WO2022030883A1 - Composition for teeth whitening and method of preparing same - Google Patents

Composition for teeth whitening and method of preparing same Download PDF

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WO2022030883A1
WO2022030883A1 PCT/KR2021/009914 KR2021009914W WO2022030883A1 WO 2022030883 A1 WO2022030883 A1 WO 2022030883A1 KR 2021009914 W KR2021009914 W KR 2021009914W WO 2022030883 A1 WO2022030883 A1 WO 2022030883A1
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Prior art keywords
tooth whitening
composition
calcium silicate
hydrated calcium
tooth
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PCT/KR2021/009914
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French (fr)
Korean (ko)
Inventor
김광만
권재성
양송이
최지원
Original Assignee
연세대학교 산학협력단
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Publication of WO2022030883A1 publication Critical patent/WO2022030883A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/152—Hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/1564—Aluminium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/1592—Iron
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/1624—Sulphur
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/1628—Silicium

Definitions

  • the present invention relates to a composition for whitening teeth and a method for preparing the same, and more particularly, to a composition for whitening teeth and a method for preparing the same for preventing a decrease in tooth hardness due to a tooth whitening treatment.
  • Teeth whitening may refer to a treatment that uses a material having a whitening function to make colored or discolored hemorrhoids brighter, whiter, and transparent to their original color tone or more.
  • the mechanism of teeth whitening is that the oxygen that is released as the tooth whitening active material such as 'hydrogen peroxide' or 'carbamide peroxide' is decomposed on the surface or inner surface of the tooth enters the enamel and dentin and becomes colored. Bleaching a substance to make teeth whiter and brighter.
  • the new tooth whitening agent containing calcium agents may still have limitations in that it does not prevent the low pH environment caused by the bleaching reaction of teeth.
  • the inventors of the present invention have tried to research and develop a dental material that provides a tooth whitening effect and at the same time maintains the pH level at a level with little damage to the teeth to prevent a decrease in tooth hardness.
  • the inventors of the present invention paid attention to calcium silicate having excellent biocompatibility, and when it was used together with a tooth whitening active material, it was confirmed that the problem of using the tooth whitening active material alone while providing a whitening effect was solved. .
  • the inventors of the present invention have found that when white Portland cement is hydrated, calcium hydroxide is produced, and when calcium hydroxide and water meet, calcium and hydroxide ions are formed to compensate for hypersensitivity, which is a side effect of whitening agents, and to obtain a remineralization effect due to calcium. was able to confirm that
  • the inventors of the present invention with respect to the composition for teeth whitening to which hydrated calcium silicate is added, it was confirmed that the effect of blocking the decrease in pH by maintaining the pH level of the composition for whitening teeth in neutral is improved.
  • the inventors of the present invention satisfy the condition that the decrease in Vickers surface hardness after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization, is less than 10 for the tooth whitening composition to which hydrated calcium silicate is added.
  • the inventors of the present invention have confirmed that, with respect to the tooth whitening composition to which hydrated calcium silicate is added, the microhardness of the enamel surface does not decrease, and thus has an effect of blocking tooth demineralization.
  • the inventors of the present invention have developed a new composition for whitening teeth effective for whitening teeth while supplementing the limitations of conventional tooth whitening agents made of active tooth whitening materials by providing a new composition for whitening teeth.
  • an object of the present invention is to provide a composition for whitening teeth, including calcium silicate and an active material for whitening teeth.
  • Another object to be solved by the present invention is to provide a method for preparing a composition for whitening teeth.
  • Another object to be solved by the present invention is to provide a tooth whitening functional food, toothpaste, and mouthwash containing a tooth whitening composition as an active ingredient.
  • a tooth whitening composition comprising hydrated calcium silicate and a tooth whitening active material.
  • hydrated calcium silicate may refer to a water-containing product formed by combining calcium silicate with water.
  • the hydrated calcium silicate may be hydrated white Portland cement.
  • the hydrated calcium silicate can prevent a decrease in the microhardness of the tooth surface due to the bleaching reaction of the tooth that occurs when the tooth whitening active material is used alone.
  • the microhardness of the surface of the enamel treated with the composition for teeth whitening according to an embodiment of the present invention may be 1.1 times to 1.5 times that of the surface microhardness of teeth not treated with the composition for teeth whitening. have.
  • the composition for whitening teeth according to an embodiment of the present invention may have a pH level of 6.5 to 7.5. That is, the composition for whitening teeth is close to neutral, so that it is possible to prevent a decrease in surface microhardness due to a decrease in pH of teeth during teeth whitening.
  • the brightness of the tooth whitening composition according to an embodiment of the present invention may be 1.1 times to 1.5 times the brightness of teeth treated with the tooth whitening composition containing only the tooth whitening active material.
  • composition for whitening teeth according to various embodiments of the present invention may not only prevent a decrease in surface micro hardness, but also satisfy the degree required by international standards.
  • the tooth whitening composition according to an embodiment of the present invention may be provided as a tooth whitening functional toothpaste, a teeth whitening functional mouthwash, a teeth whitening functional food, and the like.
  • the hydrated calcium silicate may further include at least one element of iron, aluminum, magnesium and sulfur, along with calcium and silicon.
  • These elements may be associated with the activity of hydrated calcium silicate.
  • the hydrated calcium silicate may include both iron, aluminum, magnesium and sulfur, along with calcium and silicon.
  • the calcium content may be 65 to 75 wt% based on the total weight of the hydrated calcium silicate
  • the silicon content may be 13 to 19 wt% based on the total weight of the hydrated calcium silicate.
  • the content of iron may be 3 to 7 wt% based on the total weight of the hydrated calcium silicate
  • the content of aluminum may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate
  • magnesium The content may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate.
  • the content of sulfur may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate.
  • the particle diameter of the hydrated calcium silicate may be 2 to 3 ⁇ m.
  • the present invention is not limited thereto.
  • the content of hydrated calcium silicate may be 0.001 to 5 wt% based on the total weight of the composition for whitening teeth.
  • the content of hydrated calcium silicate may be 0.25 to 2 wt% based on the total weight of the composition for whitening teeth. More preferably, in the composition for whitening teeth, the content of hydrated calcium silicate may be 0.5 to 1.5 wt% based on the total weight of the composition for whitening teeth. Even more preferably, in the tooth whitening composition, the content of hydrated calcium silicate may be 0.7 to 1.25 wt% based on the total weight of the tooth whitening composition, but is not limited thereto.
  • tooth whitening active material may refer to a material that decomposes on the surface or inner surface of a tooth to generate oxygen, and bleaches a colored material to provide a tooth whitening effect.
  • the tooth whitening active material is hydrogen peroxide, calcium peroxide, carbamide peroxide, peroxy acid, peroxycarbonate, peroxysulfate, urea peroxide, peroxyborate, metal chlorite, peroxide It may be at least one of sodium pyrophosphate and sodium peroxide.
  • the tooth whitening active material may be hydrogen peroxide, more preferably, the tooth whitening active material may be 35% hydrogen peroxide.
  • the present invention is not limited thereto.
  • the content of the tooth whitening active material in the tooth whitening composition, may be 95 to 99.999 wt% based on the total weight of the tooth whitening composition.
  • the content of the tooth whitening active material may be 98 to 99.75 wt% based on the total weight of the tooth whitening composition.
  • the content of the tooth whitening active material may be 98.5 to 99.5 wt% based on the total weight of the tooth whitening composition.
  • the content of the tooth whitening active material may be 98.75 to 99.3 wt% based on the total weight of the tooth whitening composition, but is not limited thereto.
  • a method for preparing a composition for teeth whitening comprising the steps of preparing hydrated calcium silicate, and mixing the hydrated calcium silicate and a tooth whitening active material to obtain a composition for teeth whitening.
  • the hydrated calcium silicate may further include at least one of iron, aluminum, magnesium, and sulfur.
  • step of preparing hydrated calcium silicate to obtain a mixture, to mix calcium silicate and water, to obtain a solid mixture, to harden the mixture, to obtain a hydrated calcium silicate powder;
  • a step of grinding the solid mixture may be performed.
  • a step of mixing the hydrated calcium silicate and the tooth whitening active material in a weight ratio of 0.0001:99.9999 to 5:95 may be performed.
  • a tooth whitening functional food comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
  • the tooth whitening functional food may be provided in the form of at least one of gum, candy, candy, jelly, and caramel.
  • a tooth whitening functional toothpaste comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
  • a tooth whitening functional mouthwash comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
  • the present invention provides a tooth whitening composition comprising calcium silicate and a tooth whitening active material, thereby overcoming the limitations of the conventional tooth whitening composition comprising only a tooth whitening active material such as hydrogen peroxide.
  • the present invention can overcome the limitations of the conventional composition for whitening teeth in which tooth hardness decreases due to the tooth bleaching process by failing to prevent the low pH environment caused by the bleaching reaction of teeth.
  • the present invention provides hydrated calcium silicate together with a tooth whitening active material, it provides a whitening effect while providing a fine hardness of the enamel surface that is superior to that when the tooth whitening active material is used alone, and prevents tooth demineralization.
  • the present invention may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization.
  • the present invention can provide an effective amount of each composition in the composition for whitening teeth, while maintaining the effectiveness as a composition for whitening teeth, preventing loss of fine enamel surface hardness and blocking tooth demineralization.
  • the present invention may be provided as a tooth whitening functional food composition, toothpaste, mouthwash, and the like according to the above-described activity.
  • the effect according to the present invention is not limited by the contents exemplified above, and more various effects are included in the present specification.
  • FIG. 1 exemplarily shows a method for preparing a tooth whitening composition according to an embodiment of the present invention.
  • 2A and 2B show the results of elemental analysis of hydrated calcium silicate used in various examples of the present invention.
  • 2C shows the particle morphology of hydrated calcium silicate used in various embodiments of the present invention.
  • 5A to 5C are results showing changes in tooth brightness according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
  • 6a and 6b are results showing the tooth surface microhardness level according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
  • FIG. 1 exemplarily shows a method for preparing a tooth whitening composition according to an embodiment of the present invention.
  • the tooth whitening composition of the present invention may be prepared by preparing hydrated calcium silicate (S110), and mixing hydrated calcium silicate and a tooth whitening active material (S120).
  • hydrated white Portland cement may be used as the hydrated calcium silicate.
  • the hydrated calcium silicate may further include at least one of iron, aluminum, magnesium and sulfur as a constituent element.
  • the calcium silicate and water are mixed and then cured, and the solid mixture is pulverized to obtain a hydrated calcium silicate powder.
  • hydrated calcium silicate For example, in the step of preparing hydrated calcium silicate (S110), white Portland cement is hand mixed with distilled water at a ratio of 0.33 (water/powder) for 1 minute on a glass plate using a plastic spatula. have. Then, the mixture can be cured for 3 days at 37 ⁇ 1°C and 100% relative humidity. The cured solid mixture may be milled at 450 rpm for 40 minutes with a ball mill, and then filtered with a 400-mesh sieve shaker. As a result of the step (S110) in which the hydrated calcium silicate is prepared, a hydrated calcium silicate powder having an average particle size of 2.465 ⁇ m can be prepared.
  • the method for obtaining the hydrated calcium silicate is not limited to the above.
  • the hydrated calcium silicate and the tooth whitening active material are mixed to obtain a tooth whitening composition.
  • the tooth whitening active material may be hydrogen peroxide. More preferably, the tooth whitening active material may be, but is not limited to, 35% hydrogen peroxide.
  • the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.0001:99.9999 to 5:95.
  • the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.25:99.75 to 2:98.
  • the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.5:99.5 to 1.5:98.5.
  • the composition for whitening teeth to which hydrated calcium silicate is added obtained by the step (S120) of mixing the hydrated calcium silicate and the tooth whitening active material, provides a whitening effect, while providing a whitening effect with more enamel than when the tooth whitening active material is used alone. It has excellent surface hardness and can block tooth demineralization.
  • the composition for whitening teeth to which hydrated calcium silicate is added may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent prescribed by the International Standards Organization.
  • FIGS. 2A and 2B show the results of elemental analysis of hydrated calcium silicate used in various examples of the present invention.
