WO2022049949A1

WO2022049949A1 - Ultrafine mist supply system

Info

Publication number: WO2022049949A1
Application number: PCT/JP2021/028361
Authority: WO
Inventors: 康司川崎; 嘉貴緒方; 大輔角田; 純益留; 志強郭; 司北野
Original assignee: 株式会社エアレックス
Priority date: 2020-09-04
Filing date: 2021-07-30
Publication date: 2022-03-10
Also published as: TW202210109A; JPWO2022049949A1

Abstract

Provided is an ultrafine mist supply system in which a decontamination liquid is formed into an ultrafine mist, allowing a small and appropriate amount of the decontamination liquid to be supplied to a room being decontaminated and to be dispersed and delivered everywhere inside the room being decontaminated. Thus, the ultrafine mist supply system makes it possible to ensure that the effect of decontamination is complete and to improve the efficiency of decontamination work by shortening the time of work for aeration or the like. The ultrafine mist supply system comprises a mist releasing means and a focused ultrasonic generating means. The mist releasing means includes an ultrasonic atomization device that turns a decontamination liquid into a fine mist and that releases the fine mist through a release port into a room being decontaminated. The focused ultrasound generating means has a plurality of vibration panels in the vicinity of the release port of the ultrasonic atomization device, and ultrasonically vibrates the vibration panels in the same phase to cause an ultrasonic acoustic flow with ultrasonic directionality to be generated from each panel surface in the vertical direction. The plurality of vibration panels are arranged so that the directions of directionality of the respective ultrasonic acoustic flows converge ahead in a release direction of the mist being released through the release port of the ultrasonic atomization device.

Description

Ultra-fine mist supply system

The present invention relates to an ultrafine mist supply system that supplies a decontamination liquid as an ultrafine mist, and more particularly to an ultrafine mist supply system that supplies a fine mist as an ultrafine mist.

It is important to maintain the aseptic condition in the room at the manufacturing site where pharmaceuticals or foods are manufactured, or at the medical site such as an operating room. In particular, in the decontamination of a sterile room, which is a working room for manufacturing pharmaceutical products, it is necessary to complete advanced decontamination validation in line with GMP (Good Manufacturing Practice).

In recent years, hydrogen peroxide (gas or mist) has been widely adopted for decontamination of work rooms such as sterile rooms (hereinafter referred to as decontamination target rooms). This hydrogen peroxide has a strong sterilizing effect, is inexpensive and easily available, and is effective as an environment-friendly decontamination gas that finally decomposes into oxygen and water. Therefore, many proposals such as the following Patent Document 1 have been made to gasify hydrogen peroxide solution into the decontamination target chamber and efficiently supply it.

On the other hand, it is described in Patent Document 1 below that the decontamination effect of hydrogen peroxide is due to the condensed film of hydrogen peroxide solution that condenses on the surface of the decontamination target site. That is, decontamination is performed by condensing the hydrogen peroxide gas supplied by gasification on the surface of the decontamination target portion such as the wall surface of the decontamination target chamber. Therefore, in order to perfect the decontamination effect of the decontamination target room and improve the efficiency of the decontamination operation, the supply amount of hydrogen peroxide gas is increased to quickly generate a condensed film of hydrogen peroxide solution. Alternatively, it is conceivable to supply the hydrogen peroxide solution in a liquid state (for example, in droplets).

Japanese Unexamined Patent Publication No. 2006-320392 Special Publication No. 61-4543

By the way, if an excessive amount of hydrogen peroxide gas is supplied to the decontamination target room or a droplet of hydrogen peroxide solution is directly supplied, excessive condensation or uneven condensation occurs inside the decontamination target room. There is a problem that the various manufacturing equipment, precision measuring equipment, or the wall surface of the decontamination target room, which are arranged, are corroded by the condensed film of high-concentration hydrogen peroxide solution generated. In addition, after decontamination with hydrogen peroxide, aeration is performed to remove the hydrogen peroxide and the condensed film remaining inside the decontamination target chamber with clean air. However, when an excessive amount of hydrogen peroxide gas or droplets of hydrogen peroxide solution is supplied, it is often used for aeration to remove the condensed film of high-concentration hydrogen peroxide solution generated on the wall surface of the decontamination target room. There was a problem that it took time.

Therefore, the present invention addresses the above-mentioned problems and uses an ultrafine mist as the decontamination liquid to supply a small amount of an appropriate amount of the decontamination liquid to the decontamination target room and the decontamination target room. We provide an ultra-fine mist supply system that can completely disperse and reach the inside of the room, so that the decontamination effect can be perfected, and the work time for aeration etc. can be shortened to improve the efficiency of decontamination work. The purpose is to do.

In order to solve the above problems, the present inventors have made a decontamination liquid into a mist as a result of diligent research, and by applying a converged ultrasonic acoustic flow to the mist, the decontamination liquid becomes a finer ultrafine mist and peroxidation. We have found that the gasification of hydrogen can be promoted, and have completed the present invention. The numbers in parentheses described in each of the following claims are symbols indicating each component of the embodiment according to the present invention.

