WO2022001911A1

WO2022001911A1 - Eyedrop application device

Info

Publication number: WO2022001911A1
Application number: PCT/CN2021/102593
Authority: WO
Inventors: 吴明翰; 吴思仪
Original assignee: 吴明翰; 吴思仪
Priority date: 2020-07-03
Filing date: 2021-06-28
Publication date: 2022-01-06
Also published as: CN213910835U; JP3242382U

Abstract

Provided is an eyedrop application device (10), comprising a body (12), wherein the body (12) has a surface (16) for receiving eyedrop droplets (14), and the body (12) is made of a porous material having a pore density of 30-150. The surface (16) of the body (12) may be provided with a recess (24) for retaining some of the droplets (14) received by the surface (16), such that the easiness and safety of using the eyedrops can be ensured, and a user can further easily inject a trace amount of eyedrops and eyedrops with a reduced concentration into the eyes (32).

Description

Applicator for eye drops

technical field

The present invention relates to a device for applying eye drops, in particular, to a device that allows users to conveniently apply micro eye drops and/or low concentration eye drops.

Background technique

In recent years, the safety of children's medication has received more and more attention from the society. Children are more sensitive to drug dose response, and different ages, or different weights of the same age, the dose of drugs should be different, too little dose will not achieve the therapeutic effect, and too much dose will only increase side effects. However, general liquid medicines (especially bottled eye drops) cannot be reduced according to the patient's age or weight, resulting in no corresponding eye drops for children. Specifically, a drop of eye drops in a bottle is about 30-50 microliters, which is more than the amount that ordinary people need to use, especially the corresponding amount for young children. Excessive use of eye drops in children for a long time may cause side effects such as increased intraocular pressure, allergies, photophobia, or more discomfort in the eyes. In addition, the concentration of the active ingredient in the commercially available eye drops is generally controlled within a certain range, which makes it impossible for users who need low concentration to apply it directly. Usually, it needs to be diluted to a low concentration with the assistance of medical staff, causing trouble and inconvenience in use.

There is currently a lack of a simple eye drop application device that allows users to easily obtain micro and/or reduced concentrations of eye drops for application.

SUMMARY OF THE INVENTION

Therefore, the purpose of the present invention is to provide an application device for eye drops, which has a simple structure and convenient operation, can overcome the defects of the prior art, and is more convenient to apply the eye drops.

In order to achieve the above purpose, the present invention discloses a device for applying eye drops, comprising a body, characterized in that: the body has a first surface for receiving the eye drops, the body is composed of a pore density of 30-150 and a pore density of 5-50 Made of porous material between Shore hardness.

Wherein, the body is made of a non-absorbent sponge, and the sponge has a Shore hardness between 10-30.

Wherein, the first surface of the main body is provided with a groove to retain a part of the eye drops received by the first surface.

Wherein, the body is a thin rod body with a circular cross section, the first surface has a first diameter, the first diameter is between 3 and 20 mm, the groove has a second diameter, the second diameter The diameter is between 0.5-2mm.

Wherein, the first diameter is between 4 and 20 mm.

Wherein, the body further has a second surface opposite to the first surface and a through hole passing through the first surface and the second surface, the through hole has an opening located on the first surface to retain the first surface Part of the received eye drops.

Wherein, the diameter of the perforation is 0.5-2mm.

Wherein, the main body includes a front end and a rear end separated from the front end, the first surface is formed on the front end, the rear end of the main body is provided with a joint part, and a handle is combined with the joint part for the user to hold .

Wherein, the joint portion is a notch.

Through the above structure, the application device of the present invention can allow the user to conveniently obtain a small amount of eye drops and easily dilute the eye drops to reduce the concentration for use, so as to ensure the convenience and safety of the use of the eye drops, which can be convenient A user (eg, a child) instills a small amount of eye drops and a reduced concentration of eye drops into the eyes.

Other objects, advantages and features of the present invention will be understood from the following detailed description of the preferred embodiments with reference to the accompanying drawings.

