WO2022023414A3 - Pharmaceutical microsphere compositions and methods - Google Patents

Pharmaceutical microsphere compositions and methods Download PDF

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Publication number
WO2022023414A3
WO2022023414A3 PCT/EP2021/071144 EP2021071144W WO2022023414A3 WO 2022023414 A3 WO2022023414 A3 WO 2022023414A3 EP 2021071144 W EP2021071144 W EP 2021071144W WO 2022023414 A3 WO2022023414 A3 WO 2022023414A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microsphere compositions
pharmaceutical microsphere
pharmaceutical
compositions
Prior art date
Application number
PCT/EP2021/071144
Other languages
French (fr)
Other versions
WO2022023414A2 (en
Inventor
Ian LANGER
Ronald E. Betts
Beatris Flores
Original Assignee
Biotronik Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotronik Ag filed Critical Biotronik Ag
Priority to EP21763236.3A priority Critical patent/EP4188335A2/en
Publication of WO2022023414A2 publication Critical patent/WO2022023414A2/en
Publication of WO2022023414A3 publication Critical patent/WO2022023414A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

This application relates generally to the field of materials and manufacturing methods involving microsphere compositions and pharmaceutical applications related thereto.
PCT/EP2021/071144 2020-07-29 2021-07-28 Pharmaceutical microsphere compositions and methods WO2022023414A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21763236.3A EP4188335A2 (en) 2020-07-29 2021-07-28 Pharmaceutical microsphere compositions and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063058312P 2020-07-29 2020-07-29
US63/058,312 2020-07-29
EP20202624 2020-10-19
EP20202624.1 2020-10-19

Publications (2)

Publication Number Publication Date
WO2022023414A2 WO2022023414A2 (en) 2022-02-03
WO2022023414A3 true WO2022023414A3 (en) 2022-07-14

Family

ID=80037709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/071144 WO2022023414A2 (en) 2020-07-29 2021-07-28 Pharmaceutical microsphere compositions and methods

Country Status (2)

Country Link
EP (1) EP4188335A2 (en)
WO (1) WO2022023414A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260273A1 (en) * 2001-06-07 2005-11-24 Chinea Vanessa I Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
WO2013182503A1 (en) * 2012-06-08 2013-12-12 Biotronik Ag Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods
WO2014053974A1 (en) * 2012-10-01 2014-04-10 Aizant Drug Research Solutions Private Limited Pharmaceutical compositions of sirolimus
CN104707170A (en) * 2015-04-02 2015-06-17 山东大学齐鲁医院 Method for preparing rapamycin medicine loaded on nanometer HAp (hydroxyapatite) layer on surface of titanium material

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260273A1 (en) * 2001-06-07 2005-11-24 Chinea Vanessa I Applicatin of a bioactive agent in a solvent composition to produce a target particle morphology
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
WO2013182503A1 (en) * 2012-06-08 2013-12-12 Biotronik Ag Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods
WO2014053974A1 (en) * 2012-10-01 2014-04-10 Aizant Drug Research Solutions Private Limited Pharmaceutical compositions of sirolimus
CN104707170A (en) * 2015-04-02 2015-06-17 山东大学齐鲁医院 Method for preparing rapamycin medicine loaded on nanometer HAp (hydroxyapatite) layer on surface of titanium material

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAE-WON YOON ET AL: "Establishment of a solvent map for formation of crystalline and amorphous paclitaxel by solvent evaporation process", KOREAN JOURNAL OF CHEMICAL ENGINEERING, SPRINGER US, BOSTON, vol. 28, no. 9, 29 June 2011 (2011-06-29), pages 1918 - 1923, XP019947266, ISSN: 1975-7220, DOI: 10.1007/S11814-011-0060-2 *
RICCIUTELLI M ET AL: "Evaluation of rapamycin chemical stability in volatile-organic solvents by HPLC", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, ELSEVIER B.V, AMSTERDAM, NL, vol. 41, no. 3, 7 June 2006 (2006-06-07), pages 1070 - 1074, XP028005390, ISSN: 0731-7085, [retrieved on 20060607], DOI: 10.1016/J.JPBA.2006.02.009 *

Also Published As

Publication number Publication date
WO2022023414A2 (en) 2022-02-03
EP4188335A2 (en) 2023-06-07

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