That is, according to the description of claim 1, the ultrafine mist supply system (20) according to the present invention is described.
The mist discharging means (30) that discharges the mist (61) of the decontamination liquid into the decontamination target chamber (10) and the mist of the discharged decontamination liquid are made ultrafine to promote gasification. It has a convergent ultrasonic wave generating means (40) that disperses and reaches the inside of the decontamination target room.
The mist discharging means includes an ultrasonic atomizing device (32) that converts the decontaminating liquid into fine mist and discharges it from a discharge port into the inside of the decontamination target chamber.
The convergent ultrasonic generating means is provided with a plurality of vibrating discs (41a to 41d) in the vicinity of the discharge port of the ultrasonic atomizing device, and the plurality of vibrating discs are ultrasonically vibrated in the same phase to be ultrasonically vibrated from each disc surface. A directional ultrasonic acoustic flow (42a to 42d) is generated by ultrasonic waves in the vertical direction, and the directing direction of each ultrasonic acoustic flow is in front of the discharge direction of the mist discharged from the discharge port of the ultrasonic atomizer. By arranging the plurality of vibrating discs so as to converge at
The mist discharged from the discharge port of the ultrasonic atomizer is converted into finer ultrafine mist (60) and gasification is promoted, and the ultrafine mist reaches a position away from the discharge port. It is characterized by letting it.

Further, according to the second aspect of the present invention, the ultrafine mist supply system according to the first aspect of the present invention.
The mist discharging means has a preliminary mist supplying means (50) for supplying the decontaminating liquid as a preliminary mist.
The preliminary mist supply means comprises a compressed air generator (51) for generating compressed air, a decontamination liquid supply device (52) for supplying the decontamination liquid, and a gas solution of the compressed air and the decontamination liquid. The pre-mist generator (53) that mixes and generates pre-mist, the air supply pipe (51a) that communicates between the compressed air generator and the pre-mist generator, and the decontamination liquid supply device to the above-mentioned A decontamination liquid supply pipe (52a) that communicates with the preliminary mist generator and a spare mist supply pipe (53a) that communicates from the preliminary mist generator to the mist discharging means are provided.
The mist releasing means includes a preliminary mist receptor (31), and the preliminary mist receptor is an air vent (31b) that discharges air separated from the preliminary mist supplied through the preliminary mist supply pipe to the outside. )
The ultrasonic atomizer is a porous vibration in which a plurality of micropores for atomizing the decontamination liquid separated by gas and liquid are provided through the front and back by the vibration of the piezoelectric vibrator (32b) and the piezoelectric vibrator. A plate (32a) is provided, and the surface of the porous diaphragm is directed toward the inside of the decontamination target chamber as the discharge port.

Further, according to the description of claim 3, the present invention is the ultrafine mist supply system according to

claim

1 or 2.
The ultrasonic atomizer is disposed with the front surface of the porous diaphragm facing the inside of the decontamination target chamber as the discharge port and the back surface facing the inside of the preliminary mist receptor.
The preliminary mist supplied to the preliminary mist receiver is discharged from the preliminary mist supply pipe toward the back surface of the porous diaphragm and separated into gas and liquid, and the separated decontamination liquid is discharged from the back surface to the front surface of the porous diaphragm. It is characterized in that it is atomized when it moves to the inside of the decontamination target chamber and is discharged from the surface to the inside of the decontamination target chamber.

Further, according to the description of claim 4, the present invention is the ultrafine mist supply system according to

claim

1 or 2.
In the ultrasonic atomizer, the front surface of the porous diaphragm is directed toward the inside of the decontamination target chamber as the discharge port, and the back surface is directed toward the liquid pool provided at the inner lower end of the preliminary mist receptor. Set up,
The preliminary mist supplied to the preliminary mist receptor is discharged from the preliminary mist supply pipe into the inside of the preliminary mist receptor and separated into gas and liquid, and the separated decontamination liquid is the liquid pool of the preliminary mist receptor. It is characterized in that it is atomized when it moves from the back surface to the front surface of the porous diaphragm and is discharged from the surface to the inside of the decontamination target chamber.

According to the above configuration, in the ultrafine mist supply system according to the present invention, the mist discharging means for discharging the mist of the decontamination liquid into the decontamination target chamber and the mist of the discharged decontamination liquid are made ultrafine. It has a convergent ultrasonic wave generating means that disperses and reaches the inside of the decontamination target chamber by promoting gasification. The mist discharging means includes an ultrasonic atomizing device that converts the decontaminating liquid into fine mist and discharges it from the discharge port into the inside of the decontamination target chamber. The convergent ultrasonic generation means is provided with a plurality of vibrating discs near the emission port of the ultrasonic atomizer, and these vibrating discs are ultrasonically vibrated in the same phase to be directed by ultrasonic waves in the vertical direction from each disc surface. Generates an ultrasonic acoustic flow.

A plurality of vibrating discs are arranged so that the directivity direction of these ultrasonic acoustic flows converges in front of the emission direction of the mist emitted from the emission port of the ultrasonic atomizer. As a result, the mist emitted from the discharge port of the ultrasonic atomizer is converted into finer ultrafine mist and gasification is promoted, and the ultrafine mist reaches a position away from the discharge port. Can be done.

As described above, according to the above configuration, by making the decontamination liquid an ultrafine mist, a small amount of an appropriate amount of the decontamination liquid is supplied to the decontamination target room, and the inside of the decontamination target room is completely filled. Since it can be dispersed and reached, it is possible to provide an ultrafine mist supply system that can achieve perfect decontamination effect, shorten work time such as aeration, and improve efficiency of decontamination work.

