WO2022143306A1

WO2022143306A1 - Aneurysm occlusion apparatus and microcatheter thereof

Info

Publication number: WO2022143306A1
Application number: PCT/CN2021/140116
Authority: WO
Inventors: 程舒宇; 王永胜
Original assignee: 杭州德诺脑神经医疗科技有限公司
Priority date: 2020-12-31
Filing date: 2021-12-21
Publication date: 2022-07-07
Also published as: CN112656477B; CN112656477A

Abstract

A microcatheter (100) of an aneurysm occlusion apparatus, comprising a occlusion portion (110) and an operation portion (120). After the occlusion portion (110) extends into an aneurysm (900), the middle portion of the occlusion portion (110) can expand outward in the radial direction to be spread; the operation portion (120) is detachably connected to the occlusion portion (110); and after the operation portion (120) is separated from the occlusion portion (110), the operation portion (120) can retain the occlusion portion (110) at the neck of the aneurysm (900). The tubular structure of the occlusion portion (110) can fill the aneurysm (900) with a plugging material (800) by means of the occlusion portion (110), and can maintain the spread state of the occlusion portion (110) so as to seal the neck of the aneurysm (900) more effectively, thereby avoiding dissolution of the formed thrombus under the impact of the blood flow, and improving the treatment effect.

Description

Aneurysm occlusion device and its microcatheter

technical field

The invention relates to the technical field of aneurysm treatment, in particular to an aneurysm occlusion device and a microcatheter thereof.

Background technique

Aneurysm is a common vascular disease that is the result of dilation or bulging of the arterial wall due to lesions or damage to the arterial wall.

In treating aneurysms by endovascular implants, the goal is to exclude the internal volume of the aneurysm sac from the influence of arterial blood pressure and blood flow. As long as the inner wall of the aneurysm experiences blood pressure and/or blood flow, the aneurysm is at risk of rupture.

Non-surgical treatments include vascular occlusion devices, which typically have multiple embolic coils that are delivered to the vasculature using a catheter delivery system. In the currently preferred procedure for the treatment of an intracranial aneurysm, a delivery catheter with an embolic coil is typically first inserted into the non-cranial vasculature through the femoral artery in the hip or inguinal region and directed to a predetermined delivery site in the intracranial blood vessel point. The aneurysm sac is then filled with embolic material to form a thrombotic material, thereby protecting the wall from blood pressure and blood flow. The thrombotic material then substantially returns to the original vessel shape along the plane of the neck of the aneurysm, which is the imaginary surface where the intima of the vessel would be if the aneurysm were not forming. However, simply utilizing an embolic coil is not always effective in treating aneurysms because recanalization of the aneurysm and/or coil compaction can occur over time, leading to recanalization of the aneurysm and the formation of new blood flow path.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a microcatheter, which can seal the aneurysm more effectively and improve the treatment effect.

In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

According to one aspect of the present invention, the present invention provides a microcatheter, comprising an occlusion part and an operation part; the occlusion part is a tubular structure, and the middle part of the occlusion part can be expanded radially outward to expand; the distal end of the operation part is detachable The connection is at the proximal end of the occlusion part for disengaging the occlusion part when the occlusion part is deployed.

In some embodiments, the occlusion portion includes a distal tube, a proximal tube and a mesh braid; two ends of the mesh braid are respectively connected to the distal tube and the proximal tube; the The mesh braid can be expanded radially under the extrusion of the distal tube and the proximal tube; the proximal end of the proximal tube is detachably connected to the operating portion.

In some embodiments, a ring is connected between the distal end of the operating portion and the proximal end of the proximal tube, and the ring is made of a polymer electrolyte material.

According to one aspect of the present invention, the present invention provides an aneurysm occlusion device, comprising a microcatheter and an inner liner; the microcatheter includes an occlusion part and an operation part; the occlusion part is a tubular structure, and the middle part of the occlusion part can be along the Expanding radially outward; the distal end of the operating portion is detachably connected to the proximal end of the occlusive portion, so as to be used to disengage the occlusive portion when the occlusive portion is deployed; the inner liner tube is slidably Passing through the occlusion part; the distal end of the inner lining tube can move from the distal end of the occlusion part to the proximal end of the occlusion part in the axial direction, and be drawn out from the proximal end of the occlusion part.

In some embodiments, the aneurysm occlusion device further includes a driving member, which can be fixed or abutted on the distal tube to drive the distal tube to move toward the proximal tube; the The driver can be separated from the occlusion portion to move from the distal end of the occlusion portion to the proximal end of the occlusion portion and withdraw from the proximal end of the occlusion portion.

In some embodiments, the outer peripheral wall of the distal end of the inner lining tube is protruded with a snap protrusion to form the driving member, and the snap protrusion can abut with the distal end of the distal tube; the microcatheter A guide groove penetrating in the axial direction is correspondingly provided on the inner peripheral wall of the operation part, the distal end tube and the proximal end tube; the snap protrusion can slide in the guide groove.

In some embodiments, a step is formed on the inner side of the distal end of the distal tube, and the snap protrusion can overlap on the step, so that the snap protrusion can drive the proximal tube toward the distal end Tube close.

In some embodiments, the inner liner tube includes a main body portion at the proximal end and a fitting portion at the distal end, the radial dimension of the fitting portion is larger than the radial dimension of the main body portion, and the outer peripheral wall of the fitting portion is on the outer peripheral wall of the fitting portion. A guide groove which penetrates in the axial direction is provided; the inner peripheral wall of the distal end tube is protruded with a locking protrusion to form the driving member, and the locking protrusion can slide in the guide groove.

In some embodiments, the inner circumference of the distal tube is provided with an axially penetrating helical groove; the outer peripheral wall of the distal end of the inner lining tube is protruded with helical teeth to form the driving member, and the helical teeth are formed. capable of sliding within the helical groove; the proximal tube and the inner circumference of the operating portion extend radially outward beyond the helical teeth, so that the helical teeth can follow the liner tube from the operating portion proximal extraction.

In some embodiments, the outer peripheral wall of the distal end of the inner lining tube is provided with a spiral groove, and the spiral groove extends to the end surface of the distal end of the inner lining tube; the inner peripheral wall of the distal end tube is protruded with a spiral groove The helical teeth are formed to form the driving member; the helical teeth can slide in the helical grooves.

In some embodiments, the helical teeth are threaded teeth, the distal tube is provided with a threaded hole, and the helical groove is formed on the inner peripheral wall of the distal tube.

In some embodiments, the driving member is a wire, the wire is connected to the distal tube, the wire passes through the proximal tube and the operating portion and passes through the proximal end of the operating portion out.

In some embodiments, the microcatheter is provided with a guide hole axially penetrating the proximal tube and the operating portion, and the drawing wire is passed through the guide hole.

In some embodiments, there are at least two drawing wires, and the axes of the at least two drawing wires are in the same plane as the axis of the distal tube.

In some embodiments, the proximal end of the distal tube is provided with a groove, and the drawing wire is fixed in the groove.

In some embodiments, the drawing wire is a nickel-titanium wire, the distal end of which can be fused and separated from the distal tube after being energized.

In some embodiments, the driving member is an elastic piece, and the elastic piece is fixed at the distal end of the inner lining tube; the elastic piece extends radially outward beyond the inner diameter of the distal tube; the elastic piece can elastically shrink inside the distal tube, the proximal tube and the operating portion, so as to be able to be withdrawn from the proximal end of the operating portion along with the inner lining tube.

