WO2022115063A1 - A composition of a food supplement and production method thereof - Google Patents
A composition of a food supplement and production method thereof Download PDFInfo
- Publication number
- WO2022115063A1 WO2022115063A1 PCT/TR2021/050506 TR2021050506W WO2022115063A1 WO 2022115063 A1 WO2022115063 A1 WO 2022115063A1 TR 2021050506 W TR2021050506 W TR 2021050506W WO 2022115063 A1 WO2022115063 A1 WO 2022115063A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- turmeric
- curcumin
- supercritical fluid
- production method
- food supplement
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 244000163122 Curcuma domestica Species 0.000 claims abstract description 43
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 39
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 37
- 235000013976 turmeric Nutrition 0.000 claims abstract description 37
- 239000012530 fluid Substances 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 19
- 244000203593 Piper nigrum Species 0.000 claims abstract description 13
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 13
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 13
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 13
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 13
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 13
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract description 13
- 235000013614 black pepper Nutrition 0.000 claims abstract description 11
- 229930153442 Curcuminoid Natural products 0.000 claims abstract description 9
- 235000013305 food Nutrition 0.000 claims abstract description 8
- 230000002195 synergetic effect Effects 0.000 claims abstract description 8
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 4
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims abstract description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims abstract description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims abstract description 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 81
- 235000012754 curcumin Nutrition 0.000 claims description 40
- 239000004148 curcumin Substances 0.000 claims description 40
- 229940109262 curcumin Drugs 0.000 claims description 40
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 2
- 239000007902 hard capsule Substances 0.000 claims description 2
- 239000007937 lozenge Substances 0.000 claims description 2
- 229940097496 nasal spray Drugs 0.000 claims description 2
- 239000007922 nasal spray Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 1
- 239000007923 nasal drop Substances 0.000 claims 1
- 229940100662 nasal drops Drugs 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 description 16
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 11
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 11
- 235000019100 piperine Nutrition 0.000 description 10
- 229940075559 piperine Drugs 0.000 description 10
- 239000008601 oleoresin Substances 0.000 description 9
- 235000020744 piper nigrum extract Nutrition 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000020240 turmeric extract Nutrition 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 description 4
- NAAJVHHFAXWBOK-UHFFFAOYSA-N (+)-ar-Turmerone Chemical compound CC(C)=CC(=O)CC(C)C1=CC=C(C)C=C1 NAAJVHHFAXWBOK-UHFFFAOYSA-N 0.000 description 3
- UEPVWRDHSPMIAZ-IZTHOABVSA-N (1e,4z,6e)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one Chemical compound C1=C(O)C(OC)=CC(\C=C\C(\O)=C\C(=O)\C=C\C=2C=CC(O)=CC=2)=C1 UEPVWRDHSPMIAZ-IZTHOABVSA-N 0.000 description 3
- HJTVQHVGMGKONQ-LUZURFALSA-N Curcumin II Natural products C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=CC(O)=CC=2)=C1 HJTVQHVGMGKONQ-LUZURFALSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- NMRUIRRIQNAQEB-UHFFFAOYSA-N demethoxycurcumin Natural products OC(=CC(C=CC1=CC(=C(C=C1)O)OC)=O)C=CC1=CC=C(C=C1)O NMRUIRRIQNAQEB-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- UEPVWRDHSPMIAZ-UHFFFAOYSA-N p-hydroxycinnamoyl feruloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(O)=CC(=O)C=CC=2C=CC(O)=CC=2)=C1 UEPVWRDHSPMIAZ-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NAAJVHHFAXWBOK-ZDUSSCGKSA-N (+)-ar-Turmerone Natural products CC(C)=CC(=O)C[C@H](C)C1=CC=C(C)C=C1 NAAJVHHFAXWBOK-ZDUSSCGKSA-N 0.000 description 2
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 2
