WO2022120531A1 - Procédé et appareil de quantification de transfert de saturation par échange chimique pour résonance magnétique, et support - Google Patents

Procédé et appareil de quantification de transfert de saturation par échange chimique pour résonance magnétique, et support Download PDF

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WO2022120531A1
WO2022120531A1 PCT/CN2020/134317 CN2020134317W WO2022120531A1 WO 2022120531 A1 WO2022120531 A1 WO 2022120531A1 CN 2020134317 W CN2020134317 W CN 2020134317W WO 2022120531 A1 WO2022120531 A1 WO 2022120531A1
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water
steady
relaxation rate
under
magnetic resonance
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PCT/CN2020/134317
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Chinese (zh)
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吴垠
郑海荣
刘新
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中国科学院深圳先进技术研究院
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/561—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

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  • the present application relates to the field of biomedical engineering, in particular to a quantitative method, device and medium for chemical exchange saturation transfer for magnetic resonance.
  • Magnetic resonance chemical exchange saturation transfer (CEST) imaging is an important imaging method for non-invasive acquisition of biological tissue molecular information using endogenous or exogenous CEST contrast agents. Sufficient saturation of the CEST contrast agent and sufficient recovery of the saturated water molecule signal are necessary conditions for obtaining a steady-state CEST signal and determine the accuracy of the quantification of the CEST effect.
  • the quantification of the CEST effect is very complex, affected by many factors, and is closely related to important imaging parameters such as saturation time (Ts) and recovery time (Td), that is, the quantitative results of CEST are highly dependent on imaging parameters.
  • Ts saturation time
  • Td recovery time
  • the saturation time is restricted by factors such as the hardware system and the specific absorption rate, and the long-term saturation and recovery will greatly increase the scanning time, which is very difficult in practical applications.
  • most CEST imaging studies are usually carried out under the conditions of short saturation time and recovery time (that is, under non-steady-state experimental conditions), which cannot guarantee sufficient saturation and recovery, and the obtained CEST signal is also in non-steady state. This can lead to an underestimation of the CEST effect, preventing accurate and stable CEST quantification.
  • the main technical problem to be solved by the present application is to provide a quantitative method, device and medium for chemical exchange saturation transfer for magnetic resonance.
  • the steady-state CEST signal can be calculated from the non-steady-state CEST signal, and based on the obtained steady state CEST signal A stable and accurate quantification of the CEST effect is achieved by using the state CEST signal.
  • a technical solution adopted in the present application is to provide a quantitative method for chemical exchange saturation transfer for magnetic resonance, the quantitative method includes: obtaining the longitudinal relaxation rate of water; presetting based on unsteady experimental conditions.
  • the deformation formula for calculating the spin-lock relaxation rate of water under the following equation, at least one deformation parameter of the deformation formula is the ratio of the saturated signal under the unsteady experimental condition to the unsaturated reference signal; obtain the unsaturated reference under the unsteady experimental condition Signal and saturation signal, saturation time and recovery time, and calculate the deformation formula according to the non-saturated reference signal and saturation signal, saturation time and recovery time and the longitudinal relaxation rate of water under non-steady state experimental conditions to obtain the spin lock of water Relaxation rate; based on the longitudinal relaxation rate of water and the spin-lock relaxation rate of water, obtain the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions; based on the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions Obtain the magnetic resonance chemical exchange saturation transfer effect under steady state experimental conditions.
  • a deformation formula for calculating the spin-lock relaxation rate of water under unsteady experimental conditions is preset, and at least one deformation parameter of the deformation formula is the ratio of the saturated signal to the non-saturated reference signal under the unsteady experimental conditions Specifically, it includes: obtaining the non-saturated reference signal and the calculation formula of the saturated signal under non-steady-state experimental conditions:
  • the steps of acquiring the magnetic resonance chemical exchange saturation transfer signal under the steady-state experimental condition specifically include: acquiring the saturation signal and the unsaturated signal under the steady-state experimental condition The ratio formula of the reference signal; when the saturation time is long enough under the preset steady-state experimental conditions, the ratio formula is rewritten to obtain the rewritten ratio formula; based on the rewritten ratio formula, the longitudinal relaxation rate of water and the automatic The spin-lock relaxation rate was calculated to obtain the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions.