  • Figure 2c shows the particle morphology of hydrated calcium silicate used in various embodiments of the present invention.
  • the hydrated calcium silicate powder consists of calcium (Ca), silicon (Si), iron (F), aluminum (Al), magnesium (Mg) and sulfur (S), with calcium being the most It appears to contain a lot. Then, 16.05 wt% of silicon, 5.53 wt% of iron, 3.53 wt% of aluminum, 2.16 wt% of magnesium, and 2.04 wt% of sulfur are shown.
  • hydrated calcium silicate may be present in an amount of 65 to 75 wt % calcium based on the total weight of the hydrated calcium silicate, 13 to 19 wt % of silicon with respect to the total weight of the hydrated calcium silicate, iron, aluminum, magnesium and at least one element of sulfur.
  • the hydrated calcium silicate containing the above components may provide an effect of improving the microhardness of the enamel surface along with a whitening effect and blocking tooth demineralization.
  • a Scanning Electron Microscope (SEM) image at 2,000 magnification of hydrated calcium silicate particles is shown.
  • the size of the hydrated calcium silicate particles may be about 2.465 ⁇ m.
  • Hydrated calcium silicate having such structural properties may form calcium ions and hydroxide ions when reacted with water.
  • the pH can remain neutral, so hypersensitivity, which is a side effect of the tooth whitening agent, can be supplemented, and the remineralization effect due to calcium can appear. Accordingly, it may be provided as a component of the tooth whitening composition according to various embodiments of the present invention.
  • the tooth whitening active substance is selected from among calcium peroxide, carbamide peroxide, peroxyacid, peroxycarbonate, peroxysulfate, urea peroxide, peroxyborate, metal chlorite, sodium peroxypyrophosphate and sodium peroxide. It may be at least one, and may have a level of activity similar to that of using hydrated calcium silicate and hydrogen peroxide as the tooth whitening active material.
  • hCS0.25 composed of 99.75 wt% of hydrogen peroxide and 0.25 wt% of hydrated calcium silicate (hCS)
  • hCS0.50 composed of 99.50 wt% of hydrogen peroxide and 0.50 wt% of hydrated calcium silicate
  • 99.00 wt% of hydrogen peroxide and Experimental groups were established of hCS1.00 consisting of 1.00 wt % of hydrated calcium silicate
  • hCS2.00 consisting of 98.00 wt % of hydrogen peroxide and 2.00 wt % of hydrated calcium silicate.
  • each experimental group of hCS0.25, hCS0.50, hCS1.00 and hCS2.00 was vortexed for 10 seconds to homogenize, and in order to analyze the pH of each solution, the mixtures of the experimental group were mixed immediately before measurement. After mixing for 10 seconds, the pH value was measured immediately using a pH meter. At this time, the pH measurement was performed at 1 minute intervals for 15 minutes.
  • the control group consisting only of hydrogen peroxide has a pH value of 2.24 ⁇ 0.03 starting at 2.17 ⁇ 0.10 after 15 minutes, which is lower than that of other experimental groups.
  • hCS0.25 containing hydrated calcium silicate showed a pH value of 6.84 ⁇ 0.02 after 10 seconds of preparation, a pH value of 6.95 ⁇ 0.07 after 15 minutes, and hCS0.50 had a pH value of 10 seconds after preparation. After this 7.06 ⁇ 0.01, the pH value after 15 minutes appears to be 7.35 ⁇ 0.02.
  • hCS1.00 has a pH value of 7.27 ⁇ 0.04 after 10 seconds of manufacture and 7.78 ⁇ 0.03 after 15 minutes
  • hCS2.00 has a pH value of 7.52 ⁇ 0.05 after 10 seconds of manufacture and a pH value of 15 minutes after 8.05 ⁇ 0.02, which is the highest. That is, the pH of the tooth whitening composition containing the hydrated calcium silicate appears as a value close to neutral. In this case, the neutral tooth whitening composition containing hydrated calcium silicate forms hydroxide ions in the tooth whitening process to prevent a decrease in pH, and maintains the pH neutral to prevent damage to teeth.
  • the composition for whitening teeth according to various embodiments of the present invention containing hydrated calcium silicate maintains a neutral pH, in contrast to the control composition containing only hydrogen peroxide. Accordingly, the composition for whitening teeth according to various embodiments of the present invention can prevent hypersensitivity, which is a side effect of the tooth whitening agent, as well as provide a remineralization effect due to calcium.
  • Evaluation 3 Teeth whitening effect treated with the tooth whitening composition according to various embodiments of the present invention
  • the specimen was immersed in a staining solution in order to proceed with a process of making a certain color before applying the tooth whitening composition according to various embodiments of the present invention, and a relative humidity of 100 at 37 ⁇ 1° C. % was stored for 3 days.
  • the coloring solution was changed to a new solution every 24 hours. After 3 days, the specimens were washed with distilled water and dried.
  • a tooth whitening composition of hCS0.25, hCS0.50, hCS1.00, and hCS2.00 was prepared immediately before the whitening treatment, mixed for 10 seconds, and then treated with 100 ⁇ l of each specimen. Thereafter, the specimen was stored for 15 minutes at 100% relative humidity of 37 ⁇ 1° C., washed with distilled water, and dried. This process was repeated a total of 3 times and the specimen was exposed to the tooth whitening composition for a total of 45 minutes.
  • the specimen treated with the tooth whitening composition according to various embodiments of the present invention was placed in a 3 mm measurement window using a spectrophotometer, and the brightness of the three parts for the specimen was randomly placed. (L*) and chroma (a*, b*) were measured. At this time, the average values of brightness and saturation were set as representative values. Then, based on the representative values, ⁇ E* corresponding to the degree of whitening was calculated according to the following equation (1).
  • L before is the brightness of the specimen before treatment with the composition for teeth whitening according to various embodiments of the present invention
  • L after is the brightness of the specimen after treatment with the composition for teeth whitening according to various embodiments of the present invention.
  • a before and b before are the saturation of the specimen before treatment with the tooth whitening composition according to various embodiments of the present invention
  • a after and b after is the saturation of the specimen after treatment with the tooth whitening composition according to various embodiments of the present invention.
  • ⁇ L* may mean the degree of white and black.
  • ⁇ a* may indicate the degree of red and green
  • ⁇ b* may indicate the degree of yellow and blue.
  • 5A to 5C are results showing changes in tooth brightness according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
  • ⁇ L* of the specimen increased appears to be Furthermore, referring to FIGS. 5B and 5C , according to the treatment of the tooth whitening composition according to various embodiments of the present invention, ⁇ b* of the specimen is decreased. This may mean that there is a whitening effect on the colored specimen.
  • the composition for teeth whitening according to various embodiments of the present invention containing hydrated calcium silicate provides a tooth whitening effect superior to the control composition for teeth whitening containing only hydrogen peroxide.
  • Evaluation 4 Effect of increasing the surface microhardness of teeth treated with the tooth whitening composition according to various embodiments of the present invention
  • the tooth whitening compositions of hCS0.25, hCS0.50, hCS1.00, and hCS2.00 were prepared in the same manner as in the above evaluation 3 with respect to the specimen manufactured by the same method as the method of evaluation 3 described above. has been processed Then, using a Vickers hardness tester (Vickers hardness tester) with a load of 0.49N for 15 seconds, the microhardness was randomly measured for 4 parts of the specimen. At this time, the average value was set as the representative value. Then, based on the measured value, a percentage of micro hardness loss ( ⁇ PML) was determined according to Equation 2 below.
  • ⁇ PML micro hardness loss
  • the fine hardness loss rate ( ⁇ PML) was 16.43 ⁇ 3.90 in the hydrogen peroxide control group, indicating that higher hardness loss occurred compared to other experimental groups.
  • the microhardness loss rate of hCS0.50 is -9.42 ⁇ 2.62
  • the microhardness loss rate of hCS1.00 is -20.11 ⁇ 3.80
  • the microhardness loss rate of hCS2.00 is -19.27 ⁇ 2.76. That is, these experimental results may mean that, in the case of the added composition of hydrated calcium silicate, the tooth whitening effect and the hardness of the tooth surface did not decrease at the same time.
  • composition for whitening teeth according to various embodiments of the present invention in relation to tooth whitening and improvement of tooth microhardness, is 0.75 to 2.25 wt%, preferably 0.1 to 2 wt% of hydrated calcium silicate based on the weight of the total composition may contain, but is not limited thereto.
  • the tooth whitening composition according to various embodiments of the present invention containing hydrated calcium silicate not only prevents loss of surface microhardness of teeth during tooth whitening, but also increases surface microhardness.
  • the composition for whitening teeth according to various embodiments of the present invention not only provides an excellent tooth whitening effect as the composition for teeth whitening containing only hydrogen peroxide of the control group, but also provides non-deteriorating or enhanced tooth surface microhardness. have.
  • the enamel surface of the control group showed a demineralized aspect when compared with the healthy dentate enamel surface (non-treatment).
  • the enamel surfaces of the experimental groups, hCS1.00 and hCS2.00 appeared to maintain a similar morphology without demineralization when compared to the healthy dentate enamel surface.
  • the tooth whitening composition according to various embodiments of the present invention containing hydrated calcium silicate prevents damage to the enamel surface during teeth whitening. That is, the tooth whitening composition according to various embodiments of the present invention can prevent enamel surface damage while providing a tooth whitening effect, in contrast to the tooth whitening composition containing only hydrogen peroxide, which causes enamel surface damage according to tooth whitening. there is an effect
  • the present invention can overcome the limitations of the conventional tooth whitening composition in which a decrease in hardness of the enamel surface due to the tooth bleaching process occurs because the low pH environment caused by the bleaching reaction of the tooth cannot be prevented.
  • the microhardness of the enamel surface is superior to when the tooth whitening active material is used alone while providing a whitening effect, and tooth demineralization can be prevented have.
  • the present invention may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization.
  • the present invention can provide an effective amount of each composition in the composition for whitening teeth, while maintaining the effectiveness as a composition for whitening teeth, preventing loss of surface microhardness and preventing tooth demineralization.

Abstract

Provided in the present specification are a composition for teeth whitening, which comprises calcium silicate and a composition for teeth whitening as active ingredients, and a teeth whitening agent composition.

Description

치아 미백용 조성물 및 이의 제조 방법Composition for whitening teeth and method for preparing the same
본 발명은 치아 미백용 조성물 및 이의 제조 방법에 관한 것으로, 보다 구체적으로 치아 미백 처리에 따른 치아 경도 저하를 예방하기 위한 치아 미백용 조성물 및 이의 제조 방법에 관한 것이다.The present invention relates to a composition for whitening teeth and a method for preparing the same, and more particularly, to a composition for whitening teeth and a method for preparing the same for preventing a decrease in tooth hardness due to a tooth whitening treatment.
치아 미백이란, 미백 기능이 있는 물질을 이용하여 착색 또는 변색된 치질을 원래의 색조로 또는 그 이상으로 밝고, 희고, 투명하게 만들어 주는 처치를 의미할 수 있다. Teeth whitening may refer to a treatment that uses a material having a whitening function to make colored or discolored hemorrhoids brighter, whiter, and transparent to their original color tone or more.
이때, 치아 미백의 기전은 '과산화수소 (hydrogen peroxide)' 혹은 '카바마이드퍼옥사이드 (carbamide peroxide)' 등의 치아 미백 활성 물질이 치아 표면 혹은 내면에서 분해되면서 방출하는 산소가 법랑질과 상아질 내로 들어가 착색된 물질을 표백하여 치아를 희고 밝게 만드는 것이다. At this time, the mechanism of teeth whitening is that the oxygen that is released as the tooth whitening active material such as 'hydrogen peroxide' or 'carbamide peroxide' is decomposed on the surface or inner surface of the tooth enters the enamel and dentin and becomes colored. Bleaching a substance to make teeth whiter and brighter.
