WO2021228099A1

WO2021228099A1 - Delivery pipes, guide pipes and tissue repair devices

Info

Publication number: WO2021228099A1
Application number: PCT/CN2021/093102
Authority: WO
Inventors: Haishan Wang; Jiaqiang JIANG; Qifeng Yu; Tao Qin
Original assignee: Shanghai Newmed Medical Co., Ltd.
Priority date: 2020-05-11
Filing date: 2021-05-11
Publication date: 2021-11-18

Abstract

A delivery pipe (100) of a tissue clamping device (200) and a tissue repair device (10) are disclosed. The delivery pipe (100) of the tissue clamping device (200) may include an outer pipe (110), an inner core (120), and a traction mechanism (130). The outer pipe (110) may be sleeved outside the inner core (120). The outer pipe (110) may include a first pipe body (111) and a second pipe body (112), one end of the first pipe body (111) may be connected to the tissue clamping device (200), another end of the first pipe body (111) may be connected to the second pipe body (112). The traction mechanism (130) may be configured to control the first pipe body (111) to bend.

Description

DELIVERY PIPES, GUIDE PIPES AND TISSUE REPAIR DEVICES

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to Chinese Patent Application No. 202010391597.2, filed on May 11, 2020, and Chinese Patent Application No. 202120177336.0, filed on January 22, 2021, the contents of each of which are hereby incorporated by reference.

TECHNICAL FIELD

The present disclosure relates to a medical device, in particular, to delivery pipes, guide pipes and tissue repair devices.

BACKGROUND

In the minimanlly invasive repair surgery, it is usually necessary to clamp and fix the tissue by a tissue clamping device. Valves are membrane-like structures that can be opened and closed in organs of humans or some animals. For example, there are four valves in the human's heart, including an aortic valve, a pulmonary valve, a mitral valve, and a tricuspid valve. Taking the human's mitral valve as an example, the mitral valve is located between the left atrium and the left ventricle. When the left ventricle contracts, the mitral valve, acting as a check valve, tightly closes an atrioventricular opening to prevent blood from flowing back from the left ventricle to the left atrium. However, if the mitral valve is diseased, it may be difficult for the mitral valve to close the left ventricle when it contracts, causing the left atrium to receive a large amount of reflux blood. This may lead to a sharp rise in pressures of the left atrium and the pulmonary vein, an increase in the load of the left ventricular diastolic volume, and further lead to a series of pathological changes such as left ventricular enlargement and pulmonary hypertension. Eventually, it may result in clinical manifestations such as heart failure, arrhythmia, etc., which may be life-threatening in severe cases. A tissue repair device can be used to repair the diseased mitral valve, for example, clamp valves of the mitral valve, so that one large hole formed by the valves changes to two small holes, and thus a regurgitation area is reduced, thereby effectively preventing mitral regurgitation. Similarly, the tissue repair device can also be applied to the repair of the heart's tricuspid valve and other valves, achieving the same effect of reducing the regurgitation area by clamping both valve leaflets. The tissue repair device may include a delivery pipe, in the process of valve repair, the delivery pipe may be configured to manipulate the tissue clamping device to achieve the repair and delivery of the valve.

SUMMARY

According to an aspect of the present disclosure, a delivery pipe of a tissue clamping device is provided. The delivery pipe of a tissue clamping device may include an outer pipe, an inner core, and a traction mechanism. The outer pipe may be sleeved outside the inner core. The outer pipe may include a first pipe body and a second pipe body, one end of the first pipe body may be connected to the tissue clamping device, another end of the first pipe body may be connected to the second pipe body. The traction mechanism may be configured to control the first pipe body to bend.

In some embodiments, one side of the first pipe body may be equipped with a plurality of first notches along a length direction of the first pipe body, the first pipe body may be able to bend to an opening direction of the plurality of first notches.

In some embodiments, opening sizes of the plurality of first notches may be the same or unidentical.

In some embodiments, an opening size of a first notch close to the one end of the first pipe body may be less than an opening size of a first notch close to the another end of the first pipe body.

In some embodiments, the first pipe body may be integrally formed by cutting a shape memory alloy pipe.

In some embodiments, the traction mechanism may include a first traction filament, one end of the first traction filament may be fixedly connected to one end of the first pipe body. one side of the inner core may be equipped with a groove in a length direction of the inner core, the first traction filament may be disposed in the groove.

In some embodiments, the traction mechanism may further include a spring tube, the spring tube may be sleeved on a portion of the first traction filament corresponding to the second pipe body.

In some embodiments, the traction mechanism may further include a blocking member, the blocking member may be sleeved on the first traction filament and fixed at a connection of the first pipe body and the second pipe body to block the spring tube.

In some embodiments, the connection of the first pipe body and the second pipe body may be equipped with a connection member, the blocking member may be fixedly connected to the connection member.

In some embodiments, the one end of the first pipe body may be connected to the tissue clamping device through a delivery connection member.

In some embodiments, the inner core may be equipped with a through hole through which a control rod and/or a control cable of the tissue clamping device pass.

In some embodiments, the second pipe body may have a mesh woven structure.

In some embodiments, a material layer of polyether block polyamide may be disposed on an outer surface of the outer pipe.

According to another aspect of the present disclosure, a tissue repair device is provided. The tissue repair device may include the delivery pipe of the tissue clamping device mentioned above.

In some embodiments, the tissue repair device may include a first control handle, the first control handle may include a delivery pipe control mechanism, the delivery pipe control mechanism may be configured to control the first pipe body of the delivery pipe to bend.

In some embodiments, the tissue repair device may further include a guide pipe, the guide pipe may include a bend structure and at least two second traction filaments, the bend structure may include a third pipe body and a fourth pipe body, one end of the third pipe body may be connected to the fourth pipe body. The at least two second traction filaments may pass through the third pipe body and the fourth pipe body along length directions of the third pipe body and the fourth pipe body, one end of each of the at least two second traction filaments may be fixed to another end of the third pipe body. The at least two second traction filaments may be able to be tensioned, respectively, to control the third pipe body to bend to different directions.