  • I is the saturation signal under steady-state experimental conditions.
  • the steps of rewriting the comparison value formula specifically include: the saturation time under the preset steady-state experimental conditions is infinite, then The value of is 0, and the rewritten ratio formula is:
  • the longitudinal relaxation rate of water and the spin-lock relaxation rate of water are calculated based on the rewritten ratio formula, and the steps of obtaining the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions specifically include: based on the rewritten ratio formula
  • the ratio formula calculates the longitudinal relaxation rate of water and the spin-lock relaxation rate of water to obtain the ratio of I/I 0 .
  • the step of acquiring the longitudinal relaxation rate of water specifically includes: acquiring the longitudinal relaxation rate of water based on a conventional magnetic resonance quantitative technology.
  • conventional magnetic resonance quantitative technology includes T 1 mapping technology.
  • a chemical exchange saturation transfer quantitative device for magnetic resonance comprising: a memory for storing program data, and when the program data is executed, it can realize the following: The steps in the chemical exchange saturation transfer quantitative method for magnetic resonance described in any one of the above; a processor for executing program instructions stored in a memory to realize the chemical exchange for magnetic resonance as described in any of the above Steps in a quantification method for saturation transfer.
  • Another technical solution adopted in the present application is to provide a computer-readable storage medium, where a computer program is stored on the computer-readable storage medium. Steps in a quantitative method for chemical exchange saturation transfer for magnetic resonance.
  • the beneficial effects of the present application are: different from the prior art, the present application can calculate and obtain the steady-state CEST signal based on the non-steady-state CEST signal through a preset deformation formula, remove the influence of imaging parameters on the CEST quantitative result, and solve the problem of non-steady-state CEST signal. Under the condition of steady-state imaging, the CEST effect is underestimated, and the quantitative results are highly dependent on the imaging parameters, which improves the accuracy of CEST quantification; further, the present application can speed up the CEST quantitative accuracy without affecting the Imaging speed, improve the efficiency of imaging research.
  • 1 is a schematic flow diagram of an embodiment of the chemical exchange saturation transfer quantitative method for magnetic resonance in the present application
  • Fig. 2 is the sub-flow chart of step S12 in Fig. 1;
  • Fig. 3 is the sub-flow chart of step S14 in Fig. 1;
  • Example 4 is a schematic diagram of the comparison of the unsteady CEST signals obtained in Example 1 of the present application and Comparative Example 1 and the corresponding quantitative results of the CEST effect obtained by calculation;
  • FIG. 5 is a schematic structural diagram of an embodiment of the chemical exchange saturation transfer quantitative device for magnetic resonance of the present application.
  • FIG. 6 is a schematic structural diagram of an embodiment of a computer-readable storage medium of the present application.
  • Magnetic resonance chemical exchange saturation transfer (CEST) imaging is a magnetic resonance molecular imaging method that can detect the characteristics of the microenvironment of biological tissues, and can measure endogenous metabolites, compounds (such as glucose, glycogen, amide protons, etc.)
  • Derived paramagnetic/diamagnetic CEST contrast agents provide new methods for imaging a variety of diseases (such as stroke, tumor, epilepsy, etc.).
  • the quantification of the CEST effect is very complex and is affected by many factors, which are closely related to important imaging parameters such as saturation time (Ts) and recovery time (Td).
  • Ts saturation time
  • Td recovery time
  • the CEST effect is the superposition of two processes, namely: the signal reduction of the CEST contrast agent due to the saturation effect and the signal recovery of the water molecule through the relaxation process. Sufficient long-term saturation and relaxation recovery are prerequisites for the CEST signal to reach a steady state.