Further, according to the above configuration, the ultrafine mist supply system has a preliminary mist supply means for supplying the decontamination liquid as a preliminary mist to the mist discharge means. The preliminary mist supply means is a compressed air generator that generates compressed air, a decontamination liquid supply device that supplies a decontamination liquid, and a preliminary mist that generates a preliminary mist by mixing the compressed air and the decontamination liquid in a gas-liquid manner. An air supply pipe that communicates between the generator and the compressed air generator to the spare mist generator, a decontamination liquid supply pipe that communicates from the decontamination liquid supply device to the spare mist generator, and a spare mist generator. It is equipped with a spare mist supply pipe that communicates between the device and the mist discharging means.

The mist discharging means includes a spare mist receptor, and the spare mist receptor is equipped with an air vent that discharges air separated from the spare mist supplied through the spare mist supply pipe to the outside. The ultrasonic atomizer includes a piezoelectric vibrator and a porous diaphragm provided with a plurality of micropores penetrating the front and back to atomize the decontamination liquid separated by gas and liquid by the vibration of the piezoelectric vibrator. The surface of this porous diaphragm is directed toward the inside of the decontamination target chamber as a discharge port. This makes it possible to exert the above-mentioned action and effect more concretely.

Further, according to the above configuration, the ultrasonic atomizer is arranged so that the front surface of the porous diaphragm is directed toward the inside of the decontamination target chamber and the back surface is directed toward the inside of the preliminary mist receptor. The spare mist supplied to the spare mist receptor is discharged from the spare mist supply pipe toward the back surface of the porous diaphragm and separated into gas and liquid, and the separated decontamination liquid moves from the back surface to the front surface of the porous diaphragm. At the time, it atomizes and is released from the surface into the decontamination target chamber. This makes it possible to exert the above-mentioned action and effect more concretely.

Further, according to the above configuration, in the ultrasonic atomizer, the front surface of the porous diaphragm is directed toward the inside of the decontamination target chamber as a discharge port, and the back surface is a liquid pool provided at the inner lower end of the preliminary mist receptor. Arranged toward you. The spare mist supplied to the spare mist receptor was discharged from the spare mist supply pipe into the inside of the spare mist receptor and separated into gas and liquid, and the separated decontamination liquid was collected in the pool of the spare mist receptor. Later, when it moves from the back surface to the front surface of the porous diaphragm, it is atomized and released from the front surface into the decontamination target chamber. This makes it possible to exert the above-mentioned action and effect more concretely.

It is a schematic perspective view which sees through the inside of the isolator which deployed the ultrafine mist supply system which concerns on this invention. FIG. 1 is a schematic configuration diagram of the ultrafine mist supply system of FIG. 1 as viewed from the inside of the isolator, and is a front view (A) and a perspective view (B). It is (A) front view and (B) side sectional view which shows an example of the mist discharging means constituting the ultrafine mist supply system of FIG. It is a graph which shows the measurement result of the hydrogen peroxide gas concentration inside the isolator in each test of an Example. The decontamination effect of each part of the work glove deployed inside the isolator in each test of the example, (A) the part where the enzyme indicator is attached to the work glove, and (B) the LRD value of the enzyme indicator. It is a graph which shows.

In the ultrafine mist supply system according to the present invention, the decontamination target room is a clean room, an isolator, a RABS, or the inside of a pass room, a pass box, etc. connected to these decontamination target rooms, or these decontamination target rooms. Refers to a supply system for supplying a decontamination liquid to the inside of the decontamination target room in order to decontaminate the decontamination target device or the decontamination target article arranged inside the decontamination target room. Further, the ultrafine mist supply system according to the present invention refers to a supply system in which the decontamination liquid is converted into ultrafine mist and supplied, unlike the conventional supply device that gasifies and supplies the decontamination liquid.

Further, the ultrafine mist supply system according to the present invention not only converts the decontamination liquid into ultrafine mist and supplies it, but also converts other liquids such as water into ultrafine mist and supplies it. Can be used. For example, when the humidity inside the isolator is adjusted prior to decontamination, the ultrafine mist supply system according to the present invention is used to supply ultrafine water mist (also referred to as fog) into the room for decontamination. It may be used when adjusting the humidity to the optimum humidity.

In the present invention, "mist" is broadly interpreted as a state of droplets that are atomized and suspended in the air, a state in which gas and droplets are mixed, and a state of condensation between gas and droplets. It shall include the state where the phase change between the gas and the evaporation is repeated. In the present invention, these "mists" are further subdivided and used as "preliminary mist", "mist", and "ultrafine mist" in order from the one having the largest particle size according to the particle size of the main components constituting the mist. do.

First, the "preliminary mist" referred to in the present invention does not contain only particles having a particle size of 10 μm or less, which is generally defined as mist, but also contains droplets having a particle size larger than that. It means that the state of the droplets floating inside is the main component (main, not all). Examples of the preliminary mist generating means include a one-fluid spray nozzle for directly mistizing a liquid, a piezo high-pressure injection device, an immersion type ultrasonic atomizing device, a disk type atomizing device, and a disk mesh type atomizing device. In addition, there are ejectors and two-fluid spray nozzles that mist liquids with high-pressure air.

Next, the "mist" referred to in the present invention is a particle having a size of 10 μm or less, which is generally defined as a mist, as a main component (mainly, not all) by the action of ultrasonic vibration. It also includes particles of 5 μm or less, which is generally defined as fog.