In some embodiments, the operating portion is a tubular structure in which an internal tube hole communicates with an internal tube hole at the proximal end of the blocking portion; the lining tube is slidably penetrated through the blocking portion and the operating portion .

As can be seen from the above technical solutions, the present invention at least has the following advantages and positive effects:

In the present invention, after the occlusion part extends into the aneurysm, the middle part of the occlusion part can be expanded radially outward to block the neck of the aneurysm; the operation part and the occlusion part are detachably connected, so that the operation part and the occlusion part are detachably connected. After the part is separated, the operation part can keep the occlusion part at the neck of the aneurysm. The tubular structure of the occlusion part can fill the aneurysm with a plunger through the occlusion part to fill the aneurysm; and can fill the occlusion part with a plunger, maintain the expanded state of the occlusion part, and use the plunger in the occlusion part to The neck of the aneurysm is more effectively sealed to prevent or reduce the flow of blood from the aneurysm, so that an effective thrombus can be quickly formed inside the sealed aneurysm, so as to prevent the formed thrombus from being dissolved under the impact of blood flow, and improve the therapeutic effect .

Description of drawings

FIG. 1 is a schematic structural diagram of the first embodiment of the aneurysm occlusion device of the present invention.

FIG. 2 is a schematic structural diagram of the first embodiment of the aneurysm occlusion device of the present invention in a deployed state.

FIG. 3 is a schematic cross-sectional structural diagram of the microcatheter of the aneurysm occlusion device shown in FIG. 1 .

FIG. 4 is a top view of the microcatheter of the aneurysm occlusion device of FIG. 1 .

FIG. 5 is a schematic cross-sectional structural diagram of the inner liner tube of the aneurysm occlusion device shown in FIG. 1 .

FIG. 6 is a schematic diagram of the release state of the clamping protrusion and the distal tube in the aneurysm occlusion device shown in FIG. 1 .

FIG. 7 is a schematic diagram of the locking state of the snap protrusion and the distal tube in the aneurysm occlusion device shown in FIG. 1 .

FIG. 8 is a schematic view of the aneurysm occlusion device of FIG. 1 where the guide wire reaches the aneurysm of the lateral wall of the artery.

FIG. 9 is a schematic view of the microcatheter reaching the aneurysm of the arterial side wall in the aneurysm occlusion device of FIG. 1 , wherein the occlusion portion is not deployed.

FIG. 10 is a schematic view of the microcatheter reaching the aneurysm of the arterial side wall in the aneurysm occlusion device of FIG. 1 , wherein the occlusion part is in a deployed state.

FIG. 11 is a schematic view of the structure of the aneurysm occlusion device shown in FIG. 1 when a plunger is filled into the aneurysm of the lateral wall of the artery.

Fig. 12 is a schematic view of the aneurysm occlusion device shown in Fig. 1 after the occlusion portion is implanted into an arterial sidewall aneurysm.

FIG. 13 is a schematic view of the aneurysm occlusion device of FIG. 1 where the guidewire reaches the non-lateral arterial aneurysm.

Fig. 14 is a schematic diagram of the microcatheter reaching the non-lateral arterial aneurysm in the aneurysm occlusion device of Fig. 1, wherein the occlusion portion is not deployed.

Fig. 15 is a schematic view of the microcatheter reaching the non-lateral arterial aneurysm in the aneurysm occlusion device of Fig. 1, wherein the occlusion portion is in a deployed state.

Fig. 16 is a schematic view of the structure of the aneurysm occlusion device of Fig. 1 when a plunger is filled into a non-lateral arterial aneurysm.

Fig. 17 is a schematic view of the aneurysm occlusion device of Fig. 1 after the occlusion portion is implanted into a non-lateral arterial aneurysm.

FIG. 18 is a schematic structural diagram of the second embodiment of the aneurysm occlusion device of the present invention.

FIG. 19 is a schematic structural diagram of the second embodiment of the aneurysm occlusion device of the present invention in a deployed state.

FIG. 20 is a schematic cross-sectional view of the microcatheter of the aneurysm occlusion device shown in FIG. 18 .

FIG. 21 is an enlarged view of A in FIG. 20 .

FIG. 22 is a schematic cross-sectional structural diagram of the inner liner tube of the aneurysm occlusion device shown in FIG. 18 .

FIG. 23 is a schematic view of the aneurysm occlusion device of FIG. 18 where the guide wire reaches the aneurysm of the lateral wall of the artery.

Fig. 24 is a schematic view of the microcatheter reaching the aneurysm of the side wall of the artery in the aneurysm occlusion device of Fig. 18, wherein the occlusion portion is not deployed.

Fig. 25 is a schematic view of the microcatheter reaching the aneurysm of the arterial side wall in the aneurysm occlusion device of Fig. 18, wherein the occlusion portion is in a deployed state.

FIG. 26 is a schematic view of the structure of the aneurysm occlusion device of FIG. 18 when a plunger is filled into an arterial sidewall aneurysm.

FIG. 27 is a schematic view of the aneurysm occlusion device of FIG. 18 after the occlusion portion is implanted into the aneurysm of the side wall of the artery.

FIG. 28 is a schematic view of the aneurysm occlusion device of FIG. 18 where a guidewire reaches a non-lateral arterial aneurysm.

Fig. 29 is a schematic view of the microcatheter reaching the non-lateral arterial aneurysm in the aneurysm occlusion device of Fig. 18, wherein the occlusion portion is not deployed.

Fig. 30 is a schematic view of the microcatheter reaching the non-lateral arterial aneurysm of the aneurysm occlusion device of Fig. 18, wherein the occlusion portion is in a deployed state.

Fig. 31 is a schematic view of the structure of the aneurysm occlusion device of Fig. 18 when a plunger is filled into a non-lateral arterial aneurysm.

FIG. 32 is a schematic view of the aneurysm occlusion device of FIG. 18 after the occlusion portion is implanted into a non-lateral arterial aneurysm.

Fig. 33 is a schematic structural diagram of the third embodiment of the aneurysm occlusion device of the present invention, wherein the support catheter and the guide wire are not shown.

FIG. 34 is a schematic structural diagram of the aneurysm occlusion device of FIG. 33 in a deployed state.

Fig. 35 is a schematic structural diagram of the fourth embodiment of the aneurysm occlusion device of the present invention, wherein the support catheter and the guide wire are not shown.

The reference numerals are explained as follows:

100, microcatheter; 110, occlusion part; 111, distal tube; 112, proximal tube; 113, mesh braid; 114, groove; 115, step; 120, operation part; 130, guide groove; 140, Guide hole; 150, helical groove; 200, lined pipe; 210, clip; 220, spiral tooth; 300, support catheter; 400, guide wire; 500, ring; 600, wire drawing; 700, shrapnel; 800, column plug; 900, aneurysm.

Detailed ways

Exemplary embodiments embodying the features and advantages of the present invention will be described in detail in the following description. It should be understood that the present invention can have various changes in different embodiments without departing from the scope of the present invention, and the descriptions and drawings therein are essentially used for illustration rather than limitation this invention.

In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", " rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc., or The positional relationship is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as a limitation on this application. In addition, the terms "first" and "second" are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, features defined as "first", "second" may expressly or implicitly include one or more of said features. In the description of the present application, "plurality" means two or more, unless otherwise expressly and specifically defined.

