WO2022118347A1 - System for a physiological transcranial magnetic stimulation of brain tissue - Google Patents

System for a physiological transcranial magnetic stimulation of brain tissue Download PDF

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Publication number
WO2022118347A1
WO2022118347A1 PCT/IT2021/050249 IT2021050249W WO2022118347A1 WO 2022118347 A1 WO2022118347 A1 WO 2022118347A1 IT 2021050249 W IT2021050249 W IT 2021050249W WO 2022118347 A1 WO2022118347 A1 WO 2022118347A1
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Prior art keywords
physiological
patient
ftms
head
magnetic stimulation
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PCT/IT2021/050249
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French (fr)
Inventor
Federica PECI
Original Assignee
Cerebro S.R.L.
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Publication of WO2022118347A1 publication Critical patent/WO2022118347A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/008—Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia

Definitions

  • the present invention relates to a system for physiological transcranial magnetic stimulation (fTMS) of brain tissue, for use in the neurorehabilitation field.
  • fTMS physiological transcranial magnetic stimulation
  • This device represents the evolution of TMS (Transcranial Magnetic Stimulation) which is a non-invasive technique of electromagnetic stimulation of brain tissue carried out by placing powerful magnets near the skin. Using this technique, it is possible to stimulate and study the functioning of the circuits and neuronal connections of the brain, causing a rather small and transient alteration of the electrical activity. Said electrical activity being limited to the outermost tissues. TMS is used for brain mapping research on responses to various stimulations and also as a tool for the treatment of various pathologies or disorders in the neurological field .
  • TMS Transcranial Magnetic Stimulation
  • TMS currently on the market only use a pulsating magnetic field that allows you to reach the deeper layers of the cortex and subcortical areas but at the same time produces numerous undesirable and contralateral ef fect s during and following treatment (noise in the ears , transient or persistent headache after treatment , irritation at the coil application area, nausea ) .
  • the model underlying this method provides that a deficient area in one hemisphere can be supported and enhanced by the activity of it s homologous area in the contralateral hemisphere .
  • the ob j ect of the present invention is to provide a device which implements said method and acts only on the external cortical surface, so as not to have the numerous undesirable and contralateral effects during and following treatment, typical of TMS of the prior art.
  • the system for physiological transcranial magnetic stimulation (fTMS) of brain tissue for use in the neuropsychiatric field, of the type that involves the use of a magnetic field capable of generating a low Hertz electric current, is characterized by the fact that it includes:
  • the method for physiological transcramal magnetic stimulation ( fTMS ) of brain tis sue for use in the neuro-rehabilitation field, of the type that involves the use of a static magnetic field capable of generating a low Hert z electric current , is characterized by the fact that said electric current interact s with the bioelectric field of the neuronal system, said combination of magnetic force and bioelectric force being put in connection with two cables connected to solenoids positioned on homologous functional brain areas of the two cerebral hemispheres by connecting said two homologous areas in a way such that a deficient area in one hemisphere can be supported and enhanced by the activity of it s homologous area in the contralateral hemisphere .
  • Preferred embodiment s and non-trivial variant s of the present invention form the sub j ect of the dependent claims .
  • the solenoids collect the basic electrical function of the healthy area, reproducing it in support of the damaged one , rebalancing the two cerebral hemispheres and improving communication between them .
  • the device uses the stable magnetic field present in the body of the device it self as an impulse propeller .
  • physiological transcranial magnetic stimulation is a non-invasive and painles s treatment , based on electromagnetic stimulation capable of positively influencing neuronal plasticity .
  • the disorders treated with fTMS are related to problems of inter-hemispheric connection or in pathologies in which a specific area is af fected in one of the two hemispheres .
  • the underlying idea of this method lies in the fact that since the magnetic field produced is of low intensity and static, it will facilitate the neuronal restructuring of the area in the in jured hemisphere thanks to the functional integrity of the homologous area of the opposite hemisphere .
  • the functioning of static magnetism facilitates the brain area in difficulty by exploiting the integrity of its own contralateral homologous area .
  • pathologies that primarily affect brain areas of only one hemisphere and then pathologies derived from acquired post-birth brain damage in adults are treated below.
