having an upper side, a lower side, and a perimeter. In several embodiments, the knob comprises an upper knob portion extending distally from the upper side of the surface portion of the knob, the upper knob portion comprising an outlet port and an outlet fitting, the outlet fitting being circumferentially disposed around the outlet port, the outlet fitting being configured to engage a corresponding fitting of a fluid conduit of an infusion set such that, when the fitting of the fluid conduit is engaged to the outlet fitting, the cartridge connector and the fluid conduit of the infusion set are in fluidic communication. In several embodiments, the connector comprises a body extending distally from the lower side surface of the knob. In several embodiments, the body comprises a needle, a lower surface portion extending circumferentially from the needle, and a shroud extending axially away from the lower surface portion of the body and the lower side surface of the knob, the shroud being configured to engage a cap of a medicament cartridge when the medicament cartridge is inserted into the cartridge connector. In several embodiments, the lower surface portion of the body is located within the shroud. In several embodiments, the needle extends axially from the lower surface portion within the shroud and away from the lower surface portion of the body, the needle being configured to contact a medicament within the medicament cartridge when the medicament cartridge is inserted into the cartridge connector. [0018] In several embodiments, the upper knob portion comprises a length of fluid conduit extending distally from the surface portion and terminating at the outlet port and an outlet fitting of the upper knob portion. In several embodiments, the upper knob portion comprises a threaded shroud configured to engage the corresponding fitting of the fluid conduit of the infusion set. In several embodiments, the outlet fitting of the of the upper knob portion comprises a male receiving region. In several embodiments, the male receiving region is a male luer. In several embodiments, the male luer comprises an ISO 594- compliant luer taper. In several embodiments, the fitting of the fluid conduit of the infusion set is a female luer connector. In several embodiments, the surface portion of the knob extends outward from the upper knob portion. In several embodiments, the upper knob portion extends distally from the upper side surface portion of the knob at a position that is offset from a geometric center of the surface portion of the of the knob such that the upper knob portion is closer to one side of the perimeter of the surface portion than another side. [0019] In several embodiments, the perimeter of the surface portion comprises a flattened portion. In several embodiments, the knob is in a shape of a cam having the flattened portion. In several embodiments, once inserted into a pump receptacle of an infusion pump, the cartridge connector is configured to be positioned within the pump receptacle using a quarter turn that aligns the flattened portion with a corresponding flat surface of the pump to indicate to a user that the cartridge connector is correctly placed in the pump. In several embodiments, the lower side of the knob extends circumferentially from the shroud of the body and wherein the lower side of the knob comprises one or more nubs. In several embodiments, the one or more nubs are configured to contact an upper side surface of an infusion pump, the one or more nubs providing one or more contact points between the lower surface of the knob and the infusion pump. In several embodiments, the nubs are deformable and/or are configured to deform when the cartridge connector is twisted into place within the infusion pump. In several embodiments, the lower surface portion of the body comprises a bowl-shaped concavity and a surrounding lip, wherein the needle protrudes from and extends away from the bowl-shaped concavity. In several embodiments, the body comprises a projection extending axially upwardly from an upper surface of the body. In several embodiments, the projection comprises a fluid outlet. In several embodiments, the body is configured to receive the medicament through the needle and to deliver the medicament out of the body from the fluid outlet of the body, the needle and the fluid outlet of the body being in fluidic communication and providing a fluid path through the body. In several embodiments, the knob comprises a receptacle section extending upwardly into the lower side of the knob, the receptacle section configured to extend over and receive at least a portion of the projection of the body. In several embodiments, the knob comprises a fluid inlet located within the receptacle section, the fluid inlet being configured to receive the medicament. In several embodiments, the knob comprises a fluid path configured to deliver the medicament to an outlet port of the knob. In several embodiments, the connector comprises an interstitial space located between the projection of the body and the receptacle section of the knob a flexible membrane located within the interstitial space and extending over at least a portion of the projection of the body, the flexible membrane being configured to allow fluid to pass from the body outlet and into the knob inlet only after a threshold fluid pressure of the medicament is reached. [0020] In several embodiments, the knob is fixed to and/or unitary with the body For instance, in several embodiments, the knob is heat staked to, welded to (e.g., ultrasonically welded), glued to, affixed to, or a part of the body. In several embodiments, the cartridge connector is configured to simultaneously engage the medicament cartridge and a port of an infusion pump. In several embodiments, the needle of the cartridge connector is configured to pierce a septum of the cap of the first medicament cartridge. In several embodiments, the shroud comprises one or more of a snap arm configured to engage the cap of the first medicament cartridge, a detent, and/or a lug. [0021] In several embodiments, the cartridge connector is configured to engage a first port of the infusion pump the first port being different than a second port of the infusion pump. In several embodiments, as disclosed elsewhere herein, the shroud of the cartridge connector comprises one or more of a snap arm (e.g., configured to engage the cap of a first medicament cartridge), a detent, and/or a lug. In several embodiments, one or more of the snap arm, the detent, and/or the lug of the first cartridge connector is different than a snap arm, a detent, and/or a lug of a second cartridge connector. [0022] Several embodiments pertain to a medicament connector set for delivering a single or multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the medicament connector set comprises the cartridge connector as disclosed above or elsewhere herein as a first cartridge connector and the fluid conduit of the infusion set. In several embodiments, the connector set comprises a first infusion connector in fluidic communication with the first fluid conduit. [0023] Several embodiments pertain to a medicament connector set for delivering a single or multiple medicaments to a patient. Any of the embodiments described above, or described elsewhere herein, can include one or more of the following features. In several embodiments, the medicament connector set comprises the cartridge connector as disclosed above or elsewhere herein as a first cartridge connector. In several embodiments, the medicament connector set comprises a first cartridge connector and a second cartridge connector configured to engage a second medicament cartridge. In several embodiments, the second medicament cartridge connector comprises a body comprising a needle, a lower surface portion extending circumferentially from the needle, and a shroud extending axially away from the lower surface portion and configured to receive and fit over a portion of a second medicament cartridge that is configured to hold a second medicament. In several embodiments, the needle extends axially within the shroud away from the lower surface portion. In several embodiments, the second medicament cartridge connector comprises a knob connected to the body. In several embodiments, the knob of the second medicament cartridge connector comprises a lower side extending circumferentially from the shroud of the body, the knob comprising a fluid outlet configured to deliver the second medicament to a position outside the cartridge connector. In several embodiments, the knob of the first medicament cartridge connector comprises a lower side extending circumferentially from the shroud of the body of the first medicament cartridge connector, the knob comprising a fluid outlet configured to deliver the first medicament to a position outside the first cartridge connector. [0024] In several embodiments, the second cartridge connector is configured to engage a second port of the infusion pump the second port being different than the first port of the infusion pump. In several embodiments, the shroud of the second cartridge connector comprises one or more of a snap arm configured to engage the cap of the second medicament cartridge, a detent, and/or a lug. In several embodiments, one or more of the snap arm, the detent, and/or the lug of the first cartridge connector is different than the snap arm, the detent, and/or the lug of the second cartridge connector. In several embodiments, the first cartridge connector is configured to not engage the second medicament cartridge and/or wherein the second cartridge connector is configured to not engage the first medicament cartridge. In several embodiments, the first cartridge connector is configured to not engage the second port of the infusion pump and/or wherein the second cartridge connector is configured to not engage the first port of the infusion pump. [0025] Several embodiments pertain to an infusion system comprising the connector set as disclosed above or elsewhere herein and an infusion pump. Several embodiments pertain to an infusion system comprising the connector (e.g., a cartridge connector, an infusion connector, or both) disclosed above or elsewhere herein and the infusion site base disclosed above or elsewhere herein. [0026] Several embodiments pertain to a connector set for delivering a single or multiple medicaments to a patient, the medicament connector set comprising the cartridge connector disclosed above or elsewhere herein as a first cartridge connector and a first fluid conduit configured to receive the first medicament from the first cartridge connector. In several embodiments, the connector set further comprises a first infusion connector in fluidic communication with the first fluid conduit. In several embodiments, the first reservoir connector is the connector as disclosed above or elsewhere herein. [0027] Several embodiments pertain to a medicament connector set for delivering multiple medicaments to a patient, the medicament connector set comprising the first cartridge connector and the second cartridge connector disclosed above or elsewhere herein. In several embodiments, the connector set further comprises a first and second infusion connectors in fluidic communication with the first and second cartridge connectors via first and second fluid conduits, respectively. [0028] Several embodiments pertain to a system comprising one or more of a cartridge connector (or cartridge connector set), an infusion connector (or infusion connector set), a infusion base, a lumen assembly (or multi-channel lumen assembly), a pump, or any combination of any of the foregoing. BRIEF DESCRIPTION OF THE DRAWINGS [0029] Various embodiments are depicted in the accompanying drawings for illustrative purposes and should in no way be interpreted as limiting the scope of the embodiments. Any features, structures, components, materials, and/or steps of any of the embodiments can be combined or replaced with any features, structures, components, materials, and/or steps of any other of the embodiments to form additional embodiments, which are part of this disclosure. The illustrated embodiments are intended to demonstrate, but not to limit, the present disclosure. The proportions and relative dimensions and sizes of each component as shown in these drawings forms part of the supporting disclosure of this specification, but should not be limiting on the scope of this specification, except to the extent that such proportions, dimensions, or sizes are included in any individual claims. [0030] Figure 1A illustrates perspective view of an embodiment of an infusion pump engaged to a cartridge connector set and fluid channels showing the upper surface and the bottom side surface of the pump. [0031] Figure 1B is a second perspective view of the embodiment Figure 1A, this time showing the upper surface and the top side surface of the pump. [0032] Figure 1C is another perspective view of the embodiment Figure 1A showing the upper surface and the bottom side surface of the pump device where the connector set has been removed. [0033] Figure 1D is another perspective view of the embodiment Figure 1A showing the upper surface and the top side surface of the pump. [0034] Figure 1E is another perspective view of the embodiment Figure 1A showing the lower surface and the top side surface of the pump. [0035] Figure 1F is another perspective view of the embodiment Figure 1A showing the lower surface and the top side surface of the pump and the cartridge receptacles. [0036] Figure 1G is a view of the embodiment Figure 1A showing the cartridge receptacles of the pump. [0037] Figure 1H is another view of the embodiment Figure 1A showing the cartridge receptacles of the pump. [0038] Figure 1I is another view of the embodiment Figure 1A showing the cartridge receptacles of the pump. [0039] Figure 1J is a view of the upper side surface of the embodiment Figure 1A showing the cartridge receptacles of the pump. [0040] Figures 2A-2C show views of the embodiment of Figure 1A with its display screen and/or other portions of the pump face and housing removed, revealing various internal components of the pump. Figure 2A shows a view of the embodiment of Figure 1A with its display screen and pump face removed, revealing various internal components of the pump. Figure 2B shows another view of the embodiment of Figure 1A with its display screen and pump face removed, revealing various internal components of the pump. Figure 2C shows a portion of the cartridge drive assembly of the pump of Figure 1A. [0041] Figure 2D shows a view of the embodiment of Figure 1A bisected by a plane through the pump’s height and along the length and width of the pump. [0042] Figures 2E and 2F show cross-sectional views of the embodiment of Figure 1A in planes through the pump’s width and along the length and height of the pump, cutting the first cartridge receptacle and the second cartridge receptacle, respectively. [0043] Figures 2G and 2H show partially exploded views of the embodiment of Figure 1A with the display and bezel removed. As shown in Figure 2H, the pump comprises a lead screw, a threaded insert, and a drive nut. [0044] Figure 2I shows a view of the embodiment of Figure 1A bisected by a plane through the pump’s height and along the length and width of the pump. In this view, a medicament cartridge set and a cartridge connector set are present and/or engaged to the pump. [0045] Figure 3A shows a view of the upper side surface of the embodiment of Figure 1A. [0046] Figure 4A illustrates a perspective view of another embodiment of a pump, showing the upper surface and top side surface of the pump. [0047] Figure 4B shows a view of the embodiment of Figure 4A bisected by a plane through the pump’s height and along the length and width of the pump. In this view, a medicament cartridge set and a cartridge connector set are present and/or engaged to the pump (along with corresponding fluid conduits). [0048] Figure 5A shows a view of the top side surface of the embodiment of Figure 1A and Figure 4A, respectively. [0049] Figures 6A and 6B are views of a cartridge connector set comprising two cartridge connectors and corresponding fluid conduits (tubing). Figure 6A shows a perspective view of the cartridge connectors (e.g., the connector set). Figure 6B shows a bottom view of the cartridge connectors. [0050] Figure 6C illustrates an embodiment of the cartridge connector providing a visual indication of when the connectors from the connector set are unlocked or locked within the pump chamber, respectively. [0051] Figure 6D illustrates a cross-sectional view of the connectors of Figure 6A. [0052] Figure 6E illustrates a view of the connectors of Figure 6A where the body of one connector has been separated from its knob. [0053] Figure 6F-G illustrate different views of one of the connectors of Figure 6A where the body of the connector has been separated from its knob. [0054] Figure 6H illustrates a cross-sectional view of one of the connectors of Figure 6A. [0055] Figure 6I illustrates an additional cross-sectional view of the connectors of Figure 6A. [0056] Figure 6J is a view of another embodiment of a cartridge connector, this one having a fitting as part of its knob. [0057] Figure 6K is a different view of the cartridge connector of Figure 6J. [0058] Figure 6L is a bisected view of the cartridge connector of Figure 6J. [0059] Figures 6M-6T are views of the knob of the cartridge connector of Figure 6J. Figure 6M is a bottom view of the knob. Figure 6N is a top view of the knob. Figure 6O is a first side view of the knob. Figure 6P is a second side view of the knob. Figure 6Q is a perspective view of the knob showing the bottom of the knob. Figure 6R is another perspective view of the knob, this time showing the top of the knob. Figure 6S is an expanded view of a portion of the knob shown in Figure 6T. Figure 6T is a bisected view of the knob. [0060] Figure 7A is a view of another embodiment of a cartridge connector set comprising two cartridge connectors. [0061] Figure 7B illustrates cross-sectional views of the connectors of Figure 7A. [0062] Figures 7C illustrate a bottom view of the connectors of Figure 7A. [0063] Figures 7D-E illustrate views of the connectors of Figures 6A and 7A. [0064] Figure 7F illustrates a cross-sectional view of an embodiment of a connector set engaged to medicament cartridges. [0065] Figures 7G-7H show views of a connector having a check-valve. [0066] Figure 7I is a view of another embodiment of a cartridge connector having a fitting and a corresponding mating fitting to which the fitting of the cartridge connector engages. [0067] Figure 7J is a view of another embodiment of a cartridge connector having a fitting and a corresponding mating fitting to which the fitting of the cartridge connector engages. The embodiment of Figure 7J includes a similar fitting to that shown for the embodiment of Figure 6K. [0068] Figures 8A-8B illustrate cross-sectional views of embodiments of connector sets engaged to medicament cartridges within a pump. [0069] Figures 8C-8D illustrate cross-sectional views of embodiments of connector sets engaged to medicament cartridges. [0070] Figure 8E illustrates a view of an embodiment of a connector set engaged to medicament cartridges. [0071] Figure 9A illustrates an embodiment of a dual lumen portion of a multi- channel lumen assembly. [0072] Figures 10A-B illustrate perspective views of a dual infusion set base where 10A also illustrates an insertion implement. [0071] Figures 11A-B illustrate perspective views of dual medicament distribution connectors where 11A also illustrates a cover for the distribution connectors. [0072] Figures 12A-B illustrate views of a dual medicament infusion set where 12B is a cross-sectional view from the top. [0073] Figure 12C illustrates a top view of a portion of another embodiment of an infusion set with the second infusion connector removed from the hub of the infusion base. [0074] Figure 12D-12G illustrate the embodiment of Figure 12C with the second infusion connector attached. As shown, the infusion set is configured to infuse multiple medicaments through a single puncture point in the skin (a single site infusion set). [0075] Figure 12H illustrates another embodiment of a single puncture site infusion set. [0076] Figure 12I illustrates another embodiment of a single puncture site infusion set. [0077] Figure 12Ji and 12Jii illustrate another embodiment of a single puncture site infusion set. [0078] Figures 12Ki-12Kiii illustrate embodiments of a coaxial delivery conduit with a first and second tubular delivery member. Figure 12Ki shows the coaxial delivery conduit with its first and second tubular members. Figure 12Kii shows the embodiment of Figure 12Ki where medicament is being delivered through the first tubular member. As shown, the first tubular member may include lateral apertures through which the medicament may be distributed. Figure 12Kiii shows the embodiment of 12Ki where medicament is being delivered through the second tubular member. [0079] Figures 12L illustrates another embodiment of a coaxial delivery conduit with a first and second tubular delivery member. [0080] Figures 12M-12O illustrate embodiments of separate infusion bases having tubular delivery members. As shown in Figure 12M, the lateral apertures may be distributed evenly about the delivery member(s). As shown in Figure 12N, the lateral delivery apertures may be located on a portion of a delivery member. As shown in Figure 12O, the lateral delivery apertures may be located on a portion of a delivery member and the delivery members may be of different lengths (e.g., distributing at different depths). [0073] Figures 13A-B illustrate a single medicament infusion housing set base where an insertion implement is attached (13A) or detached (13B). [0074] Figures 14A-B illustrate perspective views of a single medicament distribution connector where 14A also illustrates a cover for the distribution connector. [0075] Figures 15A-B illustrate views of a single medicament infusion base set where 15B is a cross-sectional view from the top. [0081] Figures 16A-E illustrate various configurations of dual medicament infusion set bases, connectors, and covers. Figure 16A shows an embodiment of with the right site base, connected to a right site base cover. Figure 16B shows the second site base connected to a second site base cover. Figure 16C shows the first site connector connected to a first site connector cover. Figure 16D shows the second (left) site connector connected to a second (left) site connector cover. Figure 16E shows the dual-medicament infusion site base connected to a dual-medicament site base cover. [0082] Figures 17A illustrates a perspective view of a medicament distribution connector (e.g., infusion connector). [0083] Figures 18A-E illustrate various configurations of dual medicament infusion set base with distribution connectors. DETAILED DESCRIPTION [0084] Some embodiments described herein pertain to medicament infusion systems for one or more medicaments and the components of such systems (e.g., infusion pumps, medicament cartridges, cartridge connectors, lumen assemblies, infusion connectors, infusion sets, etc.). Some embodiments pertain to methods of manufacturing infusion systems and components thereof. Some embodiments pertain to methods for using any of the foregoing systems (e.g., combinations of components) and/or components for infusing one or more medicaments to a patient. Several embodiments disclosed herein ensure proper channeling of medicaments to patients. While multiple recognition features can be used on the various components disclosed herein to reduce any opportunity for mischanneling, no single feature or collection of features is essential or indispensable. For example, some embodiments may include each recognition feature and/or component disclosed herein, while others may not include or may lack one or more features or components disclosed herein while still achieving proper channeling. Any combination of features and/or components is envisioned. As exemplary illustrations, the following combinations are provided. In some embodiments, an infusion system may include an infusion pump, but not medicament cartridges. In some embodiments, an infusion system may include medicament cartridges and cartridge connectors, but not a pump. In some embodiments, an infusion system may include cartridge connectors and an infusion pump, but not medicament cartridges. In some embodiments, an infusion system may include infusion connectors, a lumen assembly, cartridge connectors, an infusion pump, but not medicament cartridges or an infusion set. In some embodiments, an infusion system may include infusion connectors, a lumen assembly, and cartridge connectors, but not medicament cartridges, an infusion pump, or an infusion base(s). In some embodiments, an infusion system may include infusion connectors, a lumen assembly, cartridge connectors, and an infusion base(s), but not medicament cartridges or an infusion pump. Any feature, structure, component, material, step, or method that is described and/or illustrated in any embodiment in this specification can be used with or instead of any feature, structure, component, material, step, or method that is described and/or illustrated in any other embodiment in this specification. Additionally, any feature, structure, component, material, step, or method that is described and/or illustrated in one embodiment may be absent from another embodiment. [0085] U.S. Publication Nos. 2021/0030947 A1 and 2021/0030949 A1, which are hereby each incorporated by reference in their entireties, disclose medicament infusion systems (including systems configured to delivery multiple medicaments to a subject), components thereof (e.g., pump systems, cartridge connectors, cartridges, connector sets, multi-channel lumen assemblies, infusion sets, combinations of any of the foregoing, etc.), methods of making each of the foregoing, and methods of using each of the foregoing. Introduction [0086] As disclosed elsewhere herein, sustained delivery, pump driven medicament injection devices generally include a delivery cannula mounted in a subcutaneous manner through the skin of the patient at an infusion site. A pump draws medicine from a reservoir and delivers it to the patient via the cannula. The injection device may include a channel that transmits a medicament, receiving it via an inlet port and providing a fluid path to the delivery cannula. The medicament may be transmitted to the patient via the cannula, which delivers the medicament to the subcutaneous tissue layer where the delivery cannula terminates. Infusion devices may be configured to deliver one medicament to a patient or multiple medicaments to a patient. [0087] Though multi-medicament delivery systems exist, a drawback is that the patient or physician may accidentally load, and thus administer or cause to be administered, an incorrect medicament (e.g., pharmaceutical, hormone, etc.). For instance, in a multi- medicament infusion device, a user may load a medicament in an incorrect pump receptacle, which leads to the mistaken belief that he or she is administering one medicament when they are accidentally supplying a different one. The accidental administration of an incorrect medicament to the patient can have serious and potentially fatal consequences. [0088] For example, standard-of-care insulin therapies for regulating blood glucose in diabetic patients may involve subcutaneous infusion of insulin via an insulin pump. If the amount of dosed insulin is excessive, it can lead to hypoglycemia or a situation of impending hypoglycemia. To combat and/or reverse such adverse situations, individuals typically consume additional carbohydrates (e.g. sweet juice or glucose tablets). Individuals can alternatively and/or additionally administer a so-called “rescue dose” of a counter- regulatory agent, such as glucagon. A counter-regulatory agent combats the effect of the excess regulatory agent dose (e.g., excess insulin) alleviating or substantially preventing adverse effects related to the excess dose. However, if a patient is given additional insulin instead of the intended rescue dose of glucagon, the results could be catastrophic, potentially leading to death. Similarly, during a diabetic episode, if a patient requires insulin but is given glucagon instead, that administration could exacerbate the episode and could lead to devastating effects and could be lethal. [0089] The proper channeling in medicament dosing is, therefore, critical, especially where one medicament is used to achieve one effect while another is used to achieve a different and/or the opposite effect (e.g., as in the case of insulin and glucagon). In a multi-medicament automated system, if the medicaments are accidentally loaded in the incorrect cartridges or incorrect cartridge chambers of a pump, the automated system could deliver an ineffective (and/or potentially harmful) medicament to the patient. This phenomenon of incorrect medicament loading and/or administration in automated systems is called cross-channeling (or mischannelling). As illustrated above, cross-channeling is dangerous not only because the wrong medicament can lack the intended therapeutic effect, but also because the wrong medicament could have the opposite of an intended effect (or some other side effect that is unanticipated or undesired). Also as illustrated above, improper channeling not only fails to alleviate the patient’s condition, but could make the patient’s condition worse, or cause a new problem-state for the patient. Improper channeling (e.g., mischanneling) could cause a negative feedback loop (e.g., in an autonomous device that monitors the patient’s state), wherein the control system attempts to adjust the patient’s disease state in one direction, but the delivery of the incorrect medicament exacerbates or causes no effect on the disease state. Sensing this, the control system can trigger further doses of the wrong medicament in an attempt to control the patient’s condition, while actually causing the patient’s condition to further deteriorate (or causing overdosing of the incorrect medicament). [0090] Additionally, in certain circumstances or environments, commercial diabetic drug infusion systems may be inadequate to prevent improper dosing, even where the proper medicament is being administered. For example, runaway dosing can occur in some circumstances, or inadequate dosing in others. [0091] While diabetic drugs (e.g., insulin and glucagon) are used as exemplary medicaments above and elsewhere herein, improper channeling (or dosing) can have deleterious effects in many multi-medicament regimens because a medicament is not administered to the patient at the necessary time (and/or at a necessary level), or