For ease of description and understanding, "proximal end" as defined herein refers to the end close to the operator, and "distal end" refers to the end away from the operator.

The following will specifically introduce several embodiments of the aneurysm occlusion device.

1 to 17 are the first embodiment of the present invention:

Referring to FIGS. 1 and 2 , the present embodiment provides an aneurysm occlusion device, which extends into the aneurysm 900 and fills the aneurysm 900 with a plunger 800 to prevent or reduce blood flow in the aneurysm 900 . The aneurysm occlusion device includes a microcatheter 100 , a liner tube 200 slidably inserted through the microcatheter 100 , a support catheter 300 sleeved on the periphery of the microcatheter 100 , and a guide wire 400 through the inner liner tube 200 .

The support catheter 300 is used to support the microcatheter 100, and the support catheter 300 moves the microcatheter 100, the liner tube 200 and the guide wire 400 to the femoral artery in the patient's hip or groin for insertion into the non-intracranial vasculature. Then the guide wire 400 is guided. When the guide wire 400 is guided, the guide wire 400 is moved so that the guide wire 400 reaches the lateral wall of the artery or the lesion of the non-lateral arterial aneurysm 900 to establish an intervention channel, and the microcatheter 100 and the lining tube 200 are moved along the guide wire 400 , and guide the microcatheter 100 and the lining tube 200 to the lesion of the aneurysm 900 of the arterial side wall, and then fill the aneurysm 900 with the plunger 800 through the lining tube 200 .

In this embodiment, the support catheter 300 is a polymer catheter, the support catheter 300 has a certain flexibility, and the inner diameter of the support catheter 300 is slightly larger than the outer diameter of the microcatheter 100, so that the microcatheter 100 can be penetrated in the support catheter 300, so that the microcatheter can be inserted into the support catheter 300. The catheter 100 can slide relative to the support catheter 300 .

The guide wire 400 is a nickel-titanium wire, which has a certain flexibility and can maintain a deformed state, so that the guide wire 400 can be deformed according to the shape of the vessel and protrude into the aneurysm 900 .

In some embodiments, the aneurysm occlusion device does not include the guide wire 400 and the support catheter 300 , the microcatheter 100 does not need to be guided and supported, and the distal end of the microcatheter 100 extends directly into the aneurysm 900 .

In this embodiment, the plunger 800 may be a spring coil and a liquid plunger. When the plunger 800 is a liquid plunger 800, the liquid plunger may be an adhesive agent, such as medical grade silicone adhesive and photocurable adhesive. Alternatively, n-butyl cyanoacrylate (NBCA), polymethyl methacrylate, methyl methacrylate (PMMA996), N-methyl-2-pyrrolidone (NMP), carbonic anhydrase-associated protein 10 (CA10), EA/MMA and DME.

Referring to FIG. 1 to FIG. 3 , in this embodiment, the microcatheter 100 includes an obstructing part 110 and an operating part 120 detachably connected to the proximal end of the obstructing part 110 . The front end of the occlusion part 110 extends into the aneurysm 900 , the inner liner tube 200 is inserted into the occlusion part 110 , and the distal end of the occlusion part 110 is filled with a plunger 800 into the aneurysm 900 .

The occlusion portion 110 is a tubular structure, and the middle portion of the occlusion portion 110 can be expanded radially outward to be expanded, and the occlusion portion 110 is expanded to block the neck of the aneurysm 900 .

In this embodiment, the blocking part 110 includes a distal tube 111 , a proximal tube 112 and a mesh braid 113 . The two axial ends of the mesh braid 113 are respectively connected to the distal tube 111 and the proximal tube 112; the mesh braid 113 can be expanded and expanded in the radial direction under the extrusion of the distal tube 111 and the proximal tube 112. .

The mesh braid 113 is formed by winding or weaving a plurality of nickel-titanium wires through mechanical hinges. In this embodiment, the mesh braid 113 is formed by winding no less than 36 round or flat nickel-titanium wires.

In this embodiment, the operation part 120 is a tubular structure, the operation part 120 is a tubular structure in which the inner tube hole communicates with the inner tube hole at the proximal end of the occlusion part 110 , and the distal end of the operation part 120 is connected to the proximal end of the proximal tube 112 .

In some embodiments, the operating portion 120 may be other structures, such as a rod-shaped structure, the distal end of the operating portion 120 is connected to the proximal tube 112 , and the proximal end of the proximal tube 112 is open. The operation portion 120 is connected to the proximal end of the proximal tube 112 or the outer peripheral side of the proximal tube 112 .

The proximal end of the operation part 120 protrudes from the proximal end of the support catheter 300 , so that the proximal end of the microcatheter 100 protrudes from the proximal end of the support catheter 300 , so that the operator can clamp or support the entire microcatheter 110 at the proximal end of the operation part 120 .

Referring again to FIG. 3 , in this embodiment, the aneurysm occlusion device further includes a ring 500 , and the ring 500 is made of a polymer electrolyte material so that it can be decomposed by electricity. The ring 500 is connected between the distal end of the operating portion 120 and the proximal end of the proximal tube 112 to connect the operating portion 120 and the proximal tube 112 so that the operating portion 120 is detachably connected to the proximal end of the proximal tube 112 .

In this embodiment, the two ends of the ring 500 are respectively connected to the distal end of the operating portion 120 and the proximal end of the proximal end tube 112 through glue.

In some embodiments, the ring 500 connects the distal end of the operating portion 120 and the proximal end of the proximal tube 112 by means of snapping or the like.

In other embodiments, the ring 500 is not disposed between the distal end of the operating portion 120 and the proximal end of the proximal tube 112 , the distal end of the operating portion 120 and the proximal end of the proximal tube 112 are mechanically released, and able to separate. For example, a snap groove is provided on the inner circumference of the distal end of the operating portion 120, the operating portion 120 can be opened radially outward, and split to form two semi-circular structures, and the proximal end of the proximal tube is provided with radially extending The outwardly protruding limiting protrusion is limited in the slot, and the operating portion 120 is radially split into two symmetrical semi-circular annular structures, so that the operating portion 120 and the proximal tube 112 are separated. In addition, in addition to the mechanical release methods exemplified above, the mechanical release methods can also be adopted such as those in Chinese Patent Application Publication No. CN110063765A-Aneurysm Device and Delivery System, and Chinese Patent Application Publication No. CN110896111A-Improved Aneurysm Device The scheme described above, but not limited to this.

Referring to FIGS. 3 and 4 , the microcatheter 100 is provided with a guide groove 130 in the axial direction, and the guide groove 130 penetrates through the inner peripheral walls of the operation portion 120 , the distal tube 111 and the proximal tube 112 .

In this embodiment, a step 115 is also formed on the inner side of the distal end of the distal end tube 111 .

Referring to FIGS. 1 to 5 , the liner tube 200 is a tubular structure, the liner tube 200 is slidably penetrated in the occlusion portion 110 , and the distal end of the liner tube 200 can move axially from the distal end of the occlusion portion 110 to the The proximal end of the blocking part 110 is drawn out from the proximal end of the blocking part 110 and separated from the blocking part 110 .

In this embodiment, the operation portion 120 is a tubular structure with an inner tube hole communicating with the inner tube hole of the proximal tube 112 , and the lining tube 200 is slidably penetrated through the distal tube 111 , the proximal tube 112 , and the mesh braided body. 113 and the operation part 120 so as to be able to be pulled out from the proximal end of the operation part 120 and separated from the microcatheter 100 .

