WO2022058779A1 - Dispositif, système et méthode pour la détection précoce du cancer cervical - Google Patents

Dispositif, système et méthode pour la détection précoce du cancer cervical Download PDF

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Publication number
WO2022058779A1
WO2022058779A1 PCT/IB2020/058789 IB2020058789W WO2022058779A1 WO 2022058779 A1 WO2022058779 A1 WO 2022058779A1 IB 2020058789 W IB2020058789 W IB 2020058789W WO 2022058779 A1 WO2022058779 A1 WO 2022058779A1
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WO
WIPO (PCT)
Prior art keywords
image
cervical cancer
risk
endoscopic device
electronic endoscopic
Prior art date
Application number
PCT/IB2020/058789
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English (en)
Spanish (es)
Inventor
Marcela ARRIVILLAGA QUINTERO
Jorge Ivan BOTERO GALLEGO
Juan Pablo Garcia Cifuentes
Paula Cristina BERMUDEZ JARAMILLO
Original Assignee
Pontificia Universidad Javeriana, Seccional Cali
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pontificia Universidad Javeriana, Seccional Cali filed Critical Pontificia Universidad Javeriana, Seccional Cali
Priority to PCT/IB2020/058789 priority Critical patent/WO2022058779A1/fr
Publication of WO2022058779A1 publication Critical patent/WO2022058779A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons

Definitions

  • the present invention is framed in the technical field of medical devices, especially in the field of medical devices for the detection of cervical cancer.
  • the present invention refers to devices, systems and methods for the early detection of cervical cancer that include an electronic endoscopic device (110), a visualization and computing device (132), an image processing system and an output of preliminary declaration of risk/no risk of cervical precancerous lesions.
  • the electronic endoscopic device (110) has a thin and elongated means (111) connected at its proximal end to a handle (112).
  • the device 110 has two image capture means 113 and 114 at the distal end of its elongated section, which send images to be processed.
  • the system includes an electronic endoscopic device (110) for capturing images of the cervix, sent through a communication medium (130) to a computerized display and computing device (132) and the image processing system (IPS) ( 220) trained with artificial intelligence to determine if the submitted image reveals a risk of cervical cancer based on information collected through a database (230).
  • IPS image processing system
  • Cervical cancer is known to rank as the fourth most frequently diagnosed cancer and is the fourth leading cause of cancer death in women worldwide. In the United States, the annual mortality rate for uterine or cervical cancer reaches 2.4 samples per 100,000 women, which means that approximately 4 million people.
  • the conventional method of detecting abnormalities in the cervix comprises the following steps:
  • Another known technique for diagnosing cervical cancer is through the use of colposcope testing. This test is used to magnify the image of the cervix with a lens device so that a health professional can health evaluate the images obtained. In this case, a speculum is required to open the vaginal cavity.
  • these professionals must be well trained to visually determine the presence of abnormalities in the analyzed tissue to diagnose the potential risk of having cancer.
  • patent WO2017083588 teaches an apparatus and a method for detecting cervical cancer and tuberculosis, wherein the device comprises an inserted end that is configured to be inserted into an opening within the body of a user and an end not inserted that is configured to be outside the opening, a camera, a light source, and a nozzle for releasing a liquid into the opening.
  • the non-inserted end comprises an electronic device configured to store and analyze images taken by the camera.
  • the electronic device is further configured to monitor an amount of the liquid released through the nozzle into the opening, to validate the quality of the images, and to perform automated analysis of the images to diagnose a lesion or pathological abnormality within the opening.
  • Patent document CN102188228 is also known, which describes a portable electron microscopy detection technique for the prevention of cervical cancer, which is composed of a light source supply circuit system and a microelectronic microcamera system.
  • the electronic micro camera system is preset and fixed and features focal length o zoom to get the image enlarged with an electron microscope for a sharper image.
  • the light source supply circuit system controls the intensity of the light source required by adjusting a knob.
  • Figure 1 shows an illustration of the preliminary detection device or system for cervical cancer according to the present invention.
  • Figure 2 shows a slightly angled front view of the distal end of the thin elongated media (111).
  • Figure 3 shows an exploded view of the components of the electronic device according to the invention.
  • FIG. 4 shows a block diagram of the cervical cancer screening system according to various embodiments of the present invention.
  • Figure 5 shows a flow chart of the method for preliminary cervical cancer risk determination according to various embodiments of the present invention.
  • an automated device, system and method for the preliminary determination of cervical cancer wherein the device comprises
  • Figure 1 shows a preferred form of configuration of the preliminary detection system device for cervical cancer according to the present invention.
  • Figure 1 shows the device (110) comprising a computing device (132) which in turn comprises a screen (133) and a means of communication (130) that connects said computing device (132) and the device (110). ) that corresponds to the electronic endoscopic device.
  • This electronic endoscopic device (110), in a preferred embodiment of the invention, is characterized in that it comprises a thin and elongated medium (111), a handle or handle (112) connected to its proximal end and two image capture devices (113) and (114) inserted in the distal end of the thin and elongated medium (111).
  • the images are sent to an image processing system (shown in Figure 4) via the communication medium (130).
  • the sending can be done wirelessly between the device (110) and the computing device (132), which can be a smartphone (132), a laptop or laptop (134), a monitor (135) or a tablet (136).
  • the thin elongated media 111 contains a low cost hygienically sterilized disposable sheath to be replaced after each use. single procedure.
  • the elongated thin medium (111) has a cylindrical shape with a width of 0.5 inches (1.27 cm).
  • the grip or handle (112) is adapted to the shape of the fingers to be ergonomically held by the user's or medical professional's hand.
  • the grip or handle (112) comprises a camera shutter (116), proposed as a button on the upper surface of the grip (112).
  • the camera shutter 116 is pressed in the preferred embodiment, two images, one for each image capture device 113 and 114, are captured and sent to computing device 132 .
  • the camera shutter (116) is a trigger mechanism at the bottom of the grip (112).
  • the handle 112 comprises light adjustment means 115 for adjusting the light emitted into the vaginal canal to enhance proper observation.
  • the electronic endoscopic device (110) comprises a pneumatic device or system consisting of a pump (156) connected through a thin hose with an inflatable ring (157) located so fixed and removable at the distal end of the thin and elongated medium (111) whose function is to enlarge the field of vision of the image capture devices.
  • the elliptical or circular shaped accessory (157) is progressively inflated through the small pump (156) pressed by hand depending on the desired field of vision.
  • the electronic endoscopic device (110) also comprises a solution application mechanism (120), which is comprised of a refillable compartment (119), a conduit (121) connected to the distal end of the refillable compartment (119) and the ejection mechanism (120).
  • the refillable compartment (119) can be filled with a liquid solution used for visual inspection of the cervix based on in a coloration.