an incorrect medicament is administered at a dangerous level. Mischanneling can be detrimental in other drug combinations that regulate pancreatic enzymes, other combinations of drugs meant to maintain the body’s equilibrium in one direction or the other, or simply where a patient requires multiple drugs regardless of any relationship between the drugs or a common disease state (e.g., where one drug treats one disease state and another a completely unrelated disease state). Thus, the embodiments and considerations provided herein can be applied to any drug combination. Additionally, while cross-channeling can refer to systems with two medicaments, the term cross-channeling as used herein can also refer to systems where more than two medicaments are used and/or where a single medicament is used (for example, when a single medicament is improperly placed in a distribution system). [0092] Some embodiments disclosed herein address one or more of problems associated with these problems (e.g., mischanneling, runaway or inadequate dosing, etc.) or others. Described herein are infusion systems for single or multiple medicaments and various connectors, tubes, cartridges, pumps, infusion sets, and/or systems comprising any one or more of the foregoing that ensure, help ensure, and/or substantially aid in providing proper channeling and/or dosing of each medicament to the patient. Certain embodiments of the infusion systems and components thereof described herein are configured to prevent, minimize, lessen, and/or otherwise help avoid the occurrence of cross-channeling and/or improper dosing of medicaments. In some embodiments, where medicaments are supplied by the infusion systems disclosed herein, components comprising recognition features as described herein are configured to impede, prevent, minimize the occurrence of, or otherwise inhibit any opportunity for a user to inadvertently place a medicament in the incorrect position and/or deliver an incorrect medicament (and/or an improper amount of a correct medicament). [0093] Cross-channeling may be avoided by providing recognition features (e.g., unique differentiating recognition elements) that allow mating between only particularly shaped components within an infusion system. In some embodiments, the infusion system comprises an infusion pump with one, two, or more infusion chambers (or pump chambers) and one or more recognition features. In some embodiments, the system further comprises cartridges filled with different medicaments, and connectors and tubing having recognition features that connect to the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments. In certain variants, each type of cartridge for each type of medicament has one or more unique differentiating features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge). Recognition features can comprise, for example geometric or shape-based features, that allow for unique coupling between components of the system. These features may be protrusions (e.g., solid items that take up space) or protrusion-receiving spaces (e.g., apertures or other spaces that may be shaped receive protrusions). A type of connector that has unique differentiating features can engage corresponding (e.g., mating, paired, and/or matched) features in the pump housing and allow for insertion of a proper cartridge into the proper infusion chamber. A cartridge with unique features can interact with a pump infusion pump having corresponding features (e.g., a drive shaft or pump chamber with corresponding features). Improper dosing can be avoided with certain design features disclosed herein, including seals, valves, and other implements incorporated into the components disclosed herein. [0094] The following disclosure provides additional details regarding configurations of systems and components for avoiding cross-channeling. While the following description provides context and examples, it should not be interpreted to limit the scope of the inventions covered by the claims that follow in this specification. The Infusion System [0095] Some embodiments disclosed herein pertain to infusion systems configured to delivery one or more medicaments without cross-channeling and/or configured to prevent improper dosing of a medicament. In certain variants, the system comprises one or more of the following: an infusion pump (configured to receive one or more medicament cartridges in one or more cartridge receptacles), one or more cartridge connectors (configured to engage one or more medicament cartridges), one or more medicament cartridges, an infusion base (configured to deliver the medicament to the patient via a piercing element that may comprise a cannula or needle penetrating the skin of the patient), one or more infusion connectors configured to engage with the infusion base, and a fluid conduit in fluid communication with the one or more cartridge connectors and/or the one or more infusion connectors. In several embodiments, the infusion system (or components thereof) include one or more design features that make it compact. In some variants, the infusion system (or components thereof) are especially suitable to be ambulatory and/or wearable on a patient, allowing the patient freedom of movement (e.g., day-to-day activities, including but not limited to, work, engaging in exercise, swimming, air travel, etc.). [0096] In some implementations, where the infusion system is configured to deliver multiple medicaments (instead of just one), the infusion system may be adapted to receive multiple medicaments from multiple medicament cartridges. As an illustration, in a two medicament infusion system, the system may comprise multiple different configurations of components, including or lacking one or more components selected from two medicament cartridges, an infusion pump configured to receive the two cartridges (e.g., in different cartridge receptacles), cartridge connectors configured to engage the medicament cartridges and/or the infusion pump (e.g., at or near the cartridge receptacles), an infusion set configured to deliver the medicaments to the patient (e.g., a piercing element for the first medicament and a piercing element for the second medicament), two infusion connectors configured to engage with the infusion set, and fluid conduits, each in fluid communication with one cartridge connector and one infusion connector (e.g., providing separate flow paths). A two-medicament infusion system is shown in Figure 1A, where the system comprises two different cartridge connectors with corresponding fluid conduits and a pump. Additionally, where the system is configured to delivery three or more medicaments, additional cartridges, cartridge receptacles, cartridge connectors, infusion connectors, and piercing elements may be provided as needed (though the system may also lack any one or more of these components). As disclosed elsewhere herein, while two or more medicaments may be delivered by the infusion system, several embodiments pertain to pumps that deliver a single medicament (e.g., having a pump with only one cartridge receptacle or multiple cartridge receptacles configured to receive a single type of medicament cartridge, for example, insulin). [0097] In some embodiments, as disclosed elsewhere herein, the system and/or components thereof include unique mating features and design elements (recognition features). These recognition features may ensure that each portion of the system can only be connected within the system in a unique way or configuration (e.g., a proper way), thus preventing cross-channeling (e.g., mischanneling). In some embodiments, where different medicaments are delivered by a single system (or component thereof), the medicaments may be kept completely separate throughout their residency within the system (or components thereof) and may have different fluid paths to a patient. For example, cartridge connectors and fluid conduits may be used to provide separate fluid pathways that terminate at designated delivery members (e.g., needles, cannulas, etc.) within a base (e.g., the infusion set), thereby enabling independent delivery (e.g., subcutaneous or otherwise) of medicaments separately. [0098] In certain embodiments, design features of the disclosed system (and/or components thereof) give rise to the following advantages or others: (1) allowing the user to easily connect and disconnect the components independently from any medicament sources as well as from the infusion ports or sites; (2) mitigating the possibility of mischanneling that occurs when a user accidentally connects the wrong components together; (3) mitigating possibility for improper dosing levels; (4) mitigating loss of and or contamination of medicaments; (5) allowing for a single or multistep insertion of the dual-cannula infusion site or port. In some embodiments, the system and components described herein can further comprise visual or brail call-outs in addition to or instead of various paired physical features disclosed herein. For instance, in some implementations, the components can comprise call- outs with wording indicating a proper medicament. In some variants, different colors (red, blue, yellow, green, orange, violet, etc.) or lengths (or other variables) to provide visual feedback regarding appropriate medicaments for appropriate components. [0099] In some embodiments, as stated elsewhere herein, the infusion system can be used to provide separate fluid pathways for a variety of medicaments (e.g., drugs, hormones, proteins, pharmaceuticals, biologics, etc.) dissolved in a variety of liquid carriers (and/or liquid drugs). In certain embodiments, different liquid vehicles may be preferred based on the solubility, stability, or sensitivity of the medicament in a particular carrier. In some embodiments, aqueous solutions (buffers, etc.) are used as a delivery vehicle for the medicament. In certain variations, solvents such as DMSO are used to dissolve medicaments. In some embodiments, solvent/aqueous mixtures are used. [0100] In some implementations, a dual medicament system configured to receive insulin and glucagon cartridges is provided. In another implementation, the system may comprise a pump with multiple cartridge receptacles (e.g., chambers) that are configured to receive medicament cartridges containing an identical medicament (and not a different medicament) and/or configured to interact with multiple identical cartridge connectors. For example, in some embodiments, the infusion pump may have two medicament receptacles that are identical and that include identical recognition features. These receptacles may both be configured to receive identical medicament cartridges and/or may be configured to engage cartridge connectors that are the same (e.g., two cartridges contain insulin and/or two cartridge connectors that are both configured to engage insulin cartridges). In such a configuration, the system and its components (e.g., the medicament cartridges, infusion pump, cartridge connectors, infusion set, infusion connectors, and a fluid conduit) are configured to receive two (or more) medicament cartridges comprising a particular medicament (e.g., insulin) and not a medicament cartridge comprising a different medicament (e.g., glucagon). By providing a system that accommodates two or more cartridges of the same medicament (and that prevents or inhibits the insertion or connection of cartridges having other medicaments), the system operates for a longer period of time without the need for refilling or adding additional cartridges. Moreover, an expended single cartridge (e.g., one that is empty or close to empty) can be changed on the fly by the user without disrupting and/or delaying the flow of medicine from a second cartridge that is providing the medicament to the patient. In some embodiments, the pump is configured to receive a single medicament cartridge and the system comprises single components to allow the delivery of the same (e.g., a single cartridge connector, a single channel lumen assembly (that may comprise the cartridge connector), a single infusion connector, a single infusion base, a single medicament cartridge, etc.). [0101] The following sections provide additional information regarding individual components of the infusion systems disclosed herein. While these components may be described as being part of an infusion system, it is to be understood that, each of these components (e.g., the infusion pump, cartridge connectors, medicament cartridges, infusion set, infusion connectors, and fluid conduit) may be taken individually and/or apart from the system (e.g., as a standalone infusion pump, cartridge connector, medicament cartridge, infusion set, infusion connector, multi-channel lumen assembly, and fluid conduit). Likewise, where a component is described in isolation, it may be part of an infusion system (that may include any combination of components), as disclosed herein. Also, any combination of recognition features within the infusion system can be mixed and matched to address the mischanneling problem just as any dosing safety features may be mixed and matched to address improper administration issues. In several implementations, not all the recognition features or safety features disclosed herein need to be used in a particular embodiment. For instance, as disclosed elsewhere herein, a cartridge connector may be uniquely shaped in a way that allows it to only engage with one medicament vial (and not others) and uniquely threaded so that it only engages a corresponding cartridge receptacle in a pump. In such an embodiment, such features may be sufficient to avoid mischanneling and other features need not be included. To illustrate, in such a configuration, the cartridge receptacle of the pump may lack a recognition feature configured prevent insertion of a cartridge and instead the connector is configured to engage a particular medicament cartridge and a particular cartridge port in the pump. Pump System [0102] As disclosed elsewhere herein, some embodiments, pertain to infusion pumps (e.g., pump systems). In some implementations, an infusion pump as disclosed herein is a part of and/or a component of an ambulatory infusion system. [0103] In some embodiments, as shown in Figures 1A, 1B, and 1E, the pump may include a face P1002 (e.g., a front), a backing P1003 (e.g., a back), a bottom side P1005 (e.g., a lower side surface), a top side P1004 (e.g., an upper side surface), a first side surface P1006' (e.g., a right side surface), and a second side surface P1006'' (a left side surface). As shown in Figures 1A and 1B, the pump face P1002 and pump backing P1003 may each extend (e.g., laterally as a plane) along the upper side surface P1004 and lower side surface P1005 of the pump P1000 providing a pump width P(w). The pump face P1002 and pump backing P1003 may each extend (e.g., longitudinally as a plane) between the lower side surface P1005 and upper side surface P1004 in a direction along the first side surface P1006' and second side surface P1006'' of the pump P1000, providing a pump length P(l). As shown in Figure 1B, the pump P1000 may also have a height P(h) extending between the pump face P1002 and the pump backing P1003 in a direction along the first side surface P1006' (and/or along the second side surface P1006''). In some embodiments, the face P1002, backing P1003, lower side surface P1005, upper side surface P1004, first side surface P1006', and second side surface P1006'' of the pump provide an outer perimeter of the pump. [0104] In several variants, the infusion pump P1000 includes a pump housing P1001 that encases and/or houses one or more internal components of the infusion pump. As shown in 1C (also visible in Figures 1A, 1B, and 1D-1F), in certain implementations, the pump housing P1001 can comprise a bezel P1001' and a lower portion P1001''. In some embodiments, the lower portion P1001'' provides a frame onto which the bezel fits and/or connects. As shown in Figure 1C, a portion of the lower portion P1001'' may extend to the pump face P1002. In some embodiments, the lower portion P1001'' and/or the frame of the lower portion extends to the face of the pump to provides the upper side surface P1004 of the pump P1000. In some embodiments, the upper and lower portions of the housing may be sonically welded together, snap fit, glued or otherwise affixed to one another. In some embodiments, the upper and lower portions of the housing may be different materials or the same. In certain implementations, for example, the lower portion is a metal and the upper portion is not. In some implementations, the upper portion is polymeric and/or plastic, and the lower portion is not. In some embodiments, both the lower portion and the upper portion are independently a polymeric material (e.g., a plastic) or a metal. [0105] In several embodiments, a generally rectangular prism shaped configuration of the pump P1000 (as shown) has been found to advantageously accommodate internal pump components in a compact way (e.g., suitable for wearing). The compact nature of the rectangular prism configuration, along with one or more other design features disclosed, reduce bulk and increase the ease with which the disclosed infusion system can be worn and/or used. In several embodiments, the compact nature of the design increases user compliance and convenience. While a rectangular prism provides certain advantages with regard to the configuration of the internal components of the pump, in other embodiments, other shapes may be adopted (e.g., generally cube-shaped, oblong, cylindrical, oval cylindrical, etc.). In some embodiments, as disclosed elsewhere herein, the housing of the pump P1001 has rounded edges to improve shock absorption and/or resistance to cracking when impacted (e.g., by dropping, etc.). [0106] In certain embodiments, as shown in Figure 1A, the pump P1000 comprises a display region P1007. In some embodiments, as disclosed elsewhere herein, the display region P1007 is a display screen and/or a touch screen. In some variants, the display region P1007 may be configured to provide the user with data (e.g., alphanumeric, image- based, etc.) regarding medicament levels, drug dosing rates, information about blood sugar levels, and/or other diagnostic information. In certain configurations, as disclosed elsewhere herein, the display screen allows the user to adjust the distribution of medicaments or other pump and delivery settings (including one or more control features disclosed herein). In some embodiments, the bezel provides support for and/or engages the display screen, holding it in place. [0107] In some embodiments, as shown in Figure 1A and 1B, the lower side surface P1005 of the pump P1000 may comprise a touch pad P1010. In some embodiments, the touch pad P1010 is a finger pad having a curved indentation configured to receive a finger of a user. In several variants, as disclosed elsewhere herein, a capacitive touch sensor may be located under the finger pad P1010 and/or is in electronic communication with the finger pad P1010. In other embodiments, additional capacitive touch sensors may be in communication with different surfaces of the pump (e.g., elsewhere on the pump face, pump backing, the upper side surface, the first side surface, or the second side surface). [0108] In certain variants, additionally or alternatively, the display P1007 may be a capacitive touch sensor and/or a capacitive touch sensor may be located at or behind a portion of the pump face P1002 (e.g., making the display a touchscreen). In some embodiments, a capacitive touch sensor of the display P1007 may be activated by touching the display P1007 in designated locations and/or by touching the separate finger pad P1010 (and/or a different the surface) of the pump P1000. In some embodiments, the capacitive touch sensor of the display P1007 may be used to control and/or send signals to components within the pump P1000, for example, allowing a user to control one or more aspects of the drug delivered from the reservoirs located within the pump. For instance, in some embodiments, a user can swipe (or drag) a finger in one direction (i.e., left, right, down, up, or otherwise) over the capacitive touch sensor display P1007 to change delivery capabilities (e.g., rate, etc.). Pump Cartridge Receptacles [0109] Figures 1A and 1B show a multiple medicament pump P1000 engaged to two cartridge connectors C1001, C1101 (e.g., a first and a second cartridge connector). These cartridge connectors can be configured to attach to different medicament cartridges and to simultaneously engage the pump via cartridge receptacles (e.g., first and second cartridge receptacles). As show, a first and second fluid conduit T1001, T1101 are engaged to the first and second cartridge connectors C1001, C1101, respectively. Though not visible in Figure 1A and 1B, medicament cartridges may be housed in chambers that are engaged with the cartridge connectors C1001, C1101. Also visible in Figures 1A and 1B is tubing a first tube and a second tube that is configured to provide a fluid path to the infusion set and/or infusion connectors (not shown). [0110] As shown in Figures 1C and 1D, the pump 1000 comprises cartridge receptacles P1100, P1110 (e.g., cartridge holders, cartridge chambers, and/or cartridge repositories). As shown, the cartridge receptacles include medicament receptacle inlet ports P1100', P1110'. In Figures 1C-1F, the cartridge connectors C1001, C1101 shown in Figures 1A and 1B (and corresponding medicament cartridges M1001, M1101, visible in Figure 2I) have been disengaged and removed from the pump P1000, making the cartridge receptacles P1100, P1110 and inlet ports P1100', P1110'' visible. In some embodiments, these cartridge receptacles are configured to house (e.g., receive, secure in place, hold, etc.) the medicament cartridges M1001, M1101 (as shown in Figure 2I). [0111] As shown in Figures 1A, 1B, and 1D-1F, the pump P1000 may comprise a first medicament chamber P1100 that is different from a second medicament chamber P1110. In some variants, one or more design features (e.g., recognition features) of the inlet ports P1100', P1110' and/or other features within the cartridge receptacles P1100, P1110 prevent proper engagement of the cartridge connectors and/or prevent insertion of an improper cartridges into an incorrect chamber. For instance, as shown in Figures 1E-1J, these chambers P1100, P1110 or inlet ports P1100', P1110' may include one or more recognition features P1101, P1102, P1103, P1111, P1112, P1113 that prevent or inhibit coupling to improper components. [0112] In some embodiments, the cartridge receptacles are configured to receive particular medicament vials and not others. For instance, a given receptacle can be configured to not receive an incorrect medicament cartridge (e.g., by virtue of the diameter, length, size, or shape of the medicament cartridge). In other embodiments, the cartridge receptacles may be configured to receive different types of cartridges indiscriminately. In such embodiments, even where a given cartridge receptacle can receive differently shaped medicament cartridges and/or cartridges for different medicaments (e.g., the first receptacle could receive either a glucagon cartridge or an insulin cartridge), mischanneling may still avoided by virtue of the cartridge connectors and the inlet ports P1100', P1110'. [0113] For instance, as disclosed elsewhere herein, a first cartridge connector C1001 may be configured to engage only a specific medicament cartridge M1001 (e.g., a first medicament cartridge) and a second cartridge connector C1101 may be configured to engage only a corresponding specific medicament cartridge M1101 (e.g., a second medicament cartridge). Though the pump receptacles P1100, P1110 themselves may not be configured to prevent the insertion of an incorrect medicament cartridge, the inlet ports P1100', P1110' may include unique mating features (e.g., recognition features) that allow them only to engage a specific medicament cartridge connector with corresponding mating features. To illustrate, the first receptacle may be configured to engage the first cartridge connector and not the second cartridge connector. The second receptacle may be configured to engage the second cartridge connector and not the first cartridge connector. [0114] In other embodiments, a given receptacle can be configured to not receive an incorrect medicament cartridge (e.g., by virtue of the shape of the medicament cartridge) and to also not engage an incorrect cartridge connector. [0115] In some embodiments, the pump is configured to receive a medicament cartridge that is already connected to a connector. To illustrate, a medicament cartridge may be connected to a cartridge connector, then the pump can receive the cartridge and connector simultaneously (only allowing engaging of an appropriate connector and/or cartridge). Alternatively, or additionally, in several embodiments, the pump may receive the medicament cartridge (e.g., loosely, without and/or free from the cartridge connector). Then, the pump may be configured to receive the cartridge connector into the cartridge receptacle over the cartridge, where the connector can be locked in position (e.g., twisted into place) within the pump. In such embodiments, the connector may be configured to simultaneously engage both the vial and the pump. Where the connector or medicament cartridge are improper for a given receptacle, certain recognition features can prevent engagement of the connector. For instance, where the cartridge and connector are not paired, the cartridge be of insufficient diameter to receive the cartridge, preventing the engagement of the cartridge connector to it and holding the cartridge connector in a position that is too far from the pump to engage the inlet port. Alternatively, the connector may receive the incorrect vial, but may travel too deep within the receptacle to engage the inlet recognition features of the pump. [0116] As shown in Figure 2I, the inlet port P1100' of the first medicament chamber P1100 may be configured to engage a first cartridge connector C1001 and/or receive a first cartridge M1001. In some embodiments, as shown, the inlet port P1110'' of the second medicament chamber P1110 is configured to engage a second cartridge connector C1101 and/or receive a second cartridge M1101. In some embodiments, the inlet port P1100' of the first medicament chamber P1100 is configured not to engage a cartridge connector that engages the second inlet port P1110'' (e.g., the second cartridge connector C1101). In some embodiments, additionally or alternatively, the inlet port P1110'' of the second medicament chamber P1110 is configured not to engage a cartridge connector that engages the first inlet port P1100' (the first cartridge connector C1001). In the embodiment shown in Figure 1D, the first receptacle P1100 is configured to house or receive a cartridge and cartridge connector for a regulatory agent (e.g., insulin) and the second medicament chamber P1110 is configured to house or receive a cartridge and cartridge connector for a counterregulatory agent (e.g., glucagon). [0117] As shown in Figures 1D-1I, each of the pump chambers P1100, P1110 comprises one or more recognition features P1101, P1102, P1103, P1111, P1112, P1113 configured to prevent or inhibit mischannelling. As shown, the features may be protrusion- shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of a cartridge connector corresponding to the pump chamber. These mating features facilitate attachment of and/or to prevent connection of in appropriate components. While, in the depicted embodiment, radial divots (e.g., divots or notches shaped to receive corresponding and/or mated protruding features) are distributed circumferentially about the inlet ports P1100', P1110', in other embodiments, protrusions (e.g., tabs, lugs, detents) and/or a mixture of protrusions and divots may be provided on or within the inlet ports to prevent or inhibit mischannelling (not shown). In such an embodiment, corresponding radial divots and/or protrusions may be provided on a corresponding cartridge connector. [0118] In some embodiments, as shown, the features of the pump receptacles P1100, P1110 may be located at a position proximal to the entrance of the receptacle (e.g., at the inlet ports P1100', P1110') to allow interaction with a corresponding cartridge connector. As shown in Figures 6A-6B, cartridge connectors C1001, C1101 corresponding to the pump receptacles P1100, P1110, respectively, comprise corresponding protrusions (e.g., tabs, lugs, detents). In some embodiments, these protrusions include lugs C1010, C1011, C1110, C1111 and/or detents C1012, C1112. In some embodiments, as described elsewhere herein, the protrusions (e.g., projections) are configured to mate with (e.g., slide into) corresponding openings configured to receive such projections. As illustrated in Figures 1D-1J and 6B, each cartridge chamber may have a plurality of recognition features configured to mate with corresponding recognition features of the cartridge connectors. In the illustrated embodiment of 1D-1J, each pump chamber P1100, P1110 comprises three radial carve-outs configured to engage correspondingly shaped lugs and detents of corresponding cartridge connectors C1001, C1101, respectively, shown in Figure 6B. These recognition features may be configured to engage an appropriate connector, to prevent or inhibit engagement of an improper cartridge connector (e.g., that is not corresponding and that lacks one or more corresponding protrusions), or both. [0119] While in the embodiment shown in Figures 1D-1J each inlet port 1100', 1110' has three radial divots as recognition features, in some embodiments, each pump chamber can independently have one, two, three, four five, or more recognition features (e.g., divots and/or protrusions) configured to receive corresponding recognitions features (e.g., protrusions and/or divots) from corresponding cartridge connectors. Additionally, as apparent here, while the cartridge receptacles have been described as comprising divots and the cartridge connectors as comprising protrusions, the opposite configuration is also possible (where divots are on the cartridge connectors and protrusions on the receptacles). Likewise, in some embodiments, types of recognition features could be mixed and matched on a particular receptacle or cartridge connector (so the receptacle comprises both protrusions and divots and the corresponding cartridge connector has corresponding divots and protrusions). In yet another variation, a cartridge receptacle can comprise only divots and a different cartridge receptacle in the same pump can comprise only protrusions. In such an embodiment, the corresponding cartridge connector set can comprise a connector with corresponding protrusions and a connector with