  • most current CEST imaging studies are usually performed under the condition of short saturation time and recovery time. implemented, that is, the resulting CEST signal is in a non-steady state. This approach leads to an underestimation of the CEST effect, and is not conducive to cross-sectional comparisons and results from studies under different imaging conditions.
  • the present application provides a quantitative method for chemical exchange saturation transfer for magnetic resonance, through a preset deformation formula, the steady-state CEST signal can be obtained by calculating the non-steady-state CEST signal.
  • the quantitative method for chemical exchange saturation transfer for magnetic resonance includes: obtaining the longitudinal relaxation rate of water; presetting a deformation formula based on calculating the spin-lock relaxation rate of water under unsteady experimental conditions, the deformation At least one deformation parameter of the formula is the ratio of the saturated signal and the non-saturated reference signal under the non-steady state experimental conditions; the non-saturated reference signal and the saturated signal, the saturation time and the recovery time under the non-steady state experimental conditions are obtained.
  • the non-saturated reference signal and saturation signal, saturation time and recovery time, and the longitudinal relaxation rate of water under the experimental conditions of the state are calculated and deformed to obtain the spin-lock relaxation rate of water;
  • the spin-lock relaxation rate is used to obtain the magnetic resonance chemical exchange saturation transfer signal under the steady-state experimental condition;
  • the magnetic resonance chemical exchange saturation transfer effect under the steady-state experimental condition is obtained based on the magnetic resonance chemical exchange saturation transfer signal under the steady-state experimental condition.
  • the present application can calculate and obtain the steady-state CEST signal based on the non-steady-state CEST signal through the preset deformation formula, thereby removing the influence of imaging parameters on the CEST effect and improving the accuracy of CEST quantification; further, the present application can also be used in Under the premise of not affecting the quantitative accuracy of CEST, the imaging speed is accelerated and the imaging research efficiency is improved.
  • FIG. 1 is a schematic flowchart of an embodiment of the chemical exchange saturation transfer quantitative method for magnetic resonance of the present application.
  • the quantitative method includes:
  • the longitudinal relaxation rate of the water is obtained based on conventional magnetic resonance quantitative technology.
  • the longitudinal relaxation rate of water is the inverse of the longitudinal relaxation time of water.
  • the relaxation process of water includes the longitudinal relaxation time (T1), and the longitudinal relaxation rate R 1w of water is 1/T1.
  • conventional magnetic resonance quantitative techniques include T1mapping techniques.
  • T1mapping is to directly measure the value of T1, and through the value of T1, the longitudinal relaxation rate R 1w of water can be obtained.
  • S12 Preset a deformation formula for calculating the spin-lock relaxation rate of water under unsteady experimental conditions, and at least one deformation parameter of the deformation formula is a ratio of a saturated signal to a non-saturated reference signal under unsteady experimental conditions.
  • the non-steady-state experimental conditions refer to insufficient saturation and recovery conditions, that is, experiments are performed under the conditions of short saturation time and recovery time.
  • the non-saturated reference signal and the saturated signal, the saturation time and the recovery time under the non-steady state experimental conditions are all data obtained directly in the experiment.
  • the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions is calculated and obtained.
  • the angle ⁇ at which the saturation radio frequency pulse flips the magnetization vector of water is the data obtained directly in the experiment.
  • the present application can calculate and obtain the steady-state CEST signal based on the non-steady-state CEST signal through a preset deformation formula, which solves the problem that the CEST effect is underestimated under non-steady-state imaging conditions, and the quantitative result is highly dependent on imaging.
  • the disadvantages of the parameters improve the accuracy of CEST quantification; further, the present application removes the influence of imaging parameters on the CEST effect, and avoids that the quantitative results are highly dependent on the imaging parameters, so it can be achieved without affecting the quantitative accuracy of CEST. It can speed up the imaging speed and improve the efficiency of imaging research.
  • FIG. 2 is a sub-flow chart of step S12 in FIG. 1 .
