WO2022053993A3 - Treatments for sars-cov-2 infection (covid-19) - Google Patents

Treatments for sars-cov-2 infection (covid-19) Download PDF

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Publication number
WO2022053993A3
WO2022053993A3 PCT/IB2021/058235 IB2021058235W WO2022053993A3 WO 2022053993 A3 WO2022053993 A3 WO 2022053993A3 IB 2021058235 W IB2021058235 W IB 2021058235W WO 2022053993 A3 WO2022053993 A3 WO 2022053993A3
Authority
WO
WIPO (PCT)
Prior art keywords
covid
cov
sars
infection
treatments
Prior art date
Application number
PCT/IB2021/058235
Other languages
French (fr)
Other versions
WO2022053993A2 (en
Inventor
Abhijit DESHMUKH
Abhijit Barve
Ravi Shankar
Prasanna C GANAPATHI
Akhilesh DIXIT
Amit ANTARKAR
Santanu Chakraborty
Ram A. Vishwakarma
Srivari CHANDRASEKHAR
Original Assignee
Mylan Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Limited filed Critical Mylan Laboratories Limited
Publication of WO2022053993A2 publication Critical patent/WO2022053993A2/en
Publication of WO2022053993A3 publication Critical patent/WO2022053993A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Active agent combinations are provided for the treatment and/or prevention of COVID-19.
PCT/IB2021/058235 2020-09-12 2021-09-10 Treatments for sars-cov-2 infection (covid-19) WO2022053993A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202041039535 2020-09-12
IN202041039535 2020-09-12

Publications (2)

Publication Number Publication Date
WO2022053993A2 WO2022053993A2 (en) 2022-03-17
WO2022053993A3 true WO2022053993A3 (en) 2022-04-21

Family

ID=80631363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/058235 WO2022053993A2 (en) 2020-09-12 2021-09-10 Treatments for sars-cov-2 infection (covid-19)

Country Status (1)

Country Link
WO (1) WO2022053993A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11655240B1 (en) 2022-05-10 2023-05-23 Beijing Grand Johamu Pharmaceutical Company, Ltd. Crystal form of compound and fumaric acid, pharmaceutical composition and method for treating coronavirus-induced diseases
CN117159556A (en) * 2022-05-27 2023-12-05 北京远大九和药业有限公司 Pharmaceutical composition and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089383A1 (en) * 2003-04-14 2004-10-21 Cipla Limited Pharmaceutical combinations comprising lamivudine, stavudine and efavirenz for treating viral infections
US20150238489A1 (en) * 2012-08-31 2015-08-27 Novadrug, Llc Heterocyclyl carboxamides for treating viral diseases
US20200230198A1 (en) * 2016-06-20 2020-07-23 Kansas State University Research Foundation Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses
US20200276262A1 (en) * 2017-10-06 2020-09-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Peptides for use in the treatment of viral infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089383A1 (en) * 2003-04-14 2004-10-21 Cipla Limited Pharmaceutical combinations comprising lamivudine, stavudine and efavirenz for treating viral infections
US20150238489A1 (en) * 2012-08-31 2015-08-27 Novadrug, Llc Heterocyclyl carboxamides for treating viral diseases
US20200230198A1 (en) * 2016-06-20 2020-07-23 Kansas State University Research Foundation Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses
US20200276262A1 (en) * 2017-10-06 2020-09-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Peptides for use in the treatment of viral infections

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMAT-SANTOS IGNACIO J.; SANTOS-MARTINEZ SANDRA; LóPEZ-OTERO DIEGO; NOMBELA-FRANCO LUIS; GUTIéRREZ-IBANES ENRIQUE; DEL VA: "Ramipril in High-Risk Patients With COVID-19", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 76, no. 3, 26 May 2020 (2020-05-26), AMSTERDAM, NL, pages 268 - 276, XP086213202, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2020.05.040 *
GAO YAN, YAN LIMING, HUANG YUCEN, LIU FENGJIANG, ZHAO YAO, CAO LIN, WANG TAO, SUN QIANQIAN, MING ZHENHUA, ZHANG LIANQI, GE JI, ZHE: "Structure of the RNA-dependent RNA polymerase from COVID-19 virus", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 368, no. 6492, 15 May 2020 (2020-05-15), US , pages 779 - 782, XP055934767, ISSN: 0036-8075, DOI: 10.1126/science.abb7498 *
JANOWITZ TOBIAS, GABLENZ EVA, PATTINSON DAVID, WANG TIMOTHY C, CONIGLIARO JOSEPH, TRACEY KEVIN, TUVESON DAVID: "Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 69, no. 9, 1 September 2020 (2020-09-01), UK , pages 1592 - 1597, XP055793948, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2020-321852 *
LOU YAN; LIU LIN; YAO HANGPING; HU XINGJIANG; SU JUNWEI; XU KAIJIN; LUO RUI; YANG XI; HE LINGJUAN; LU XIAOYANG; ZHAO QINGWEI; LIAN: "Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 157, 25 October 2020 (2020-10-25), NL , XP086422279, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2020.105631 *
SAHA RUDRA P., SHARMA ASHISH RANJAN, SINGH MANOJ K., SAMANTA SAIKAT, BHAKTA SWARNAV, MANDAL SNEHASISH, BHATTACHARYA MANOJIT, LEE S: "Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 11, 19 January 2020 (2020-01-19), CH , XP055873445, ISSN: 1663-9812, DOI: 10.3389/fphar.2020.01258 *

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Publication number Publication date
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