WO2022076405A1 - Appareil et procédé de réduction de symptômes de troubles neurologiques du mouvement à l'aide d'un dispositif pouvant être porté - Google Patents

Appareil et procédé de réduction de symptômes de troubles neurologiques du mouvement à l'aide d'un dispositif pouvant être porté Download PDF

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WO2022076405A1
WO2022076405A1 PCT/US2021/053561 US2021053561W WO2022076405A1 WO 2022076405 A1 WO2022076405 A1 WO 2022076405A1 US 2021053561 W US2021053561 W US 2021053561W WO 2022076405 A1 WO2022076405 A1 WO 2022076405A1
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Prior art keywords
body part
movement
data
stimulation
movement disorder
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PCT/US2021/053561
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English (en)
Inventor
Daniel Carballo
Kyle Pina
Allison Davanzo
Trang Luu
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Encora, Inc.
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Priority claimed from US17/063,363 external-priority patent/US11701293B2/en
Application filed by Encora, Inc. filed Critical Encora, Inc.
Priority to JP2023521086A priority Critical patent/JP2023544609A/ja
Priority to CA3194995A priority patent/CA3194995A1/fr
Priority to EP21801735.8A priority patent/EP4225139A1/fr
Priority to AU2021358730A priority patent/AU2021358730A1/en
Publication of WO2022076405A1 publication Critical patent/WO2022076405A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1101—Detecting tremor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/112—Gait analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A61B5/7214—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/726—Details of waveform analysis characterised by using transforms using Wavelet transforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0487—Special user inputs or interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A61B5/395—Details of stimulation, e.g. nerve stimulation to elicit EMG response

Definitions

  • the present invention relates to wearable medical devices and in particular to wearable medical devices that mitigate symptoms of neurological movement disorders.
  • Essential tremor is characterized by tremor of the extremities. Parkinson’s Disease (PD) can cause tremor, rigidity, bradykinesia, and temporary freezing or inability to begin a motion. Restless Leg Syndrome does not cause a tremor; however, it causes a strong compulsion to move and shake the patient’s legs. Tremor can also be present as a side effect of certain medications.
  • Parkinson’s Disease There are approximately 10 million people living with Parkinson’s Disease (PD) in the world today, and over 70% of these patients experience tremors - the involuntary trembling or shaking of the extremities. Other symptoms of PD include stiffness or rigidity of the muscles, bradykinesia (defined as slowness of movement), and freezing (defined as the temporary, involuntary inability to move).
  • Parkinson’s Disease has no cure. Treatments at the moment consist of medications to address patients’ symptoms, though these do not reverse the effects of the disease. Patients often take a variety of medications at different doses and different times of day to manage symptoms.
  • PD medications are most often dopaminergic, either supplying or mimicking the effects of dopamine to replenish the depleted dopamine state caused by the disease.
  • Surgical procedures can be prescribed for patients who have exhausted other medical treatment options.
  • the first method of surgical treatment is Deep Brain Stimulation (DBS).
  • DBS Deep Brain Stimulation
  • electrodes are inserted into the brain, and then an impulse generator battery is implanted under the collar bone or in the abdomen.
  • the patient uses a controller to power the device on or off, as needed, to help control tremors.
  • DBS can be effective for both Parkinson’s disease and essential tremor, but this procedure is invasive and expensive.
  • the second surgical procedure available for Parkinson’s patients is Duopa therapy.
  • Duopa therapy requires a small hole (a stoma) to be surgically made in the stomach to place a tube in the intestine.
  • Duopa which is similar to normal PD medications taken through pills, is then pumped directly into the intestine, which improves absorption and reduces off-times of medications taken by pill.
  • a similar disorder, called essential tremor is often misdiagnosed as Parkinson’s but has an even higher incidence rate with an estimated 100 million cases worldwide. These tremors often occur during intentional movement and can get bad enough that patients no longer have the ability to cut their food, tie their shoes, or sign their name.
  • Essential tremor medications can include beta blockers and anti-seizure medications. These medications are known to cause fatigue, heart problems, and nausea.
  • MS Multiple Sclerosis
  • MS is an inflammatory autoimmune disease of the central nervous system, which affects an estimated 2.8 million people globally. Motor symptoms include weakness or fatigue, gait difficulties, stiffness or spasticity, and tremor. Most people experience what is called a “relapsing-remitting” disease course, which involves periods of new symptoms or relapses, followed by periods of recovery. As the disease progresses, symptom occurrence may take on a regular pattern, after which the disease is classified as “secondary-progressive”. Some MS patients may experience a gradual onset and progression without any relapse-remittance, which is classified as “primary-progressive”. There is no cure for MS, and treatment typically focuses on recovery from relapse attacks using physical therapy and medication.
  • RLS Restless Leg Syndrome
  • RLS is characterized by unpleasant tingling sensations in the patient’s legs. These sensations occur when the legs are still and are alleviated when the legs are in motion. As a result, RLS patients are compelled to move or shake their legs. This is particularly detrimental to the quality of patients’ sleep as they are unable to remain still.
  • RLS is commonly treated by dietary changes, medications, and/or physical therapy. Dietary changes can include eliminating caffeine, alcohol, and tobacco.
  • Medications prescribed for RLS can include the same type of medications prescribed for Parkinson’s Disease (such as dopamine agonists and carbidopa-levodopa) and benzodiazepines (such as lorazepam, Xanax, Valium, and Ativan).
  • Physical therapy for RLS can include massaging the legs or electrical or vibrational stimulation.
  • One example of a device that uses vibration to treat RLS is described in “Systems, devices, and methods for treating restless leg syndrome and periodic limb movement disorder,” Walter, T. J., & Marar, U. (2010), U.S. Patent Application Publication No. US20100249637A1.
  • This device is a lower leg sleeve with sensors and actuators, but it does not store or transmit data, nor does it address any of the other symptoms common to neurological movement disorders.
  • an injection-based Botox treatment for more severe tremors which costs tens of thousands of dollars annually and works by killing the nerves responsible for the tremors.
