WO2022030569A1 - Agent for improving quality of sleep - Google Patents

Abstract

The present invention addresses the problem of providing an agent for improving the quality of sleep, the agent being excellent in improving drowsiness on waking, and the like. This agent for improving the quality of sleep that solves the foregoing problem is characterized by containing, as an active ingredient, the oily fraction of the product of reduced-pressure steam distillation of Abies sachalinensis.

Description

Sleep quality improver

The present invention relates to a sleep quality improving agent.

In modern society, the number of people suffering from insomnia or sleep deprivation is increasing due to factors such as stress, unbalanced food diet, and environment. Sleep deprivation is said to cause obesity, hypertension, depression, diabetes, etc., and it is important to eliminate sleep deprivation. In recent years, attention has been paid not only to sleep time but also to sleep quality.

Sleep quality includes good sleep, deep sleep, and good mood after awakening, but frequent drowsiness during the day can lead to poor concentration and poor work and study performance. At the same time, it may cause accidents during work, so it is important to prevent drowsiness while waking up.

So far, as active ingredients having an effect of improving sleep quality, for example, a stillben compound and / or an olive extract (Patent Document 1), a volatile organic compound exhibiting the scent of the petals of a plant hamanasu (Patent Document 2), 3 hydroxy Butyric acid monomers (Patent Document 3), okla seed extracts derived from enzymatically decomposed okla seeds (Patent Document 4), and the like have been reported.

Japanese Unexamined Patent Publication No. 2014-24774 Japanese Unexamined Patent Publication No. 2015-81227 Japanese Unexamined Patent Publication No. 2019-172642 Japanese Unexamined Patent Publication No. 2020-48881

However, it was difficult to say that the above active ingredients can sufficiently improve the quality of sleep, such as suppressing drowsiness when waking up. Therefore, it is an object of the present invention to provide a sleep quality improving agent which is excellent in improving drowsiness when waking up.

As a result of various studies to find a component excellent in sleep quality improving effect such as improvement of sleepiness at the time of waking up, the present inventors can remarkably suppress sleepiness at the time of waking up by the oily fraction of the vacuum steam distillation of Todomatsu. They have found that they have an excellent effect of improving sleep quality, and have completed the present invention.

That is, the present invention is a sleep quality improving agent, which comprises a vacuum steam distilled product oily fraction of Abies sachalinensis as an active ingredient.

Further, the present invention is a sleep quality improving method in which the sleep quality improving agent is volatilized and applied.

By applying the sleep quality improving agent of the present invention, it is possible to fall asleep quickly, maintain sleep for a long time until morning without waking up halfway, and feel refreshed and relieved of fatigue. .. Furthermore, since drowsiness is suppressed during the daytime, it is possible to maintain concentration at work and stably exert high performance.

It is a figure which shows typically the structure of the microwave distillation apparatus used for obtaining the oily fraction of the reduced pressure steam distillation of Abies sachalinensis used as the active ingredient of the sleep quality improving agent of this invention. This is the scale used for VAS (Visual Analogue Scale). It is a figure which shows the state in which the pharmaceutical product was delivered about the stick-shaped sleep quality improving agent of this invention.

The sleep quality improving agent of the present invention contains the oily fraction of the vacuum steam distilled product of Abies sachalinensis as an active ingredient.

The part of Abies sachalinensis, which is the raw material, is not particularly limited, but the xylem and / or the leaf part is preferable from the viewpoint of effective utilization of thinned / pruned trees and excellent effect of improving sleep quality. Used.

The active ingredient used in the present invention is an oily fraction (essential oil) of a distillate obtained by steam distillation of Abies sachalinensis under reduced pressure. This decompressed steam distilled oil-based fraction contains monoterpenes at a high concentration without the need for concentration and purification, so it has a refreshing scent, a high scent preference, and improves sleep quality. It is also excellent in effect.

Note that the heating for distillation may be heating with a general heater or the like, but heating with microwaves is preferable in terms of heating efficiency, and it is particularly preferable to irradiate with microwaves without adding water for heating. By irradiating with microwaves, water molecules contained in the plant are directly heated to generate water vapor, which acts as a mobile phase to distill volatile components in the plant. Therefore, this distillation method is volatile. It is considered to include a vacuum distillation element depending on the boiling point of the component and a steam distillation element.

