WO2022122656A1

WO2022122656A1 - Micro fluidic valve block

Info

Publication number: WO2022122656A1
Application number: PCT/EP2021/084405
Authority: WO
Inventors: Eldon GODDARD; Dickson Ong
Original assignee: Norgren Kloehn Llc
Priority date: 2020-12-09
Filing date: 2021-12-06
Publication date: 2022-06-16

Abstract

A micro fluidic valve block includes a first distribution valve; a second distribution valve; and a manifold. The first distribution valve and the second distribution valve are arranged to face one another, with the manifold arranged therebetween. The manifold provides a common fluid flow path between the first distribution valve and the second distribution valve. The first distribution valve and the second distribution valve are each driven by an independent rotational drive mechanism, so as to allow for independent port selection.

Description

Micro Fluidic Valve Block

TECHNICAL FIELD

[0001] The present disclosure relates to a micro fluidic valve block. Particularly, but not exclusively, the disclosure relates to a micro fluidic valve block incorporating two or more distribution valves. Aspects of the disclosure relate to a micro fluidic valve block and to a method of assembling a micro fluidic valve block.

BACKGROUND

[0002] There are a number of micro fluidic system arrangements, which provide precise and controlled metering of small quantities of fluids. Such fluidic systems use a pair of rotary valves connected by tubing. The pair of rotary valves includes a single valve that is connected to another single valve with tubing between a common port. Such an arrangement may have a relatively large internal volume. This is because the connecting tubing itself contributes to the internal volume.

[0003] Other fluidic systems use a manifold with a pair of solenoid valves. Again, such an arrangement may have a relatively large internal volume. This is because of the fundamental design of the media separation of each solenoid valve. Solenoid valves are generally designed with a larger cavity and a common diaphragm that, when actuated, seals over each port of the valve.

[0004] Micro-fluidic analytical processes also involve small sample sizes. As used herein, sample volumes considered to involve micro- fluidic techniques can range from as low as volumes of only several picoliters or so, up to volumes of several milliliters (mL) or so. Micro-fluidic techniques can also be expressed as those involving fluid flow rates of about 0.5 mL/minute or less. It is with respect to these and other considerations that the disclosure made herein is presented. SUMMARY

[0005] The present disclosure describes implementations that relate to a micro fluidic valve block.

[0006] In a first example implementation, the present disclosure describes a micro fluidic valve block. The micro fluidic valve block includes: a first distribution valve; a second distribution valve; and a manifold, wherein the first distribution valve and the second distribution valve are arranged to face one another, with the manifold arranged therebetween, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve, and wherein the first distribution valve is driven by a first rotational drive mechanism and the second distribution valve is driven by a second rotational drive mechanism, which is independent of the first rotational drive mechanism, so as to allow for independent port selection.

[0007] In a second example implementation, the present disclosure describes a method of assembling a micro fluidic valve block. The method includes: providing micro fluidic valve block comprising a first distribution valve, a second distribution valve, and a manifold; arranging the manifold between the first distribution valve and second distribution valve, such that the first distribution valve and the second distribution valve are arranged to face one another, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve; and assembling a first rotational drive mechanism to the first distribution valve and a second rotational drive mechanism to the second distribution valve, wherein the second rotational drive mechanism is independent of the first rotational drive mechanism so as to allow for independent port selection.

[0008] The foregoing summary is illustrative only and is not intended to be in any way limiting. In addition to the illustrative aspects, implementations, and features described above, further aspects, implementations, and features will become apparent by reference to the figures and the following detailed description.

BRIEF DESCRIPTION OF THE FIGURES

[0009] The novel features believed characteristic of the illustrative examples are set forth in the appended claims. The illustrative examples, however, as well as a preferred mode of use, further objectives and descriptions thereof, will best be understood by reference to the following detailed description of an illustrative example of the present disclosure when read in conjunction with the accompanying Figures.

[0010] Figure 1 illustrates a side elevation view of a micro fluidic valve block, in accordance with an example implementation.