- 229960004308 acetylcysteine Drugs 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
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- 238000011161 development Methods 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
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- 230000036541 health Effects 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
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- 229920000136 polysorbate Polymers 0.000 description 2
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000015487 sulforaphane Nutrition 0.000 description 2
- 229960005559 sulforaphane Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000018991 trans-resveratrol Nutrition 0.000 description 2
- 239000008513 turmeric extract Substances 0.000 description 2
- 229940052016 turmeric extract Drugs 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- LRDZCBICVMXPBB-UHFFFAOYSA-N β-atlantone Chemical compound CC(C)=CC(=O)CC(=C)C1CCC(C)=CC1 LRDZCBICVMXPBB-UHFFFAOYSA-N 0.000 description 2
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 description 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 description 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 description 1
- XZRVRYFILCSYSP-OAHLLOKOSA-N (-)-beta-bisabolene Chemical compound CC(C)=CCCC(=C)[C@H]1CCC(C)=CC1 XZRVRYFILCSYSP-OAHLLOKOSA-N 0.000 description 1
- XMGQYMWWDOXHJM-SNVBAGLBSA-N (-)-α-limonene Chemical compound CC(=C)[C@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-SNVBAGLBSA-N 0.000 description 1
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 1
- XZRVRYFILCSYSP-HNNXBMFYSA-N (R)-β-bisabolene Chemical compound CC(C)=CCCC(=C)[C@@H]1CCC(C)=CC1 XZRVRYFILCSYSP-HNNXBMFYSA-N 0.000 description 1
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- JIJQKFPGBBEJNF-KBPBESRZSA-N Curlone Natural products CC(C)=CC(=O)C[C@H](C)[C@@H]1CCC(=C)C=C1 JIJQKFPGBBEJNF-KBPBESRZSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 description 1
- XOCANRBEOZQNAQ-KBPBESRZSA-N alpha-turmerone Natural products O=C(/C=C(\C)/C)C[C@H](C)[C@H]1C=CC(C)=CC1 XOCANRBEOZQNAQ-KBPBESRZSA-N 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- XOCANRBEOZQNAQ-KGLIPLIRSA-N ar-turmerone Natural products C[C@H](CC(=O)C=C(C)C)[C@@H]1CC=C(C)C=C1 XOCANRBEOZQNAQ-KGLIPLIRSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- XZRVRYFILCSYSP-UHFFFAOYSA-N beta-Bisabolene Natural products CC(C)=CCCC(=C)C1CCC(C)=CC1 XZRVRYFILCSYSP-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- JYTVKRNTTALBBZ-UHFFFAOYSA-N bis demethoxycurcumin Natural products C1=CC(O)=CC=C1C=CC(=O)CC(=O)C=CC1=CC=CC(O)=C1 JYTVKRNTTALBBZ-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
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- JIJQKFPGBBEJNF-UHFFFAOYSA-N curlone Chemical compound CC(C)=CC(=O)CC(C)C1CCC(=C)C=C1 JIJQKFPGBBEJNF-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
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- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
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- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 230000023611 glucuronidation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000009160 phytotherapy Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001894 piper nigrum l. oleoresin black Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229940124606 potential therapeutic agent Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- KKOXKGNSUHTUBV-UHFFFAOYSA-N racemic zingiberene Natural products CC(C)=CCCC(C)C1CC=C(C)C=C1 KKOXKGNSUHTUBV-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010993 response surface methodology Methods 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 229930006696 sabinene Natural products 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- -1 sorbitan fatty acid ester Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004306 sulfadiazine Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- KKOXKGNSUHTUBV-LSDHHAIUSA-N zingiberene Chemical compound CC(C)=CCC[C@H](C)[C@H]1CC=C(C)C=C1 KKOXKGNSUHTUBV-LSDHHAIUSA-N 0.000 description 1
- 229930001895 zingiberene Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Definitions
- Curcuma longa which belongs to Zingiberaceace family, colloquially known as turmeric, is a yellow-flowered, perennial herbaceous plant that has been consumed for food and treatment for thousands of years.