  • FIG. 1 shows a system according to the invention
  • FIG. 2 and 3 show a device for generating a low Hertz current through a static magnetic field
  • FIG. 4 shows a coil for generating the electromagnetic field to be applied to the patient's head
  • FIG. 5 shows a silicone cuff, to be applied to the patient' s head to keep said coils in position on the patient's head.
  • (1) indicates the set of components of a system according to the invention.
  • Said system (1) includes:
  • the device (1) (FIG. 2, 3) for generating a low Hertz current comprises: - a machine body (2) on which are obtained:
  • a plurality of vertical axis lodges (5) (for example eight in number) arranged along a circumference and adapted to house spherical magnets (6) , each of said lodges (5) being in communication with the lower part of said machine body (2) through coaxial holes (5a) with said lodges (5) ;
  • a lid (7) preferably conical in shape, which engages on said first cylindrical cavity (3) , so as to close it;
  • FIG. 3 a spider structure (13) (FIG. 3) , made of conductive PLA conductive material, placed under the machine body (2) and comprising a number of arms (13a) equal to the number of loggias (5) , the ends of said arms (13a) being bent at right angles to fit into said holes (5a) , so as to support said spherical magnets (6) .
  • Said spider structure (13) comprises a central part consisting of a copper winding (14) , the two ends of which flow individually into suitable female jack sockets (15) .
  • FIG. 4 shows one of said coils (lb) .
  • the coil (lb) which has a butterfly shape to facilitate the penetration of the electromagnetic field inside the patient's scalp, includes a silicone body (20) , which incorporates a pair of solenoids (21a, 21b) , electrically connected, by means of a cable (22) , with a male jack plug (23) , to be inserted in said female jack socket (15) .
  • the coil is made of conductive PLA material characterized by a resistivity of about 15 ohm/ cm along the layers and 20 ohm/ cm perpendicular to the layers, AlfaOhm is completely non-toxic and odorless up to high temperatures .
  • the coil (lb) also comprises a pair of hooks (24a, 24b) which have the function of fixing said coil (lb) inside said cap (lc) , so as to keep it fixed in the chosen location.
  • the butterfly shape of the coil (lb) allows a much more focal penetration than a single coil and is maximum in the central part of the coil (lb) , i.e. where the two solenoids (21a, 21b) meet.
  • the butterfly shape that is, the double coil, conveys the magnetic stimulation to the exact point of the cortical cerebral area to be treated .
  • FIG. 5 shows said silicone cap (lc) .
  • the point (Cz) on the top of the cap (lc) represents an important landmark together with Nasion, Inion and the ear points (Al) and (A2) to allow the correct centering of the cap on the head.
  • the point (Cz) on the top of the cap (lc) represents an important landmark together with Nasion, Inion and the ear points (Al) and (A2) to allow the correct centering of the cap on the head.
  • nasal point is the midpoint of the nasal-frontal suture
  • - Auricle (1 and 2) are the highest points of the upper edge of the external acoustic meatus (left and right) ;
  • the area (Cz) is the point of intersection between the central sulcus and the median line; it is obtained from the intersection of Nasion, Inion, (Al) and (A2) and corresponds to the central point between (C3) and (C4) .
  • FIG. 5 shows the mapping of the fTMS cuff to the respective coded brain areas.
  • the fTMS follows the international 10-20 mapping of brain areas. These areas are:
  • F3 and F4 (Brodmann area 8) , identified as part of the frontal cortex, include the frontal visual fields (so called because they are believed to play an important role in the control of eye movements) ;
  • C3 and C4 (Brodmann areas 01 and 04) , identify different central areas always inserted within the primary motor cortex following Penfield's Homunculus with the representation of the legs and trunk that bend all 'interior of the midline;
  • T3 and T4 (Brodmann area 22) , identify part of the temporal cortex
  • T5 and T6 (Brodmann area 37) , identify part of the temporal lobe in the cerebral cortex;
  • the system (1) according to the invention is used by inserting the pair of coils (lb) in the internal part of the cap (lc) , in correspondence with the areas to be treated. Then the cuff (lc) is secured to the patient's head and the plugs (23) are inserted into the respective sockets (15) on the device (1) , which will be operated as follows .
  • the closing cone (7) acts as a "switch" of the electromagnetic force generated inside the central body (2) . If the cone (7) is positioned so as to close the first cylindrical cavity (3) , the first magnet (10) , positioned below the cone (7) itself, enters into magnetic attraction with the second magnet (11) positioned at the top of the cavity (4) , interrupting the electromagnetic field that has been created inside the central body (2 ) .
  • the magnets inside the central body (2) i.e. the second magnet (11) and the third magnet (12) are in magnetic opposition and in axis with respect to the spherical magnets (6) housed in the lodges (5) , distributed along the whole circumference of the central body (2) .