In some embodiments, the liner tube 200 is slidably connected within the occlusion portion 110 and the manipulation portion 120 , and the liner tube 200 can be withdrawn from the proximal end of the occlusion portion 110 . The liner tube 200 does not need to be withdrawn from the proximal end of the operation part 120 , but is separated from the occlusion part 110 together with the operation part 120 .

In this embodiment, the proximal end of the inner lining tube 200 protrudes from the proximal end of the operating portion 120 , so that the proximal end of the inner lining tube 200 can control the sliding of the inner lining tube 200 in the microcatheter 100 .

In this embodiment, the outer peripheral wall of the distal end of the inner lining tube 200 is protruded with a locking protrusion 210 to form a driving member. The locking protrusion 210 abuts on the distal tube 111 for driving the distal tube 111 toward the proximal tube 112 Move to compress the mesh braided body 113 to expand radially;

Referring to FIGS. 5 to 7 , the proximal end of the inner liner tube 200 controls the inner liner tube 200 to slide inside the microcatheter 100 , so that the snap protrusions 210 can abut against the distal end of the distal end tube 111 . When the snap protrusion 210 moves toward its proximal end relative to the microcatheter 100 , the snap protrusion 210 drives the distal tube 111 to move toward the proximal tube 112 and compresses the mesh braid 113 so that the mesh braid 113 radially outwards Expand and expand.

A plurality of the locking protrusions 210 are provided at intervals along the outer peripheral wall of the lining pipe 200 , and there are a plurality of guiding grooves 130 corresponding to the locking protrusions 210 one-to-one. In this embodiment, two snap protrusions 210 are symmetrically arranged on the outer peripheral wall of the liner tube 200 , and the two snap protrusions 210 are symmetrically distributed with respect to the axis of the liner pipe 200 , so that the pressure of the snap protrusions 210 on the distal tube 111 Balanced, the deformation of the mesh knitted body 113 is smooth and uniform.

In this embodiment, a guide groove 130 is correspondingly formed on the ring 500 . In some embodiments, the inner diameter of the ring 500 is larger than the inner diameter of the operating portion 120 and the inner diameter of the proximal tube 112 , and the inner diameter of the ring 500 is radially The ring 500 does not need to be provided with a guide groove 130 beyond the locking protrusion 210 outward.

In this embodiment, the distal end of the inner lining tube 200 protrudes from the distal end of the distal tube 111 , and the snap protrusion 210 overlaps the step 115 of the distal tube 111 , so that the snap protrusion 210 is limited to the step 115 , so that the Effectively avoid the radial deviation of the clamping protrusion 210 relative to the distal tube 111, and ensure the balance of the pressure of the clamping protrusion 210 on the distal tube 111, thereby ensuring a stable pressure on the mesh braid 113, and making the mesh braid 113 stable. Deformation is smooth.

After the clasp 210 drives the mesh braid 113 to deform, the plunger 800 is filled into the aneurysm 900 through the distal end of the lining tube 200 . Correspondingly, the inner liner 200 is pulled to move toward the proximal end of the inner liner 200 relative to the microcatheter 100 , so that the snap protrusions 210 on the inner liner 200 slide in the guide groove 130 , so that the inner liner 200 can move along the occlusion portion 110 The axial direction moves from the distal end of the occlusion part 110 to the proximal end of the inner liner tube 200 , so that the distal end of the inner liner tube 200 can be retracted into the occlusion part 110 and can be withdrawn from the proximal end of the operation part 120 . Among them, the plunger 800 filled in the aneurysm 900 can maintain the expanded state of the mesh braid 113 .

In some embodiments, the inner lining tube 200 includes a main body part at the proximal end and a fitting part at the distal end, the radial dimension of the fitting part is larger than the radial dimension of the main body part, and the outer peripheral wall of the fitting part is provided with an axially passing through part. The guide groove 130 and the locking protrusion 210 are arranged on the inner peripheral wall of the distal tube 111 .

Corresponding guide grooves 130 do not need to be provided in the proximal tube 112 and the operation part 120 , and the inner diameters of the distal tube 111 , the proximal tube 112 and the operation part 120 are larger than the outer diameters of the mating parts of the lining tube 200 . The guide grooves 130 on the inner liner tube 200 and the snap protrusions 210 on the inner peripheral wall of the distal tube 111 are dislocated, and the inner liner tube 200 drives the distal tube to approach the proximal tube 112 , so that the mesh braid 113 unfolds. After the mesh braid is unfolded, the inner liner tube 200 is rotated so that the guide grooves 130 on the inner liner tube 200 correspond to the clamping protrusions 210 on the inner peripheral wall of the distal tube 111, and the clamping protrusions 210 slide in the guide groove 130, and the inner lining pipe 200 can be withdrawn from the proximal end of the operation part 120 .

Referring to FIGS. 8 and 9 , the aneurysm occlusion device is moved to the intracranial vascular aneurysm lesion, specifically, the arterial lateral wall aneurysm. The guidewire 400 is moved so that the guidewire 400 is inserted into the aneurysm 900 . The microcatheter 100 and the liner tube 200 are controlled to move together, so that the occlusion portion 110 of the microcatheter 100 protrudes into the aneurysm 900 , and the distal end of the liner tube 200 protrudes into the aneurysm 900 along with the microcatheter 100 .

Referring to FIGS. 10 and 11 , after the occlusion portion 110 of the aneurysm occlusion device is inserted into the aneurysm 900, before the liner tube 200 moves, the liner tube 200 is rotated to make the snap protrusions 210 and guide grooves on the liner tube 200 130 is dislocated, and then drives the distal end of the inner lining tube 200 to move toward the proximal end of the microcatheter 100 in the axial direction, and the snap protrusions 210 on the inner lining tube 200 drive the distal tube 111 to approach the proximal tube 112, thereby driving the mesh braided body 113 expands radially and occludes the neck of aneurysm 900. Plunger 800 is then filled into aneurysm 900 through the distal end of liner tube 200 . Rotate the inner liner tube 200 so that the snap protrusions 210 on the inner liner tube 200 correspond to the guide grooves 130 . At this time, the force of the mesh braid 113 on the operation part 120 and the force of the plunger 800 in the aneurysm 900 , keep it expanded. When the inner liner tube 200 is pulled, when the distal end of the inner liner tube 200 moves to the inside of the mesh braid 113 of the occlusion portion 110, the distal end of the inner liner tube 200 is filled with the plunger 800 toward the expanded occlusion portion 110, The neck of the aneurysm 900 is more effectively sealed by using the plunger 800 in the occlusion part 110 to maintain the expanded state of the occlusion part 110 .

Referring to FIG. 12 , after filling the occlusion portion 110 with the plunger 800, the liner tube 200 is pulled so that the inner liner tube 200 is withdrawn from the proximal end of the operation portion 120, and the operation portion 120 and the occlusion portion 110 are separated, and the guide wire is separated. 400 is withdrawn from within the occlusion 110, thereby implanting the occlusion at the neck of the aneurysm 900.

