WO2022103988A3 - Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth - Google Patents

Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth Download PDF

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Publication number
WO2022103988A3
WO2022103988A3 PCT/US2021/059022 US2021059022W WO2022103988A3 WO 2022103988 A3 WO2022103988 A3 WO 2022103988A3 US 2021059022 W US2021059022 W US 2021059022W WO 2022103988 A3 WO2022103988 A3 WO 2022103988A3
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Prior art keywords
prostate cancer
diagnosing
compositions
methods
cell growth
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PCT/US2021/059022
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French (fr)
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WO2022103988A2 (en
Inventor
Daniel G. GIOELI
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University Of Virginia Patent Foundation
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Publication date
Priority claimed from US17/095,511 external-priority patent/US20210071268A1/en
Application filed by University Of Virginia Patent Foundation filed Critical University Of Virginia Patent Foundation
Priority to EP21892828.1A priority Critical patent/EP4232605A2/en
Priority to US18/036,610 priority patent/US20240068037A1/en
Publication of WO2022103988A2 publication Critical patent/WO2022103988A2/en
Publication of WO2022103988A3 publication Critical patent/WO2022103988A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided herein is a previously unannotated IncRNA lying within exon six and 3'UTR of the LCK gene, labeled "HULLK" for Hormone-Upregulated IncRNA within LCK. HULLK is a novel IncRNA situated within the L C K gene that can serve as an oncogene in PCa. Accordingly, provided are methods and compositions for diagnosing and treating prostate cancer based on HULLK that regulates prostate cancer cell growth.
PCT/US2021/059022 2019-08-21 2021-11-11 Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth WO2022103988A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP21892828.1A EP4232605A2 (en) 2020-11-11 2021-11-11 Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth
US18/036,610 US20240068037A1 (en) 2019-08-21 2021-11-11 Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/095,511 2020-11-11
US17/095,511 US20210071268A1 (en) 2019-08-21 2020-11-11 Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth

Publications (2)

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WO2022103988A2 WO2022103988A2 (en) 2022-05-19
WO2022103988A3 true WO2022103988A3 (en) 2022-06-16

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PCT/US2021/059022 WO2022103988A2 (en) 2019-08-21 2021-11-11 Methods and compositions for diagnosing and treating prostate cancer based on long noncoding rna overlapping the lck gene that regulates prostate cancer cell growth

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EP (1) EP4232605A2 (en)
WO (1) WO2022103988A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11788091B2 (en) 2019-08-21 2023-10-17 University Of Virginia Patent Foundation Methods and compositions for diagnosing and treating prostate cancer based on long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100129804A1 (en) * 2006-11-08 2010-05-27 Chinnaiyan Arul M Spink1 as a prostate cancer marker and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100129804A1 (en) * 2006-11-08 2010-05-27 Chinnaiyan Arul M Spink1 as a prostate cancer marker and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TA HUY Q., WHITWORTH HILARY, YIN YI, CONAWAY MARK, FRIERSON HENRY F., CAMPBELL MORAY J., RAJ GANESH V., GIOELI DANIEL: "Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth", MOLECULAR CANCER, vol. 18, no. 1, 1 December 2019 (2019-12-01), XP055940232, DOI: 10.1186/s12943-019-1039-6 *

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WO2022103988A2 (en) 2022-05-19
EP4232605A2 (en) 2023-08-30

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