corresponding divots, respectively. As exemplary embodiments, where a first cartridge connector comprises five protruding features (e.g., three lugs and two detents; not shown), a corresponding first receptacle (e.g., a first inlet port) would comprise five divots to receive those protrusions (e.g., three lug openings and two detent openings). A second cartridge connector could comprise four divots (e.g., two lug openings and two detent openings) configured to engage a corresponding second receptacle comprising four protrusions (e.g., two lugs and two detents) to be received within those divots. [0120] In some embodiments, as shown in Figures 1D-1J, the lug openings and detent openings may be various different sizes (e.g., circumferential lengths, radial heights, etc.). For example, as shown in Figure 1J, a lug opening of one cartridge receptacle may be of one length lug(l'), a second may be of a second length lug(l''), these lengths may be different from each other and/or from the lug lengths of a second cartridge receptacle lug(l'''), lug(l''''). As shown, a detent opening of one cartridge receptacle may be of one length det(l') that is different from a detent opening length det(l'') of the other cartridge receptacle. In some embodiments, these openings are configured to receive correspondingly sized lugs and detents (e.g., of corresponding lengths) located on corresponding cartridge connectors (as shown in, for example, Figure 6B). [0121] As shown in Figure 1J, the detent and lug openings of two different medicament receptacles P1100, P1110 may have corresponding positions. For example, the detent openings P1103, P1113 for both inlets P1100', P1110'' are located at 12 o’clock positions of the receptacles P1100, P1110, the first lug openings P1101, P1111 are at 9 o’clock, and the second lug openings P1102, P1112 are at 3 o’clock. In some variants, the lugs and detents are not in corresponding positions or only a portion of the lugs and detents are in corresponding positions. In some embodiments, even where lug openings and detent openings are in corresponding positions on separate inlets (or separate connectors), the attachment of an incorrect cartridge connector can be prevented and/or substantially hindered by providing different sizes of those equivalently positioned features. It has been found that that by providing a feature on a first receptacle (e.g., a lug opening, a detent opening, a lug, a detent, etc.) that is has a size difference of at least 15% (e.g., is 15% larger or smaller) than an equivalent feature on a second receptacle (e.g., a feature that is in the same relative position), mischanneling can be prevented and/or substantially inhibited. In certain implementations, the ratio of the length of a feature of one receptacle as compared to the length of an equivalent feature on a different receptacle is equal to or at least about: 3:1, 5:2, 2:1, 5:3, 4:3, 20:17, or ranges spanning and/or including the aforementioned ratios. [0122] In certain embodiments, as shown in Figures 3D and 6B, one or more recognition features (e.g., lugs, detents, openings configured to receive lugs or detents, etc.) may be distributed around the periphery of the inlets P1100', P1110'' or cartridge connectors C1001, C1101. For example, as shown in Figure 1J, the mid-point of one recognition feature may be positioned at the 9 o’clock position and an adjacent recognition feature may have a midpoint at 12 o’clock, thereby being separated by 90°. In some embodiments, adjacent recognition features of the inlets P1100', P1110' or connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise. As shown in Figures 1J and 6B, in some embodiments, non-adjacent recognition features of the inlets P1100', P1110' or connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise. [0123] It should be understood that, for any divot, any dimension of that divot, position of that divot, or relationship of that divot to another divot (e.g., a second divot) described herein also applies to protrusions or to relationships between protrusions. For brevity, such relationships have been shortened or omitted, as they will be readily appreciated in view of the disclosure. Likewise, as disclosed elsewhere herein, any recognition feature (e.g., notch, protrusion, etc.) described with respect to a cartridge receptacle applies to recognition features of cartridge connectors. [0124] As shown in Figures 1D-1I, in some embodiments, divots (e.g., notches, protrusion shaped openings, etc.) may open to tracks P1101', P1103', P1111', P1113' (e.g., slots, paths, etc.). In some embodiments, these paths travel and/or are positioned circumferentially within the medicament receptacles P1100, P1110. In certain variants, once a cartridge connector is inserted into the pump chamber opening, the connector is rotated to lock the cartridge connector into the receptacle. For example, in the embodiment shown in Figures 1A-1J, the connectors may each be rotated a quarter turn to lock them each into place within the pump chambers. As shown, in some embodiments, a lug of the cartridge connector in initially inserted though the lug opening P1101 and then is rotated a quarter turn to a position it under the other detent opening P1102 of the pump chamber P1100. The lug travels along the lug path to its locked position. In other embodiments, a larger lug can be positioned under the opening for a smaller lug. In some embodiments, alignment of the lug under the smaller detent or smaller lug opening inhibits removal of the cartridge connector from the pump chamber once locked since the larger lug cannot pass through the smaller detent or lug opening. As noted above, where the receptacle inlet comprises protrusions (not shown), corresponding divots and tracks are located on a corresponding cartridge connector. [0125] As would be appreciated from Figures 1E-1J, where different medicaments are used, the cartridge connectors may be configured to require a clockwise turn to lock one cartridge connector (and cartridge) in place in its corresponding receptacle and a counterclockwise turn to lock the other cartridge connector (and cartridge) in place in its corresponding receptacle. Thus, the direction of twisting is another optional indicator that allows a user to avoid mischanneling. In another embodiment, not shown, the cartridge connectors and cartridge receptacles may be configured to both allow clockwise turning to lock the cartridges in place. In another embodiment, not shown, the cartridge connectors and cartridge receptacles may be configured to both allow counterclockwise turning to lock the cartridges in place. [0126] In some embodiments, as shown in Figure 1G and 1H, the cartridge receptacles P1100, P1110 may include a first “shallow” detent cam P1103', P1113' that comprises a smaller transition angle than a second “step” detent cam P1103'', P1113'' that comprises a larger transition angle. In some embodiments, as the cartridge connector (and corresponding detent lug) is inserted into the opening of the corresponding pump chamber, the cartridge connector is rotated in a first direction to lock the connector into the pump chamber. In some embodiments, while the connector is rotated within the receptacle, the detent may abut against and then travel over the first “shallow” detent cam until the detent reaches a transition P1103''', P1113'''. As rotation continues, the detent travels over the transition P1103''', P1113''' and passed the second steep detent cam P1103'', P1113'' reaching a detent clearance configured to receive the detent. At the same time, the lugs reach the end of their tracks, stopping or impeding further twisting of the cartridge connector. The detent clearance may be bordered on one side by the second “steep” detent cam P1103'', P1113'', which would require a greater rotating force in an opposite direction to permit the detent to overcome the second cam and to remove the detent from the clearance. In some embodiments, therefore, the combination of the different detent cams causes cartridge connector to require a greater amount of force to remove and/or unlock the cartridge connector from the pump chamber once it is locked into the pump than the initial amount of force that is required to lock the cartridge connector to the pump chamber. In certain implementations, the ratio of the angle of a steep cam as compared to angle of the shallow cam is equal to or at least about: 5:1, 3:1, 5:2, 2:1, 5:3, 4:3, or ranges spanning and/or including the aforementioned ratios. In other embodiments, the steep and shallow cam can be configured to lock lugs in position (instead of or in addition to the detents). As noted above, where the receptacle inlet comprises protrusions (not shown), corresponding cams and tracks are located on a corresponding cartridge connector. [0127] In some embodiments, as shown in Figures 1F and 1G, the receptacles P1100, P1110 may comprise one or more snap-arm clearance recesses P1105a, P1105b, P1115a, P1115b (e.g., snap-arm extension recesses). In some embodiments, the snap-arm clearance recesses extend down (e.g., axially) a portion of one or more of the medicament receptacles. In some embodiments, these recesses are configured to allow and/or to provide space for the expansion of snap arms C1105a, C1105b, C1115a, C1115b (shown in Figure 6D) on cartridge connectors C1001, C1101 to engage medicament cartridges that reside in the cartridge receptacles P1100, P1110. In other words, in some embodiments, as disclosed elsewhere herein, in order to secure a medicament cartridge in the pump, one or more cartridges are first placed in the pump via a pump receptacle P1100, P1110. In some embodiments, as disclosed elsewhere herein, the cartridge connectors can then be inserted into the receptacles. As an appropriate cartridge connector receives a corresponding cartridge via the cartridge connector shroud, the snap arms expand as the snap arm passes over the periphery of the medicament cartridge cap. The snap arm recess allows this expansion for an appropriately placed connector and/or cartridge. Once the cap is past the snap arm, the snap-arm snaps back into place where lip (e.g., tooth, edge, steps, or other cap locking mechanism) engages the medicament cartridge cap. Without the snap-arm clearance, the snap-arms are unable to expand over the cap of the cartridge, preventing and/or hindering the connection of an inappropriate medicament. [0128] In certain variations, as noted elsewhere herein, the receptacles themselves may be different shapes or sizes such that they accept one type of medicament cartridge, but not another. For example, the chambers may have different diameters, shapes, or lengths such that one medicament may be received and or engaged, but not another. In some embodiments, for example, as shown in Figure 2D, the chamber diameters may be different. As disclosed elsewhere herein, the glucagon chamber may have a lip that transitions it from one diameter to another smaller diameter traveling distally from the inlet. In such an embodiment, an insulin cartridge may not be insertable into glucagon chamber. In some embodiments, the glucagon cartridge (which is smaller diameter) can go into the insulin chamber. In some embodiments, however, a stop rib in the bottom of the chamber prevents full insertion of the glucagon cartridge. It will be appreciated that, likewise, the glucagon cartridge may be larger than the insulin chamber to achieve the opposite effect. In some embodiments, the glucagon cartridge includes an insertion stop rib. In some embodiments, the stop rib prevents the glucagon cartridge from seating low enough to allow the connection within the insulin chamber. In other embodiments, the cartridges are the same diameter and other aspects disclosed herein may be implemented to avoid mischanneling. [0129] Figure 4A shows another embodiment of a pump P2000. Though for brevity not all of the features of the pump embodiment of Figure 4A may be mentioned, pump 2000 may have each feature described with respect to the embodiment of Figure 1A, except where such a feature is explicitly distinguished. Additionally, it should be recognized that, throughout this disclosure, similar and/or identical features for separate embodiments of a device or system component (e.g., pump, connectors, etc.), though not described for each different embodiment, are merely offset numerically by a factor of 1000 in the drawings (though they share hundreds, tens, and ones numerical values). For example, features of the receptacle inlet ports P2100', P2110' of the pump P2000 of Figure 4A may be common to those of the receptacle inlet ports P1100', P1110' of the pump P1000 of Figure 1A, though the features either of these inlet ports may not be detailed specifically where they are redundant of descriptions elsewhere in this disclosure. For the sake of convenience, certain features present or annotated with reference numerals in some figures and embodiments are not shown or annotated with reference numerals in other figures and embodiments. Unless the context clearly requires otherwise, these omissions should not be interpreted to mean that features omitted from the drawings of one figure could not be equally incorporated or implemented in the configurations of the disclosed methods, apparatus and systems related to or embodied in other figures. Conversely, unless the context clearly requires otherwise, it should not be assumed that the presence of certain features in some figures of the present disclosure means that the disclosed methods, apparatus and systems related to or embodied in such figures must necessarily include these features. [0130] As shown in Figures 2D-2I and 4B, in some embodiments, O-rings P1150a, P1150b, P2150a, P2150b are placed within saddles P1132, P1134, P2132, P2134. In several variants, as disclosed elsewhere herein, these O-rings provide a water resistant and/or waterproof barrier between the pump chambers P1100, P1110, P2100, P2110 and the internal area P1008, P2008 of the pump. In some embodiments, the saddles are molded within the lower portion of the pump housing P1001'', P2001'' and/or are unitary portions of the lower portion of the housing. In several embodiments, the saddles are located at the bottom of the pump chambers P1100, P1110, P2100, P2110 and/or make up a portion of the bottom of the pump chambers. In several embodiments, the saddles P1032, P1034, P2032, P2034 provide a circumferentially, inwardly extending bottom of the pump chambers P1100, P1110, P2100, P2110. In some embodiments, the saddles P1132, P1134, P2132, P2134 are configured to engage and/or hold the O-rings P1150a, P1150b, P2150a, P2150b in place. In some embodiments, the O-rings P1150a, P1150b, P2150a, P2150b are configured to seal against and/or engage two drive nuts P1142, P1144, P2142, P2144 (e.g., piston shafts). In some embodiments, a fully retracted drive nut P1142, P1144, P2142, P2144 along with the circumferentially inwardly extending saddles P1132, P1134, P2132, P2134 of the pump provide a distal end of the pump P1000, P2000 against which medicament cartridges abut when placed inside the pump P1000, P2000 (as shown in Figure 2I and 4B). [0131] As evident in Figure 2D, 2G, 2H, and 4B, though the display is removed, when fully assembled, the pump chambers P1100, P1110, P2100, P2110 are isolated and/or separated from the internal area P1008, P2008 of the pump P1000, P2000 by chamber walls P1100", P1110", P2100", P2110", the saddles P1132, P1134, P2132, P2134, the O-rings P1150a, P1150b, P2150a, P2150b, and the drive nuts P1142, P1144, P2142, P2144. In some embodiments, as evident from Figures 2D-2I and 4B, the drive nuts P1142, P1144, P2142, P2144, enter the pump receptacles P1100, P1110, P2100, P2110 via receptacle apertures P1100a, P1110a, P2100a, P2110a. In some embodiments, as disclosed elsewhere herein, the O-rings engage the drive nuts P1142, P1144, P2142, P2144 to prevent ingress of dirt, grime, water, and/or air into the pump internal area P1008, P2008 from the medicament cartridge receptacles P1100, P1110, P2100, P2110. In some embodiments, as disclosed elsewhere herein, the seal between the O-rings 1150a, P1150b, P2150a, P2150b and the drive nuts P1142, P1144, P2142, P2144 are airtight and/or watertight. In some embodiments, the seal between the O-rings 1150a, P1150b, P2150a, P2150b and the drive nuts P1142, P1144, P2142, P2144 seal the internal area of the pump from the pump chambers in an airtight and/or watertight manner. [0132] As shown in, for example, Figure 2A, in some embodiments, the motors P1060 rotate and/or move a drive gear P1071 (e.g., a pinion gear) in a gear assembly. As shown in Figure 2B, in some embodiments, each gear assembly P1070 (of which there are two pictured, a first and a second) comprises four gear components P1071, P1072, P1073, P1074 and facilitates turning of lead screws P1152, P1154 within the internal area of the pump. In some embodiments, the gear ratios of laterally adjacent and/or engaged gear wheels in the gear assembly may be equal to or at least about: 3:1, 4:1, 5:1, 8:1, or ratios spanning and/or including the aforementioned ratios. In some embodiments, as shown in Figure 2B, the gear configuration in the assembly from the motor pinion to the drive pinion on the lead screw is 4:1, 5:1, 5:1 (e.g., for a total effective gear ratio of 100:1). In several embodiments, radially adjacent and/or stacked gear configurations give the infusion pump a compact design. In several embodiments, the total effective gear ratio of the gear assembly is equal to or at least about: 200:1, 100:1, 75:1, 50:1, or ratios spanning and/or including the aforementioned ratios. [0133] In some variants, as shown, a gear assembly in the pump may comprise both small gear wheels P1071a, P1072a, P1073a and large gear wheels P1072b, P1073b, P1074b. In several embodiments, as shown in Figure 2C, the gear assembly P1070 comprises one or more stepped gear components P1072, P1073. A stepped gear comprises a larger gear wheel P1072b, P1073b and a smaller gear wheel P1072a, P1073a on the same gear component. In some embodiments, the ratio of the diameter of the larger gear wheel and smaller gear wheel of a stepped gear may be equal to or at least about: 3:1, 4:1, 5:1, 8:1, or ratios spanning and/or including the aforementioned ratios. In some embodiments, as disclosed elsewhere herein, a laterally traversing gear assembly with multiple gear steps advantageously allows the height of the pump to be reduced. Additionally, the motors can be placed laterally adjacent to their drive nut, adding to the compactness of the design. [0134] In some embodiments, the diameters of each of the large gear wheels are similar to one another. This feature advantageously allows the height of the pump to be reduced. For example, if an effective gear ratio of 100:1 is desired, a smaller diameter gear wheel can be achieved using three lateral steps (as in Figure 2C), rather than a simple single step of 100:1. In some embodiments, the diameters of each of the large gear wheels are within about 20% of one another. In some embodiments, the diameters of the large gear wheels differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values. In some embodiments, the diameter of the largest gear wheel in the gear assembly and the diameter of the second largest gear wheel in the gear assembly differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values. In some embodiments, the diameter of the largest gear wheel in the gear assembly and the diameter of the third largest gear wheel in the gear assembly (e.g., where there are two gear wheels larger than it in the gear assembly) differ by equal to or less than 40%, 30%, 20%, 10%, 5%, 0%, or ranges spanning and/or including the aforementioned values. [0135] In some embodiments, as shown in Figure 5A, the bottom section P1001''b of the lower portion P1001'' of the pump housing P1001 of the embodiment of Figure 1A has a radius of curvature P(r)f corresponding to a circle (shown with the dashed line). In some embodiments, the bottom section P1001''b is defined by the section of the pump that is the lower half of the height P(h) of the pump 1000. In some embodiments, as shown in Figure 5A, the bottom section P2001''b of the lower portion P2001'' of the pump housing P2001 of the embodiment of Figure 4A has a multiple radii of curvature P(r)fa, P(r)fb corresponding to an elliptical shape of the pump housing P2001, which is shown with the dashed line. It has been noted that, by including an elliptical shape (as with the embodiment of Figure 4A) around the receptacle inlet port P2100', increased housing strength is achieved. In several embodiments, advantageously, this increased housing strength protects the pump and its components from breakage during an accidental drop (e.g., display shatter or cracking, etc.). [0136] In some variants, the increased housing strength is realized using an elliptical shape characterized by a lower radius of curvature P(r)fb and an upper radius of curvature P(r)fa. In some embodiments, increased housing strength is realized where the lower radius of curvature P(r)fb is smaller than the upper radius of curvature P(r)fa. In some embodiments, the ratio of the lower radius of curvature P(r)fb to the upper radius of curvature P(r)fa is equal to or at least about: 1:2, 2:3, 4:5, 9:10, or ratios spanning and/or including the aforementioned values. In some embodiments, an elliptical configuration adds housing material between the receptacle inlet ports P2100' and a periphery of the pump P2001 (shown by the double headed arrows of Figure 5A). O-Ring and Chambers [0137] Various embodiments include one or more boundary sealing O-rings within the pump housing. In some embodiments, the placement of the O-ring seals the medicament chamber(s) from the internal portion of the pump. In several embodiments, however, the O-ring does not seal the cartridge receptacle(s) from the environment external to the pump. Thus, in several embodiments, an internal area of the cartridge receptacles is able to equalize with any atmospheric pressure outside and/or external to the pump. On the other hand, the area internal to the pump housing is sealed from the atmosphere (e.g., in an airtight and/or watertight manner) to prevent the ingress of harmful contaminants into the pump. Some embodiments have been designed in such a way to allow a drug cartridge to match the atmospheric pressure of the patient line and infusion site. [0138] Differences in atmospheric pressures between the infusion site (e.g., an area external to the pump) and those felt at a drug cartridge sealed within an infusion pump can lead to under/over delivery of a medicament. For instance, in an embodiment where the pump cartridge chamber is sealed from the external atmosphere within the pump, the sealing of the cartridge chamber may occur at an atmospheric pressure eventually ends up being different than the atmosphere pressure of the external environment. If the patient seals the chamber at a high atmospheric pressure environment and moves to a lower pressure environment, a pressure differential may occur. In some embodiments, the pressure differential of high chamber pressure and low external pressure may force additional medicament to be distributed from the cartridge as the pressure within the pump attempts to equalize to the external pressure. By providing a pump where the cartridge receptacle may equalize with the pressure external to the pump, these or other problems may be avoided. As noted elsewhere herein, some implementations provide an infusion pump (and/or infusion system) that is water-resistant or water-proof. Therefore, in several embodiments, where the cartridge chamber and the medicament cartridges themselves are not necessarily sealed from the environment (and/or are allowed to pressure equilibrate with the external environment) and because the cartridge chamber in the infusion pump may allow air and water to pass freely around the drug cartridges, the drug cartridge chamber and drug cartridge may be made airtight and/or watertight (or impervious or substantially impervious to the effects of the environment). [0139] In some embodiments, the medicament cartridge chamber may be sealed substantially from the ingress of water (e.g., having a sealing mechanism that prevents water from infiltrating the cartridge area), but still, may allow air or gases to move through the seal to equalize the pressure differential between the infusion site and drug cartridge. In certain embodiments, the seal may be watertight but not airtight. In some embodiments, the seal provides an aperture between the cartridge connector that is sufficiently small so that the surface tension of water prevents its ingress, but does not prevent the ingress (or exiting) of air (or other gases). Cartridge Connectors [0140] As disclosed elsewhere herein, some embodiments, pertain to one or more cartridge connectors and/or a cartridge connector set (comprising cartridge connectors). In some implementations, the cartridge connector(s) (or cartridge connector set) is a part of lumen assembly (e.g., a multi-channel lumen assembly), as disclosed elsewhere herein. In some implementations, a cartridge connector (or a cartridge connector set) is a part of an ambulatory infusion system, as disclosed elsewhere herein. In some embodiments, an infusion system comprising the cartridge connector set is provided. In some embodiments, the connector set comprises a single cartridge connector. In some embodiments, the connector set comprises two, three, four, or more cartridge connectors that may be the same or different. In some embodiments, the cartridge connector set includes fluid conduits that are attached to the cartridge connectors. In some embodiments, the cartridge connector set further comprises infusion connectors that connect to an infusion set (which includes implements such as needles configured to infuse a subject with a medicament or medicaments). [0141] For brevity, in several places a connector is described as being part of and/or engageable with a multi-channel lumen assembly (having two or more lumens) or a lumen assembly, which may comprise a single channel medicament path. It should be understood that where features for a connector are described in the context of one type of assembly (e.g., multi-channel lumen assembly or a lumen assembly), those features are also applicable to the other type of assembly (e.g., a lumen assembly or a multi-channel lumen assembly). Thus, to the extent that a connector is described in communication and/or connected with a multi-channel assembly, those features may be present in a lumen assembly, and vice versa. [0142] In some implementations, the cartridge connector(s) (or cartridge connector set) is part of and/or irreversibly connected to a lumen (e.g., of the multi-channel lumen assembly, of a tail as disclosed elsewhere herein, etc.). In several embodiments, a lumen (e.g., a fluid conduit) is connected to the cartridge connector using an adhesive, sonic welding, heat staking, etc. In other embodiments, the cartridge connector(s) (or cartridge connector set) connects and/or engages a lumen of the multi-channel lumen assembly via a reversibly connectable fitting. In several embodiments, the fitting allows reversible connection (e.g., coupling and decoupling), so the connector can be engaged within the multi-channel lumen assembly providing fluidic communication between the connector and a lumen of the multi-channel lumen assembly. [0143] Figure 6A shows a cartridge connector set C1000 configured to engage the pump P1000 of Figure 1A. In some embodiments, as shown in Figures 6A and 6B, the cartridge connectors C1001, C1101 comprise a body C1002, C1102. In some embodiments, the body C1002, C1102 comprises a piercing element C1003, C1103 (e.g., a needle). In some embodiments, the piercing element is configured to pierce the septum of a medicament cartridge and/or to receive a medicament from a medicament cartridge (e.g., when the cartridge is inserted into the connector). In some embodiments, the cartridge connectors C1001, C1101 comprise a lower surface portion C1004, C1104 extending circumferentially from the needle C1003, C1103 to a skirt C1005, C1105 (e.g., axially extending side wall, shroud, etc.) of the connector. In some embodiments, the shroud extends axially away from the lower surface portion. In some embodiments, the shroud is configured to receive and fit over a portion of a medicament cartridge. [0144] Figure 6J shows an alternative embodiment of a cartridge connector C3001 configured to engage a pump (e.g., the pump P1000 of Figure 1A). In some embodiments, as shown in Figures 6J, 6K, and 6L, the cartridge connector C3001 comprises a body C3002. In some embodiments, the body C3002 comprises a piercing element C3003 (e.g., a needle). In some embodiments, the piercing element C3003 is configured to pierce the septum of a medicament cartridge and/or to receive a medicament from a medicament cartridge (e.g., when the cartridge is inserted into the connector). Though the connector C3001 of Figure 6J is shown without a second connector (which would provide a connector set), in several embodiments, this connector C3001 could be a part of a connector set (not shown). When part of a connector set, a connector C1001, C1101, C2001, C2101, C3001 can be mixed and matched with any other connector C1001, C1101, C2001, C2101, C3001, which may have one or more differing or common recognition features (as disclosed elsewhere herein) to avoid mischanneling. [0145] In some embodiments, as shown, similar to the cartridge connector set C1000 of Figure 6A, the connector C3001 comprises a lower surface portion C3004 extending circumferentially from the needle C3003 to a skirt C3005 (e.g., axially extending side wall, shroud, etc.) of the connector. In some embodiments, the shroud extends axially away from the lower surface portion. In some embodiments, the shroud is configured to receive and fit over a portion of a medicament cartridge. [0146] In several embodiments, the lower surface portion C1004, C1104, C3001 is located within the shroud C1005, C1105, C3005 and is configured to contact a cap of the medicament cartridge when the medicament cartridge is inserted into cartridge connector (e.g., within the shroud). In some embodiments, as shown, the needle C1003, C1103, C3003 extends axially from the lower surface portion C1004, C1104, C3004 within the shroud C1005, C1105, C3005. In some embodiments, the needle does not extend passed the shroud. Figures 6A, 6L, and 7A provide views of a cartridge connector shroud and skirt ring at the bottom of the shroud (e.g., distal from the lower surface portion C1004, C1104, C3004 of the connector). [0147] In some embodiments, the shroud C1005, C1105, C3005 comprises a distal end that is away from the lower surface portion C1004, C1104, C3004 