- the main roots of this plant under the soil are in the form of egg and pear, and the side roots are in the form of tuber. These tubers contain yellow color pigments and are called turmeric.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a food supplement composition developed for use in the manufacture of main pharmaceutical products and the food industry, and the production method thereof. In order to realize this, the inventive food supplement composition contains at least one of the polysorbate 80 or polysorbate 20 as emulsifier the supercritical fluid extract of black pepper and the combination of curcuminoid and turmeric with the synergistic effect of the supercritical fluid extract.
Description
A composition of a food supplement and production method thereof
Technical Field of the Invention
The present invention relates to a food supplement composition developed for use in the manufacture of main pharmaceutical products and the food industry, and the production method thereof.
State of the Art
Curcuma longa which belongs to Zingiberaceace family, colloquially known as turmeric, is a yellow-flowered, perennial herbaceous plant that has been consumed for food and treatment for thousands of years. The main roots of this plant under the soil are in the form of egg and pear, and the side roots are in the form of tuber. These tubers contain yellow color pigments and are called turmeric.
Curcuminoids and oleoresins are obtained from the root (rhizome) sections of the turmeric plant by means of extraction methods. Curcuminoids is a mixture of curcumin, demethoxycurcumin and bisdemetoxycurcumin components. Curcumin is the main component of the curcuminoid mixture, but demethoxycurcumin and bisdemetoxicurcumin are the minor components of the mixture. Oleoresins consist of resin and essential oils. Essential oils or turmeric essential oils are obtained as a byproduct during the extraction of curcuminoids. The main component of the essential oil is ar-turmeron, also known as turmeron. Ar-turmeron constitutes approximately 40-50 % of turmeric essential oil.
Turmeric powder has been used for centuries for general health problems in traditional medicine. However, curcumin obtained from turmeric extraction has poor water solubility, limited gastrointestinal absorption and rapid excretion from the body. These factors prevent the development of curcumin as a potential therapeutic agent in the state of the art.
In literature, studies carried out regarding turmeric essential oils called oleoresin obtained from the root of the turmeric plant have been encountered. Among these studies, there are studies aimed at eliminating potential antidepressive effects and studies on Alzheimer's disease. Furthermore, turmeric essential oils have been reported to have antifungal, antibacterial and antioxidant properties.
The application numbered TR 2019/00120 titled "Food supplement containing curcumin, trans-resveratrol, sulforaphane and bioperin" has been encountered in literature. Herein, a food supplement containing curcumin, trans-resveratrol, sulforaphane, and bioperin, which strengthens the immune system and increases the body's resistance to diseases, is disclosed. Herein, the use of piperine is disclosed so as to increase the bioavailability of curcumin. However, the production of the preparation called "CURCOIL" with increased bioavailability due to the synergistic effect of the supercritical fluid extract of turmeric with curcuminoid is not stated.
Also in the literature, the application numbered WO2013171697A1 titled “A drug or supplement containing an active ingredient with low oral bioavailability” was encountered. The invention here mainly consists of a chitosan salt salted with active ingredient with a low bioavailability, polysorbate and N-acetylcysteine (NAC). Said active substance with low bioavailability may be curcumin. Hereby, chitosan salt is used in addition to polysorbate so as to increase bioavailability However, here the use of the supercritical fluid extract of turmeric is not stated.
As a result, due to the abovementioned disadvantages and the insufficiency of the current solutions regarding the subject matter, a development is required to be made in the relevant technical field.
Brief Description of the Invention
The present invention is related to a composition of a food supplement and production method thereof which fulfills the abovementioned requirements, eliminates all disadvantages and brings some additional advantages.
The main aim of the invention is to develop a food supplement composition that benefits from the synergistic effect of curcumin and turmeric supercritical fluid extract, with increased bioavailability of curcumin in its content and having therapeutic properties.
A similar aim of the invention is to develop a food supplement composition that improves the water solubility of curcumin, gastrointestinal absorption and excretion time from the body and increases the oral bioavailability of curcumin by means of the polysorbate 80 it contains.
A similar aim of the invention is to develop a food supplement composition that increases the bioavailability of curcumin by means of black pepper extract with piperine it contains.