  • a deformation formula for calculating the spin-lock relaxation rate of water under unsteady experimental conditions is preset, and at least one deformation parameter of the deformation formula is saturation under unsteady experimental conditions.
  • the step of the ratio of the signal to the non-saturated reference signal specifically includes:
  • e is an infinite non-repeating decimal with a value between 2.7 and 2.8.
  • the value of e is about 2.718281828.
  • the calculation formulas of the non-saturated reference signal and the saturated signal under the non-steady state experimental conditions are the existing formulas.
  • S24 Rewrite the second equation to obtain a deformation formula; at least one deformation parameter of the deformation formula is a ratio of a saturated signal to a non-saturated reference signal under non-steady state experimental conditions.
  • one of the deformation parameters on the left side of the equation of the deformation formula is the saturated signal I app and the non-saturated reference signal under the unsteady experimental conditions. ratio.
  • the non-saturated reference signal under non-steady-state experimental conditions
  • the saturation signal I app , the saturation time Ts and the recovery time Td, and the angle ⁇ at which the magnetization vector of the water is flipped by the saturation radio frequency pulse are all directly obtained in the experiment.
  • the longitudinal relaxation rate R 1w of water can be calculated by the T1mapping technique. Therefore, , the only unknown A in the deformation formula can be obtained by fitting these known data, and then the spin-lock relaxation rate R 1 ⁇ of water can be obtained through A.
  • FIG. 3 is a sub-flow chart of step S14 in FIG. 1 .
  • the step of acquiring the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions specifically includes:
  • I is the saturation signal under steady-state experimental conditions.
  • the formula for the ratio of the saturated signal to the non-saturated reference signal under steady-state experimental conditions is an existing formula.
  • the saturation time under the preset steady-state experimental conditions can be preset to be infinite, and when Ts is ⁇ , is 0, then the rewritten ratio formula obtained is:
  • the longitudinal relaxation rate R 1w of water is calculated by the T 1 mapping technique
  • the spin-lock relaxation rate R 1 ⁇ of water is calculated by the deformation formula
  • the angle ⁇ at which the saturation radio frequency pulse flips the magnetization vector of water is The data obtained directly in the experiment can therefore be calculated based on the rewritten ratio formula to calculate the longitudinal relaxation rate of water and the spin-lock relaxation rate of water to obtain the ratio of I/I 0 .
  • the ratio of I/I 0 is the magnetic resonance chemical exchange saturation transfer signal under steady-state experimental conditions.
  • the deformation formula is preset in the present application, and the spin-lock relaxation rate of water can be obtained by calculating the non-saturated reference signal and the saturated signal under non-steady-state experimental conditions, and based on the longitudinal relaxation rate of water and water
  • the spin-lock relaxation rate is obtained, and the magnetic resonance chemical exchange saturation transfer signal under the steady-state experimental condition can be obtained, that is, the application can calculate the steady-state CEST signal based on the unsteady CEST signal, and solve the CEST effect under the unsteady imaging condition.
  • the ratios of amide protons (resonance frequency at 3.5 ppm relative to water) and semisolid macromolecules (resonance frequency at 0 ppm relative to water) relative to water were 0.1% and 13.9%, respectively, corresponding to exchange rates of 30 Hz and 23 Hz.
  • the CEST signal as well as the CEST effect were calculated by the chemical exchange saturation transfer quantitative method for magnetic resonance provided herein.
  • the chemical exchange process of water, semisolid macromolecules and amide protons (amide) is simulated using the classical three-cell Bloch McConnell equation. Assuming that under the 11.7 Tesla magnetic field environment, the longitudinal relaxation rate of water is 0.5 Hz and the transverse relaxation rate is 30 Hz; the longitudinal relaxation rate of the amide proton is 1 Hz and the transverse relaxation rate is 66.7 Hz; the longitudinal relaxation rate of the semi-solid macromolecule is 1 Hz and the transverse relaxation rate is 1 Hz. Relaxation rate 105Hz.
