WO2022139747A1 - Solution provided with antimicrobial property and skin product manufactured from the product to which said solution is applied - Google Patents
Solution provided with antimicrobial property and skin product manufactured from the product to which said solution is applied Download PDFInfo
- Publication number
- WO2022139747A1 WO2022139747A1 PCT/TR2021/051265 TR2021051265W WO2022139747A1 WO 2022139747 A1 WO2022139747 A1 WO 2022139747A1 TR 2021051265 W TR2021051265 W TR 2021051265W WO 2022139747 A1 WO2022139747 A1 WO 2022139747A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- active ingredient
- solution
- nonwoven fabric
- trimethoxysilylpropyl
- ammonium chloride
- Prior art date
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 23
- 239000004480 active ingredient Substances 0.000 claims abstract description 42
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000004744 fabric Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims description 56
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 14
- WSFMFXQNYPNYGG-UHFFFAOYSA-M dimethyl-octadecyl-(3-trimethoxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OC)(OC)OC WSFMFXQNYPNYGG-UHFFFAOYSA-M 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 11
- 235000019270 ammonium chloride Nutrition 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000005470 impregnation Methods 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 description 11
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 11
- 229920000297 Rayon Polymers 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 239000006087 Silane Coupling Agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000000962 organic group Chemical group 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000433 Lyocell Polymers 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229960003093 antiseptics and disinfectants Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- XKXHCNPAFAXVRZ-UHFFFAOYSA-N benzylazanium;chloride Chemical compound [Cl-].[NH3+]CC1=CC=CC=C1 XKXHCNPAFAXVRZ-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229960001915 hexamidine Drugs 0.000 description 1
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Definitions
- the subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric.
- the skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted.
- the skin is an important part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein.
- the need to clean our hands or face is today commonly satisfied still by the use of wet wipes.
- the wet wipes are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used in the restaurants, schools and even in hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
- the wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and being free of the products likely to threaten the human health.
- the ingredients of the wet wipes intended for skin cleansing the use of which becomes a need and even more widespread especially in the periods of disease and epidemics, has become even more important, since these are the products being exposed to by a greater extent in such periods.
- the wet wipes are obtained by way of impregnation of the nonwoven fabrics with a solution having generally high water content.
- a nonwoven fabric is subjected to treatment with a solution with high water content, more than one preservative agent (hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.) with the possibility of providing action against different microorganisms (bacteria, mould, yeast) are added to the wet wipe solutions usually at high ratios such that no microbiological growth occurs.
- preservative agent hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.
- Nonwoven fabric is a fabric-like material made from short and long (continuous long) fibers, bonded together by chemical, mechanical, heat or solvent treatment.
- the term is used in the textile manufacturing industry to denote fabrics, such as felt, which are neither woven nor knitted.
- Various natural and/or synthetic staples called fiber may be used as the raw material in the nonwoven fabrics. Natural fibers may include cotton, viscose and viscose types such as lyocell. There is a broad array of synthetic fibers, and polyester, polyethylene and polypropylene are among the most frequently encountered. These fibers may be used alone (e.g.
- 100% cotton, 100% polypropylene, etc.) or more than one type of fiber may be combined at various proportions (mixture 20% viscose and 80% polyester) for the manufacture of the nonwoven fabrics.
- Various methods are available for the manufacture of the nonwoven fabrics, including dry laid processes, wet laid processes and spun laid processes, the latter involving the melting of the polymer. Although it is attempted in all the methods to obtain a sterile product by subjecting the fibers that are to be used and the nonwoven fabrics that are obtained to various treatments, it is not possible to obtain these in a perfectly sterile manner as a result of the processes performed according to the state of the art.
- the preservatives used in the solutions applied to the nonwoven fabrics for obtaining the skin products such as wet wipes lead to the odor and color change in the product, in addition to their harmful effects on the skin.
- solutions and the method according to the invention have been developed in order to eliminate the preservatives employed in great numbers and in high concentrations according to the state of the art and in order to obtain a skin product, preferably a wet wipe, provided with antimicrobial property without such preservatives being added to the solution.
