WO2022132161A1 - Dispositif d'attache intestinale - Google Patents

Dispositif d'attache intestinale Download PDF

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Publication number
WO2022132161A1
WO2022132161A1 PCT/US2020/065823 US2020065823W WO2022132161A1 WO 2022132161 A1 WO2022132161 A1 WO 2022132161A1 US 2020065823 W US2020065823 W US 2020065823W WO 2022132161 A1 WO2022132161 A1 WO 2022132161A1
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
ppg
flange
attachment device
sensor
Prior art date
Application number
PCT/US2020/065823
Other languages
English (en)
Inventor
Benjamin D. Pless
Daniel BACHER
Original Assignee
Celero Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celero Systems, Inc. filed Critical Celero Systems, Inc.
Priority to PCT/US2020/065823 priority Critical patent/WO2022132161A1/fr
Publication of WO2022132161A1 publication Critical patent/WO2022132161A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861—Capsules, e.g. for swallowing or implanting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02405—Determining heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6879—Means for maintaining contact with the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0535—Impedance plethysmography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays

Definitions

  • the present disclosure relates to intestinal attachment devices that can be reside in the intestine for at least a temporary period of time.
  • the present disclosure relates to an intestinal attachment device that can reside in the intestine of a patient for at least a day and up to several weeks.
  • the device can be used as an anchoring device for a platform for delivering drugs into the intestine, sensing physiological parameters of the patient, releasing drugs in response to sensed physiological parameters, creating a physical barrier in the intestinal wall, and other applications.
  • an intestinal attachment device comprising an ingestible housing and a substrate contained within the ingestible housing.
  • the substrate can have a top side and a bottom side.
  • a flange can be on bottom side of the substrate and have a tissue facing surface.
  • a suction device can be in communication with the flange or the substrate and a suction port can extend through the tissue facing surface of the flange and be in fluid communication with the suction device.
  • a photoplethysmography (PPG) sensor can be on or extend through the tissue facing surface of the flange and be in proximity to the suction port.
  • a controller can be on the substrate and be configured to receive PPG sensing data from the PPG sensor.
  • FIG. 1 is a top plan view of an intestinal attachment device according to an aspect of the present disclosure.
  • FIG. 2 is a view of the internal components of an intestinal attachment device according to an aspect of the present disclosure.
  • FIG. 3 illustrates an intestinal attachment device at one stage of operation after the device has been swallowed and components of the ingestible housing have been released.
  • FIG. 4 illustrates an intestinal attachment device at another stage of operation after the device has been swallowed and components of the ingestible housing have been released.
  • FIG. 5 is a top view of a printed circuit board with components of an intestinal attachment device.
  • FIG. 6 is a perspective view of the printed circuit board of FIG. 5.
  • FIG. 7 is a graph of PPG data with a PPG sensor directly sutured to the small intestine.
  • FIG. 8 is a graph of oxygen saturation estimation with a PPG sensor directly sutured to the small intestine.
  • FIG. 9 is a graph of PPG data with a PPG sensor loosely clipped to the small intestine with endoclips.
  • FIG. 10 is a graph of oxygen saturation estimation with a PPG sensor loosely clipped to the small intestine.
  • the terms “a,” “an,” and “the” include at least one or more of the described elements including combinations thereof unless otherwise indicated. Further, the terms “or” and “and” refer to “and/or” and combinations thereof unless otherwise indicated.
  • the terms “top” and “bottom” are described with reference to components as illustrated in the figures.
  • an element when referred to as being “on” “attached to,” “mounted on,” “disposed on,” “connected to,” or in “communication with” another element, it can be directly on, attach to, mounted on, disposed on, connected to, or in communication with the other element or intervening elements may also be present unless otherwise indicated.
  • a “patient” as described herein includes a mammal, such as a human being.
  • An “ingestible housing” as used herein is a housing that is not just capable of being ingested but rather is suitable for swallowing and entering into the gastrointestinal tract.
  • a self-contained intestinal attachment device contains an electronic circuit folded into a small capsule or tablet suitable for swallowing.
  • the capsule can pass through the patient’ s stomach and dissolve in the intestine thereby releasing the electronic circuit.
  • the electronic circuit can attach to the mucosal layer of the intestine where it can reside for a temporary period of time, such as up to one week, for example.
  • Sensors within the capsule can monitor one or more physiological parameters of the patient related to a medical condition, such as an opioid overdose, for example.