  • the ratios of amide protons (resonance frequency at 3.5 ppm relative to water) and semisolid macromolecules (resonance frequency at 0 ppm relative to water) relative to water were 0.1% and 13.9%, respectively, corresponding to exchange rates of 30 Hz and 23 Hz.
  • the unsaturated reference signal under , ⁇ is the chemical shift relative to the water molecule.
  • FIG. 4 is a comparative schematic diagram of the unsteady CEST signals obtained in Example 1 of the present application and Comparative Example 1 and the corresponding quantitative results of the CEST effect obtained by calculation.
  • Figure a) is the unsteady CEST signal obtained by simulation in Comparative Example 1
  • Figure b) is the corresponding quantitative result of CEST effect calculated by asymmetric analysis method in Comparative Example 1
  • Ts/Td are 2s/2s respectively and 4s/4s
  • Figure c) is the steady-state CEST signal obtained by the calculation of the preset formula of the application in the embodiment 1
  • Figure d) is the quantitative result of the CEST effect calculated by the algorithm of the application in the embodiment 1.
  • Schematic diagrams when Ts/Td are 2s/2s and 4s/4s, respectively.
  • the obtained CEST effect shows that the algorithm provided in this application can remove the influence of imaging parameters such as Ts and Td on CEST quantification, and solves the drawback of underestimated CEST effect under non-steady-state imaging conditions, thereby realizing non-steady-state imaging. Accurate and stable quantification of CEST steady-state signals under conditions. Further, since the present application removes the influence of imaging parameters on the CEST effect, it avoids that the quantitative results are highly dependent on the imaging parameters, and thus can speed up the imaging speed and improve the efficiency of imaging research without affecting the quantitative accuracy of CEST.
  • imaging parameters such as Ts and Td on CEST quantification
  • the present application can calculate and obtain the steady-state CEST signal based on the non-steady-state CEST signal through a preset deformation formula, which solves the problem that the CEST effect is underestimated under non-steady-state imaging conditions, and the quantitative result is highly dependent on imaging.
  • the disadvantages of the parameters improve the accuracy of CEST quantification; further, the present application removes the influence of imaging parameters on the CEST effect, and avoids that the quantitative results are highly dependent on the imaging parameters, so it can be used without affecting the quantitative accuracy of CEST. It can speed up the imaging speed and improve the efficiency of imaging research.
  • the present application provides a chemical exchange saturation transfer quantitative device for magnetic resonance.
  • FIG. 5 is a schematic structural diagram of an embodiment of the chemical exchange saturation transfer quantitative device for magnetic resonance of the present application.
  • the chemical exchange saturation transfer quantitative device 50 for magnetic resonance includes a processor 51 and a memory 52 coupled to each other.
  • the memory 52 is used to store program data, and when the program data is executed, the steps in the chemical exchange saturation transfer quantitative method for magnetic resonance as described in any of the above can be implemented;
  • the processor 51 is used to execute the memory 52 Stored program instructions to implement the steps in any of the above method embodiments or the corresponding steps performed by the chemical exchange saturation transfer quantitative apparatus for magnetic resonance in any of the above method embodiments.
  • the chemical exchange saturation transfer quantitative device 50 for magnetic resonance may also include a touch screen, a communication circuit, etc. as required, which is not limited herein.
  • the processor 51 is used to control itself and the memory 52 to implement the steps in any of the above-mentioned embodiments of the chemical exchange saturation transfer quantitative method for magnetic resonance.
  • the processor 51 may also be referred to as a CPU (Central Processing Unit, central processing unit).
  • the processor 51 may be an integrated circuit chip with signal processing capability.
  • the processor 51 may also be a general-purpose processor, a digital signal processor (Digital Signal Processor, DSP), an application specific integrated circuit (Application Specific Integrated Circuit, ASIC), a field programmable gate array (Field-Programmable Gate Array, FPGA) or other Programmable logic devices, discrete gate or transistor logic devices, discrete hardware components.
  • a general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.
  • the processor 51 may be jointly implemented by a plurality of integrated circuit chips.
  • the present application provides a computer-readable storage medium.