  • a wearable device for modulating a set of movement disorder symptoms of a subject.
  • the device includes a housing and an attachment system, configured to be attached to a body part of a subject.
  • the device further includes a set of body part sensors to provide a set of sensor outputs related to movement of the body part, and a set of mechanical transducers, coupled to the attachment system, configured to provide a set of mechanical outputs to the body part.
  • the device also includes a processing unit having (i) an input operationally coupled to sensor outputs to receive body part movement data; (ii) noise filtration processing to remove, from the body part movement data, noise unrelated to the movement disorder symptoms so as to produce a filtered movement signal; (iii) feature extraction processing of the filtered movement signal to characterize features of the filtered movement signal so as to produce a characterized filtered movement signal; and (iv) stimulation processing of the characterized filtered movement signal to produce a stimulation signal output, such output being operationally coupled to the set of mechanical transducers, causing the transducers to provide, to the body part, mechanical stimulation that mitigates the set of movement disorder symptoms.
  • a processing unit having (i) an input operationally coupled to sensor outputs to receive body part movement data; (ii) noise filtration processing to remove, from the body part movement data, noise unrelated to the movement disorder symptoms so as to produce a filtered movement signal; (iii) feature extraction processing of the filtered movement signal to characterize features of the filtered movement signal so
  • the processing unit is further configured to provide active noise cancellation by (a) transforming body part movement data in the time domain into frequency domain data, (b) using the frequency domain data to determine a fundamental frequency of the movement disorder symptoms, (c) generating the stimulation signal output, based on the body part movement data, having a desired phase shift, relative to a phase of the body part movement data at the fundamental frequency.
  • the processing unit is further configured to provide, at the simulation signal output, a train of stimulation signals, each signal in the train having a distinct set of parameters associated with mitigating the set of movement disorder symptoms and wherein the feature extraction processing includes determining displacement or power data associated with the movement of the body part, and the processing unit is also configured to use the displacement or power data to determine which stimulation signal in the train has the greatest mitigation effect.
  • the processing unit is further configured to select the stimulation signal determined to have the greatest mitigation effect for continuous output to the transducers.
  • the set of movement disorder symptoms is selected from the group consisting of tremor, rigidity, bradykinesia, dyskinesia, compulsion to move, and combinations thereof.
  • the processing unit is further configured to detect a freezing gait of a patient with Parkinson’s Disease.
  • the processing unit is further configured to control the set of mechanical transducers so as to mitigate the freezing gait of the patient with Parkinson’s Disease by controlling the set of mechanical transducers.
  • the processing unit is configured to operate in two modes, a first mode in which it is configured to monitor patient movements passively to detect a movement disorder symptom above a threshold and a second mode in which, following detection of such a movement disorder symptom, the processor is configured to enter into active mitigation of the movement disorder symptom.
  • the attachment system includes a wristband, and the set of mechanical transducers are distributed throughout the circumference of the wristband.
  • the device is operated by a button on a face of the device, and the button is configured on the face to allow for ease of use by a patient whose fine motor control is affected by a neurological movement disorder.
  • the wristband is configured with a hook-and-loop fastener, such that the wristband can be fastened with a single hand for ease of use by those whose fine motor control is affected by a neurological movement disorder.
  • the wristband is configured to be expandable via elastic deformation for ease of use by those whose fine motor control is affected by a neurological movement disorder.
  • the device further includes a battery, disposed in the housing, and a magnetic connector coupled to the battery and mounted in the housing for coupling to a mating connector for an external charger, so that the battery can be conveniently configured for charging by a patient lacking fine motor control.
  • the processing unit is further configured to store the body part movement data in memory coupled to the processing unit.
  • the active noise cancellation processor is configured to transform the sensor output into the frequency data by applying a Fourier Transform to the sensor output.
  • the active noise cancellation processor is configured to: (i) select the fundamental frequency by applying an argmax function to the transformed sensor output and (ii) use a bandpass filter to remove, from the stimulation signal, a set of frequency data outside a specified range associated with the fundamental frequency.
  • the set of body part sensors includes an inertial motion unit (IMU) configured to calculate data representing the body part’s acceleration
  • the active noise cancellation processor is further configured to: transform the body part’s acceleration data to the frequency data by applying a Fourier Transform; extract peak frequencies of the body part’s acceleration data from the frequency data; select a window size of the body part’s acceleration data based on the peak frequencies; and capture a portion of the sensor output based on the selected window size and invert the captured portion to generate the stimulation signal.
  • the active noise cancellation processor is configured to select the window size by inverting a lowest of the peak frequencies and converting the inverted lowest of the peak frequencies into a time domain.
  • the active noise cancellation processor is configured to set the window size to a fixed value.
  • a method for mitigating a set of movement disorder symptoms of a subject. The method includes sensing movement of a body part of the subject to provide a set of sensor outputs related to movement of the body part. The method also includes processing the sensor outputs to produce a stimulation signal for mitigating the set of movement disorder symptoms. The processing includes filtering the sensor outputs to remove noise unrelated to the movement disorder symptoms so as to produce a filtered signal.
  • the processing also includes actively processing the filtered signal to (a) transform the sensor outputs into frequency data, (b) use the frequency data to determine a fundamental frequency of the movement disorder symptoms, (c) generate the stimulation signal by processing the sensor outputs based on the fundamental frequency; and (d) apply, to the stimulation signal, a time delay calculated based on the fundamental frequency.
  • the method further includes inputting the stimulation signal to a set of mechanical transducers coupled to the body part so as to mitigate the set of movement disorder symptoms.
  • the processing unit includes a fixed frequency processor, configured to (a) input a set of stimulation signals in succession to the set of mechanical transducers, wherein the set of stimulation signals vary in frequency, (b) transform the sensor outputs into displacement or power data, (c) use the displacement or power data to determine which stimulation signal results in the lowest displacement, and (d) transmit said stimulation signal to the set of mechanical transducers.
  • the processing unit is configured to take input from a user, and use that input to control the stimulation signal.