한편, 고 농도의 치아 미백 활성 물질을 이용한 치아 미백 시, 미백 효과의 발현은 빠르지만 낮아지는 pH로 인해 치아 표면의 경도 감소, 탈회, 지각과민 (hyperesthesia) 발생 등의 부작용이 있을 수 있다. On the other hand, when whitening teeth using a high concentration of a tooth whitening active material, the expression of the whitening effect is rapid, but there may be side effects such as a decrease in the hardness of the tooth surface, demineralization, and the occurrence of hyperesthesia due to the lowering pH.
이상의 문제점을 해결하기 위해, 치아 경도 저하를 예방하고, 치아 미백 효과를 제공하는, 새로운 치아 미백용 조성물의 개발이 지속적으로 요구되고 있는 실정이다. In order to solve the above problems, there is a continuous need for the development of a new composition for whitening teeth, which prevents deterioration of tooth hardness and provides a tooth whitening effect.
발명의 배경이 되는 기술은 본 발명에 대한 이해를 보다 용이하게 하기 위해 작성되었다. 발명의 배경이 되는 기술에 기재된 사항들이 선행기술로 존재한다고 인정하는 것으로 이해되어서는 안 된다.The description underlying the invention has been prepared to facilitate understanding of the invention. It is not to be construed as an admission that the matters described in the background technology of the invention exist as prior art.
한편, 종래의 치아 미백제의 한계점을 극복하기 위한 방안으로, 과산화수소에 칼슘 제제들을 첨가한 새로운 치아 미백제가 제안되었다. 그러나, 칼슘 제제들을 첨가한 새로운 치아 미백제는, 여전히 치아의 표백 반응에 따른 낮은 pH 환경을 막지 못한다는 점에서 한계가 있을 수 있다.On the other hand, as a way to overcome the limitations of conventional tooth whitening agents, a new tooth whitening agent in which calcium agents are added to hydrogen peroxide has been proposed. However, the new tooth whitening agent containing calcium agents may still have limitations in that it does not prevent the low pH environment caused by the bleaching reaction of teeth.
본 발명의 발명자들은, 이를 해결하기 위한 방안으로, 치아 미백 효과를 제공하는 것과 동시에 pH수준을 치아의 손상이 적은 수준으로 유지하여 치아 경도 저하를 예방하는 치과용 물질에 대하여 연구 개발하고자 하였다.As a solution to this problem, the inventors of the present invention have tried to research and develop a dental material that provides a tooth whitening effect and at the same time maintains the pH level at a level with little damage to the teeth to prevent a decrease in tooth hardness.
본 발명의 발명자들은, 생체 적합성이 뛰어난 칼슘 실리케이트에 주목하였고, 이를 치아 미백 활성 물질과 함께 이용할 경우, 미백 효과를 제공하면서 치아 미백 활성 물질을 단독으로 이용했을 때의 문제점이 해결되는 것을 확인할 수 있었다. The inventors of the present invention paid attention to calcium silicate having excellent biocompatibility, and when it was used together with a tooth whitening active material, it was confirmed that the problem of using the tooth whitening active material alone while providing a whitening effect was solved. .
특히, 본 발명의 발명자들은 백색 포틀랜드 시멘트를 수화할 경우, 수산화칼슘이 생성되고, 이 수산화칼슘과 물이 만나면 칼슘과 수산화이온이 형성되어 미백제의 부작용인 지각과민증을 보완하면서 칼슘으로 인한 재광화 효과까지 얻을 수 있음을 확인할 수 있었다. In particular, the inventors of the present invention have found that when white Portland cement is hydrated, calcium hydroxide is produced, and when calcium hydroxide and water meet, calcium and hydroxide ions are formed to compensate for hypersensitivity, which is a side effect of whitening agents, and to obtain a remineralization effect due to calcium. was able to confirm that
보다 구체적으로, 본 발명의 발명자들은, 수화된 칼슘 실리케이트가 첨가된 치아 미백용 조성물에 대하여, 치아 미백용 조성물의 pH 수준을 중성에 유지하여 pH 저감을 차단하는 효과가 향상된 것을 확인할 수 있었다.More specifically, the inventors of the present invention, with respect to the composition for teeth whitening to which hydrated calcium silicate is added, it was confirmed that the effect of blocking the decrease in pH by maintaining the pH level of the composition for whitening teeth in neutral is improved.
이때, 본 발명의 발명자들은 수화된 칼슘 실리케이트가 첨가된 치아 미백용 조성물에 대하여, 국제 표준 기구에서 규정한 치아 미백제의 필요 조건인, 치아 미백용 조성물 처치 후 비커스 표면 경도 감소가 10 미만인 조건을 만족하는 것을 인지할 수 있었다.At this time, the inventors of the present invention satisfy the condition that the decrease in Vickers surface hardness after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization, is less than 10 for the tooth whitening composition to which hydrated calcium silicate is added. could recognize that
특히, 본 발명의 발명자들은 수화된 칼슘 실리케이트가 첨가된 치아 미백용 조성물에 대하여, 법랑질 표면의 미세 경도가 감소하지 않으며, 이에 따른 치아 탈회의 차단 효과가 있음을 확인할 수 있었다.In particular, the inventors of the present invention have confirmed that, with respect to the tooth whitening composition to which hydrated calcium silicate is added, the microhardness of the enamel surface does not decrease, and thus has an effect of blocking tooth demineralization.
이에, 본 발명의 발명자들은, 새로운 치아 미백용 조성물을 제공함으로써, 종래의 치아 미백 활성 물질로 이루어진 치아 미백제의 한계점을 보완하면서, 치아 미백에 효과적인 새로운 치아 미백용 조성물을 개발하기에 이르렀다.Accordingly, the inventors of the present invention have developed a new composition for whitening teeth effective for whitening teeth while supplementing the limitations of conventional tooth whitening agents made of active tooth whitening materials by providing a new composition for whitening teeth.
이에, 본 발명이 해결하고자 하는 과제는, 칼슘 실리케이트 및 치아 미백 활성 물질을 포함하는, 치아 미백용 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide a composition for whitening teeth, including calcium silicate and an active material for whitening teeth.
본 발명이 해결하고자 하는 다른 과제는, 치아 미백용 조성물의 제조 방법을 제공하는 것이다. Another object to be solved by the present invention is to provide a method for preparing a composition for whitening teeth.
본 발명이 해결하고자 하는 다른 과제는, 치아 미백용 조성물을 유효 성분으로 포함하는, 치아 미백 기능성 식품, 치약 및 구강 청결제를 제공하는 것이다. Another object to be solved by the present invention is to provide a tooth whitening functional food, toothpaste, and mouthwash containing a tooth whitening composition as an active ingredient.
본 발명의 과제들은 이상에서 언급한 과제들로 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.The problems of the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.
본 발명의 일 실시예에 따르면, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질을 포함하는, 치아 미백용 조성물이 제공된다.According to one embodiment of the present invention, there is provided a tooth whitening composition comprising hydrated calcium silicate and a tooth whitening active material.
본 명세서에서 사용되는 용어, "수화된 칼슘 실리케이트"는 칼슘 실리케이트가 물과 결합하여 생긴 함수화물을 의미할 수 있다.As used herein, the term "hydrated calcium silicate" may refer to a water-containing product formed by combining calcium silicate with water.
바람직하게, 수화된 칼슘 실리케이트는 수화된 백색 포틀랜드 시멘트일 수 있다. Preferably, the hydrated calcium silicate may be hydrated white Portland cement.
보다 구체적으로, 백색 포틀랜드 시멘트가 수화되면 수산화칼슘이 생성되고, 생성된 수산화칼슘이 물과 반응하면 칼슘이온과 수산화이온이 형성될 수 있다. 이러한 반응물에 의해 pH가 중성에 머무를 수 있어, 치아 미백제의 부작용인 지각과민증이 예방되고, 칼슘으로 인한 재광화 효과가 나타날 수 있다. More specifically, when white Portland cement is hydrated, calcium hydroxide is produced, and when the produced calcium hydroxide reacts with water, calcium ions and hydroxide ions can be formed. By these reactants, the pH can remain neutral, so hypersensitivity, which is a side effect of the tooth whitening agent, can be prevented, and the remineralization effect due to calcium can appear.
즉, 수화된 칼슘 실리케이트는, 치아 미백 활성 물질 단독으로 이용했을 때 나타나는 치아의 표백 반응에 따른 치아 표면 미세 경도 저하를 예방할 수 있다. That is, the hydrated calcium silicate can prevent a decrease in the microhardness of the tooth surface due to the bleaching reaction of the tooth that occurs when the tooth whitening active material is used alone.
보다 구체적으로, 본 발명의 일 실시예에 따른 치아 미백용 조성물이 처리된 법랑질의 표면 미세 경도 (micro hardness) 는, 치아 미백용 조성물이 처리되지 않은 치아의 표면 미세 경도의 1.1 배 내지 1.5 배일 수 있다. More specifically, the microhardness of the surface of the enamel treated with the composition for teeth whitening according to an embodiment of the present invention may be 1.1 times to 1.5 times that of the surface microhardness of teeth not treated with the composition for teeth whitening. have.
특히, 본 발명의 일 실시예에 따른 치아 미백용 조성물은, pH 수준이 6.5 내지 7.5일 수 있다. 즉, 상기 치아 미백용 조성물은 중성에 가까워 치아 미백시 치아의 pH 저감에 따른 표면 미세 경도 저하를 예방할 수 있다. In particular, the composition for whitening teeth according to an embodiment of the present invention may have a pH level of 6.5 to 7.5. That is, the composition for whitening teeth is close to neutral, so that it is possible to prevent a decrease in surface microhardness due to a decrease in pH of teeth during teeth whitening.
또한, 본 발명의 일 실시예에 따른 치아 미백용 조성물의 밝기는, 치아 미백 활성 물질만을 함유하는 치아 미백용 조성물이 처리된 치아의 밝기의 1.1 배 내지 1.5 배일 수 있다. In addition, the brightness of the tooth whitening composition according to an embodiment of the present invention may be 1.1 times to 1.5 times the brightness of teeth treated with the tooth whitening composition containing only the tooth whitening active material.
즉, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 표면 미세 경도 저하를 예방할 뿐만 아니라, 국제 표준에서 요구하는 정도를 만족할 수 있다.That is, the composition for whitening teeth according to various embodiments of the present invention may not only prevent a decrease in surface micro hardness, but also satisfy the degree required by international standards.
이러한 특징에 의해, 본 발명의 일 실시예에 따른 치아 미백용 조성물은, 치아 미백 기능성 치약, 치아 미백 기능성 구강 세정제, 치아 미백 기능성 식품 등으로 제공될 수 있다. Due to these characteristics, the tooth whitening composition according to an embodiment of the present invention may be provided as a tooth whitening functional toothpaste, a teeth whitening functional mouthwash, a teeth whitening functional food, and the like.
본 발명의 특징에 따르면, 수화된 칼슘 실리케이트는, 칼슘 및 규소와 함께, 철, 알루미늄, 마그네슘 및 황 중 적어도 하나의 원소를 더욱 포함할 수 있다.According to a feature of the present invention, the hydrated calcium silicate may further include at least one element of iron, aluminum, magnesium and sulfur, along with calcium and silicon.
상기 원소들은, 수화된 칼슘 실리케이트의 활성과 연관이 있을 수 있다.These elements may be associated with the activity of hydrated calcium silicate.
바람직하게, 수화된 칼슘 실리케이트는, 칼슘 및 규소와 함께, 철, 알루미늄, 마그네슘 및 황을 모두 포함할 수 있다. 이때, 칼슘의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 65 내지 75 wt%일 수 있고, 규소의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 13 내지 19 wt%일 수 있다. 또한, 철의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 3 내지 7 wt%일 수 있고, 알루미늄의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%일 수 있고, 마그네슘의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%일 수 있다. 나아가, 황의 함량은, 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%일 수 있다. Preferably, the hydrated calcium silicate may include both iron, aluminum, magnesium and sulfur, along with calcium and silicon. In this case, the calcium content may be 65 to 75 wt% based on the total weight of the hydrated calcium silicate, and the silicon content may be 13 to 19 wt% based on the total weight of the hydrated calcium silicate. In addition, the content of iron may be 3 to 7 wt% based on the total weight of the hydrated calcium silicate, the content of aluminum may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate, and magnesium The content may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate. Furthermore, the content of sulfur may be 2 to 5 wt% based on the total weight of the hydrated calcium silicate.