  • the solution is propelled from the refillable compartment (119) by the ejection mechanism (120) into a conduit (121) attached to the thin elongated means (111) of the electronic endoscopic device (110).
  • the ejection mechanism (120') By activating the ejection mechanism (120').
  • the solution can reach the conduit section (121) inside the distal end of the thin elongated medium (111) to adequately spray the cervix.
  • the refillable compartment (119) and conduit (121) are replaced.
  • the refillable compartment (119) is a hypodermic syringe and the conduit (121) is a thin tube.
  • the depicted syringe can contain up to 1 ml of solution, which is sufficient for a single detection procedure.
  • the refillable compartment (119) may be a capsule attached to or within the handle (112).
  • the ejection mechanism (120) is a button installed on the handle (112).
  • Figure 2 is a slightly angled front view representation of the distal end of the elongated thin media (111).
  • the image capture devices 113 and 14) can be seen side by side. They are surrounded by an illumination mechanism or device 142, preferably a uniformly distributed array of diodes, intended to enhance observation of the cervix.
  • the emitted light can be graduated using the light graduation means (115) depicted in Figure 1.
  • the edge of the conduit (143) of the solution application mechanism (120) described above is illustrated in the lower section of the distal end .
  • the pneumatic system or device (157) is also included, together with its connection (158) that connects to the hose that goes to the pump (156).
  • FIG 3 depicts the separate components of the endoscopic electronic device (110).
  • the grip (112) is shown with the camera shutter (116) and the light graduation means (115), both connected to the electronic box from where the cables of the devices emerge. image capture (113) and (114).
  • Shown at upper right is the elongated thin media (111), which includes a threaded mechanism (155) used to connect this section to the handle (112).
  • the pneumatic system or device is composed of the small pump (156) connected to the accessory elliptical or circular inflatable ring (157).
  • the solution application mechanism (120) is represented with its refillable compartment (119). This compartment (119) can be inserted into a cylindrical section (112') within the handle to facilitate manipulation of the electronic endoscopic device (110).
  • FIG. 4 depicts a block diagram of cervical cancer screening system 200, in accordance with various embodiments of the present invention.
  • the electronic endoscopic device (110) sends images using a communication medium (130) (which can be wired or wireless as mentioned above) to be projected on a display and computing mechanism the computing device (132) that can be a smartphone, a computer or a tablet, preferably but not exclusively a cell phone (132).
  • the display and computation mechanism (132) can be a laptop (134), a monitor (135) or any other device with a screen such as a tablet (136) (not shown in the figure).
  • the images captured by the electronic endoscopic device (110) through the image capture devices (113) and (114) are sent using the communication medium (130).
  • the communication means (130) is implemented in the form of a USB cable connected from the electronic endoscopic device (110) to the display and computing device (132).
  • the communication means (130) can be based on wireless communication protocols such as Bluetooth, Wi-Fi or other means already invented or to be invented.
  • the first image capture device (113) takes an image in the spectrum visible to the human eye, and preferably, but not exclusively, has a resolution of at least 2 MP.
  • the second capture device (114) takes an image in the infrared spectrum, seeking to improve the observation of the cervix and retrieve additional data for the image processing system.
  • image capture devices 113 and 114 may be disposable if constructed of inexpensive materials.
  • the newly captured images are displayed with the display and computation mechanism (132), (134), (135) or (136) and sent to the Image Processing System (IPS) 220 as shown in the figure 4 for AI-based processing.
  • the IPS (220) takes the information collected from the training database (230) and uses it to compare the newly received image in order to deliver an output (240) of the preliminary statement of risk or no risk with respect to the cervical cancer.
  • the IPS 220 is accessible through a cloud-based server.
  • the IPS (220) can be integrated into a computing device (132), (134), (135) or (136) (figures 1 and 4) that has a display mechanism (1339, to work outside
  • the IPS 220 may be periodically retrained with an updated database accessed through a cloud-based server for offline or online operations.
  • FIG. 3 depicts a block diagram 300 of the IPS used to determine preliminary cervical cancer risk in accordance with various embodiments of the present invention. The process follows these stages:
  • Image Capture (301) Images are captured using both image capture devices (113) and (114) and sent to IPS (220).
  • the preprocessing stage involves conventional techniques such as filtering, dilation, and erosion so that the image can be compared with information obtained from the training database.
  • this stage could also determine if an image is not suitable for IPS 220 processing due to a fogged lens, excessive blur, insufficient lighting, or if the image was taken from an incorrect angle.
  • AI artificial intelligence
  • the assistant determines the risk related to cervical cancer and sends a notification to the health professional indicating if the patient is at risk.
  • Figure 5 depicts a method for screening cervical cancer with an automated system (200) in accordance with various embodiments of the present invention. In the preferred embodiment, the following steps are performed (each item described here is shown in Figure 1 or Figure 4):
  • • 401 turn on the electronic endoscopic device (110), that is, connect its USB port preferably to a display and computing device (132) such as a cell phone, tablet or computer. Check that the interior lighting mechanism (142) is on. • 402: Insert the long thin medium (111) into the patient's vaginal canal until it reaches the cervix. The light can be adjusted with the gradual wheel-type mechanism (115).
  • the IPS 220 uses artificial intelligence to perform a screening procedure to detect precancerous lesions on the cervix.
  • the IPS 220 sends the image to a cell phone (132), computer (134), monitor (135) or tablet (136) or in general to any computing device (210), preferably with a display mechanism (133).
  • the system could be compatible with the database management system (not shown in the figures) used in the health center so that the results can be stored and maintained within the patient's historical record.
  • the step of applying liquid solution to contrast the captured image of the cervix is omitted.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endoscopes (AREA)