- An object of the invention is to develop a solution that is to be applied to a nonwoven fabric and to provide antimicrobial property to the fabric.
- Another object of the invention is to develop a skin product with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated when obtaining said skin product.
- Another object of the invention is to develop a wet wipe with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated.
- the subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric.
- the solution developed within the scope of the invention comprises at least one active ingredient, which provides the antimicrobial property, and the water.
- the inhibitory concentrations of some raw active ingredients against the bacteria, fungi and algae were examined.
- Table 1 Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the bacteria
- Table 2 Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the fungi
- Quaternary ammonium compounds are among the known effective antiseptics and disinfectants. When these agents are fixed on a material surface, they cause the death of the bacterial cells through the cationic quaternary group and/or long-chain alkyl group. While the cationic quaternary group kills the cell by causing the attached cell membrane to lose its ionic balance, the long-chain alkyl group realizes the cell death by penetrating the membrane to physically disrupt the cell. In addition to their bactericidal action, the quaternary ammonium compounds are known to exhibit activity against the yeasts, spores and viruses.
- the silane coupling agents are used to modify the surface of various materials.
- the functional organic groups are modified by forming bonds with the molecules of the silane coupling agent and the coupling agent molecules are fixed on the material surface.
- the surface modified in this way gains the properties originating from the added organic group. Owing to the silane coupling agents modified with the quaternary ammonium compounds, the antibacterial property may be provided to the desired surfaces.
- the solutions developed within the scope of the invention comprise at least one active ingredient at a ratio of 0.05-0.2% by weight and water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.
- the use of at least one active ingredient selected from dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and n,n-dimethyl-n-dodecyl- n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
- An alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.1-0.2% by weight.
- dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
- Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.09-0.15% by weight.
- dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
- Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.03-0.06% by weight.
- dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
- the nonwoven fabrics are subjected to treatment with the solution according to the invention.
- the weight of one piece of dry tissue is determined by performing calculations based on a nonwoven fabric with known dimensions (width and length) and weight (g/m2) and the amount of solution to be applied to the fabrics is determined.
- the determined amount of nonwoven fabric solution is applied to the nonwoven fabrics and then the fabrics are dried.
- the fabrics are dried preferably in a drying oven.
- the application of the solutions developed within the scope of the invention to the nonwoven fabrics may be through any method preferred.
- treatment of the fibers with the solutions according to the invention may be realized by way of spraying after the manufacture of the fibers or a similar technique involving the spraying on the fibers.
- the compositions according to the invention may be applied to the nonwoven fabrics by way of adding the fabric to the active ingredient-containing solutions via the wet laid method or applying the solutions on the fabric surface via said method or a different method, e.g. injection or spraying, followed by the drying process.
- the molecular structure of the natural fibers such as viscose and cotton is in the form of cellulose-OH. Unlike the cotton, the viscose does not contain impurities.
- the viscose is obtained by various chemical processes starting from wood cellulose and cotton linters.
- the ingredient dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI) one of the active ingredients used within the scope of the invention, adheres onto the surface by forming bonds with hydroxyl terminals present on the surface of viscose.
- DTSACI dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride
- the antimicrobial property is provided to the fabric upon the active ingredient adhering to -OH molecules present on the surface, owing to the cellulosic structure of the fabric.
- the skin product obtained from the nonwoven fabric which is provided with antimicrobial property within the scope of the invention, is also included in the scope of the invention.
- the skin product developed within the scope of the invention is preferably a wet wipe.
- the prepared wet wipe solution is applied to the wet wipes based on the amount of solution to be transferred to 1 piece of dry tissue according to the wetting factor for impregnating the nonwoven fabric with the nonwoven fabric solution according to the invention.
Abstract
The subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric. The solutions developed within the scope of the invention comprise at least one active ingredient at a ratio of 0.05-0.2% by weight and water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.
Description
SOLUTION PROVIDED WITH ANTIMICROBIAL PROPERTY AND SKIN PRODUCT MANUFACTURED FROM THE PRODUCT TO WHICH SAID SOLUTION IS APPLIED
Subject of the Invention
The subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric.
State of the Art
The skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted. Besides, the skin is an important part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein.