of the connector C1001, C1101, C3001. In some embodiments, as shown, the distal end of the shroud C1005a, C1105a, C3005a (shown with emphasis in Figure 6A), is unbroken (e.g., lacks any spaces, gaps, is a ring) and extends circumferentially around an axis of the connector C1001A, C1101A (shown in Figure 6A). In some variants, the shroud forms an uninterrupted ring around the bottom of the cartridge connector. In some embodiments, as shown, the needle is recessed within the connector above the shroud. In some embodiments, the unbroken end of the shroud aids in proper placement of a medicament cartridge into the connector C1001, C1101, C3001. For example, if the shroud was broken (not shown), a cartridge could be inserted into the connector at an angle more easily (by expanding the shroud). If inserted at an angle and with the medicament cartridge not travelling along the axis of the cartridge connector, the piercing element of the cartridge could pierce the septum at a location that is off-center. Then, as the cartridge is inserted to a point where it abuts the lower surface C1004, C1104, C3004 the cap of the vial would become flush to the lower surface C1004, C1104, C3004 tearing and/or forming a gap at the septum where medicament could egress. In some embodiments, the skirt ring is unbroken and is configured to ensure that the cartridge connector shroud is perpendicular to the cartridge before the needle penetrates the cartridge seal. In some embodiments, non-perpendicular needle penetration has been shown to cause leakage at the seal. Additionally or alternatively, in some embodiments, a connector C1001, C1101, C3001 can comprise a bowl shape or a concavity C1004a, C1104a, C3004a on or within the lower surface C1004, C1104, C3004. As shown in Figure 6D and 6L, the concavity C1004a, C1104a, C3004a may provide a portion of the lower surface C1004, C1104, C3004 and the remainder of the lower surface C1004, C1104, C3004 may include a lip C1004b, C1104b, C3104b (e.g., configured to contact and/or abut the cap of an appropriate medicament cartridge). In some embodiments, unlike connectors lacking a bowl feature, this bowl feature puts distances the inflection point and/or the flex point of the needle from the septum. In some embodiments, this small distance from the septum allows the piercing element to flex in a manner that it can accept an incoming medicament vial without tearing or distorting the hole the needle makes in the septum. [0148] In some embodiments, the connector C1001, C1101, C3001 comprises a knob C1006, C1106, C3006. In some embodiments, as shown in Figure 1A, 6A, and 6K the knob can be of irregular shape (e.g., partially oval with a flat portion, etc.). For instance, in several embodiments, the knob comprises an upper knob portion C1006a, C1106a, C3006a that extends distally from the upper side surface portion C1006b, C1006b, C3006a of the knob C1006, C1106, C3006 at a position that is offset from a geometric center C1006b, C1006b, C3006b of the surface portion of the of the knob such that the upper knob portion closer to one side of the perimeter of the surface portion than another side. In several embodiments, the perimeter of the surface portion C1006b, C1006b, C3006b comprises a flattened portion. In several embodiments, when inserted into the pump P1000, a portion of the knob (e.g., a portion of the surface portion C1006b, C1006b, C3006b) hangs over the pump to provide a lip that gives tactile feedback that the knob is not correctly positioned and/or is not fully engaged. In some embodiments, as disclosed elsewhere herein, when twisted a quarter turn to engage the pump, the knob of the cartridge connector then aligns so that the lip is no longer present and the knob is in alignment with the pump (as shown in Figure 1A). In some implementations, the knob C1006, C1106, C3006 is in the shape of a cam and having a flattened portion C1006'a, C1106'a, C3006'a. [0149] In some implementations, the knob C1006, C1106, C3006 comprises a rib portion C1006'', C1106'', C3106'' (e.g., a ridge, a finger hold, wing, etc.). In some embodiments, the rib provides a handle making the cap more easily manipulated between the fingers. In some embodiments, as shown in Figure 6R, the knob C3006 may comprise a plurality (2, 3, or more) of ribs C3106''. In some embodiments, the knob is a protrusion or ridge extending laterally and/or radially from the upper knob portion C1006a, C1106a, C3006a. In some embodiments, the knob allows a user to grip the cartridge connector easily between the finger in the thumb to facilitate placement in the pump chamber and to facilitate locking in the chamber. In some embodiments, as noted elsewhere herein, the cartridge is locked and/or secured in the pump chamber by providing a quarter turn twist to the knob. In some embodiments, the grip ribs help the user develop the torque needed to connect the cartridge connector to the pump. In some embodiments, the detents and/or lugs give tactile feedback when the connection is made. In some embodiments, a shallow cam within the pump chamber is provided for the detent as it rotates into the connected position keeps the connection forces low. In some embodiments, a steep cam for the detent is used to cause the disconnect forces to be higher that the connection forces. This is intended to minimize inadvertent disconnection. [0150] As disclosed elsewhere herein, some embodiments provide for each of the cartridge connectors being shaped so as to provide a visual and/or tactile indication of when the cartridge connector is locked with the pump chamber. For example, in some embodiments, a knob or other physical structure on the cartridge may indicate the orientation of the cartridge and whether the cartridge is in a locked position once the cartridge is inserted into the pump chamber. Figure 6C illustrates an example of the cartridge connector providing a visual indication of when the connector is locked to the pump chamber. The depiction on the left shows cartridges inserted in, but not locked to, the pump chamber. The depiction on the right shows cartridges aligned with pump chamber after quarter turn to indicate locked state. In some embodiments, as shown in Figure 6C, the ridges may also provide visual feedback. In some embodiments, the ridges are perpendicular to the pump face when in the locked position. In this embodiment, unlike the embodiments shown in Figures 1B and 4A, both knobs of the connectors C3001, C3101 are rotated in a clockwise fashion to lock the connectors in the pump P3000. In other embodiments, the cartridge connectors and pump openings may be configured to require a clockwise turn to lock one cartridge connector (and cartridge) in place and counterclockwise turning to lock the other cartridge connector (and cartridge) in place. Thus, another indicator that allows a user to avoid mischanneling may be added. [0151] In some embodiments, as shown in Figures 6D and 6E, the knob C1106 and the body C1102 of one connector C1101 may be one piece (e.g., a molded, unitary piece). Alternatively, in some embodiments, as apparent in Figures 6D-7A, the knob C1006, C2006, C2106, C3006 and the body C1002, C2002, C2102, C3002 of a connector C1001, C2001, C2101, C3001 may be separately molded pieces fixed together (e.g., using an adhesive, sonic welding, heat staking, etc.). As shown in Figure 6E, the connector set can comprise either or both types of connectors (unitary or fixed together). Figures 6M show the knob C3006 removed from the body (not shown). As shown in Figure 6M and 6Q, the knob C3006 may comprise one or more fittings C3006x (e.g., protrusions, snap fit arms, receptacles, snap fit receptacles) that engage corresponding fittings of the knob. [0152] In some embodiments, as shown in Figures 6E-7A a connector C1001, C2001, C2101, C3001 may comprise a projection C1007, C2007, C2107, C3007 extending axially upwardly from an upper surface of the body C1008, C2008, C2108. In some embodiments, the projection C1007, C2007, C2107, C3007 comprises a fluid outlet C1007', C2007', C2107', C3007' (e.g., connected to a through-hole or passage extending radially outward from, for example, a central fluid conduit in the projection). In some embodiments, the knob C1006, C2006, C2106, C3006, comprises a receptacle section C1006', C2006', C2106', C3006'. In some embodiments, the receptacle section C1006', C2006', C2106', C3006' is configured to extend over and receive at least a portion of the projection of the body C1007, C2007, C2107, C3007. In some embodiments, the receptacle section C1006', C2006', C2106' comprises a knob inlet C1006'', C2006'', C2106'', C3006'' configured to receive the medicament a medicament that passes through the fluid outlet C1007', C2007', C2107', C3007' of the connector body C1002, C2002, C2102, C3002. In some embodiments, an interstitial space C1009, C2009, C2109, C3009 is located between the projection of the body C1007, C2007, C2107, C3007 and the receptacle section C1006', C2006', C2106', C3006' of the knob C1006, C2006, C2106, C3006. In some embodiments, a flexible membrane C1020, C2020, C2120, C3020 is located within the interstitial space C1009, C2009, C2109, C3009 and extending over at least a portion of the projection of the body C1007, C2007, C2107, C3007. In some embodiments, as disclosed elsewhere herein, the flexible membrane C1020, C2020, C2120, C3020 is configured to allow fluid to pass from the body outlet C1007', C3007' and into the knob inlet C1006'', C3006'' only after a threshold fluid pressure of the medicament is reached. [0153] As noted elsewhere herein, medicament vials having plungers are typically designed to have little or no resistance and/or friction between the plunger and the wall of the reservoir. Thus, the plunger can move and distribute medicament with very little force applied to the plunger (e.g., even by moving the cartridge, lifting the pump comprising the cartridge, etc.). This unwanted distribution is caused by the plunger lifting off the drive nut of a pump. In some embodiments, configurations described herein avoid issues with low friction plungers and/or lift-off. In some embodiments, the membrane C1020, C2020, C2120, C3020 acts as a one-way valve and/or prevents lift-off. In some embodiments, the one-way valve (e.g., check valve) allows fluid to pass only after reaching a threshold pressure (e.g., a crack pressure) at the membrane. In some embodiments, the threshold pressure needed to allow fluid flow passed the check valve is greater than any gravitationally induced hydrostatic pressure differential that might develop between the patient and the infusion system. For instance, hydrostatic pressure can develop when the infusion system is connected to a patient via the infusion base and the patient (or user) lifts the loaded pump (containing one or more medicament vial(s)) to an elevation over the infusion base. By force of gravity, the elevation of the vial pushes fluid from the vial through the conduit and into the patient via the infusion base set. The amount of hydrostatic force applied is determined by the elevation of the medicament vial over the infusion set. The amount of hydrostatic force, therefore, is usually limited by the length of the fluid conduit (which ultimately connects the medicament vial to the infusion set). In some embodiments, a standard length of the fluid conduit is about 110 cm or about 60 cm. In some embodiments, the check valve is sufficiently resilient to remain closed when a vial of medicament in the infusion system is elevated over the infusion set by a distance of at least: about 220 cm, about 110 cm, about 60 cm, values between the aforementioned values, or ranges spanning those values. In some embodiments, the check valve is designed such that the threshold pressure gradient needed to allow fluid flow passed the check valve is greater than any hydrostatic pressure differential that might arise due to any other changes in the hydrostatic pressure between the patient and the infusion system (e.g., force caused by an airplane changing elevation, a carnival ride, bungee jumping, physical activity, etc.). [0154] In some embodiments, as shown in Figures 6H, 6L, and 7B, one or more radially extending passages C1007a, C2007a, C2007b, C2107a, C2107b, C3007a, C3007b (e.g., tunnels, fluid conduits, etc.) pass through the projection C1007, C3007 terminating at a fluid outlet C1007', C3007'. In some embodiments, tunnel(s) provides a fluid path through the projection C1007, C2007, C2107, C3007 of the cartridge connector body C1002, C2002, C2102, C3002 ending at a side hole C1007', C3007' or a plurality of side holes C2007', C2107', C1007' (e.g., apertures, outlets, etc.). In some embodiments, the side hole abuts the membrane C1020, C2020, C2120, C3020. [0155] Figures 7G and 7H show views of another example of a cartridge connector including a check valve. In some embodiments, the check valve includes standoff bumps C4020a. In some embodiments, a fluid path flows from the concave side of a check valve, around a proximal end of the check valve, and towards a convex side of the check valve. In some embodiments, as shown, a modified sheath (e.g., cap feature) is provided over an entry port into the cartridge connector and under the knob. Fluid moves under the sheath via spaces made between the pictured standoff bumps (which are distributed around the sheath) the provide a path to the end of the cap feature. In some embodiments, fluid flows up the needle (from the drug cartridge). In some embodiments, the fluid abuts the sheath. In some embodiments, when sufficient fluid pressure is generated by the plunger of the cartridge pushing out the fluid, then the perimeter of the sheath opens to relieve the pressure. In some embodiments, the fluid then flows up the tube on its way to the patient. In some embodiments, the valve provides checked flow, where in the event that the fluid attempts to flow the other direction (i.e. from the tube back into the drug cartridge), the valve will remain closed stopping this flow. The check valve can be made of silicone or another material. [0156] In some embodiments, where the knob and body are unitary, the connector C1101 is configured to receive the medicament through the needle C1103 and to deliver the medicament out of the knob C1106 from the fluid outlet C1130. [0157] In some embodiments, in a connector C1001, C2001, C2101, C3001 comprising a flexible membrane C1020, C2020, C2120, C3020 the connector C1001, C2001, C2101, C3001 is configured to receive the medicament through the needle C1003, C2003, C2103, C3003 and to deliver the medicament out of the connector through a fluid outlet of the connector C1030, C2030, C2130, C3030. In some embodiments, the needle C1003, C1103, C2003, C2103, C3003 and the fluid outlet of the connector C1030, C1130, C2030, C2130, C3030 are in fluidic communication and provide a fluid path through the connector C1001, C1101, C2001, C2101, C3001. [0158] In some embodiments, as shown in Figure 7A, where more than one connector C2001, C2101 is provided, each connector may comprise a projection C2007, C2107 extending axially upwardly from an upper surface of the body C2008, C2108, a receptacle section C2006', C2106', a knob inlet C2006'', C2106'', an interstitial space C2009, C2109 located between the projection of the body and the receptacle section of the knob C2006, C2106 and a flexible membrane C2020, C2120. In some embodiments, each connector and or a plurality of connectors in a connector set may comprise a one-way valve. As shown in Figure 6I, where more than one connector C1001, C1101 is provided, a single connector may comprise a one-way valve (and not both and/or and not more than one). [0159] In some embodiments, as shown in Figures 6B and 7C, an underside of the knob C1022, C1122, C2022, C2122, C3022 may comprise one or more nubs C1021, C1121, C2021, C2121, C3022 (e.g., projections, protrusions, small lumps, protuberances, etc.). In some embodiments, these nubs are crushable and/or malleable. In some embodiments, these nubs are rigid and/or are not crushable and/or malleable. In certain embodiments, these nubs ensure and/or encourage a tight (e.g., snug, flush, space-free vibration-free, and/or rattle-free) engagement of a connector to the pump. For example, in some embodiments, as the connector is turned into place within a connector receptacle and as the lugs of the connector pass along the feature tracks P1101', P1103', P1111', P1113', the longitudinally extending threads (e.g., traveling distally down the bore) cinch the connectors closer and closer to the pump until the connectors substantially abut the upper side surface P1004 of the pump. In some embodiments, the nubs ensure that at least a portion of the connectors contact the upper side surface of the pump to hold the connectors tightly in place against the upper side surface. It has been noted that, in the absence of nubs and where space exists between the cartridge connector and the pump housing, the cartridge connector can inadvertently be pushed flush against the pump housing (e.g., at the upper side surface) which, in turn, pushes the cartridge within the pump against the drive nut, delivering a small bolus. In some embodiments, the nubs allow the connectors to mold to the upper side surface of the pump (so that each attachment and reattachment of a connector provides a flush connection without space between the pump and the cartridge connector). [0160] In some embodiments, the nubs, in combination with the detent cams (or lug cams) provide added stability to the system. Additionally, manufacturing tolerances for the cartridge connectors (which may be disposable) is increased through use of the nubs. For example, the cartridge connectors need not be manufactured to exactly conform to a particular upper surface of a pump as the nubs aid in forming a snug / tight fit between the upper surface of the pump and the cartridge connector. [0161] As shown in Figures 1D-1I, 4A, 6A-6B, 6J-6L, and 7A, recognition features P1101, P1102, P1103, P1111, P1112, P1113, C1010, C1011, C1110, C1111, C1012, C1112, C3010, C3011, C3012 may be provided and can be configured to prevent or inhibit mischannelling. As shown in Figures 6A-6B, cartridge connectors C1001, C1101 corresponding to the pump receptacles P1100, P1110, respectively, comprise corresponding protrusions C1010, C1011, C1110, C1111, C1012, C1112 (e.g., tabs, lugs, detents) to the openings of the pump chambers P1101, P1102, P1103, P1111, P1112, P1113. In some embodiments, these protrusions include lugs C1010, C1011, C1110, C1111 and/or detents C1012, C1112. Likewise, as shown for the pump 2000 of Figure 4A and in Figures 7A and 7C, cartridge connectors C2001, C2101 corresponding to the pump receptacles P2100, P2110, respectively, comprise corresponding protrusions (e.g., tabs, lugs, detents). In some embodiments, these protrusions include lugs C2010, C2011, C2110, C2111 and/or detents C2012, C2112. In some embodiments, as disclosed elsewhere herein, the protrusions (e.g., projections) are configured to mate with (e.g., slide into) corresponding openings configured to receive such projections. As shown, the features may be protruding features (e.g., protrusions, tabs, lugs, detents) configured to engage corresponding divots (e.g., apertures, pass-through spaces, detent slots, lug slots, radial notches, carve-outs, etc.) of a receptacle. These mating features facilitate attachment of and/or to prevent connection of in appropriate components. [0162] As illustrated in Figures 6B and 6J-6L, each cartridge connector may have a plurality of recognition features. In the illustrated embodiments, each connector C1001, C1101, C3001 comprises three radially extending protrusions (lugs and detents) configured to engage correspondingly shaped carve-outs of corresponding cartridge receptacles. These recognition features may be configured to engage an appropriate receptacle, to prevent or inhibit engagement of an improper cartridge connector (e.g., that is not corresponding and that lacks one or more corresponding protrusions), or both. While in the embodiment shown in Figures 6B and 6J-6L each connector has three radially extending protrusions as recognition features, in some embodiments, each connector can independently have one, two, three, four five, or more recognition features (e.g., divots and/or protrusions) configured to engage and/or receive corresponding recognitions features (e.g., protrusions and/or divots) from corresponding pump chambers. Additionally, while the cartridge connectors have been described as comprising circumferentially distributed protrusions and the pump chambers as comprising circumferentially distributed divots, the opposite configuration is also possible (where protrusions are on the cartridge connectors and divots on the receptacles). Likewise, in some embodiments, types of recognition features could be mixed and matched on a particular cartridge connector (so the connector comprises both protrusions and divots and the corresponding receptacle has corresponding divots and protrusions). In yet another variation, a cartridge connector can comprise only divots and a different cartridge connector in the same connector set can comprise only protrusions. In such an embodiment, the corresponding cartridge receptacle can comprise corresponding protrusions and a cartridge receptacle can comprise corresponding divots, respectively. [0163] In some embodiments, as shown in Figures 6B, 6J-6L, and 7C, the lugs and detents may be various different sizes (e.g., circumferential lengths, radial heights, etc.). For example, as shown in Figure 6B, a lug of one cartridge connector may be of one length lug(cl'), a second may be of a second length lug(cl''), these lengths may be different from each other and/or from the lug lengths of a second cartridge connector lug(cl'''), lug(cl''''). As shown, a detent of one cartridge connector may be of one length det(cl') that is different from a detent length det(cl'') of the other cartridge connector. In some embodiments, these lugs and detents are configured to insert into correspondingly sized (e.g., of corresponding lengths) openings located on corresponding cartridge receptacles. [0164] As shown in Figures 6B, 6J-6L, and 7C, detents and lugs of two different connectors may have corresponding positions (e.g., when the middle feature is rotated to 12 o’clock, a first lug is at 9 o’clock, a detent is at 12 o’clock, and a second lug is at 3 o’clock, etc.). In some variants, the lugs and detents are not in corresponding positions or only a portion of the lugs and detents are in corresponding positions. In some embodiments, even where lugs and detents are in corresponding positions on separate connectors, the attachment of an incorrect cartridge connector can be prevented and/or substantially hindered by providing different sizes of those equivalently positioned features. It has been found that that by providing a feature on a first connector (e.g., a lug opening, a detent opening, a lug, a detent, etc.) that is has a size difference of at least 15% (e.g., is 15% longer or shorter) than an equivalent feature on a second connector (e.g., a feature that is in the same relative position), mischanneling can be prevented and/or substantially inhibited. In certain implementations, the ratio of the length of a feature of one connector as compared to the length of an equivalent feature on a different connector is equal to or at least about: 3:1, 5:2, 2:1, 5:3, 4:3, 20:17, or ranges spanning and/or including the aforementioned ratios. [0165] In certain embodiments, as shown in Figure 6B and 6J-6K, a plurality of recognition features (e.g., lugs, detents, openings configured to receive lugs or detents, etc.) may be distributed around the periphery of cartridge connectors C1001, C1101, C3001 (e.g., circumferentially). In certain embodiments, as shown in Figure 6B and 6J-6K, a plurality of recognition features (e.g., lugs, detents, openings configured to receive lugs or detents, etc.) may be distributed around the body of the cartridge connectors C1001, C1101, C3001 (e.g., circumferentially). For example, as shown in Figure 6B, the mid-point of one recognition feature C1012 may be positioned at the 9 o’clock position and an adjacent recognition feature may have a midpoint at 12 o’clock C1011, thereby being separated by 90°. In some embodiments, adjacent recognition features of the connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise. As shown in Figure 6B, in some embodiments, non- adjacent recognition features of the connectors C1001, C1101 may be separated by values independently selected from equal to or less than about: 180°, 160°, 140°, 120°, 100°, 90°, 80°, 70°, 60°, 50°, 40°, 30°, 20°, 10°, values between the aforementioned values or otherwise. [0166] As disclosed elsewhere herein, as noted elsewhere herein, the cartridge connectors may include, instead of and/or in additional to protrusions, divots (not shown). In some embodiments, the divots may open to tracks (e.g., slots, paths, etc.). In some embodiments, as shown for the receptacle inlets elsewhere herein, these paths may travel and/or are positioned circumferentially around the connectors. In certain variants, once a cartridge connector is inserted into the pump chamber opening, the connector is rotated to lock the cartridge connector into the receptacle (as disclosed elsewhere herein). [0167] In some embodiments, as shown in Figures 7D, 7E, and 8D, the individual cartridge connector shrouds (and/or the individual medicament cartridges) may be formed to prevent attachment of the incorrect cartridge connector with the incorrect medicament cartridge. For example, as illustrated in Figure 7D, 7E, and 8D, a first cartridge connector may have a shorter skirt. In some embodiments, a second cartridge connector C1101, C2101 (e.g., a glucagon cartridge) may be formed to have a longer shroud (e.g., skirt) than the first cartridge connector C1001, C2001 (e.g., an insulin cartridge connector). In some embodiments, not shown, one connector can have a wider diameter the other a smaller diameter. In some embodiments, alternatively, a first cartridge M1001 (e.g., the insulin cartridge) may be formed to have a wider diameter than a second cartridge M1101 (e.g., the glucagon cartridge). As such, the longer shroud C2105 of the cartridge connector C2101 would abut against a larger diameter vial of the first medicament cartridge M1001; thus, preventing the snap arms and needle cannula of the glucagon cartridge connector from engaging and connecting to the insulin cartridge (see Figure 7F). In other embodiments (not shown), the shroud of the insulin cartridge is longer to avoid engaging a glucagon cartridge that may be wider than the insulin cartridge. [0168] In some embodiments, as shown in Figures 6A, 6D, and 7A, additional features of the connectors may include one or more of a needle that is recessed within the connector above the shroud. In some embodiments, this feature, and others, prevent the vial from being pressed into the connector and/or may prevent improper puncture of the vial septum. In some embodiments, the needle recessed within the shroud makes the needle touchproof, avoiding pricks of the finger or other parts of the user’s body. [0169] In some embodiments, as disclosed elsewhere herein, the connector set comprises one or more cartridge connectors that couple the fluid conduits (shown in Figures 8A and 8B) to the medicament reservoirs. In some variants of the system, as disclosed elsewhere herein, the reservoirs (or reservoir) are located in (and/or can be placed in) a pumping device configured to distribute the medicament from the reservoirs (or reservoir) to the conduit, thereby supplying the system with medicaments. In some embodiments, the fluid conduits provide separate pathways that terminate at designated delivery members (e.g., needles, cannulas, etc.) within the base, thereby enabling independent delivery (e.g., subcutaneous or otherwise) of medicaments separately. In some embodiments, as disclosed elsewhere herein, the fluid conduits (e.g., of the lumen assembly) may be permanently and/or irreversibly affixed to the cartridge connectors. [0170] Alternatively, as shown in Figures 7I and 7J, one or more connectors may be provided with fittings C1150, C3050 that allow disconnection and reconnection of the connector C1101, C3001 with the lumen assembly (partially shown) via a corresponding fitting T1150 located on a fluid conduit T1101 of the lumen assembly (e.g., multi-channel lumen assembly). In several embodiments, either or both of the connector C3001 and the fluid conduit T1101 attachments can be closeable or resealable male or female fittings (e.g., connectors), such as a resealable female luer connector T1150 and a resealable male luer connector C1150, C3050 with a male protrusion C1151, C3051 as the fluid outlet C1130, C3030, as shown. In several embodiments, as shown, the connector C1101, C3001 may comprise the male fitting C1150, C3150 and the fluid conduit T1101 of the multi-channel lumen assembly may comprise the female fitting T1150. In other embodiments, not shown, the connector may comprise the female fitting and the fluid conduit of the multi-channel lumen assembly may comprise the male fitting. [0171] As shown in Figure 7I, the connector C1101 may comprise a tail C1160 (e.g., a length of fluid conduit) that extends from and is in fluidic communication with the connector C1101. In several embodiments, the tail C1160 is a length of fluid conduit (e.g., a channel, lumen, etc.) that terminates at the fitting C1150 providing fluidic communication between the connector C1101 and the fitting C1150. Alternatively, as shown in Figure 7J, the fitting C3050 may comprise a portion of the upper knob portion C3006a of the knob C3006. [0172] In some embodiments, a fitting of the fluid conduit T1101 and/or of the connector C1140, C3050 can include an ISO 594-compliant luer taper. In some embodiments, as shown in Figures 7I and 7J, the fitting may comprise a shroud C1153, C3053 (e.g., a skirt) that is threaded C1152, C3052 that is configured to receive a corresponding feature T1153 (e.g., threading, a thread, a lip, etc.) of the fluid conduit T1101. In some embodiments, the fittings are not threaded. In several embodiments, the female portion is configured to snuggly receive an interfacing male portion (e.g., is snug-fit). In some embodiments, the snug fitting provides added strength and/or stability to the connection between the coupling features. In some embodiments, this strength and/or stability can beneficially prevent movement, bending, breakage, or disconnection of the coupled components. In several embodiments, as shown, the female connector T1150 may comprise cinching features T1155 (e.g., protruding wings, a textured surface, or other implements that allow the connector to be grasped) that