Distillate by such microwave irradiation can be obtained, for example, by using the apparatus shown in FIG. In the figure, 1 is a microwave distillation device, 2 is a distillation tank, 3 is a microwave heating device, 4 is a stirring splash, 5 is an airflow inflow tube, 6 is a distillate outflow tube, 7 is a cooling device, and 8 is a heating control. 9 is a pressure reducing pump, 10 is a pressure regulating valve, 11 is a pressure control device, 12 is a distillation object, and 13 is a distillation product.

In this device 1, microwaves are radiated from a microwave heating device 3 provided on the upper surface of the distillation tank 2 while the raw material Todomatsu, which is the object to be distilled 12, is placed in the distillation tank 2 and stirred by a stirring splash 4. And heat the raw material. The distillation tank 2 communicates with the airflow inlet 5 and the distillation outflow pipe 6. The airflow inflow pipe 5 introduces an inert gas such as air or nitrogen gas into the distillation tank 2, and this airflow is introduced from the lower part of the distillation tank 2. Further, the distillate outflow pipe 6 leads out the distillate from the raw material from the upper part of the distillation tank 2 to the outside. It was

Inside the distillation tank 2, the temperature and pressure are measured by a temperature sensor and a pressure sensor (both not shown) attached to the inside of the distillation tank 2, and the heating control device 8, the pressure control device 11, and the pressure control valve are measured. Each is adjusted via 10.

Further, the gaseous distillate flowing out from the distillation tank 2 via the distillate outflow pipe 6 is converted into a liquid by the cooling device 7 and obtained as the distillate 13. The distillate 13 contains an oil-based fraction 13a and an aqueous fraction 13b, of which the oil-based fraction 13a is fractionated and used as an active ingredient.

In the distillation, the pressure in the distillation tank 2 may be 3 to 95 kilopascals, preferably 3 to 40 kilopascals, more preferably 3 to 20 kilopascals, and the steam temperature at that time is 40 ° C. It reaches ~ 100 ° C. When the pressure is 3 kilopascals or less, the increase in vapor pressure of the volatile components in the plant is suppressed, and the vacuum distillation component due to the boiling point of each component is the main component, and the one with the lowest boiling point flows out in order from the steam distillation component. Therefore, it may not be preferable in that components having a boiling point higher than that of water cannot be efficiently extracted, and that many high boiling point components having low repellent efficiency and inferior fragrance preference are extracted. .. Further, if it is 95 kilopascals or more, the temperature of the raw material becomes high, so that energy loss is large and oxidation of the raw material is promoted, which may be unfavorable.

The distillation time may be about 0.2 to 8 hours, preferably about 0.4 to 6 hours. If it is 0.2 hours or less, a large amount of unextracted components in the plant will remain, and if it is 8 hours or more, the raw material will be in a state close to dryness, so that the extraction efficiency may decrease.

Further, the gas to be introduced into the distillation tank 2 may be air, but an inert gas such as nitrogen gas, helium gas, or argon gas is preferable, and the flow rate thereof is the flow rate per minute in the distillation tank 2. It may be about 0.001 to 0.1 times the capacity of the above.

As the active ingredient in the sleep quality improving agent of the present invention, the oily fraction of the vacuum steam distilled product of Abies sachalinensis obtained as described above can be used as it is, but if necessary, it is further concentrated by a conventional method. Alternatively, it may be purified and used.

The dosage form of the sleep quality improving agent of the present invention is not particularly limited, and may be, for example, a dosage form such as a liquid agent, a gel agent, a solid agent, a pump spray, or an aerosol.

When used as a liquid agent, the oily fraction of the vacuum steam distilled product of Abies sachalinensis can be used as it is as the sleep quality improving agent of the present invention, but it can also be diluted with an appropriate solvent. The content of the vacuum steam distilled oil fraction of Todomatsu when diluted with a solvent is preferably 0.1 to 30% by mass, more preferably 0.5 to 10 from the viewpoint of improving sleep quality and economic efficiency. It is by mass, more preferably 1.0 to 5% by mass.

Examples of solvents include water, methanol, ethanol, isopropanol, isobutanol, sec-butanol, tert-butanol, methyl cellosolve, ethyl cellosolve, alcohols such as glycerin; ethylene glycol dimethyl ether, 3-methoxy-1-butanol. , 3-Methoxy-3-methyl-1-butanol, 1,4-dioxane, ethers such as tetrahydrofuran; ketones such as acetone and methyl ethyl ketone; amides such as N, N-dimethylformamide and N, N-dimethylacetamide. , Dimethylsulfokiside and the like. These can be used alone or in combination of two or more.