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Abstract

A system (1) is described, for a physiological transcranial magnetic stimulation (fTMS) of brain tissue, for use in the neuro-rehabilitation field, of the type that involves the use of a magnetic field capable of generating a low Hertz electric current; the system (1) comprises: a device (1a) for generating a low-Hertz current, by means of a static magnetic field; a pair of coils (1b), electrically connected to the device (1a), for generating the electromagnetic field to be applied to the patient's head; and a silicone cap (1c), to be applied to the patient's head to keep said coils (1a) in position on said patient's head.

Description

SYSTEM FOR A PHYSIOLOGICAL TRANSCRANIAL MAGNETIC STIMULATION OF BRAIN TISSUE
The present invention relates to a system for physiological transcranial magnetic stimulation (fTMS) of brain tissue, for use in the neurorehabilitation field.
The efficacy of cerebral cortical stimulation in physical/cognit ive rehabilitation is known.
This device represents the evolution of TMS (Transcranial Magnetic Stimulation) which is a non-invasive technique of electromagnetic stimulation of brain tissue carried out by placing powerful magnets near the skin. Using this technique, it is possible to stimulate and study the functioning of the circuits and neuronal connections of the brain, causing a rather small and transient alteration of the electrical activity. Said electrical activity being limited to the outermost tissues. TMS is used for brain mapping research on responses to various stimulations and also as a tool for the treatment of various pathologies or disorders in the neurological field .
Experimental evidence demonstrates this efficacy in the treatment of various pathologies such as : pain, movement disorders , stroke , amyotrophic lateral sclerosis , multiple sclerosis , epilepsy, tinnitus , depres sion, anxiety disorders , obses sive compulsive disorders , schizophrenia and addictions .
TMS currently on the market only use a pulsating magnetic field that allows you to reach the deeper layers of the cortex and subcortical areas but at the same time produces numerous undesirable and contralateral ef fect s during and following treatment (noise in the ears , transient or persistent headache after treatment , irritation at the coil application area, nausea ) .
The model underlying this method provides that a deficient area in one hemisphere can be supported and enhanced by the activity of it s homologous area in the contralateral hemisphere .
The ob j ect of the present invention is to provide a device which implements said method and acts only on the external cortical surface, so as not to have the numerous undesirable and contralateral effects during and following treatment, typical of TMS of the prior art.
The above described and other objects, as will be explained in the following, are achieved with a system and a method conforming respectively to claims 1 and 7.
The system for physiological transcranial magnetic stimulation (fTMS) of brain tissue, for use in the neuropsychiatric field, of the type that involves the use of a magnetic field capable of generating a low Hertz electric current, is characterized by the fact that it includes:
- a device for generating a low Hertz current through a static magnetic field;
- a pair of coils, electrically connected to the device (la) , for generating the electromagnetic field to be applied to the patient's head;
- a silicone cap, to be applied to the patient's head, to keep said coils (la) in position on said patient's head. The method for physiological transcramal magnetic stimulation ( fTMS ) of brain tis sue , for use in the neuro-rehabilitation field, of the type that involves the use of a static magnetic field capable of generating a low Hert z electric current , is characterized by the fact that said electric current interact s with the bioelectric field of the neuronal system, said combination of magnetic force and bioelectric force being put in connection with two cables connected to solenoids positioned on homologous functional brain areas of the two cerebral hemispheres by connecting said two homologous areas in a way such that a deficient area in one hemisphere can be supported and enhanced by the activity of it s homologous area in the contralateral hemisphere .
Preferred embodiment s and non-trivial variant s of the present invention form the sub j ect of the dependent claims .
In practice , the solenoids collect the basic electrical function of the healthy area, reproducing it in support of the damaged one , rebalancing the two cerebral hemispheres and improving communication between them . The device uses the stable magnetic field present in the body of the device it self as an impulse propeller .