In some embodiments, the at least two second traction filaments may include two second traction filaments located in a radial direction of the bend structure at both ends of the bend structure, respectively. When one of the two second traction filaments is tensioned, another of the two second traction filaments may be relaxed.

In some embodiments, the tissue repair device may include a second control handle, the second control handle may include a housing and a guide pipe control assembly disposed within the housing, the guide pipe control assembly may be configured to control the at least two second traction filaments of the guide pipe to be tensioned respectively, to control the third pipe body of the bend structure of the guide pipe to bend to different directions.

In some embodiments, a count of the at least two second traction filaments may be two. One end of the fourth pipe body of the bend structure of the guide pipe away from the third pipe body may be fixed to the housing. The guide pipe control assembly may include a threaded sleeve, a first traction component, and a second traction component, one end of the two second traction filaments away from a fixing ring may be connected to the first traction component and the second traction component, respectively, the threaded sleeve may be equipped with a first thread and a second thread, a rotation direction of the first thread may be opposite to a rotation direction of the second thread, the first traction component may be connected to the threaded sleeve through coordination with the first thread, the second traction component may be connected to the threaded sleeve through coordination with the second thread. When the threaded sleeve is rotated, the first traction component and the second traction component may be able to move in opposite directions along a length direction of the threaded sleeve to make one of the two second traction filaments be tensioned and another of the two second traction filaments be relaxed.

In some embodiments, the first thread and the second thread may be internal threads located on an inner wall of the threaded sleeve, the first traction component and the second traction component may be disposed in the threaded sleeve. The first traction component may include a first accommodation groove, and the second traction component may include a second accommodating groove, the first accommodation groove and the second accommodation groove may be disposed oppositely, and a portion of the guide pipe may be able to be accommodated in the first accommodation groove and the second accommodation groove.

According to another aspect of the present disclosure, a guide pipe is provided. The guide pipe may include a bend structure and at least two second traction filaments, the bend structure may include a third pipe body and a fourth pipe body, one end of the third pipe body may be connected to the fourth pipe body. The at least two second traction filaments may pass through the third pipe body and the fourth pipe body along length directions of the third pipe body and the fourth pipe body, one end of each of the at least two second traction filaments may be fixed to another end of the third pipe body. The at least two second traction filaments may be able to be tensioned, respectively, to control the third pipe body to bend to different directions.

In some embodiments, the bend structure may further include a fixing ring, the fixing ring may be connected to the another end of the third pipe body, the one end of each of the plurality of second traction filaments may be fixed to the fixing ring.

In some embodiments, the guide pipe may further include an outer layer structure and an inner layer structure, the outer layer structure, the bend structure, and the inner layer structure may be disposed along a radial direction of the guide pipe from outside to inside.

In some embodiments, a mounting hole may be disposed on the fixing ring, the mounting hole may be configured to fix the inner layer structure and/or the outer layer structure.

In some embodiments, the third pipe body may include a first sub-pipe body formed by spiral winding of a first wire strip and a second sub-pipe body woven from a second wire strip, the second sub-pipe body may be sleeved outside the first sub-tube body.

In some embodiments, the fourth pipe body may be woven from the second wire strip, the second sub-pipe body and the fourth pipe body may be an integral structure.

In some embodiments, the first wire strip may include a first sub-wire strip and a second sub-wire strip, the first sub-wire strip and the second sub-wire strip may be alternate and spiral winding, a cross-section of the first sub-wire strip may be a rectangular shape, a rectangular shape having a chamfer, or an irregular shape having parallel edges, a cross-section of the second sub-wire strip may have an arc contour.

In some embodiments, the third pipe body may be equipped with a plurality of second notches along a length direction of the third pipe body, opening directions of two adjacent second notches may be different.

In some embodiments, the third pipe body may be integrally formed by cutting a metal tube, and the fourth pipe body may be woven from a third wire strip, a connection ring may be disposed between the third pipe body and the fourth pipe body.

According to another aspect of the present disclosure, a tissue repair device is provided. The tissue repair device may include the guide pipe mentioned above.

In some embodiments, the tissue repair device may include a second control handle. The second control handle may include a housing and a guide pipe control assembly disposed within the housing. The guide pipe control assembly may be configured to control the at least two second traction filaments of the guide pipe to be tensioned respectively, to control the third pipe body of the bend structure of the guide pipe to bend to different directions.

In some embodiments, a count of the at least two second traction filaments may be two. One end of the fourth pipe body of the bend structure of the guide pipe away from the third pipe body may be fixed to the housing. The guide pipe control assembly may include a threaded sleeve, a first traction component, and a second traction component; one end of the two second traction filaments away from the fixing ring may be connected to the first traction component and the second traction component, respectively; the threaded sleeve may be equipped with a first thread and a second thread, a rotation direction of the first thread may be opposite to a rotation direction of the second thread, the first traction component may be connected to the threaded sleeve through coordination with the first thread, the second traction component may be connected to the threaded sleeve through coordination with the second thread. When the threaded sleeve is rotated, the first traction component and the second traction component may be able to move in opposite directions along a length direction of the threaded sleeve to make one of the two second traction filaments be tensioned and another of the two second traction filaments be relaxed.

In some embodiments, the first thread and the second thread may be internal threads located on an inner wall of the threaded sleeve. The first traction component and the second traction component may be disposed in the threaded sleeve. The first traction component may include a first accommodation groove, the second traction component may include a second accommodating groove, the first accommodation groove and the second accommodation groove may be disposed oppositely, and a portion of the guiding tube may be able to be accommodated in the first accommodation groove and the second accommodation groove.

