WO2022035306A3 - Uso de colágeno-polivinilpirrolidona en la inflamación y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19) - Google Patents

Uso de colágeno-polivinilpirrolidona en la inflamación y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19) Download PDF

Info

Publication number
WO2022035306A3
WO2022035306A3 PCT/MX2021/050045 MX2021050045W WO2022035306A3 WO 2022035306 A3 WO2022035306 A3 WO 2022035306A3 MX 2021050045 W MX2021050045 W MX 2021050045W WO 2022035306 A3 WO2022035306 A3 WO 2022035306A3
Authority
WO
WIPO (PCT)
Prior art keywords
covid
days
patients
collagen
sars
Prior art date
Application number
PCT/MX2021/050045
Other languages
English (en)
French (fr)
Other versions
WO2022035306A2 (es
Inventor
Guadalupe Janette Furuzawa Carballeda
Original Assignee
Aspid S.A. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspid S.A. De C.V. filed Critical Aspid S.A. De C.V.
Priority to EP21856312.0A priority Critical patent/EP4197553A2/en
Priority to BR112023002614A priority patent/BR112023002614A2/pt
Priority to US18/021,141 priority patent/US20230285516A1/en
Priority to CA3189167A priority patent/CA3189167A1/en
Priority to CN202180064443.5A priority patent/CN116406300A/zh
Priority to PE2023000269A priority patent/PE20231052A1/es
Publication of WO2022035306A2 publication Critical patent/WO2022035306A2/es
Publication of WO2022035306A3 publication Critical patent/WO2022035306A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se relaciona con el uso de colágena polimerizada tipo I en pacientes Covid-19 positivos y a un régimen de dosificación por vía intramuscular cada 12 h durante 3 días y después cada 24 h durante 4 días en pacientes con enfermedad leve a moderada por Covid-19 o bien, a un régimen de dosificación por vía intramuscular cada 12 h durante 7 días en pacientes con enfermedad grave a semi-crítica por Covid-19. Además, se analizó la evolución clínica de cada paciente individualmente (Figuras 13 a 17 y 20 a 21) y de manera grupal (Figuras 18 y 19), tomando en cuenta los siguientes parámetros: porcentaje de SpO2, temperatura, frecuencia cardiaca, frecuencia respiratoria, intervalos de tos, dolor torácico, cefalea, disnea, odinofagia, anosmia, la pérdida del sentido del gusto, la presencia artralgias y mialgias y se documentó una mejoría clínica en todos los casos.
PCT/MX2021/050045 2020-08-12 2021-08-11 Uso de colágeno-polivinilpirrolidona en la inflamación y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19) WO2022035306A2 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP21856312.0A EP4197553A2 (en) 2020-08-12 2021-08-11 Use of collagen-polyvinylpyrrolidone in pulmonary inflammation and fibrosis in patients infected by the sars-cov2 virus (covid-19)
BR112023002614A BR112023002614A2 (pt) 2020-08-12 2021-08-11 Uso de colágeno-polivinilpirrolidona na inflamação e fibrose pulmonar em pacientes infectados pelo vírus sars-cov2 (covid-19)
US18/021,141 US20230285516A1 (en) 2020-08-12 2021-08-11 Use of collagen-polyvinylpyrrolidone in pulmonary inflammation and fibrosis in patients infected by the sars-cov2 virus (covid-19)
CA3189167A CA3189167A1 (en) 2020-08-12 2021-08-11 Use of collagen-polyvinylpyrrolidone in pulmonary inflammation and fibrosis in patients infected by the sars-cov2 virus (covid-19)
CN202180064443.5A CN116406300A (zh) 2020-08-12 2021-08-11 胶原蛋白-聚乙烯吡咯烷酮在由SARS-CoV2病毒(Covid-19)感染的患者肺部炎症和纤维化中的用途
PE2023000269A PE20231052A1 (es) 2020-08-12 2021-08-11 Uso de colageno-polivinilpirrolidona en la inflamacion y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2020008473A MX2020008473A (es) 2020-08-12 2020-08-12 Uso de colageno-polivinilpirrolidona en la inflamacion y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19).
MXMX/A/2020/008473 2020-08-12

Publications (2)

Publication Number Publication Date
WO2022035306A2 WO2022035306A2 (es) 2022-02-17
WO2022035306A3 true WO2022035306A3 (es) 2022-04-28

Family

ID=80247247

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2021/050045 WO2022035306A2 (es) 2020-08-12 2021-08-11 Uso de colágeno-polivinilpirrolidona en la inflamación y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19)

Country Status (9)