그러나, 이들의 함량 및 구성은 이에 제한되는 것이 아니며, 미백 효과를 제공하면서 법랑질 표면의 미세 경도를 증진시키고, 치아 탈회를 차단하는 효과를 제공하는 한 보다 다양하게 설정될 수 있다.However, their content and composition are not limited thereto, and may be set more variously as long as they provide a whitening effect while enhancing the microhardness of the enamel surface and providing an effect of blocking tooth demineralization.
본 발명의 다른 특징에 따르면, 수화된 칼슘 실리케이트의 입자의 직경은, 2 내지 3 ㎛일 수 있다. 그러나, 이에 제한되는 것은 아니다. According to another feature of the present invention, the particle diameter of the hydrated calcium silicate may be 2 to 3 μm. However, the present invention is not limited thereto.
본 발명의 또 다른 특징에 따르면, 치아 미백용 조성물에서, 수화된 칼슘 실리케이트의 함량은 치아 미백용 조성물의 전체 중량에 대하여 0.001 내지 5 wt%일 수 있다.According to another feature of the present invention, in the composition for whitening teeth, the content of hydrated calcium silicate may be 0.001 to 5 wt% based on the total weight of the composition for whitening teeth.
바람직하게, 치아 미백용 조성물에서, 수화된 칼슘 실리케이트의 함량은 치아 미백용 조성물의 전체 중량에 대하여 0.25 내지 2 wt%일 수 있다. 보다 바람직하게, 치아 미백용 조성물에서, 수화된 칼슘 실리케이트의 함량은 치아 미백용 조성물의 전체 중량에 대하여 0.5 내지 1.5 wt%일 수 있다. 보다 더 바람직하게, 치아 미백용 조성물에서, 수화된 칼슘 실리케이트의 함량은 치아 미백용 조성물의 전체 중량에 대하여 0.7 내지 1.25 wt%일 수 있으나, 이에 제한되는 것은 아니다.Preferably, in the composition for whitening teeth, the content of hydrated calcium silicate may be 0.25 to 2 wt% based on the total weight of the composition for whitening teeth. More preferably, in the composition for whitening teeth, the content of hydrated calcium silicate may be 0.5 to 1.5 wt% based on the total weight of the composition for whitening teeth. Even more preferably, in the tooth whitening composition, the content of hydrated calcium silicate may be 0.7 to 1.25 wt% based on the total weight of the tooth whitening composition, but is not limited thereto.
본 명세서에서 사용되는 용어, "치아 미백 활성 물질"은, 치아 표면 혹은 내면에서 분해되어 산소를 발생시키고, 착색된 물질을 표백하여 치아 미백 효과를 제공하는 물질을 의미할 수 있다. As used herein, the term "tooth whitening active material" may refer to a material that decomposes on the surface or inner surface of a tooth to generate oxygen, and bleaches a colored material to provide a tooth whitening effect.
본 발명의 또 다른 특징에 따르면, 치아 미백 활성 물질은, 과산화수소, 과산화칼슘, 카바마이드 퍼옥사이드 (carbamide peroxide), 퍼옥시산, 과산화탄산염, 과산화황산염, 과산화우레아, 과산화붕산염, 금속 아염소산염, 과산화피로인산나트륨 및 과산화탄산나트륨 중 적어도 하나일 수 있다.According to another feature of the present invention, the tooth whitening active material is hydrogen peroxide, calcium peroxide, carbamide peroxide, peroxy acid, peroxycarbonate, peroxysulfate, urea peroxide, peroxyborate, metal chlorite, peroxide It may be at least one of sodium pyrophosphate and sodium peroxide.
바람직하게, 치아 미백 활성 물질은 과산화수소일 수 있고, 보다 바람직하게, 치아 미백 활성 물질은 35 % 과산화수소일 수 있다. 그러나, 이에 제한되는 것은 아니다.Preferably, the tooth whitening active material may be hydrogen peroxide, more preferably, the tooth whitening active material may be 35% hydrogen peroxide. However, the present invention is not limited thereto.
본 발명의 또 다른 특징에 따르면, 치아 미백용 조성물에서, 치아 미백 활성 물질의 함량은 치아 미백용 조성물의 전체 중량에 대하여 95 내지 99.999 wt%일 수 있다. 바람직하게, 치아 미백용 조성물에서, 치아 미백 활성 물질의 함량은 치아 미백용 조성물의 전체 중량에 대하여 98 내지 99.75 wt%일 수 있다. 보다 바람직하게, 치아 미백용 조성물에서, 치아 미백 활성 물질의 함량은 치아 미백용 조성물의 전체 중량에 대하여 98.5 내지 99.5 wt%일 수 있다. 보다 더 바람직하게, 치아 미백용 조성물에서, 치아 미백 활성 물질의 함량은 치아 미백용 조성물의 전체 중량에 대하여 98.75 내지 99.3 wt%일 수 있으나, 이에 제한되는 것은 아니다.According to another feature of the present invention, in the tooth whitening composition, the content of the tooth whitening active material may be 95 to 99.999 wt% based on the total weight of the tooth whitening composition. Preferably, in the tooth whitening composition, the content of the tooth whitening active material may be 98 to 99.75 wt% based on the total weight of the tooth whitening composition. More preferably, in the tooth whitening composition, the content of the tooth whitening active material may be 98.5 to 99.5 wt% based on the total weight of the tooth whitening composition. Even more preferably, in the tooth whitening composition, the content of the tooth whitening active material may be 98.75 to 99.3 wt% based on the total weight of the tooth whitening composition, but is not limited thereto.
본 발명의 다른 실시예에 따르면, 수화된 칼슘 실리케이트를 준비하는 단계, 및 치아 미백용 조성물을 획득하도록, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질을 혼합하는 단계를 포함하는 치아 미백용 조성물의 제조 방법이 제공된다.According to another embodiment of the present invention, a method for preparing a composition for teeth whitening, comprising the steps of preparing hydrated calcium silicate, and mixing the hydrated calcium silicate and a tooth whitening active material to obtain a composition for teeth whitening. this is provided
이때, 수화된 칼슘 실리케이트는, 철, 알류미늄, 마그네슘 및 황 중 적어도 하나를 더 포함할 수 있다.In this case, the hydrated calcium silicate may further include at least one of iron, aluminum, magnesium, and sulfur.
본 발명의 특징에 따르면, 수화된 칼슘 실리케이트를 준비하는 단계에서, 혼합물을 획득하도록, 칼슘 실리케이트 및 물을 혼합하고, 고형 혼합물을 획득하도록, 혼합물을 경화하고, 수화된 칼슘 실리케이트 파우더를 획득하도록, 고형 혼합물을 분쇄하는 단계가 수행될 수 있다. According to a feature of the present invention, in the step of preparing hydrated calcium silicate, to obtain a mixture, to mix calcium silicate and water, to obtain a solid mixture, to harden the mixture, to obtain a hydrated calcium silicate powder; A step of grinding the solid mixture may be performed.
본 발명의 다른 특징에 따르면, 혼합하는 단계에서, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질을 0.0001:99.9999 내지 5:95의 중량비로 혼합하는 단계가 수행될 수 있다.According to another feature of the present invention, in the mixing step, a step of mixing the hydrated calcium silicate and the tooth whitening active material in a weight ratio of 0.0001:99.9999 to 5:95 may be performed.
본 발명의 또 다른 실시예에 따르면, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 유효 성분으로 하는 치아 미백 기능성 식품이 제공된다.According to another embodiment of the present invention, there is provided a tooth whitening functional food comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
이때, 치아 미백 기능성 식품은 껌, 사탕, 엿, 젤리 및 카라멜 중 적어도 하나의 형태로 제공될 수 있다. In this case, the tooth whitening functional food may be provided in the form of at least one of gum, candy, candy, jelly, and caramel.
본 발명의 또 다른 실시예에 따르면, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 유효 성분으로 하는 치아 미백 기능성 치약이 제공된다.According to another embodiment of the present invention, there is provided a tooth whitening functional toothpaste comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
본 발명의 또 다른 실시예에 따르면, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 유효 성분으로 하는 치아 미백 기능성 구강 세정제가 제공된다.According to another embodiment of the present invention, there is provided a tooth whitening functional mouthwash comprising the tooth whitening composition according to various embodiments of the present invention as an active ingredient.
이하, 실시예를 통하여 본 발명을 보다 상세히 설명한다. 다만, 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것에 불과하므로 본 발명의 범위가 이들 실시예에 의해 한정되는 것으로 해석되어서는 아니된다.Hereinafter, the present invention will be described in more detail through examples. However, since these examples are only for illustrative purposes of the present invention, the scope of the present invention should not be construed as being limited by these examples.
본 발명은, 칼슘 실리케이트 및 치아 미백 활성 물질을 포함하는 치아 미백용 조성물을 제공함으로써, 종래의 과산화수소와 같은 치아 미백 활성 물질 단독으로 구성된 치아 미백용 조성물이 갖는 한계점을 극복할 수 있다.The present invention provides a tooth whitening composition comprising calcium silicate and a tooth whitening active material, thereby overcoming the limitations of the conventional tooth whitening composition comprising only a tooth whitening active material such as hydrogen peroxide.
보다 구체적으로, 본 발명은, 치아의 표백 반응에 따른 낮은 pH 환경을 막지 못해 치아 표백 과정에 따른 치아 경도 저하가 일어나는 종래의 치아 미백용 조성물의 한계를 극복할 수 있다.More specifically, the present invention can overcome the limitations of the conventional composition for whitening teeth in which tooth hardness decreases due to the tooth bleaching process by failing to prevent the low pH environment caused by the bleaching reaction of teeth.
특히, 본 발명은 수화된 칼슘 실리케이트를 치아 미백 활성 물질과 함께 제공함에 따라, 미백 효과를 제공하면서 치아 미백 활성 물질을 단독으로 이용했을 때 보다 우수한 법랑질 표면의 미세 경도를 제공하고, 치아 탈회를 차단할 수 있다.In particular, as the present invention provides hydrated calcium silicate together with a tooth whitening active material, it provides a whitening effect while providing a fine hardness of the enamel surface that is superior to that when the tooth whitening active material is used alone, and prevents tooth demineralization. can
나아가, 본 발명은, 국제 표준 기구에서 규정한 치아 미백제의 필요 조건인, 치아 미백용 조성물 처치 후 비커스 표면 경도 감소가 10 미만인 조건을 만족할 수 있다. Furthermore, the present invention may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization.
본 발명은, 치아 미백용 조성물로서의 효력이 유지되면서 법랑질 표면 미세 경도 손실 예방 및 치아 탈회 차단 효과가 증가된, 치아 미백용 조성물 내의 각 조성들의 유효 함량을 제공할 수 있다. The present invention can provide an effective amount of each composition in the composition for whitening teeth, while maintaining the effectiveness as a composition for whitening teeth, preventing loss of fine enamel surface hardness and blocking tooth demineralization.
이에, 본 발명은, 상기와 같은 활성에 따라, 치아 미백 기능성 식품 조성물, 치약 및 구강 세정제 등으로 제공될 수 있다. Accordingly, the present invention may be provided as a tooth whitening functional food composition, toothpaste, mouthwash, and the like according to the above-described activity.
본 발명에 따른 효과는 이상에서 예시된 내용에 의해 제한되지 않으며, 더욱 다양한 효과들이 본 명세서 내에 포함되어 있다.The effect according to the present invention is not limited by the contents exemplified above, and more various effects are included in the present specification.
도 1은 본 발명의 일 실시예에 따른 치아 미백용 조성물의 제조 방법을 예시적으로 도시한 것이다. 1 exemplarily shows a method for preparing a tooth whitening composition according to an embodiment of the present invention.
도 2a 및 2b는 본 발명의 다양한 실시예에 이용되는 수화된 칼슘 실리케이트의 원소 분석 결과를 도시한 것이다.2A and 2B show the results of elemental analysis of hydrated calcium silicate used in various examples of the present invention.