It is of importance to clean especially our hands with the skin products containing suitable antimicrobial agents, in order to minimize the risk of transmitting the microorganisms our hands are exposed to.
In the ambiences such as travel ambience where to make use of water is not immediately possible or in the ambiences such as public transport where the hygienic conditions are not appropriate, the need to clean our hands or face is today commonly satisfied still by the use of wet wipes. The wet wipes, the use of which has become quite widespread, are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used in the restaurants, schools and even in hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.
The wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and being free of the products likely to threaten the human health. The ingredients of the wet wipes intended for skin cleansing, the use of which becomes a need and even more widespread especially in the periods of disease and epidemics, has become even more important, since these are the products being exposed to by a greater extent in such periods.
The wet wipes are obtained by way of impregnation of the nonwoven fabrics with a solution having generally high water content. When a nonwoven fabric is subjected to treatment with
a solution with high water content, more than one preservative agent (hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.) with the possibility of providing action against different microorganisms (bacteria, mould, yeast) are added to the wet wipe solutions usually at high ratios such that no microbiological growth occurs. However, when the products according to the state of the art are used, the skin problems such as skin irritation, etc. occur, and further, the toxic effects emerge as a result of using the strong preservatives, depending on the concentrations and types of the preservatives such products contain.
Nonwoven fabric is a fabric-like material made from short and long (continuous long) fibers, bonded together by chemical, mechanical, heat or solvent treatment. The term is used in the textile manufacturing industry to denote fabrics, such as felt, which are neither woven nor knitted. Various natural and/or synthetic staples called fiber may be used as the raw material in the nonwoven fabrics. Natural fibers may include cotton, viscose and viscose types such as lyocell. There is a broad array of synthetic fibers, and polyester, polyethylene and polypropylene are among the most frequently encountered. These fibers may be used alone (e.g. 100% cotton, 100% polypropylene, etc.) or more than one type of fiber may be combined at various proportions (mixture 20% viscose and 80% polyester) for the manufacture of the nonwoven fabrics. Various methods are available for the manufacture of the nonwoven fabrics, including dry laid processes, wet laid processes and spun laid processes, the latter involving the melting of the polymer. Although it is attempted in all the methods to obtain a sterile product by subjecting the fibers that are to be used and the nonwoven fabrics that are obtained to various treatments, it is not possible to obtain these in a perfectly sterile manner as a result of the processes performed according to the state of the art.
The preservatives used in the solutions applied to the nonwoven fabrics for obtaining the skin products such as wet wipes lead to the odor and color change in the product, in addition to their harmful effects on the skin.
The solutions and the method according to the invention have been developed in order to eliminate the preservatives employed in great numbers and in high concentrations according to the state of the art and in order to obtain a skin product, preferably a wet wipe, provided with antimicrobial property without such preservatives being added to the solution.
Object of the Invention
An object of the invention is to develop a solution that is to be applied to a nonwoven fabric and to provide antimicrobial property to the fabric.
Another object of the invention is to develop a skin product with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated when obtaining said skin product.
Another object of the invention is to develop a wet wipe with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated.
Description of the Tables
Table 1: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the bacteria
Table 2: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the fungi
Table 3: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the algae
Table 4: Results of antimicrobial test for dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI) (7,12%)
Description of the Invention
The subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric.
The solution developed within the scope of the invention comprises at least one active ingredient, which provides the antimicrobial property, and the water.
For the purpose of developing an effective solution within the scope of the invention, the inhibitory concentrations of some raw active ingredients against the bacteria, fungi and algae were examined.