allow the connector to be twisted using the fingers to provide a tight connection with the corresponding male C1150, C3050 connector. [0173] As disclosed elsewhere herein, in some embodiments, either or both of the fittings of the fluid conduit and the connector can include a connection structure, such as one or more threads (as shown), clasps, arms, latches, protrusions, and/or recesses, etc., that is configured to help guide, attach, and/or retain the cartridge connector to the fluid conduit. In some embodiments, the connection structure can comprise one or more disconnection- resisting features or structures configured to resist disconnection between the connector and the fluid conduit. The disconnection-resisting features(s) or structure(s) can have many different forms, such as one or more freely spinning positions or stages after connection is accomplished, one or more increased friction-inducing anti-rotation impediments, and/or one or more disconnection-resisting thread shapes. For example, in a threaded connection may include a friction-inducing impediment can comprise one or more (e.g., at least two) protrusions positioned between multiple thread turns, the one or more protrusions extending radially outwardly from the inner surface of the threading, thereby providing a region of radial space between the radially outermost surface of the protrusion and the radially outermost surface of the threading that is smaller than the radial space between the inner surface of the threading and the outermost surface of the threading. In this example of an impediment, as the threading of the fluid conduit connector is rotatably attached to the threading of the connection structure, the relative rotation of the two fittings is slowed down or resisted through increased frictional contact between the impediment and the threading of the fluid conduit connector, thereby requiring greater torque to attach the two fittings and/or requiring greater torque to detach the two fittings, which diminishes the risk of accidental disconnection. The contact between the impediment and the threading of the fluid conduit connector may cause wedging, compaction, crushing, and/or compression of either or both fittings (or structures within the fittings). Many different types of impediments can be used to resist disconnection that are different from those described and/or illustrated. [0174] A disconnection-resisting thread shape can help resist or prevent disconnection between the connector fitting and the fluid conduit fitting. For example, a helical threading with multiple thread turns can comprise a thread portion with an oversized region, and/or an outwardly flaring or outwardly tapering region. In some embodiments, the outermost diameter of a beginning thread portion can be a first diameter that is a standard size or within a standard range of sizes, such as may be specified in any applicable medical device standard (e.g., any of those mentioned elsewhere in this specification), or slightly smaller than a standard size or range of sizes. As the thread of the fluid conduit progresses around the thread of the connector, the diameter of a portion of either thread can flare or taper (e.g., outwardly to a non-standard second diameter than is larger than the first diameter and larger than the diameter or range of diameters specified in one or more applicable medical device standards). Since the fitting of the fluid conduit to which the proximal region of the connector fitting is configured to attach will typically have a standard diameter of threading, the outward taper or flare of the disconnection-resisting thread shape of the connector fitting can cause the space between the respective threads to decrease, or can cause the attachment region of the fitting of the fluid conduit to stretch by a small amount, and/or can cause the threading of the fitting of the fluid conduit to compress by a small amount. One or more of these effects can create opposing radial forces between the threading surface of the fitting of the fluid conduit and the connector, which can increase the friction between the respective surfaces and thereby resist or prevent rotational movement and decrease the risk of accidental disconnection between the two devices. Many other different types of disconnection-resisting or disconnection-preventing features can be used instead of or in addition to those illustrated and/or described in this disclosure, including one or more structures not including thread shapes or impediments, or any type of threads at all. [0175] As shown in Figures 6A-7F, in some embodiments, there are one or more snap arms C1015a, C1015b, C2015a, C2015b, C1115a, C1115b, C2115a, C2115b, C3015a (e.g., 1, 2, 3, 4, or more) molded into the body of the cartridge connector. In some embodiments, these arms snap onto the cap M1002, M1102 (e.g., around the cap) or into the neck area M1003, M1103 of a drug cartridge when the cartridge connector is attached. In some embodiments, the snap-arm comprises a lip (e.g., a tooth, ridge, etc.) configured to engage the cap and/or neck of a cartridge. In some embodiments, these snap arms are in a position that ensures the cartridge is extracted from the pump when the cartridge connector is disconnected. In some embodiments, without this connection, the cartridge could be stuck in the pump by the forces on the Plunger/Pump connection. As shown, the longer skirt of a cartridge connector (e.g., glucagon) will hit a larger diameter cartridge (e.g., insulin) preventing the snap connection of the snap arms. In some embodiments, the first medicament cartridge is configured to receive insulin. In some embodiments, the second medicament cartridge is configured to receive glucagon. In some embodiments, the cartridge connector cannot rotate into the locked position within a pump if the cartridge snaps are not closed. In some embodiments, as shown, there are one or more snap arms (1, 2, 3, 4, or more) molded into the body section. In some embodiments, these arms snap onto the cap of the drug cartridge when the cartridge connector is attached. In some embodiments, a recognition feature of the second cartridge connector (e.g., the skirt ring, snap arms, etc.) is configured to block attachment of the second cartridge connector within the first pump receptacle. In some embodiments, a recognition feature of the first cartridge connector is configured to block attachment of the first cartridge connector within the second pump receptacle. [0176] In some embodiments, as shown in Figures 7F, 8A, 8B, and 8D-8E, features of a cartridge (e.g., its diameter, neck position, etc.) and/or of a connector are configured to block engagement of an improper cartridge with an improper connector. In some embodiments, features of a second cartridge M1101 (e.g., its diameter, neck position, etc.) are configured to block engagement of the second cartridge M1101 with a first connector C1001, C2001. In some embodiments, the first cartridge M1001 is configured to interact with the first cartridge connector C1001, C2001 and/or not the second cartridge connector C1101, C2101. In some embodiments, the second cartridge M1101 is configured to interact with the second cartridge connector C1101, C2101 and/or not the first cartridge connector C1001, C2001. In some embodiments, features of the cartridges (e.g., diameter, neck position, cap width and length, etc.) are configured to block engagement of a non- corresponding cartridge with the incorrect cartridge connector. Figures 7F, 8A 8B, and 8D- 8E show exemplary features. As shown in Figure 8A, when properly seated in the connector, the needle C1003, C1103 of the connector C1001, C1101 pierces the septum M1004, M1104 substantially perpendicularly. [0177] Some embodiments pertain to methods of making a cartridge connector. In some embodiments, the cartridge connector is made by employing one or more of the following steps: a needle is bonded to the body; a tube is bonded to the knob; a check valve (e.g., a flapper valve) is set onto a “valve seat” of the body and/or a membrane is stretched over the connector projection; the knob and body are fixed together (e.g., sonically welded together, snapped together, glued, otherwise affixed, etc.). In some embodiments, the cartridge connector is made by a method employing one or more of the following steps (but lacking others): a needle is bonded to the body; a tube is bonded to the knob; a check valve is set onto the “valve seat” of the body and/or a membrane is stretched over the connector projection; the knob and body are fixed together. In some embodiments, the tube mounting hole in the knob may be tapered so that the tube will contact the wall around the perimeter before bottoming out in the hole. This creates a seal to prevent adhesive from running down into the check valve area when gluing the tube into the knob. In some embodiments, the cartridge connector can be made by employing one or more of the following steps: the Needle is bonded to the Body; the Tube is bonded to the Knob. Multi-Channel Lumen Assembly [0178] As disclosed elsewhere herein, some embodiments, pertain to a lumen assembly. In some embodiments, the lumen assembly comprises one or more lumens (or tubes). In some embodiments, the lumen assembly is a multi-lumen assembly comprising a plurality of tubes (e.g., 1, 2, 3, or more). In some implementations, the lumen assembly comprises a cartridge connector (or a cartridge connector set). In some implementations, the lumen assembly comprises a fitting T1150 that engages a fitting C1150, C3050 of a connector C1101, C3001 (e.g., of a cartridge connector set). In some implementations, the lumen assembly comprises an infusion site connector (or an infusion set). In some implementations, the lumen assembly is a part of an ambulatory infusion system, as disclosed elsewhere herein. In some embodiments, an infusion system comprising the lumen assembly set is provided. [0179] A lumen assembly T1000 of a multi-lumen assembly is shown in Figure 9A with the cartridge connectors, fitting(s), and/or infusion site connectors removed. The illustrated multi-channel lumen assembly includes a first tube T1001 and a second tube T1101, respectively, forming medicament passages or channels. For example, in several embodiments, the first tube T1001 forms a first medicament channel and the second tube T1101 forms a second medicament channel. In several embodiments, of the multi-channel lumen assembly, the first and second tubes comprise the first and second cartridge connectors C1001, C1101, respectively. For example, the first end portion T1001a may be configured to engage or may be fused with the first connector C1001. In several embodiments, the first end portion T1101a of the second tube T1101 may be configured to engage or may be fused with the second connector C1101. As disclosed elsewhere herein, in several embodiments, the second end portion T1001b of the first tube T1001 may be configured to engage or may be fused with a first infusion connector 2533. In several embodiments, the second end portion T1101b of the second tube T1101 may be configured to engage or may be fused with a second infusion connector 2432. In several embodiments, of the multi-channel lumen assembly, the first and second tubes comprise the first and second fitting(s) T1101, such as provided in Figures 7I and 7J. [0180] In several embodiments, the first ends of the first and second tubes, respectively, provide the infusion pump side of the multi-channel lumen assembly. For instance, the first ends may be proximally located to the cartridge connectors and distally located with reference to the infusion connectors. The second ends of the first and second tubes, respectively, may provide the infusion set side of the multi-channel lumen assembly. For instance, the second ends may be proximally located to the infusion connectors and distally located with reference to the cartridge connectors. The tubes of the multi-channel lumen assembly can be configured so as to be able to be coupled together and then, if desired, be detached or decoupled from each other. This can preferably be done repeatedly. As shown in Figure 9A, the tubes can have formed thereon mating connecting features T1010 that allow the tubes to be coupled together over at least a portion of the length of the tubes. For example, the first tube can employ a surface feature, such as a tongue-like rail portion, that is formed on and extends outwardly from the main body of the tube. The ability to repeatedly couple and decouple the tubes of the multi-channel lumen assembly allows the patient significant flexibility in using the infusion system, and especially the multi-channel lumen assembly. In several embodiments, the patient can replace one or both of the tubes as needed rather than dispose of both tubes at the same time as is required in systems where the tubes are permanently connected. In other embodiments, the tubes of the multi-channel lumen assembly may be fused and/or permanently affixed to one another. [0181] In some implementations, the lumen assembly comprises a cartridge connector (or a cartridge set) but not an infusion site connector. In some implementations, the lumen assembly comprises an infusion site connector (or an infusion set), but not a cartridge connector. In some implementations, the lumen assembly comprises an infusion site connector (or an infusion set) and one or more fittings that connect to a cartridge connector. Infusion Set [0182] As disclosed elsewhere herein, some embodiments, pertain to one or more infusion connectors, an infusion connector set, and/or an infusion base or bases (which may be called, collectively, an infusion set). In some implementations, an infusion connector (or an infusion connector set) is a part of an ambulatory infusion system, as disclosed elsewhere herein. In some embodiments, the infusion system comprises an infusion connector set and/or infusion bases and a multi-channel lumen assembly. In some embodiments, the infusion system (e.g., infusion set) comprises an infusion connector set and/or infusion bases, a multi-channel lumen assembly, and a cartridge connector set. In some embodiments, the infusion system comprises an infusion connector set and/or infusion bases and one or more of a cartridge connector set, medicament cartridges, and an infusion pump. [0183] Figures 10A-B are isometric views showing a portion of a dual- medicament infusion set. Figure 10A shows an embodiment of a dual-medicament site base inserter 2426 attached. In Figure 10B the dual-medicament site base inserter 2426 has been removed. In some embodiments involving two medicaments, the dual-medicament site base inserter 2426 couples two disjoint halves: the right site base hub 2424 (e.g., the second base, the glucagon base, etc.), and the left site base hub 2525 (e.g., the first base, the insulin base, etc.). In several embodiments, for an embodiment shown in, for example, Figure 12C, where the infusion set does not comprise two disjoint halves, the inserter is configured to insert the base of a single infusion base 3401. [0184] In some embodiments, the inserter 2426 provides a handle for the application of the dual-medicament infusion site base 2401. In some embodiments, the base 2401 includes one or more needle guards 2429, 2529. A needle guard may also be provided on the embodiment of Figure 12C. In some embodiments, the infusion set base 2401 comprises one or more release liners 2428, 2528, 3428. In some embodiments, the infusion set base 2401, 3401 comprises an adhesive 2427, 2527, 3427 (e.g., a tape, gel, rubber adhesive, etc.). In some embodiments, once the needle guard(s) 2429, 2529 and the release liner(s) 2428, 2528, 3428 have been removed and discarded, the dual-medicament site base inserter 2426, can be used to apply the dual-medicament infusion set base 2401, 3401. In several embodiments, the needle guard protects a needle (2008a, 2008b) or other delivery conduit (such as a cannula). In several embodiments, the needle (or delivery conduit terminates at an aperture that delivers a medicament into the patient. In some embodiments, the adhesive tape 2427, 2527, 3427 (e.g., adhesive layer, adhesive pad, etc.) can be used to adhere the dual-medicament infusion set 2401, 3401 to the surface of the skin. In some embodiments, after insertion, the dual-medicament site base inserter 2426 is disposable and is removed by activating the two living hinges 2436, 2536 and sliding the dual-medicament site base inserter 2426 out of the retention slots 2430, 2530 (shown in Figure 12B) to reveal the two posts 2431, 2531 that are part of docking stations 2005, 2105 that are now ready to accept site connectors (see Figures 11A-B). In some embodiments, as shown in Figure 10B, the posts 2431, 2531 are asymmetric. In some embodiments, the infusion set inserter 2426 is reusable and can be reattached to the site base hubs 2424, 2525, 3424. [0185] In some embodiments, the infusion set includes a connector cover 2434. Figure 11A is an isometric view showing the dual-medicament infusion site connectors 2432, 2533 with a dual-medicament site connector cover 2434 attached. In some embodiments, as shown, fluid conduits from the cartridge connectors may be attached to the infusion site connectors. [0186] Figure 11B shows the dual-medicament infusion site connectors after the dual-medicament site connector cover 2434 has been removed. In some embodiments, the dual-medicament site connector cover 2434 couples the two disjoint halves: the second site connector 2432, and the first site connector 2533. In some embodiments, the site connector cover 2434 protects the site connectors 2432, 2533 from exposure (e.g., to dust, dirt, abrasion, physical damage, etc.) when they are not connected to the dual-medicament infusion site base 2401 (shown in Figure 10A). In some embodiments, the first site connector 2533 can be disconnected from the dual-medicament site connector cover 2434 by activating the living hinge 2536 to release the retention clip 2535 and then sliding the first site connector 2533 out of the retention slot 2530 (shown in Figure 12B). Disconnection of the first site connector 2533 from the dual-medicament site connector cover 2434 reveals the alignment posts 2539 and the asymmetric post receptacle 2538 which mate with corresponding features on the left site base hub 2525 (shown in Figure 10B). The same procedure can be used to disconnect the second site connector 2432 from the dual- medicament site connector cover 2434, using corresponding features and similarly tens-place enumerated features (e.g., 2436 corresponds to 2536). The order of disconnection from the dual-medicament site connector cover 2434 and reconnection to the dual-medicament infusion site set base 2401 is arbitrary. [0187] In some embodiments, alternatively and as disclosed elsewhere herein, the infusion of two different hormones can be accomplished using a single infusion site or through an infusion set comprising a single infusion base, as shown in, for example, Figures 12C-12I. In some embodiments, where a single infusion base is used, the design beneficially lowers the amount of injection sites or the amount of bases attached to the skin. In some embodiments, as shown in Figure 12C-12G, the infusion set utilizes a plastic cannula design for the primary hormone and a steel needle site design for the secondary hormone. In some embodiments, as shown in Figure 12H, the infusion set utilizes a plastic cannulas for the primary hormone and the secondary hormone. In some embodiments, as shown in Figure 12I, the infusion set utilizes a dual lumen cannula, one lumen for the primary hormone and the secondary hormone. In some embodiments, the infusion site base 3401 comprises a hub 3424. In some embodiments, the hub comprises an upper surface 3402, a bottom surface 3403, and a side surface 3404. In some embodiments, the side surface may comprises multiple perimeter surfaces (e.g., 1, 2, 3, 4, or more). In some embodiments, the hub comprises a first docking station 3005 comprising a coupling feature and a port (which are engaged in Figures 12C-12F and therefore not visible. In some embodiments, the first docking station 3005 being configured to receive a first infusion connector 3005a and to couple to it to the hub via the coupling feature of the first docking station. [0188] In several embodiments, the hub comprises a second docking station 3006. In several embodiments, the second docking station 3006 comprising a coupling feature and a port 3007. In several embodiments, the port 3007 comprises a septum 3010a. In several embodiments, the septum 3010a is configured to be punctured by a piercing element 3008b, 3008d of an infusion connector 3006a (e.g., a second infusion connector) of the infusion set (as shown in Figure 12G and 12I). In several embodiments, the second docking station 3006 is configured to receive a second infusion connector 3006a and to couple to it to the hub 3424 via the coupling feature of the second docking station. As disclosed elsewhere herein, the infusion connector 3006a may have features common with other site connectors disclosed elsewhere herein. For example, the first infusion connector may include an alignment post and a post receptacle which mate with corresponding features on the base hub. [0189] In several embodiments, as shown in Figure 12D and 12E, infusion set 3401 comprises a delivery conduit. In several embodiments, the delivery conduit is a coaxial delivery conduit 3008 extending distally from the hub 3424 and passed the adhesive 3427. In several embodiments, as shown in Figures 12D and 12E, the coaxial delivery conduit 3008 comprises a first tubular member 3008a having a first lumen and a second tubular member 3008b comprising a second lumen. In several embodiments, as shown in Figure 12A, the delivery conduit may comprise two separate tubular members (e.g., tubular delivery members) that are provided on different infusion bases. In several embodiments, as shown in Figures 12C-12I, the delivery conduit may be provided on a single infusion base and the delivery conduit may or may not be coaxial). [0190] In several embodiments, a tubular delivery member can comprise metal (e.g., stainless steel, etc.), polymer (e.g., plastic, polyurethane, Teflon, biocompatible polymer materials, etc.), or other suitable materials for delivering medicine to a patient. In several embodiments, the tubular delivery member is configured to delivery medicine to a patient transdermally, intradermally, subcutaneously, intramuscularly, intravenously, etc. [0191] In several embodiments, where two tubular delivery members together provide the delivery conduit, the tubular delivery members may be the same or different materials. For example, one tubular member may be a rigid material and the other may be flexible material. In other embodiments, where two tubular members together provide the delivery conduit, both may be made out of and/or comprise a flexible material (e.g., soft catheters). In other embodiments, where two tubular members together provide the delivery conduit, both may be made out of and/or comprise a rigid material. In several embodiments, one delivery member may be housed (e.g., partially or completely) in a second delivery member (e.g., having at least a portion that is coaxial). In other embodiments, a first and a second deliver member may be separate from one another (e.g., lacking a coaxial portion). [0192] In several embodiments, where two tubular members together provide the delivery conduit and both tubular members are flexible, the flexible material for each tubular member may be the same or different. For instance, an outer tubular member (e.g., in a coaxial arrangement) may be made of a nonstick material (e.g., Teflon, etc.) to aid in placement within the patient. An inner tubular member may be another material selected for its biocompatibility. Likewise, in several embodiments, where both tubular members are rigid, the rigid material for each tubular member may be the same or different. Alternative configurations are envisioned, as will be appreciated by the disclosure provided herein. [0193] In several embodiments, as disclosed elsewhere herein, a delivery conduit may be rigid (e.g., a metal, a rigid plastic, etc.) or flexible (e.g., a soft plastic or polymeric material, etc.). In several embodiments, where the first and second tubular member are rigid, they may act as piercing elements during insertion into the skin by an infusion set inserter. In other embodiments, the first tubular member and the second tubular member are flexible (e.g., flexible cannulae). In several embodiments, where both the first and second tubular member are flexible, an inserter having one or more piercing elements may be used to insert the tubular members into the patient. [0194] As disclosed elsewhere herein, in several embodiments, a coaxial delivery conduit may be provided. In several embodiments, as shown in Figures 12E-12H, the coaxial delivery conduit 3008 comprises a first tubular member 3008a having a first lumen and a second tubular member 3008b comprising a second lumen. The first and second lumens may terminate at first and second apertures 3008a*, 3008b*, respectively. In several embodiments, as shown, the second tubular member 3008b is disposed at least partially within the first lumen of the first tubular member 3008a of the coaxial delivery conduit. In several embodiments, as shown in Figure 12G, the first lumen of the first tubular member 3008a is in fluidic communication with a piercing element 3008c of the first infusion connector 3005a that enters the hub via a port of the first docking station 3005b. In several embodiments, the port of the first docking station 3005b comprises a septum 3010b that is pierced by the piercing element 3008c of the first infusion connector 3005a. In several embodiments, as shown in Figure 12G, the second lumen of the second tubular member 3008b is in fluidic communication with the port of the second docking station. In several embodiments, the second lumen of the second tubular member 3008b is a part of the second infusion connector 3006a, as shown in Figures 12D-12G. [0195] In several embodiments, as shown in Figures 12D-12I, the first docking station 3005 is located on the side surface 3404 of the hub 3424 and the second docking station 3006 may be located on an upper surface 3402 of the hub 3424. In several embodiments, the top down approach of the second infusion connector 3006a to the hub 3424, as shown in Figures 12D-12I, is referred to as piggy backing configuration. In several embodiments, the piggy backing configuration is achieved when the first infusion connector 3005a is connected to the hub via a lateral approach and the second infusion connector 3006a is connected to the hub via a port on the upper surface of the hub. In several embodiments, the piggy backing configuration makes the dual medicament infusion set more compact. In several embodiments, as shown in the piggy backing configuration, the first tube T1001 and the second tube T1101 may be positioned in line with each other. In other words, in several embodiments, the first and second tube are disposed over (and/or approximately over) and/or in line with one another (and/or approximately in line with one another). In several embodiments, this lowers the clutter associated with the infusion set, making it more compact. In several embodiments, as disclosed elsewhere herein, the first and second tube may have clips that allow them to attach together, further securing them and/or avoiding clutter associated with free tubes. In several embodiments, the first and second tube may be welded or otherwise affixed to one another. [0196] In several embodiments, the first lumen of the first tubular member 3008a is not in fluidic communication with the second lumen of the second tubular member 3008b. For example, when adhered to the body of a patient, the second tubular member 3008b may extend distally farther from the hub 3424 (e.g., and/or the base 3401 or adhesive 3427) than the first tubular member 3008a. In several embodiments, as shown in Figure 12G, the second tubular member extends distally from the hub to a distance farther from the hub than a distance to which the first tubular member extends. In other embodiments, the second lumen and the first lumen may be in fluidic communication. For example, the second tubular member terminate within the first tubular member, causing the lumens of the second tubular member to expel its contents within the first tubular member. In several embodiments, the second tubular member extends to a distance from the hub that is equal to or less than a distance to which the first tubular member extends. [0197] Alternatively, the infusion connector conduit (e.g., that leads to the infusion set and/or an infusion connector) may have a dual lumen (with a first lumen T1001* and second lumen T1101*) configuration configured to receive medicament from both a first fluid conduit (e.g., the first tube T1001) and a second fluid conduit (e.g., the second tube T1101). For instance, the first tube T1001 and second tube T1101 may come together to provide a conduit T1000* having a dual lumen. Such an embodiment is shown in Figure 12Ji and 12Jii. [0198] As shown in Figure 12Ji and 12Jii, in several embodiments, a single infusion base 4001 comprising a single base hub 4424 may be configured to engage a single infusion connector 4005a. As shown, the dual lumen connector conduit T1000* is configured to distribute the contents of each lumen T1001*, T1101* into a single delivery conduit 4008a (e.g., a tubular delivery member). The base may be adhered to the skin through an adhesive layer 4427. As will be appreciated, the dual lumen infusion connector conduit can be used with any cartridge connector provided elsewhere herein. For instance, the first and second tube of the cartridge connectors may join to provide the dual lumen tube. [0199] In several embodiments, as disclosed elsewhere herein, the first tubular member (e.g., the outer tubular member in coaxial embodiments) is flexible. In several embodiments, the first tubular member is a cannula. In several embodiments, the second tubular member (e.g., the inner tubular member in coaxial embodiments) is flexible. In several embodiments, the second tubular member is a cannula. Figure 12H shows an embodiment of a dual medicament system with a dual cannula where both tubular members 3008a, 3008b may be flexible. Alternatively, in several embodiments, the first tubular member may be rigid and/or the second tubular member may be rigid. In several embodiments, the first tubular member is a piercing element (e.g., a steel piercing element, needle, etc.). In several embodiments, the second tubular member is a piercing element (e.g., a steel piercing element, needle, etc.). In several embodiments, the