Referring to FIGS. 13 to 17 , the aneurysm occlusion device is moved to a lesion of an intracranial vascular aneurysm, specifically a non-lateral arterial aneurysm. The microcatheter 100 , the liner tube 200 and the guide wire 400 enter the human body under the action of the support catheter 300 , the guide wire 400 first enters the aneurysm 900 , and the microcatheter 100 and the liner tube 200 enter the artery under the action of the guide wire 400 Inside the tumor 900, the inner lining tube 200 is pulled to move, so that the snap protrusions 210 on the inner lining tube 200 drive the distal tube 111 to approach the proximal tube 112, so that the mesh braid 113 expands radially outward. The aneurysm 900 is filled with the plunger 800 through the liner tube 200, and then the liner tube 200 is rotated at a certain angle, so that the snap protrusions 210 on the liner tube 200 correspond to the guide grooves 130, and the mesh braid 113 The deployed state is maintained by the force of the operating portion 120 and the force of the plunger 800 in the aneurysm 900 . When the inner liner tube 200 is pulled, when the distal end of the inner liner tube 200 moves to the inside of the occlusion portion 110 , the distal end of the inner liner tube 200 is filled with the plunger 800 toward the expanded occlusion portion 110 to maintain the occlusion portion 110 . In the deployed state, the neck of the aneurysm 900 is more effectively sealed with the plunger 800 in the occlusion portion 110 . After filling the occlusion portion 110 with the plunger 800, the liner tube 200 is pulled so that the inner liner tube 200 is withdrawn from the proximal end of the operation portion 120, the operation portion 120 and the occlusion portion 110 are separated, and the guide wire 400 is removed from the occlusion portion 110 , thereby implanting the occlusion portion 110 at the neck of the aneurysm 900 .

18 to 32 are the second embodiment of the present invention:

Referring to FIGS. 18 and 19 , in this embodiment, the aneurysm occlusion device includes a microcatheter 100 , a liner tube 200 slidably penetrated through the microcatheter 100 , a support catheter 300 sleeved on the periphery of the microcatheter 100 , The guide wire 400 disposed in the inner liner tube 200 and the drawing wire 600 for driving the microcatheter 100 to expand in the radial direction.

For the structure and connection relationship of the support catheter 300 and the guide wire 400 in this embodiment, refer to the structure and connection relationship of the support catheter 300 and the guide wire 400 in the first embodiment, which will not be repeated here.

Referring to FIG. 18 to FIG. 21 , in this embodiment, the microcatheter 100 includes an obstructing part 110 and an operating part 120 detachably connected to the proximal end of the obstructing part 110 . The front end of the occlusion part 110 extends into the aneurysm 900 , the inner liner tube 200 is inserted into the occlusion part 110 , and the distal end of the occlusion part 110 is filled with a plunger 800 into the aneurysm 900 . The occlusion portion 110 is a tubular structure, and the middle portion of the occlusion portion 110 can be expanded radially outward to be expanded, and the occlusion portion 110 is expanded to block the neck of the aneurysm 900 .

In this embodiment, the blocking part 110 includes a distal tube 111 , a proximal tube 112 and a mesh braid 113 . The two axial ends of the mesh braid 113 are respectively connected to the distal tube 111 and the proximal tube 112 ; the mesh braid 113 can be expanded radially under the extrusion of the distal tube 111 and the proximal tube 112 .

The structure and connection relationship of the mesh braided body 113 in this embodiment can be referred to the structure and connection relationship of the mesh braided body 113 in the first embodiment, and will not be repeated here.

In this embodiment, the distal tube 111 , the proximal tube 112 and the operating portion 120 are not provided with the guide groove 130 , the proximal end of the distal tube 111 is provided with a groove 114 , and the peripheral walls of the proximal tube 112 and the operating portion 120 are A through guide hole 140 is provided along the axial direction, and the guide hole 140 communicates with the groove 114 .

In this embodiment, the operation part 120 is a tubular structure, the operation part 120 is a tubular structure in which the inner tube hole is communicated with the inner tube hole of the proximal tube 112 , and the distal end of the operation part 120 is detachably connected to the proximal end of the proximal tube 112 . end. The proximal end of the operating portion 120 protrudes from the proximal end of the support catheter 300 , so that the proximal end of the microcatheter 100 protrudes from the proximal end of the support catheter 300 .

In this embodiment, the operation part 120 and the proximal tube 112 are connected by a ring 500 made of a high-resolution electrolyte material, and the ring 500 is correspondingly provided with a guide hole 140 .

In some embodiments, the operation part 120 and the proximal tube 112 are detachably connected by other structures, and it is only necessary to ensure that the proximal tube 112 and the guide holes 140 on the operation part 120 can communicate with each other correspondingly.

In this embodiment, the distal end of the drawing wire 600 is fixedly connected in the groove 114 , and the drawing wire 600 passes through the proximal tube 112 and the operating portion 120 and passes through the proximal end of the operating portion 120 , so that the drawing wire 600 can be pulled at the proximal end of the operating portion 120 . The wire 600 is drawn so that the wire 600 drives the distal tube 111 to approach the proximal tube 112 , so that the mesh braid 113 expands and expands in the radial direction. The drawing wires 600 are located within the mesh braid 113 .

In some embodiments, the groove 114 is not provided on the distal tube 111, the distal end of the drawing wire 600 is fixed at any position of the distal tube 111, and it is only necessary to ensure that the drawing wire 600 can pull the distal tube 111 to be close to the proximal tube 112, i.e. Can.

In this embodiment, the drawing wire 600 passes through the guide hole 140 and passes out from the proximal end of the operation part 120 . In some embodiments, when the guide hole 140 is not provided, the drawing wire 600 can pass through the inside of the operation part 120 . For example, it passes through the gap between the operation part 120 and the inner lining pipe 200 .

The drawing wire 600 is a driving member for driving the distal tube 111 to move toward the proximal tube 112 ; the drawing wire 600 can be separated from the occlusion portion 110 . The drawing wire 600 is inserted into the guide hole 140 so that the drawing wires 600 will not intertwine and interfere with each other, and can ensure that when the drawing wire 600 pulls the distal tube 111 , the drawing wire 600 will not be twisted, and the pulling force on the distal tube 111 will be stable.

In this embodiment, the drawing wire 600 is a nickel-titanium wire, the distal end of which can be fused and separated from the distal tube 111 after electrification, so that the drawing wire 600 can be separated from the occluding part 110 after the filling of the aneurysm 900 and the occlusion part 110 is completed. , and extracted from the human body.

In this embodiment, two drawing wires 600 are provided, and the axes of the two drawing wires 600 and the distal tube 111 are in the same plane, so that the pulling force of the drawing wires 600 on the distal tube 111 is stable, and the deformation of the mesh braid 113 is stable and even. . In some embodiments, more than two wires 600 are provided.

Referring to FIGS. 18 to 22 , the liner tube 200 is a tubular structure, the liner tube 200 is slidably penetrated in the occlusion portion 110 , and the distal end of the liner tube 200 can move from the distal end of the occlusion portion 110 to the axial direction. The proximal end of the blocking part 110 is drawn out from the proximal end of the blocking part 110 and separated from the blocking part 110 .

In this embodiment, the inner lining pipe 200 has a straight tubular structure, the inner peripheral wall and the outer peripheral wall of the inner lining pipe 200 are both cylindrical structures, and the outer periphery of the inner lining pipe 200 is not provided with the clamping protrusions 210 .

In some embodiments, when the driving member is the drawing wire 600, the outer diameter of the lining tube 200 may be a polygonal structure such as a quadrilateral, pentagon, hexagon, etc. is the corresponding polygon structure.