도 2c는 본 발명의 다양한 실시예에 이용되는 수화된 칼슘 실리케이트의 입자 형태를 도시한 것이다.2C shows the particle morphology of hydrated calcium silicate used in various embodiments of the present invention.
도 3은 본 발명의 일 실시예에 따른 치아 미백용 조성물의 조성 및 함량을 도시한 결과이다.3 is a result showing the composition and content of the tooth whitening composition according to an embodiment of the present invention.
도 4는 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 pH 수준을 나타내는 결과이다.4 is a result showing the pH level according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
도 5a 내지 5c는 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 치아 밝기 변화를 나타내는 결과이다.5A to 5C are results showing changes in tooth brightness according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
도 6a 및 6b는 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 치아 표면 미세 경도 수준을 나타내는 결과이다.6a and 6b are results showing the tooth surface microhardness level according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
도 7은 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 법랑질 표면 변화를 나타내는 결과이다.7 is a result showing the change of the enamel surface according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
본 발명의 이점 및 특징, 그리고 그것들을 달성하는 방법은 첨부되는 도면과 함께 상세하게 후술되어 있는 실시예들을 참조하면 명확해질 것이다. 그러나, 본 발명은 이하에서 개시되는 실시예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 것이며, 단지 본 실시예들은 본 발명의 개시가 완전하도록 하며, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다. Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be embodied in various different forms, and only these embodiments allow the disclosure of the present invention to be complete, and common knowledge in the art to which the present invention pertains It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims.
이하에서는 도 1을 참조하여, 본 발명의 다양한 실시예에 이용되는 치아 미백용 조성물의 제조 방법을 설명한다.Hereinafter, a method for preparing a tooth whitening composition used in various embodiments of the present invention will be described with reference to FIG. 1 .
도 1은 본 발명의 일 실시예에 따른 치아 미백용 조성물의 제조 방법을 예시적으로 도시한 것이다.1 exemplarily shows a method for preparing a tooth whitening composition according to an embodiment of the present invention.
도 1을 참조하면, 본 발명의 치아 미백용 조성물은 수화된 칼슘 실리케이트가 준비되고 (S110), 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되어 (S120) 제조될 수 있다.Referring to FIG. 1 , the tooth whitening composition of the present invention may be prepared by preparing hydrated calcium silicate (S110), and mixing hydrated calcium silicate and a tooth whitening active material (S120).
본 발명의 특징에 따르면, 수화된 칼슘 실리케이트가 준비되는 단계 (S110) 에서, 수화된 칼슘 실리케이트로서 수화된 백색 포틀랜드 시멘트가 이용될 수 있다. 이때, 수화된 칼슘 실리케이트는, 구성 원소로서 철, 알루미늄, 마그네슘 및 황 중 적어도 하나를 더 포함할 수 있다. According to a feature of the present invention, in the step S110 in which the hydrated calcium silicate is prepared, hydrated white Portland cement may be used as the hydrated calcium silicate. In this case, the hydrated calcium silicate may further include at least one of iron, aluminum, magnesium and sulfur as a constituent element.
본 발명의 다른 특징에 따르면, 수화된 칼슘 실리케이트가 준비되는 단계 (S110) 에서, 칼슘 실리케이트 및 물이 혼합된 후 경화되고, 고형 혼합물이 분쇄되어 수화된 칼슘 실리케이트 파우더가 획득될 수 있다.According to another feature of the present invention, in the step of preparing the hydrated calcium silicate (S110), the calcium silicate and water are mixed and then cured, and the solid mixture is pulverized to obtain a hydrated calcium silicate powder.
예를 들어, 수화된 칼슘 실리케이트가 준비되는 단계 (S110) 에서, 백색 포틀랜드 시멘트는 증류수와 0.33 (water/powder) 비율로 1분 간 유리판에서 플라스틱 스파튤라를 이용하여 핸드 믹싱 (hand mixing) 될 수 있다. 그 다음, 혼합물은 37±1 ℃상대습도 100 %에서 3일 동안 경화될 수 있다. 경화된 고형 혼합물은, 볼밀 (ball mill) 로 450 rpm에서 40분간 분쇄된 후, 400-메쉬 체 진동기 (400-mesh sieve shaker) 로 필터링될 수 있다. 수화된 칼슘 실리케이트가 준비되는 단계 (S110) 의 결과로, 평균 입자 크기가 2.465 μm인 수화된 칼슘 실리케이트 파우더가 준비될 수 있다. 그러나, 수화된 칼슘 실리케이트의 획득 방법은 전술한 것에 제한되는 것은 아니다. For example, in the step of preparing hydrated calcium silicate (S110), white Portland cement is hand mixed with distilled water at a ratio of 0.33 (water/powder) for 1 minute on a glass plate using a plastic spatula. have. Then, the mixture can be cured for 3 days at 37±1°C and 100% relative humidity. The cured solid mixture may be milled at 450 rpm for 40 minutes with a ball mill, and then filtered with a 400-mesh sieve shaker. As a result of the step (S110) in which the hydrated calcium silicate is prepared, a hydrated calcium silicate powder having an average particle size of 2.465 μm can be prepared. However, the method for obtaining the hydrated calcium silicate is not limited to the above.
다음으로, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되는 단계 (S120) 에서, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되어 치아 미백용 조성물이 획득될 수 있다.Next, in the step of mixing the hydrated calcium silicate and the tooth whitening active material ( S120 ), the hydrated calcium silicate and the tooth whitening active material are mixed to obtain a tooth whitening composition.
이때, 치아 미백 활성 물질은, 과산화수소일 수 있다. 보다 바람직하게, 치아 미백 활성 물질은 35 % 과산화수소일 수 있으나, 이에 제한되는 것은 아니며 In this case, the tooth whitening active material may be hydrogen peroxide. More preferably, the tooth whitening active material may be, but is not limited to, 35% hydrogen peroxide.
본 발명의 특징에 따르면, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되는 단계 (S120) 에서, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질은 0.0001:99.9999 내지 5:95의 중량비로 혼합될 수 있다.According to a feature of the present invention, in the step of mixing the hydrated calcium silicate and the tooth whitening active material (S120), the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.0001:99.9999 to 5:95.
바람직하게, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되는 단계 (S120) 에서, 수화된 칼슘 실리케이트 및 상기 치아 미백 활성 물질은 0.25:99.75 내지 2:98의 중량비로 혼합될 수 있다. Preferably, in the step S120 of mixing the hydrated calcium silicate and the tooth whitening active material, the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.25:99.75 to 2:98.
보다 바람직하게, 수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되는 단계 (S120) 에서, 수화된 칼슘 실리케이트 및 상기 치아 미백 활성 물질은 0.5:99.5 내지 1.5:98.5의 중량비로 혼합될 수 있다.More preferably, in the step of mixing the hydrated calcium silicate and the tooth whitening active material (S120), the hydrated calcium silicate and the tooth whitening active material may be mixed in a weight ratio of 0.5:99.5 to 1.5:98.5.
수화된 칼슘 실리케이트 및 치아 미백 활성 물질이 혼합되는 단계 (S120) 에 의해 획득된 수화된 칼슘 실리케이트가 첨가된 치아 미백용 조성물은, 미백 효과를 제공하면서 치아 미백 활성 물질을 단독으로 이용했을 때 보다 법랑질 표면의 미세 경도가 우수하고, 치아 탈회를 차단할 수 있다.The composition for whitening teeth to which hydrated calcium silicate is added, obtained by the step (S120) of mixing the hydrated calcium silicate and the tooth whitening active material, provides a whitening effect, while providing a whitening effect with more enamel than when the tooth whitening active material is used alone. It has excellent surface hardness and can block tooth demineralization.
특히, 수화된 칼슘 실리케이트가 첨가된 치아 미백용 조성물은, 국제 표준 기구에서 규정한 치아 미백제의 필요 조건인, 치아 미백용 조성물 처치 후 비커스 표면 경도 감소가 10 미만인 조건을 만족할 수 있다. In particular, the composition for whitening teeth to which hydrated calcium silicate is added may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent prescribed by the International Standards Organization.
평가 1: 본 발명의 다양한 실시예에 이용되는 수화된 칼슘 실리케이트의 특성Evaluation 1: Properties of Hydrated Calcium Silicate Used in Various Examples of the Invention
도 2a 및 2b는 본 발명의 다양한 실시예에 이용되는 수화된 칼슘 실리케이트의 원소 분석 결과를 도시한 것이다. 도 2c는 본 발명의 다양한 실시예에 이용되는 수화된 칼슘 실리케이트의 입자 형태를 도시한 것이다.2A and 2B show the results of elemental analysis of hydrated calcium silicate used in various examples of the present invention. Figure 2c shows the particle morphology of hydrated calcium silicate used in various embodiments of the present invention.
도 2a 및 2b를 함께 참조하면, 먼저, 본 평가에서는 수화된 칼슘 실리케이트 파우더의 구성 원소를 분석하기 위해, EDS (Energy Dispersive X-ray Spectrometer) 를 시행한 결과가 나타난다. 보다 구체적으로, 수화된 칼슘 실리케이트 파우더는 칼슘 (Ca), 규소 (Si), 철 (F), 알루미늄 (Al), 마그네슘 (Mg) 및 황 (S) 으로 이루어져 있으며, 칼슘이 70.70 wt%로 가장 많이 함유되어 있는 것으로 나타난다. 그 다음, 규소가 16.05 wt%, 철이 5.53 wt%, 알루미늄이 3.53 wt%, 마그네슘이 2.16 wt%, 황이 2.04 wt%로 함유된 것으로 나타난다. Referring to FIGS. 2A and 2B together, first, in this evaluation, in order to analyze the constituent elements of the hydrated calcium silicate powder, the results of EDS (Energy Dispersive X-ray Spectrometer) are shown. More specifically, the hydrated calcium silicate powder consists of calcium (Ca), silicon (Si), iron (F), aluminum (Al), magnesium (Mg) and sulfur (S), with calcium being the most It appears to contain a lot. Then, 16.05 wt% of silicon, 5.53 wt% of iron, 3.53 wt% of aluminum, 2.16 wt% of magnesium, and 2.04 wt% of sulfur are shown.
한편, 미백 효과를 제공하면서 법랑질 표면의 미세 경도를 증진시키고, 치아 탈회를 차단하는 효과는, 전술한 함량 및 구성에서 제한되는 것이 아니다. 예를 들어, 수화된 칼슘 실리케이트는, 수화된 칼슘 실리케이트의 전체 중량에 대하여 65 내지 75 wt%의 칼슘, 수화된 칼슘 실리케이트의 전체 중량에 대하여 13 내지 19 wt%의 규소에, 철, 알루미늄, 마그네슘 및 황 중 적어도 하나의 원소를 더욱 포함할 수 있다. 이상의 구성 요소를 포함하는 수화된 칼슘 실리케이트는, 미백 효과와 함께 법랑질 표면의 미세 경도를 증진시키고, 치아 탈회를 차단하는 효과를 제공할 수 있다. On the other hand, the effect of enhancing the microhardness of the enamel surface while providing a whitening effect and blocking tooth demineralization is not limited by the above-described content and composition. For example, hydrated calcium silicate may be present in an amount of 65 to 75 wt % calcium based on the total weight of the hydrated calcium silicate, 13 to 19 wt % of silicon with respect to the total weight of the hydrated calcium silicate, iron, aluminum, magnesium and at least one element of sulfur. The hydrated calcium silicate containing the above components may provide an effect of improving the microhardness of the enamel surface along with a whitening effect and blocking tooth demineralization.
도 2c를 참조하면, 수화된 칼슘 실리케이트 입자에 대한 2,000 배율에서의 SEM (Scanning Electron Microscope) 이미지가 도시된다. 이때, 수화된 칼슘 실리케이트 입자의 크기는 약 2.465 μm일 수 있다. Referring to FIG. 2C , a Scanning Electron Microscope (SEM) image at 2,000 magnification of hydrated calcium silicate particles is shown. At this time, the size of the hydrated calcium silicate particles may be about 2.465 μm.