In some embodiments, the second control handle may further include a bending indicator assembly. The bending indicator assembly may include an external thread disposed on an outer wall of the threaded sleeve, a position indicating mechanism connected to the threaded sleeve in coordination with the external thread, and an indication identifier disposed on the housing. The position indicating mechanism may be able to move along the length direction of the threaded sleeve when the threaded sleeve rotates.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure is further described in terms of exemplary embodiments. These exemplary embodiments are described in detail with reference to the drawings. It should be noted that the drawings are not to scale. These embodiments are non-limiting exemplary embodiments, in which like reference numerals represent similar structures throughout the several views of the drawings, and wherein:

FIG. 1 is a structural schematic diagram illustrating a delivery pipe of a tissue clamping device according to some embodiments of the present disclosure;

FIG. 2 is an explosion schematic diagram illustrating a delivery pipe of a tissue clamping device according to some embodiments of the present disclosure;

FIG. 3 is a partial enlarged view illustrating the connection between a blocking member and a spring tube shown in FIG. 2 according to some embodiments of the present disclosure;

FIG. 4 is a structural schematic diagram illustrating a first pipe body according to some embodiments of the present disclosure;

FIG. 5 is a structural schematic diagram illustrating a first pipe body from another perspective according to some embodiment of the present disclosure;

FIG. 6 is a structural schematic diagram illustrating a second pipe body according to some embodiment of the present disclosure;

FIG. 7 is a structural schematic diagram illustrating a tissue repair device according to some embodiments of the present disclosure;

FIG. 8 is a structural schematic diagram illustrating a delivery connection member and a tissue clamping device according to some embodiments of the present disclosure;

FIG. 9 is a structural schematic diagram illustrating a delivery connection member according to some embodiments of the present disclosure;

FIG. 10 is a structural schematic diagram illustrating an open state of an outer clamp arm of a tissue clamping device according to some embodiments of the present disclosure;

FIG. 11 is a decomposition structure diagram illustrating a delivery pipe control mechanism according to some embodiments of the present disclosure;

FIG. 12 is a partial sectional diagram illustrating an outer clamp arm control mechanism according to some embodiments of the present disclosure;

FIG. 13 is a structural schematic diagram illustrating a sleeve according to some embodiments of the present disclosure;

FIG. 14 is a decomposition structure diagram illustrating a sliding part and a protective cover according to some embodiments of the present disclosure;

FIG. 15 is a partial sectional diagram illustrating an inner clamp arm control mechanism according to some embodiments of the present disclosure;

FIG. 16 is a structural schematic diagram illustrating a housing according to some embodiments of the present disclosure;

FIG. 17 is a structural schematic diagram illustrating a second control part according to some embodiments of the present disclosure;

FIG. 18 is a structural schematic diagram illustrating a second control part and a locking mechanism at a first perspective according to some embodiments of the present disclosure;

FIG. 19 is a structural schematic diagram illustrating a second control part and a locking mechanism at a second perspective according to some embodiments of the present disclosure;

FIG. 20 is a structural schematic diagram illustrating a guide pipe according to some embodiments of the present disclosure;

FIG. 21 is a schematic diagram illustrating the connection among a fixing ring of a guide pipe, a second traction filament, and a third pipe body according to some embodiments of the present disclosure;

FIG. 22 is a structural schematic diagram illustrating a third pipe body of a guide pipe according to another embodiment of the present disclosure;

FIG. 23 is a structural schematic diagram illustrating a fourth pipe body of a guide pipe according to another embodiment of the present disclosure;

FIG. 24 is a structural schematic diagram illustrating a first sub-pipe body of a third pipe body according to some embodiments of the present disclosure;

FIG. 25 is a structural schematic diagram illustrating a guide pipe according to another embodiment of the present disclosure;

FIG. 26 is a schematic structural diagram illustrating a third pipe body of a guide pipe according to another embodiment of the present disclosure;

FIG. 27 is a structural diagram illustrating a fourth pipe body of a guide pipe according to another embodiment of the present disclosure;

FIG. 28 is a structural schematic diagram illustrating a tissue repair device according to some embodiments of the present disclosure;

FIG. 29 is a structural schematic diagram illustrating a guide pipe control assembly of a second control handle of a tissue repair device according to some embodiments of the present disclosure;

FIG. 30 is a structural schematic diagram illustrating a first traction component and a second traction component of a second control handle of a tissue repair device according to some embodiments of the present disclosure; and

FIG. 31 is a structural schematic diagram illustrating a bending indicator assembly of a second control handle of a tissue repair device according to some embodiments of the present disclosure.

Reference numerals and corresponding structures are described as follows: 10-tissue repair device; 100-delivery pipe; 110-outer pipe; 111-first pipe body; 111-1-first notch; 111-2-first fixing part; 111-3-second fixing part; 112-second pipe body; 120-inner core; 121-groove; 122-through hole; 130-traction mechanism; 131-first traction filament; 132-spring tube; 133-blocking member; 140-delivery connection member; 142-main body; 144-first connection piece; 146-second connection piece; 148-fixed supporting rod; 150-connection member; 200-tissue clamping device; 210-inner clamp arm; 211-first inner clamp arm; 213-second inner clamp arm; 215-barb; 220-outer clamp arm; 221-first outer clamp arm; 223-second outer clamp arm; 230-first fixing member; 240-supporting part; 250-second fixing member; 260-outer clamping plate; 261-first outer clamping plate; 263-second outer clamping plate; 300-first control handle; 400-outer clamp arm control mechanism; 410-sleeve; 412-first sliding groove; 420-first control part; 421-connection groove; 429-connection block; 430-sliding part; 440-control rod; 460-fixing block; 470-protective cover; 500-inner clamp arm control mechanism; 510-housing; 511-second sliding groove; 520-second control part; 521-duct; 523-end cover; 530-locking mechanism; 531-elastic member; 533-locking button; 535-locking block; 537-tooth-shaped connecting part; 600-delivery pipe control mechanism; 610-screw; 620-rotating part; 630-traction part; 635-threaded traction block; 640-bending indication device; 1000-guide pipe; 1100-bend structure; 1200-second traction filament; 1110-third pipe body; 1120-fourth pipe body; 1130-fixing ring; 1140-connection ring; 1111-first wire strip; 1112-second wire strip; 1111-1-first sub-wire strip; 1111-2-second sub-wire strip; 1113-second notch; 1114-third wire strip; 1131-mounting hole; 2000-second control handle; 2100-housing; 2200-guide pipe control assembly; 2300-bending indicator assembly; 2400-runner; 2500-mounting pipe; 2210-threaded sleeve; 2220-first traction component; 2230-second traction component; 2221-first accommodation groove; 2222-first connecting struct; 2231-second accommodation groove; 2232-second connecting struct; 2310-external thread; 2320-position indicator mechanism; 2330-indication mark.

