WO2022159052A2 - Unité de dérivation cardiopulmonaire de femme enceinte-fœtus - Google Patents

Unité de dérivation cardiopulmonaire de femme enceinte-fœtus Download PDF

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Publication number
WO2022159052A2
WO2022159052A2 PCT/TR2021/050161 TR2021050161W WO2022159052A2 WO 2022159052 A2 WO2022159052 A2 WO 2022159052A2 TR 2021050161 W TR2021050161 W TR 2021050161W WO 2022159052 A2 WO2022159052 A2 WO 2022159052A2
Authority
WO
WIPO (PCT)
Prior art keywords
pregnant
fetus
blood
attached
reservoir
Prior art date
Application number
PCT/TR2021/050161
Other languages
English (en)
Other versions
WO2022159052A3 (fr
Inventor
Aydaş Serhat
Original Assignee
Serhat Aydas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serhat Aydas filed Critical Serhat Aydas
Publication of WO2022159052A2 publication Critical patent/WO2022159052A2/fr
Publication of WO2022159052A3 publication Critical patent/WO2022159052A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2240/00—Specially adapted for neonatal use

Definitions

  • This invention is related to a pregnant-fetus cardiopulmonary bypass unit which is intended to minimize the possible damages by cooling down the patient (hypothermia), thus cooling down the fetal circulation and the baby and creating a placental vasoconstriction while the device continues pumping blood in pregnant patients who are going under an open heart surgery with a cardiopulmonary bypass (heart lung machine) in the field of cardiology and cardiovascular surgery.
  • the heater inside the bypass unit in this invention the blood at a lowered temperature coming from the mother is heated up and this heated blood is transferred to the vein through which the mother feeds the baby with the fetus arterial cannula. Therefore, the placenta which feeds the baby continuously receives warm blood and the baby is kept from cooling down during the operation and being negatively affected by obstructing the placental vasoconstriction.
  • cardiopulmonary bypass is commonly used in the surgical treatment of heart diseases. With the cardiopulmonary bypass, the heart and lung functions are disabled temporarily and these functions are fulfilled by extracorporeal mechanical systems.
  • the blood starts to flow in between the aorta layers or towards the body cavities.
  • the blood which enters the ruptured or cracked vein progresses here and disrupts the blood flow. This is especially a common disorder in pregnant women as the vein structure weakens and softens. In these situations which require an operation, the function of the heart is temporarily transferred to the heart lung machine.
  • the body temperature is lowered down in pregnant women who undergo an open heart surgery with a cardiopulmonary bypass.
  • the blood pumped with the cardiopulmonary bypass device from the mother whose body temperature has been lowered down disrupts the fetal circulation and cools down the fetus and leads to negative impacts and losses.
  • the England Patent Certificate no GB1485300 in prior art describes a simple, accurate and precise cardiopulmonary bypass system to obtain a venous flow which is fed by a variable rate gravity from a human circulation system, revive the blood and return it to a circulation system at a rate which is mostly equal to the venous flow rate.
  • Figure-1 A perspective view of the pregnant-fetus cardiopulmonary bypass unit in the present invention.
  • Figure-2 A view of the placental hypothermia preventive perfusion unit in the pregnant-fetus cardiopulmonary bypass unit in the present invention.
  • the pregnant-fetus cardiopulmonary bypass unit (1) in the present invention comprises of; - A venous cannula (2) that is attached to the right heart of the patient and that allows for the extracorporeal circulation of the blood without getting into the heart,
  • a pregnant reservoir (3) that is attached to the venous cannula (2) and that allows for the safe administration of various medication while the blood from the mother is being collected and the tissues and organs are being fed by the blood as necessary,
  • a pregnant pump (4) that is attached to the pregnant reservoir (3) and that pumps the blood coming from the pregnant reservoir (3) to maintain the function of the heart during the operation,
  • a pregnant oxygenator (6) that is attached to the pregnant pump (4) on one end and to the patient's aorta or another artery through the pregnant arterial cannula (5) on the other end, and that allows for clearing the patient's high carbon dioxide concentration blood from its carbon dioxide and returning it to the patient with increased oxygen concentration,