  • the set of movement disorder symptoms is selected from the group consisting of tremor, rigidity, bradykinesia, dyskinesia, compulsion to move, and combinations thereof.
  • sensing movement of a body part includes operating in two modes, a first mode that monitors patent movements passively to detect a movement disorder symptom above a threshold and a second mode that, following detection of such a movement disorder symptom, enters into active mitigation of the movement disorder symptom.
  • actively processing the filtered signal to transform the sensor outputs into frequency data includes applying a Fourier Transform to the sensor output.
  • actively processing the filtered signal to transform the sensor outputs into frequency data includes: (i) selecting the fundamental frequency by applying an argmax function to the transformed sensor output and (ii) using a bandpass filter to remove, from the stimulation signal, a set of frequency data outside a specified range associated with the fundamental frequency.
  • processing the sensor outputs to produce the stimulation signal further include calculating data representing the body part’s acceleration; transforming body part’s acceleration data to the frequency data by applying a Fourier Transform; extracting peak frequencies of the body part’s acceleration data from the frequency data; selecting a window size of the body part’s acceleration data based on the peak frequencies; and capturing a portion of the sensor output based on the selected window size and inverting the captured portion to generate the stimulation signal.
  • selecting the window size includes inverting a lowest of the peak frequencies and converting the inverted lowest of the peak frequencies into a time domain.
  • selecting the window size includes setting the window size to a fixed value.
  • a method for mitigating a set of movement disorder symptoms of a subject including the steps of monitoring sensor outputs of sensors configured to sense movement of a body part of the subject to provide a set of sensor outputs related to movement of the body part, processing the sensor outputs to produce a stimulation signal for mitigating the set of movement disorder symptoms by filtering the sensor outputs to remove noise unrelated to the movement disorder symptoms so as to produce a filtered signal, using a fixed frequency processor configured to (a) input a set of stimulation signals in succession to the set of mechanical transducers, wherein the set of stimulation signals vary in frequency, (b) transform the sensor outputs into displacement or power data, (c) output the stimulation signal resulting in the greatest mitigation effect.
  • a method is provided of diagnosing a movement disorder in a patient according to the steps of: (1) using a processor to provide, to a set of mechanical transducers, an output of a train of stimulation signals, successively varying in stimulation parameters, in order to induce symptoms of a movement disorder; (2) receiving body part movement data, related to the movement of the body part, from a set of body part sensors; (3) filtering the body part movement data to remove noise unrelated to the movement disorder symptoms so as to produce a filtered signal; and (4) actively processing the filtered signal to (a) transform the sensor outputs into frequency data, (b) use the frequency data to determine a fundamental frequency of the movement of the body part; and (5) further processing the frequency data to determine a probability that the
  • Fig.1 illustrates a system for mitigating movement disorder in accordance with an embodiment of the present invention.
  • Fig.2 is an electrical diagram highlighting the main sub-circuits of the system in Fig.1.
  • Fig.3 is an isometric view of a wearable device in accordance with an embodiment of the present invention.
  • Fig.4 is an exploded isometric view of a wearable device, in which the vibration motors are housed in the band rather than in the main electronics housing, in accordance with an embodiment of the present invention.
  • Fig.5 is an isometric view of a wearable device, in which the device includes a loop mechanism to allow single handed adjustment of the band on the user’s wrist, in accordance with an embodiment of the present invention.
  • Fig.6 shows an embodiment of the present invention worn on a hand viewed from above.
  • Fig.7 shows an embodiment of the present invention worn on a hand viewed from the side.
  • Fig.8 shows a testing configuration for the wearable medical device, which may be used for more rigorous data collection, in accordance with an embodiment of the present invention.
  • Fig.9 illustrates a wearable device for mitigating movement disorder, in which the device is an accessory to a third-party smartwatch or other wearable computing device, in accordance with an embodiment of the present invention.
  • Fig.10 shows a side view of a wearable device, which is as an accessory band for a third-party smartwatch or other wearable computing device, in accordance with an embodiment of the present invention.
  • Fig.11 shows a process by which a raw sensor input is used to compute a set of stimulation parameters, in accordance with an embodiment of the present invention.
  • Fig.12 shows a feature extraction process, in accordance with an embodiment of the present invention.
  • Fig.13 shows a stimulation optimization algorithm, in accordance with an embodiment the present invention.
  • Fig.14 shows a neurological signal cancelling system, illustrating how the wearable device and body interact, in accordance with an embodiment of the present invention.
  • Fig.15 shows a process in which the raw sensor input may be processed using active noise cancellation to compute a set of stimulation parameters, in accordance with an embodiment of the present invention.
  • Fig.16 shows one exemplary embodiment of the process of anti-tremor stimulation signal generation by the active noise cancellation (ANC) processor.
  • Fig 17 shows another exemplary embodiment of the process of anti-tremor stimulation signal generation by the ANC processor.
  • Fig.18 is a pair of renderings by a Parkinson’s patient of a spiral under conditions without and with treatment by a device in accordance with an embodiment of the present invention.
  • Fig.19 illustrates an embodiment of a simple non-convex gradient descent optimization used in embodiment of the present invention for symptom reduction by searching over the parameter configuration space.
  • Fig.20 shows a power spectral density (PSD) plot of the postural tremor of a Parkinson’s Disease patient with and without the use of a device in accordance with an embodiment of the present invention.
  • PSD power spectral density
  • Fig.21 shows a power spectral density (PSD) plot of the postural tremor of an Essential Tremor patient with and without the use of a device in accordance with an embodiment of the present invention.
  • Fig.22 shows the tremor response of 21 PD patients in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the phase rotation of the stimulation, and selecting the phase rotation which results in the greatest tremor mitigation.
  • Fig.23 shows the tremor response of 8 ET patients in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the phase rotation of the stimulation, and selecting the phase rotation which results in the greatest tremor mitigation.
  • Fig.24 shows the tremor response of 19 PD patients in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the frequency of the stimulation, and selecting the frequency which results in the greatest tremor mitigation.