DETAILED DESCRIPTION

The following description is presented to enable any person skilled in the art to make and use the present disclosure and is provided in the context of a particular application and its requirements. Various modifications to the disclosed embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the present disclosure. Thus, the present disclosure is not limited to the embodiments shown but is to be accorded the widest scope consistent with the claims.

On the contrary, the present disclosure covers any alternatives, modifications, equivalent methods and solutions defined by the claims in the spirit and scope. Further, in order to enable those skilled in the art to have a better understanding of the present disclosure, some specific details are described in detail in the detailed description below. Those skilled in the art can fully understand the present disclosure without the description of these details.

The terminology used herein is to describe particular example embodiments only and is not intended to be limiting. As used herein, the singular forms “a, ” “an, ” and “the” may be intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms “comprises, ” “comprising, ” “includes, ” and/or “including” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

These and other features, and characteristics of the present disclosure, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, may become more apparent upon consideration of the following description with reference to the accompanying drawing (s) , all of which form a part of this specification. It is to be expressly understood, however, that the drawing (s) is for the purpose of illustration and description only and are not intended to limit the scope of the present disclosure. It is understood that the drawings are not to scale.

The present disclosure relates to a delivery pipe of a tissue clamping device and a tissue repair device thereof. The tissue repair device may be configured to repair a heart valve (such as a mitral valve, a tricuspid valve, etc. ) or other valves. The tissue repair device may include a tissue clamping device. The tissue clamping device may be configured to clamp a valve to repair it. The delivery pipe may be configured to fix and transport the tissue clamping device. In some embodiments, the tissue clamping device may reach a predetermined position through a specific path. For example, the tissue clamping device may be transported to the mitral valve via the femoral vein, inferior vena cava, right atrium, and left atrium to repair the mitral valve.

In some embodiments, a delivery pipe of a tissue clamping device disclosed in the present disclosure may also be applied to other types of interventional medical equipment. For example, the delivery pipe may also be applied to cardiac interventional equipment, nervous system interventional equipment, vascular interventional equipment, artificial insemination equipment, etc. The interventional medical equipment including the delivery pipe may be applied to valve repair surgery, heart stent surgery, puncture surgery, drug perfusion surgery, vascular embolization surgery, artificial insemination surgery, etc. In some alternative embodiments, the delivery pipe may also be applied to other medical equipment or other technical fields (such as testing instruments) , etc.

FIG. 1 is a structural schematic diagram illustrating a delivery pipe of a tissue clamping device according to some embodiments of the present disclosure. FIG. 2 is an explosion schematic diagram illustrating a delivery pipe of a tissue clamping device according to some embodiments of the present disclosure. FIG. 3 is a partial enlarged view illustrating the connection between a blocking member and a spring tube shown in FIG. 2 according to some embodiments of the present disclosure. FIG. 4 is a structural schematic diagram illustrating a first pipe body according to some embodiments of the present disclosure. FIG. 5 is a structural schematic diagram illustrating a first pipe body from another perspective according to some embodiment of the present disclosure. FIG. 6 is a structural schematic diagram illustrating a second pipe body according to some embodiment of the present disclosure. The delivery pipe of the tissue clamping device involved in the embodiments of the present disclosure may be described in detail with reference to FIGs. 1-6. It should be noted that the following embodiments are merely intended to explain the present disclosure, and not intended to limit the scope of the present disclosure.

As shown in FIGs. 1-6, a delivery pipe 100 may include an outer pipe 110, an inner core 120, and a traction mechanism 130. The outer pipe 110 may be sleeved outside the inner core 120. In some embodiments, the delivery pipe 100 may further include a delivery connection member 140. The delivery pipe 100 may be detachably connected to the tissue clamping device through the delivery connection member 140. In some embodiments, the outer pipe 110 may also include a first pipe body 111 and a second pipe body 112. One end of the first pipe body 111 may be connected to the tissue clamping device, another end of the first pipe body 111 may be connected to the second pipe body 112. Specifically, the first pipe body 111 may be disposed at a front end of the delivery pipe 100 (e.g., one end away from the tissue clamping device) , and the first pipe body 111 and the second pipe body 112 may be connected end to end. In some embodiments, as shown in FIGs. 2-3, another end of the first pipe body 111 may be connected to the second pipe body 112 through a connection member 150. In some alternative embodiments, another end of the first pipe body 111 may be directly connected to the second pipe body 112. In some embodiments, both ends of the first pipe body 111 may be provided with a first fixing part 111-2 and a second fixing part 111-3, respectively. The first fixing part 111-2 and the second fixing part 111-3 may be integrally formed with the pipe body 111. The first pipe body 111 may be connected to the delivery connection member 140 by the first fixing part 111-2 (e.g., clamping connection) , and the first pipe body 111 may be connected to the connection member 150 by the second fixing part 111-3 (e.g., clamping connection) . In some embodiments, the second pipe body 112 away from one end of the first pipe body 111 may be connected to a first control handle. In some embodiments, the inner core 120 may be equipped with one or more through holes through which a control rod and/or a control cable of the tissue clamping device pass. In some embodiments, the inner core 120 may be made of an elastic material (such as nylon, silica gel, thermal polyether block polyamide (PEBAX) , polytetrafluoroethylene (PTFE) material) , thus the inner core 120 may have certain elasticity, so that the outer pipe 110 may drive the inner core 120 to bend when the outer pipe 110 is bent.

