WO2022112364A3 - Biocompatible composite membrane, method for fabricating the membrane, bioreactor and method for investigating cells attached to the biocompatible composite membrane - Google Patents
Biocompatible composite membrane, method for fabricating the membrane, bioreactor and method for investigating cells attached to the biocompatible composite membrane Download PDFInfo
- Publication number
- WO2022112364A3 WO2022112364A3 PCT/EP2021/082887 EP2021082887W WO2022112364A3 WO 2022112364 A3 WO2022112364 A3 WO 2022112364A3 EP 2021082887 W EP2021082887 W EP 2021082887W WO 2022112364 A3 WO2022112364 A3 WO 2022112364A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- membrane
- composite membrane
- biocompatible composite
- bioreactor
- fabricating
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title abstract 8
- 239000002131 composite material Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000463 material Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
- C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
Abstract
In various embodiments a biocompatible composite membrane for in vitro cell culturing comprising a first material, which is non-water soluble and a water soluble second material is provided, wherein the composite membrane comprises a porous scaffold and a filling layer, the scaffold comprising the first material and the filling layer comprising the second material. Further, a method for fabricating the membrane, a bioreactor for use of the membrane in cell-stretch experiments and a corresponding method for investigating cells attached to the biocompatible composite membrane are also provided.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18/038,393 US20240002898A1 (en) | 2020-11-24 | 2021-11-24 | Biocompatible composite membrane, method for fabricating the membrane, bioreactor and method for investigating cells attached to the biocompatible composite membrane |
EP21827192.2A EP4251727A2 (en) | 2020-11-24 | 2021-11-24 | Biocompatible composite membrane, method for fabricating the membrane, bioreactor and method for investigating cells attached to the biocompatible composite membrane |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LULU102222 | 2020-11-24 | ||
LU102222 | 2020-11-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2022112364A2 WO2022112364A2 (en) | 2022-06-02 |
WO2022112364A3 true WO2022112364A3 (en) | 2022-08-18 |
Family
ID=74186803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2021/082887 WO2022112364A2 (en) | 2020-11-24 | 2021-11-24 | Biocompatible composite membrane, method for fabricating the membrane, bioreactor and method for investigating cells attached to the biocompatible composite membrane |
Country Status (3)
Country | Link |
---|---|
US (1) | US20240002898A1 (en) |
EP (1) | EP4251727A2 (en) |
WO (1) | WO2022112364A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113005036B (en) * | 2021-03-29 | 2023-06-30 | 厦门大学 | Detachable cell culture flow chamber capable of generating turbulence |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070166817A1 (en) * | 2006-01-18 | 2007-07-19 | Kci Licensing, Inc. | System and Method for Applying Reduced Pressure to Cell Culture |
EP2907532A1 (en) * | 2014-02-14 | 2015-08-19 | Han Biomedical Inc. | Method for forming dual-layer composite material, dual-layer composite material thereby, bio-medical equipment containing the dual-layer composite material |
CN104941011A (en) * | 2015-06-09 | 2015-09-30 | 烟台森森环保科技有限公司 | Medical film with cell scaffold for preventing tissue adhesion in medical surgery |
US20170183622A1 (en) * | 2015-12-03 | 2017-06-29 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Biopapers as a substrate for tissue culture |
WO2019199630A1 (en) * | 2018-04-09 | 2019-10-17 | Luna Innovations Incorporated | Nanofiber-reinforced hydrogel medical dressings |
-
2021
- 2021-11-24 WO PCT/EP2021/082887 patent/WO2022112364A2/en unknown
- 2021-11-24 US US18/038,393 patent/US20240002898A1/en active Pending
- 2021-11-24 EP EP21827192.2A patent/EP4251727A2/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070166817A1 (en) * | 2006-01-18 | 2007-07-19 | Kci Licensing, Inc. | System and Method for Applying Reduced Pressure to Cell Culture |
EP2907532A1 (en) * | 2014-02-14 | 2015-08-19 | Han Biomedical Inc. | Method for forming dual-layer composite material, dual-layer composite material thereby, bio-medical equipment containing the dual-layer composite material |
CN104941011A (en) * | 2015-06-09 | 2015-09-30 | 烟台森森环保科技有限公司 | Medical film with cell scaffold for preventing tissue adhesion in medical surgery |
US20170183622A1 (en) * | 2015-12-03 | 2017-06-29 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Biopapers as a substrate for tissue culture |
WO2019199630A1 (en) * | 2018-04-09 | 2019-10-17 | Luna Innovations Incorporated | Nanofiber-reinforced hydrogel medical dressings |
Also Published As
Publication number | Publication date |
---|---|
US20240002898A1 (en) | 2024-01-04 |
WO2022112364A2 (en) | 2022-06-02 |
EP4251727A2 (en) | 2023-10-04 |
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