WO2022050694A9 - Biomimetic tissue-adhesive hydrogel patch for preventing or treating cartilage or bone diseases - Google Patents

Biomimetic tissue-adhesive hydrogel patch for preventing or treating cartilage or bone diseases Download PDF

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Publication number
WO2022050694A9
WO2022050694A9 PCT/KR2021/011780 KR2021011780W WO2022050694A9 WO 2022050694 A9 WO2022050694 A9 WO 2022050694A9 KR 2021011780 W KR2021011780 W KR 2021011780W WO 2022050694 A9 WO2022050694 A9 WO 2022050694A9
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel patch
preventing
bone diseases
treating cartilage
adhesive hydrogel
Prior art date
Application number
PCT/KR2021/011780
Other languages
French (fr)
Korean (ko)
Other versions
WO2022050694A1 (en
Inventor
조승우
최수정
전은제
이종승
Original Assignee
주식회사 세라트젠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 세라트젠 filed Critical 주식회사 세라트젠
Priority to CN202180053740.XA priority Critical patent/CN116113403A/en
Priority to EP21864653.7A priority patent/EP4190316A1/en
Publication of WO2022050694A1 publication Critical patent/WO2022050694A1/en
Publication of WO2022050694A9 publication Critical patent/WO2022050694A9/en
Priority to US18/176,890 priority patent/US20230201109A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a hydrogel patch comprising phenyl group-modified biocompatible macromolecules, and to a hydrogel patch for preventing or treating cartilage or bone diseases containing the bone disease-treating medicine carried in the hydrogel patch.
PCT/KR2021/011780 2020-09-01 2021-09-01 Biomimetic tissue-adhesive hydrogel patch for preventing or treating cartilage or bone diseases WO2022050694A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202180053740.XA CN116113403A (en) 2020-09-01 2021-09-01 Bionic tissue adhesive hydrogel patch for preventing or treating cartilage or bone diseases
EP21864653.7A EP4190316A1 (en) 2020-09-01 2021-09-01 Biomimetic tissue-adhesive hydrogel patch for preventing or treating cartilage or bone diseases
US18/176,890 US20230201109A1 (en) 2020-09-01 2023-03-01 Bio-inspired tissue-adhesive hydrogel patch for preventing or treating cartilage or bone disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2020-0111332 2020-09-01
KR1020200111332A KR102483403B1 (en) 2020-09-01 2020-09-01 Bio-inspired tissue-adhesive hydrogel patch for preventing or treating cartilage or bone disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US18/176,890 Continuation US20230201109A1 (en) 2020-09-01 2023-03-01 Bio-inspired tissue-adhesive hydrogel patch for preventing or treating cartilage or bone disease

Publications (2)

Publication Number Publication Date
WO2022050694A1 WO2022050694A1 (en) 2022-03-10
WO2022050694A9 true WO2022050694A9 (en) 2022-05-12

Family

ID=80491823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/011780 WO2022050694A1 (en) 2020-09-01 2021-09-01 Biomimetic tissue-adhesive hydrogel patch for preventing or treating cartilage or bone diseases

Country Status (5)

Country Link
US (1) US20230201109A1 (en)
EP (1) EP4190316A1 (en)
KR (1) KR102483403B1 (en)
CN (1) CN116113403A (en)
WO (1) WO2022050694A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240019910A (en) * 2022-08-05 2024-02-14 주식회사 씨케이리제온 Hydrogel patches for wound healing or reducing scar

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101103423B1 (en) * 2009-09-04 2012-01-06 아주대학교산학협력단 In situ forming hydrogel for tissue adhesives and biomedical use thereof
KR101552387B1 (en) * 2012-05-29 2015-09-10 한국교통대학교산학협력단 Method of Manufacturing Crosslinked Hydrogel for Drug Delivery system
CN109526207B (en) * 2017-03-14 2022-11-25 仰卧疗法有限公司 Hydrogel patch
KR20200017625A (en) * 2018-08-09 2020-02-19 (주)앰틱스바이오 Use of modified hyaluronic acids for delivering biomolecules or drugs in vivo

Also Published As

Publication number Publication date
EP4190316A1 (en) 2023-06-07
WO2022050694A1 (en) 2022-03-10
CN116113403A (en) 2023-05-12
KR102483403B1 (en) 2022-12-30
KR20220029249A (en) 2022-03-08
US20230201109A1 (en) 2023-06-29

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