  • Fig.25 shows the tremor response of 6 ET patients in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the frequency of the stimulation, and selecting the frequency which results in the greatest tremor mitigation.
  • a “body part” is a part of a human body, such as a limb (examples of which include an arm, a leg, an ankle, and a wrist) or the neck.
  • a “body part sensor” is a sensor responsive to a parameter, associated with a body part, the parameter selected from the group consisting of force, motion, position, EMG signal directed to a set of muscles of the body part and combinations thereof.
  • a “mechanical transducer” is a device having an electrical input and a mechanical output configured to provide physical stimulation to a subject.
  • a “movement disorder sensor” is a sensor that is configured to provide a measurement associated with a neurological movement disorder.
  • An “attachment system” is a system or a device having a means to mechanically affix component subsystems to the user’s person.
  • a “housing” is a primary enclosed casing which contains one or more component subsystems.
  • a “band” is a flexible segment of material which encircles a body part or portion of a body part for the purpose of affixation thereto and which material may also house one or more component subsystems.
  • the term “vibrational stimulus” refers to a vibration or series of vibrations produced by a vibration motor or group of vibration motors embedded in the device. These vibrations are used to stimulate a response from the targeted proprioceptors in the user’s body.
  • stimulation pattern refers to a vibrational stimulus which is characterized by a number of parameters including frequency, amplitude, and waveform.
  • a “stimulation pattern” can also refer to a longer time scale behavior over which the above- mentioned parameters evolve over time.
  • proprioception refers to the sense of the position of one’s own limbs or body parts and the intensity of force being applied through that body part.
  • a proprioceptor is a sensory neuron which is used for proprioception. There are two types of proprioceptors: “muscle spindles” which are located in the muscle and the “Golgi tendon organs” which are located in the tendons.
  • neurological movement disorder refers to any of the neurological conditions that cause abnormally increased or decreased movements which may be voluntary or involuntary. These include but are not limited to: Ataxia, cervical dystonia, chorea, dystonia, functional movement disorder, Huntington's disease, multiple system atrophy (MSA), paresis, hemiparesis, quadriparesis, post-stroke movement disorders, myoclonus, Parkinson's disease (PD), Parkinsonism, drug induced Parkinsonism (DIP), progressive supranuclear palsy (PSP), restless legs syndrome (RLS), tardive dyskinesia, Tourette syndrome, spasticity, rigidity, bradykinesia, tremor, essential tremor (ET), alcohol or drug withdrawal induced tremor, drug induced tremor, psychogenic tremor, rest tremor, action tremor, cerebellar lesion, rubral tremor, isometric tremor, task-specific tremor, orthostatic tremor, and others.
  • training period refers to a period or phase of the device’s operation during which the device is conducting experimentation or collecting and analyzing data for the purpose of deducing the optimal stimulation pattern.
  • a “computer process” is the performance of a described function in a computer system using computer hardware (such as a processor, field-programmable gate array or other electronic combinatorial logic, or similar device), which may be operating under control of software or firmware or a combination of any of these or operating outside control of any of the foregoing. All or part of the described function may be performed by active or passive electronic components, such as transistors or resistors.
  • a computer process we do not necessarily require a schedulable entity, or operation of a computer program or a part thereof, although, in some embodiments, a computer process may be implemented by such a schedulable entity, or operation of a computer program or a part thereof. Furthermore, unless the context otherwise requires, a “process” may be implemented using more than one processor or more than one (single- or multi-processor) computer. [0074] Wearable Treatment Device.
  • the present invention is directed generally towards wearable medical devices and in particular towards the mitigation of tremors, rigidity, bradykinesia, involuntary rhythmic movements, and freezing associated with neurological movement disorders through mechanical vibrational stimulation of the tendon bundles in the wrist and autonomous sensing, feedback, and adjustment.
  • tremors rigidity
  • bradykinesia rigidity
  • involuntary rhythmic movements and freezing associated with neurological movement disorders
  • Embodiments of the present invention include systems and methods of treating symptoms of neurological movement disorders by stimulating proprioceptors.
  • the systems are wearable devices.
  • the systems and methods can be used for any neurological movement disorder, including but not limited to Parkinson’s Disease, Essential Tremor, post-stroke movement disorders, or restless leg syndrome.
  • the symptoms treated include tremor, rigidity, bradykinesia, stiffness, hemiparesis, and freezing.
  • the symptoms treated include muscle contraction caused by dystonia.
  • the symptoms treated include the inability to locate one’s limbs in space.
  • the proprioceptors targeted for stimulation are located in the wrist.
  • the proprioceptors targeted for stimulation are located in the ankle.
  • the proprioceptors targeted for stimulation are located in the neck.
  • the systems provide stimulus to the proprioceptive nerves (proprioceptors) for reducing symptoms by the use of vibration motors positioned around the surface of the wrist.
  • the systems cycle through frequency patterns and waveforms of stimulation to find the pattern that results in the greatest reduction of movement disorder symptoms.
  • the systems use random white- noise subthreshold stimulation in order to leverage the effect of sensory stochastic resonance.
  • the systems are coupled to one or more sensors that measure the user’s tremor for each of a set of possible stimulation patterns, and the systems assign the pattern of stimulation that relates to the biggest measured decrease in tremor amplitude of that user relative to the tremor exhibited in the absence of stimulation
  • the device finds (learns) the optimal stimulation parameters for use in reducing the symptoms by using sensor-based optimization, including but not limited to model free reinforcement learning, genetic algorithms, Q-learning. These parameters can include any quantities used to define a stimulation waveform such as frequency, amplitude, phase, duty cycle, etc. In some embodiments, these learned parameters also describe the longer time scale behavior of the stimulation pattern evolving over time.
  • the device determines the optimal stimulation as the weighted average of the optimal stimulations for each of the independent symptoms observed where the weights are proportional to the symptom severity relative to the other observed symptoms. For example, if the patient experienced tremors and rigidity, and the severity of the tremors was double that of the rigidity, the output stimulation would be two times the optimal tremor reducing pattern superposed with one times the optimal rigidity reducing pattern. In some embodiments, the device senses all of the active symptoms and elects to reduce only the symptom with the worst severity.