  • a placental hypothermia preventive perfusion unit (7) that is attached to the pregnant reservoir (3) on one end and which includes a heater (7.1) that heats up the blood from the pregnant reservoir (3) with the hot water inside, a fetus reservoir (7.2) attached to the heater (7.1) where the warmed up blood is collected, a fetus pump (7.3) attached to the fetus reservoir (7.2), that pumps the heated blood coming from the fetus reservoir (7.2) during the operation, a fetus oxygenator (7.5) that is attached to the fetus pump (7.3) on one end and attached to the internal iliac artery or vein bilaterally through the fetus arterial cannula (7.4) on the other end and allows for clearing the high carbon dioxide concentration blood from its carbon dioxide and returning it to the placenta at an increased oxygen concentration, and thus, prevents the fetus from cooling down by supplying a warmed up blood flow to the placenta.
  • a heater 7.1
  • the fetus inside the mother is kept from cooling down during the operation and being negatively affected by obstructing the placental vasoconstriction.
  • Another use of the pregnant-fetus cardiopulmonary bypass unit (1) in the present invention is as follows;
  • the blood can also be transferred to the heater (7.1) from the pregnant arterial cannula (5) where the cooled down and oxygenated blood is returned to the patient. From here, it goes to the fetus reservoir (7.2) and it can be pumped to the internal iliac artery or vein bilaterally. As the blood will come oxygenated from the mother in this case, it is possible to pump the warmed-up blood to the placenta without the need for a fetus oxygenator (7.5).
  • the blood in the pregnant reservoir (3) is transferred to the heater (7.1).
  • the heater (7.1) can be in a helix structure in a tank filled with hot water.
  • the blood which is warmed up by going through the heater (7.1) is collected here in the fetus reservoir (7.2). Then, it is pumped to the fetus oxygenator (7.5) with the fetus pump (7.3). Finally, the warmed up and oxygenated blood is transferred to the placenta bilaterally through the fetus arterial cannula (7.4).
  • the condition that the dissection creates an occlusion in the iliac artery and causes a failure in feeding the placenta by blooding the placenta in the retrograde form the iliac vein is another problem that will be solved with the present invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne une unité de dérivation cardiopulmonaire de femme enceinte-fœtus (1) destinée à réduire au minimum les dommages éventuels par un refroidissement de la patiente (hypothermie), refroidissant ainsi la circulation fœtale et le bébé et créant une vasoconstriction placentaire pendant que le dispositif continue à pomper du sang chez des patientes enceintes qui font l'objet d'une chirurgie à cœur ouvert avec une dérivation cardiopulmonaire (machine cœur-poumons) dans le domaine de la cardiologie et de la chirurgie cardiovasculaire. Selon la présente invention, grâce à l'élément chauffant (7.1) situé à l'intérieur de l'unité de dérivation (1), le sang à une température abaissée provenant de la mère est chauffé et ce sang chauffé est transféré vers la veine par laquelle la mère nourrit le bébé avec la canule artérielle fœtale (7.4). Par conséquent, le placenta qui alimente le bébé en continu reçoit du sang chaud et le bébé est protégé contre un refroidissement pendant l'opération et contre tout atteinte néfaste par une obstruction de la vasoconstriction placentaire.
PCT/TR2021/050161 2021-01-21 2021-02-19 Unité de dérivation cardiopulmonaire de femme enceinte-fœtus WO2022159052A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021/00939 2021-01-21
TR202100939 2021-01-21

Publications (2)

Publication Number Publication Date
WO2022159052A2 true WO2022159052A2 (fr) 2022-07-28
WO2022159052A3 WO2022159052A3 (fr) 2022-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2021/050161 WO2022159052A2 (fr) 2021-01-21 2021-02-19 Unité de dérivation cardiopulmonaire de femme enceinte-fœtus

Country Status (1)

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WO (1) WO2022159052A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7198751B2 (en) * 2003-01-14 2007-04-03 Medtronic, Inc. Disposable, integrated, extracorporeal blood circuit
SG10201802035VA (en) * 2013-03-15 2018-04-27 Childrens Hospital Philadelphia Extracorporeal life support system and methods of use thereof
US20160106903A1 (en) * 2013-04-29 2016-04-21 Hestiamedtech Ab Fluid Pump Systems, and Related Methods for Pumping Biological Fluids

Also Published As

Publication number Publication date
WO2022159052A3 (fr) 2022-10-06

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