WO2022015810A3 - Biomarkers of trpml1 activation - Google Patents

Biomarkers of trpml1 activation Download PDF

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Publication number
WO2022015810A3
WO2022015810A3 PCT/US2021/041565 US2021041565W WO2022015810A3 WO 2022015810 A3 WO2022015810 A3 WO 2022015810A3 US 2021041565 W US2021041565 W US 2021041565W WO 2022015810 A3 WO2022015810 A3 WO 2022015810A3
Authority
WO
WIPO (PCT)
Prior art keywords
trpml1
biomarkers
activation
kits
modulation
Prior art date
Application number
PCT/US2021/041565
Other languages
French (fr)
Other versions
WO2022015810A2 (en
Inventor
John William ANNAND
Philip Alan BERGMAN
Anna S. BLAZIER
Rohini SIDHU
Xuntian JIANG
JR. Timothy John MARSH
Daniel Scott Ory
Original Assignee
Casma Therapeutics, Inc.
Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Casma Therapeutics, Inc., Washington University filed Critical Casma Therapeutics, Inc.
Publication of WO2022015810A2 publication Critical patent/WO2022015810A2/en
Publication of WO2022015810A3 publication Critical patent/WO2022015810A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present disclosure pertains to biomarkers of TRPML1 modulation and methods and kits using the same.
PCT/US2021/041565 2020-07-17 2021-07-14 Biomarkers of trpml1 activation WO2022015810A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063053416P 2020-07-17 2020-07-17
US63/053,416 2020-07-17

Publications (2)

Publication Number Publication Date
WO2022015810A2 WO2022015810A2 (en) 2022-01-20
WO2022015810A3 true WO2022015810A3 (en) 2022-03-31

Family

ID=79556138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/041565 WO2022015810A2 (en) 2020-07-17 2021-07-14 Biomarkers of trpml1 activation

Country Status (1)

Country Link
WO (1) WO2022015810A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170089872A1 (en) * 2014-04-08 2017-03-30 Metabolon, Inc. Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
US20190248764A1 (en) * 2016-06-29 2019-08-15 CalyGene Biotechnolgy, Inc. Piperazine derivatives as trpml modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170089872A1 (en) * 2014-04-08 2017-03-30 Metabolon, Inc. Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
US20190248764A1 (en) * 2016-06-29 2019-08-15 CalyGene Biotechnolgy, Inc. Piperazine derivatives as trpml modulators

Also Published As

Publication number Publication date
WO2022015810A2 (en) 2022-01-20

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