Table 1: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the bacteria
Table 2: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the fungi
Table 3: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the algae
Quaternary ammonium compounds (also commonly known as quats or QACs) are among the known effective antiseptics and disinfectants. When these agents are fixed on a material surface, they cause the death of the bacterial cells through the cationic quaternary group and/or long-chain alkyl group. While the cationic quaternary group kills the cell by causing the attached cell membrane to lose its ionic balance, the long-chain alkyl group realizes the cell death by penetrating the membrane to physically disrupt the cell. In addition to their bactericidal action, the quaternary ammonium compounds are known to exhibit activity against the yeasts, spores and viruses. It was observed in the conducted studies that the antimicrobial action of the quaternary ammonium compounds varied according to the structure of the compounds. The compound
poly[trialkyl(vinylbenzyl)ammonium chloride] was observed to have a greater antimicrobial effect against the bacteria and fungi than the monomer form of said compound. In the studies performed with the compound alkyldimethyl benzyl ammonium chloride (ADBAC) having different numbers of carbon atoms, it was observed that increasing the number of carbons up to C12 and C14 has an increasing effect on the activity, but the activity decreases when C14 is exceeded.
The silane coupling agents are used to modify the surface of various materials. The functional organic groups are modified by forming bonds with the molecules of the silane coupling agent and the coupling agent molecules are fixed on the material surface. The surface modified in this way gains the properties originating from the added organic group. Owing to the silane coupling agents modified with the quaternary ammonium compounds, the antibacterial property may be provided to the desired surfaces.
The results of the antimicrobial test for the compound dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride (DTSACI), a silane coupling agent from the quaternary ammonium compounds, which was examined in a study within the scope of the invention, are shown in Table 4 below.
Table 4: Results of antimicrobial test for dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI) (7,12%)
The active ingredients possible to be used within the scope of the invention were identified as a result of the studies performed and the solutions according to the invention were developed by using said active ingredients at appropriate ratios in combination with water.
The solutions developed within the scope of the invention comprise at least one active ingredient at a ratio of 0.05-0.2% by weight and water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.
Within the scope of the invention, the use of at least one active ingredient selected from dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and n,n-dimethyl-n-dodecyl- n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
An alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.1-0.2% by weight. In said embodiment, dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.09-0.15% by weight. In said embodiment, dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.03-0.06% by weight. In said embodiment, dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.
After the solutions developed within the scope of the invention are prepared, the nonwoven fabrics are subjected to treatment with the solution according to the invention. The weight of one piece of dry tissue is determined by performing calculations based on a nonwoven fabric with known dimensions (width and length) and weight (g/m2) and the amount of solution to be applied to the fabrics is determined. The determined amount of nonwoven fabric solution is applied to the nonwoven fabrics and then the fabrics are dried. The fabrics are dried preferably in a drying oven.
The application of the solutions developed within the scope of the invention to the nonwoven fabrics may be through any method preferred. For example, treatment of the fibers with the solutions according to the invention may be realized by way of spraying after the manufacture of the fibers or a similar technique involving the spraying on the fibers. As for the nonwoven fabrics, the compositions according to the invention may be applied to the nonwoven fabrics by way of adding the fabric to the active ingredient-containing solutions via the wet laid method or applying the solutions on the fabric surface via said method or a different method, e.g. injection or spraying, followed by the drying process.
The molecular structure of the natural fibers such as viscose and cotton is in the form of cellulose-OH. Unlike the cotton, the viscose does not contain impurities. The viscose is obtained by various chemical processes starting from wood cellulose and cotton linters. The ingredient dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI), one of the active ingredients used within the scope of the invention, adheres onto the surface by forming bonds with hydroxyl terminals present on the surface of viscose.
As a result of application of the solutions developed within the scope of the invention to the nonwoven fabrics, the antimicrobial property is provided to the fabric upon the active ingredient adhering to -OH molecules present on the surface, owing to the cellulosic structure of the fabric.
The skin product obtained from the nonwoven fabric, which is provided with antimicrobial property within the scope of the invention, is also included in the scope of the invention.
The skin product developed within the scope of the invention is preferably a wet wipe. In order to obtain the finished skin product, the prepared wet wipe solution is applied to the wet wipes based on the amount of solution to be transferred to 1 piece of dry tissue according to the wetting factor for impregnating the nonwoven fabric with the nonwoven fabric solution according to the invention.
Owing to the application of the solutions developed within the scope of the invention to the nonwoven fabrics and owing to the wet wipes manufactured from said fabrics, there is left no need to add a separate preservative to the solution with which the fabric is impregnated for manufacturing the wet wipe, and as a result, the adverse effects of the preservatives, used in great numbers and in high concentrations, on the human health are eliminated as well as removing the problem of odor and color change encountered when such preservatives are added to the water with which the fabric is treated.