[0011] Figure 2 illustrates an exploded side view elevation of the micro fluidic valve block of Figure 1, in accordance with an example implementation.

[0012] Figure 3 illustrates a plan view of a manifold of the micro fluidic valve block of Figure 1, in accordance with an example implementation.

[0013] Figure 4 illustrates an enlarged cut-away view along line A-A shown in Figure 3, in accordance with an example implementation.

[0014] Figure 5 illustrates a fluidic system diagram, in accordance with an example implementation.

[0015] Figure 6 is a flowchart of a method of assembling a micro fluidic valve block, in accordance with an example implementation. DETAILED DESCRIPTION

[0016] The present disclosure describes systems and methods associated with a micro fluidic valve block.

[0017] According to an aspect of the disclosure, there is provided a micro fluidic valve block comprising: a first distribution valve; a second distribution valve; and a manifold, wherein the first distribution valve and the second distribution valve are arranged to face one another, with the manifold arranged therebetween, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve, and wherein the first valve and the second valve are each driven by an independent rotational drive mechanism, so as to allow for independent port selection.

[0018] The micro fluidic valve block of the present disclosure incorporates two distribution valves connected by a common connection to a manifold that has an internal common fluid path. Each distribution valve is driven by a respective rotational drive mechanism that allows for independent port selection. By incorporating the two distribution valves into a single assembly, a reduction in internal volume is accomplished. Solenoid valves require a manifold to create a common flow path whereas with the disclosed dual distribution valve configuration, the “manifold” is communized into what used to be a stator, which allows for small fluid paths, and therefore smaller internal volumes.

[0019] Thus, the micro fluidic valve block of the present disclosure eliminates the tubing between the distribution valves. The disclosed configuration of the micro fluidic valve block may thus reduce the internal volume. Furthermore, the number of possible leak points is reduced. The disclosed dual distribution valve configuration eliminates the requirement for tubing that would be required in an equivalent design using two rotary valves. Similarly, the disclosed configuration reduces the number of potential leak points. For example, threaded ports, as used on rotary valves, give rise to additional potential leak points.

[0020] A first rotational drive mechanism of the first distribution valve may have a first rotational drive mechanism axis. A second rotational drive mechanism of the second distribution valve may have a second rotational drive mechanism axis. In an example, the first and second axes may be concentric. Alternatively, in another example, the first rotational drive mechanism may have a first rotational drive mechanism axis and the second rotational drive mechanism may have a second rotational drive mechanism axis, and the second rotational drive mechanism axis may be radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm, as an example. In one example, each independent rotational drive mechanism may be a stepper motor.

[0021] The rotational drive mechanism of the first distribution valve may have an axis, which is concentric with a respective axis of the first distribution valve. The rotational drive mechanism of the second distribution valve may have an axis, which is concentric with a respective axis of the second distribution valve.

[0022] The manifold may have at least a first chamber to receive the first distribution valve and a second chamber to receive the second distribution valve, the first and second chambers being fluidly connected via the common fluid flow path. The manifold may further have at least a first port and a second port, wherein the first port and the second port are in fluid communication with the first chamber and the second chamber of the manifold, respectively.

[0023] The first distribution valve may have a plurality of ports and the second distribution valve may have a respective plurality of ports. The number of ports of the first distribution valve can be similar or different from a respective number of ports of the second distribution valve. In one example, the number of ports in the first distribution valve may be between 2 and 24. [0024] At least one of the first distribution valve and the second distribution valve may have a valve plug. The valve plug has a fluid channel having a radial section that extends co-axially with a fluid channel of a respective port fitting. The valve plug may facilitate allowing communication from one port of a respective distribution valve while sealing other ports thereof via a radial sealing configuration. As such, the first distribution valve may be referred to as a plug sealing valve. The second distribution valve may also have a respective valve plug, and may thus be referred to as a plug sealing valve. In other example implementation, rather than using a radial sealing configuration, the first distribution valve may be a face sealing valve where a face seal configuration is used.

[0025] The first distribution valve may have a location feedback device. The second distribution valve may have a location feedback device.