이와 같은 구조적 특성을 갖는 수화된 칼슘 실리케이트는, 물과 반응했을 때, 칼슘이온과 수산화이온을 형성할 수 있다. 이러한 반응물에 의해 pH가 중성에 머무를 수 있어, 치아 미백제의 부작용인 지각과민증이 보완되고, 칼슘으로 인한 재광화 효과가 나타날 수 있다. 따라서, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물의 구성 요소로서 제공될 수 있다.Hydrated calcium silicate having such structural properties may form calcium ions and hydroxide ions when reacted with water. By these reactants, the pH can remain neutral, so hypersensitivity, which is a side effect of the tooth whitening agent, can be supplemented, and the remineralization effect due to calcium can appear. Accordingly, it may be provided as a component of the tooth whitening composition according to various embodiments of the present invention.
이하에서는 평가 2 내지 평가 5를 참조하여, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물의 특징 및 효과에 대하여 설명한다. 이때, 수화된 칼슘 실리케이트로서 수화된 백색 포틀랜드 시멘트의 파우더가 이용되었고, 치아 미백 활성 물질로서 35 % 과산화수소가 이용되었으나, 본 발명의 효과는 전술한 구성 요소에 제한되는 것은 아니다. 예를 들어, 치아 미백 활성 물질은, 과산화칼슘, 카바마이드 퍼옥사이드 (carbamide peroxide), 퍼옥시산, 과산화탄산염, 과산화황산염, 과산화우레아, 과산화붕산염, 금속 아염소산염, 과산화피로인산나트륨 및 과산화탄산나트륨 중 적어도 하나일 수 있으며, 수화된 칼슘 실리케이트 및 과산화수소를 치아 미백 활성 물질로 사용한 것과 유사한 수준의 활성도를 가질 수 있다.Hereinafter, with reference to Evaluation 2 to Evaluation 5, characteristics and effects of the tooth whitening composition according to various embodiments of the present invention will be described. At this time, powder of hydrated white Portland cement was used as the hydrated calcium silicate and 35% hydrogen peroxide was used as the tooth whitening active material, but the effect of the present invention is not limited to the above-described components. For example, the tooth whitening active substance is selected from among calcium peroxide, carbamide peroxide, peroxyacid, peroxycarbonate, peroxysulfate, urea peroxide, peroxyborate, metal chlorite, sodium peroxypyrophosphate and sodium peroxide. It may be at least one, and may have a level of activity similar to that of using hydrated calcium silicate and hydrogen peroxide as the tooth whitening active material.
한편, 도 3을 참조하면, 본 평가를 위해 전체 조성물의 중량에 대하여 35% 과산화수소 100 wt%로 구성된 대조군이 설정되었다. 나아가, 과산화수소 99.75 wt% 및 수화된 칼슘 실리케이트 (hydrated calcium silicate, hCS) 0.25 wt%로 구성된 hCS0.25, 과산화수소 99.50 wt% 및 수화된 칼슘 실리케이트 0.50 wt%로 구성된 hCS0.50, 과산화수소 99.00 wt% 및 수화된 칼슘 실리케이트 1.00 wt%로 구성된 hCS1.00, 및 과산화수소 98.00 wt% 및 수화된 칼슘 실리케이트 2.00 wt%로 구성된 hCS2.00의 실험군이 설정되었다. On the other hand, referring to FIG. 3 , a control consisting of 35% hydrogen peroxide and 100 wt% based on the weight of the total composition was set for this evaluation. Furthermore, hCS0.25 composed of 99.75 wt% of hydrogen peroxide and 0.25 wt% of hydrated calcium silicate (hCS), hCS0.50 composed of 99.50 wt% of hydrogen peroxide and 0.50 wt% of hydrated calcium silicate, 99.00 wt% of hydrogen peroxide and Experimental groups were established of hCS1.00 consisting of 1.00 wt % of hydrated calcium silicate, and hCS2.00 consisting of 98.00 wt % of hydrogen peroxide and 2.00 wt % of hydrated calcium silicate.
평가 2: 본 발명의 다양한 실시예에 따른 치아 미백용 조성물의 pH 수준Evaluation 2: pH level of the tooth whitening composition according to various embodiments of the present invention
본 평가에서, hCS0.25, hCS0.50, hCS1.00 및 hCS2.00의 각각의 실험군은 10초 동안 볼텍싱 (vortexing) 되어 균일화되었고, 각 용액의 pH를 분석하기 위해 실험군의 혼합물들은 측정 직전 10초 동안 혼합된 후 pH 미터기를 이용하여 즉시 pH 값이 측정되었다. 이때, pH 측정은 15 분 동안 1분 간격으로 진행되었다.In this evaluation, each experimental group of hCS0.25, hCS0.50, hCS1.00 and hCS2.00 was vortexed for 10 seconds to homogenize, and in order to analyze the pH of each solution, the mixtures of the experimental group were mixed immediately before measurement. After mixing for 10 seconds, the pH value was measured immediately using a pH meter. At this time, the pH measurement was performed at 1 minute intervals for 15 minutes.
도 4는 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 pH 수준을 나타내는 결과이다.4 is a result showing the pH level according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
도 4를 참조하면, 과산화수소로만 이루어진 대조군은 pH 값이 2.24 ± 0.03로 시작하여 15분 후 2.17 ± 0.10으로, 다른 실험군들에 비해 낮은 pH 값을 갖는 것으로 나타난다. 이와 대조적으로, 수화된 칼슘 실리케이트를 함유하는 hCS0.25는 제조 10초 후 pH 값이 6.84 ± 0.02로, 15분 후 pH 값이 6.95 ± 0.07인 것으로 나타나고, hCS0.50는 제조 10초 후 pH 값이 7.06 ± 0.01, 15분 후 pH 값이 7.35± 0.02인 것으로 나타난다. 또한, hCS1.00는 제조 10초 후 pH 값이 7.27 ± 0.04, 15분 후 pH 값이 7.78 ± 0.03으로 나타나고, hCS2.00은 제조 10초 후 pH 값이 7.52 ± 0.05, 15분 후 pH 값이 8.05 ± 0.02로 가장 높은 것으로 나타난다. 즉, 수화된 칼슘 실리케이트를 함유한 치아 미백용 조성물의 pH는 모두 중성에 가까운 값으로 나타난다. 이때, 수화된 칼슘 실리케이트를 함유한, 중성의 치아 미백용 조성물은, 치아 미백 과정에서 수산화 이온을 형성하여 pH 저하를 막고, pH를 중성으로 유지하여 치아의 손상을 예방할 수 있다. Referring to FIG. 4 , the control group consisting only of hydrogen peroxide has a pH value of 2.24 ± 0.03 starting at 2.17 ± 0.10 after 15 minutes, which is lower than that of other experimental groups. In contrast, hCS0.25 containing hydrated calcium silicate showed a pH value of 6.84 ± 0.02 after 10 seconds of preparation, a pH value of 6.95 ± 0.07 after 15 minutes, and hCS0.50 had a pH value of 10 seconds after preparation. After this 7.06 ± 0.01, the pH value after 15 minutes appears to be 7.35 ± 0.02. In addition, hCS1.00 has a pH value of 7.27 ± 0.04 after 10 seconds of manufacture and 7.78 ± 0.03 after 15 minutes, and hCS2.00 has a pH value of 7.52 ± 0.05 after 10 seconds of manufacture and a pH value of 15 minutes after 8.05 ± 0.02, which is the highest. That is, the pH of the tooth whitening composition containing the hydrated calcium silicate appears as a value close to neutral. In this case, the neutral tooth whitening composition containing hydrated calcium silicate forms hydroxide ions in the tooth whitening process to prevent a decrease in pH, and maintains the pH neutral to prevent damage to teeth.
이상의 평가 2의 결과에 따르면, 수화된 칼슘 실리케이트를 함유한 본 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 대조군의 과산화수소만을 함유한 조성물과 대조적으로 pH를 중성으로 유지하는 것으로 나타난다. 이에, 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 치아 미백제의 부작용인 지각과민증을 예방할뿐만 아니라, 칼슘으로 인한 재광화 효과를 제공할 수 있다. According to the result of evaluation 2 above, it appears that the composition for whitening teeth according to various embodiments of the present invention containing hydrated calcium silicate maintains a neutral pH, in contrast to the control composition containing only hydrogen peroxide. Accordingly, the composition for whitening teeth according to various embodiments of the present invention can prevent hypersensitivity, which is a side effect of the tooth whitening agent, as well as provide a remineralization effect due to calcium.
평가 3: 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리한 치아의 미백 효과 Evaluation 3: Teeth whitening effect treated with the tooth whitening composition according to various embodiments of the present invention
본 평가에서는, 치아 미백용 조성물의 미백 효과를 평가하기 위해, 시편이 이용되었다. 이때, 시편 제작을 위해, 치근이 분리된 우치의 치관 순면이 바닥으로 향하도록 지름 3 cm인 원형 몰드에 위치되었고, 폴리에스터 레진 (Polycoat) 이 주입된 후, 24 시간 동안 상대습도 30±5%, 25±2℃ 조건에서 경화되었다. 그 다음, 경화된 시편은, 자동 연마기를 이용하여 P800, P100, P1200의 단계적 연마가 진행되어 우치의 법랑질 표면이 균일화 되었다. 이의 결과로 균일화된 시편이 획득되었다. In this evaluation, in order to evaluate the whitening effect of the tooth whitening composition, a specimen was used. At this time, for specimen preparation, it was placed in a circular mold with a diameter of 3 cm so that the crown surface of the right tooth from which the tooth root was separated faces toward the floor, and after the polyester resin (Polycoat) was injected, the relative humidity was 30±5% for 24 hours. , was cured at 25±2℃ conditions. Then, the hardened specimen was polished in stages of P800, P100, and P1200 using an automatic grinder to uniformize the enamel surface of the tooth. As a result of this, a homogenized specimen was obtained.
그 다음, 시편은 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 적용하기 전, 일정한 색을 만들어주는 과정을 진행하기 위해 착색 용액 (staining solution) 에 침지되었고, 37±1℃의 상대습도 100 % 에서 3일 동안 보관되었다. 이때, 착색 용액은 24시간 마다 새로운 용액으로 바꿔주었다. 3일 후 시편은 증류수를 이용하여 씻겨진 후 건조되었다.Then, the specimen was immersed in a staining solution in order to proceed with a process of making a certain color before applying the tooth whitening composition according to various embodiments of the present invention, and a relative humidity of 100 at 37±1° C. % was stored for 3 days. At this time, the coloring solution was changed to a new solution every 24 hours. After 3 days, the specimens were washed with distilled water and dried.
그 다음, hCS0.25, hCS0.50, hCS1.00, hCS2.00의 치아 미백용 조성물이 미백 처리 직전 제조되어 10 초간 혼합된 후 100 μl씩 시편에 처리되었다. 이후, 시편은 37±1℃의 상대습도 100 % 에서 15분 동안 보관되었고, 증류수를 이용하여 씻겨진 후 건조되었다. 본 과정을 총 3번 반복하여 총 45분 동안 시편은 치아 미백용 조성물에 노출되었다. Then, a tooth whitening composition of hCS0.25, hCS0.50, hCS1.00, and hCS2.00 was prepared immediately before the whitening treatment, mixed for 10 seconds, and then treated with 100 μl of each specimen. Thereafter, the specimen was stored for 15 minutes at 100% relative humidity of 37±1° C., washed with distilled water, and dried. This process was repeated a total of 3 times and the specimen was exposed to the tooth whitening composition for a total of 45 minutes.
그 다음, 미백 분석을 위해, 분광광도계 (spectrophotometer) 를 이용하여 3 mm 측정 윈도우에 본 발명의 다양한 실시예에 따른 치아 미백용 조성물이 처리된 시편이 위치었고, 무작위로 시편에 대한 세 부위의 명도 (L*), 채도 (a*, b*) 가 측정되었다. 이때, 명도, 채도의 평균값이 대표값으로 설정되었다. 그 다음, 대표값에 기초하여, 미백 정도에 대응한 △E*가 하기의 수학식 1에 따라 산출되었다.Then, for the whitening analysis, the specimen treated with the tooth whitening composition according to various embodiments of the present invention was placed in a 3 mm measurement window using a spectrophotometer, and the brightness of the three parts for the specimen was randomly placed. (L*) and chroma (a*, b*) were measured. At this time, the average values of brightness and saturation were set as representative values. Then, based on the representative values, ΔE* corresponding to the degree of whitening was calculated according to the following equation (1).