In order to dissolve the oily fraction of the vacuum steam distilled product of Todomatsu in the above solvent, conventionally known anionic surfactants, cationic surfactants, nonionic surfactants or amphoteric surfactants can also be used.

Among the above-mentioned surfactants, examples of the anionic surfactant include higher fatty acid soap, soap base, metal soap, N-acyl-L-glutamate triethanolamine, N-acyl-L-sodium glutamate, and alkyl sulfate. Sodium, sodium alkylsulfonate, sodium polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene alkylphenyl ether phosphoric acid, coconut oil fatty acid methyl taurine sodium (N-cocoyl-N-methyl taurine sodium), One or a mixture of two or more of triethanolamine lauryl sulfate, sodium lauryl sulfate, sodium lauroyl sarcosin, sodium lauroylmethyl β-alanine, sodium lauroylmethyl taurine and the like can be used.

Examples of the cationic surfactant include lanolin fatty acid aminopropyl ethyl dimethyl ammonium chloride, alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, stearyl trimethyl ammonium chloride, and benzalkonium chloride. One kind or a mixture of two or more kinds of ammonium, benzethonium chloride and the like can be used.

Further, as nonionic surfactants, polyoxyethylene alkyl ether, polyoxyalkylene alkyl ether, polyoxyethylene hydrogenated castor oil ether, polyoxyethylene fatty acid ester, polyoxyethylene alkylphenyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid. Examples thereof include esters, sucrose fatty acid esters, glycerin fatty acid esters, polyoxyethylene polyoxypropylene block polymers, polyoxyethylene alkylamine ethers, fatty acid alkanolamides, and tertiary amine oxides. The polyoxyethylene alkyl ether has a polyoxyethylene chain of 3 to 18 preferably 7 to 12, the alkyl chain may be either linear or branched, and the alkyl chain length is preferably 8 to 22 and preferably 12 to 14. Examples of the fatty acid alkanolamide include coconut oil fatty acid, stearic acid, lauric acid monoethanolamide, and diethanolamide, and examples of the tertiary amine oxide include lauryldimethylamine oxide, coconut oil fatty acid dimethylamine oxide, and lauroyl. Examples thereof include aminopropyldimethylamine oxide, octyldimethylamine oxide, and myristyldimethylamine oxide.

Other fragrance components may be added to the sleep quality improving agent of the present invention. Examples of fragrance ingredients include l-menthol, dl-camphor, bornyl acetate, borneol, kamadulene, terpinen-4-ol, geraniol, citronellal, geranial, neral, hinokithiol, peppermint oil, eucalyptus oil, hiba oil, and katsura oil. , Bergamotte oil, terpinen oil, rose oil, uikyo, sage, cedar, hinoki, eucalyptus and other essential oils.

In the case of a gelling agent, a conventionally known gelling agent can be used, for example, carrageenan, gellan gum, agar, gelatin, guar gum, pectin, locust bean gum, xanthan gum, sodium alginate, cellulose derivative, dibenzylidene-D-. Examples thereof include sorbitol, hydroxypropylated polysaccharide, highly water-absorbent resin such as inulin stearate and sodium acrylate, aluminum octylate and the like, and one or more of these can be used in combination.

When solid agents are used, candelilla wax, honey wax, ceresin, microcrystallin wax, synthetic hydrocarbon wax and wax agents such as ethylene / propylene copolymer, vegetable oils such as olive oil, jojoba oil and macadamia oil, isotridecyl isononanoate, Fatty acid esters such as octyldodecyl isostearate and diisostearyl malate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capril capric acid), neopentyl glycol dioctanoate , Fatty acid glycols such as neopentyl glycol dicaprate, fatty acid glyceryl such as glyceryl diisostearate, glyceryl triisostearate, higher fatty acid alcohols such as coconut oil alkyl, octyldodecanol, liquid paraffin, liquid isoparaffin, polybutene, polyisobutene, fatty acid polyglyceryl, Use dilinol acid ester, rosin, rosin derivative, isostearic acid hydrogenated castor oil, (PPG-7 / succinic acid) copolymer, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, olefin oligomer, etc. to make an oily solid agent. Is preferable. The shape is not particularly limited, but a stick shape that can be applied to an application target is preferable.

Examples of other optional components include thickeners, ultraviolet absorbers, antioxidants, deodorants, and the like.