In order to fulfill the aims mentioned above, the inventive food supplement composition contains at least one of the polysorbate 80 or polysorbate 20 as emulsifier the supercritical fluid extract of black pepper and the combination of curcuminoid and turmeric with the synergistic effect of the supercritical fluid extract.
The structural and characteristic features of the present invention will be understood clearly by the following detailed description and therefore the evaluation shall be made by taking the detailed description into consideration.
Detailed Description of the Invention
In this detailed description, the inventive pharmaceutical composition and the production method thereof is described only for clarifying the subject matter in a manner such that no limiting effect is created.
The inventive food supplement composition is mainly obtained by supercritical fluid extract of turmeric and the synergistic effect of the curcuminoids. The inventive food supplement composition contains at least one of the polysorbate 80 or polysorbate 20 as emulsifier and supercritical fluid extract of black pepper as oleoresin. The percentages of the components forming the inventive food supplement composition by weight and their preferred amounts are presented in Table 1 in percent.
Table 1. The percentages of the components forming the inventive food supplement composition by weight
In a preferred embodiment of the inventive food supplement composition, polysorbate 80 is used. Polysorbate 80 is a solvent, dispersing agent and emulsifier widely used in pharmaceutical, food and cosmetic industries. Polysorbate 80 facilitates drug absorption when formulated with active substance and provides active substance stabilization for a long time. Curcumin obtained from turmeric extraction has poor water solubility, low
gastrointestinal absorption and rapid excretion from the body. Accordingly, its oral bioavailability is low. In a preferred embodiment of the inventive food supplement composition, usage of polysorbate 80 improves the absorption of curcumin. Herein, polysorbate 80 forms micelles with curcumin and ensures to increase the bioavailability of curcumin.
Black pepper which is known as a tangy aromatic flavor is the whole or powdered dried fruit of Piper nigrum (black pepper), a vine specific to India and Asia. Black pepper extract consists of oleoresin between 10-15 %, piperine between 40-50 % and other components. The main volatile components in this 10-15 % oleoresin in the black pepper extract obtained by the supercritical fluid extraction method are as follows; 31 -34 % caryophllene, 7-8 % sabinene, 6-7 % beta pinene, 11-13 % limonene, 8-10 % beta bisabolene. In vitro and in vivo studies on piperine, which is the main component of black pepper, have shown that piperine has anti-carcinogenic, immunomodulatory, anti-asthma, liver protective, anti inflammatory properties. In addition to this, it was shown that piperine increases the absorption of the active substances such as curcumin, rifampicin, sulfadiazine, tetracillin, etc. with anti-oxidant and biotransformative effects. For these reasons, black pepper extract containing 40-50 % piperine is used in the inventive food supplement composition. Therefore, the bioavailability of curcumin is increased.
Studies on turmeric essential oils have shown that aromatic-turmerone has various medical and pharmacological properties such as powerful anti-inflammatory, anti-oxidative, anti fungal etc. In addition to these, there are many studies on turmeric essential oils aimed at eliminating potential antidepressive effects and studies on Alzheimer's disease. In the inventive food supplement composition, it is benefited from the synergistic effect of the supercritical fluid extract of curcumin and turmeric. A new product has been developed with the effect of turmeric essential oils that increase the bioavailability of curcumin.