  • Physiological parameters include electrical cardiac activity, heart rate, heart rate variability, respiratory monitoring (e.g. respiratory rate), saturated oxygen, intestinal tissue color, temperature, bodily motions as detected from the intestine, or combinations thereof.
  • Physiological parameters can be measured by an electrical sensor (e.g. ECG or EMG sensor), an accelerometer (e.g. to sense position or movement including cardiac and respiration movements), a photoplethysograph (PPG) sensor, a temperature sensor, an acoustic sensor (e.g. to monitor cardiac or pulmonary function), a chemical sensor, or suitable combinations thereof.
  • ECG or EMG sensor ECG or EMG sensor
  • accelerometer e.g. to sense position or movement including cardiac and respiration movements
  • PPG photoplethysograph
  • temperature sensor e.g. to monitor cardiac or pulmonary function
  • acoustic sensor e.g. to monitor cardiac or pulmonary function
  • chemical sensor e.g. to monitor cardiac or pulmonary function
  • the ingested device in response to the sensed physiological parameters, can release a therapeutic agent to improve the medical condition.
  • a therapeutic agent for example, in the case of an opioid overdose, upon detecting physiological indications of an opioid overdose, the ingested device can release a rescue medication via a drug dispenser to mitigate the effects of the opioid overdose as well as send out alerts to the patient and/or a caregiver.
  • an intestinal attachment device 10 can comprise an ingestible housing 12 that can contain substrate 14, flange 16, suction device 18, photoplethysmography (PPG) sensor 20, and controller 22.
  • Substrate 14 can have a top side 24 and a bottom side 26 and flange 16 can be coupled to bottom side 26 of substrate 14.
  • Flange 16 can have a tissue facing surface 28 through which suction port 30 extends. The flange mechanically interfaces with the GI tissue and the suction port serves as a conduit or is defined by a tube 38 to provide suction to the space between the flange and the GI tissue.
  • suction port 30 can be in fluid communication with suction device 18.
  • Suction device 18 can be on substrate 14 of device 10.
  • Controller 22 can be on substrate 14 and can be configured to receive PPG sensing data from PPG sensor 20.
  • ingestible housing 12 also contains a drug dispenser 34.
  • the ingestible housing can be a gelatin capsule or can have another type of suitable enteric coating 36 that allows it to pass through the acidic environment of the stomach and then dissolve upon reaching the neutral pH environment of the intestine.
  • the ingestible housing can have any suitable size for swallowing such as between size 000 to size 4.
  • the substrate can assume a folded, furled, compact configuration within the housing and an unfurled configuration when ingested and released from the housing into the patient’s intestine as shown in FIGs. 3 and 4.
  • the substrate can be fabricated from a flexible biodegradable material such as, for example, silk, cellulose, or another biodegradable material.
  • the substrate can be a circuit board, such as a printed circuit board 48 as illustrated in FIGs. 5 and 6.
  • Conductors (not shown) in the substrate can also be fabricated from a biodegradable material, such as, for example, magnesium alloy.
  • the substrate and/or the conductors can be fabricated from a non-biodegradable material.
  • Mechanical links can be integrally formed on the substrate, separating groups of electrical components.
  • the mechanical links can be fabricated of a biodegradable material.
  • the mechanical links can include a biogalvanic material, such that when energized, the mechanical links rapidly corrode.
  • the flange can be flexible or rigid or can have a mechanical compliance therebetween.
  • the flange can be partly stiff and/or partly flexible.
  • the flange can comprise filaments 42 or have filaments extending from the periphery that can help the flange conform to an irregular tissue surface, as the GI wall.
  • the surface of the flange can be textured or have features to engage tissue with an irregular surface.
  • the flange can be flat, cupped, saddle-shaped, have a reverse cup shape, suitable combinations thereof, or other suitable configurations.
  • the outer periphery of the flange can have any suitable shape or configuration, such as round, oval, or another appropriate shape.
  • the flange may also have incorporated therein, tissue adhesives, muco-adhesives or medications.
  • the flange may also include microneedles or microbarbs for medication delivery to assist with adhering to tissue.
  • the material in the flange may be used to conduct light from a circuit to the tissue. Such light may be used for PPG measurements as described in detail below.
  • the device includes a PPG sensor
  • a PPG sensor can detect PPG signals from the intestine and can be used to measure photoplethysmography (PPG), heart-rate monitoring (HRM), and oxygen saturation (SpO2).
  • PPG sensor can be used to extract vital signs such as heart rate and heart rate variability, respiratory rate, and oxygen saturation from the detected PPG signal.
  • PPG is an optical measurement of the volume of an organ. In principle, PPG illuminates the tissue with light of a specific wavelength from a light-emitting diode (LED) to measure organ volume. This light is absorbed, passed through, or reflected back. A photodiode sensor measures the light that is either transmitted or reflected. The light is then converted to an electrical signal.
  • LED light-emitting diode
