WO2022149619A1

WO2022149619A1 - Covid 19 virus/flu aerosol spray composition and methods for combating, contracting and spreading of viruses and colds

Info

Publication number: WO2022149619A1
Application number: PCT/KE2021/000057
Authority: WO
Inventors: Herman Lee BIGHAM, Jr.
Original assignee: Bigham Herman Lee Jr
Priority date: 2020-12-11
Filing date: 2021-12-21
Publication date: 2022-07-14

Abstract

The covid 19 virus/Flu aerosol spray is a formulation and method of combating the contracting and spread of viruses and colds. It is composed of antibacterial and antiviral natural herbs that allows you to instantly respond to incidents of potential viral exposure by safely cleansing your hands, other surfaces and additionally instantly killing any possible virus exposure through your nose and mouth.

Description

Covid 19 Virus / Flu Aerosol Spray composition and methods of combating, contracting and spread of viruses and colds.

Technical Field

(0001) The present disclosure relates to a Covid 19 Virus / Flu Aerosol Spray formulation and method of combating, contracting and spread of viruses and colds. It is composed of antibacterial and antiviral natural herbs that allows you to instantly respond to incidents of potential viral exposure by safely cleansing your hands, other surfaces and additionally instantly killing any possible virus exposure through your nose and mouth.

Background

(0002) Currently, the world's population and economies are gravely suffering from a series of devastating viruses and Pfizer Inc, one of the chief vaccine makers, on Friday predicted the pandemic would last until 2024.

(0003) The Omicron variant appears to be far more transmissible than previous iterations of the virus, and more agile in evading immune defenses, according to early studies.

(0004) Public health officials say it is likely to become the dominant variant in the country, following fast-moving spreads in countries such as South Africa and the United Kingdom, and could strain hospitals still struggling to contain this summer's Delta variant surge.

(0005) According to the World Health Organization, COVID-19 spreads from an infected person's mouth or nose in small liquid particles referred to as "respiratory droplets" when the person coughs, sneezes, speaks, or breathes i heavily. The nose is the first line of defense for the respiratory system and the initial site of infection of viruses. Viruses invade through the nose & mouth and replicate themselves first in the nasal and oral tissue.

(0006) With that in mind, it makes sense then that oral preventive care using our Corona / Flu Aerosol Spray" will help eliminate virus particle exposure in one's mouth and throat. Our system enhances the immune response and kills the virus before it can become attached to the nasal or oral tissue.

(0007) The Covid 19 Virus - Flu Aerosol formulation responds to the urgent need for protection from the spread of the viruses by the Unvaccinated and anti-Mask movement. They can discreetly use our spray system during and after the encounter to protect themself from contracting and potentially spreading the virus. Also, the large disparity in the vaccine distribution worldwide is allowing new virus strains to be produced.

Brief Summary

(0008) This brief summary is provided to introduce Prior Art concepts and methods in a simplified form that are further described below This exemplary embodiment this is of a anti - Covid 19 Virus aerosol spray.

(0009 The spray is composed of 98% Neem leaf extract from boiling Neem leaves in water and 1 % lemon & eucalyptus extracts extract. Eucalyptus and Lemon oil are natural Antihistamines that relieve sinus congestion, unblock a stuffed nose, and promote sinus drainage and are also natural food preservative.

(0010) Most of the Covid-Flu nasal sprays currently in development include Nasitrol marketed by Amcyte in the US through a licensing agreement with Laboratorio Pablo Cassara. Nasitrol, an algae-derived nasal spray developed by Argentinian company Laboratorio Pablo Cassara, has been approved in Argentina for the prevention of the common cold for a decade. (0011) Similarly American clinical-stage biotech IGM Biosciences has exclusively licensed the rights to the antibodies used to generate IGM-6268 and related intellectual property from the University of Texas S IGM-6268 is an intranasally-administered immunoglobulin M (IgM) antibody treatment candidate for the treatment and prevention of Covid-19. In preclinical studies, IGM-6268 demonstrated significantly greater neutralization of SARS-CoV-2 with an IgM antibody compared to immunoglobulin G antibodies, the potent neutralization of all evaluated mutant variants of concern and variants of interest, and the ability to provide effective preventative and therapeutic protection when delivered intranasally in mice.