First of all the emulsifier, preferably polysorbate 80, is heated to a temperature between about 50-60 Ό so as to obtain the inventive food s upplement composition. Then, the curcumin powder is slowly added into the emulsifier under stirring. First of all, this mixture is heated to a temperature range between 90-95 °C and kept for 10 minutes between these temperature values. Therefore, the emulsifier forms micelles with curcumin. In this process step, it is important to increase the temperature above 90Ό by adding curcuminoid powder. Subsequently, the mixture is cooled to below 50TT Supercritical fluid extract of turmeric and black pepper extract are added slowly into the cooled mixture under stirring. Herein, it
shall be considered that turmeric and black pepper extracts shall be added after the mixture has cooled down to 5013. The obtained mixture with the addition of turmeric and black pepper extracts is slowly heated up to 70TT This h eated mixture is stirred at a temperature range of 65-75 Ό for 15 minutes. Thus, the preparation called “curcoil" with increased bioavailability are produced with the synergistic effect of the oleoresins and curcuminoids Temperature and time are the points that must be considered for this process. Finally, the mixture is cooled to below 50 TT Thus, the final p roduct obtained is ready for filling. Herein, the filling process shall be carried out below 50 °C. It is possible to produce the obtained final product in various edible or drinkable forms such as tablets, lozenges, pills, hard or soft capsules, throat or nasal spray, drops.
Curcumin which is the yellow pigment of turmeric is produced by using oleoresin of turmeric as an industrial raw material. Main components contain approximately 70-80 % essential and fixed oils, resin and insoluble curcumin compounds after isolation of curcumin from oleoresin.
Many biological target and cellular effects exhibiting anti-inflammatory, antioxidant and immunomodulatory activities have been found in the preclinical studies on turmeric carried out in recent years. In addition to these effects, curcumin has been extensively studied as an anticancer agent, by means of its proven antioxidant and anti-inflammatory activities. Turmeric has been suggested to have numerous health benefits in clinical studies, inflammatory conditions such as rheumatoid arthritis (RA), inflammatory bowel disease, psoriasis. However, it has been determined that curcuminoids are not easily absorbed by the human intestine. Therefore, various methods are developed so as to improve the bioavailability of curcumin. The supercritical fluid extract of turmeric is used so as to increase the bioavailability of curcuminoids in the inventive food supplement composition. Here, the curcuminoids are isolated from turmeric whose oil is extracted with supercritical fluid by way of solvent extraction. Extraction is performed at temperatures between 55-75 ° C. The solvent is partially removed so as to obtain a concentrated solution. This solution is cooled so as to crystallize the curcuminoids that are isolated by an appropriate method such as filtration and/or centrifugation. Analysis results of this product consisting of curcuminoid crystals isolated from turmeric shows that it consists of 75-95 % of the curcumin, the remaining part consists of demethoxycurcumin and bisdemetoksicurcumin.
Essential oils are naturally found in turmeric roots (rhizomes) and are usually used for flavoring and coloring. Essential oils contain molecules with high effects on health such as ar-tumerone, a-tumerone, b-tumerone, b-atlantone etc. Studies that have been carried out
have shown that aromatic-turmerone has powerful anti-inflammatory and anti-oxidative properties. Today, these therapeutic components been used in traditional Chinese medicinal healing systems for a long time, have been confirmed to have positive effects on health, number of times by scientific data. The turmeric extract is obtained with a supercritical fluid extraction system in a manner such that the extractor pressure is between 150-300 bar and the temperature is between 50-90 ° C. As a result of obtained volatile component analysis of turmeric extract, it contains 40-50 % ar-turmerone, 15-20 % curlone, 5-10 % b-atlantone as the main components, it also contains a-tumerone, b-tumerone, zingiberene, a-caryophyllene.
Pharmacokinetic properties of curcumin, following oral administration, most of the same is excreted without being absorbed by the body, it has been observed that it is poorly absorbed with traces only visible in the blood. For this reason, it is necessary to use different auxiliary substances that can block the metabolic pathways of curcumin so as increase the bioavailability of curcumin. It was reported that piperine which is an alkaloid extracted from black pepper inhibits glucuronidation activity in rats and guinea pigs. It was shown that co administration of piperine and curcumin to humans and rats increases the bioavailability of curcumin. The black pepper extract is obtained with a supercritical fluid extraction system in a manner such that the extractor pressure is between 150-300 bar and the temperature is between 50-90 °C. The main component of piperin e is obtained in a ratio between 40- 50 % as a result of the analysis of the obtained black pepper oleoresin. Furthermore, the essential oils obtained contain turmeric volatile components as the main component and also contains caryophyllene in a ratio between 27-35 %, l-Limonene in a ratio between IQ- 15 %, b-bisabolene in a ratio between 5-10 % as well as b -pinene, a-pinene and other terpenes.