  • FIG. 6 is a schematic structural diagram of an embodiment of a computer-readable storage medium of the present application.
  • the computer-readable storage medium 60 includes a computer program 601 stored on the computer-readable storage medium 60.
  • the computer program 601 is executed by the foregoing processor, the steps in any of the foregoing method embodiments or the steps in the foregoing method embodiments for magnetic resonance are implemented.
  • the chemical exchange saturation transfer quantitative device corresponds to the steps performed.
  • the integrated units are implemented in the form of software functional units and sold or used as independent products, they may be stored in a computer-readable storage medium 60 .
  • the storage medium 60 includes several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) or a processor (processor) to execute all or part of the steps of the methods of the various embodiments of the present application.
  • the aforementioned computer-readable storage medium 50 includes: a USB flash drive, a removable hard disk, a read-only memory (ROM, Read-Only Memory), a random access memory (RAM, Random Access Memory), a magnetic disk or an optical disk, etc. medium of program code.
  • the disclosed method and apparatus may be implemented in other manners.
  • the apparatus implementations described above are only illustrative, for example, the division of modules or units is only a logical function division, and there may be other divisions in actual implementation, for example, multiple units or components may be combined or Can be integrated into another system, or some features can be ignored, or not implemented.
  • the shown or discussed mutual coupling or direct coupling or communication connection may be through some interfaces, indirect coupling or communication connection of devices or units, which may be in electrical, mechanical or other forms.
  • Units described as separate components may or may not be physically separated, and components shown as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution in this implementation manner.
  • each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically alone, or two or more units may be integrated into one unit.
  • the above-mentioned integrated units may be implemented in the form of hardware, or may be implemented in the form of software functional units.
  • the integrated unit if implemented as a software functional unit and sold or used as a stand-alone product, may be stored in a computer-readable storage medium.
  • the technical solutions of the present application can be embodied in the form of software products in essence, or the parts that contribute to the prior art, or all or part of the technical solutions, and the computer software products are stored in a storage medium , including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) or a processor (processor) to execute all or part of the steps of the methods of the various embodiments of the present application.
  • the aforementioned storage medium includes: U disk, mobile hard disk, Read-Only Memory (ROM, Read-Only Memory), Random Access Memory (RAM, Random Access Memory), magnetic disk or optical disk and other media that can store program codes .

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Abstract

La présente invention concerne un procédé et un appareil (50) de quantification de transfert de saturation par échange chimique (CEST) pour une résonance magnétique, et un support, se rapportant au domaine de l'ingénierie biomédicale. Le procédé de quantification comprend les étapes consistant à : obtenir un taux de relaxation longitudinale de l'eau (S11); établir préalablement une équation variante pour calculer un taux de relaxation de verrouillage de spin de l'eau dans des conditions expérimentales non stationnaires, au moins un paramètre variant de l'équation variante étant le rapport signal de saturation sur signal de référence sans saturation dans les conditions expérimentales non stationnaires (S12); obtenir une pluralité de paramètres dans les conditions expérimentales non stationnaires, et résoudre l'équation variante en fonction des paramètres pour obtenir le taux de relaxation de verrouillage de spin de l'eau (S13); obtenir un signal CEST de résonance magnétique dans des conditions expérimentales stationnaires sur la base du taux de relaxation longitudinale de l'eau et du taux de relaxation de verrouillage de spin de l'eau (S14); et obtenir un effet CEST de résonance magnétique dans les conditions expérimentales stationnaires sur la base du signal (S15). Un signal CEST en régime stationnaire peut être obtenu par le calcul sur la base d'un signal CEST en régime non stationnaire, l'influence des paramètres d'imagerie sur un résultat de quantification de CEST est éliminé, et la précision de la quantification de CEST est améliorée.
PCT/CN2020/134317 2020-12-07 2020-12-07 Procédé et appareil de quantification de transfert de saturation par échange chimique pour résonance magnétique, et support WO2022120531A1 (fr)

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