Description of drawings

Figure 1: A perspective view of an applicator according to a first embodiment of the present invention.

FIG. 2 : shows a cross-sectional view of the applicator of FIG. 1 .

FIG. 3 : shows a partial enlarged view of the applicator of FIG. 2 .

Figure 4: A schematic diagram showing the application of drops of eye drops from a container to the applicator of Figure 1 .

Figure 5: A schematic diagram showing the applicator of Figure 4 receiving a droplet.

Figure 6: is a cross-sectional view similar to Figure 3, showing a second embodiment of the applicator of the present invention.

Figure 7: A schematic diagram showing the application of eye drops received by the applicator of Figure 1 to a user's eye.

Figure 8: Cross-sectional view of an applicator of a third embodiment of the present invention.

Figure 9: A schematic diagram showing the applicator of Figure 8 receiving a droplet.

Figure 10: An exploded view of the applicator of the fourth embodiment of the present invention.

Figure 11: A schematic diagram showing the applicator of Figure 10 receiving eyedrops droplets.

Figure 12: A schematic diagram showing the pouring of a portion of a droplet received by the applicator of Figure 11 .

FIG. 13 : Schematic diagram showing the application of at least one drop of diluent onto the applicator of FIG. 12 .

Figure 14: A schematic diagram showing the application of eye drops received by the applicator of Figure 13 to a user's eye.

detailed description

Now it is only an example but not a specific embodiment for limitation, and the preferred content of the present invention is described as follows with reference to the accompanying drawings:

FIGS. 1 to 4 show an eyedrop application device 10 according to an embodiment of the present invention. The application device 10 includes a body 12 , and the body 12 has a first surface 16 for receiving eyedrops 14 . The body 12 is made of a porous material, the porous material has a pore density (pores per inch; PPI) of 30-150, so that the droplets 14 carried on the first surface 16 can be affected by adhesion and surface tension. And become a suspension (see Figure 5). When the pore density is less than 30, the eyedrops 14 easily flow into the pores of the first surface 16 , and when the pore density is greater than 150, the eyedrops 14 easily slip off the first surface 16 . In addition, the body 12 is selected from hydrophobic materials. Furthermore, the Shore hardness of the material of the body 12 is between 5-50, preferably less than 30, more preferably between 10-30. The body 12 with Shore hardness between 10-30 can improve the safety of the applicator 10 in use, and the user's eyes will not feel uncomfortable when the body 12 is directly contacted. In one embodiment, the body is selected from low density polyether, polyeether, polyvinyl alcohol, polyester or foamed plastic polymer.

In this embodiment, the body 12 is a thin rod body, which is made of a non-absorbent sponge (low density polyether) and has a circular cross section. The body 12 includes a front end 18 and a rear end 20 . The first surface 16 is formed on the end surface of the front end 18 and is a plane, and the end surface of the rear end 20 has a second surface 22 . The first surface 16 has a first diameter (d1), in a preferred embodiment, the first diameter (d1) is between 3 and 20 mm. In one embodiment, the first diameter (d1) is between 4 and 20 mm.

In this embodiment, the first surface 16 of the main body 12 is provided with a groove 24 , and the groove 24 has a circular cross section and a U-shaped longitudinal section, as shown in FIG. 3 . The groove 24 has a second diameter (d2) smaller than the first diameter (d1). The provision of the grooves 24 can increase the surface area of the first surface 16 so that at least some of the droplets 14 can adhere to the walls of the grooves 24 and remain on the first surface 16 . The size and shape of the first surface 16 and the groove 24 can be changed according to requirements. In a preferred embodiment, the second diameter (d2) is less than 5 mm and between 0.5-2 mm, so that the grooves 24 can retain 0.1-95% of the micro liquid in the total volume of the droplets 14 received by the first surface 16 drop. In another possible embodiment, the groove 24 has a generally V-shaped longitudinal section, as shown in FIG. 6 .