Further, the "ultrafine mist" referred to in the present invention includes a fog of 5 μm or less in which the mist generated by the action of ultrasonic vibration is affected by the action of the convergent ultrasonic generation means (details will be described later), but is further super. It refers to those whose main component (main but not all) is homogenized into fine ultrafine particles of 3 μm or less. Since the particle size of this ultrafine mist is very small, the surface area is large, and the phase change between condensation and evaporation is actively repeated between the gas and the mist. Therefore, when the decontamination liquid is an ultrafine mist, the decontamination effect and decontamination efficiency should be maintained high by the phase change between condensation and evaporation in which the decontamination liquid is actively repeated between the gas and the mist. Can be done.

Hereinafter, the ultrafine mist supply system according to the present invention will be described in detail with specific embodiments. The present invention is not limited to the following embodiments. In the ultrafine mist supply system according to the embodiment shown below, hydrogen peroxide solution is used as the decontamination liquid. The decontamination solution supplied by the ultrafine mist supply system according to the present invention is not limited to the hydrogen peroxide solution, and may be a liquid decontamination solution such as an aqueous solution of peracetic acid.

This embodiment relates to an ultrafine mist supply system installed in an isolator as a decontamination target room. FIG. 1 is a schematic perspective view showing the inside of an isolator in which the ultrafine mist supply system according to the present invention is deployed. In FIG. 1, an ultrafine mist supply system 20 is deployed on the upper part of the right side wall surface of the isolator 10. The ultrafine mist supply system 20 has a mist discharging means 30 and a convergent ultrasonic wave generating means 40 (details will be described later).

Further, outside the isolator 10, a spare mist supply means 50 for supplying the spare mist to the ultrafine mist supply system 20 is provided. The spare mist supply means 50 includes an air compressor 51 that generates compressed air, a hydrogen peroxide solution tank 52, and an ejector 53. The air compressor 51 acts as a compressed air generator for generating compressed air as a carrier gas for transporting a hydrogen peroxide solution. The generated compressed air is supplied to the ejector 53 via the air supply pipe 51a. The air compressor 51 can be arranged at a position away from the isolator 10.

The hydrogen peroxide solution tank 52 acts as a decontamination liquid supply device for storing the hydrogen peroxide solution, which is a source of the ultrafine mist of the hydrogen peroxide solution as the decontamination mist. The hydrogen peroxide solution is supplied to the ejector 53 by the supply pump 52b via the decontamination liquid supply pipe 52a. The hydrogen peroxide solution tank 52 can be arranged in the vicinity of the air compressor 51 and at a position away from the isolator 10.

Here, the concentration of the hydrogen peroxide solution stored in the hydrogen peroxide solution tank 52 is not particularly limited, but in general, 30 to 35% by weight should be used in consideration of handling of dangerous substances and the like. Is preferable. Further, the hydrogen peroxide solution tank 52 includes a weighing meter 52c for detecting the remaining amount of the hydrogen peroxide solution inside, and a control device (not shown) for controlling the remaining amount.

The ejector 53 acts as a preliminary mist generator for generating a preliminary mist by mixing a hydrogen peroxide solution with compressed air. The generated spare mist is supplied to the ultrafine mist supply system 20 via the spare mist supply pipe 53a. The ejector 53 can be arranged in the vicinity of the air compressor 51 and the hydrogen peroxide solution tank 52 at a position away from the isolator 10.

Here, the preliminary mist generator is not limited to the ejector, but is not limited to the above-mentioned one-fluid spray nozzle, piezo high-pressure injection device, immersion type ultrasonic atomization device, disk type atomization device, and disk mesh type atomization device. , A two-fluid spray nozzle or the like may be adopted.

Note that FIG. 1 shows the ultrafine mist 60 of the hydrogen peroxide solution supplied from the ultrafine mist supply system 20 to the inside of the isolator 10. Further, at the left end of the illustrated bottom surface inside the isolator 10 (the position farthest from the ultrafine mist supply system 20), a hydrogen peroxide gas concentration measuring device 70 for measuring the hydrogen peroxide gas concentration inside the isolator 10 is provided. It has been deployed. Further, a pair of work gloves 80 are arranged on the left wall surface of the isolator 10 in the drawing. The hydrogen peroxide gas concentration measuring device 70 and the working glove 80 are used for confirming the decontamination effect in the examples described later.

Next, the ultrafine mist supply system 20 will be described. FIG. 2 is a schematic configuration diagram of an ultrafine mist supply system as viewed from the inside of the isolator 10, and is a front view (A) and a perspective view (B). In FIG. 2, the ultrafine mist supply system 20 has a mist discharging means 30 and a convergent ultrasonic wave generating means 40. In FIG. 2, the side wall surface of the isolator 10 is omitted, and the mist discharging means 30 is clearly shown.

The mist discharging means 30 includes a preliminary mist receptor 31 and an ultrasonic atomizing device 32. The preliminary mist receptor 31 receives the preliminary mist supplied via the preliminary mist supply pipe (not shown) and separates the gas and liquid into the hydrogen peroxide solution and the air, and the air separated from the preliminary mist. Is released to the outside (detailed structure will be described later). The ultrasonic atomizer 32 converts the hydrogen peroxide solution separated by the preliminary mist receptor 31 into a fine mist 61 and discharges it into the isolator 10.

The convergent ultrasonic wave generating means 40 is composed of four vibrating discs 41a to 41d arranged on the upper part of the inner side wall surface of the isolator 10 so as to surround the discharge port of the ultrasonic atomizing device 32. Here, the distance from the discharge port of the ultrasonic atomizer 32 to each of the vibrating discs 41a to 41d is not particularly limited, but may be, for example, 0 to 200 mm, preferably about 0 to 100 mm. ..