Ultimately, physiological transcranial magnetic stimulation ( fTMS ) is a non-invasive and painles s treatment , based on electromagnetic stimulation capable of positively influencing neuronal plasticity .
It is particularly advantageous due to the absence of side ef fect s , which result s in excellent tolerability, with encouraging result s when used in support of rehabilitation proces ses in patient s with motor and cognitive deficit s caused by brain damage , shortening response t ime s .
The disorders treated with fTMS are related to problems of inter-hemispheric connection or in pathologies in which a specific area is af fected in one of the two hemispheres . The underlying idea of this method lies in the fact that since the magnetic field produced is of low intensity and static, it will facilitate the neuronal restructuring of the area in the in jured hemisphere thanks to the functional integrity of the homologous area of the opposite hemisphere . The functioning of static magnetism facilitates the brain area in difficulty by exploiting the integrity of its own contralateral homologous area .
Therefore, pathologies that primarily affect brain areas of only one hemisphere and then pathologies derived from acquired post-birth brain damage in adults are treated below.
It is understood that all the attached claims form an integral part of the present description.
It will be immediately obvious that innumerable variations and modifications (for example relating to shape, dimensions, arrangements and parts with equivalent functionality) can be made to what has been described without departing from the scope of the invention, as appears from the attached claims.
The present invention will be better described by some preferred embodiments, provided by way of non-limiting example, with reference to the attached drawings, in which:
- FIG. 1 shows a system according to the invention;
- FIG. 2 and 3 show a device for generating a low Hertz current through a static magnetic field;
- FIG. 4 shows a coil for generating the electromagnetic field to be applied to the patient's head;
- FIG. 5 shows a silicone cuff, to be applied to the patient' s head to keep said coils in position on the patient's head.
With reference to the attached figures, (1) indicates the set of components of a system according to the invention.
Said system (1) includes:
- a device (la) for generating a low Hertz current by means of a static magnetic field;
- a pair of coils (lb) , electrically connected to the device (la) , for generating the electromagnetic field to be applied to the patient's head;
- a silicone cap (lc) , to be applied to the patient's head to keep said coils (la) in position on said patient's head.
The device (1) (FIG. 2, 3) for generating a low Hertz current comprises: - a machine body (2) on which are obtained:
- a first cylindrical cavity (3) in the upper part ;
- a second cylindrical cavity (4) in the lower part ;
- a plurality of vertical axis lodges (5) (for example eight in number) arranged along a circumference and adapted to house spherical magnets (6) , each of said lodges (5) being in communication with the lower part of said machine body (2) through coaxial holes (5a) with said lodges (5) ;
- a lid (7) , preferably conical in shape, which engages on said first cylindrical cavity (3) , so as to close it;
- a bottom (8) that closes the machine body (2) in the lower part, said bottom (8) being provided with a knob (9) suitable for allowing its removal and, therefore, access to the inside of the machine body (2 ) ;
- a first magnet (10) placed, in an axial position, under said cover (7) , so as to face said first cylindrical cavity (3) ; - a second magnet (11) placed, in an axial position, in the upper part of said second cylindrical cavity (4) ;
- a third magnet (12) housed at the base of the closure where there is said knob (9) for opening the machine body (2) ;
- a spider structure (13) (FIG. 3) , made of conductive PLA conductive material, placed under the machine body (2) and comprising a number of arms (13a) equal to the number of loggias (5) , the ends of said arms (13a) being bent at right angles to fit into said holes (5a) , so as to support said spherical magnets (6) .
Said spider structure (13) comprises a central part consisting of a copper winding (14) , the two ends of which flow individually into suitable female jack sockets (15) .