4 and 5 show an embodiment of the applicator 10 to obtain the eyedrops 14 . In practice, a container (eg, an eye drop bottle) 26 containing the eye drops is positioned above the first surface 16 of the body 12 (eg, 1 cm above the first surface 16 ), and the eye drops 14 are removed from the container The drip opening 27 of 26 drips onto the first surface 16 of the body 12 . FIG. 7 shows an application example in which eyedrops 14 obtained by the applicator 10 are dispensed into a user's eye. During the dispensing process, the user can directly touch the droplet 14 on the first surface 16 with his eyes in a posture of lowering his head without the need for a traditional way of raising his head. If the user holds the applicator 10 upside down or horizontally with the ground, some of the droplets 14 slide off the first surface 16, but the porous pores and/or grooves 24 of the first surface 16 are provided. , at least a portion of the droplets 14 will remain on the first surface 16 enough for the user to dispense medicine. Alternatively, the user can also deliberately slide most of the droplets 14 away (slightly swirl) to leave a small amount of the droplets 14 for application; then, the user can use the index finger to pull down the lower eyelid 30, and then pull the first The surface 16 is adjacent to the eye 32 such that the droplets 14 retained by the first surface 16 point into the groove between the white of the eye and the lower eyelid to complete the application of the eye drop. It should be noted that the droplets obtained by the applicator 10 are not limited to eye drops, but are also applicable to other droplets.

During the dispensing process, regardless of the inclination angle of the first surface 16, the droplets 14 will not all slide off the first surface 16, and the remaining droplets 14 are still available for use. That is, based on experimental confirmation, when the first surface 16 of the body 12 is tilted and the droplet 14 is poured and the droplet 14 slides off the first surface 16, the first surface 16 has a pore density of 30-150 PPI or The grooves 24 are arranged to retain a portion of the droplet 14 on the first surface 16 for application.

As shown in the data table of the experiment below, the average weight of each droplet is 44+/-9uL, and the weight of the remaining droplet after being poured out is 5+/-2uL, accounting for 11.364%.

data sheet

When low concentrations of eye drops are required, a diluent may be added to the first surface 16 to mix with the remaining droplets 14 . In one embodiment, a drop of diluent (such as distilled water) is added to the obtained droplets of residual eye drops, and the average weight of the diluted droplets is 44uL, thus, the concentration (mg/dl) after dilution becomes 5/(44+ 5), the proportion is 0.102, which can be diluted by about one tenth. Two drops of diluent (droplet weight about 88uL) can also be added to the obtained residual eye drops, the concentration becomes 5/(88+5), the ratio is 0.049, and it can be diluted by about one-twentieth. Alternatively, after adding a drop of diluent, the diluted drop can be discarded first and a small amount of low-concentration eye drops can be retained, and then a drop of diluent is added, and the ratio is about 0.010, which can be diluted by less than one-thirtieth. . Accordingly, the applicator 10 of the present invention can allow the user to conveniently obtain micro eye drops for application, especially the micro eye drops less than 28 microliters. The potion works best. In addition, the applicator 10 of the present invention can also allow the user to dilute it to obtain eye drops with a reduced concentration, so as to improve the convenience of use. In a possible use embodiment, the applicator 10 of the present invention can be delivered to a patient for use by a physician, since the physician knows the correct dosage and concentration required by the patient.

FIGS. 8 and 9 show the applicator 10 according to the third embodiment of the present invention. In this embodiment, the body 12 has a through hole 34 extending from the front end 18 to the rear end 20 , and the through hole 34 has a hole located on the first surface 16 . The opening 24a has the function of receiving eye drops, so that a structure similar to the groove 24 is formed on the first surface 16, and a part of the droplet 14 received by the first surface 16 can be retained by the hole wall of the perforation 34 .