Referring to Figures 23 and 24, the aneurysm occlusion device is moved to an intracranial vascular aneurysm lesion, specifically an arterial lateral wall aneurysm. The guidewire 400 is moved so that the guidewire 400 is inserted into the aneurysm 900 . The microcatheter 100 and the liner tube 200 are controlled to move together, so that the occlusion portion 110 of the microcatheter 100 protrudes into the aneurysm 900 , and the distal end of the liner tube 200 protrudes into the aneurysm 900 along with the microcatheter 100 .

25 and 26, after the occlusion portion 110 of the aneurysm occlusion device extends into the aneurysm 900, the drawing wire 600 is pulled to drive the distal tube 111 to approach the proximal tube 112, thereby driving the mesh braid 113 to expand radially Instead, it expands and plugs the neck of the aneurysm 900. Plunger 800 is then filled into aneurysm 900 through the distal end of liner tube 200 .

When the inner liner tube 200 is pulled, when the distal end of the inner liner tube 200 moves to the inside of the occlusion portion 110, the distal end of the inner liner tube 200 is filled with the plunger 800 toward the mesh braid 113 of the occluded portion 110 after deployment, The neck of the aneurysm 900 is more effectively sealed by using the plunger 800 in the occlusion part 110 to maintain the expanded state of the occlusion part 110 .

Referring to FIG. 27 , after the plunger 800 is filled into the mesh braid 113 of the occlusion portion 110 , the inner liner tube 200 is pulled so that the inner liner tube 200 is pulled out from the proximal end of the operation portion 120 , and the wire 600 and the distal tube 111 are drawn. The operation part 120 and the occlusion part 110 are separated, the guide wire 400 is pulled out from the occlusion part 110 , the drawing wire 400 and the operation part 120 are pulled out of the human body, and the occlusion part 110 is implanted at the neck of the aneurysm 900 .

Referring to Figures 28 to 32, the aneurysm occlusion device is moved to the lesion of an intracranial vascular aneurysm, specifically a non-lateral arterial aneurysm. The microcatheter 100, the lining tube 200, the guide wire 400 and the drawing wire 600 enter the human body under the action of the supporting catheter 300. 400 enters the aneurysm 900 under the guidance of the wire 600, and the wire 600 drives the distal tube 111 to approach the proximal tube 112, so that the mesh braid 113 expands radially outwards and expands. The aneurysm 900 is filled with the plunger 800 using the liner tube 200 . When the inner liner tube 200 is pulled, when the distal end of the inner liner tube 200 moves to the inside of the occlusion portion 110 , the distal end of the inner liner tube 200 is filled with the plunger 800 toward the expanded occlusion portion 110 to maintain the occlusion portion 110 . In the deployed state, the neck of the aneurysm 900 is more effectively sealed with the plunger 800 in the occlusion portion 110 . After filling the occlusion portion 110 with the plunger 800, the liner tube 200 is pulled so that the inner liner tube 200 is withdrawn from the proximal end of the operation portion 120, the drawing wire 600 and the distal tube 111 are separated, and the operation portion 120 and the occlusion portion 110 are separated After separation, the pull wire 600 and the guide wire 400 are withdrawn from the occlusion portion 110 so that the occlusion portion 110 is implanted at the neck of the aneurysm 900 .

33 to 34 are the third embodiment of the present invention:

Referring to FIG. 33 and FIG. 34 and the above-mentioned corresponding drawings, in this embodiment, the aneurysm occlusion device includes a microcatheter 100 , a liner tube 200 slidably penetrated through the microcatheter 100 , a The support catheter 300 , the guide wire 400 penetrated in the inner liner tube 200 , and the elastic sheet 700 that drives the microcatheter 100 to expand in the radial direction.

The microcatheter 100 includes an obstructing part 110 and an operating part 120 detachably connected to the proximal end of the obstructing part 110 . The front end of the occlusion part 110 extends into the aneurysm 900 , the inner liner tube 200 is inserted into the occlusion part 110 , and the distal end of the occlusion part 110 is filled with a plunger 800 into the aneurysm 900 . The occlusion portion 110 is a tubular structure, and the middle portion of the occlusion portion 110 can be expanded radially outward to be expanded, and the occlusion portion 110 is expanded to block the neck of the aneurysm 900 .

The occlusion portion 110 includes a distal tube 111 , a proximal tube 112 and a mesh braid 113 . The two axial ends of the mesh braid 113 are respectively connected to the distal tube 111 and the proximal tube 112 ; the mesh braid 113 can be expanded radially under the extrusion of the distal tube 111 and the proximal tube 112 .

In this embodiment, the lining tube 200 is used to fill the aneurysm 900 and the mesh braid 113 with the plunger 800 , and the outer periphery of the lining tube 200 is not provided with the snapping protrusions 210 .

The inner lining tube 200 is a tubular structure, the inner lining tube 200 is slidably penetrated in the blocking part 110 , and the distal end of the inner lining tube 200 can move from the distal end of the blocking part 110 to the proximal end of the blocking part 110 in the axial direction, And pulled out from the proximal end of the occlusion part 110 and separated from the occlusion part 110 . The proximal end of the liner tube 200 protrudes from the proximal end of the operating portion 120 .

For the structure and connection relationship of the operation part 120 in this embodiment, refer to the structure and connection relationship of the operation part 120 in the second embodiment, which will not be repeated here.

The elastic piece 700 is a driving member, and the elastic piece 700 can abut on the distal tube 111 to drive the distal tube 111 to move toward the proximal tube 112 ; the elastic piece 700 can be separated from the blocking part 110 .

In this embodiment, the elastic piece 700 is fixed at the distal end of the inner liner tube 120 , and the elastic piece 700 extends radially outward beyond the inner diameter of the distal end tube 111 .

Under a certain force, the elastic piece 700 can be elastically contracted in the distal tube 111 , the proximal tube 112 and the operation part 120 , so as to be able to be pulled out from the proximal end of the operation part 120 along with the inner lining tube 200 .

In this embodiment, in the natural state of the elastic piece 700 , the elastic piece 700 extends outward from the inner diameter of the distal end tube 111 in the radial direction of the distal end tube 111 , and the inner lining tube 200 is close to the inner lining tube 200 relative to the distal end tube 111 . When the end moves, the elastic piece 700 abuts on the distal end of the distal tube 112 , and drives the distal tube 111 to move close to the proximal tube 112 , so that the mesh braid 113 is unfolded. When the mesh braid 113 is unfolded, according to Hu Ke's law, the reverse elastic restoring force of the mesh braid 113 gradually increases. At this time, if the inner liner 200 continues to be moved, the elastic sheet 700 will deform and be under the tension of the inner liner 200. , retract under the distal tube 111 , continue to pull the inner lining tube 200 , the inner lining tube 200 drives the elastic piece 700 to pass through the proximal tube 112 and the operation part 120 in sequence, so that the elastic piece 700 follows the inner lining tube 200 from the operating part 120 end pulled out.