first tubular member may be flexible and the second tubular member may be rigid. [0200] In several embodiments, as disclosed elsewhere herein and as shown in Figure 12G and 12H, the second tubular member 3008b may be longer than the first tubular member 3008a. In several embodiments, length may be measured as the distance a tubular member extends away from the adhesive layer of the infusion site base. In several embodiments, alternatively or additionally, length may be measured as the distance a tubular member extends away from the hub of the infusion site base. In several embodiments, the second tubular member is substantially the same length, about the same length, or the same length as the first tubular member. In several embodiments, not shown, the first tubular member is longer than the second tubular member. In several embodiments, the ratio of the length of the first tubular member to the second tubular member is equal to or at least about: 4:1, 3:1, 2:1, 3:2, 4:3, 5:4, 6:5, 1:1, 5:6, 4:5, 3:4, 2:3, 1:3, 1:4, ratios between the aforementioned ratios, or otherwise. In several embodiments, advantageously, having the first tubular member shorter than the second tubular member distributes different medicaments from the respective tubular members in a way that the one medicament does not interfere with the activity of the other medicament. [0201] In several embodiments, as shown in Figures 12A and 12C-12Jii, for example, a tubular delivery member (e.g., the first and second tubular delivery member) may terminate at an aperture 2008a*, 2008b*, 3008a*, 3008b*, 4008*. In several embodiments, in addition to or instead of an end aperture 2008a*, 2008b*, 3008a*, 3008b*, 3009a*, 3009b*, 4008* located at the terminal end of the tubular delivery member 2008, 3008, the tubular deliver member may have lateral apertures 3008a' along the delivery member 3008a. Such embodiments are shown in Figure 12Ki, 12Kii, 12Kiii, and 12J. As shown in Figures 12Ki-iii, the apertures 3008a' allow fluid to disperse around the first tubular member 3008a. In several embodiments, where the end aperture 3008* (or other apertures) becomes occluded, the lateral apertures 3008a' allow medicine to flow in an unobstructed manner. [0202] Though not shown, in several embodiments, the lateral apertures may be sized and/or may be distributed along the first tubular member at different densities to better distribute medicine evenly and/or at desired portions along the first tubular member. For instance, where even distribution is desired along a portion of the first tubular member, the lateral apertures closest to the hub may be smaller than those farther from the hub. By having a size gradient (e.g., where the size of the lateral apertures increases farther from the hub), the larger apertures further from the hub are able to distribute medicament at a rate (or in an amount) substantially equally to apertures closer to the hub. In several embodiments, the density of apertures (e.g., the number of apertures per area of the tubular member) may increase further from the hub to allow even distribution. In several embodiments, other configurations are possible (with gradients having higher distribution closer to the hub). This configuration may be used to better avoid a medicament from interfering with the action of the other medicament. [0203] In several embodiments, as shown in Figure 12L, a tubular member may lack an end aperture and instead, the terminal end may be sealed 3008** (e.g., plugged, welded closed, etc.). In several embodiments, in such a configuration, the interaction of the first and second medicaments delivered through the first and second deliver members, respectively, is lessened and/or prevented. Thus, the therapeutic effect of the first medicament is not hindered and/or affected by delivery of the second medicament. The delivery can be varied for and optimized for appropriate hormone infusion. [0204] As shown in Figure 12M, embodiments with dual infusion bases 2424a, 2525a (such as those shown in Figures 16A-18C) may also have lateral apertures 2008a', 2008b' configured to deliver a medicament. In several embodiments, as shown in Figure 12M, the lateral apertures 2008a', 2008b' may be distributed evenly about the delivery member(s). The first and second lumens may terminate at first and second apertures 2008a*, 2008b*, respectively, or the first and second lumens may be sealed to provide distribution through the later apertures (not shown). In several embodiments, as shown in Figure 12N, the lateral delivery apertures may be located on a portion of a delivery member. As disclosed elsewhere herein, in several embodiments, the lateral delivery apertures are more densely distributed at the terminal end and less dense at the proximal end of the delivery member. As noted elsewhere herein, the apertures may be arranged as a gradient along a portion of the delivery conduits to achieve tailored distribution about the delivery conduit. In several embodiments, as shown in Figure 12N, the proximal end of a delivery member may lack lateral delivery apertures. [0205] Alternatively, in several embodiments, in a configuration with dual infusion bases, as shown in Figure 12O, or dual delivery members, a proximal end of one delivery member may lack lateral delivery apertures and a proximal end of the other delivery member may have lateral delivery apertures. In several embodiments, this configuration helps ensure delivery of medicaments (e.g., regulatory and counter-regulatory agents) in a manner that minimizes and/or lowers the likelihood of their interaction after delivery. [0206] In several embodiments, as disclosed elsewhere herein, the first tubular member may be a cannula and, as shown in Figure 12E, the second tubular member may be a rigid element (e.g., a needle, a metal tube, etc.). In several embodiments, having the second tubular member be rigid beneficially allows its insertion through the hub after the first tubular member is implanted beneath the skin. In several embodiments, during implantation of the infusion site base 3401, the first tubular member of the coaxial delivery conduit is implanted beneath the skin (e.g., by an inserted with an inserter needle that protrudes through the first tubular member). In several embodiments, the rigid tubular member can then be inserted into the first tubular member. In other embodiments, as disclosed elsewhere herein, the second tubular member and the first may both be flexible materials (e.g., such as a cannula within a cannula), as shown in Figure 12H. In several embodiments, during implantation of the infusion site base 3401, both the first and second tubular member of the coaxial delivery conduit are implanted beneath the skin (e.g., by an inserted with an inserter needle that protrudes through both cannulae). [0207] In several embodiments, where the first tubular member is inserted using the inserter and the second tubular member is introduced thereafter, the hub may include a guide that directs the second tubular member into the first tubular member (e.g., into the lumen of the first tubular member). Advantageously, where the second tubular member is rigid, the guide helps avoid tearing or puncture of the first tubular member by the second tubular member (e.g., where the first tubular member is flexible and/or where the first tubular member is not rigid). In several embodiments, the guide may be funnel shaped and/or may comprise walls that slant toward a bottom port such that the second tubular member enters the port. In several embodiments, the guide comprises a wall (or walls) that align the second tubular member at a particular angle. In several embodiments, the guide aligns the second tubular member with the mouth and/or lumen of the first tubular member as the first tubular member is in the skin. [0208] In several embodiments, the guide is also used and/or configured to position the inserter probe (e.g., a piercing element of the inserter) of the inserter. In several embodiments, as the inserter is directed and/or projected into the skin, it positions the first tubular member at a particular position (e.g., in three-dimensional space) under the skin. In several embodiments, when the inserter (and probe) is withdrawn, it leaves the first tubular member in a path determined by the alignment feature of the hub (e.g., the guide). Then, as the second tubular member is inserted through the guide, it follows the same path as the probe, and is directed into the first tubular member. In several embodiments, the guide positions the second tubular member at a particular position (e.g., in three-dimensional space) under the skin that is the same as the position as the first tubular member. In several embodiments, the second tubular member may be rigid but the end portion is blunt (e.g., rounded, not sharp, etc.) to avoid piercing the first tubular member. [0209] In several embodiments, as disclosed elsewhere herein, the second infusion connector may comprise a rigid tubular member. In several embodiments, for example, the tubular member 3008d (shown in Figure 12H) is rigid. In several embodiments, the rigid tubular member 3008d is configured to deliver a medicament to the base hub 3424 (e.g., into the base hub). In several embodiments, as shown, the rigid tubular member may be of insufficient length to span the distance between the upper surface of the hub to the bottom surface. Thus, the rigid tubular member terminates in the hub when coupled to the base via the second docking station of the hub. In several embodiments, where the second tubular member of the coaxial delivery conduit is a cannula, the rigid tubular member 3008d of the second infusion connector terminates at an aperture (and/or within) the second tubular member. Thus, in several embodiments, the second tubular member is configured to receive a medicament from the rigid tubular member of the second infusion connector. For instance, in several embodiments, the shorter tubular member of the second infusion connector 3006a distributes medicament into the second lumen of the second tubular member. [0210] In several embodiments, as shown in Figure 12I, instead of a coaxial fluid conduit, the fluid conduit may be multi-lumen (e.g., dual lumen). In several embodiments, the first lumen 3009a of the dual lumen fluid conduit is in fluidic communication with a medicament delivered by the first infusion connector. In several embodiments, the second lumen 3009b of the dual lumen fluid conduit is in fluidic communication with a medicament delivered by the second infusion connector. [0211] In several embodiments, the needle of an inserter (not shown) protrudes through the second lumen 3008b, 3009b and the base hub 3424 prior to insertion into a patient. In several embodiments, the needle of the inserter is of sufficient circumference to collapse the flexible first lumen 3008a, 3009a of the delivery conduit 3008, 3009 around the second lumen 3008b, 3009b to allow the delivery conduit 3008, 3009 to pass through the skin to an appropriate delivery depth in the patient. In several embodiments, this configuration helps prevent the first tubular member from rolling up the second tubular member upon insertion (and/or snagging on the patient upon insertion). In some embodiments, the first tubular member may be flexible but still rigid enough to avoid rolling up the second tubular member during insertion. [0212] In several embodiments, as shown in Figures 12D, 12E, and 12G, the coaxial portion of the coaxial delivery conduit is at least partially disposed in the hub. In several embodiments, as shown in Figures 12D, 12E, and 12G, at least a portion of the coaxial delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient. For example, in several embodiments, the hub comprises an aperture that extends from the port of the second docking station, through the hub, the aperture being configured to receive a delivery conduit (e.g., the second tubular member 3008b) from the second infusion connector. In several embodiments, the aperture is configured to allow the second tubular member (e.g., a piercing element of the second infusion connector) to extend through the infusion set and into patient. [0213] In other embodiments, not shown, coaxial delivery conduit is directly attached to the bottom surface of the infusion base and a portion of the coaxial conduit is not disposed within the hub. In such an embodiment, a piercing element of the second infusion connector may terminate at the proximal portion of the second tubular member. [0214] In several embodiments, the piggy backing infusion set configuration comprises features that inhibit engagement of the second infusion connector to the first docking station. In several embodiments, the second docking station comprises features that inhibit engagement of the first infusion connector to the second docking station. For example, the features of the second infusion connector may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the second docking station corresponding to the pump chamber. Alternatively, the features of the second docking station may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the second infusion connector corresponding to the pump chamber. Similarly, the features of the first infusion connector may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the first docking station corresponding to the pump chamber. Alternatively, the features of the first docking station may be protrusion-shaped openings (e.g., divots, apertures, pass-through spaces, detent slots, lug slots, radial lug or detent shaped notches, carve-outs, etc.) configured and/or shaped to receive corresponding protruding features (e.g., protrusions, tabs, lugs, detents) of the first infusion connector corresponding to the pump chamber. [0215] The depth of each lumen in the coaxial conduit can be varied for each cannula length and optimized for hormone infusion residual. [0216] Some advantages of the piggy backing system include one injection site for patient and that the patient can change needle/cannula sites asynchronously (among other advantages). For example, the patient can change the insulin site every 3 days for example, but continue to use the same glucagon site for multiple 3 day cycles. [0217] In some embodiments (as shown in Figure 17A), the infusion site connector 2632 (e.g., the first infusion site connector, as shown, or the second infusion site connector) comprises an ergonomic feature (e.g., a flared-out edge, a finger hold, a bulbous end, etc.). In some embodiments, the ergonomic feature allows the infusion site connector to be easily grasped and pulled from the infusion base. In some embodiments, as shown in Figure 17A, the infusion site connector 2632 can have a thin section and a thick section, with the thick section being located proximal (towards) the tubing, and the thin section being proximal to base connection point. In some embodiments, this design feature, similar to the ergonomic feature, allows the infusion site connector to be easily grasped by the finger tips and slid away from the infusion base. [0218] Figure 12A shows an isometric view of a complete dual-medicament infusion set 2400 including the dual- medicament infusion site base 2401 assembled with the dual-medicament infusion site connectors. In some embodiments, as shown, the infusion set comprises a second infusion assembly comprising a second base and a second connector and a first infusion assembly comprising a first base and a first connector. In some embodiments, having the bases separate prevents needle pull in a system where both needles are fixed to a single base. In some embodiments, this feature increases comfort when the infusion set is placed on an area where movement, pulling, and discomfort can occur. Figure 12B shows a cross-sectional view revealing the internal components of the dual-medicament infusion set 2400. In some embodiments, after connection of the second site connector 2432 and the first site connector 2533, to the second site base hub 2424 and the left site base hub 2525, respectively, two closed, independent, patent, and continuous fluid paths are created. In some embodiments, the fluid paths terminate at 90 degree, beveled, hollow, piercing members 2442, 2542 (stainless steel needles). In some embodiments, each fluid path can begin in many types of connections to a fluid reservoir such as luer locks or custom cartridge connectors that eventually communicate with the lumen of the tubing 301 which is bonded together with a straight, beveled, hollow, stainless steel needle 2440, 2540 and an infusion site connector 2432, 2533, respectively. In some embodiments, upon connecting an infusion site connector(s) to an infusion site base(s), the straight, beveled, hollow, stainless steel needle 2440, 2540 pierces a site base septum 2441, 2541 respectively, allowing fluid to be pushed through the 90 degree, beveled, hollow, stainless steel needle 2442, 2542 for delivery to the patient. In some embodiments, lettering (or other visual indicators) 2450, 2550 are present on the infusion set 2400. In some embodiments, for example as shown in Figure 12A, the indicators 2442, 2542 provide convenience to a user, though, in some embodiments, mis- connection of components is still mechanically prevented. In some embodiments, the 90 degree, beveled, hollow, stainless steel needle 2442, 2542 is placed using a sub-assembly consisting of itself, a soft durometer tube 2451, 2551 and the site base septum 2441, 2541 which is then secured with a plug (not shown). [0219] Figure 13A is an isometric view showing the second site base hub 2424 (shown in Figure 11B), as it would be used in the single-medicament configuration. In some embodiments, a second site base inserter 2443 can be attached as shown. Figure 12B shows the second base hub 2424 after the second site base inserter 2443 has been removed. In some embodiments, the second site base inserter 2443 provides a handle for the application of the single-medicament infusion site base hub 2424. In some embodiments, after insertion, the second site base inserter 2443 is removed by activating the living hinge 2436 and sliding the right site base inserter 2443 out of the retention slot, 2430, to reveal the asymmetric post, 2431 that is now ready to accept a site connector 2432. Although only the half of the dual- medicament infusion site base 2401 (shown in Fig. 13B) is shown, the other half 2433 could also be used in a single-medicament configuration. In some embodiments, the other half 2433 could be attached using the same strategy, but with components having uniquely pairing features, hinges, etc. [0220] Figure 14A shows an isometric view of the second site connector 2432 (shown in Figure 15), as it would be used in the single-medicament configuration, with the second site connector cover 2446. Figure 14B shows the second site connector 2432 after the second site connector cover 2446 has been removed. In some embodiments, the second site connector cover 2446 protects the second site connector 2432 from exposure (e.g., to dirt, grime, debris, physical damage from bumps, etc.) and can be removed by activating the living hinge 2436, to release the retention clip 2435 and then sliding the second site connector 2432 out of the retention slot 2430 (shown in Figure 15B). In some embodiments, disconnection of the second site connector 2432 from the second site connector cover 2446 reveals the alignment post 2439 and the asymmetric post receptacle 2438, which mate with corresponding features on the second site base hub 2424 (shown in Figure 17). Although this depiction describes only the second half of the dual-medicament infusion site connectors (shown in Figure 15), the first half could also be used in a single-medicament configuration with similarly numbered features. [0221] Figure 15A shows an isometric view of the complete single-medicament infusion set 2400’ including the single-medicament infusion site base hub 2424 assembled with the single-medicament infusion site connector 2432. Figure 15B shows a cross-sectional view revealing the internal components of the single-medicament infusion set 2400’. In some embodiments, after connection of the second site connector 2432 to the second site base hub 2424, a closed, independent, patent, and continuous fluid path is created. In some embodiments, the closed fluid path terminates in a 90 degree piercing member, 2442 (e.g., a beveled, hollow, stainless steel needle). In some embodiments, the fluid path can begin in many types of connections to a fluid reservoir such as luer locks or custom cartridge connectors that eventually communicate with the lumen of the tubing 301. In some embodiments, the tubing 301 is bonded together with a straight piercing element 2440 (e.g., a beveled, hollow, stainless steel needle) and, in this depiction, the second site connector 2432. In some embodiments, upon connecting the second site connector 2432 to the right site base hub 2424, the straight, beveled, hollow, stainless steel needle 2440 pierces the site base septum 2441, allowing fluid to be pushed through the 90 degree, beveled, hollow, stainless steel needle 2442, for delivery to the patient. In some embodiments, although this depiction is analogous only to the second half of the dual-medicament infusion set (shown in Figures 12A-B), the first half of the infusion set (e.g., the left half) could also be used in a single- medicament configuration. In some embodiments, lettering or other visual indicators 2450, 2550 are present and provide convenience to a user. In some embodiments, beside the visual indicators, mis-connection of components is still mechanically prevented. In some embodiments, the 90 degree, beveled, hollow, stainless steel needle 2442 is placed using a sub-assembly consisting of itself, a soft durometer tube 2451 and the site base septum 2441 which is then secured with a plug (not shown). [0222] Figures 16A-E show isometric views of embodiments of a dual- medicament infusion set. Figure 16A with the right site base hub 2424, connected to a right site base cover 2444. Figure 16B shows the first site base hub 2525 connected to a first site base cover 2545. Figure 16C shows the second site connector 2432 connected to a second site connector cover 2446. Figure 16D shows the first (left) site connector 2533 connected to a first (left) site connector cover 2547. Figure 16E shows the dual-medicament infusion site base 2401 connected to a dual-medicament site base cover 2448. In some embodiments, when an individual site connector must be replaced, it can be disconnected from its site base and a site base cover can be temporarily connected to the site base thereby protecting it from exposure (as in A and B) until the site connector can be replaced. In some embodiments, if both site connectors are removed together, a dual-medicament site base cover 2448 can be connected temporarily to both site bases to protect them from exposure until the site connectors can be replaced (as in E). In some embodiments, when any individual site base must be replaced, it can be disconnected from its site connector and a site connector cover is temporarily connected to the site connector thereby protecting it from exposure (as in C and D) until the site base can be replaced. In some embodiments, if both site bases are removed together, a dual-medicament site connector cover can be connected temporarily to both site connectors to protect them from exposure until the site bases can be replaced (as in Figure 11A). A single-medicament embodiment could operate in the same manner as the right site half of A and C or the left site half of B and D. [0223] In some embodiments, a single-medicament implementation of the infusion system that infuses only medicament A can use one of the two single-medicament infusion site connectors of the dual- medicament infusion site connectors. Similarly, the other single-medicament infusion site connector, which is distinct from the single-medicament infusion site connector for medicament A, can be used for a single-medicament implementation of the infusion system that infuses only medicament B. In some embodiments, asymmetric features in the dual-medicament infusion site connectors, such as any combination of asymmetric posts, asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways can be used to differentiate the single-medicament infusion site connector for medicament A from medicament B. In some embodiments, such features can also be used to ensure that a single-medicament implementation of the infusion system that infuses only medicament A uses only the medicament A chamber in the pump housing, and a single-medicament implementation of the infusion system that infuses only medicament B uses only the medicament B chamber in the pump housing. In some embodiments, in this way, the same molds used to manufacture the dual-medicament infusion site connectors will serve for the single-medicament infusion site connectors for a single-medicament implementation of the infusion system that infuses only medicament A or only medicament B. Thus, the constituent components of the dual-medicament infusion site base, dual-medicament infusion site connectors, tubing, and needle connectors, which serve a dual-medicament implementation of the infusion system, can be used to serve one of two distinct single-medicament implementations of the infusion system, one for medicament A and one for medicament B. [0224] In some embodiments, software (either integrated into the infusion system or run on an auxiliary device such as a smart- phone or tablet) can be used to configure (automatically and/or manually) the infusion system to be configured either as a dual- medicament infusion system, as a single-medicament infusion system that uses only the medicament A chamber in the pump housing, or a single-medicament infusion system that uses only the medicament B chamber in the pump housing. In some embodiments, once any of these three configurations is implemented, the dual-medicament infusion site connectors or appropriate single- medicament infusion site connectors (either pertaining to medicament A or medicament B) can be chosen to match the particular configuration. [0225] In some embodiments involving a site connector (e.g., infusion connector) or site connectors (e.g., infusion connectors), each site connector can be designed to connect to a site base by the action of at least one retention clip. Connection of a site connector to a site base allows piercing member (e.g., a straight, beveled, hollow, and/or stainless steel needle) to pierce a septum in the site base (as in Figures 12B, 12G, and 15B). In some embodiments, once the piercing member (e.g., straight, beveled, hollow, and/or stainless steel needle) in a site connector pierces the site base septum in a site base, it is brought into fluid continuity the site base (e.g., a delivery conduit of the site base). In several embodiments, the site base comprises a piercing member (e.g., beveled, hollow, stainless steel needle), which can deliver the medicament to the delivery space. In some embodiments, this arrangement creates, for each medicament, a closed, independent, patent, and continuous fluid path from the medicament reservoir to the patient (e.g., for delivery transdermally, intradermally, subcutaneously, intramuscularly, intravenously, etc.). In some embodiments, each site base can be physically independent and can connect to or disconnect from a site connector repeatedly. In other embodiments, a single site base is provided (as shown in Figures 12C-12Jii). [0226] In some embodiments involving the use of a site base, piercing elements and/or delivery conduits can be overmolded, bonded, press-fitted, glued, solvent bonded, insert molded, or otherwise attached to the site base and/or the infusion connectors. In some embodiments, as an example other than insert molding, a piercing member may be sheathed with a soft durometer tube, which is in turn press-fit into the site base septum to create a sub- assembly outside the site base. In some embodiments, this sub-assembly can then be placed into a cavity in the site base (as shown in Figures 12B, 12G, and 15B) and a plug (not shown) can be used to hold the sub-assembly firmly in place while simultaneously ensuring a fluid seal. [0227] In some embodiments, the deliver conduit may be designed to protrude from the center or near the center of a site base (e.g., infusion base). In some embodiments, this arrangement increases the likelihood that the site base will remain adhered to the surface of the skin for the entirety of its intended use. [0228] In some embodiments involving multiple medicaments where a site connector can be connected to or disconnected from a site base, the site connectors and site bases can contain features such as lettering or other visual indicators to help prevent mis- connection of a site base or a site connector to incorrect site connectors or site bases. In some embodiments, such lettering or other visual indicators (colors, etc.) can be used in addition to physical features that mechanically prevent mis-connection. In some embodiments, the lettering or other visual indicators can be raised and colored differently from the base material to enhance visibility. [0229] In some embodiments involving multiple medicaments where a site connector can be connected to or disconnected from a site base, the site connectors and the site bases can contain features such as asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways that prevent mis-connection of a site base or a site connector to incorrect site connectors or site bases. [0230] In some embodiments involving a site connector or site connectors, each site connector can be designed to connect to a site base by the action of at least one retention clip that fits into at least one retention slot. In some embodiments involving two medicaments where only one retention clip and retention slot pair is used on each site connector and site base pair, the retention clips and retention slots may be present on the medial or lateral (as in Figures 10A-12B) sides of the site connectors and site bases. If the retention clips and retention slots are present on the lateral side of one site connector and site base pair, and on the medial site of the other site connector and site base pair, convenience is afforded to the user by allowing for the same finger to activate the living hinges. In this case, mis-connection of the site connectors to incorrect site bases is still prevented by the presence of the asymmetric posts and asymmetric post receptacles. [0231] In some embodiments involving two medicaments, a right site connector and a left site connector (as in Figures 12A and 12B) comprise the dual-medicament infusion site connectors, can be physically independent, and can contain features such as asymmetric post