In this embodiment, super-directional ultrasonic transmitters (DC12V, 50mA) that transmit ultrasonic waves having a frequency of around 40 kHz are used as the four vibrating discs 41a to 41d. The number of vibrating discs may be two or more, preferably three or more. Further, the type and number, size and structure, output, etc. of the ultrasonic transmitters arranged in each vibrating panel are not particularly limited. Further, in the present embodiment, the ultrasonic wave generation mechanism, frequency range, output, etc. of the ultrasonic wave transmitter are not particularly limited.

The four vibrating discs 41a to 41d that transmit super-directional ultrasonic waves have an ultrasonic acoustic flow due to ultrasonic vibration in front of the discharge axis of the discharge port of the ultrasonic atomizer 32 located at the center. The sound wave directions of each other are attached at an inward angle so as to converge. Here, the inward angle is a mounting angle such that the elevation angle of the ultrasonic acoustic flow is larger than 0 ° and smaller than 90 ° with respect to the discharge axis of the discharge port of the ultrasonic atomizer 32, and is preferable. A mounting angle that is 30 ° or more and 60 ° or less.

In the present embodiment, the four vibrating discs 41a to 41d are ultrasonically vibrated in the same phase to generate directional ultrasonic acoustic flows 42a to 42d from each disc surface in the vertical direction. Further, the wave transmission direction from each board surface is converged in front of the emission axis of the emission port of the ultrasonic atomizer 32. As a result, the ultrasonic acoustic flows 42a to 42d emitted from the vibrating discs 41a to 41d strengthen each other at the focal point 43 (converging portion 43), and the maximum energy is concentrated in this portion.

From this, the fine mist 61 of the hydrogen peroxide solution discharged into the inside of the isolator 10 from the discharge port of the ultrasonic atomizer 32 obtains the maximum energy of the concentrated acoustic flow, and is further refined. It becomes an ultrafine mist 60 of hydrogen peroxide water. Further, the energy of the converged ultrasonic acoustic flow forms the ultrafine mist 60 and promotes gasification, and further causes the ultrafine mist 60 to press the ultrasonic acoustic flow in the mist traveling direction. As a result, the ultrafine mist 60 can be dispersed and reached evenly to a distant position inside the isolator 10.

By adopting a control device (not shown), the frequency, output, and transmission time of each ultrasonic transmitter of the four vibrating discs 41a to 41d are controlled, and the ultrasonic transmission is intermittently operated or strengthened. By operating it, the pressure due to the acoustic radiation pressure acting on the ultrafine mist 60 may be changed to control the dispersion / arrival.

The ultrafine mist 60 of the hydrogen peroxide solution that has been dispersed and reached the inside of the isolator 10 has a small particle size and a large surface area, so that the evaporation efficiency of the mist is high and evaporation and condensation are actively repeated. As a result, the concentration of hydrogen peroxide gas in the ultrafine mist 60 becomes high, and a uniform and thin condensed film is formed on the inner wall surface of the isolator 10 and the outer surface of the equipment arranged inside. As a result, a high degree of decontamination environment is developed by supplying a small amount of hydrogen peroxide solution without causing unnecessary condensation on the inner wall surface of the isolator 10 and the outer surface of the internal equipment. Further, since decontamination can be efficiently performed with a small amount of hydrogen peroxide solution, the efficiency of aeration of the condensed film of the ultrafine mist 60 remaining inside the isolator 10 is improved, and the decontamination operation can be shortened.

Here, the mist discharging means 30 will be described. FIG. 3 is a front view (A) and a side sectional view (B) showing an example of a mist discharging means constituting an ultrafine mist supply system. In FIG. 3, the mist discharging means 30 is composed of a preliminary mist receptor 31 and an ultrasonic atomizing device 32.

The preliminary mist receptor 31 constitutes a space having a semi-spindle-shaped cross section inside the front surface, and an ultrasonic atomizer 32 is attached to the lower end portion of the front surface where the width of the semi-spindle shape is focused. The lower end of this internal space is narrowed in width because it has the function of a liquid reservoir 31a of a small amount of hydrogen peroxide solution separated by gas and liquid. Further, the end of the spare mist supply pipe 53a communicates with the inside of the spare mist receiver 31 at the lower end portion of the back surface of the spare mist receiver 31 (position facing the ultrasonic atomizer 32). An air vent 31b is opened at the upper end of the back surface of the preliminary mist receptor 31. A baffle plate 31c is provided between the end of the spare mist supply pipe 53a in the center of the inside of the spare mist receiver 31 and the air vent 31b.

The ultrasonic atomizer 32 includes a substantially disk-shaped porous diaphragm 32a provided with a plurality of micropores (not shown) penetrating the front and back surfaces for atomizing the gas-liquid separated hydrogen peroxide solution. It is composed of a piezoelectric vibrator 32b formed in a substantially annular plate shape that causes the porous diaphragm 32a to vibrate in a film, and a control device (not shown) for controlling the vibration of the piezoelectric vibrator 32b. The porous diaphragm 32a is attached to the piezoelectric vibrator 32b so as to cover the inner hole portion of the piezoelectric vibrator 32b.

Further, the porous diaphragm 32a is attached with its front surface facing the inside of the isolator 10 (in the left direction in the drawing) and the back surface facing the inside of the preliminary mist receptor 31, and a plurality of micropores of the porous diaphragm 32a are attached. It penetrates the inside of the isolator 10 and the inside of the reserve mist receptor 31. In FIG. 3, the surface of the porous diaphragm 32a is arranged so as to discharge the hydrogen peroxide solution mist in the horizontal direction, but the present invention is not limited to this, and the perforated diaphragm 32a is arranged downward or arranged. Depending on the position, it may be discharged upward.