  • the information can be used to determine a patient’s heart rate.
  • PPG can also provide more information about blood flow and blood pressure. Because PPG can be determined from reflected or transmitted light, only a single point of contact is necessary to measure it. This feature allows for easy, continuous time measurements.
  • the PPG sensor can include a light emitting diode (LED) -photodiode configuration, where the LED(s) is a light emitter and the photodiode (usually p-type, intrinsic, n-type diode (PIN)) is a photodetector (PD).
  • the PPG components such as the PPG LED(s) and the photodiode, can be located on the top side of the substrate or they can be directed through apertures towards the bottom side of the substrate which is where the mucosa of the intestine will be located.
  • the PPG sensor (or other sensor) can be on or extend through the tissue facing surface of the flange.
  • the PPG sensor can be directly mounted on the bottom side of the substrate as illustrated in FIG.
  • the bottom tissue facing surface of the flange or mounted on the top side of the substrate and directed through apertures towards the bottom side of the substrate or the bottom tissue facing surface of the flange.
  • either the PPG sensor LED, or photodiode, or both may be directed towards the tissue through an intervening light pipe or fiber optic.
  • the sensor optically faces the gastrointestinal mucosal wall when the device attaches to the gastrointestinal mucosal wall.
  • tissue is pulled directly against the sensor to ensure stable coupling between the sensor and tissue.
  • suction with an PPG sensor (a) to anchor the device to tissue; and (b) to ensure stable tissue contact between the sensor and tissue which is important to accurately measure physiological data.
  • a problem with using just endoclips as an intestinal fixation device, is that there is still motion between the tissue and the sensor, which generates motion artifact and can interfere with accurate physiological recording.
  • the stable coupling between the tissue and the sensor as described herein ensures that the tissue is pulled still such that there is relative immobilization between the sensor and tissue at the tissue/sensor interface. As such, the sensor does not move independently of the tissue at the sensor/tissue interface, thereby resulting in less motion artifact.
  • a PPG sensor is described herein, other types of sensors could be used where relative motion between the underlying tissue and sensor is minimized in order to obtain an accurate measurement of the sensed data.
  • an imaging sensor could be used with devices as described herein.
  • the PPG sensor or other type of sensor need not be coupled to tissue long term so long as there is a stable interface between the underlying tissue and sensor to minimize motion artifact during recording of the optical data or other type of data.
  • the suction port is defined by a tube 38 having an inlet at one end and an outlet at an opposing end.
  • the inlet can be in communication with the suction device and the PPG sensor can reside within the outlet of the tube.
  • the PPG sensor can be integrated into the suction port which not just anchors the device to the GI mucosal wall but also provides a mechanically stable interface of tissue for optical/physiological sensing.
  • multiple suction ports can be connected to a single suction generation source. Referring to FIGs.
  • an intestinal attachment device 44 can include at least two suction ports 46, one on each side of the PPG sensor 50. With suction ports on both sides of the PPG sensor (left and right), when tissue is pulled by the suction ports, tissue is pulled up tight against the PPG sensor. In other words, tissue is tented over the PPG sensor with suction ports pulling in tissue on both sides.
  • the controller, the PPG sensor, and any additional sensors can be formed at least partially as an application specific integrated circuit. (ASIC).
  • Drug dispenser 34 can be located on either top or bottom surface of the substrate so long as drug can be released from the dispenser and absorbed into the intestines (e.g. delivered into the lumen or delivered into the intestinal wall).
  • suitable drug dispensers include MEMS drug delivery, valve systems, iontophoretic systems, osmotic plug pistons, electrolytical pumps, microneedles, or combinations thereof.
  • One or several components of the intestinal attachment device can establish contact with the gastrointestinal tissue in the same location within the GI tract or different locations within the same GI tract with a flexible connection between the multiple components.
  • an anchor and the sensor of the device adhere to the intestinal wall while other components of the device are not attached to the intestinal wall (e.g. “float”).
  • the substrate and flange can unfurl and only the sensing portion of the device (e.g. the PPG sensor), any additional anchors, and the flange can attach to the gastrointestinal wall and the remaining portions/modules of the device (e.g. the substrate and other components disposed on or otherwise mechanically linked to the substrate) do not adhere to the gastrointestinal wall and “float” downstream as a multi-module chain linked together.
  • the suction device can be on the top side of the substrate and the suction port can extend through the substrate and the flange of the device.
  • the suction device can be a mechanical, electrical, and/or chemical device to provide suction.