receptacles, retention clips, alignment posts, and/or keys and keyways that prevent mis- connection of the dual-medicament infusion site connectors to a dual-medicament infusion site base. In some embodiments the site connectors and site bases are designed such that any site connector and site base pair from a multiple medicament configuration can be used individually in a single medicament configuration (as in Figures 17-19) such that the single medicament site connectors and site bases can be manufactured from the same tools as the multiple medicament site connectors and site bases. [0232] In some embodiments involving multiple medicaments, the site connectors can be supplied with one or more site connector covers that may couple all of the site connectors, certain groups of the site connectors, or none of the site connectors such that each site connector can be supplied with its own site connector cover. The site connector cover can be connected to and disconnected from the site connectors repeatedly and protects them from exposure (as in Figure 11A). Likewise, the site bases can be supplied with one or more site base covers that may couple all of the site bases, certain groups of the site bases, or none of the site bases such that each site base can be supplied with its own site base cover. The site base cover can be connected to and disconnected from the site bases repeatedly and protects them from exposure. [0233] In some embodiments involving a single medicament or multiple medicaments, as disclosed elsewhere herein, the site base or site bases can be supplied with a site base inserter that connects to the site base or site bases in the same manner as the site connectors and provides a handle for the application of site base or site bases (as in Figures 10A-21Jii). In some embodiments, the handle provided by the site base inserter may be used to apply the site base manually or to load the site base(s) into an automated insertion device, such as a spring loaded inserter. In some embodiments, in the case of multiple site bases, one or more site base inserters may couple all of the site bases, certain groups of the site bases, or none of the site bases such that each site base can be supplied with its own site base inserter. In some embodiments, removal of a site base inserter would decouple any coupled site bases. [0234] In certain variants, a single base with multiple delivery members is provided, as shown in Figures 18A-18C. In several embodiments, the base 100 comprises multiple designated delivery conduits 130, 135 (e.g., needles, cannulae, etc.). While the needles 130, 135 shown in Figure 18C are of approximately the same length, the delivery members (e.g., needles, cannulae, etc.) can be inserted to the same or different depths under the skin by using different lengths of needles (as can delivery members of other configurations of infusion bases, as disclosed herein). In some implementations, the ratio between the delivery member lengths is at least about: 1:1, 1:1.5, 1:2, 1:5, 1:10, values in between the aforementioned values, and otherwise. Moreover, the delivery members can have different shapes and profiles. In some embodiments, medicaments can separately or together be delivered transdermally, intradermally, subcutaneously, intramuscularly, or intravenously using separate delivery members (e.g., needles or cannulas). [0235] While the term subcutaneous is used in several examples throughout this disclosure, the methods described herein are applicable to any of transdermal, intradermal, subcutaneous, intramuscular, or intravenous delivery, and the use of the term subcutaneous is used in an exemplary fashion. In some embodiments, during transdermal delivery, the medicament(s) can be delivered to, for example, a surface of the skin with or without the use of a permeation enhancing agent (e.g., a solvent such as DMSO, azone, pyrrolidones, fatty acids, essential oils, terpenes, terpenoids, oxazolidinones, urea, or the like). In certain implementations, during intradermal delivery, the medicament(s) can be delivered via a delivery member (e.g., a microneedle, etc.) that penetrates the skin by less than or equal to about 8 mm, about 6 mm, about 4 mm, about 2 mm, about 1 mm, or about 0.5 mm. In certain variants, the drug is delivered by catheters 130, 135 which can be placed under into the skin using trocars. [0236] In some embodiments, cannula angles can be independently varied with respect to one another. For instance, in some embodiments, where the cannulas are at an angle of 0 ° with respect to each other, the needles that are aligned. In some embodiments, the cannulas are at angles with respect to one another that are more than about 0 °, about 5 °, about 10 °, about 15 °, about 20 °, about 30 °, or about 40 °. [0237] As shown in Figures 18A-C, in some embodiments, there is a left and a right side distribution connector 210, 220. In some embodiments, the left side distribution connector 210 (i.e., the first distribution connector) is configured to only interact with the left side of the housing 105 via design elements of the housing 105 and/or the left side distribution connector 210. Similarly, in some embodiments, the right side distribution connector 220 (i.e., the second distribution connector) is configured to only interact with the right side of the housing 105. This capacity to engage only certain features of corresponding infusion system parts helps maintain separate medicament fluid paths (because distribution connectors cannot be simply switched from one side to the other). [0238] In some embodiments, as shown in Figure 18D, the infusion connectors 210, 220 comprise tabs 212, 222. In some embodiments, the tabs 212, 222 (e.g., pads, levers, etc.) are textured (e.g., ribbed, knurled, abraded, etc.) to provide traction during depression or positioning of each of the distribution connectors 210, 220. In some embodiments, these pads allow single hand coupling and decoupling of the distribution connectors individually 210, 220 or as a set 200. This feature enables patients, even those with limited mobility and/or dexterity, to manipulate the connectors 210, 220 to engage and disengage them. In some embodiments, the pads click into place giving an auditory signal that the connectors are engaged. In some embodiments, visual verification of attachment is unnecessary. In certain variants, as shown, the tabs 212, 222 comprise connection members 214, 224 (e.g., a flange, lip, groove, detent, etc.) that engage securing apertures 114 on the housing 105 to secure the distribution connectors 210, 220. These features help tightly seal the distribution connectors 210, 220 to the housing 105. In some implementations, the tabs 212, 222 can be single- handedly be depressed to disengage the connection members 214, 224 and to release the distribution connectors 210, 220. [0239] In some implementations, as shown in Figure 18E, the base 100 comprises a projecting first fluid inlet 110 and a second fluid inlet 120. These projecting fluid inlets 110, 120 are configured to engage corresponding connection apertures of the first distribution connector 210 and the second distribution connector 220, respectively. In some embodiments, the first fluid inlet 110 and a second fluid inlet 120 are shaped differently to match apertures of the first distribution connector 210 and the second distribution connector 220, respectively. This feature can also be implemented to prevent cross channeling of medicaments. [0240] As shown in Figure 18E, in certain variants, the base 100 comprises an adhering surface 102 (adhesive tape, gel, etc.) configured to secure the infusion set to the skin of a patient. In some implementations, the base 100 comprises a support surface 104 (e.g., a foam pad) that engages the housing 105 and provides a connection point to the adhering surface 102 (e.g., a tacky foam). In some embodiments, the adhering surface 102, support surface 104, and housing 105 have apertures configured to align and to allow the needles 130, 135 to pass through. In some embodiments, an inserter can be provided to properly align the base before it is deployed. The inserter can comprise a spring loading to quickly insert the needles 130, 135 into the skin, allowing the patient (or doctor) to direct the location of the base. [0241] Also as shown in Figure 18E, in certain implementations, the distribution connectors 210, 220 are configured to receive needles 216, 226. In certain embodiments, the needles 216, 226 can be heat bonded (or heat staked, insert molded, otherwise glued, welded, or affixed) in place within fluid conduit apertures 250, 260 of the distribution connectors 210, 220 during fabrication of the distribution connectors 210, 220. In some variants, the needles 216, 226 are removable and/or replaceable. In some embodiments, as shown in Figure 18E, the first needle 216 and the second needle 226 of the distribution connectors 210, 220 are configured to pierce a first septum 112 and a second septum 122 residing within the first fluid inlet 110 and the second fluid inlet 120 of the housing 105, respectively. These septa 112, 122 can be configured to prevent unwanted leaking of medicaments when connecting and disconnecting the distribution connectors 210, 220 via the first fluid inlet 110 and the second fluid inlet 120. In some embodiments, the septa 112, 122 comprise entrance slits that allow a needle to insert through the septa without friction. This feature minimizes buckling and back pressure in the fluid conduit. Buckling and/or back pressure can cause uneven delivery of the medicaments by causing bolus deposits to form within the connector (in, for instance the conical inlet 111) or by creating void spaces within a channel. In some embodiments, as shown, securing rings 116, 126 can be used secure the septa 112, 122 in place to avoid needle or channel buckling. In some embodiments, the rings are heat staked or ultrasonically welded into the base 100. In some implementations, rings are not used and the fluid inlets are melted or otherwise affixed in place. In some embodiments, the rings are replaceable. [0242] In certain implementations, the first distribution connector 210 and the second distribution connector 220 can be removed from the housing separately. Alternatively, they can also be removed from the housing 105 simultaneously as a unit (e.g., a distribution set 200). The facile removal of the distribution connectors and the individual movability of the same help prevent cross-channeling. For instance, in certain instances, a user may wish to replace one of the distribution connectors and to leave the other in place. Given the design features and the chirality of the distribution connectors 210, 220, when replacing a faulty distribution connector, it can only be replaced by the same type of distribution connector (e.g., a first distribution connector can only be replaced by a replacement first distribution connector and not a replacement distribution connector that has the shape of the second distribution connector). [0243] In some variants, as shown in Figures 18A-18E, the first distribution connector 210 is configured to engage the second distribution connector 220 via an engaging fastener 218 (e.g., a projection, dovetail, tongue, etc.) located on the first distribution connector 210 that interacts with a fastener aperture 228 (e.g., a groove) on the second distribution connector 220. This design element further aids in preventing the misplacement of distribution connectors during replacement (because two “second” distribution connectors cannot link together and two “first” distribution connectors could physically block each other from engagement on the housing via the dovetails). In some embodiments, these features are not present and other features of the connection/housing assembly ensure proper coupling. [0244] In some embodiments, a groove and tongue can be included on an individual distribution connector. These can interact with corresponding features of an adjacent connector to provide asymmetric connectors that can only be used together in the desired specified way (thereby limiting cross-channeling). In some embodiments, the housing can comprise design elements that allow only desired interactions with infusion connectors having complementary elements. For example, as shown in Figure 18E, in some variants, the housing 105 comprises a first guide member 150 and a second guide member 160. In certain implementations, the first guide member 150 engages a corresponding first slide aperture 230 of the first distribution connector 210 and the second slide member 160 engages a corresponding second slide aperture 240 of the second distribution connector 220. In some embodiments, these members are not present and other features of the connection/housing assembly ensure proper coupling. [0245] When present, like others features described herein, the guide member/slide aperture configuration allows only the first distribution connector 210 to interact with the first fluid path and only the second distribution connector 220 to interact with the second fluid path. This is true even where the engaging fastener 218 and fastener aperture 228 are not present. For instance, the guide member/slide aperture configuration is configured in such a way as to prevent the misplacement of distribution connectors during replacement (because two “second” distribution connectors cannot link to the housing simultaneously – the slide aperture would be facing away from the slide member). Thus, this feature of the infusion system also ensures the fluid paths can be maintained and chances for cross channeling minimized. In some embodiments, where more than two medicaments are to be delivered independently, additional shapes and sizes of male and female connector configurations can be used to lock distribution connectors in place (first and second male shapes that fit into first and second female apertures, respectively). [0246] In some embodiments, the infusion pump may be equipped with a cartridge detection hardware-software system that would detect, separately, whenever each cartridge is fully loaded and secured in its corresponding pump chamber. In some embodiments, since the design described herein can ensure that only the correct medicament cartridge can be fully loaded and secured in its corresponding pump chamber, the cartridge detection system can, when functioning in conjunction with the design described herein, effectively and conclusively inform the infusion pump system of which specific medicaments are available for potential infusion. In some embodiments, the availability status of each medicament for potential infusion at any point in time would also allow the infusion pump system to set its mode of operation accordingly. In some embodiments, for example, in the case of a dual-chamber pump, the detection of both cartridges being in place would allow the infusion pump system to operate in dual-infusion mode, whereas the detection of one cartridge being in place but not the other would lead the infusion pump system to operate in a single-infusion mode that is specific to the medicament that corresponds to the cartridge that is detected to be in place. In some embodiments, this detection capability would be determined autonomously in real time, including when a cartridge is in place or out of place transiently or temporarily. [0247] In some embodiments, the infusion pump may also be equipped with a delivery occlusion hardware-software detection system that would detect, separately, whenever the fluid-delivery path associated with each cartridge is impeded or obstructed anywhere from the cartridge, all the way through the corresponding tubing, and out to the distal end of the corresponding site base. In some embodiments, since the design described herein can ensure that only the correct tubing assembly and site base can be connected to their corresponding cartridge, the occlusion detection system would, when functioning in conjunction with the design described herein, effectively and conclusively inform the infusion pump system of which specific medicaments have a patent fluid-delivery path. [0248] In some embodiments, with both cartridge and occlusion detection systems simultaneously present, the infusion pump may at any point in time conclusively determines which medicament is possible to deliver to the user. In some embodiments, the infusion pump could then autonomously set its mode of operation, as per the detection of which of the cartridges are in place along with the patency of their corresponding fluid- delivery paths. In some embodiments, in a specialized example of a dual-chamber pump that autonomously controls blood glucose levels by delivering insulin or an insulin analog, as well as a counter-regulatory agent (e.g. glucagon, a glucagon analog, or dextrose), such cartridge and occlusion detection systems, when functioning in conjunction with the design described here, would practically allow the infusion pump system to be prescribed in a particular configuration to deliver only insulin, or only the counter-regulatory agent, or both. Moreover, in some embodiments, such an implementation would also allow the dual- chamber infusion pump system to autonomously switch its mode of operation in real time whenever either delivery channel becomes unavailable for delivery (whether informed by cartridge detection, occlusion detection, or both), including in cases where channel availability may alternate in real time. In some embodiments, the cartridge and occlusion detection methods could be realized through a variety of hardware and software implementations, including, but not limited to, techniques that rely on magnetic field or electrical signal feedback in the case of cartridge detection, or techniques that rely on back pressure detection or flow sensor technology in the case of occlusion detection, to mention but a few. [0249] In some embodiments, the features described in the context of one base, connector, housing, inlet connector, inlet connector cover, medicament reservoir, or pump assembly can be mixed and matched and used in different combinations on other bases, connectors, housings, inlet connectors, inlet connector covers, collars, medicament reservoirs, or pump assemblies. For instance, any feature described above to prevent mischanneling can be deleted from or added to other embodiments. Redundant features can be added or deleted from the components of the medicament delivery systems. [0250] The examples shown here are meant to be representative of a general approach to the design of an infusion system for multiple medicaments and various connectors, tubes, and cartridges to ensure proper channeling of each medicament to the patient. The geometric shapes, sizes, orientations, locations, and number of tabs, protrusions, and features, as well as the corresponding cavities, grooves, keyways, or slots are merely meant to be examples of a much greater abundance of variations on the particular examples shown here. [0251] For instance, as described elsewhere herein, the degrees of separation between the tabs, protrusions, and features on the cap connectors and on the corresponding cavities, grooves, keyways, or slots in the pump housing, or the degrees of separation between the tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector shown here can be generalized to be placed closer together or farther apart than in the examples shown here. Additionally, the number of tabs, protrusions, and features on the cap connectors and on the corresponding cavities, grooves, keyways, or slots in the pump housing, or the number of tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector designs shown here can be generalized to one, two, three or more such features, which might have different sizes, shapes, orientations, and locations from the examples shown here. Moreover, as discussed above, the locations of the tabs, protrusions, and features on the pre-fitted collar assembly and the corresponding cavities, grooves, keyways, or slots on the cap connector designs shown here need not be limited to the neck or head (or crown) regions of the cartridge. For instance, the point of engagement between the pre-fitted collar assembly and the cap connector could alternatively occur elsewhere on the body of the cartridge, or extend over the entire length of the cartridge. In some embodiments, the tabs, protrusions, and features on the pre-fitted collar assemblies described here could instead appear directly on the surface of the cartridge (such as in the case of an injection molded cartridge), which is either pre-filled with medicament or not pre-filled with medicament. [0252] In some embodiments, the cartridges described here can either be pre- filled with medicament or not pre-filled with medicament before or after the pre-fitted collar assemblies described here are installed onto the cartridge. In the case of the latter, such cartridges can be filled with medicament sometime after the manufacturing process, including at the point of care. [0253] In some embodiments, for example in the case of a cartridge that is filled with medicament at the point of care, the cap connector might not contain a recessed needle, but rather might couple with said cartridge using a standard luer lock or other mechanism, in which the medicament flows directly from the cartridge into the tubing without first passing through a needle. In this case, the tabs, protrusions, and features on the pre-fitted collar assemblies described here would still appear on the surface of the cap connector. [0254] In some embodiments, mischanneling of medicaments can still be avoided if one cartridge is prefilled with one medicament and a second cartridge is filled at the point of care with a different medicament. So long as only one cartridge needs to be filled with medicament at the point of care, and all other cartridges are pre-filled with medicaments, the designs described here can prevent medicament mischanneling. [0255] In some embodiments, the features and components described above are applicable to reusable injection pens (e.g., insulin pens, etc.). In some embodiments, each collar, cap, input connector, etc. could be applied to prevent incorrect dosing of drugs delivered by injection pens. For example, one unique cartridge, having a first set of unique features as described above could be used to deliver long-acting insulin to a patient via a mated injection pen. Another unique cartridge, with a second set of unique features as described above could be used to deliver fast-acting or ultra-rapid insulin analogs to a patient via a different mated injection pen. As a further example, these features can be used to differentiate between more and less concentrated insulin analogs (e.g. U100, U200, or U500 insulin analogs). [0256] The medicament described above for any embodiment can include any suitable compound or drug for treating, regulating, controlling or addressing one or more conditions of the patient. While diabetes mellitus is a target, other conditions can be addressed as well (e.g., pancreatic misfunction). The medicament can include for example a regulating agent, such as insulin, for regulating the blood glucose levels in the patient and/or a counter-regulatory agent, such as glucose or glucagon, for more effective blood glucose regulation in certain circumstances. Other type of agents can be used as well. [0257] In some embodiments, an infusion system for multiple medicaments involving various needle sites, connectors, tubes, and cartridges that ensure proper channeling of each medicament to the patient is provided. In some embodiments, the infusion system comprises an infusion pump. In some embodiments, the infusion system comprises an infusion pump with two or more pump chambers. In some embodiments, the infusion system comprises cartridges that can be filled at the point of care with different medicaments (or may be pre-filled with different medicaments). In some embodiments, the infusion system comprises connectors and tubing that connect the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments. In some embodiments, each type of cartridge for each type of medicament has unique differentiating sizes, shapes, and/or geometrical features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge) that allow for unique coupling with a type of connector that itself has unique differentiating features that engage corresponding features in the pump housing and only allow for insertion of the proper cartridge into the proper pump chamber within the infusion pump. [0258] In some embodiments, the systems described above can be used for the delivery of single medicaments, or combinations of medicaments. For instance, in some embodiments, the infusion set can be used to deliver agent A (e.g., insulin), while the features of that infusion set would be incompatible with the medicament reservoir for agent B (e.g., glucagon). Alternatively, in some embodiments, the infusion set can be used to deliver agent B, while the features of that infusion set would be incompatible with the medicament reservoir for agent A. Additionally, in some embodiments, as described above, dual medicaments can be delivered without mischanneling (e.g., bi-hormonal delivery, dual drug delivery, etc.). As is apparent from the disclosure above, configurations for the delivery of a plurality of medicaments (e.g., two, three, four, or more) without mischanneling can be provided. [0259] In some embodiments, methods of making the infusion systems disclosed herein are provided. In some embodiments, various needle sites, connectors, tubes, and cartridges that ensure proper channeling of each medicament to the patient are assembled. In some embodiments, the method comprises assembling an infusion system with an infusion pump. In some embodiments, the method comprises assembling an infusion system with a pump having two or more pump chambers. In some embodiments, the method comprises assembling an infusion system with connectors and tubing that connect the cartridges to the infusion pump in such a way as to prevent mischanneling or cross-channeling of medicaments. In some embodiments, each type of cartridge for each type of medicament is assembled to have unique differentiating sizes, shapes, and/or geometrical features (either as an integral part of the cartridge or as a component attached or affixed to the cartridge) that allow for unique coupling with a type of connector that itself has unique differentiating features that engage corresponding features in the pump housing and only allow for insertion of the proper cartridge into the proper pump chamber within the infusion pump. In some embodiments, a pump housing is prepared by connecting a bezel to a lower portion of the pump. In several embodiments, a display screen is connected to the bezel. In several embodiments, one or more of the o-rings, lead screws, drive nuts, motors, power sources, and gear assemblies are added to the pump housing. In some embodiments, the body of a connector is affixed to a knob. In several embodiments, a membrane is placed between the knob and the body. In some embodiments, a needle is affixed to the body. In several embodiments, a fluid conduit is affixed to the connector. In several embodiments, a fluid conduit is affixed to an infusion site connector. [0260] Some embodiments pertain to methods of making an infusion set. In some embodiments, the infusion base is prepared (e.g., molded). In several embodiments, the first infusion connector is prepared. In several embodiments, the second infusion connector is prepared. In some embodiments, the first and/or second infusion connector is connected to the infusion base. In several embodiments, the first and/or second infusion connector is coupled to a lumen assembly (e.g., a multi-channel lumen assembly). In several embodiments, the first and/or second cartridge connector is affixed to the lumen assembly. [0261] It should be appreciated that any of the features of the cartridge connectors, pumps, and/or cartridges disclosed herein (e.g., retention lugs (shape, size, and position), detents (shape, size, and position), skirts (length and diameter), threading (e.g., different directional, such as clockwise counter clockwise), cartridge connectors (shape, size, and position), corresponding receiving portions on the pump receptacles, etc.) may be used in combination to provide multiple cartridge connectors and pumps that avoid mischanneling. Likewise, one or more of features disclosed herein for the cartridge connectors (e.g., retention lugs and detents) could instead be provided on the pump receptacle and the corresponding pump features described above (lug and detent tracks) could instead be provided on the cartridge connectors. Moreover, as disclosed elsewhere herein, the cartridge connectors, pumps, and/or cartridges disclosed herein could lack one or more features disclosed herein. [0262] Any terms generally associated with circles, such as “radius” or “radial” or “diameter” or “circumference” or “circumferential” or any derivatives or similar types of terms are intended to be used to designate any corresponding structure in any type of geometry, not just circular structures. For example, “radial” as applied to another geometric structure should be understood to refer to a direction or distance between a location corresponding to a general geometric center of such structure to a perimeter of such structure; “diameter” as applied to another geometric structure should be understood to refer to a cross sectional width of such structure; and “circumference” as applied to another geometric structure should be understood to refer to a perimeter region. Nothing in this specification or drawings should be interpreted to limit these terms to only circles or circular structures. Likewise, any terms generally associated with polygons, such as “one side,” “another side,” or any derivatives or similar types of terms are intended to be used to designate any corresponding structure in any type of geometry, not just polygonal structures. For example, a circle, an ovals, a curved structure, or a structure without vertices may have a feature that is closer to one side than another side of the circle. [0263] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. Features disclosed under one heading (such as a connector) can be used in combination with features disclosed under a different heading (an infusion set). Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. It should be noted that the use of particular terminology when describing certain features or aspects of the disclosure should not be taken to imply that the terminology is being re-defined herein to be restricted to include any specific characteristics of the features or aspects of the disclosure with which that terminology is associated.