Claims
1. A solution, which is to be applied to a nonwoven fabric during the manufacture of the same for obtaining a skin product provided with antimicrobial property and which is to enable a nonwoven fabric provided with antimicrobial property to be obtained, characterized in that the solution comprises
• at least one active ingredient, which provides antimicrobial property, at a ratio of 0.05- 0.2% by weight and
• water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.
2. A solution according to Claim 1 characterized in that said active ingredient is at least one active ingredient selected from dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and n,n-dimethyl-n-dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.
3. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.1-0.2% by weight and said active ingredient is dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride.
4. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.1-0.2% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.
5. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.09-0.15% by weight and said active ingredient is dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride.
6. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.09-0.15% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.
7. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.03-0.06% by weight and said active ingredient is dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride.
8. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.03-0.06% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.
9. A skin product characterized in that the skin product is manufactured from a nonwoven fabric containing a solution according to any one of the preceding claims.
10. A skin product according to Claim 9 characterized in that the skin product is a wet wipe.
8
11. A method for obtaining the skin product characterized in that the method comprises the process steps of
• applying a determined quantity of the nonwoven fabric solution according to the invention to the nonwoven fabric, • drying the nonwoven fabric, and
• treating the nonwoven fabric with the wet wipe solution in a quantity determined according to the wetting factor for impregnation of the nonwoven fabric with the nonwoven fabric solution in the first step and thereby obtaining the wet wipe.
12. A method according to Claim 11 characterized in that the process of application of the nonwoven fabric solution to the nonwoven fabric is realized by way of adding the fabric to the active ingredient-containing solutions via the wet laid method, by way of performing at least one of the spraying or injection methods or by way of performing at least one of the methods of spraying or injection on the fibers from which the nonwoven fabrics are obtained.
13. A method according to Claim 11 characterized in that the nonwoven fabric is dried in a drying oven.
9
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2020/21791A TR202021791A2 (en) | 2020-12-25 | 2020-12-25 | A SKIN PRODUCT MADE OF AN ANTIMICROBIAL SOLUTION AND THE PRODUCT TO WHICH THIS SOLUTION IS APPLIED |
TR2020/21791 | 2020-12-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022139747A1 true WO2022139747A1 (en) | 2022-06-30 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/TR2021/051265 WO2022139747A1 (en) | 2020-12-25 | 2021-11-22 | Solution provided with antimicrobial property and skin product manufactured from the product to which said solution is applied |
Country Status (2)
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TR (1) | TR202021791A2 (en) |
WO (1) | WO2022139747A1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120080693A (en) * | 2011-01-09 | 2012-07-18 | 황인정 | Method of manufacturing wet tissue with long term antimicrobial and anti-fongus efficacy |
US20140011766A1 (en) * | 2012-01-24 | 2014-01-09 | Randall W. Krafft | Antimicrobial compositions and methods |
US20180243790A1 (en) * | 2011-04-15 | 2018-08-30 | Allied Bioscience, Inc. | Wet wipes comprising antimicrobial coating compositions |
JP2019097756A (en) * | 2017-11-30 | 2019-06-24 | 株式会社ニイタカ | Wet wiper |
-
2020
- 2020-12-25 TR TR2020/21791A patent/TR202021791A2/en unknown
-
2021
- 2021-11-22 WO PCT/TR2021/051265 patent/WO2022139747A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120080693A (en) * | 2011-01-09 | 2012-07-18 | 황인정 | Method of manufacturing wet tissue with long term antimicrobial and anti-fongus efficacy |
US20180243790A1 (en) * | 2011-04-15 | 2018-08-30 | Allied Bioscience, Inc. | Wet wipes comprising antimicrobial coating compositions |
US20140011766A1 (en) * | 2012-01-24 | 2014-01-09 | Randall W. Krafft | Antimicrobial compositions and methods |
JP2019097756A (en) * | 2017-11-30 | 2019-06-24 | 株式会社ニイタカ | Wet wiper |
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