FIG. 10 shows the applicator 10 according to the fourth embodiment of the present invention. In this embodiment, the main body 12 is made of a porous material (such as a non-absorbent sponge) as a cylinder, and the rear end 20 of the main body 12 is provided with a joint 36 , the joint portion 36 is a notch. A handle 38 is detachably coupled to the joint 36 for the user to hold. The used body 12 can be removed from the handle so that a new body 12 can be attached to the handle 38 the next time it is used. Figure 11 shows droplets 14 of eyedrops dripping from container 26 onto first surface 16 of this embodiment. FIG. 12 shows the user tilting the first surface 16 of the body 12 so that the droplets 14 slide off the first surface 16 . Figure 13 shows the addition of a diluent 40 to the first surface 16 to mix with the remaining droplets 14 to obtain a reduced concentration of eye drops. FIG. 14 shows the application of the user pulling down the lower eyelid 30 with the index finger 28 and applying the droplet 14 retained on the first surface 16 into the eye 32 without looking up. In practice, the user can see the position of the handle 38 , so there is no fear of the body 12 hitting the eyes, which can increase the safety of use. In another possible embodiment, the body 12 is made of a porous material (eg, a sponge that does not absorb water) as a sheet.

The present invention further provides an application method for eye drops, the method comprising providing an application device 10 as in the above-mentioned embodiment; dropping eye drops droplets 14 on the first surface 16 of the body 12 of the application device 10; letting the eye drops A part of the droplet 14 slips away from the first surface 16 to retain 0.1-95% volume percent of the droplet 14 on the first surface 16; and the droplet 14 is dropped into a use the eyes of the person.

In the application method of the present invention, at least one drop of the diluent 40 can be dropped onto the first surface 16 and mixed with the micro drop 14 to form a first dilution liquid before the micro drop 14 is dropped into the eyes of the user; A portion of the first dilution liquid is slid away from the first surface 16 and a first trace amount of dilution liquid is left on the first surface 16 ; then, at least one drop of the dilution liquid 40 is dropped on the first surface 16 to connect with the first surface 16 . The micro dilution potion is mixed into a second dilution potion; after that, a part of the second dilution potion is slipped off from the first surface 16 and a second micro dilution potion is left on the first surface 16, and finally the second micro dilution potion is The potion is transferred to the user's eyes.

The above are the detailed descriptions and drawings of the preferred embodiments of the present invention, and are not intended to limit the present invention. The entire scope of the present invention should be based on the following patent scope. and similar structures should be included in the present invention.

Claims

An application device for eye drops, comprising a body, characterized in that: the body has a first surface for receiving the eye drops, and the body is made of a porous material with a pore density of 30-150 and a Shore hardness of 5-50 production.
The device for applying eye drops according to claim 1, wherein the body is made of a non-absorbent sponge, and the sponge has a Shore hardness of 10-30.
The device for applying eye drops according to claim 1 or 2, wherein the first surface of the main body is provided with a groove to retain a part of the eye drops received by the first surface.
The device for applying eye drops according to claim 3, wherein the body is a thin rod body with a circular cross-section, the first surface has a first diameter, and the first diameter is between 3 to 20 mm In between, the groove has a second diameter, and the second diameter is between 0.5-2 mm.
The device for applying eye drops according to claim 1 or 2, wherein the body further has a second surface opposite to the first surface and a perforation penetrating through the first surface and the second surface, the The perforation has an opening in the first surface to retain a portion of the eye drops received by the first surface.
The device for applying eye drops according to claim 5, wherein the diameter of the perforation is 0.5-2 mm.
The device for applying eye drops according to claim 1 or 2, wherein the main body comprises a front end and a rear end separated from the front end, the first surface is formed at the front end, and the rear end of the main body is provided with a The joint part, a handle is combined with the joint part for the user to hold.
The device for applying eye drops according to claim 5, wherein the main body comprises a front end and a rear end separated from the front end, the first surface is formed at the front end, and the rear end of the main body is provided with a joint portion , a handle is combined with the joint for the user to hold.
The device for applying eye drops according to claim 8, wherein the joint portion is a notch.
The device for applying eye drops according to claim 1, wherein the body is a thin rod body with a circular cross-section, the first surface has a first diameter, and the first diameter is between 4 and 20 mm between.