WO2021252891A3 - In silico generated target lists - Google Patents
In silico generated target lists Download PDFInfo
- Publication number
- WO2021252891A3 WO2021252891A3 PCT/US2021/037004 US2021037004W WO2021252891A3 WO 2021252891 A3 WO2021252891 A3 WO 2021252891A3 US 2021037004 W US2021037004 W US 2021037004W WO 2021252891 A3 WO2021252891 A3 WO 2021252891A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dysfunctional
- methods
- cells
- preferentially expressed
- markers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Genetics & Genomics (AREA)
- Physiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention relates to methods for identifying gene targets by interrogating genes preferentially expressed with dysfunctional T cell markers, systems for generating an in silico target list preferentially expressed with dysfunctional T cell markers and with or without regulatory T cells (Treg) markers, methods of treating cancer by interrogating genes preferentially expressed with dysfunctional T cell markers and with or without Treg markers, methods of treating cancer by interrogating genes preferentially expressed by T effector cells and not by dysfunctional T cells or regulatory T cells (Tregs), and methods of treating autoimmune disease.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063037687P | 2020-06-11 | 2020-06-11 | |
US63/037,687 | 2020-06-11 | ||
US202063040600P | 2020-06-18 | 2020-06-18 | |
US63/040,600 | 2020-06-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021252891A2 WO2021252891A2 (en) | 2021-12-16 |
WO2021252891A3 true WO2021252891A3 (en) | 2022-01-20 |
Family
ID=76744990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2021/037004 WO2021252891A2 (en) | 2020-06-11 | 2021-06-11 | In silico generated target lists |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2021252891A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180100201A1 (en) * | 2015-06-29 | 2018-04-12 | The Broad Institute Inc. | Tumor and microenvironment gene expression, compositions of matter and methods of use thereof |
WO2018209324A2 (en) * | 2017-05-11 | 2018-11-15 | The Broad Institute, Inc. | Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof |
-
2021
- 2021-06-11 WO PCT/US2021/037004 patent/WO2021252891A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180100201A1 (en) * | 2015-06-29 | 2018-04-12 | The Broad Institute Inc. | Tumor and microenvironment gene expression, compositions of matter and methods of use thereof |
WO2018209324A2 (en) * | 2017-05-11 | 2018-11-15 | The Broad Institute, Inc. | Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2021252891A2 (en) | 2021-12-16 |
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