In FIG. 4 shows one of said coils (lb) . The coil (lb) , which has a butterfly shape to facilitate the penetration of the electromagnetic field inside the patient's scalp, includes a silicone body (20) , which incorporates a pair of solenoids (21a, 21b) , electrically connected, by means of a cable (22) , with a male jack plug (23) , to be inserted in said female jack socket (15) . The coil is made of conductive PLA material characterized by a resistivity of about 15 ohm/ cm along the layers and 20 ohm/ cm perpendicular to the layers, AlfaOhm is completely non-toxic and odorless up to high temperatures .
According to a preferred embodiment, the coil (lb) also comprises a pair of hooks (24a, 24b) which have the function of fixing said coil (lb) inside said cap (lc) , so as to keep it fixed in the chosen location.
The butterfly shape of the coil (lb) allows a much more focal penetration than a single coil and is maximum in the central part of the coil (lb) , i.e. where the two solenoids (21a, 21b) meet. The butterfly shape, that is, the double coil, conveys the magnetic stimulation to the exact point of the cortical cerebral area to be treated .
FIG. 5 shows said silicone cap (lc) . The point (Cz) on the top of the cap (lc) represents an important landmark together with Nasion, Inion and the ear points (Al) and (A2) to allow the correct centering of the cap on the head. In particular :
- Nasion (nasal point) is the midpoint of the nasal-frontal suture;
- Inion is the most prominent midpoint of the occipital protuberance;
- Auricle (1 and 2) are the highest points of the upper edge of the external acoustic meatus (left and right) ;
- the area (Cz) is the point of intersection between the central sulcus and the median line; it is obtained from the intersection of Nasion, Inion, (Al) and (A2) and corresponds to the central point between (C3) and (C4) .
FIG. 5 shows the mapping of the fTMS cuff to the respective coded brain areas. The fTMS follows the international 10-20 mapping of brain areas. These areas are:
- the areas (Fpl) and (Fp2) (Brodmann areas 9 and 10) , identified as the frontal pole of the prefrontal cortex which include not only area 10 but also part of Brodmann area 9;
- areas (F3) and (F4) (Brodmann area 8) , identified as part of the frontal cortex, include the frontal visual fields (so called because they are believed to play an important role in the control of eye movements) ;
- areas (F7) and (F8) (Brodmann area 47) , are part of the frontal cortex and have a curvature that goes from the lateral surface of the frontal lobe to the orbital frontal cortex;
- areas (C3) and (C4) (Brodmann areas 01 and 04) , identify different central areas always inserted within the primary motor cortex following Penfield's Homunculus with the representation of the legs and trunk that bend all 'interior of the midline;
- areas (T3) and (T4) (Brodmann area 22) , identify part of the temporal cortex;
- areas (P3) and (P4) (Brodmann area 39) , identify a region of the parietal lobe in the cerebral cortex.
- areas (T5) and (T6) (Brodmann area 37) , identify part of the temporal lobe in the cerebral cortex;
- areas (01) and (02) (Brodmann areas 17 and 18) , identify a region of the occipital lobe in the cerebral cortex.
The system (1) according to the invention is used by inserting the pair of coils (lb) in the internal part of the cap (lc) , in correspondence with the areas to be treated. Then the cuff (lc) is secured to the patient's head and the plugs (23) are inserted into the respective sockets (15) on the device (1) , which will be operated as follows .
The closing cone (7) acts as a "switch" of the electromagnetic force generated inside the central body (2) . If the cone (7) is positioned so as to close the first cylindrical cavity (3) , the first magnet (10) , positioned below the cone (7) itself, enters into magnetic attraction with the second magnet (11) positioned at the top of the cavity (4) , interrupting the electromagnetic field that has been created inside the central body (2 ) .
The magnets inside the central body (2) , i.e. the second magnet (11) and the third magnet (12) are in magnetic opposition and in axis with respect to the spherical magnets (6) housed in the lodges (5) , distributed along the whole circumference of the central body (2) .
When the conical lid (7) does not close the cavity (3) , the opposing force generated by the second magnet (11) and by the third magnet (12) , combined with the plurality of magnets (6) in contact with said conductive spider structure (13) generates an electromagnetic force field which induces in the copper winding (14) a low Hertz current which is sent, through the cables (22) , to the solenoids (21a, 21b) , producing the therapeutic electromagnetic field.