[0026] According to another aspect of the disclosure, there is provided a method of assembling a micro fluidic valve block. The method comprises: providing micro fluidic valve block comprising a first distribution valve, a second distribution valve, and a manifold; arranging the manifold between the first distribution valve and second distribution valve, such that the first distribution valve and the second distribution valve are arranged to face one another, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve; and assembling an independent rotational drive mechanism to each of the first distribution valve and the second distribution valve so as to allow for independent port selection.

[0027] The method may further comprise aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that the first and second axes are concentric. [0028] The method may further comprise aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

[0029] The method may further comprise setting a valve zero position (e.g., an initial position of home position) in the rotary feedback device by inserting a pin in a radial section of a fluid channel of the first distribution valve, and programing the rotary feedback device accordingly. The rotary feedback device may be an encoder.

[0030] The ports of the distribution valves may be aligned directly to a home position of the rotary feedback device during assembly. In conventional valve products, alignment of the valve port to the electronics has been done by tolerancing the part so that when assembled the ports are relatively close to the expected position. In the present disclosure, it is possible to insert a pin into the port to lock the rotating mechanism in position while the rotary feedback device position relative to the hardware is programed. This ensures that the port alignment is maintained.

[0031] Advantageously, installation orientation is no longer a concern because, for example, during the assembly process, a port of a respective distribution valve is located with respect to a rotor (of a respective rotary drive mechanism) using a pin before programming the home position of the rotary feedback device. Additionally, this may alleviate the risk of port occlusion as the rotor position would be programmed to an almost exact position and eliminates tolerance stack up normally incurred in an assembly.

[0032] Referring now to the Figures, Figure 1 illustrates a side elevation view of a micro fluidic valve block 10, and Figure 2 illustrates an exploded side elevation of the micro fluidic valve block

10, in accordance with an example implementation. As shown in Figures 1 and 2, the micro fluidic valve block 10 comprises a first distribution valve 20, a second distribution valve 30, and a manifold 40. The first distribution valve 20 and the second distribution valve 30 are arranged to face one another, with the manifold 40 arranged or interposed therebetween.

[0033] The first distribution valve 20 has a first distribution valve motor 22. The second distribution valve 30 has a second distribution valve motor 32. In the example implementation of Figures 1-2, the first distribution valve motor 22 and the second distribution valve motor 32 are stepper motors. In an alternate implementation, the first distribution valve motor 22 and second distribution valve motor 32 can be other rotational drive mechanisms, comprising any of a manual lever, a manual knob, a DC motor, an AC motor, or a piezo motor.

[0034] The first distribution valve motor 22, or first rotational drive mechanism has a first rotational drive mechanism axis. The second distribution valve motor 32, or second rotational drive mechanism has a second rotational drive mechanism axis.

[0035] In a first example, the first rotational drive mechanism axis and the second rotational drive mechanism axis are concentric. In another example, the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

[0036] The first distribution valve motor 22 has electrical connections 24 and the second distribution valve motor 32 has electrical connections 34 to provide electrical power and control to the distribution valve motors 22, 32, respectively. Further, the first distribution valve motor 22 has motor valve shaft 26 and the second distribution valve motor 32 has motor valve shaft 36 to provide rotational motion as explained in more detail below. [0037] In the example implementation of Figures 1-2, the first distribution valve 20 and the second distribution valve 30 are substantially similar. The first distribution valve 20 has a coil spring 52, a thrust bearing 54, a valve blade 56, a valve plug collar 58, and a valve plug 60.

[0038] The coil spring 52, the thrust bearing 54, the valve blade 56, the valve plug collar 58, and the valve plug 60 of the first distribution valve 20 are arranged on or about a first distribution valve axis. Similarly, a coil spring 53, a thrust bearing 55, a valve blade 57, a valve plug collar 59 and a valve plug 61 of the second distribution valve 30 are arranged on or about a second distribution valve axis.

[0039] In the example implementation in Figures 1-2, the first rotational drive mechanism axis is concentric with the first distribution valve axis, and the second rotational drive mechanism axis is concentric with the second distribution valve axis.