Polysorbate 80 is a substance that is formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide. It is commonly used in many countries, including the USA and the EU, as an emulsifier, solvent, dispersing agent in food and pharmaceutical products. It is observed in studies that polysorbate 80 substantially increases the bioavailability of curcumin.
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Claims
1. A food supplement composition comprising at least one of the polysorbate 80 or polysorbate 20 as emulsifier the supercritical fluid extract of black pepper developed for the production of basic pharmaceutical products or for use in the food industry, characterized in comprising the combination obtained by the synergistic effect of the supercritical fluid extract of curcuminoid and turmeric.
2. The food supplement according to claim 1 , characterized in comprising emulsifier in a ratio between 77-97 % by weight, supercritical fluid extract of black pepper in a ratio between 1 -3 % by weight, curcuminoid in a ratio between 1 -10 % by weight and turmeric supercritical fluid extract in a ratio between 1-10 % by weight.
3. The food supplement according to claim 2, characterized in comprising emulsifier in a ratio 86.35 % by weight, supercritical fluid extract of black pepper in a ratio %1 ,15 by weight, curcuminoid in a ratio %6,5 by weight and turmeric supercritical fluid extract in a ratio %6 by weight.
4. The food supplement composition according to claim 1 , characterized in a form of tablets, lozenges, pills, hard or soft capsules, throat or nasal spray or drops.
5. A production method of a food supplement composition according to any of the preceding claims, characterized in comprising the following process steps; a. heating the emulsifier, b. adding curcumin powder into the emulsifier by mixing, c. heating and retaining the mixture, d. cooling the mixture, e. adding the supercritical fluid extracts of turmeric and black pepper into the mixture by stirring f. heating and retaining the mixture, g. cooling the mixture, h. filling.
6. The production method according to claim 5, characterized in that; the temperature is between 50-60 Ό in step “a”.
7. The production method according to claim 5, characterized in that; the temperature is in the range of 90-95 °C and the waiting time is 1 0 minutes in step “c”.
8. The production method according to claim 5, characterized in that; the temperature is in the range of 90-95 °C and the waiting time is 1 0 minutes in step “c”.
9. The production method according to claim 5, characterized in that; the temperature is maximum 50 °C in step “d”.
10. The production method according to claim 5, characterized in that; the temperature is in the range of 65-75 °C and the waiting time is 1 5 minutes in step “f”.
11. The production method according to claim 5, characterized in that; the temperature is maximum 50 °C in step “g”.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011125070A2 (en) * | 2010-04-05 | 2011-10-13 | Benny Antony | Formulation of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof |
| US20160256513A1 (en) * | 2015-03-04 | 2016-09-08 | The Synergy Company of Utah, LLC d/b/a Synergy Production Laboratories | Synergized turmeric |
| WO2018185780A1 (en) * | 2017-04-04 | 2018-10-11 | Olene Life Sciences Private Limited | Bioavailable composition for turmeric oleoresin |
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2021
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011125070A2 (en) * | 2010-04-05 | 2011-10-13 | Benny Antony | Formulation of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof |
| US20160256513A1 (en) * | 2015-03-04 | 2016-09-08 | The Synergy Company of Utah, LLC d/b/a Synergy Production Laboratories | Synergized turmeric |
| WO2018185780A1 (en) * | 2017-04-04 | 2018-10-11 | Olene Life Sciences Private Limited | Bioavailable composition for turmeric oleoresin |
Non-Patent Citations (1)
| Title |
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| SHIYOU LI ET AL: "Chemical composition and product quality control of turmeric (Curcuma longa L.)", PHARMACEUTICAL CROPS, 1 January 2011 (2011-01-01), pages 28 - 54, XP055849011, Retrieved from the Internet <URL:https://core.ac.uk/download/pdf/72733173.pdf> [retrieved on 20211007] * |
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