  • the suction device can be an electrical and/or chemical pump to provide suction in order to adhere the device to the intestinal wall.
  • the suction be actively controlled and repeatedly applied either at fixed intervals or responsively due to pressure changes.
  • a mechanical force can provide suction.
  • the mechanical force can be used to press the device against the tissue of the GI tract, thereby generating suction and reducing the volume between the device and the tissue.
  • the mechanical force can be transiently provided by a material that swells to push the flange against the intestinal wall causing attachment.
  • the material can exist long enough to allow the suction to cause the device to adhere to the intestinal wall and then can dissolve.
  • a stent, balloon, or other spring-like device can be used to provide force to generate enough suction to attach the device to the intestinal wall.
  • the device can also have a memory, a battery (or other energy delivery device such as a super capacitor or fuel cell) to power the device, and a communication module such as a non-specific radio module or other wireless communication module.
  • the wireless communication module can communicate with an external device to send alerts to a caregiver or a clinician as well as receive instructions from an external device.
  • the ingested device can include a Bluetooth radio that can communicate directly with a smart phone or other Bluetooth enabled device outside the patient’s body.
  • the Bluetooth radio can be a 2.4 GHz Bluetooth or a BLE (Bluetooth Low Energy) radio.
  • the communication link can allow a physician clinician to configure the intestinal attachment device to collect certain data and to retrieve the data after it has been collected.
  • wireless data telemetry can be achieved using a sub-GHz frequency radio (specifically 400 - 900 MHz, including 433 MHz radios) communicating to a small receiver, such as a key fobsized receiver, that can be carried by the patient or otherwise placed on the patient’ s person that mediates data transfer between the intestinal attachment device and a smartphone via Bluetooth.
  • a sub-GHz frequency radio specifically 400 - 900 MHz, including 433 MHz radios
  • a small receiver such as a key fobsized receiver
  • FIGs. 3 and 4 are side views of intestinal attachment device 10 where the coating has dissolved and substrate 14 is in an unfurled configuration (FIGs. 3 and 4 exclude drug dispenser 34 of FIG. 2 for purposes of clarity).
  • device 10 comprises a PPG sensor 20 but the device can contain other/additional sensing components, such as an accelerometer and sensing electrodes that can be used for ECG monitoring and/or for impedance plethysmography (IPG), for example.
  • the sensor(s) detect at least one physiological parameter indicative of an opioid overdose.
  • FIG. 3 and 4 illustrate device 10 at two different stages of operation after the device has been swallowed, the enteric coating of the ingestible housing has dissolved, and substrate 14 and flange 16 (and accompanying components) have unfurled.
  • FIG. 3 illustrates flange 16 next to GI tissue 40.
  • Flange 16 is positioned sufficiently close to tissue 40 to effectively create a seal between the tissue and the flange.
  • flange 16 Prior to adhering to tissue 40, flange 16, which can be a soft silicone rubber flange, can have a slightly cupped configuration.
  • At the perimeter of flange 16 can be an edge that includes filaments to assist the flange in conforming to the irregular surface of the tissue 40.
  • Suction device 18 which can communicate with tube 38, can be activated to apply suction to the region between flange 16 and tissue 40.
  • FIG. 4 illustrates flange 16 adhering to tissue 40. The adhesion is accomplished by suction device 18 lowering the pressure in the space between flange 16 and tissue 40 by drawing air or fluid through tube 38.
  • the suction device may operate in a number of different ways.
  • the suction device can contain a pre-packaged volume containing a low or near vacuum level of pressure. Opening a valve to the tube would cause the required decrease in pressure in the space between the flange and the tissue.
  • Other mechanisms including electrically or chemically driven pumps could also be used.
  • the suction device may be mounted as shown on a common circuit board or may be physically remove and connected to the tube by an additional piece of tubing.
  • Intestinal attachment devices can also include fasteners to keep the device attached to tissue on a more long-term basis. Suction can be a temporary method to get tissue into a suction well. Intestinal attachment devices can include fasteners such as microneedles, pins, or staples, for example, can penetrate/grab tissue to hold the device in place against the tissue.
  • FIGs. 7-10 are graphs of PPG data quality with and without tight anchoring to tissue
  • FIGs. 7 and 8 are graphs of PPG data and oxygen saturation estimation, respectively, with a PPG sensor directly sutured to the small intestine. Cardiac waves are visible and oxygen saturation estimates are accurate. Oxygen saturation measured by lab vitals equipment was 95-97%.
  • FIGs. 9 and 10 are graphs of PPG data and oxygen saturation estimation with a PPG sensor loosely clipped to the small intestine with endoclips. Cardiac waves are not visible and estimated oxygen saturation is not accurate. Oxygen saturation measured by lab vitals equipment was 90 - 95%.