  • the device via sensors, measures the shaking due to RLS of the user and assigns the pattern that relates to the biggest decrease in shaking amplitude of that user where the amplitude is that of the sensor signal and the difference is defined relative to the amplitude observed in the absence of stimulation from the device.
  • the sensors coupled to the device are a combination of accelerometers, gyroscopes, IMUs, or other motion-based sensors.
  • the sensors coupled to the device also include electromyography (EMG) sensors to monitor muscle activation in order to sense tremor severity, rigidity, or movement due to RLS.
  • EMG electromyography
  • the device collects data on the characteristics of the user’s symptoms, such as motion amplitude and frequency or muscle activity with sensors contained in the device such as an accelerometer, pressure sensors, force sensors, gyroscope, Inertial Measurement Unit (IMU), or electromyography (EMG) sensors.
  • sensors contained in the device such as an accelerometer, pressure sensors, force sensors, gyroscope, Inertial Measurement Unit (IMU), or electromyography (EMG) sensors.
  • the above-mentioned data would be stored through storage components contained within the device.
  • the above-mentioned data is regularly consolidated for the purpose of larger scale data analysis through a wired or wireless transfer of data to a larger storage location not on the device.
  • the actuators are resistive heating elements rather than vibration motors.
  • the actuators are vibration motors.
  • the actuators are electromagnets -. In some embodiments, the actuators are electropermanent magnets. In some embodiments, the actuators are piezoelectric actuators. In some embodiments, the actuators are voice coil vibration motors. In some embodiments, the actuators are rotating eccentric mass vibration motors. In some embodiments, the device is an accessory band to a third-party smartwatch or other wearable computing device. In some embodiments, the device can connect wirelessly (for example via Bluetooth) to the user’s smartphone. In some embodiments, the device can be configured to provide contextualized data about the user’s condition. For example, the system can correlate symptom onset or degree with time of day, activity level, medication, diet, other symptoms, etc.
  • this can be accomplished by transmitting extracted sensor signal features to the user’s smartphone.
  • An accompanying smartphone application can periodically prompt the user to input other information like activity level, diet, and medication. The application then logs this data with time matched symptom sensor signal features to be reviewed by the user and/or their physician.
  • the device can be started by passive sensing of the onset of symptoms such as the on/off phenomenon of Parkinson’s patients taking L-dopa. In some embodiments, this can be accomplished by continuously reading sensor data, even while in the “off” state, and then switching to the “on” state when one of the sensor data features, such as amplitude, surpasses a preset threshold value.
  • the device can be used to amplify an existing but subtle tremor for the purpose of early diagnosis. In some embodiments, this can be accomplished by manually testing a set of stimulation patterns until the tremor is apparent, either visually or as detected by an extracted feature of the sensor data surpassing some preset threshold. In some embodiments, this can be accomplished autonomously by inverting the stimulation selection algorithm heuristic such that it converges to the stimulation pattern which maximizes tremor amplitude as measured by the symptom sensor relative to the tremor amplitude measured in the absence of stimulation from the device. [0081] Fig.1 illustrates a system for mitigating movement disorder in accordance with an embodiment of the present invention.
  • the wearable device 11 and user’s body 12 act as a system with inputs and outputs which may be manipulated to change the desired outcome of the system.
  • the wearable device 11 interfaces with a user’s body 12.
  • the user’s body 12 includes proprioceptive nerves 1201, perceived limb position and motion 1202, a nervous system 1203, desired activation control signal 1204, and muscles 1205.
  • the muscles 1205 output electrical activity 1206, which is detected by the EMG sensor 1107 in the wearable’s sensor suite 1106, and collected as local data 1103.
  • the muscles 1205 also output motion 1207, which is detected by the inertial measurement unit (IMU) 1108.
  • the IMU 1108 measures the body’s specific force, angular rate, and orientation, and reports to the processing unit 1101.
  • the processing unit 1101 receives the local data 1103 and executes a local algorithm 1102. Using the local data 1103, the processing unit 110, based on results of the local algorithm 1102, instructs the mechanical transducers 1105 to deliver a specific vibrational stimulus 13.
  • the proprioceptive nerves 1201 detect the vibrational stimulus 13 and send the perceived limb position and motion 1202 to the nervous system 1203. Based on that signal, the nervous system 1203 sends a desired activation control signal 1204 to activate the muscles 1205 in a way that either alters or perpetuates their electrical activity 1206 and motion 1207.
  • the local data 1103 collected by the sensor suite 1106 continues to be processed by the local algorithm 1102, and continues to affect the output of the mechanical transducers 1105.
  • the local data 1103 is also transmitted via the communication module 1104 to a remote processing algorithm 14, and to a remote database 16 for long-term data storage and access by researcher 17, patients 18, or physicians 19.
  • the remote database 16 also receives data from the greater population, or the crowd 15, and sends this data to the remote processing algorithm 14.
  • the remote processing algorithm 14 analyzes the data and returns the results of the analysis both to the processing unit 1101, via the communication module 1104, and also to the crowd 15. In this way, data from the crowd 15 may influence the way that the local algorithm 1102 operates.
  • the processing unit 1101 is configured to operate in two modes, a first mode in which it is configured to monitor patient movements passively to detect a movement disorder above a threshold and a second mode in which, following detection of such a movement disorder, the processor is configured to enter into active mitigation of the movement disorder.
  • processing unit 1101 enters into active mitigation by passive sensing of the onset of symptoms, such as the on/off phenomenon of Parkinson’s patients taking L-dopa.
  • passive sensing is performed by continuously reading sensor data, even while in the “off” state, and then switching to the “on” state when one of the sensor data features, such as amplitude, surpasses a preset threshold value.
  • Fig.2 is an electrical diagram highlighting the main sub-circuits of the system in Fig.1.