In some embodiments, a traction mechanism 130 may be configured to control the first pipe body 111 to bend. In some embodiments, the traction mechanism 130 may include a first traction filament 131. One end of the first traction filament 131 may be fixedly connected to one end (e.g., the front end) of the first pipe body 111. For example, one end of the first traction filament 131 may be fixedly connected to the first fixing part 111-2 or other part of the first pipe body 111 by welding connection, bonding connection, clamping connection, etc. In some alternative embodiments, one end of the first traction filament 131 may be fixedly connected to the inner core 120. The other end of the first traction filament 131 may be connected to the delivery pipe control mechanism, and the delivery pipe control mechanism may control the first pipe body 111 to bend by tensioning or relaxing the first traction filament 131. In some embodiments, one side of the inner core 120 may be equipped with a groove 121 in a length direction of the inner core 120, and the first traction filament 131 may be disposed in the groove 121. The groove 121 may restrict the position of the first traction filament 131 to prevent the first traction filament 131 from being inclined or winding between the outer pipe 110 and the inner core 120, thereby ensuring that the first traction filament 131 can accurately control the bending direction and degree of the first pipe body 111. In some embodiments, the traction mechanism 130 may further include a spring tube 132, the spring tube 132 may be sleeved on a portion of the first traction filament 131 corresponding to the second pipe body 112. When the first traction filament 131 is tensioned by the delivery pipe control mechanism, the first traction filament 131 may drive the first pipe body 111 to bend. Because the spring tube 132 is sleeved on a portion of the first traction filament 131 corresponding to the second pipe body 112, the spring tube 132 may generate a stress that hinders the second pipe body 112 to bend, thereby reducing the influence of the first traction filament 131 on the second pipe body 112, and thus the first traction filament 131 may be primarily configured to control the first pipe body 111 to bend. In some embodiments, the spring tube 132 with different elastic coefficients may be provided in accordance with different bending requirements of the first pipe body 111 and the second pipe body 112. In some embodiments, the first traction filament may include a steel wire rope, a nanofilament, a glass rope, etc., and the present disclosure may not limit it herein.

In some embodiments, one end of the spring tube 132 may be fixedly connected to the outer pipe 110 (the second pipe body 112, or a connection between the first pipe body 111 and the second tube 112) or the inner core 120 directly, a fixed connection between the outer pipe110 or the inner core 120 and the spring tube 132 may restrict and block the spring tube 132. In some embodiments, the traction mechanism 130 may further include a blocking member 133. The blocking member 133 may be sleeved on the first traction filament 131 and fixed at the connection of the first pipe body 111 and the second pipe body 112 to block the spring tube 132. In some embodiments, the blocking member 133 may have a cylindrical structure, and the cylindrical structure may have a through hole (not shown in FIG. 3) along a length direction. The first traction filament 131 may pass through the through hole and move in the through hole of the blocking member 133. One end of the spring tube 132 may abut or be fixedly connected to the blocking member 133, and the diameter of the spring tube 132 may be larger than the through hole of the blocking member 133, thus the spring tube 132 may not move relative to the blocking member 133. In some embodiments, the blocking member 133 may restrict the first traction filament 131 to prevent the first traction filament 131 from being offset relative to the groove 121. It should be noted that the blocking member 133 may not be limited to the cylindrical structure shown in FIG. 2 and FIG. 3, structures that may block the movement of the spring tube 132 along the length direction of the inner core may be regarded as the blocking member 133 in the embodiments of the present disclosure.

In some embodiments, the connection of the first pipe body 111 and the second pipe body 112 may be equipped with the connection member 150, both ends of the connection member 150 may be connected to the second fixing part 111-3 of the first pipe body 111 and the end part of the second pipe body 112 (such as clamping connection, abutting connection, fixedly connection, etc. ) , respectively. For example, the outer surface of the outer pipe 110 may be provided with a polymer layer (such as a thermochemical polyether block polyamide (PEBAX) layer) . In the preparation process, the polymer layer of the outer surface of the first pipe body 111, the connection member 150, and the second pipe body 112 may be in a molten state at a relatively high temperature. The first pipe body 111, the connection member 150, and the second pipe body 112 may be fixedly connected after cooling. In some embodiments, the blocking member 133 may be fixedly connected to the connection member 150 (such as welding connection, bonding connection, etc. ) . In some embodiments, the blocking member 133 may be integrally formed with the connection member 150. In some alternative embodiments, the blocking member 133 may be fixedly connected to the inner core 120.

In some embodiments, one side of the first pipe body 111 may be equipped with a plurality of first notches 111-1 along a length direction of the first pipe body 111, the first pipe body 111 may be able to bend to an opening direction of the plurality of first notches 111-1. With the arrangement of the plurality of first notches 111-1, the first pipe body 111 may be easier to bend, and the first pipe body 111 may be bent in a particular direction. In the present embodiment, the plurality of first notches 111-1 may be arranged on one side of the first pipe body 111, so that the first pipe body 111 may be able to bend to an opening direction of the plurality of first notches 111-1. Specifically, one side of the plurality of first notches 111-1 in the opening direction may be the same as the side where the groove 121 on the inner core 120 is arranged. In other embodiments, the plurality of first notches 111-1 may be spaced apart from different sides of the first pipe body 111. In this case, the different sides corresponding to the inner core 120 may be equipped with a groove, and the traction mechanism 130 may include a plurality of corresponding first traction filaments, thus different first traction filaments may control the first pipe body 111 to bend in different directions. In some embodiments, the first pipe body 111 may be integrally formed by cutting a stainless steel (e.g., 316 stainless steel) or a shape memory alloy (such as a nickel titanium alloy) tube.