Abstract

L'invention concerne un dispositif d'attache intestinale qui comprend un boîtier ingérable et un substrat contenu à l'intérieur du boîtier ingérable. Une bride se trouve sur le substrat et comprend une surface faisant face au tissu. Un dispositif d'aspiration se trouve sur la bride ou le dispositif d'aspiration, et un orifice d'aspiration s'étend à travers la surface faisant face au tissu de la bride et est en communication fluidique avec le dispositif d'aspiration. Un capteur de photopléthysmographie (PPG) se trouve sur ou s'étend à travers la surface faisant face au tissu de la bride et est à proximité de l'orifice d'aspiration. Un contrôleur se trouve sur le substrat et est configuré pour recevoir des données de détection de PPG provenant du capteur de PPG.
PCT/US2020/065823 2020-12-18 2020-12-18 Dispositif d'attache intestinale WO2022132161A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2020/065823 WO2022132161A1 (fr) 2020-12-18 2020-12-18 Dispositif d'attache intestinale

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2020/065823 WO2022132161A1 (fr) 2020-12-18 2020-12-18 Dispositif d'attache intestinale

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WO2022132161A1 true WO2022132161A1 (fr) 2022-06-23

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120165795A1 (en) * 2010-12-28 2012-06-28 Medtronic, Inc. Therapeutic agent reservoir delivery system
US20130276785A1 (en) * 2010-08-17 2013-10-24 Richard J. Melker Central Site Photoplethysmography, Medication Administration, And Safety
US20180164221A1 (en) * 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US10325951B2 (en) * 2008-10-07 2019-06-18 Mc10, Inc. Methods and applications of non-planar imaging arrays

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10325951B2 (en) * 2008-10-07 2019-06-18 Mc10, Inc. Methods and applications of non-planar imaging arrays
US20130276785A1 (en) * 2010-08-17 2013-10-24 Richard J. Melker Central Site Photoplethysmography, Medication Administration, And Safety
US20120165795A1 (en) * 2010-12-28 2012-06-28 Medtronic, Inc. Therapeutic agent reservoir delivery system
US20180164221A1 (en) * 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems

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