[0040] The manifold 40 includes a housing 41. The manifold 40 also includes a first flange 42 and a second flange 44 coupled to the housing 41. The first flange 42 is fastened to the first distribution valve motor 22 by fasteners 70. The second flange 44 is fastened to the second distribution valve motor 32 by fasteners 72. Thus, when assembled, the first distribution valve 20 and the second distribution valve 30 are arranged to face one another, with the manifold 40 arranged or interposed therebetween. Further, screws 62 mount the first flange 42 and the second flange 44 to the housing 41 of the manifold 40.

[0041] Figure 3 illustrates a plan view of the manifold 40 of the micro fluidic valve block 10, and Figure 4 illustrates an enlarged cut-away view of the manifold 40 along line A- A shown in Figure 3, in accordance with an example implementation. Figures 3 and 4 illustrate the manifold 40 in more detail. The manifold 40 has a first chamber 80 and a second chamber 82. The first chamber 80 receives the coil spring 52, the thrust bearing 54, the valve blade 56, the valve plug collar 58 and the valve plug 60 of the first distribution valve 20. The second chamber 82 receives the coil spring 53, the thrust bearing 55, the valve blade 57, the valve plug collar 59, and the valve plug 61 of the second distribution valve 30.

[0042] In an example, each of the valve plugs 60, 61 fits within the respective chamber (i.e., the first chamber 80 and the second chamber 82, respectively) with a fluid tight seal. This way, the valve plugs 60, 61 facilitate radial sealing (about the circumference of the valve plugs 60, 61). As such, the first distribution valve 20 and the second distribution valve 30 can be referred to as plug sealing valves.

[0043] The manifold 40 has a first valve port plane (e.g., the first valve port plane 104 shown in Figure 5) and a second valve port plane (e.g., the second valve port plane 102 shown in Figure 5). Referring to Figures 2 and 4, the first valve port plane include two radially- extending ports, a first port 90a, and a second port 90b. Looking end on to the manifold 40 as per Figure 3, the first port 90a extends radially at approximately 45° from the vertical, whilst the second port 90b extends radially at approximately 150° from the vertical.

[0044] The second valve port plane includes nine radially-extending ports, a first port 92a, a second port 92b, a third port 92c, a fourth port 92d, a fifth port 92e, a sixth port 92f, a seventh port 92g, an eighth port 92h, and a ninth port 92i. The nine radially-extending ports are distributed evenly (i.e., equi-angled or equi-spaced) about the circumference of the second valve port plane.

[0045] The ports of the first and second valve port planes are similar in construction, such that only one of each shall be described in detail. As best shown in Figure 4, the first port 90a of the first valve port plane has a first port fitting 94. The ninth port 92i of the second valve port plane has a ninth port fitting 96. The first port fitting 94 has a fluid channel 98 therein. Similarly, the ninth port fitting 96 has a fluid channel 99 therein. The fluid channels 98, 99 are configured to be selectively in fluid communication with the first chamber 80 and the second chamber 82 of the manifold 40 based on rotational position of the respective valve plug of the valve plugs 60, 61.

[0046] Particularly, the valve plug 60 has a fluid channel, which can selectively fluidly link or couple the fluid channel 98 of the respective port of the ports 90a-90b to a central fluid channel 46 provided in the housing 41 of the manifold 40. The fluid channel within the valve plug 60 has (i) a radial section 66 that extends co-axially with the fluid channel 98 of the port fitting 94, when the two are aligned, and (ii) an axial section 68, which extends axially along the valve plug 60 and perpendicularly with respect to the radial section 66. The axial section 68 is co-axial with the central fluid channel 46 of the housing 41 of the manifold 40. The valve plug 61 has a respective fluid channel with a similar arrangement having a radial section that extends co-axially with the fluid channel 99 of the port fitting 96, when the two are aligned, and an axial section, which extends axially along the valve plug 61 and perpendicularly with respect to the radial section. The axial section is co-axial with the central fluid channel 46 of the housing 41 of the manifold 40.