In this state, the spare mist is discharged to the inside of the spare mist receptor 31 via the spare mist supply pipe 53a. Inside the spare mist receiver 31, the back surface of the porous diaphragm 32a and the end of the spare mist supply pipe 53a face each other. As a result, the released preliminary mist is directly discharged to the back surface of the porous diaphragm 32a and separated into gas and liquid. This gas-liquid separated hydrogen peroxide solution becomes fine mist (hydrogen peroxide solution mist) through a plurality of micropores of the porous diaphragm 32a that vibrates ultrasonically, and is released to the inside of the isolator 10 to remove the hydrogen peroxide solution. Demonstrates a dyeing effect.

Even if a part of the hydrogen peroxide solution separated by gas and liquid on the back surface of the porous diaphragm 32a is retained in the liquid pool 31a, these are extremely small amounts and form a plurality of micropores in the porous diaphragm 32a. It becomes a fine mist through it and is discharged into the inside of the isolator 10. On the other hand, the air separated by gas and liquid is discharged to the outside from the air vent 31b.

In this way, since the amount of hydrogen peroxide solution supplied to the ultrasonic atomizer 32 can be accurately controlled to the minimum necessary, piping over a long distance with respect to the isolator 10 in one room or a plurality of rooms to be decontaminated. Even when the above is installed, it is possible to avoid the residual hydrogen peroxide solution and perform efficient decontamination. Further, since an accurate amount of hydrogen peroxide solution mist can be supplied to the isolator 10 in this way, the hydrogen peroxide solution is deficient and the ultrasonic vibrator, which is the heart of the ultrasonic atomizer 32, fails. Never. In addition, a sufficient decontamination effect can be obtained with the minimum amount of hydrogen peroxide solution required, and the hydrogen peroxide solution can be efficiently used.

Here, the pore diameter and the number of fine pores of the porous diaphragm 32a are not particularly limited, and may be any one as long as it can secure the ultrasonic atomization effect and a sufficient supply amount of hydrogen peroxide solution mist. Normally, the pore size is about 4 to 11 μm, but if a pore size smaller than the size of the spore of the bacterium (for example, about 0.5 to 3 μm) is selected, the filter effect is exhibited and the bacteria can exert the effect. Hydrogen peroxide solution is not contaminated.

Here, the operation and effect of the ultrafine mist supply system according to the above configuration will be described by way of examples. In this example, the isolator 10 shown in FIG. 1 was used. Inside the isolator 10, the ultrafine mist supply system 20, the hydrogen peroxide gas concentration measuring device 70, and the work glove 80 are arranged at separate positions.

In this embodiment, the isolator 10 is a closed space having a volume of 4 m ³ (width 3 m × depth 1 m × height 1.3 m), and four types of decontamination tests (Example 1 and Comparative Examples 1 to 3) are performed. went. First, as Example 1 (referred to as Test X) according to the present invention, hydrogen peroxide solution (35% by weight) was supplied to the inside of the isolator 10 using the ultrafine mist supply system 20. In the test X, the preliminary mist was supplied to the mist discharging means 30 of the ultrafine mist supply system 20 by using the preliminary mist supplying means 50. The amount of hydrogen peroxide solution supplied in Test X was 12.5 g / m ³ and a decontamination time of 60 minutes (including aeration time) based on the results of the preliminary test conducted in advance.

Next, as Comparative Example 1 (this is referred to as test W), only the mist discharging means 30 of the ultrafine mist supply system 20 is used, the convergent ultrasonic generating means 40 is stopped, and the inside of the isolator 10 is peroxidized. Hydrogen peroxide water was supplied. In Test W, the preliminary mist was supplied to the mist discharging means 30 by using the preliminary mist supplying means 50 as in Example 1 (Test X). The amount of hydrogen peroxide solution supplied in Test W was 12.5 g / m ³ and a decontamination time of 60 minutes (including aeration time) as in Example 1 (Test X).

Next, as Comparative Example 2 (this is referred to as Test Y), the isolator 10 uses a conventional hydrogen peroxide gas supply device (flash evaporator) without using the ultrafine mist supply system 20. Hydrogen peroxide gas was supplied to the inside. In Test Y, hydrogen peroxide solution was supplied from the hydrogen peroxide solution tank to the hydrogen peroxide gas supply device without using the preliminary mist supply means 50. The amount of hydrogen peroxide solution supplied in Test Y was 12.5 g / m ³ and the decontamination time was 60 minutes (including the aeration time) as in Example 1 (Test X).

Next, as Comparative Example 3 (this is referred to as Test Z), a hydrogen peroxide gas supply device (flash evaporator), which is a conventional method as in Comparative Example 2 (Test Y), is used inside the isolator 10. Hydrogen peroxide solution was supplied. The amount of hydrogen peroxide solution supplied in Test Z was increased to 40.0 g / m ³ as compared with Comparative Example 2 (Test Y), and the decontamination time was also lengthened to 90 minutes (including aeration time).

In Example 1 (Test X) and Comparative Examples 1 to 3 (Tests W, Y, Z), the inside of the isolator 10 before the decontamination step is subjected to a predetermined temperature and humidity control operation before conducting an experiment. went. Further, the inside of the isolator 10 after the decontamination step was subjected to a predetermined aeration operation.

