WO2022148500A3 - Use of polypyrimidine-tract-binding protein in preparation of medication repairing spinal cord injuries - Google Patents

Use of polypyrimidine-tract-binding protein in preparation of medication repairing spinal cord injuries Download PDF

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Publication number
WO2022148500A3
WO2022148500A3 PCT/CN2022/084398 CN2022084398W WO2022148500A3 WO 2022148500 A3 WO2022148500 A3 WO 2022148500A3 CN 2022084398 W CN2022084398 W CN 2022084398W WO 2022148500 A3 WO2022148500 A3 WO 2022148500A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypyrimidine
medication
tract
preparation
binding protein
Prior art date
Application number
PCT/CN2022/084398
Other languages
French (fr)
Chinese (zh)
Other versions
WO2022148500A2 (en
Inventor
杨日云
潘静莹
包璟崟
夏盼慧
Original Assignee
南通大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南通大学 filed Critical 南通大学
Publication of WO2022148500A2 publication Critical patent/WO2022148500A2/en
Publication of WO2022148500A3 publication Critical patent/WO2022148500A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

A use of a polypyrimidine-tract-binding protein silencer combined with retinoic acid and purmorphamine in the preparation of a medication for repairing spinal cord injuries.
PCT/CN2022/084398 2021-04-16 2022-03-31 Use of polypyrimidine-tract-binding protein in preparation of medication repairing spinal cord injuries WO2022148500A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110413331.8A CN113171369A (en) 2021-04-16 2021-04-16 Application of polypyrimidine sequence binding protein in preparation of spinal cord injury repair drug
CN202110413331.8 2021-04-16

Publications (2)

Publication Number Publication Date
WO2022148500A2 WO2022148500A2 (en) 2022-07-14
WO2022148500A3 true WO2022148500A3 (en) 2022-08-25

Family

ID=76923511

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/084398 WO2022148500A2 (en) 2021-04-16 2022-03-31 Use of polypyrimidine-tract-binding protein in preparation of medication repairing spinal cord injuries

Country Status (2)

Country Link
CN (1) CN113171369A (en)
WO (1) WO2022148500A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113171369A (en) * 2021-04-16 2021-07-27 南通大学 Application of polypyrimidine sequence binding protein in preparation of spinal cord injury repair drug

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104313025A (en) * 2014-08-29 2015-01-28 南通大学 siRNA capable of inhibiting forming of glial scar after central nervous system injury, recombinant vector and application thereof
CN112312928A (en) * 2018-04-11 2021-02-02 加利福尼亚大学董事会 Reprogramming of non-neuronal cells to neurons, and methods and compositions for treating neurodegenerative diseases and disorders
CN113171369A (en) * 2021-04-16 2021-07-27 南通大学 Application of polypyrimidine sequence binding protein in preparation of spinal cord injury repair drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102899285A (en) * 2011-07-29 2013-01-30 复旦大学 Method for differentiation of embryonic stem cells into nerve cells through in vitro induction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104313025A (en) * 2014-08-29 2015-01-28 南通大学 siRNA capable of inhibiting forming of glial scar after central nervous system injury, recombinant vector and application thereof
CN112312928A (en) * 2018-04-11 2021-02-02 加利福尼亚大学董事会 Reprogramming of non-neuronal cells to neurons, and methods and compositions for treating neurodegenerative diseases and disorders
CN113171369A (en) * 2021-04-16 2021-07-27 南通大学 Application of polypyrimidine sequence binding protein in preparation of spinal cord injury repair drug

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LIU XUEYUAN, LI DEHUA, SHAN WEI JIANG, DONG: "Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Motoneurons Induced by Retinoic Acid Combined with Purmorphamine", CHINESE JOURNAL OF NEUROANATOMY, vol. 27, no. 6, 30 September 2011 (2011-09-30), pages 647 - 652, XP055961183 *
QIN, HUA: "Small Molecules Induce Direct Conversion of Somatic Cells into Motor Neurons", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES-TIANJIN MEDICAL UNIVERSITY, 1 January 2018 (2018-01-01), XP055772815, Retrieved from the Internet <URL:https://tra.oversea.cnki.net/KCMS/detail/detail.aspx?dbname=CDFDLAST2019&filename=1018883613.nh> [retrieved on 20210205] *
ZHANG, YANAN: "Research Advances in Methods for Reprogramming Somatic Cells into Motor Neurons", SHANDONG YIYAO - SHANDONG MEDICAL JOURNAL, SHANDONG SHENG WEISHENGTING,, CN, vol. 60, no. 9, 31 December 2020 (2020-12-31), CN , XP055961184, ISSN: 1002-266X *

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Publication number Publication date
CN113171369A (en) 2021-07-27
WO2022148500A2 (en) 2022-07-14

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