In some embodiments, the opening sizes of the plurality of first notches 111-1 may be same, and each part of the first pipe body 111 may have the same bending ability. The opening sizes of the first notches may refer to the distance between the two sides of the opening end of the first notches. In some embodiments, the opening sizes of the plurality of first notches 111-1 may be unidentical, that is, the opening sizes of some first notches 111-1 may be the same, while the opening sizes of other first notches 111-1 may be different, or the opening sizes of any one of the first notches 111-1 may be different from that of the others, thus different parts of the first pipe body 111 may have different bending abilities. For example, when the force of the first traction filament 131 is constant, the larger the opening sizes of the first notches 111-1, the larger the bending degree of the first pipe body 111; the smaller the opening sizes of the first gap 111-1, the smaller the bending degree of the first pipe body 111. In some embodiments, an opening size of the first notches 111-1 at one end of the first pipe body 111 close to the tissue clamping device may be less than an opening size of the first notches 111-1 close to another end (one end connected with the second pipe body 112) of the first pipe body 111. When the first traction filament 131 is tensioned, the first traction filament 131 may drive the first pipe body 111 to bend. Because the opening size of the first notches 111-1 at one end of the first pipe body 111 close to the tissue clamping device is relatively small, the bending degree of the first pipe body 111 at this end may be relatively small, and the bending degree of the first pipe body at the other end may be relatively large. The settings mentioned above may facilitate the tissue clamping device to align with a target area (e.g., a heart valve to be repaired) .

In some embodiments, the second pipe body 112 may have a mesh woven structure. On the one hand, the mesh woven structure may have a good torque control performance. When a first control handle is rotated, the second pipe body 112 may transmit the torque of the first control handle to rotate the first pipe body 111. On the other hand, the mesh woven structure may have better exploded pressure performance and anti-bending ability. When the delivery pipe 100 enters the human tissue (such as blood vessels, atrial wall, etc. ) , the second pipe body 112 having the mesh woven structure may be under the extrusion of the human tissue, and the second pipe body 112 may keep the normal shape. When the first traction filament 131 is tensioned, the first traction filament 131 may drive the outer pipe 110 (the first pipe body 111 and the second pipe body 112) and the inner core 120 to bend, the second pipe body 112 having higher anti-bending ability may enable the first traction filament 131 to have a small bending effect on the second pipe body 112, thereby making the first traction filament 131 to better control the first pipe body 111 to bend.

In some embodiments, a layer of thermoplastic material may be disposed on an outer surface of the outer pipe 110. For example, the thermoplastic material may include polyether block polyamide (PEPAX) , polyurethane, polyamide, polyamide, polyethylene, polypropylene, polytetrafluoroethylene, or any combination thereof. Preferably, the outer surface of the outer tube 110 may be provided with a layer of thermally condensed polyether block polyamide, which may effectively reduce the contact of blood to the tube. In addition, the thermoplastic material may have high stability, fatigue, good resilience and elastic recovery performance at low temperatures, which may improve the accuracy of the delivery pipe 100 in the bending process. In some embodiments, to further reduce the friction between the outer pipe 110 and the body, the outer surface of the outer pipe 110 may be provided with a hydrophilic coating. In some embodiments, the material of the hydrophilic coating may include polyacrylic acid, silica, silicone, siloxane, urethane, or the like, or any combination thereof.

The delivery pipe 100 of a tissue clamping device described in the present disclosure may have functions of delivering tissue clamping device and bending, making the corresponding medical equipment (such as a tissue repair device) more convenient in operation. It should be noted that the description of the delivery pipe 100 may be merely for illustration, and is not intended to limit the present disclosure. It may be understood that for those skilled in the art, after understanding the principle of the delivery pipe 100 in the present disclosure, it may be possible to make various modifications and changes in the form and details without departing from the principles. For example, the outer pipe 110 may not be limited to the first pipe body 111 and the second pipe body 112 described above. In some embodiments, the outer pipe 110 may also include other pipe bodies, or the like, to accommodate the surgery of the human body by controlling the bending of the first pipe body 111 and the other pipe bodies.

FIG. 7 is a structural schematic diagram illustrating a tissue repair device according to some embodiments of the present disclosure. FIG. 8 is a structural schematic diagram illustrating a delivery connection member and a tissue clamping device according to some embodiments of the present disclosure. FIG. 9 is a structural schematic diagram illustrating a delivery connection member according to some embodiments of the present disclosure. FIG. 10 is a structural schematic diagram illustrating an open state of an outer clamp arm of a tissue clamping device according to some embodiments of the present disclosure. As shown in FIGs. 7-10, a tissue repair device 10 may include the tissue clamping device 200 and a first control handle 300. The tissue clamping device 200 may include an outer clamp arm 220 and an inner clamp arm 210. The first control handle 300 may include an outer clamp arm control mechanism 400 and an inner clamp arm control mechanism 500. The outer clamp arm control mechanism 400 may be configured to control the opening and closing of the outer clamp arm 220 of the tissue clamping device 200. The inner clamp arm control mechanism 500 may be configured to control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220. A valve (such as a mitral valve) may be clamped between the outer clamp arm 220 and the inner clamp arm 210 by controlling the opening and closing of the outer clamp arm 220 and the inner clamp arm 210 via the first control handle 300.

In some embodiments, the tissue repair device 10 may include the delivery pipe 100 of the tissue clamping device 200. The tissue clamping device 200 may be connected to the first control handle 300 via the delivery pipe 100. In some embodiments, the first control handle 300 may deliver the tissue clamping device 200 to the valve to be repaired via the delivery pipe 100. For example, the first control handle 300 may deliver the tissue clamping device 200 to the mitral valve via the femoral vein, the inferior vena cava, the right atrium, and the left atrium through the delivery pipe 100. In some embodiments, the first control handle 300 may include a delivery pipe control mechanism 600, the delivery pipe control mechanism 600 may be configured to control the first pipe body 111 of the delivery pipe 100 to bend. More descriptions about the delivery pipe 100 and the first pipe body 111 may be found in other embodiments (such as the embodiments shown in FIGs. 1-5) and related description thereof. More descriptions about the delivery pipe control mechanism 600 may be found in other embodiments of the present disclosure (such as the embodiments shown in FIG. 11) and related description thereof.