  • Fig.2 shows the processing unit 1101, which receives body part motional data (e.g. tremor vibration data) from the inertial measurement unit 1108 in the IMU circuit 22. This data is used by the processing unit 1101 to drive the mechanical transducers 1105 in the mechanical transducer circuit 23 at various frequencies and amplitudes.
  • the processing unit 1101 may also receive muscle activity data from the electromyography (EMG) sensors 1107 in the EMG circuit 24.
  • EMG electromyography
  • the processing unit 1101 can transmit to and receive data from a remote database 16 using a communication module 1104 in the communication circuit 25.
  • EMG electromyography
  • Fig.3 is an isometric view of a wearable device in accordance with an embodiment of the present invention.
  • Fig.3 shows the main electronics housing 32 of the device and the band 31 of the device that interfaces with the user’s wrist.
  • Fig.4 is an exploded isometric view of a wearable device, in which the vibration motors are housed in the band rather than in the main electronics housing, in accordance with an embodiment of the present invention.
  • the mechanical transducers 1105 are housed in the band 31 which interfaces with the user's wrist. Between the top and bottom halves of the housing 321322, there is a printed circuit board (PCB) 42, a silicone square to insulate the bottom of the PCB 43, and a rechargeable battery 26.
  • the battery 26 includes protection circuitry to protect from overcharging and unwanted discharging.
  • a magnetic connector 421, coupled to the battery and mounted in the housing, is inserted into the PCB 42.
  • the magnetic connector 421 couples to a mating connector from an external charger, so that the battery 26 can be conveniently configured for charging by the external charger.
  • the magnetic connector 421 allows patients who have difficulty performing tasks that require fine motor skills to easily charge the device with a magnetic charging cable.
  • Fig.5 is an isometric view of a wearable device, in which the device includes a loop mechanism 51 to allow single handed adjustment of the band 31 on the user’s wrist, in accordance with an embodiment of the present invention.
  • Fig.5 shows the main electronics housing 32, the band 31 as it looks when worn on the user’s wrist, and an adjustment mechanism 51 that is integrated into the main electronics housing 32.
  • Fig.6 shows an embodiment of the present invention worn on a hand viewed from above.
  • Fig.6 shows the main electronics housing 32 and the band 31 that interfaces with the user’s wrist.
  • Fig.7 shows an embodiment of the present invention worn on a hand viewed from the side.
  • Fig.7 shows the main electronics housing 32, the band 31 that interfaces with the user’s wrist, and the on/off button 323 that a patient may use to begin/stop the vibrational stimulation.
  • the on/off button 323 is integrated into the main electronics housing 32.
  • Fig.8 shows a testing configuration for the wearable medical device, which may be used for more rigorous data collection, in accordance with an embodiment of the present invention.
  • Fig.8 shows the main electronics housing 32 and the band 31 that interfaces with the user's wrist.
  • Fig.9 illustrates a wearable device for mitigating movement disorder, in which the device is an accessory to a third-party smartwatch or other wearable computing device 91, in accordance with an embodiment of the present invention. In such an embodiment, some or all of the computation 912 and sensing 911 are offloaded to the third- party wearable device 91.
  • the third-party device then sends a set of motor commands wirelessly 94 (over Bluetooth for example 913925) to a processing unit 1101 on the accessory band 92.
  • This processing unit 1101 interfaces with the transducers 1105 on the band to execute the desired motor commands.
  • the accessory band 92 has its own battery 924.
  • the band also has its own specialized sensors 923 (such as electromyography sensors), the signals of which are communicated to the third- party processing unit 912 via the accessory processing unit 1101, and wireless communication 91392594. Data may also be logged to the user’s smartphone 93 over the same wireless connection 94.
  • Fig.10 shows a side view of a wearable device, which is as an accessory band for a third-party smartwatch or other wearable computing device, in accordance with an embodiment of the present invention. It shows the main electronics housing 32 and the band 31 which contains the mechanical transducers 1105. The band 31 interfaces with the user's wrist. This view illustrates an example placement of the accessory battery 925 and processing unit 1101.
  • Fig.11 shows a process by which a raw sensor input may be used to compute a set of stimulation parameters in accordance with an embodiment of the present invention.
  • the stimulation parameters are continuously updated in closed loop. These parameters can include any quantities used to define a stimulation waveform such as frequency, amplitude, phase, duty cycle, etc.
  • the current stimulation parameters 111 and raw sensor input 112 are used to filter out transducer/sensor crosstalk 113 either by using knowledge of the output waveform to subtract from the sensed waveform or by using knowledge of the timing of the output waveform to limit sensing to the “off” phases of a pulsing stimulation.
  • This filtering subsequently allows for feature extraction 114 of the raw sensor input 112.
  • the stimulation selection algorithm 115 uses the current stimulation parameters 111 and the extracted features 114 to select new stimulation parameters 116. This process is illustrated in greater depth in Figure 13. When the process repeats, the previously new stimulation parameters 116 become the current stimulation parameters 111.
  • Fig.12 shows a feature extraction process 114 in accordance with an embodiment of the present invention.
  • This process takes in a filtered sensor signal 113, as described with respect to Fig.11, and extracts temporal features 114111421143 and/or spectral features 1144.
  • Examples of common temporal features include the minimum value, the maximum value, first three standard deviation values, signal energy, root mean squared (RMS) amplitude, zero crossing rate, principal component analysis (PCA), kernel or wavelet convolution, or autoconvolution.
  • Examples of common spectral features include the Fourier Transform, fundamental frequency, (Mel-frequency) Cepstral coefficients, the spectral centroid, and bandwidth.
  • Features are extracted with standard digital signal processing techniques onboard the main processing unit of the device. The set of collected features is then fed into the stimulation selection algorithm 115.
  • Fig.13 shows a stimulation optimization algorithm 115 in accordance with an embodiment the present invention.
  • the stimulation selection algorithm takes in the extracted features 114 and the current stimulation parameters 111 and uses them to determine the set of new stimulation parameters 116.