In this embodiment, the microcatheter 100 , the inner liner 200 , the guide wire 400 and the shrapnel 700 enter the human body under the action of the supporting catheter 300 . The elastic piece 700 enters the aneurysm 900 under the action of the guide wire 400 and pulls the lining tube 200. The elastic piece 700 drives the distal tube 111 to approach the proximal tube 112, so that the mesh braid 113 expands radially outward. After the mesh braid 113 is unfolded to a certain extent, the inner lining tube 200 fills the aneurysm 900 with the plunger 800 , and then continues to pull the inner lining tube 200 , the elastic pieces 700 are deformed and retracted under the pulling force of the inner lining tube 200 Into the distal end tube 111 , continue to pull the inner liner tube 200 , so that the distal end of the inner liner tube 200 moves into the mesh braid 113 of the occlusion portion 110 . At this time, the mesh braid 113 is maintained in the expanded state by the force of the operation part 120 and the force of the plunger 800 in the aneurysm 900 . After the distal end of the inner liner tube 200 moves to the inside of the mesh braid 113 of the occlusion portion 110 , the distal end of the inner liner tube 200 is filled with the plunger 800 toward the deployed occlusion portion 110 to maintain the deployment of the occlusion portion 110 . state, and then pull the liner tube 200, so that the liner tube 200 and the elastic piece 700 are pulled out from the proximal end of the operation part 120, and the operation part 120 and the occlusion part 110 are separated, and the guide wire 400 is pulled out from the occlusion part 110, so that the The occlusion 110 is implanted at the neck of the aneurysm 900 .

Fourth embodiment:

35 , in this embodiment, the aneurysm occlusion device includes a microcatheter 100 , a liner tube 200 slidably penetrated through the microcatheter 100 , a support catheter 300 sleeved on the periphery of the microcatheter 100 , and the guide wire 400 passing through the inner lining tube 200 .

The microcatheter 100 includes an obstructing part 110 and an operating part 120 detachably connected to the proximal end of the obstructing part 110 . The front end of the occlusion part 110 extends into the aneurysm 900 , the inner liner tube 200 is inserted into the occlusion part 110 , and the distal end of the occlusion part 110 is filled with a plunger 800 into the aneurysm 900 .

In this embodiment, the operation part 120 is a tubular structure, the operation part 120 is a tubular structure in which the inner tube hole is communicated with the inner tube hole of the proximal tube 112 , and the distal end of the operation part 120 is detachably connected to the proximal end of the proximal tube 112 . end. The proximal end of the operating portion 120 protrudes from the proximal end of the support catheter 300 , so that the proximal end of the microcatheter 100 protrudes from the proximal end of the support catheter 300 . In this embodiment, the inner peripheral walls of the operation portion 120 , the distal tube 111 and the proximal tube 112 are not provided with the guide groove 130 , and the inner periphery of the distal tube 111 is provided with an axially penetrating helical groove 150 .

In this embodiment, the distal tube 111 is provided with a threaded hole, and a helical groove 150 is formed on the inner peripheral wall of the distal tube. In some embodiments, the helical groove 150 is a hole with a cross-section of other shapes, such as a rectangle or a triangle.

The outer peripheral wall of the distal end of the inner liner tube 200 is protruded with helical teeth 220 to form a driving member, and the helical teeth 220 can slide in the helical groove 150 . The helical tooth 220 is a deformed snap protrusion 210 , and the helical groove 150 is a deformed guide groove 130 .

In this embodiment, the screw thread 220 is a thread thread, and the thread thread is matched with the thread hole on the distal end tube 111 .

The outer diameter of the helical teeth 220 is larger than the inner diameter of the distal tube 111 , so that the helical teeth 220 can abut on the distal end of the distal tube 111 . The proximal end of the inner liner tube 200 protrudes from the proximal end of the operating portion 120 , the proximal end of the inner liner tube 200 pulls the inner liner tube 200 to move relative to the microcatheter 100 , and the spiral teeth 220 on the outer circumference of the inner liner tube 200 drive the distal tube 111 moves toward proximal tube 112, causing mesh braid 113 to unfold. The inner peripheries of the proximal tube 112 and the manipulation portion 120 extend radially outward beyond the helical teeth 220 so that the helical teeth 220 can be withdrawn from the proximal end of the manipulation portion 120 with the liner tube 200 .

In some embodiments, the helical grooves 150 are provided on the liner tube 200 , and the helical teeth 220 are provided on the distal tube 111 . That is, the outer peripheral wall of the distal end of the inner liner tube 200 is provided with a spiral groove 150, and the spiral groove 150 extends to the end face of the distal end of the inner liner tube 200; the inner peripheral wall of the distal end tube 111 is protruded with spiral teeth 220 to form a driving member; The helical teeth 220 can slide within the helical groove 150 . The inner liner tube 200 may be a straight tube, and the outer peripheral wall of the distal end is machined with a spiral groove 150 , and the inner peripheral wall of the distal end tube 111 is protruded to form a thread thread 220 .

In this embodiment, the helical teeth 220 are slidably disposed in the helical grooves 150 , so that the inner lining tube 200 can rotate relative to the distal tube 111 , so that the distal end of the inner lining tube 200 can be retracted into the mesh braid 113 .

In this embodiment, when the inner lining tube 200 is unscrewed from the distal tube 111, the mesh braid 113 may be twisted under the driving of the distal tube 111. When the twist is to a certain extent, the mesh braid 113 may twist. The reverse elastic force is greater than the torsion force of the inner lining tube 200 on the distal tube 111 , so that the inner lining tube 200 can be smoothly separated from the spiral groove 150 . After the inner liner 200 is separated from the spiral groove 150 , the inner liner 200 is filled with the plunger 800 into the mesh braid 113 . In addition, after the inner lining tube 200 is separated from the helical groove 150, the mesh braided body 113 is restored from the torsional deformation state to the normal expanded state based on the shape memory effect and elastic deformation.

In this embodiment, the microcatheter 100 , the inner liner 200 and the guide wire 400 enter the human body under the action of the supporting catheter 300 , the guide wire 400 enters the aneurysm 900 first, and the microcatheter 100 and the inner liner 200 are inserted into the guide wire 400 into the aneurysm 900 under the action. When the inner liner tube 200 is pulled, the helical teeth 220 on the inner liner tube 200 drive the distal tube 111 to approach the proximal tube 112 , so that the mesh braid 113 expands radially outwards and expands. The lining tube 200 fills the aneurysm 900 with the plunger 800, and then the lining tube 200 is rotated so that the helical teeth 220 of the lining tube 200 slide within the spiral grooves 150 of the distal tube 111, and the distal end of the lining tube 200 It is retracted into the mesh knitted body 113 of the occlusion portion 110 . At this time, the mesh braid 113 is maintained in the expanded state by the force of the operation part 120 and the force of the plunger 800 in the aneurysm 900 . After the distal end of the inner liner tube 200 moves to the inside of the occlusion portion 110, the distal end of the inner liner tube 200 is filled with the plunger 800 toward the expanded occlusion portion 110 to maintain the expanded state of the occlusion portion 110, and then the inner portion is pulled. The liner tube 200 is withdrawn from the proximal end of the operation part 120, the operation part 120 and the occlusion part 110 are separated, the guide wire 400 is withdrawn from the occlusion part 110, and the occlusion device is implanted into the aneurysm 900. at the neck.

In some embodiments, the mesh braid 113 has memory capability, the distal end of the inner lining tube 200 is clamped to the distal tube 111 , and the inner lining tube 200 has a pulling force on the distal tube 111 toward the distal end of the distal tube 111 . , the operating part 120 has a pulling force towards the proximal end of the proximal tube 112 , and the mesh braid 113 is kept in a retracted state under the force of the inner lining tube 200 and the operating part 120 . Remove the pulling force of the inner liner tube 200 or the operation part 120 to remove the mesh braid 113, the mesh braid 113 is unfolded under the memory ability, and the aneurysm 900 and the mesh braid 113 are filled with the column through the liner tube 200 Stuff 800.