In some embodiments, the tissue repair device 10 may include a supporting pipe (not shown in figures) . The supporting pipe may be sent into the body first during repairing the valve. For example, during repairing the mitral valve, the supporting pipe may be delivered to the left atrium via the femoral vein, inferior vena cava, or right atrium. The first control handle 300 may be configured to deliver the tissue clamping device 200 to the valve to be repaired (such as the mitral valve) via the supporting pipe. Specifically, the first control handle 300 may deliver the tissue clamping device 200 via the delivery pipe 100 to make the tissue clamping device 200 and the first pipe body 111 protrude from the front end of the supporting pipe, and the first control handle 300 (such as the delivery pipe control mechanism 600) may control the first pipe body 111 to bend, thus the tissue clamping device 200 may face the valve to be repaired. If the tissue clamping device 200 cannot reach the valve to be repaired, the first control handle 300 may control the first pipe body 111 to further protrude from the supporting pipe, and the bending degree of the supporting pipe and/or the first pipe body 111 may be adjusted during the process of controlling the first pipe body 111 to protrude from the supporting pipe, thus the tissue clamping device 200 may move toward the valve to be repaired. In some embodiments, an opening size of the plurality of first notches 111-1 at the end of the first pipe body 111 close to the tissue clamping device 200 may be less than an opening size of the plurality of first notches 111-1 close to another end of the first pipe body 111, thus the front end of the first pipe body 111 protruding from the supporting pipe may have a smaller bending degree than the rear end, thereby the delivery of the tissue clamping device 200 to the valve to be repaired may be better controlled.

In some embodiments, as shown in FIGs. 8-10, the tissue clamping device 200 may include the inner clamp arm 210, the outer clamp arm 220, a first fixing member 230, a supporting part 240, a second fixing member 250, and an outer clamping plate 260. The inner clamp arm 210 may include a first inner clamp arm 211 and a second inner clamp arm 213. The outer clamp arm 220 may include a first outer clamp arm 221 and a second outer clamp arm 223. The outer clamping plate 260 may include a first outer clamping plate 261 and a second outer clamping plate 263. One side of the supporting part 240 may be bendably connected to the first outer clamp arm 221 and the first outer clamping plate 261 in sequence. The other side of the supporting part 240 may be bendably connected to the second outer clamp arm 223 and the second outer clamping plate 263 in sequence. The first outer clamp arm 221 and the second outer clamp arm 223 may be bent toward the supporting part 240 and closed relative to each other. The first outer clamp arm 221 and the second outer clamp arm 223 may be bent away from the supporting part 240 and opened relative to each other. The tissue clamping device 200 shown in FIG. 8 is in a state where the first outer clamp arm 221 and the second outer clamp arm 223 are closed relative to each other. The tissue clamping device 200 shown in FIG. 10 is in a state where the first outer clamp arm 221 and the second outer clamp arm 223 are opened relative to each other, and an opening angle they formed (also referred to as an opening angle of the outer clamp arm) is 180°. As used herein, the opening angle refers to an angle between the two outer clamp arms opening to each other. The opening angle of the outer clamp arm may be any angle, such as 10°, 40°, 90°, 120°, 180°, 270°, 350°, 360°. In some embodiments, the outer clamp arm 220, the supporting part 240, and the outer clamping plate 260 may be in an integrally formed structure. For example, the outer clamp arm 220, the supporting part 240 and the outer clamping plate 260 may be in an integrally formed structure made by cutting and heat-treating a shape memory alloy tube. In some embodiments, as shown in FIG. 8, one end of the supporting part 240 (an upper end shown in the figure) may be connected (e.g., fixedly connected) to the second fixing member 250, and one end (a lower end shown in the figure) of the first outer plate 261 and one end (a lower end shown in the figure) of the second outer clamping plate 263 may be respectively connected (e.g., fixedly connected) to the first fixing member 230. With this arrangement, when moving relative to the second fixing member 250, the first fixing member 230 may move relative to the supporting part 240. When the first fixing member 230 moves away from the supporting part 240, the first outer clamping plate 261 and the second outer clamping plate 263 may be driven by the first fixing member 230, and thus respectively pull the first outer clamp arm 221 and the second outer clamp arm 223 to make them open relatively. In FIGs. 8-10, the outer clamp arm control mechanism 400 may control the opening and closing of the outer clamp arm 220 of the tissue clamping device 200 via a control rod 440. Specifically, one end (a lower end as shown in FIG. 8) of the control rod 440 may have a threaded structure. The control rod 440 may be detachably connected to the first fixing member 230 by the threaded structure. The outer clamp arm control mechanism 400 may control the movement of the first fixing member 230 relative to the second fixing member 250 by pushing and pulling the control rod 440, thereby controlling the opening and closing of the outer clamp arm 220 of the tissue clamping device 200.

In some embodiments, the first inner clamp arm 211 may be disposed on the first outer clamp arm 221, and the second inner clamp arm 213 may be disposed on the second outer clamp arm 223. The first inner clamp arm 211 and the second inner clamp arm 213 may be opened and closed relative to the first outer clamp arm 221 and the second outer clamp arm 223, respectively, which enables the tissue to be clamped between the first inner clamp arm 211 and the first outer clamp arm 221 and to be clamped between the second inner clamp arm 213 and the second outer clamp arm 223. In some embodiments, the inner clamp arm 210 (i.e., the first inner clamp arm 211 and the second inner clamp arm 213) may be barbed clips. For example, each of movable ends of the inner clamp arm 210 may be disposed with barbs 215. In some embodiments, the inner clamp arm 210 and the outer clamp arm 220 may be connected by bending parts (such as an S-shaped bending structure) . The bending parts may have a rebound force, so that the inner clamp arm 210 can closely contact the outer clamp arm 220 in a natural state. In some embodiments, the inner clamp arm control mechanism 500 may control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220 by a control cable (not shown in the figures) . For example, the control cable may be connected to the movable ends of the inner clamp arm 210. When the inner clamp arm control mechanism 500 pulls the control cable, the inner clamp arm 210 may be opened relative to the outer clamp arm 220 under a pulling force of the control cable. When the control cable is relaxed, the inner clamp arm 210 may be closed to the outer clamp arm 220 under the rebound force of the bending parts. In some embodiments, the control cable may include steel wire, nanowire or glass rope, etc., which is not limited in the present disclosure.