The sleep quality improving agent of the present invention is preferably applied by volatilizing or spraying into a space. By these methods, the active ingredient is inhaled from the nasal cavity or the like and exerts its effect. As a method of volatilizing the sleep quality improving agent of the liquid preparation type, a method of volatilizing as it is or in a state of being impregnated with an appropriate impregnated body, a method of sucking up the liquid agent and volatilizing it with a volatilizer, a method of using a lead diffuser, etc. Can be mentioned. In addition, a method of volatilizing using an appropriate volatilizer such as a room temperature volatilizer, a blower volatilizer using a fan, a heat volatilizer using a fire or a heat source, a pump spray, an aerosol, an ultrasonic vibrator, a pressurized liquid spray spray, etc. It is also possible to use a method of spraying using a pressurized air atomization spraying device or the like. Examples of the method of using the gel or solid agent include a method of allowing it to stand still and volatilizing it, or a method of applying it to bedding such as a pillow or the collar of a nightwear and volatilizing it from the coated portion. Among these methods, the efficiency of inhalation from the nasal cavity and the like is high, and from the viewpoint of economy, sustainability of the effect, and stability of the effect, it is preferable to volatilize by a method of applying to bedding such as a pillow. When the sleep quality improving agent of the present invention is applied or sprayed on bedding or the like, for example, about 20 to 200 mg of a vacuum steam distilled product oily fraction of Abies sachalinensis may be applied per 1 m ² . When spraying into the space, about 1 to 10 mg of the oil-based fraction of the reduced pressure steam distillation of Abies sachalinensis may be applied per 1 m ³ .

Further, the sleep quality improving agent of the present invention can also be applied as an external preparation. Examples of the external preparation include creams, external liquids, poultices, ointments, lotions, roll-ons and the like, and can be prepared according to a conventional method using any component usually blended in the external preparation. The dose and the like are not particularly limited and are appropriately set depending on the age, body weight and the like. For example, an external preparation containing about 1 to 10% by mass of the content of the vacuum steam distilled oil fraction of Abies sachalinensis is used for adults. However, it is sufficient to apply an amount of about 10 to 300 mg as an oil-based fraction of the reduced pressure steam distillation of Abies sachalinensis.

In this way, the effect of improving the quality of sleep is exhibited by inhaling the active ingredient through the nasal cavity or the like or percutaneously absorbing it. Improvements in sleep quality include shortening sleep onset latency (time required from awakening to falling asleep), suppressing midnight awakening to prevent waking up in the middle of the night, improving fatigue recovery to eliminate fatigue during awakening, and sleeping. It may include an increase in sleep time to maintain the state, an improvement in the feeling of lack of sleep time to eliminate the lack of sleep time felt during awakening, and an improvement in sleepiness during wake-up to suppress drowsiness during wake-up. In particular, it is important to prevent drowsiness when waking up, because inducing drowsiness during the day reduces concentration, performance such as work, and may cause accidents during work.

Hereinafter, the present invention will be described with reference to Examples, Production Examples, etc., but the present invention is not limited to these Examples, etc.

Manufacturing example 1
The leaves of Abies sachalinensis were crushed by a crushing type crusher (manufactured by KYB Corporation; FIG. 1), and about 50 kg thereof was put into a distillation tank of a microwave steam distillation apparatus. The pressure in the distillation tank was maintained under a reduced pressure condition of about 20 KPa while stirring (steam temperature was about 67 ° C.), and microwave irradiation was performed for 1 hour to obtain a distilled product, and the oily fraction (hereinafter referred to as "Abies sachalinensis essential oil") was obtained. ) Was collected. The amount of the essential oil of Abies sachalinensis obtained was 180 mL, and the ratio to the input sample was 0.34%.

Example 1
A stick-shaped oily solid preparation was prepared by the formulation shown in Table 1 below and the production method below.
(Prescription)

(Production method)
After all the components other than the Todomatsu essential oil of Production Example 1 were mixed and melted by heating, the Todomatsu essential oil of Production Example 1 was added and mixed, poured into a mold, cooled and molded into a stick shape. As shown in FIG. 3, this stick-shaped oily solid preparation (22) was attached to the feeding container (23) to form a stick-shaped preparation (21).

Trial example 1
Sleep quality improvement test (1):
The effect of improving the quality of sleep was tested using the stick-shaped preparation produced in Example 1 above.
(Test method)
Target audience: Elderly people (60 years old and over) who have difficulty falling asleep
Selection conditions:
・ No sleep disorder during treatment ・ Do not take sleeping pills on a daily basis ・ Be on the bed at about the same time every day ・ Pittsburgh sleep questionnaire score 6-8 points ・ Person without olfaction disorder The test was conducted on a total of 11 subjects, 7 males and 4 females who met the above conditions.