Here, the test results of the hydrogen peroxide gas concentration in Example 1 (Test X) and Comparative Examples 1 to 3 (Tests W, Y, Z) are shown. FIG. 4 is a graph showing the measurement results of the hydrogen peroxide gas concentration inside the isolator in each test of this example. In FIG. 4, when the tests X, W, and Y supplied with the same amount of hydrogen peroxide solution (12.5 g / m ³ ) are compared, the hydrogen peroxide gas concentration in Example 1 (Test X) becomes very high. You can see that there is. From this, due to the action of the convergent ultrasonic generation means 40 of the ultrafine mist supply system 20, reevaporation and condensation of the ultrafine mist and the condensed film are repeated to promote gasification, and the concentration of hydrogen peroxide gas is high. It is thought that it has become.

On the other hand, since the hydrogen peroxide gas concentration in Comparative Example 1 (Test W) forms a fine mist by the action of the ultrasonic transducer, Comparative Example 2 (Test Y) does not involve the action of the ultrasonic transducer. ), The hydrogen peroxide gas concentration is higher. However, the concentration of hydrogen peroxide gas is lower than that of Example 1 (Test X). Further, the hydrogen peroxide gas concentration in Comparative Example 2 (Test Y), which is a conventional method, is uneven and partially thick because it cannot be uniformly dispersed and reached even though it is supplied with hydrogen peroxide gas. It is considered that a condensed film is formed.

Further, the hydrogen peroxide gas concentration in Comparative Example 3 (Test Z) in which the supply amount of hydrogen peroxide solution was increased to 3 times or more was slightly higher than that of Comparative Example 1 (Test W), but the example. The value is still lower than that of 1 (test X). Further, in Comparative Example 3 (Test Z), it can be seen that the humidity inside the isolator fluctuates considerably because the supply amount of the hydrogen peroxide solution is large.

Next, the test results of the decontamination effect in Example 1 (Test X) and Comparative Examples 1 to 3 (Tests W, Y, Z) are shown. In this example, the enzyme indicator: EI (Enzyme Indicator) was attached to 12 places of the work glove 80 deployed inside the isolator 10 to confirm the decontamination effect.

Enzyme indicator: EI is to confirm the decontamination effect by fluorescently measuring the residual enzyme activity after the test, and it does not require a culture operation and confirms the decontamination effect in a short time compared to the conventional BI (Biological Indicator). Can be done. In recent years, comparative equivalence with BI has been confirmed, and it is becoming more widespread. The LRD value (Log Spore Reduction) converted from the fluorescence intensity of EI after decontamination converted into the logarithm reduction of the number of bacteria was calculated, and 4 to 6 LRD or more recognized as a sufficient decontamination effect inside the isolator was judged to be acceptable. ..

FIG. 5 shows the decontamination effect of each part of the work glove deployed inside the isolator in each test of this example, (A) the part where the enzyme indicator is attached to the work glove, and (B) the enzyme. It is a graph which shows the LRD value of an indicator. Table 1 shows the LRD values of these 12 enzyme indicators.

As can be seen from FIG. 5 and Table 1, when the LRD value of 4 to 6 LRD or more is judged to be acceptable, in Example 1 (Test X) and Comparative Example 3 (Test Z), all 12 locations are used. It reaches 4 LRD and passes, and it can be seen that the decontamination is uniform. On the other hand, the LRD values of Comparative Examples 1 and 2 (Tests W and Y) showed many insufficient decontamination regions that did not reach 4 LRD.

Comparing Example 1 (Test X) and Comparative Example 3 (Test Z) in which the decontamination effect was passed, Comparative Example 3 (Test Z) is a hydrogen peroxide solution as compared with Example 1 (Test X). The amount of hydrogen peroxide supplied is large, and the decontamination time is long. Furthermore, even when the LRD values are compared, it can be seen that Example 1 (Test X) has a larger LRD value as a whole and is efficiently decontaminated with a small amount of hydrogen peroxide solution. From these facts, it is clear that the effect of the decontamination apparatus according to the present embodiment is that the amount of hydrogen peroxide solution input is significantly reduced, and that the ultrafine mist of hydrogen peroxide solution is completely removed from the discharge port. It can be seen that it is dispersed and reached. In addition, it can be seen that the aeration time after decontamination is also shortened accordingly.

Therefore, according to the present embodiment, by making the decontamination liquid an ultrafine mist, a small amount of an appropriate amount of the decontamination liquid is supplied to the decontamination target room, and the decontamination liquid is evenly dispersed inside the decontamination target room. -Since it can be reached, it is possible to provide an ultrafine mist supply system that can achieve perfect decontamination effect, shorten work time such as aeration, and improve efficiency of decontamination work.