Claims

WHAT IS CLAIMED IS: 1. An infusion site base for delivering multiple medicaments to a patient, the infusion site base comprising: a hub having an upper surface, a bottom surface, and a side surface, the hub comprising: a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple the first infusion connector to the hub via the coupling feature of the first docking station; a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple the second infusion connector to the hub via the coupling feature of the second docking station; an adhesive located below the hub and configured to adhere the hub to skin the patient; and a coaxial delivery conduit extending distally from the hub and passed the adhesive, the coaxial delivery conduit comprising: a first tubular member having a first lumen and a second tubular member comprising a second lumen, the second tubular member being disposed at least partially within the first lumen of the first tubular member of the coaxial delivery conduit; wherein the first lumen of the first tubular member is in fluidic communication with the port of the first docking station; and wherein the second lumen of the second tubular member is in fluidic communication with the port of the second docking station.
2. The infusion site base of claim 1, wherein the first docking station is located on the side surface of the hub and wherein the second docking station is located on an upper surface of the hub.
3. The infusion site base of claim 1 or 2, wherein the first lumen of the first tubular member is not in fluidic communication with the second lumen of the second tubular member.
4. The infusion site base of any one of claims 1 to 3, wherein the first tubular member is flexible and/or wherein the second tubular member is flexible.
5. The infusion site base of any one of claims 1 to 4, wherein the first tubular member is a cannula and/or wherein the second tubular member is a cannula.
6. The infusion site base of any one of claims 1 to 3, wherein the first tubular member is rigid and/or wherein the second tubular member is rigid.
7. The infusion site base of any one of claims 1 to 3, wherein the first tubular member is a needle and/or where the second tubular member is a needle.
8. The infusion site base of any one of claims 1 to 7, wherein the second tubular member extends distally from the hub to a distance farther from the hub than a distance to which the first tubular member extends.
9. The infusion site base of any one of claims 1 to 8, wherein the second tubular member extends to a distance from the hub that is equal to or less than a distance to which the first tubular member extends.
10. The infusion site base of any one of claims 1 to 9, wherein the coaxial delivery conduit is at least partially disposed in the hub.
11. The infusion site base of any one of claims 1 to 10, wherein at least a portion of the coaxial delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient.
12. An infusion site base for delivering multiple medicaments to a patient, the infusion site base comprising: a hub having a upper surface, a bottom surface, and a side surface, the hub comprising: a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple the first infusion connector via the coupling feature of the first docking station; a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple the second infusion connector via the coupling feature of the second docking station; an aperture that extends from the port of the second docking station, through the hub, the aperture being configured to receive a delivery conduit from the second infusion connector; an adhesive located below the hub and is configured to adhere the hub to skin the patient; and a delivery conduit extending distally from the hub and passed the adhesive, the delivery conduit comprising a first tubular member having a first lumen, the first lumen of the delivery conduit being in fluidic communication with the port of the first docking station via the fluid passage of the hub; wherein at least a portion of the delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient; and wherein the aperture is in fluidic communication with the first lumen.
13. The infusion site base of claim 12, wherein the first docking station is located on the side surface of the hub and wherein the second docking station is located on an upper surface of the hub.
14. The infusion site base of claim 12, wherein the first tubular member is flexible.
15. The infusion site base of claim 12, wherein the first tubular member is a cannula.
16. The infusion site base of claim 12, wherein the first tubular member is rigid.
17. The infusion site base of claim 12, wherein the first tubular member is a needle.
18. The infusion site base of any one of claims 12 to 17, wherein the aperture is configured to allow a piercing element of the second infusion connector to extend through the infusion set and into patient.
19. An infusion site base for delivering multiple medicaments to a patient, the infusion site base comprising: a hub having an upper surface, a bottom surface, and a side surface, the hub comprising: a first docking station comprising a coupling feature and a port, the first docking station being configured to receive a first infusion connector and to couple the first infusion connector to the hub via the coupling feature of the first docking station; a second docking station comprising a coupling feature and a port, the second docking station being configured to receive a second infusion connector and to couple the second infusion connector to the hub via the coupling feature of the second docking station; an adhesive located below the hub and configured to adhere the hub to skin the patient; and a dual lumen delivery conduit extending distally from the hub and passed the adhesive, the dual lumen delivery conduit comprising: a first lumen and a second lumen; wherein the first lumen is in fluidic communication with the port of the first docking station; and wherein the second lumen is in fluidic communication with the port of the second docking station.
20. The infusion site base of claim 19, wherein the first docking station is located on the side surface of the hub and wherein the second docking station is located on an upper surface of the hub.
21. The infusion site base of claim 19 or 20, wherein the first lumen is not in fluidic communication with the second lumen.
22. The infusion site base of any one of claims 19 to 21, wherein the dual lumen delivery conduit is flexible.
23. The infusion site base of any one of claims 19 to 22, wherein at least a portion of the dual lumen delivery conduit is configured to extend below a surface of the skin of the patient, when the infusion site base is adhered to a skin of the patient.
24. The infusion site base of any one of claims 1 to 23, wherein the first docking station comprises features that inhibit engagement of the second infusion connector to the first docking station.
25. The infusion site base of any one of claims 1 to 24, wherein the second docking station comprises features that inhibit engagement of the first infusion connector to the second docking station.
26. A system for delivery of multiple medicaments to a patient, the system comprising the infusion site base of any one of claims 12 to 18, the first infusion connector, and the second infusion connector; wherein the second infusion connector comprises a piercing element; and wherein, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub of the infusion site base.
27. The system of claim 26, wherein the piercing element of the second infusion connector is a needle.
28. The system of claim 26 or 27, wherein, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub and into the first tubular fluid conduit.
29. The system of claim 26 or 27, wherein, when the second infusion connector is engaged to the second docking station, the piercing element of the second infusion connector passes through the hub and is located at a position laterally disposed from the first tubular fluid conduit.
30. A system for delivery of multiple medicaments to a patient, the system comprising the infusion site base of any one of claims 1 to 25, the first infusion connector, and the second infusion connector.
31. The system of any one of claims 26 to 30, further comprising a multi-channel lumen assembly, wherein the multi-channel lumen assembly comprises the first infusion connector and second infusion connector, the multi-channel lumen assembly comprising a first fluid conduit in fluidic communication with the first infusion connector and a second fluid conduit in fluidic communication with a second infusion connector.
32. The system of claim 31, further comprising a first reservoir connector in fluidic communication with the first infusion connector via the first fluid conduit of the multi-channel lumen assembly.
33. The system of claim 31 or 32, further comprising a second reservoir connector in fluidic communication with the second infusion connector via the second fluid conduit of the multi-channel lumen assembly.
34. The system of any one of claims 31 to 33, wherein, when the first infusion connector is engaged to the first docking station and the second infusion connector is engaged to the second docking station, the second fluid conduit of the multi-channel lumen assembly is disposed over the first fluid conduit of the multi-channel lumen assembly.
35. The system of claim 31, further comprising a first fitting in fluidic communication with the first infusion connector via the first fluid conduit of the multi- channel lumen assembly, the first fitting being configured to engage with a corresponding fitting of a first cartridge connector.
36. The system of any one of claims 31, 32, or 35, further comprising a second fitting in fluidic communication with the second infusion connector via the second fluid conduit of the multi-channel lumen assembly, the second fitting being configured to engage with a corresponding fitting of a second cartridge connector.
37. An infusion set for delivering multiple medicaments to a patient, the infusion set comprising: a first infusion connector; a second infusion connector; and an infusion site base comprising: an adhesive portion configured to adhere the infusion set to skin the patient; a hub having a top surface and a bottom surface, the bottom surface of the hub being proximal to the adhesive portion of the infusion set and the top surface being distal to the adhesive portion of the infusion set, the hub comprising: a first docking station comprising a coupling feature and a port, the first docking station being configured to receive the first infusion connector and to couple to it via the coupling feature of the first docking station; a second docking station comprising a coupling feature and a port, the second docking station being configured to receive the second infusion connector and to couple to it via the coupling feature of the second docking station; a coaxial delivery conduit extending distally from the hub, the coaxial delivery conduit comprising a first tubular member having a first lumen and a second tubular member comprising a second lumen, the second tubular member being disposed at least partially within the first lumen of the first tubular member; and wherein the first lumen of the first tubular member is in fluidic communication with the port of the first docking station; wherein the coaxial delivery conduit extends distally from the adhesive portion and, when the infusion set is adhered to a skin of the patient, is configured to extend below a surface of the skin of the patient.
38. The infusion set of claim 37, wherein the first infusion connector comprises a first piercing member extending from a body of the first infusion connector infusion, the first piercing member having a lumen configured receive and to allow flow of a first medicament through the first infusion connector.
39. The infusion set of claim 37 or 38, wherein the hub comprises a side surface extending between the upper surface and lower surface, the side surface comprising the first docking station; wherein upon coupling of the first infusion to the first docking station, the first piercing member extends through the port of the first docking station to provide fluidic communication between the lumen of the first piercing member and first lumen of the coaxial delivery conduit.
40. The infusion set of claim 39, wherein the port of the first docking station comprises a first septum configured to be pierced by the first piercing member upon connection between the first infusion connector to the infusion set.
41. The infusion set of any one of claims 37 to 40, wherein the second infusion connector comprises a second piercing member extending from a body of the second infusion connector infusion, the second piercing member having a lumen configured receive and to allow flow of a second medicament through the second infusion connector.
42. The infusion set of claim 41, wherein the port of the second docking station comprises a second septum configured to be pierced by the second piercing member upon connection between the second infusion connector to the infusion set.
43. The infusion set of claim 42, wherein the upper surface of the hub comprises the second docking station; wherein upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide fluidic communication between the lumen of the second piercing member and the second lumen of the coaxial delivery conduit.
44. The infusion set of claim 42, wherein the upper surface of the hub comprises the second docking station; wherein upon coupling of the second infusion to the second docking station, the second piercing member extends through the port of the second docking station to provide the lumen of the second piercing member and the second lumen of the coaxial delivery conduit.
45. A cartridge connector comprising: a knob comprising: a surface portion having an upper side, a lower side, and a perimeter; and an upper knob portion extending distally from the upper side of the surface portion of the knob, the upper knob portion comprising an outlet port and an outlet fitting, the outlet fitting being circumferentially disposed around the outlet port, the outlet fitting being configured to engage a corresponding fitting of a fluid conduit of an infusion set such that, when the fitting of the fluid conduit is engaged to the outlet fitting, the cartridge connector and the fluid conduit of the infusion set are in fluidic communication; and a body extending distally from the lower side surface of the knob, the body comprising: a needle, a lower surface portion extending circumferentially from the needle, and a shroud extending axially away from the lower surface portion of the body and the lower side surface of the knob, the shroud being configured to engage a cap of a medicament cartridge when the medicament cartridge is inserted into the cartridge connector; wherein the lower surface portion of the body is located within the shroud; and wherein the needle extends axially within the shroud away from the lower surface portion of the body, the needle being configured to contact a medicament within the medicament cartridge when the medicament cartridge is inserted into the cartridge connector.
46. The cartridge connector of claim 45, wherein the upper knob portion comprises a length of fluid conduit extending distally from the surface portion and terminating at the outlet port and the outlet fitting of the upper knob portion.
47. The cartridge connector of claim 45 or 46, wherein the upper knob portion comprises a threaded shroud configured to engage the corresponding fitting of the fluid conduit of the infusion set.
48. The cartridge connector of any one of claims 45 to 47, wherein the outlet fitting of the of the upper knob portion comprises a male receiving region.
49. The cartridge connector of claim 48, wherein the male receiving region is a male luer.
50. The cartridge connector of claim 49, wherein the male luer comprises an ISO 594- compliant luer taper.
51. The cartridge connector of any one of claims 45 to 50, wherein the fitting of the fluid conduit of the infusion set is a female luer connector.
52. The cartridge connector of any one of claims 45 to 51, wherein the surface portion of the knob extends outward from the upper knob portion.
53. The cartridge connector of claim 52, wherein the upper knob portion extends distally from the upper side surface portion of the knob at a position that is offset from a geometric center of the surface portion of the of the knob such that the upper knob portion closer to one side of the perimeter of the surface portion than another side.
54. The cartridge connector of any one of claims 45 to 53, wherein the perimeter of the surface portion comprises a flattened portion.
55. The cartridge connector of claim 54, wherein the knob is in a shape of a cam having the flattened portion.
56. The cartridge connector of claim 54 or 55, wherein, once inserted into a pump receptacle of an infusion pump, the cartridge connector is configured to be positioned within the pump receptacle using a quarter turn that aligns the flattened portion with a corresponding flat surface of the pump to indicate to a user that the cartridge connector is correctly placed in the pump.
57. The cartridge connector of any one of claims 45 to 56, wherein the lower side of the knob extends circumferentially from the shroud of the body and wherein the lower side of the knob comprises one or more nubs.
58. The cartridge connector of claim 57, wherein the one or more nubs are configured to contact an upper side surface of an infusion pump, the one or more nubs providing one or more contact points between the lower surface of the knob and the infusion pump.
59. The cartridge connector of claim 58, wherein the nubs are deformable and are configured to deform when the cartridge connector is twisted into place within the infusion pump.
60. The cartridge connector of any one of claims 45 to 59, wherein the lower surface portion of the body comprises a bowl-shaped concavity and a surrounding lip, wherein the needle protrudes from and extends away from the bowl-shaped concavity.
61. The cartridge connector of any one of claims 45 to 60, wherein body comprises a projection extending axially upwardly from an upper surface of the body, the projection comprising a fluid outlet; wherein the body is configured to receive the medicament through the needle and to deliver the medicament out of the body from the fluid outlet of the body, the needle and the fluid outlet of the body being in fluidic communication and providing a fluid path through the body; wherein the knob comprises: a receptacle section extending upwardly into the lower side of the knob, the receptacle section configured to extend over and receive at least a portion of the projection of the body; a fluid inlet located within the receptacle section, the fluid inlet being configured to receive the medicament; and a fluid path configured to deliver the medicament to a the outlet port of the knob; wherein the connector comprises an interstitial space located between the projection of the body and the receptacle section of the knob a flexible membrane located within the interstitial space and extending over at least a portion of the projection of the body, the flexible membrane being configured to allow fluid to pass from the body outlet and into the knob inlet only after a threshold fluid pressure of the medicament is reached.
62. The cartridge connector of any one of claims 45 to 60, wherein the knob is fixed to and/or unitary with the body.
63. The cartridge connector of any one of claims 45 to 62, wherein the cartridge connector is configured to simultaneously engage the medicament cartridge and a port of an infusion pump.
64. The cartridge connector of any one of claims 45 to 63, wherein the needle of the cartridge connector is configured to pierce a septum of the cap of the first medicament cartridge.
65. The cartridge connector of any one of claims 45 to 64, wherein the shroud comprises one or more of a snap arm configured to engage the cap of the first medicament cartridge, a detent, and/or a lug.
66. A medicament connector set for delivering a single or multiple medicaments to a patient, the medicament connector set comprising the cartridge connector of any one of claims 45 to 65 as a first cartridge connector and a first fluid conduit of an infusion set.
67. The medicament connector set of claim 66, further comprising a first infusion connector in fluidic communication with the first fluid conduit.
68. A medicament connector set for delivering a single or multiple medicaments to a patient, the medicament connector set comprising the cartridge connector of any one of claims 45 to 65 as a first cartridge connector and a second cartridge connector configured to engage a second medicament cartridge, the second medicament cartridge connector comprising: a body comprising: a needle; a lower surface portion extending circumferentially from the needle; a shroud extending axially away from the lower surface portion and configured to receive and fit over a portion of a second medicament cartridge that is configured to hold a second medicament; and wherein the needle extends axially within the shroud away from the lower surface portion; and a knob connected to the body, the knob comprising a lower side extending circumferentially from the shroud of the body, the knob comprising a fluid outlet configured to deliver the second medicament to a position outside the cartridge connector.
69. The connector set of claim 68, wherein the second cartridge connector is configured to engage a second port of the infusion pump the second port being different than the first port of the infusion pump.
70. The connector set of claim 68 or 69, wherein the shroud of the second cartridge connector comprises one or more of a snap arm configured to engage the cap of the second medicament cartridge, a detent, and/or a lug.
71. The connector set of claim 70, wherein one or more of the snap arm, the detent, and/or the lug of the first cartridge connector is different than the snap arm, the detent, and/or the lug of the second cartridge connector.
72. The connector set of any one of claims 68 to 71, wherein the first cartridge connector is configured to not engage the second medicament cartridge and/or wherein the second cartridge connector is configured to not engage the first medicament cartridge.
73. The connector set of any one of claims 68 to 72, wherein the first cartridge connector is configured to not engage the second port of the infusion pump and/or wherein the second cartridge connector is configured to not engage the first port of the infusion pump.
74. An infusion system comprising the connector set of any one of claims 66 to 73 and the infusion pump.
75. An infusion system comprising the connector of any one of claims 45 to 65 and the infusion site base of any one of claims 1 to 25.
76. A medicament connector set for delivering a single or multiple medicaments to a patient, the medicament connector set comprising the cartridge connector of any one of claims 45 to 65 as a first cartridge connector and a first fluid conduit configured to receive the first medicament from the first cartridge connector.
77. The medicament connector set of claim 76, further comprising a first infusion connector in fluidic communication with the first fluid conduit.
78. The system of claim 32 or 33, wherein the first reservoir connector is the connector of any one of claims 45 to 65.
PCT/US2022/012795 2020-12-07 2022-01-18 Ambulatory device and components thereof WO2022159393A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
PCT/US2022/017368 WO2022178447A1 (en) 2021-02-19 2022-02-22 Medicament pumps with systems and methods for improving user experience
US17/654,776 US20220199218A1 (en) 2020-12-07 2022-03-14 Ambulatory medicament pump with integrated medicament ordering interface
US17/654,913 US20220208331A1 (en) 2020-12-07 2022-03-15 Remote modification of therapy delivered by ambulatory medicament pump
US17/655,122 US20220208370A1 (en) 2020-12-07 2022-03-16 Remote modification of therapy delivered by ambulatory medicament pump
US17/656,356 US11515027B2 (en) 2020-12-07 2022-03-24 Cloud-connected ambulatory pump integration
US17/656,345 US20220223251A1 (en) 2020-12-07 2022-03-24 Cloud-connected ambulatory pump integration
PCT/US2022/071308 WO2022204705A1 (en) 2021-03-25 2022-03-24 Emergency medicament dose control
US17/656,849 US20220222734A1 (en) 2020-12-21 2022-03-28 Cloud-connected ambulatory pump integration
US17/657,105 US20220218904A1 (en) 2020-12-07 2022-03-29 Cloud-connected ambulatory pump integration
US17/657,263 US20220223273A1 (en) 2020-12-07 2022-03-30 Cloud-connected ambulatory pump integration
US17/657,547 US20220223252A1 (en) 2020-12-07 2022-03-31 Aggregate reporting of glucose level control system data
US17/657,607 US20220218905A1 (en) 2020-12-07 2022-03-31 Ambulatory medicament pump voice operation
US17/657,612 US11581080B2 (en) 2020-12-07 2022-03-31 Ambulatory medicament pump voice operation
US17/882,469 US20230166035A1 (en) 2021-03-25 2022-08-05 Emergency medicament dose control

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163139210P 2021-01-19 2021-01-19
US63/139,210 2021-01-19
US202163238670P 2021-08-30 2021-08-30
US63/238,670 2021-08-30

Related Parent Applications (2)

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PCT/US2021/064228 Continuation-In-Part WO2022140204A1 (en) 2020-01-08 2021-12-17 Medicament pumps and control systems thereof
PCT/US2022/017368 Continuation-In-Part WO2022178447A1 (en) 2020-01-08 2022-02-22 Medicament pumps with systems and methods for improving user experience

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PCT/US2021/064228 Continuation-In-Part WO2022140204A1 (en) 2020-01-08 2021-12-17 Medicament pumps and control systems thereof
PCT/US2022/017368 Continuation-In-Part WO2022178447A1 (en) 2020-01-08 2022-02-22 Medicament pumps with systems and methods for improving user experience

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4955861A (en) * 1988-04-21 1990-09-11 Therex Corp. Dual access infusion and monitoring system
US20090062767A1 (en) * 2007-08-29 2009-03-05 Medtronic Minimed, Inc. Combined sensor and infusion set using separated sites
US20110160697A1 (en) * 2008-08-28 2011-06-30 Medingo Ltd. Device and method for enhanced subcutaneous insulin absorption
US20150105720A1 (en) * 2013-10-14 2015-04-16 Medtronic Minimed, Inc. Therapeutic Agent Injection Device
US9782536B2 (en) * 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US20210093849A1 (en) * 2019-10-01 2021-04-01 Unomedical A/S Connector

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4955861A (en) * 1988-04-21 1990-09-11 Therex Corp. Dual access infusion and monitoring system
US20090062767A1 (en) * 2007-08-29 2009-03-05 Medtronic Minimed, Inc. Combined sensor and infusion set using separated sites
US20110160697A1 (en) * 2008-08-28 2011-06-30 Medingo Ltd. Device and method for enhanced subcutaneous insulin absorption
US9782536B2 (en) * 2009-01-12 2017-10-10 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US20150105720A1 (en) * 2013-10-14 2015-04-16 Medtronic Minimed, Inc. Therapeutic Agent Injection Device
US20210093849A1 (en) * 2019-10-01 2021-04-01 Unomedical A/S Connector

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