Apply 1 g (essential oil content 10 mg) of the stick-shaped preparation produced in Example 1 to the pillow of the subject on the surface opposite to the surface on which the sticker having an area of 7 cm ² is attached, and attach two of them to the pillow. I attached it. Using this Todomatsu essential oil treatment pillow, I had them go to bed around midnight, and the OSA sleep questionnaire (Yuka Yamamoto, Hideki Tanaka, Miki Takase, Katsuo Yamazaki, Kazuo Azumi, Shirakawa) between 7:00 am and 8:00 am the next day. Shuichiro: Development and standardization of the OSA sleep sensation questionnaire (MA version) for middle-aged and elderly people. A questionnaire was conducted based on Brain and Psychiatric Medicine 10: 401-409, 1999). As a control, a similar test was performed using a pillow coated with the stick-shaped preparation produced in Example 1 and not attached with a sticker. The interval between experiments was set to an interval of 2 days or more.

(Evaluation of sleep introspection when waking up)
The numerical values in Table 2 below were applied to the answers to the questions of the subjects, and the average value of all the subjects was calculated for each question item. The results are also shown in Table 2. Furthermore, based on the results in Table 2, factors in each psychological scale were evaluated. The results are shown in Table 3.

(Evaluation of scent impression (likes, dislikes, strength, etc.))
For each evaluation item of "pleasantness", "calmness", and "strength" by VAS (Visual Analogue Scale), the left end is set to 0 and the right end is set to 100 to indicate the position on the line segment, and VAS measurement is performed as the average value. The value was calculated. The results are shown in Table 4.

From Tables 2 and 3, the application of Abies sachalinensis essential oil to pillows can improve sleep quality in each of the factors of "wake-up sleepiness", "sleep onset and sleep maintenance", "recovery from fatigue" and "sleep time". Shown. By improving "sleep onset and sleep maintenance", shortening of "sleep onset latency" and suppression of "halfway awakening" can be realized. Further, as shown in Table 4, it was confirmed that the essential oil of Abies sachalinensis has an excellent scent preference.

Trial example 2
Sleep quality improvement test (2):
To 16 subjects of Test Example 1, 1 g (essential oil content 10 mg) of the stick-shaped preparation produced in Example 1 was applied to the surface opposite to the sticker having an area of 7 cm ² and applied. I stuck two sheets on the pillow. A polysomnography test was performed by Alice PDx (Phillips) while sleeping using this Abies sachalinensis essential oil-treated pillow. The determination of sleep stages such as awakening and sleep onset based on the polysomnography was performed according to the description in the literature (Akiko Noda, Yasuo Furuike: overnight sleep polygraphy, biomedical engineering 46 (2): 134-143, 2008). The average values for total sleep time, sleep efficiency, sleep onset time, and awakening time were calculated by the following formulas. In addition, as a control, a similar test was carried out using a pillow to which the stick-shaped preparation produced in Example 1 was applied and the sticker was not attached. The results are shown in Table 5.
(Calculation formula)
Total sleep time (minutes) = (time from sleep onset to final awakening (minutes))-(halfway awakening time (minutes))
Sleep efficiency (%) = ((time from sleep onset to final awakening (minutes)) / (total sleep time (minutes))) x 100
Sleep onset time (minutes) = Time from turn-off time to sleep onset (when any sleep stage appears) Midway awakening (minutes) = Total awakening time (minutes)

From Table 5, it was found that by applying the essential oil of Abies sachalinensis to the pillow, the total sleep time was longer and the sleep efficiency was improved as compared with the control. In addition, it was confirmed that the overall sleep quality was significantly improved because the time to fall asleep was shortened and the awakening time was also shortened.

Agent example 1
10% by mass of the essential oil of Abies sachalinensis of Production Example 1 was blended with 90% by mass of dipropylene glycol to produce a sleep quality improving agent for space spraying. When the obtained sleep quality improving agent for space spraying was sprayed into the bedroom using an ultrasonic atomizer (manufactured by Mikuni Co., Ltd.), it was possible to fall asleep well and fall asleep without waking up in the morning. Sleep was maintained for a long time, awakening was refreshing, and the quality of sleep was improved.