  • the process by which the new parameters are determined is an optimization 1151 to minimize the symptom severity.
  • an extracted feature may be the amplitude of the tremor and the set of current stimulation parameters can be a stimulation waveform.
  • a stimulation selection algorithm can then compare the tremor amplitude observed with the current set of stimulation parameters to the tremor amplitude observed with a previous set of stimulation parameters to determine which of the two sets of stimulation parameters resulted in the lowest tremor amplitude.
  • the set with the lowest resulting tremor amplitude could then be used as the baseline for the next iteration of the stimulation selection algorithm which would compare it to a new set.
  • the structure of the output stimulation pattern may be a weighted average of optimized patterns corresponding to each symptom, where the weights are proportional to the symptom severity relative to the other observed symptoms. In some embodiments, the structure of the output stimulation pattern may just be the pattern optimized to reduce the most severe symptom.
  • Fig.14 shows a neurological signal cancelling system, illustrating how the wearable 11 device and body 12 interact, in accordance with an embodiment of the present invention in which the body and the device are considered collectively as an operative system. The system includes the user’s nervous system 1203, which sends control signals 141 to the body 12.
  • the wearable 11 senses the body’s movement and sends an opposing control signal 142 which is defined by the output of the active noise cancellation algorithm 143.
  • the control signals 141, 142 undergo a signal cancelling process within the nervous system of the user 1203, which results in a smoother perceived motion signal 144.
  • Fig.15 shows a process in which the raw sensor input 112 may be processed using active noise cancellation to compute a set of stimulation parameters, in accordance with an embodiment of the present invention.
  • the suite of movement disorder sensors 1106 within the device 11 quantify the real limb position and motion 1206 to produce a raw sensor input 112, which is then filtered using both a noise filter 113 and a movement disorder filter 151.
  • the noise filter 113 may use either knowledge of the output waveform to subtract from the sensed waveform or knowledge of the timing of the output waveform to limit sensing to the “off” phases of a pulsing stimulation.
  • the movement disorder filter 151 uses a 0-15Hz bandpass filter to eliminate any other signal components not caused by a movement disorder.
  • the resultant filtered sensor data 152 is then fed to the active noise cancellation processor 153, which generates the anti-tremor stimulation signal 154.
  • the active noise cancellation processor 153 is described in further detail in connection with Figs.16 and 17.
  • the device 11 uses vibrational stimulus 13 to transmit the anti-tremor stimulation signal 154 to the proprioceptors 1201 of the user’s body.
  • Fig.16 shows one exemplary embodiment of the process of anti-tremor stimulation signal 154 generation by the active noise cancellation (ANC) processor 153.
  • the ANC processor 153 takes the resulting filtered sensor data 152 of Fig.15 as input, which is then transformed into the frequency domain by applying a Fourier Transform 1531.
  • the fundamental frequency, ⁇ ⁇ the frequency having the greatest amplitude, is selected through ⁇ 1532 of the frequency domain data from the Fourier Transform 1531, and the output is used as the center of a bandpass filter 1533 to ensure an accurate time delay calculation 1534.
  • Fig.17 shows another exemplary embodiment of the process of anti-tremor stimulation signal 154 generation by the ANC processor 153.
  • the ANC processor 153 takes filtered sensor data 152 from an inertial motion unit (IMU) and calculates the resultant limb acceleration 171.
  • IMU inertial motion unit
  • the limb acceleration 171 in the time domain, is then transformed into the frequency domain by applying a Fourier Transform 1531, allowing the ANC processor 153 to extract the peak frequencies 172 of the limb acceleration using general peak finding algorithms, which take a set of data and return a set of local maxima, or peaks, such that the data points on either side of the peaks are less than said maxima.
  • the ANC processor 153 selects the window size 173 of the acceleration 171 by use of one of two methods. [0102]
  • the first method 174 uses the lowest peak frequency to calculate the window size. Selecting the lowest peak frequency ensures that all the relevant features of the limb acceleration 171 are captured in the window and able to be properly reproduced when generating the anti-tremor stimulation signal 154.
  • This method involves inverting the lowest peak frequency, which corresponds to the lowest frequency feature in the limb acceleration 171, and converting it into the time domain .
  • the lowest peak frequency is 3Hz, so the window size is .
  • the second method 175 uses a window size of fixed length. The acceleration data captured in the selected fixed window size is then inverted and becomes the anti-tremor stimulation signal 154 output. The lower bound of acceptable window size is found using the first method 174, the time domain conversion of the lowest peak frequency. A window smaller than this would fail to capture all of the relevant features of the limb acceleration 171. Theoretically, there is no upper bound of acceptable window size 173, but in practice, the upper bound will depend on the available memory of the device 11.
  • Fig.18 is a pair of renderings 181 and 182 by a tremor patient of an Archimedes spiral under conditions without and with treatment by a device in accordance with an embodiment of the present invention.
  • the spiral tracing test allows doctors to gain insight on the frequency, amplitude, and direction of their patients’ tremors. It can also inform the doctor of abnormal movement of hypokinesia, dystonia, and tremor.
  • the task requires the patient to continuously trace the Archimedes spiral. Patients who have tremors will have difficulty following the spiral and will trace off the spiral line resulting in a disordered spiral 181. Wearing a device in accordance with an embodiment of the present invention, the patient is able to trace the spiral more accurately resulting in a smoother spiral 182.
  • Fig.19 illustrates an embodiment of a simple non-convex gradient descent optimization used in an embodiment of the present invention for symptom reduction by searching over the parameter configuration space. It is a graphical representation of the stimulation selection algorithm 193 associated with the present invention.
  • the algorithm 193 moves through the stimulation parameter space 192 and attempts to minimize symptom severity 191.
  • the movement through the stimulation parameter space involves trying different sets of stimulation parameters and comparing their resulting symptom severities as quantified by their respective sensors.
  • the algorithm attempts to minimize symptom severity by testing different sets of parameters until an optimal set for minimizing symptom severity is found.