(0012) In addition, Carragelose, a nasal spray currently in market in the United Kingdom, is said to block the virus for up to 2 days with multiple sprays per day. Marinomed Biotech's red seaweed derived Carragelose is a broadly active antiviral compound for treating respiratory diseases, approved in the European Union, Australia and parts of Asia in the form of nasal sprays, throat sprays and lozenges. Carragelose coats the mucosal tissues of the respiratory tract, forming a physical barrier that helps to protect against viral infection.

(0013) Canadian biotech firm Sanotize currently has a nitric oxide nasal spray, Enovid, in market in Israel as treatment for Covid. The spray received emergency use authorization in Israel after Phase II trials showed it reduces SARS-CoV-2 viral load, and therefore decrease a person's transmission of the virus. Releasing a small dose of nitric oxide, a natural nano-molecule with anti microbial properties including against SARS-CoV-2, Enovid provides a physical and chemical barrier in the nose.

(0014) Researchers at the University of London are working on the first set of clinical trials for a nasal spray: nitric oxide is its active ingredient, and it's proven to both kill 99.9% of the virus that causes Covid and grant protection against incoming and outgoing viruses. Nitric oxide is something that is found and produced in red blood cells, but it also kills viruses virtually on contact.

(0015) Approved in Israel, Taffix, a spray created by Nasus Pharma, creates a barrier of both mechanical and chemical protection for around five hours when inhaled through the nose.

(0016) Sensory Cloud, a health technology firm, has developed a nasal spray known as FEND. The nasal spray delivers a calcium chloride-based solution, similar to a saline spray, which could prevent viral shedding by up to 99% for as long as six hours. The device will come in a handheld pump, called the Nimbus, which can turn the mineral solution into a fine mist. Like face masks, FEND is more to stop you from exhaling particles than it is to block you from inhaling other people's particles. The spray delivers a chemical reaction which traps infected droplets that might ordinarily get launched into the air (or travel farther into the body) when you cough or sneeze, the way to your lungs, but too small to get trapped in your nostrils.

(0017) Researchers in Utah are studying the effectiveness of antihistamine- treated nasal spray on cell cultures infected with SARS-CoV-2, the virus responsible for COVID-19. Preliminary results from the new in vitro study indicated that chlorpheniramine maleate— an over-the-counter antiinflammatory drug could reduce the presence of infection when combined with a nasal spray solution. Previous research has suggested chlorpheniramine maleate (CPM) acts as an antiviral treatment against various influenza strains as well.

(0018) Researchers are hoping that the nasal spray could be squirted through the nostrils, enter nasal epithelial cells, and hijack their protein-making machinery so that they make Regeneron’s antibodies. Normally, only immune cells create antibodies, which makes the new idea a particularly innovative approach.

(0019) Since the coronavirus enters the lungs through the nasal passage, the spray could halt the infection in its tracks. What’s more, AAVs cause only a mild immune response so the side effects could be less severe than the frontrunner vaccines, which work by training the immune system to recognize a key protein of the virus. Scientists at the University of Pennsylvania and the biotech firm Regeneron are investigating whether technology developed for gene therapy can be used to make a nasal spray that will prevent infection with the new coronavirus.

(0020) The short comings of the prior art include the risk associated with creating and introducing foreign genetically produced anti bodies; chemically produced nasal sprays and mouthwashes that have limited application when it comes to providing comprehensive protection against contracting a spreading virus.

(0021) Conversely, the Corona - Flu Aerosol Spray completely combats the spread of viruses by providing comprehensive protection against contracting a spreading virus through the use of the natural Neem anti-viral formulation which instantly kills any possible virus exposure through your nose, mouth and surface contact.