[0047] The motor valve shaft 26 (shown in Figure 2) engages the valve blade 56 to turn the valve plug 60 rotationally. This allows selective fluid communication between the central fluid channel 46 of the manifold 40 and the fluid channel 98 of the applicable port of the ports 90a-90b, while sealing or blocking the other port. Similarly, the motor valve shaft 36 (shown in Figure 2) engages the valve blade 57 to turn the valve plug 61 rotationally. This allows selective fluid communication between the central fluid channel 46 of the manifold 40 and the fluid channel 99 of the applicable port of the ports 92a- 92i, while sealing or blocking the other ports. As such, the rotational position of the valve plug 60 and the valve plug 61 determines which port of the ports 90a-90b is in fluid communication with which port of the ports 92a- 92i. [0048] The use of the fluid channels (e.g., the central fluid channel 46, the radial section 66, the axial section 68, and the fluid channel 98) within the manifold 40, the valve plugs 60, and port fittings such as the port fitting 94 (and the respective fluid channels of the valve plug 61, and port fitting such as the port fitting 96) significantly reduces the internal volume of the micro fluidic valve block 10. In an example implementation of the present disclosure, the internal volume is approximately 10 - 15 microliter (uL) including the two distribution valves 20, 30 (e.g., plug sealing or face sealing) and the manifold 40. An equivalent pair of rotary valves with connecting tubing, according to a conventional implementation, would have an internal volume of approximately 100- 300 uL. Similarly, using conventional solenoid valves would result in an internal volume of approximately 900 uL.

[0049] The number of ports on each side of the manifold 40 may be varied. In the example implementation shown in the Figures, two ports are provided on the left side of the manifold 40 (i.e., the ports 90a-90b), whilst nine ports (i.e., the ports 92a- 92i) are provided on the right side of the manifold 40. However, the number of ports is only limited by the size of the manifold 40. For example, 24 or more ports could be provided on either side of the manifold 40. This results in a large number of possible combinations.

[0050] Figure 5 illustrates an example system fluidic diagram, in accordance with an example implementation. A circle represents the second valve port plane 102 and is shown with nine separate fluid sources connected to the nine ports 92a-92i: a first fluid source 102a, a second fluid source 102b, a third fluid source 102c, a fourth fluid source 102d, a fifth fluid source 102e, a sixth fluid source port 102f, a seventh fluid source 102g, an eighth fluid source 102h, and a ninth fluid source 102i. [0051] Figure 5 depicts another circle that represents the first valve port plane 104. The first valve port plane 104 is shown with two separate onward fluid connections, representing the first port 90a, and the second port 90b.

[0052] The micro fluidic valve block 10 is thus able to provide fluid from any of nine fluid sources (the fluid sources 102a-102i) via two separate fluid connections (to the first port 90a or the second port 90b).

[0053] The materials of the valve can be changed to suit different chemical compatibility or life issues of the customer.

[0054] The type of valve can be changed and still accomplish the results. For example, a face sealing valve configuration can be used instead of the valve plugs 60, 61, which radially seal the valves. A combination of plug/plug, face/face, or plug/face could be used.

[0055] Referring back to Figure 4, during assembly and set up of the micro fluidic valve block 10, the radial section 66 of the fluid channel of the valve plug 60 may be used to determine a valve zero position (i.e., a home position or an initial position). By inserting a pin or similar device in the radial section 66, and programing a rotary feedback device accordingly, the zero position or home position may be set.

[0056] In an example, the rotary feedback device is an encoder. Alternatively, in another example, the rotary feedback device is a resolver. In still another example, the rotary feedback device is a light wheel.