Abstract

La présente invention concerne des dispositifs, des systèmes et des méthodes de détection précoce du cancer du col de l'utérus qui incluent un dispositif d'endoscope électronique (110), un dispositif de visualisation et de calcul informatique (132), un système de traitement d'images et une sortie de déclaration préliminaire de risque/non risque de lésions cervicales précancéreuses. Selon un aspect de la présente invention, le dispositif d'endoscope électronique (110) présente un moyen mince et allongé (111) relié par son extrémité proximale à une poignée (112). Le dispositif (110) comporte deux moyens de capture d'images (113) et (114) dans l'extrémité distale de sa section allongée, qui envoient des images devant être traitées. Le système comprend un dispositif d'endoscope électronique (110) pour capturer des images du col de l'utérus, envoyées par un moyen de communication (130) à un dispositif de visualisation et de calcul informatique (132) et le système de traitement d'images (IPS) (220) associé à une intelligence artificielle pour déterminer si l'image envoyée révèle un risque de cancer du col de l'utérus en fonction des informations récupérées dans une base de données (230).
PCT/IB2020/058789 2020-09-21 2020-09-21 Dispositif, système et méthode pour la détection précoce du cancer cervical WO2022058779A1 (fr)

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PCT/IB2020/058789 WO2022058779A1 (fr) 2020-09-21 2020-09-21 Dispositif, système et méthode pour la détection précoce du cancer cervical

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PCT/IB2020/058789 WO2022058779A1 (fr) 2020-09-21 2020-09-21 Dispositif, système et méthode pour la détection précoce du cancer cervical

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059321A2 (fr) * 2004-11-30 2006-06-08 O.D.F. Medical Ltd. Systeme d'observation gynecologique compact destine a l'examen medical, l'imagerie, l'analyse d'image et au traitement medical
US20070213590A1 (en) * 2003-10-09 2007-09-13 Gyntec Medical, Inc. Apparatus and methods for examining, visualizing, diagnosing, manipulating, treating and recording of abnormalities within interior regions of body cavities
WO2015077684A1 (fr) * 2013-11-22 2015-05-28 Duke University Colposcope comportant des émetteurs de lumière et des dispositifs de capture d'image, et procédés associés
WO2017083588A1 (fr) * 2015-11-10 2017-05-18 Davey Neil Shivraj Appareil et procédé pour détecter le cancer du col de l'utérus et la tuberculose
WO2019030749A1 (fr) * 2017-08-06 2019-02-14 Biop - Medical Ltd Sonde optique pour examen cervical
WO2019053499A1 (fr) * 2017-09-18 2019-03-21 MOKTALI Veena Dispositif numérique facilitant le dépistage et le diagnostic de la cavité corporelle

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070213590A1 (en) * 2003-10-09 2007-09-13 Gyntec Medical, Inc. Apparatus and methods for examining, visualizing, diagnosing, manipulating, treating and recording of abnormalities within interior regions of body cavities
WO2006059321A2 (fr) * 2004-11-30 2006-06-08 O.D.F. Medical Ltd. Systeme d'observation gynecologique compact destine a l'examen medical, l'imagerie, l'analyse d'image et au traitement medical
WO2015077684A1 (fr) * 2013-11-22 2015-05-28 Duke University Colposcope comportant des émetteurs de lumière et des dispositifs de capture d'image, et procédés associés
WO2017083588A1 (fr) * 2015-11-10 2017-05-18 Davey Neil Shivraj Appareil et procédé pour détecter le cancer du col de l'utérus et la tuberculose
WO2019030749A1 (fr) * 2017-08-06 2019-02-14 Biop - Medical Ltd Sonde optique pour examen cervical
WO2019053499A1 (fr) * 2017-09-18 2019-03-21 MOKTALI Veena Dispositif numérique facilitant le dépistage et le diagnostic de la cavité corporelle

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARRIVILLAGA MARCELA, BERMÚDEZ PAULA C., GARCÍA-CIFUENTES JUAN PABLO, BOTERO JORGE: "Innovative prototypes for cervical cancer prevention in low-income primary care settings: A human-centered design approach", PLOS ONE, vol. 15, no. 8, 24 August 2020 (2020-08-24), pages e0238099-1 - e0238099-22, XP055917503, DOI: 10.1371/journal.pone.0238099 *

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