Detailed Description

(0022) The following detailed description is merely exemplary in nature and is not intended to limit the invention or the application and uses of the invention. As used herein, the word "exemplary" means "serving as an example, instance, or illustration." Thus, any embodiment described herein as "exemplary" is not necessarily to be construed as exemplary or advantageous over other embodiments. All of the embodiments described herein the exemplary embodiments provided to enable persons skilled in the art to make or use the invention and not to limit the scope of the invention which is defined by the claims. Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, brief summary, or the following detailed description

(0023) Neem (Azadirachta Indica) is a safe natural product commonly used as an herbal tea and is being used as the base for this anti - Covid 19 Virus aerosol spray. The spray is composed of 98% Neem leaf extract from boiling Neem leaves in water and 1 % lemon & eucalyptus extracts extract. Eucalyptus and

Lemon oil are natural Antihistamines that relieve sinus congestion, unblock a stuffed nose, and promote sinus drainage and are also natural food preservative.

(0024) The nose is the first line of defense for the respiratory system and the initial site of infection of viruses. Viruses invade through the nose, mouth and replicate themselves first in the nasal & oral tissue. Our system enhances the immune response and kills the virus before it can become attached to the nasal or oral tissue by breaking down the virus shell. (0025) A coronavirus is a common virus from a large family of viruses that can cause illnesses such as the common cold and SARS. Severe acute respiratory syndrome coronavirus (SARS-CoV) is a viral infection caused by a coronavirus that results in a flu-like respiratory illness. One of the most pernicious aspects of the Covid 19 Virus is that it can block your immune system from fully responding to the virus allowing it to be overwhelmed.

(0026) In the case of a virus, Neem is a strong anti-viral with a one-two punch. First, and perhaps most importantly neem boosts your body's immune system, kicking both the lymphocytic and cell-mediated immune systems into overdrive. There are volumes of documentation on studies on the use and eeffectiveness of our natural ingredient as a anti bacterial cleanser and anti viral with demonstrated ability to kill the Corona / Flu and numerous other viruses. Dr. Das Sarma recently published a study in Frontiers in Cellular Neuroscience showing that NBE binds to the Spike protein found in mouse hepatitis virus (MHV), a group 2 coronavirus that serves as a model for neuroinflammatory diseases in humans. In this study, NBE binding to the Spike protein inhibited cell-to-cell fusion and viral replication, effectively reducing neuroinflammation.

(0027) The novel coronavirus (SARS-CoV-2) that causes the respiratory disease COVID-19 (as well as SARS, OC43, and other human coronaviruses) also contains the Spike protein, composed of two subunits known as SI and S2. The spike protein gives SARS-CoV-2 its characteristic jagged shape and mediates viral entry into host cells. The SI subunit first binds to a receptor located on the surface of the host cell, and then the S2 subunit fuses the viral and host cell membranes. This way, genetic material from the novel coronavirus enters the host cell and uses the cellular machinery to replicate the virus and spread to other host cells.

(0028) However, if another compound binds to the coronavirus Spike protein, the virus is unable to bind to a host cell. Similar to its antiviral activity against MHV, NBE may reduce viral entry and spread of SARS-CoV-2 by targeting the cell walls of the virus.

(0029) A report published in the Journal of Communicable Diseases indicates that neem leaf extract inactivated; interfered with the reproduction of the coxsackie B virus in test tubes and inhibited plaque formation (attachment) in six types of the Coxsackie virus and interfered with the virus's reproductive cycle at an early stage. One of a group of enteroviruses that are second only to the "common cold" as the most infectious viral agents in humans, the enteroviruses cause an estimated 10 to 15 million infections annually. By spraying and your nose and mouth you pretreat the target cells most likely to become infected, significantly blocking the virus from entering your system. Researchers tested the ability of Neem to block different and more virulent strains of the virus and found that the bark extract blocked entrance even on the more virulent strains.

(0030) Our formulation compared favorably with the synthetic compounds works against all strains of influenza rather than specific variations impacted by the synthetic drug. Controlling any virus typically requires very specific vaccines that may work on just one or two strains. Influenza (commonly known as the flu) continues to be a threatening disease due to the number of deaths and hospitalizations it causes every year. According to new estimates by the US Centre for Disease Control and Prevention (CDC), between 291,000 and 646,000 people worldwide die from seasonal influenza-related respiratory illnesses each year.