[0057] Figure 6 is a flowchart of a method 600 of assembling the micro fluidic valve block 10, in accordance with an example implementation. The method 600 may include one or more operations, or actions as illustrated by one or more of blocks 602, 604, and 606. Although the blocks are illustrated in a sequential order, these blocks may also be performed in parallel, and/or in a different order than those described herein. Also, the various blocks may be combined into fewer blocks, divided into additional blocks, and/or removed based upon the desired implementation. It should be understood that for this and other processes and methods disclosed herein, flowcharts show functionality and operation of one possible implementation of present examples. Alternative implementations are included within the scope of the examples of the present disclosure in which functions may be executed out of order from that shown or discussed, including substantially concurrent or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art

[0058] At block 602, the method 600 includes providing the micro fluidic valve block 10 comprising the first distribution valve 20, the second distribution valve 30, and the manifold 40. The term “providing” as used herein, and for example with regard to the micro fluidic valve block 10 or other components includes any action to make the micro fluidic valve block 10 or any other component available for use, such as supplying components of the micro fluidic valve block 10 or bringing components of the micro fluidic valve block 10 to an apparatus or to a work environment for further processing (e.g., mounting other components, etc.).

[0059] At block 604, the method 600 includes arranging the manifold 40 between the first distribution valve 20 and second distribution valve 30, such that the first distribution valve 20 and the second distribution valve 30 are arranged to face one another, wherein the manifold 40 provides a common fluid flow path (e.g., the fluid path comprising the central fluid channel 46) between the first distribution valve 20 and the second distribution valve 30.

[0060] At block 606, the method 600 includes assembling a first rotational drive mechanism (e.g., the first distribution valve motor 22) to the first distribution valve 20 and a second rotational drive mechanism (e.g., the second distribution valve motor 32) to the second distribution valve 30, wherein the second rotational drive mechanism is independent of the first rotational drive mechanism so as to allow for independent port selection.

[0061] The method 600 can include further steps. For example, the method 600 includes aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that the first and second axes are concentric. In another example, the method 600 includes aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

[0062] As described above, each of the distribution valves 20, 30 can include a rotary feedback device. The method 600 can further include setting a valve zero position in a rotary feedback device of the first distribution valve by inserting a pin in a radial section of a fluid channel disposed in first distribution valve, and programing a rotary feedback device accordingly.

[0063] The detailed description above describes various features and operations of the disclosed systems with reference to the accompanying figures. The illustrative implementations described herein are not meant to be limiting. Certain aspects of the disclosed systems can be arranged and combined in a wide variety of different configurations, all of which are contemplated herein.

[0064] Further, unless context suggests otherwise, the features illustrated in each of the figures may be used in combination with one another. Thus, the figures should be generally viewed as component aspects of one or more overall implementations, with the understanding that not all illustrated features are necessary for each implementation. [0065] Additionally, any enumeration of elements, blocks, or steps in this specification or the claims is for purposes of clarity. Thus, such enumeration should not be interpreted to require or imply that these elements, blocks, or steps adhere to a particular arrangement or are carried out in a particular order.

[0066] Further, devices or systems may be used or configured to perform functions presented in the figures. In some instances, components of the devices and/or systems may be configured to perform the functions such that the components are actually configured and structured (with hardware and/or software) to enable such performance. In other examples, components of the devices and/or systems may be arranged to be adapted to, capable of, or suited for performing the functions, such as when operated in a specific manner.

[0067] By the term “substantially,” “about,” or “approximately” it is meant that the recited characteristic, parameter, or value need not be achieved exactly, but that deviations or variations, including for example, tolerances, measurement error, measurement accuracy limitations and other factors known to skill in the art, may occur in amounts that do not preclude the effect the characteristic was intended to provide.

[0068] The arrangements described herein are for purposes of example only. As such, those skilled in the art will appreciate that other arrangements and other elements (e.g., machines, interfaces, operations, orders, and groupings of operations, etc.) can be used instead, and some elements may be omitted altogether according to the desired results. Further, many of the elements that are described are functional entities that may be implemented as discrete or distributed components or in conjunction with other components, in any suitable combination and location.

[0069] While various aspects and implementations have been disclosed herein, other aspects and implementations will be apparent to those skilled in the art. The various aspects and implementations disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope being indicated by the following claims, along with the full scope of equivalents to which such claims are entitled. Also, the terminology used herein is for the purpose of describing particular implementations only, and is not intended to be limiting.

[0070] Embodiments of the present disclosure can thus relate to one of the enumerated example embodiment (EEEs) listed below.