Country Link
US (1) US20230285516A1 (es)
EP (1) EP4197553A2 (es)
CN (1) CN116406300A (es)
BR (1) BR112023002614A2 (es)
CA (1) CA3189167A1 (es)
CL (1) CL2023000422A1 (es)
MX (1) MX2020008473A (es)
PE (1) PE20231052A1 (es)
WO (1) WO2022035306A2 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172445A1 (en) * 2004-05-27 2007-07-26 Aspid S.S. De C.A. Chronic articular inflammation-modulating composition based on collagen-polyvinylpyrrolidone
US20150232842A1 (en) * 2007-12-21 2015-08-20 Coda Therapeutics, Inc. Treatment of fibrotic conditions
WO2021229577A1 (en) * 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172445A1 (en) * 2004-05-27 2007-07-26 Aspid S.S. De C.A. Chronic articular inflammation-modulating composition based on collagen-polyvinylpyrrolidone
US20150232842A1 (en) * 2007-12-21 2015-08-20 Coda Therapeutics, Inc. Treatment of fibrotic conditions
WO2021229577A1 (en) * 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JANETTE FURUZAWA CARBALLEDA: "Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients", CLINICALTRIALS.GOV, 18 August 2020 (2020-08-18), XP009543175, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/show/NCT04517162> *
SANCHEZ-POZOS ET AL.: "Polymerized type I collagen reduces chronic cyclosporine nephrotoxicity", NEPHROL DIAL TRANSPLANT, vol. 25, 2010, pages 2150 - 2158, XP055926412 *

Also Published As

Publication number Publication date
CA3189167A1 (en) 2022-02-17
WO2022035306A2 (es) 2022-02-17
CN116406300A (zh) 2023-07-07
CL2023000422A1 (es) 2023-09-15
PE20231052A1 (es) 2023-07-11
US20230285516A1 (en) 2023-09-14
BR112023002614A2 (pt) 2023-05-09
EP4197553A2 (en) 2023-06-21
MX2020008473A (es) 2022-02-14

Similar Documents

Publication Publication Date Title
CN107307312A (zh) 一种五香卤猪蹄及其制作方法
Riley et al. Antibiotic susceptibility of clinical isolates of Campylobacter jejuni and Campylobacter coli in Ontario, Canada during 2011–2013
WO2022035306A3 (es) Uso de colágeno-polivinilpirrolidona en la inflamación y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19)
RU2735723C1 (ru) Технология реабилитационно-профилактической нутритивной поддержки при коронавирусной инфекции
Gowd et al. Isolated myocardial bridging and exercise-related cardiac events
Straube et al. In vitro influence of d/l-lactic acid, sodium chloride and sodium nitrite on the infectivity of feline calicivirus and of ECHO virus as potential surrogates for foodborne viruses
Kushkestani et al. Physical activity is a preventive factor against SARS-CoV-2 in healthy subjects (possible cellular and molecular mechanisms)
Knapp et al. Effects of adenosine monophosphate on induction of therapeutic hypothermia and neuronal damage after cardiopulmonary resuscitation in rats
Durrance et al. Chagas cardiomyopathy presenting as symptomatic bradycardia: an underappreciated emerging public health problem in the United States
CN112641872A (zh) 用于清热解毒、防治疫病的药食同源组合物
Navi et al. Nonlinear effect of changing the temperature to overcome Covid-19
Noe et al. Optimization of vaccine production for animal health
CN106993760A (zh) 一种低盐低硝酱猪蹄及其制备方法
Flato et al. 10D: Feasibility Study of a Novel Low-cost Brazilian Emergency Mechanical Ventilator
Alves ENDOCARDITE E MIOCARDITE BACTERIANAS EM CADELA-RELATO DE CASO
Rohani Recurrent Chest Pain and Lytic Lesion in the Spine
Valijon o’g’li CHANGES IN THE CIRCULATORY SYSTEM AFTER COVID-19
Saqib et al. Immune boosters to combat zoonotic viral diseases
Jayasekara et al. Wellens Syndrome; an ominous ECG feature that should not be missed–2 case reports
Narab et al. COVID-19 outcomes in patients with heart diseases
Burgos et al. Infective Endocarditis in Argentina: What have we learn in the last 25 years?
Abuzaid Respiratory failure secondary to pulmonary toxicity: case report
Savale Interferon-β
Abdulayeva et al. Сovid-19 and its features
Yan-bo et al. Dextrocardia with Cor Biloculare in a 44 Year Old Women

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21856312

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 3189167

Country of ref document: CA

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112023002614

Country of ref document: BR

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2021856312

Country of ref document: EP

Effective date: 20230313

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21856312

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 112023002614

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20230210