[수학식 1][Equation 1]
Figure PCTKR2021009914-appb-I000001
Figure PCTKR2021009914-appb-I000001
여기서, Lbefore은, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리하기 이전의 시편의 명도이고, Lafter는 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리한 후의 시편의 명도이다. 또한, abefore 및 bbefore 은, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리하기 이전의 시편의 채도이고, aafter 및 bafter는 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리한 후의 시편의 채도이다.Here, L before is the brightness of the specimen before treatment with the composition for teeth whitening according to various embodiments of the present invention, and L after is the brightness of the specimen after treatment with the composition for teeth whitening according to various embodiments of the present invention. to be. In addition, a before and b before are the saturation of the specimen before treatment with the tooth whitening composition according to various embodiments of the present invention, a after and b after is the saturation of the specimen after treatment with the tooth whitening composition according to various embodiments of the present invention.
보다 구체적으로, △L*은 백색과 흑색의 정도를 의미할 수 있다. 또한 △a*는 적색과 녹색의 정도이고, △b*는 황색과 청색의 정도를 의미할 수 있다.More specifically, ΔL* may mean the degree of white and black. In addition, Δa* may indicate the degree of red and green, and Δb* may indicate the degree of yellow and blue.
도 5a 내지 5c는 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 치아 밝기 변화를 나타내는 결과이다.5A to 5C are results showing changes in tooth brightness according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
먼저, 도 5a 및 5c를 참조하면, hCS0.25, hCS0.50, hCS1.00, hCS2.00의 본 발명의 다양한 실시예에 따른 치아 미백용 조성물의 처리에 따라, 시편의 △L*은 증가한 것으로 나타난다. 나아가, 도 5b 및 도 5c를 참조하면, 본 발명의 다양한 실시예에 따른 치아 미백용 조성물의 처리에 따라, 시편의 △b*는 감소한 것으로 나타난다. 이는, 착색된 시편에 대한 미백 효과가 있음을 의미할 수 있다. First, referring to FIGS. 5A and 5C , according to the treatment of the tooth whitening composition according to various embodiments of the present invention of hCS0.25, hCS0.50, hCS1.00, and hCS2.00, ΔL* of the specimen increased appears to be Furthermore, referring to FIGS. 5B and 5C , according to the treatment of the tooth whitening composition according to various embodiments of the present invention, Δb* of the specimen is decreased. This may mean that there is a whitening effect on the colored specimen.
특히, 도 5c를 참조하면, △L* 및 △b*에 기초하여 산출된 △E* 값을 참조하면, hCS0.25, hCS0.50, hCS1.00의 실험군은 과산화수소로만 이루어진 대조군보다 우수한 미백 활성을 갖는 것으로 나타난다. 이때, 모든 실험군은, 치아 미백제에 대한 국제 표준인 ISO 28399에서 규정된 미백 효과 평가 기준에 대응하는 것으로 나타난다. In particular, referring to FIG. 5c , referring to the ΔE * values calculated based on ΔL* and Δb*, the experimental groups of hCS0.25, hCS0.50, and hCS1.00 showed superior whitening activity than the control group consisting of only hydrogen peroxide. appears to have At this time, all experimental groups appear to correspond to the whitening effect evaluation criteria stipulated in ISO 28399, an international standard for tooth whitening agents.
이상의 평가 3의 결과에 따르면, 수화된 칼슘 실리케이트를 함유한 본 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 대조군의 과산화수소만을 함유한 치아 미백용 조성물보다 우수한 치아 미백 효과를 제공하는 것으로 나타난다. According to the results of Evaluation 3 above, the composition for teeth whitening according to various embodiments of the present invention containing hydrated calcium silicate provides a tooth whitening effect superior to the control composition for teeth whitening containing only hydrogen peroxide.
평가 4: 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리한 치아의 표면 미세 경도 증가 효과Evaluation 4: Effect of increasing the surface microhardness of teeth treated with the tooth whitening composition according to various embodiments of the present invention
본 평가에서는, 전술한 평가 3의 방법과 동일한 방법으로 제작된 시편에 대하여 전술한 평가 3의 방법과 동일한 방법으로 hCS0.25, hCS0.50, hCS1.00, hCS2.00의 치아 미백용 조성물이 처리되었다. 그 다음, 비커스 경도 시험기 (Vickers hardness tester) 를 이용하여 15초 동안 0.49N의 하중으로 시편의 4 부위에 대한 미세 경도가 무작위로 측정되었다. 이때, 평균값이 대표값으로 설정되었다. 그 다음, 측정값에 기초하여 하기의 수학식 2에 따라 미세 경도 손실율 (Percentage of Micro hardness Loss, △PML) 이 결정되었다. In this evaluation, the tooth whitening compositions of hCS0.25, hCS0.50, hCS1.00, and hCS2.00 were prepared in the same manner as in the above evaluation 3 with respect to the specimen manufactured by the same method as the method of evaluation 3 described above. has been processed Then, using a Vickers hardness tester (Vickers hardness tester) with a load of 0.49N for 15 seconds, the microhardness was randomly measured for 4 parts of the specimen. At this time, the average value was set as the representative value. Then, based on the measured value, a percentage of micro hardness loss (ΔPML) was determined according to Equation 2 below.
[수학식 2][Equation 2]
Figure PCTKR2021009914-appb-I000002
Figure PCTKR2021009914-appb-I000002
도 6a 및 6b를 참조하면, 과산화수소로 이루어진 대조군에서 미세 경도 손실율 (△PML) 이 16.43 ± 3.90으로 다른 실험군에 비해 높은 경도 손실이 일어난 것으로 나타난다. 이와 대조적으로, hCS0.50의 미세 경도 손실율은 -9.42 ± 2.62로, hCS1.00의 미세 경도 손실율은 -20.11 ± 3.80로, hCS2.00의 미세 경도 손실율은 -19.27 ± 2.76으로 나타난다. 즉, 이러한 실험 결과는, 수화된 칼슘 실리케이트의 첨가된 조성물의 경우, 치아 미백 효과와 동시에 치아 표면의 경도를 저하시키지 않았다는 것을 의미할 수 있다. Referring to FIGS. 6A and 6B , the fine hardness loss rate (ΔPML) was 16.43 ± 3.90 in the hydrogen peroxide control group, indicating that higher hardness loss occurred compared to other experimental groups. In contrast, the microhardness loss rate of hCS0.50 is -9.42 ± 2.62, the microhardness loss rate of hCS1.00 is -20.11 ± 3.80, and the microhardness loss rate of hCS2.00 is -19.27 ± 2.76. That is, these experimental results may mean that, in the case of the added composition of hydrated calcium silicate, the tooth whitening effect and the hardness of the tooth surface did not decrease at the same time.
이에, 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 치아 미백 및 치아 미세 경도 향상과 관련하여, 전체 조성물의 중량에 대하여 0.75 내지 2.25 wt%, 바람직하게 0.1 내지 2 wt%의 수화된 칼슘 실리케이트를 함유할 수 있으나, 이에 제한되는 것은 아니다. Accordingly, the composition for whitening teeth according to various embodiments of the present invention, in relation to tooth whitening and improvement of tooth microhardness, is 0.75 to 2.25 wt%, preferably 0.1 to 2 wt% of hydrated calcium silicate based on the weight of the total composition may contain, but is not limited thereto.
이상의 평가 4의 결과에 따르면, 수화된 칼슘 실리케이트를 함유한 본 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 치아 미백 시 치아의 표면 미세 경도 손실을 예방할 뿐만 아니라, 표면 미세 경도를 증가시키는 것으로 나타난다. 즉, 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 대조군의 과산화수소만을 함유한 치아 미백용 조성물만큼의 우수한 치아 미백 효과를 제공할 뿐만 아니라, 저하되지 않거나 강화된 치아 표면 미세 경도를 제공할 수 있다.According to the result of evaluation 4 above, the tooth whitening composition according to various embodiments of the present invention containing hydrated calcium silicate not only prevents loss of surface microhardness of teeth during tooth whitening, but also increases surface microhardness. appear. That is, the composition for whitening teeth according to various embodiments of the present invention not only provides an excellent tooth whitening effect as the composition for teeth whitening containing only hydrogen peroxide of the control group, but also provides non-deteriorating or enhanced tooth surface microhardness. have.
평가 5: 본 발명의 다양한 실시예에 따른 치아 미백용 조성물을 처리한 치아의 법랑질 표면 변화 관찰Evaluation 5: Observation of changes in the enamel surface of teeth treated with the tooth whitening composition according to various embodiments of the present invention
본 평가에서는, 전술한 평가 3의 방법과 동일한 방법으로 제작된 시편에 대하여 hCS0.25, hCS0.50, hCS1.00, hCS2.00의 치아 미백용 조성물을 처리한 후, 금-팔라듐 (gold-palladium) 으로 전처리를 수행하였다. 그 다음, SEM을 이용하여 3,000 배율 하에서 법랑질 표면이 관찰되었다. In this evaluation, after treating the tooth whitening composition of hCS0.25, hCS0.50, hCS1.00, and hCS2.00 with respect to the specimen prepared by the same method as in the above evaluation 3, gold-palladium (gold- palladium) was pre-treated. Then, the enamel surface was observed under 3,000 magnification using SEM.
도 7은 본 발명의 일 실시예에 따른 치아 미백용 조성물 내의 수화된 칼슘 실리케이트 함량에 따른 법랑질 표면 변화를 나타내는 결과이다. 7 is a result showing the enamel surface change according to the content of hydrated calcium silicate in the tooth whitening composition according to an embodiment of the present invention.
도 7을 참조하면, 대조군 (control) 의 법랑질 표면은 건강한 우치 법랑질 표면 (non-treatment) 과 비교하여 보았을 때 탈회된 양상이 나타난다. 이와 대조적으로, 실험군인 hCS1.00 및 hCS2.00의 법랑질 표면은 건강한 우치 법랑질 표면과 비교했을 때 탈회된 양상 없이, 유사한 형태를 유지하는 것으로 나타난다. 이러한 결과는, 치아 미백용 조성물 내의 수화된 칼슘 실리케이트에 의해, 법랑질 표면의 손상이 방지되었다는 것을 의미할 수 있다.Referring to FIG. 7 , the enamel surface of the control group showed a demineralized aspect when compared with the healthy dentate enamel surface (non-treatment). In contrast, the enamel surfaces of the experimental groups, hCS1.00 and hCS2.00, appeared to maintain a similar morphology without demineralization when compared to the healthy dentate enamel surface. These results may mean that damage to the enamel surface was prevented by the hydrated calcium silicate in the tooth whitening composition.
이상의 평가 5의 결과에 따르면, 수화된 칼슘 실리케이트를 함유한 본 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 치아 미백 시 법랑질 표면의 손상을 예방하는 것으로 나타난다. 즉, 발명의 다양한 실시예에 따른 치아 미백용 조성물은, 치아 미백에 따라 법랑질 표면 손상을 야기하는 과산화수소만을 함유한 치아 미백용 조성물과 대조적으로, 치아 미백 효과를 제공하면서 법랑질 표면 손상을 방지할 수 있는 효과가 있다. According to the result of evaluation 5 above, it appears that the tooth whitening composition according to various embodiments of the present invention containing hydrated calcium silicate prevents damage to the enamel surface during teeth whitening. That is, the tooth whitening composition according to various embodiments of the present invention can prevent enamel surface damage while providing a tooth whitening effect, in contrast to the tooth whitening composition containing only hydrogen peroxide, which causes enamel surface damage according to tooth whitening. there is an effect
이상의 다양한 평가 결과에 따르면, 본 발명은 치아의 표백 반응에 따른 낮은 pH 환경을 막지 못해 치아 표백 과정에 따른 법랑질 표면의 경도 저하가 일어나는 종래의 치아 미백용 조성물의 한계를 극복할 수 있다.According to the above various evaluation results, the present invention can overcome the limitations of the conventional tooth whitening composition in which a decrease in hardness of the enamel surface due to the tooth bleaching process occurs because the low pH environment caused by the bleaching reaction of the tooth cannot be prevented.