[0071] EEE 1 is a micro fluidic valve block comprising: a first distribution valve; a second distribution valve; and a manifold, wherein the first distribution valve and the second distribution valve are arranged to face one another, with the manifold arranged therebetween, and wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve, and wherein the first distribution valve is driven by a first rotational drive mechanism and the second distribution valve is driven by a second rotational drive mechanism, which is independent of the first rotational drive mechanism, so as to allow for independent port selection.

[0072] EEE 2 is the micro fluidic valve block of EEE 1, wherein the first rotational drive mechanism has a first rotational drive mechanism axis and the second rotational drive mechanism has a second rotational drive mechanism axis, and the first rotational drive mechanism axis and second rotational drive mechanism axis are concentric.

[0073] EEE 3 is the micro fluidic valve block of any of EEEs 1 -2, wherein the first rotational drive mechanism has a first rotational drive mechanism axis and the second rotational drive mechanism has a second rotational drive mechanism axis, and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm. [0074] EEE 4 is the micro fluidic valve block of any of EEEs 1-3, wherein the first rotational drive mechanism has an axis, which is concentric with a first distribution valve axis.

[0075] EEE 5 is the micro fluidic valve block of any of EEEs 1-4, wherein the second rotational drive mechanism has an axis, which is concentric with a second distribution valve axis.

[0076] EEE 6 is the micro fluidic valve block of any of EEEs 1-5, wherein the manifold has at least a first chamber to receive the first distribution valve and a second chamber to receive the second distribution valve, the first and second chambers being fluidly connected via the common fluid flow path.

[0077] EEE 7 is the micro fluidic valve block of EEE 6, wherein the manifold has at least a first port and a second port, wherein the first port and the second port are in fluid communication with a respective chamber of the first chamber and the second chamber of the manifold.

[0078] EEE 8 is the micro fluidic valve block of any of EEEs 1-7, wherein the first distribution valve is a plug sealing valve.

[0079] EEE 9 is the micro fluidic valve block of any of EEEs 1-8, wherein the second distribution valve is a plug sealing valve.

[0080] EEE 10 is the micro fluidic valve block of any of EEEs 1 -9, wherein the first distribution valve is a face sealing valve.

[0081] EEE 11 is the micro fluidic valve block of any of EEEs 1-10, wherein each independent rotational drive mechanism is a stepper motor.

[0082] EEE 12 is the micro fluidic valve block of any of EEEs 1-11, wherein a number of ports in the first distribution valve is between 2 and 24. [0083] EEE 13 is the micro fluidic valve block of any of EEEs 1-12, wherein at least one of the first distribution valve and the second distribution valve has a valve plug, wherein the valve plug has a fluid channel having a radial section that extends co-axially with a fluid channel of a respective port fitting.

[0084] EEE 14 is the micro fluidic valve block of any of EEEs 1-13, wherein the first distribution valve has a location feedback device.

[0085] EEE 15 is the micro fluidic valve block of any of EEEs 1-14, wherein the second distribution valve has a location feedback device.

[0086] EEE 16 is a method of assembling a micro fluidic valve block, the method comprising: providing micro fluidic valve block comprising a first distribution valve, a second distribution valve, and a manifold; arranging the manifold between the first distribution valve and second distribution valve, such that the first distribution valve and the second distribution valve are arranged to face one another, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve; and assembling a first rotational drive mechanism to the first distribution valve and a second rotational drive mechanism to the second distribution valve, wherein the second rotational drive mechanism is independent of the first rotational drive mechanism so as to allow for independent port selection.

[0087] EEE 17 is the method of EEE 16, further comprising: aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that the first rotational drive mechanism axis and the second rotational drive mechanism axis are concentric. [0088] EEE 18 is the method of any of EEEs 16-17, further comprising: aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

[0089] EEE 19 is the method of EEE 18, wherein the first distribution valve comprises a rotary feedback device, and wherein the method further comprises: setting a valve zero position in the rotary feedback device by inserting a pin in a, radial section of a fluid channel disposed in first distribution valve, and programing the rotary feedback device accordingly.