Claims

1. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue, for use in the neuro-rehabilitation field, of the type that involves the use of a magnetic field capable of generating a low Hertz electric current, characterized in that it comprises:
- a device (la) for generating a low-Hertz current, by means of a static magnetic field;
- a pair of coils (lb) , electrically connected to the device (la) , for generating the electromagnetic field to be applied to the patient' s head;
- a silicone cap (lc) , to be applied to the patient's head to keep said coils (la) in position on said patient's head.
2. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue according to claim 1, characterized in that said device (la) for generating a low Hertz current through a static magnetic field comprises:
- a machine body (2) on which are obtained:
- a first cylindrical cavity (3) in the upper part ;
- a second cylindrical cavity (4) in the lower part;
- a plurality of vertical axis lodges (5) (for example eight in number) arranged along a circumference and adapted to house spherical magnets (6) , each of said lodges (5) being in communication with the lower part of said machine body (2) through holes (5a) coaxial with said lodges (5) ;
- a lid (7) , preferably of conical shape, which engages on said first cylindrical cavity (3) , so as to close it;
- a bottom (8) that closes the machine body (2) in the lower part, said bottom (8) being provided with a knob (9) able to allow its removal and, therefore, access to the inside of the machine body (2 ) ;
- a first magnet (10) placed, in an axial position, under said cover (7) , so as to face said first cylindrical cavity (3) ;
- a second magnet (11) placed, in an axial position, in the upper part of said second cylindrical cavity (4) ; - a third magnet (12) housed at the base of the closure where there is said knob (9) for opening the machine body (2) ;
- a spider structure (13) (FIG. 3) , made of conductive PLA conductive material, placed under the machine body (2) and comprising a number of arms (13a) equal to the number of loggias (5) , the ends of said arms (13a) being bent at right angles to fit into said holes (5a) , so as to support said spherical magnets (6) .
3. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue according to claim 2, characterized in that said spider structure (13) comprises a central part consisting of a copper winding (14) , the two ends of which flow individually into special female jacks (15) .
4. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue according to claim 1, characterized in that said coils (lb) , electrically connected to the device (la) , for the generation of the electromagnetic field to be applied to the patient's head, have a butterfly shape and include a silicone body (20) , which incorporates a pair of solenoids (21a, 21b) , electrically connected, via a cable (22) , with a male jack plug (23) , to be inserted in said female jack (15) , the coil being made of conductive PLA material characterized by a resistivity of about 15 ohm/ cm along the layers and 20 ohm/ cm perpendicular to the layers, AlfaOhm being completely non-toxic and odorless up to high temperatures, this being also designed to be made of all other possible conductive materials, for example copper.
5. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue according to claim 4, characterized in that it provides for a pair of hooks (24a, 24b) which have the function of fixing said coil (lb) to the inside of said cap (lc) , so as to keep it fixed in the selected position.
6. System (1) for a physiological transcranial magnetic stimulation (fTMS) of brain tissue according to claim 1, characterized in that it provides, inside said cuff (lc) , to be applied to the patient's head to keep it in position said coils (la) on the patient's head, suitable hooks to keep said coils (lb) in position during the execution of the therapy .
7 . Method for a physiological transcranial magnetic stimulation ( fTMS ) of brain tis sue , for use in the neuro-rehabilitation field, of the type that involves the use of a static magnetic field capable of generating a low-Hert z electric current , characterized in that said electric current interact s with the bioelectric field of the neuronal system, said combination of magnetic force and bioelectric force being connected with two cables connected to solenoids ( 21a, 21b ) positioned on homologous functional brain areas of the two cerebral hemispheres by connecting said two homologous areas so that a deficient area in one hemisphere can be supported and enhanced by the activity of it s homologous area in the contralateral hemisphere .
8 . Method for a physiological transcranial magnetic stimulation ( fTMS ) of brain tis sue according to claim 7 , characterized in that it is carried out by means of a system according to claims 1 to 6 and comprises the following steps :
- inserting the pair of coils ( lb ) in the internal part of the cap ( l c ) , in correspondence with the areas to be treated;
- fixing the cuff (lc) to the patient's head;
- inserting the pins (23) into the respective sockets (15) on the device (1) , which will be operated as follows;
- activating the device (la) by removing the cover ( 7 ) .
PCT/IT2021/050249 2020-12-02 2021-08-05 System for a physiological transcranial magnetic stimulation of brain tissue WO2022118347A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102020000028589A IT202000028589A1 (en) 2020-12-02 2020-12-02 DEVICE FOR PHYSIOLOGICAL TRANSCRANIAL MAGNETIC STIMULATION OF THE BRAIN TISSUE
IT102020000028589 2020-12-02

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