특히, 본 발명은 수화된 칼슘 실리케이트를 치아 미백 활성 물질과 함께 제공함에 따라, 미백 효과를 제공하면서 치아 미백 활성 물질을 단독으로 이용했을 때 보다 법랑질 표면의 미세 경도가 우수하고, 치아 탈회를 차단할 수 있다.In particular, in the present invention, as the hydrated calcium silicate is provided together with the tooth whitening active material, the microhardness of the enamel surface is superior to when the tooth whitening active material is used alone while providing a whitening effect, and tooth demineralization can be prevented have.
나아가, 본 발명은, 국제 표준 기구에서 규정한 치아 미백제의 필요 조건인, 치아 미백용 조성물 처치 후 비커스 표면 경도 감소가 10 미만인 조건을 만족할 수 있다. Furthermore, the present invention may satisfy the condition that the Vickers surface hardness decrease is less than 10 after treatment with the tooth whitening composition, which is a necessary condition for a tooth whitening agent stipulated by the international standard organization.
본 발명은, 치아 미백용 조성물로서의 효력이 유지되면서 표면 미세 경도 손실 예방 및 치아 탈회 차단 효과가 증가된, 치아 미백용 조성물 내의 각 조성들의 유효 함량을 제공할 수 있다.The present invention can provide an effective amount of each composition in the composition for whitening teeth, while maintaining the effectiveness as a composition for whitening teeth, preventing loss of surface microhardness and preventing tooth demineralization.
이상 첨부된 도면을 참조하여 본 발명의 실시 예들을 더욱 상세하게 설명하였으나, 본 발명은 반드시 이러한 실시 예로 국한되는 것은 아니고, 본 발명의 기술사상을 벗어나지 않는 범위 내에서 다양하게 변형 실시될 수 있다. 따라서, 본 발명에 개시된 실시 예들은 본 발명의 기술 사상을 한정하기 위한 것이 아니라 설명하기 위한 것이고, 이러한 실시 예에 의하여 본 발명의 기술 사상의 범위가 한정되는 것은 아니다. 그러므로, 이상에서 기술한 실시 예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다. 본 발명의 보호 범위는 아래의 청구범위에 의하여 해석되어야 하며, 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리범위에 포함되는 것으로 해석되어야 할 것이다.Although the embodiments of the present invention have been described in more detail with reference to the accompanying drawings, the present invention is not necessarily limited to these embodiments, and various modifications may be made within the scope without departing from the technical spirit of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical spirit of the present invention, but to explain, and the scope of the technical spirit of the present invention is not limited by these embodiments. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The protection scope of the present invention should be construed by the following claims, and all technical ideas within the scope equivalent thereto should be construed as being included in the scope of the present invention.

Claims (23)

  1. 수화된 칼슘 실리케이트 (hydrated calcium silicate) 및 치아 미백 활성 물질을 포함하고,hydrated calcium silicate and a tooth whitening active substance;
    상기 수화된 칼슘 실리케이트는, 철, 알루미늄, 마그네슘 및 황 중 적어도 하나를 더 포함하는, 치아 미백용 조성물.The hydrated calcium silicate further comprises at least one of iron, aluminum, magnesium and sulfur, a tooth whitening composition.
  2. 제1항에 있어서,According to claim 1,
    상기 수화된 칼슘 실리케이트는, 수화된 백색 포틀랜드 시멘트인, 치아 미백용 조성물.The hydrated calcium silicate is hydrated white Portland cement, a tooth whitening composition.
  3. 제1항에 있어서,According to claim 1,
    상기 수화된 칼슘 실리케이트는,The hydrated calcium silicate is
    상기 철, 상기 알루미늄, 상기 마그네슘 및 상기 황을 포함하는, 치아 미백용 조성물. The iron, the aluminum, comprising the magnesium and the sulfur, a tooth whitening composition.
  4. 제1항에 있어서,According to claim 1,
    상기 철의 함량은, The iron content is
    상기 수화된 칼슘 실리케이트의 전체 중량에 대하여 3 내지 7 wt%인, 치아 미백용 조성물.3 to 7 wt% based on the total weight of the hydrated calcium silicate, tooth whitening composition.
  5. 제1항에 있어서,According to claim 1,
    상기 알루미늄의 함량은, The aluminum content is
    상기 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%인, 치아 미백용 조성물.2 to 5 wt% based on the total weight of the hydrated calcium silicate, tooth whitening composition.
  6. 제1항에 있어서,According to claim 1,
    상기 마그네슘의 함량은, The magnesium content is
    상기 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%인, 치아 미백용 조성물.2 to 5 wt% based on the total weight of the hydrated calcium silicate, tooth whitening composition.
  7. 제1항에 있어서,The method of claim 1,
    상기 황의 함량은, The sulfur content is
    상기 수화된 칼슘 실리케이트의 전체 중량에 대하여 2 내지 5 wt%인, 치아 미백용 조성물.2 to 5 wt% based on the total weight of the hydrated calcium silicate, tooth whitening composition.
  8. 제1항에 있어서,The method of claim 1,
    상기 수화된 칼슘 실리케이트의 함량은The content of the hydrated calcium silicate is
    상기 치아 미백용 조성물의 전체 중량에 대하여 0.001 내지 5 wt%인, 치아 미백용 조성물.0.001 to 5 wt% based on the total weight of the composition for teeth whitening, the composition for teeth whitening.
  9. 제1항에 있어서,According to claim 1,
    상기 치아 미백 활성 물질의 함량은,The content of the tooth whitening active material is,
    상기 치아 미백용 조성물의 전체 중량에 대하여 95 내지 99.999 wt%인, 치아 미백용 조성물.95 to 99.999 wt% based on the total weight of the tooth whitening composition, the tooth whitening composition.
  10. 제1항에 있어서,According to claim 1,
    상기 수화된 칼슘 실리케이트의 입자의 직경은, 2 내지 3 ㎛인, 치아 미백용 조성물.The diameter of the particles of the hydrated calcium silicate, 2 to 3㎛, teeth whitening composition.
  11. 제1항에 있어서,According to claim 1,
    상기 치아 미백 활성 물질은, 과산화수소, 과산화칼슘, 카바마이드 퍼옥사이드 (carbamide peroxide), 퍼옥시산, 과산화탄산염, 과산화황산염, 과산화우레아, 과산화붕산염, 금속 아염소산염, 과산화피로인산나트륨 및 과산화탄산나트륨 중 적어도 하나인, 치아 미백용 조성물.The tooth whitening active material is at least one of hydrogen peroxide, calcium peroxide, carbamide peroxide, peroxy acid, peroxycarbonate, peroxysulfate, urea peroxide, peroxyborate, metal chlorite, sodium pyrophosphate and sodium percarbonate. One, a composition for whitening teeth.
  12. 제11항에 있어서,12. The method of claim 11,
    상기 치아 미백 활성 물질은, 과산화수소인, 치아 미백용 조성물. The tooth whitening active material is hydrogen peroxide, a tooth whitening composition.
  13. 제1항에 있어서,The method of claim 1,
    상기 치아 미백용 조성물의 pH 수준은 6.5 내지 7.5인, 치아 미백용 조성물. The pH level of the composition for teeth whitening is 6.5 to 7.5, the composition for teeth whitening.
  14. 제1항에 있어서,According to claim 1,
    상기 치아 미백용 조성물이 처리된 치아의 밝기는,The brightness of the teeth treated with the tooth whitening composition,
    상기 치아 미백 활성 물질만을 함유하는 치아 미백용 조성물이 처리된 치아의 밝기의 1.1 배 내지 1.5 배인, 치아 미백용 조성물.The tooth whitening composition containing only the tooth whitening active material is 1.1 times to 1.5 times the brightness of the treated tooth, the tooth whitening composition.
  15. 제1항에 있어서,The method of claim 1,
    상기 치아 미백용 조성물이 처리된 치아의 표면 미세 경도 (micro hardness) 는,The surface micro hardness of the tooth treated with the tooth whitening composition is,
    상기 치아 미백용 조성물이 처리되지 않은 치아의 표면 미세 경도의 1.1 배 내지 1.5 배인, 치아 미백용 조성물. The tooth whitening composition is 1.1 times to 1.5 times the surface microhardness of the untreated tooth, the tooth whitening composition.
  16. 수화된 칼슘 실리케이트를 준비하는 단계, 및preparing hydrated calcium silicate, and
    치아 미백용 조성물을 획득하도록, 상기 수화된 칼슘 실리케이트 및 치아 미백 활성 물질을 혼합하는 단계를 포함하고,mixing the hydrated calcium silicate and a tooth whitening active material to obtain a tooth whitening composition,
    상기 수화된 칼슘 실리케이트는, 철, 알류미늄, 마그네슘 및 황 중 적어도 하나를 더 포함하는, 치아 미백용 조성물의 제조 방법.The hydrated calcium silicate further comprises at least one of iron, aluminum, magnesium and sulfur, the method for producing a composition for whitening teeth.
  17. 제16항에 있어서,17. The method of claim 16,
    상기 수화된 칼슘 실리케이트를 준비하는 단계는,The step of preparing the hydrated calcium silicate,
    혼합물을 획득하도록, 상기 칼슘 실리케이트 및 물을 혼합하는 단계;mixing the calcium silicate and water to obtain a mixture;
    고형 혼합물을 획득하도록, 상기 혼합물을 경화하는 단계, 및curing the mixture to obtain a solid mixture, and
    수화된 칼슘 실리케이트 파우더를 획득하도록, 상기 고형 혼합물을 분쇄하는 단계를 포함하는, 치아 미백제 조성물의 제조 방법.A method for preparing a tooth whitening composition comprising the step of grinding the solid mixture to obtain a hydrated calcium silicate powder.
  18. 제16항에 있어서,17. The method of claim 16,
    상기 혼합하는 단계는,The mixing step is
    상기 수화된 칼슘 실리케이트 및 상기 치아 미백 활성 물질을 0.0001:99.9999 내지 5:95의 중량비로 혼합하는 단계를 포함하는, 치아 미백용 조성물의 제조 방법.A method for preparing a tooth whitening composition comprising mixing the hydrated calcium silicate and the tooth whitening active material in a weight ratio of 0.0001:99.9999 to 5:95.
  19. 제16항에 있어서,17. The method of claim 16,
    상기 수화된 칼슘 실리케이트는,The hydrated calcium silicate is
    상기 철, 상기 알루미늄, 상기 마그네슘 및 상기 황을 포함하는, 치아 미백용 조성물의 제조 방법.The iron, the aluminum, comprising the magnesium and the sulfur, a method for producing a composition for whitening teeth.
  20. 제1항 내지 제15항 중 어느 한 항에 따른 치아 미백용 조성물을 유효 성분으로 하는 치아 미백 기능성 식품.A tooth whitening functional food comprising the tooth whitening composition according to any one of claims 1 to 15 as an active ingredient.
  21. 제20항에 있어서, 상기 식품은 껌, 사탕, 엿, 젤리 및 카라멜 중 적어도 하나의 형태인, 치아 미백 기능성 식품.The tooth whitening functional food according to claim 20, wherein the food is in the form of at least one of gum, candy, candy, jelly and caramel.
  22. 제1항 내지 제15항 중 어느 한 항에 따른 치아 미백용 조성물을 유효 성분으로 하는, 치아 미백 기능성 치약.A tooth whitening functional toothpaste comprising the tooth whitening composition according to any one of claims 1 to 15 as an active ingredient.
  23. 제1항 내지 제15항 중 어느 한 항에 따른 치아 미백용 조성물을 유효 성분으로 하는, 치아 미백 기능성 구강 세정제.A tooth whitening functional mouthwash comprising the tooth whitening composition according to any one of claims 1 to 15 as an active ingredient.
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