[0090] EEE 20 is the method of EEE 19, wherein the rotary feedback device is an encoder.

Claims

CLAIMS What is claimed is:

1. A micro fluidic valve block comprising: a first distribution valve; a second distribution valve; and a manifold, wherein the first distribution valve and the second distribution valve are arranged to face one another, with the manifold arranged therebetween, and wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve, and wherein the first distribution valve is driven by a first rotational drive mechanism and the second distribution valve is driven by a second rotational drive mechanism, which is independent of the first rotational drive mechanism, so as to allow for independent port selection.

2. The micro fluidic valve block of claim 1, wherein the first rotational drive mechanism has a first rotational drive mechanism axis and the second rotational drive mechanism has a second rotational drive mechanism axis, and the first rotational drive mechanism axis and second rotational drive mechanism axis are concentric.

3. The micro fluidic valve block of claim 1, wherein the first rotational drive mechanism has a first rotational drive mechanism axis and the second rotational drive mechanism has a second rotational drive mechanism axis, and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

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4. The micro fluidic valve block of claim 1, wherein the first rotational drive mechanism has an axis, which is concentric with a first distribution valve axis.

5. The micro fluidic valve block of claim 1, wherein the second rotational drive mechanism has an axis, which is concentric with a second distribution valve axis.

6. The micro fluidic valve block of claim 1, wherein the manifold has at least a first chamber to receive the first distribution valve and a second chamber to receive the second distribution valve, the first and second chambers being fluidly connected via the common fluid flow path.

7. The micro fluidic valve block of claim 6, wherein the manifold has at least a first port and a second port, wherein the first port and the second port are in fluid communication with a respective chamber of the first chamber and the second chamber of the manifold.

8. The micro fluidic valve block of claim 1, wherein the first distribution valve is a plug sealing valve.

9. The micro fluidic valve block of claim 1, wherein the second distribution valve is a plug sealing valve.

10. The micro fluidic valve block of claim 1, wherein the first distribution valve is a face sealing valve.

11. The micro fluidic valve block of claim 1 , wherein each independent rotational drive mechanism is a stepper motor.

12. The micro fluidic valve block of claim 1, wherein a number of ports in the first distribution valve is between 2 and 24.

13. The micro fluidic valve block of claim 1 , wherein at least one of the first distribution valve and the second distribution valve has a valve plug, wherein the valve plug has a fluid channel having a radial section that extends co-axially with a fluid channel of a respective port fitting.

14. The micro fluidic valve block of claim 1, wherein the first distribution valve has a location feedback device.

15. The micro fluidic valve block of claim 1 , wherein the second distribution valve has a location feedback device.

16. A method of assembling a micro fluidic valve block, the method comprising: providing micro fluidic valve block comprising a first distribution valve, a second distribution valve, and a manifold; arranging the manifold between the first distribution valve and second distribution valve, such that the first distribution valve and the second distribution valve are arranged to face one another, wherein the manifold provides a common fluid flow path between the first distribution valve and the second distribution valve; and assembling a first rotational drive mechanism to the first distribution valve and a second rotational drive mechanism to the second distribution valve, wherein the second rotational drive mechanism is independent of the first rotational drive mechanism so as to allow for independent port selection.

17. The method of claim 16, further comprising: aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that the first rotational drive mechanism axis and the second rotational drive mechanism axis are concentric.

18. The method of claim 16, further comprising: aligning a first rotational drive mechanism axis of the first rotational drive mechanism and a second rotational drive mechanism axis of the second rotational drive mechanism such that and the second rotational drive mechanism axis is radially offset from the first rotational drive mechanism axis within a range of 0.1 to 5mm.

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19. The method of claim 16, wherein the first distribution valve comprises a rotary feedback device, and wherein the method further comprises: setting a valve zero position in the rotary feedback device by inserting a pin in a, radial section of a fluid channel disposed in first distribution valve, and programing the rotary feedback device accordingly.

20. The method of claim 19, wherein the rotary feedback device is an encoder.

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