  • Diagnostic Applications Alternative benchtop versions of the device can be used to elicit tremors in Parkinson’s patients for the purposes of early detection.
  • Figs.20 and 21 each show a power spectral density (PSD) plot of the postural tremor of a Parkinson’s Disease and Essential Tremor patient, respectively, with and without the use of a device in accordance with an embodiment of the present invention.
  • PSD power spectral density
  • tremor amplitude is compared with and without the device.
  • Figs.22 and 23 show the tremor response of 21 PD and 8 ET patients, respectively, in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the phase rotation of the stimulation, and selecting the phase rotation which results in the greatest tremor mitigation.
  • the frequency of the stimulation was chosen by the active noise cancellation (ANC) processor, and thus varied between patients, but each patient’s testing session was performed at a singular frequency.
  • Figs.24 and 25 show the tremor response of 19 PD and 6 ET patients, respectively, in peak tremor displacement when stimulation was applied using the process of anti-tremor stimulation signal generation by varying the frequency of the stimulation, and selecting the frequency which results in the greatest tremor mitigation.
  • the phase rotation was not modulated.
  • Participants were asked to perform a number of tasks in which their tremor was observed both with and without stimulation. The tasks were extracted from validated scales for upper limb tremor evaluation in both PD and ET, the MDS-UPDRS (Movement Disorder Society-Unified Parkinson’s Disease Rating Scale) and TETRAS (The Essential Tremor Rating Assessment Scale), respectively.
  • MDS-UPDRS Movement Disorder Society-Unified Parkinson’s Disease Rating Scale
  • TETRAS The Essential Tremor Rating Assessment Scale
  • While the above embodiments reference accelerometers, vibration motors, microUSB, and wristbands the invention is not limited to such implementations. Additionally, the above embodiments are not intended to limit the scope of the invention. For example, various modifications and variations of interfaces, types of electromyography sensors, gyroscopes, inertial measurement units, piezoelectrics, electromagnets, electropermanent magnets, pneumatics, voice coils, hydraulics, resistive heating elements should be included. The scope of form factors should also include headbands, collars, anklets, armbands, and rings. The scope of electrical interfaces should include Thunderbolt cables, USB, USB C, microUSB, wireless communication, wireless charging, and Bluetooth communication.
  • the present invention may be embodied in many different forms, including, but in no way limited to, computer program logic for use with a processor (e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer), programmable logic for use with a programmable logic device (e.g., a Field Programmable Gate Array (FPGA) or other PLD), discrete components, integrated circuitry (e.g., an Application Specific Integrated Circuit (ASIC)), or any other means including any combination thereof.
  • a processor e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer
  • programmable logic for use with a programmable logic device
  • FPGA Field Programmable Gate Array
  • ASIC Application Specific Integrated Circuit
  • Source code may include a series of computer program instructions implemented in any of various programming languages (e.g., an object code, an assembly language, or a high-level language such as Fortran, C, C++, JAVA, or HTML) for use with various operating systems or operating environments.
  • the source code may define and use various data structures and communication messages.
  • the source code may be in a computer executable form (e.g., via an interpreter), or the source code may be converted (e.g., via a translator, assembler, or compiler) into a computer executable form.
  • the computer program may be fixed in any form (e.g., source code form, computer executable form, or an intermediate form) either permanently or transitorily in a tangible storage medium, such as a semiconductor memory device (e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM), a magnetic memory device (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), a PC card (e.g., PCMCIA card), or other memory device.
  • a semiconductor memory device e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM
  • a magnetic memory device e.g., a diskette or fixed disk
  • an optical memory device e.g
  • the computer program may be fixed in any form in a signal that is transmittable to a computer using any of various communication technologies, including, but in no way limited to, analog technologies, digital technologies, optical technologies, wireless technologies, networking technologies, and internetworking technologies.
  • the computer program may be distributed in any form as a removable storage medium with accompanying printed or electronic documentation (e.g., shrink wrapped software or a magnetic tape), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the communication system (e.g., the Internet or World Wide Web).
  • Hardware logic including programmable logic for use with a programmable logic device
  • implementing all or part of the functionality previously described herein may be designed using traditional manual methods, or may be designed, captured, simulated, or documented electronically using various tools, such as Computer Aided Design (CAD), a hardware description language (e.g., VHDL or AHDL), or a PLD programming language (e.g., PALASM, ABEL, or CUPL).
  • CAD Computer Aided Design
  • a hardware description language e.g., VHDL or AHDL
  • PLD programming language e.g., PALASM, ABEL, or CUPL

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Abstract

Une bande multimodale pouvant être portée utilise des vibrations mécaniques pour stimuler les neurones sensoriels dans le poignet ou la cheville afin de réduire la sévérité des tremblements, de la rigidité, des contractions musculaires involontaires et de la bradykinésie provoqués par des troubles neurologiques du mouvement et de libérer les utilisateurs de l'immobilisation induite par des troubles du mouvement. Le dispositif utilise des capteurs afin de fournir une sortie utilisée par une unité de traitement pour déterminer un motif de stimulation pour l'utilisateur et pour déterminer à quel moment une stimulation est nécessaire, et utilise ensuite un ou plusieurs transducteurs pour stimuler de manière correspondante les voies neurologiques de l'utilisateur afin de réduire la sévérité des symptômes de l'utilisateur. Le dispositif peut également être conçu pour s'intégrer à des dispositifs tiers.
PCT/US2021/053561 2020-10-05 2021-10-05 Appareil et procédé de réduction de symptômes de troubles neurologiques du mouvement à l'aide d'un dispositif pouvant être porté WO2022076405A1 (fr)

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CA3194995A CA3194995A1 (fr) 2020-10-05 2021-10-05 Appareil et procede de reduction de symptomes de troubles neurologiques du mouvement a l'aide d'un dispositif pouvant etre porte
EP21801735.8A EP4225139A1 (fr) 2020-10-05 2021-10-05 Appareil et procédé de réduction de symptômes de troubles neurologiques du mouvement à l'aide d'un dispositif pouvant être porté
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