Agent example 2
50% by mass of 3-methoxy-3-methyl-1-butanol was blended with 50% by mass of the essential oil of Abies sachalinensis of Production Example 1 to produce a sleep quality improving agent for space spraying. When this sleep quality improving agent was transpired in the bedroom using a heat transpiring device (deodorant plug manufactured by ST Corporation), it was possible to fall asleep well and fall asleep for a long time without waking up. Sleep was maintained, awakening was refreshing, and sleep quality was improved.

Agent example 3
2% by mass of Abies sachalinensis essential oil of Production Example 1 was solubilized in water with 7% by mass of a surfactant (polyoxyethylene alkyl ether) to produce a sleep quality improving agent for space spraying. When I sprayed this sleep quality improving agent into the space using a commercially available pump spray and went to sleep, I was able to fall asleep well.

Agent example 4
0.1% by mass of the essential oil of Abies sachalinensis of Production Example 1 was dispersed in 99.9% by mass of water to produce a sleep quality improving agent for space spraying. When this sleep quality improving agent was sprayed on the bedroom using an ultrasonic atomizer (manufactured by Echotech Co., Ltd.), I was able to fall asleep well and sleep for a long time until morning without waking up. It was maintained, awakening was refreshing, and the quality of sleep was improved.

Agent example 5
3 g of κ-carrageenan as a gelling agent was dispersed in a mixture of 3.0 g of Todomatsu essential oil, 10 g of propylene glycol and 84 g of water of Production Example 1, heated and dispersed at about 60 ° C., and then filled in a cup-shaped container with an open top surface. , A gel-like sleep quality improver for space volatilization was produced by cooling and solidifying. When I installed this on the bedside of the bedroom and went to sleep while volatilizing it, I was able to fall asleep well and stay asleep for a long time until morning without waking up on the way, and the awakening was refreshing, and I was able to sleep. The quality was improved.

Agent example 6
2% by mass of Abies sachalinensis essential oil of Production Example 1 was solubilized in water with 5% by mass of a surfactant (polyoxyethylene alkyl ether) to produce a space volatilization sleep quality improving agent. I put this sleep quality improving agent in a container of deodorant power (registered trademark, manufactured by ST Corporation) in the room, and when I went to sleep while volatilizing it at the bedside of the bedroom, I could fall asleep well and go to sleep. Sleep was maintained for a long time until morning without waking up on the way, and the awakening was refreshing, and the quality of sleep was improved.

Agent example 7
The Todomatsu essential oil of Production Example 1 was filled in an aerosol container with a metering valve, automatically set in Suppat (registered trademark, manufactured by Estee Co., Ltd.), sprayed into the bedroom every 90 minutes, and went to sleep. I was able to fall asleep well, sleep for a long time until morning without waking up, and woke up refreshed, and the quality of sleep was improved.

The sleep quality improving agent of the present invention has an excellent sleep quality improving effect such as being able to suppress drowsiness when waking up, and is useful because it is also excellent in safety.

1 ……… Microwave distillation device 2 ……… Distiller 3 ……… Microwave heating device 4 ……… Stirring splash 5 ……… Airflow inflow pipe 6 ……… Distillate outflow pipe 7 ……… Cooling device 8 ……… Heating control device 9 ……… Decompression pump 10 ……… Pressure control valve 11 ……… Pressure control device 12 ……… Distillation target 13 ……… Distillation 21 ……… Stick-like formulation 22 ……… Stick-like oily solid formulation 23 ……… Feeding container

Claims (7)

1. A sleep quality improving agent characterized by containing an oily fraction of a vacuum steam distilled product of Abies sachalinensis as an active ingredient.
2. The sleep quality improving agent according to claim 1, which uses the xylem and / or leaves of Abies sachalinensis.
3. Claim 1 that the sleep quality improving agent is at least one selected from the group consisting of a sleep onset latency improving agent, a sleep onset latency improving agent, a sleep onset latency suppressing agent, a fatigue recovery feeling improving agent, and a sleeping time deficiency feeling improving agent. Or the sleep quality improving agent according to 2.
4. The sleep quality improving agent according to claim 3, wherein the sleep quality improving agent is a drowsiness improving agent when waking up.
5. The sleep quality improving agent according to any one of claims 1 to 4, which is a stick-shaped oily solid agent.
6. A method for improving sleep quality, wherein the sleep quality improving agent according to any one of claims 1 to 5 is volatilized and applied.
7. A method for improving sleep quality, wherein the sleep quality improving agent according to any one of claims 1 to 5 is continuously volatilized during sleep from the time of falling asleep.

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