(0031) In one recent study, published in the peer-reviewed BMC Complementary Medicine and Therapy, researchers looked at three compounds in neem (nimbalflavone, rutin and hyperoside) against an influenza virus nucleoprotein, and then compared their action against six other drugs known to inhibit the growth of viruses. Hyperoside from neem leaf extract compared favorably with the synthetic compounds. More importantly, hyperoside worked against all strains of influenza rather than specific variations impacted by the synthetic drug.

(0032) The Covid 19 Virus - Flu Aerosol Spray will be dispensed from a 60 ml soft plastic bottle with a nasal aerosol spray top bottle. The personal spray will be in a 60 ml bottle secured by the tamperproof seal with a nasal spray top and contain a month's supply for two series of applications a day.

(0033) The Large group spray will be in a 60 ml bottle secured by the tamperproof seal with a nasal spray top and contain an amount sufficient to administer our full system of protection for up to (100) persons entering a building or event. A disposable straw will be used to isolate spray nozzle to maintain sanitary conditions when spraying gest noses and mouths before entry into gatherings.

(0034) Recommended uses: Gently blow your nose to clear both nostrils and discard tissue. Spray once in nose; mouth and on hands before leaving home and after lunch or as needed based on incidence of potential exposure. The protective spray will last aprox. six hours. The Covid 19 Virus - Flu Aerosol Spray can be used at any point during the day you may be exposed to airborne, or surface virus contaminates. When you feel at risk, just take out The Covid 19 Virus - Flu Aerosol Spray and spray into your nose and throat and swish around for 30 seconds and swallow to kill any germs and viruses present on contact. Then spraying your hands, mask and any other questionable surfaces to provide complete protection. Tosheka Corona / Flu Aerosol Spray" may be used by anyone who is concerned about virus transmission, particularly those who are at high risk. We especially recommended this product for those who work or engage in close-contact activities like schools, hotels, restaurants, travel, healthcare workers, caregiving, etc. where social distancing is difficult.

Claims

CLAMS What is Clamed:

1. A composition comprising 98% of Neem extract of azadirachta indica by volume of one liter and used in Anti-Virus - Flu Aerosol formulation that provides a natural, alternative, comprehensive protection from contracting and spread of viruses and colds.

2. A composition comprising according to claim 1 , wherein further comprises 1% by volume of eucalyptus oil. Eucalyptus oil a natural Antihistamines that relieve sinus congestion, unblock a stuffed nose, and promote sinus drainage and are also natural food preservative.

3. A composition comprising according to claim 1, wherein further comprises 1% by volume of lemon oil. Lemon oil a natural Antihistamines that relieve sinus congestion, unblock a stuffed nose, and promote sinus drainage and are also natural food preservative.

4. A composition comprising according to claim 1 comprising 98% of Neem extract of azadirachta indica by volume of one liter and 1% by volume of lemon and Eucalyptus oil a natural Antihistamines that relieve sinus congestion, unblock a stuffed nose, and promote sinus drainage and are also natural food preservative and are collectively used in Anti- Virus - Flu Aerosol formulation that provides a natural, alternative, comprehensive protection from contracting and spread of viruses and colds.

5. A composition comprised according to claim 1 of the Covid 19 Virus - Flu Aerosol formulation that provides a natural, alternative, comprehensive protection from contracting and spread of viruses and colds.

6. A composition comprised according to claim 1 of the Covid 19 Virus - Flu Aerosol formulation that is an all-natural safe formulation that eliminates the short comings of the prior art include the risk associated with creating and introducing foreign genetically produced anti bodies; chemically produced nasal sprays and mouthwashes that have limited application when it comes to providing comprehensive protection against contracting a spreading virus.

7. A composition comprised according to claim 1 of the Covid 19 Virus - Flu Aerosol formulation that compared favorably with the synthetic compound’s effectiveness against all strains of influenza rather than specific variations impacted by the synthetic drug as in other products.

8. A composition comprised according to claim 1 of the Covid 19 Virus - Flu Aerosol formulation that can be used as a prophylactic to allow large groups to be able to safely meet providing dual protection from both A - or Pre symptomatic individuals by reducing their virial spread and providing protection from any remaining virial exposure.

9. A composition comprised according to claim 1 of the Covid 19 Virus - Flu Aerosol formulation that responds to the urgent need for protection from the Unvaccinated and anti-Mask movement.