WO2022093212A1 - Dispositifs de dosage à effet de mèche automatique - Google Patents

Dispositifs de dosage à effet de mèche automatique Download PDF

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Publication number
WO2022093212A1
WO2022093212A1 PCT/US2020/057663 US2020057663W WO2022093212A1 WO 2022093212 A1 WO2022093212 A1 WO 2022093212A1 US 2020057663 W US2020057663 W US 2020057663W WO 2022093212 A1 WO2022093212 A1 WO 2022093212A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
complexing
region
analyte
binding
Prior art date
Application number
PCT/US2020/057663
Other languages
English (en)
Inventor
Beverly CHOU
Adam WEISMAN
Tynan BECKER
Original Assignee
Hewlett-Packard Development Company, L.P.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hewlett-Packard Development Company, L.P. filed Critical Hewlett-Packard Development Company, L.P.
Priority to PCT/US2020/057663 priority Critical patent/WO2022093212A1/fr
Publication of WO2022093212A1 publication Critical patent/WO2022093212A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/009—After-treatment of organic or inorganic membranes with wave-energy, particle-radiation or plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/48—Polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/02—Hydrophilization
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/36—Introduction of specific chemical groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/36—Hydrophilic membranes

Definitions

  • the multiple regions can include a complexing region 120 with an analyte-complexing compound 142 applied thereto that may have a functional group for binding with an analyte introduced with a sample fluid (not shown but shown at FIG.2).
  • the detecting region 150 in this example includes the same hydrophilic porous substrate as is present at the complexing region, but in this example, the detecting region is modified with a binding promoter 162.
  • FIGS.3 and 4 Systems for manufacturing a self-wicking assay device are show by way of Example in FIGS.3 and 4.
  • the system is shown in the context of an example where various fluids or “agents” can be digitally controlled by ejection from fluidjet printheads, for example.
  • a binding agent 160 can be applied to a detecting region 150 of hydrophilic porous substrate 110, followed by application of a testing agent 170 to a first discrete location of the detecting region as well as a control agent 180 to a second discrete location of the detecting region.
  • Application (A) can occur before application (B) and application (C) which may be applied together or in either order.
  • the binding promoter that is applied can be covalently attached to the hydrophilic porous substrate, and furthermore, the testing compound and/or the control compound can be applied to covalently attach thereto or alternatively can be applied to interact by electrostatic attraction, hydrogen bonding, hydrophobic interaction, or the like, without covalent attachment.
  • the binding promoter may be a surface chemistry modification of the substrate. Modification of the surface chemistry can be by any methodology, but in one example, surface chemistry modification can occur by plasma treatment. Polyester in particular is a material that can be treated with plasma to break ester bonds to generate a surface with a more negative charge.
  • numeric range that ranges from about 10 to about 500 should be interpreted to include the explicitly recited sub-range of about 10 to about 500 as well as sub-ranges thereof such as about 50 and about 300, as well as sub- ranges such as from about 100 to about 400, from about 150 to about 450, from about 25 to about 250, etc.

Abstract

Des dispositifs de dosage à effet de mèche automatique peuvent comprendre un substrat poreux hydrophile pour un écoulement de fluide d'échantillon séquentiel d'une région de complexation à une région de détection de celui-ci. La région de complexation peut comprendre un composé de complexation d'analyte sur le substrat poreux hydrophile, et la région de détection peut être positionnée en aval de la région de complexation le long du substrat poreux hydrophile. Un promoteur de liaison peut être appliqué à la région de détection du substrat poreux hydrophile, un composé de test immobilisé peut être appliqué au promoteur de liaison à un premier emplacement discret de la région de détection, et un composé de commande immobilisé peut être appliqué au promoteur de liaison à un second emplacement discret de la région de détection.
PCT/US2020/057663 2020-10-28 2020-10-28 Dispositifs de dosage à effet de mèche automatique WO2022093212A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2020/057663 WO2022093212A1 (fr) 2020-10-28 2020-10-28 Dispositifs de dosage à effet de mèche automatique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2020/057663 WO2022093212A1 (fr) 2020-10-28 2020-10-28 Dispositifs de dosage à effet de mèche automatique

Publications (1)

Publication Number Publication Date
WO2022093212A1 true WO2022093212A1 (fr) 2022-05-05

Family

ID=81383014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/057663 WO2022093212A1 (fr) 2020-10-28 2020-10-28 Dispositifs de dosage à effet de mèche automatique

Country Status (1)

Country Link
WO (1) WO2022093212A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007891A2 (fr) * 1999-07-27 2001-02-01 Cellomics, Inc. Procedes et appareil de jeu ordonne miniaturise de cellules destines au criblage cellulaire
WO2001055701A1 (fr) * 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System Systeme et procede d'analyse des fluides corporels
AU2012211141A1 (en) * 2011-01-27 2013-08-22 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007891A2 (fr) * 1999-07-27 2001-02-01 Cellomics, Inc. Procedes et appareil de jeu ordonne miniaturise de cellules destines au criblage cellulaire
WO2001055701A1 (fr) * 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System Systeme et procede d'analyse des fluides corporels
US20040053322A1 (en) * 2000-01-31 2004-03-18 Mcdevitt John T. System and method for the analysis of bodily fluids
AU2012211141A1 (en) * 2011-01-27 2013-08-22 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof

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