In carrying out the present invention, not only the above-described embodiment but also various modifications as follows can be mentioned.
(1) In the above embodiment, the preliminary mist is supplied to the mist discharging means of the ultrafine mist supply system by using the preliminary mist supplying means. However, the present invention is not limited to this, and the hydrogen peroxide solution may be directly supplied to the mist discharging means without using the preliminary mist.
(2) In the above embodiment, a plurality of vibrating discs are arranged on the upper part of the inner side wall surface of the isolator so as to surround the discharge port of the ultrasonic atomizer. However, the present invention is not limited to this, and the ultrasonic acoustic flow transmitted from the ultrasonic oscillator of each vibrating disc can be converged at the center of the mist emitted from the discharge port of the ultrasonic atomizer. All you need is.
(3) In the above embodiment, the ultrafine mist supply system is installed on the upper side wall surface of the isolator. However, it is not limited to this, and if it is possible to uniformly disperse and reach the ultrafine mist of hydrogen peroxide solution inside the decontamination target room such as an isolator, deploy it on another wall surface. You may.
(4) In the above embodiment, one ultrafine mist supply system is provided for one isolator. However, the present invention is not limited to this, and if the volume of the decontamination target chamber such as an isolator is large, a plurality of ultrafine mist supply systems may be deployed. As a result, the ultrafine mist of the hydrogen peroxide solution can be uniformly dispersed and reached inside the decontamination target chamber, and the decontamination efficiency is improved.
(5) In the above embodiment, the spare mist is supplied from one spare mist supply means to one isolator in one chamber. However, the present invention is not limited to this, and the spare mist may be supplied from one spare mist supply means to a plurality of isolators in which an ultrafine mist supply system is provided in each room.

10 ... isolator, 20 ... ultrafine mist supply system, 30 ... mist release means,
31 ... Reserve mist receptor, 31a ... Liquid pool, 31b ... Air bleeder, 31c ... Obstacle plate,
32 ... ultrasonic atomizer, 32a ... porous diaphragm, 32b ... piezoelectric vibrator,
40 ... Convergent ultrasonic generation means, 41a to 41d ... Vibration disc, 42a to 42d ... Ultrasonic acoustic flow,
43 ... Focus (convergence site), 50 ... Preliminary mist supply means, 51 ... Air compressor,
51a ... Air supply pipe, 52 ... Hydrogen peroxide water tank, 52a ... Decontamination liquid supply pipe,
52b ... Supply pump, 52c ... Weighing meter, 53 ... Ejector,
53a ... Spare mist supply piping, 60 ... Ultrafine mist, 61 ... Mist,
70 ... Hydrogen peroxide gas concentration measuring device, 80 ... Working gloves.

Claims

A mist discharging means that discharges the mist of the decontamination liquid into the decontamination target room, and the released decontamination liquid mist is made ultrafine to promote gasification, and the inside of the decontamination target room is completely filled. It has a means for generating convergent ultrasonic waves to disperse and reach.
The mist discharging means includes an ultrasonic atomizing device that converts the decontaminating liquid into fine mist and discharges it from a discharge port into the inside of the decontamination target chamber.
The convergent ultrasonic generating means is provided with a plurality of vibrating discs in the vicinity of the discharge port of the ultrasonic atomizing device, and the plurality of vibrating discs are ultrasonically vibrated in the same phase to ultrasonic waves in the vertical direction from each disc surface. The plurality of vibrating discs generate a directional ultrasonic acoustic flow due to the above, and the directing direction of each ultrasonic acoustic flow converges in front of the emission direction of the mist emitted from the emission port of the ultrasonic atomizer. By arranging
The mist discharged from the discharge port of the ultrasonic atomizer is converted into finer ultrafine mist and gasification is promoted so that the ultrafine mist reaches a position away from the discharge port. An ultra-fine mist supply system that features it.
The mist discharging means has a preliminary mist supplying means for supplying the decontaminating liquid as a preliminary mist.
The preliminary mist supply means is a gas-liquid mixture of a compressed air generator that generates compressed air, a decontamination liquid supply device that supplies the decontamination liquid, and the compressed air and the decontamination liquid to form a preliminary mist. Decontamination that communicates between the generated preliminary mist generator, the air supply pipe that communicates from the compressed air generator to the preliminary mist generator, and the decontamination liquid supply device to the preliminary mist generator. A liquid supply pipe and a spare mist supply pipe that communicates between the spare mist generator and the mist discharge means are provided.
The mist discharging means includes a spare mist receptor, and the spare mist receptor is provided with an air vent that discharges air separated from the spare mist supplied through the spare mist supply pipe to the outside.
The ultrasonic atomizer has a piezoelectric vibrator and a porous diaphragm provided with a plurality of micropores penetrating the front and back to atomize the decontamination liquid separated by gas and liquid by the vibration of the piezoelectric vibrator. The ultrafine mist supply system according to claim 1, wherein the surface of the porous diaphragm is directed to the inside of the decontamination target chamber as the discharge port.
The ultrasonic atomizer is disposed with the front surface of the porous diaphragm facing the inside of the decontamination target chamber as the discharge port and the back surface facing the inside of the preliminary mist receptor.
The spare mist supplied to the preliminary mist receiver is discharged from the preliminary mist supply pipe toward the back surface of the porous diaphragm and separated into gas and liquid, and the separated decontamination liquid is discharged from the back surface to the front surface of the porous diaphragm. The ultrafine mist supply system according to claim 1 or 2, wherein the ultrafine mist supply system is atomized and discharged from the surface of the decontamination target chamber into the inside of the decontamination target chamber.
In the ultrasonic atomizer, the front surface of the porous diaphragm is directed toward the inside of the decontamination target chamber as the discharge port, and the back surface is directed toward the liquid pool provided at the inner lower end of the preliminary mist receptor. Set up,
The preliminary mist supplied to the preliminary mist receptor is discharged from the preliminary mist supply pipe into the inside of the preliminary mist receptor and separated into gas and liquid, and the separated decontamination liquid is the liquid pool of the preliminary mist receptor. The superimposing method according to claim 1 or 2, wherein the porous diaphragm is atomized when it moves from the back surface to the front surface of the porous diaphragm and is discharged from the surface to the inside of the decontamination target chamber. Fine mist supply system.