In the present invention, after the occlusion part 110 extends into the aneurysm, the middle part of the occlusion part 110 can be expanded radially outward to block the neck of the aneurysm; the operation part 120 and the occlusion part 110 are detachably connected, so that the After the operation part 120 is separated from the occlusion part 110 , the operation part 120 can keep the occlusion part 110 at the neck of the aneurysm. The tubular structure of the occlusion part 110 can fill the aneurysm with a plunger through the occlusion part 110 to fill the aneurysm; and the occlusion part 110 can be filled with a plunger, maintain the expanded state of the occlusion part 110, and use the occlusion part The plunger in 110 seals the neck of the aneurysm more effectively to prevent or reduce the flow of blood from the aneurysm, so that an effective thrombus can be quickly formed inside the sealed aneurysm, and the formed thrombus can be prevented from flowing in the bloodstream. Dissolves under impact to improve therapeutic effect.

Further, both the inner liner tube 200 and the operation part 120 can be separated from the occlusion part 110, so that after the occlusion part 110 is implanted into the aneurysm 900 alone, the blood flow in the vessel will not be affected.

While the present invention has been described with reference to several exemplary embodiments, it is to be understood that the terminology used is of description and illustration, and not of limitation. Since the invention can be embodied in many forms without departing from the spirit or spirit of the invention, it is to be understood that the above-described embodiments are not limited to any of the foregoing details, but are to be construed broadly within the spirit and scope defined by the appended claims Therefore, all changes and modifications that come within the scope of the claims or their equivalents should be covered by the appended claims.

Claims

A microcatheter, characterized in that, comprising:

an occlusion part, which is a tubular structure, and the middle part of the occlusion part can be expanded radially outward to expand;

an operating part, the distal end of which is detachably connected to the proximal end of the blocking part, so as to disengage the blocking part when the blocking part is unfolded.
The microcatheter according to claim 1, wherein the occlusion part comprises a distal tube, a proximal tube and a mesh braid; two ends of the mesh braid are respectively connected to the distal tube and the mesh braid. on the proximal tube; the mesh braid can be expanded radially under the extrusion of the distal tube and the proximal tube; the proximal end of the proximal tube is detachably connected to the on the operating unit.
The microcatheter according to claim 2, wherein a ring is connected between the distal end of the operating portion and the proximal end of the proximal tube, and the ring is made of a polymer electrolyte material.
An aneurysm occlusion device, comprising:

The microcatheter comprises an occlusion part and an operation part; the occlusion part is a tubular structure, and the middle part of the occlusion part can be expanded radially outwardly to be expanded; the distal end of the operation part is detachably connected to the occlusion part a proximal end for disengaging the occlusion portion when the occlusion portion is deployed;

an inner liner tube slidably penetrated in the occlusion part; the distal end of the liner tube can move axially from the distal end of the occlusion part to the proximal end of the occlusion part, and from the occlusion part The proximal end of the part is withdrawn.
The aneurysm occlusion device according to claim 4, wherein the occlusion part comprises a distal tube, a proximal tube and a mesh braid; two ends of the mesh braid are respectively connected to the distal end tube and the proximal tube; the mesh braid can be expanded radially under the extrusion of the distal tube and the proximal tube; the proximal end of the proximal tube is detachably connected to the on the operating unit.
The aneurysm occlusion device according to claim 5, wherein a ring is connected between the distal end of the operating portion and the proximal end of the proximal tube, and the ring is made of polymer electrolyte material .
The aneurysm occlusion device according to claim 5 or 6, wherein the aneurysm occlusion device further comprises a driving member, and the driving member can be fixed or abutted on the distal tube to drive the aneurysm. The distal tube moves toward the proximal tube; the driver is separable from the occlusion portion to move from the distal end of the occlusion portion to the proximal end of the occlusion portion and from the proximal end of the occlusion portion draw out.
The aneurysm occlusion device according to claim 7, wherein the outer peripheral wall of the distal end of the inner lining tube is protruded with a locking protrusion to form the driving member, and the locking protrusion can be connected with the distal tube The distal end of the micro-catheter is in contact with each other; the inner peripheral wall of the operating part, the distal tube and the proximal tube is correspondingly provided with a guide groove that penetrates in the axial direction; slide in the guide groove.
The aneurysm occlusion device according to claim 8, wherein a step is formed on the inner side of the distal end of the distal tube, and the snap protrusion can be overlapped on the step, so that the snap protrusion can drive the The proximal tube approaches toward the distal tube.
The aneurysm occlusion device according to claim 7, wherein the lining tube comprises a main body portion at the proximal end and a fitting portion at the distal end, and the radial dimension of the fitting portion is larger than the radial dimension of the main body portion. The outer peripheral wall of the matching portion is provided with a guide groove that penetrates in the axial direction; the inner peripheral wall of the distal tube is protruded with a locking protrusion to form the driving member, and the locking protrusion can be used in the guide. Sliding in the slot.
The aneurysm occlusion device according to claim 7, wherein the inner circumference of the distal tube is provided with an axially penetrating helical groove; The driving member is formed, and the helical teeth can slide in the helical grooves; the inner circumference of the proximal tube and the operating portion are radially outward beyond the helical teeth, so that the helical teeth can follow the helical teeth. The liner tube is withdrawn from the proximal end of the operating portion.
The aneurysm occlusion device according to claim 7, wherein the outer peripheral wall of the distal end of the inner lining tube is provided with a spiral groove, and the spiral groove extends to the end face of the distal end of the inner lining tube; the The inner peripheral wall of the distal tube is protruded with helical teeth to form the driving member; the helical teeth can slide in the helical groove.
The aneurysm occlusion device according to claim 11 or 12, wherein the helical teeth are threaded teeth, and the distal tube is provided with a threaded hole to form the inner peripheral wall of the distal tube. Spiral groove.
The aneurysm occlusion device according to claim 7, wherein the driving member is a drawing wire, the drawing wire is connected to the distal tube, and the drawing wire passes through the proximal tube and the operating portion And pass out from the proximal end of the operation part.
The aneurysm occlusion device according to claim 14, wherein the micro-catheter is provided with a guide hole axially penetrating the proximal tube and the operation part, and the drawing wire is passed through the guide hole .
The aneurysm occlusion device according to claim 14, wherein there are at least two drawing wires, and the axes of the at least two drawing wires are in the same plane as the axis of the distal tube.
The aneurysm occlusion device according to claim 14, wherein the proximal end of the distal tube is provided with a groove, and the drawing wire is fixed in the groove.
The aneurysm occlusion device according to claim 14, wherein the drawing wire is a nickel-titanium wire, the distal end of which can be fused and separated from the distal tube after being electrified.
The aneurysm occlusion device according to claim 7, wherein the driving member is an elastic sheet, and the elastic sheet is fixed at the distal end of the inner lining tube; the elastic sheet extends radially outward beyond the distal end The inner diameter of the tube; the elastic piece can be elastically contracted in the distal tube, the proximal tube and the operating portion, so as to be able to be pulled out from the proximal end of the operating portion along with the inner lining tube.
The aneurysm occlusion device according to any one of claims 4-19, wherein the operating portion is a tubular structure in which an inner tube hole communicates with an inner tube hole at the proximal end of the occlusion portion; the lining tube It is slidably penetrated in the blocking part and the operating part.