In some embodiments, the delivery pipe 100 may be detachably connected to the tissue clamping device 200 by the delivery connection member 140. For example, a fixing part 111-2 of the first pipe body 111 may be detachably connected to the tissue clamping device 200 via the delivery connection member 140 (e.g., clamping connection, threaded connection, etc. ) . The delivery connection member 140 may be equipped with through holes, through which the control rod 440 and the control cable may pass respectively. In FIGs. 8 and 9, the delivery connection member 140 may include a main body 142, a first connection piece 144, and a second connection piece 146. There may be a rebound force at the connections between the first connection piece 144 and the main body 142 and between the second connection piece 146 and the main body 142, which may make the first connection piece 144 and the second connection piece 146 automatically open in a natural state. Fixed supporting rods 148 may be disposed on the middle of the first connection piece 144 and the second connection piece 146 and perpendicular to the first connection piece 144 and the second connection piece 146, respectively. Suspended ends of the fixed supporting rods 148 may be provided with through holes, through which the control rod 440 may pass. When the delivery connection member 140 is connected to the second fixing member 250 of the tissue clamping device 200, the first connection piece 144 and the second connection piece 146 may be relatively closed and engaged with protrusions of the second fixing member 250, respectively. At this time, the control rod 440 may pass through the through holes of the fixed supporting rods 148 connected to the first connection piece 144 and the second connection piece 146, and restrict the opening of the first connection piece 144 and the second connection piece 146. When the delivery connection member 140 needs to be separated from the tissue clamping device 200, the control rod 440 may be first disconnected from the tissue clamping device 200 (such as the first fixing member 230) , and then drawn out until separated from the through holes of the fixed supporting rods 148 connected to the first connection piece 144 and the second connection piece 146. Then, the first connection piece 144 and the second connection piece 146 may be disengaged from the protrusions of the second fixing member 250 and automatically opened. In some embodiments, the delivery connection member 140 may be in an integrally formed structure made by cutting and heat-treating a shape memory alloy tube. In some embodiments, the tissue clamping device 200 may have other alternative structures.

In some embodiments, the first control handle 300 may include the outer clamp arm control mechanism 400 and the inner clamp arm control mechanism 500. The outer clamp arm control mechanism 400 may be configured to control the movement of the outer clamp arm 220 of the tissue clamping device 200. The inner clamp arm control mechanism 500 may be configured to control the movement of the inner clamp arm 210 of the tissue clamping device 200. In some embodiments, the first control handle 300 may include the delivery pipe control mechanism 600, and the delivery pipe control mechanism 600 may control the first pipe body 111 to bend.

FIG. 11 is a decomposition structure diagram illustrating a delivery pipe control mechanism according to some embodiments of the present disclosure. In some embodiments, as shown in FIG. 11, the delivery pipe control mechanism 600 may include a screw 610, a rotating part 620, and a traction part 630. The screw 610 and the traction part 630 may be threadedly connected. The rotating part 620 may drive the screw 610 to rotate, thereby driving the traction part 630 to move. The traction part 630 may control the first pipe body 111 to bend when moving. In some embodiments, the traction part 630 may include the first traction filament 131 and a threaded traction block 635. One end (such as a rear end) of the first traction filament 131 may be connected to the threaded traction block 635, and the other end (such as a front end) of the first traction filament 131 may be fixedly connected to the front end of the first pipe body 111. An internal thread may be disposed in the screw 610, and the threaded traction block 635 may be movably disposed in the screw 610 and cooperate with the internal thread of the screw 610. When the rotating part 620 drives the screw 610 to rotate, the screw 610 may drive the threaded traction block 635 to move, along the length direction, in the screw 610, so as to realize the traction or loosening of the first traction filament 131, thereby controlling the bending of the first pipe body 111. Specifically, the traction of the first pipe body 111 by the first traction filament 131 may cause the plurality of first notches 111-1 on the first pipe body 111 to be closed with each other, so that the first pipe body 111 may bend. When the threaded traction block 635 stops moving, the first pipe body 111 may maintain a bending state. When the threaded traction block 635 loosens the first traction filament 131, the first pipe body 111 may reduce a bending degree under its own elastic force until returning to a natural state (such as maintaining a cylindrical shape) .

In some embodiments, as shown in FIG. 11, the delivery pipe control mechanism 600 may include a bending indication device 640. The bending indication device 640 may be configured to indicate a bending degree of the first pipe body 111. In some embodiments, the bending indication device 629 may include an indication block. The indication block may be engaged with an external thread of the screw 610 and move with the rotation of the screw 610. A position the indication block moves to may reflect the bending degree of the first pipe body 111. In some embodiments, a position the indication block moves to may correspond to a bending angle of the first pipe body 111 one to one. The corresponding relationship between the position the indication block moves to and the bending angle of the first pipe body 111 may be determined by experiments. In some embodiments, the bending indication device 640 may further include an indication mark. The indication mark may be disposed on a housing (such as a transparent housing covering the outside of the indication block) to intuitively reflect the bending degree (such as a bending angle) of the first pipe body 111 corresponding to a position the indication block moves to.

FIG. 12 is a partial sectional diagram illustrating an outer clamp arm control mechanism according to some embodiments of the present disclosure. FIG. 13 is a structural schematic diagram illustrating a sleeve according to some embodiments of the present disclosure. FIG. 14 is a decomposition structure diagram illustrating a sliding part and a protective cover according to some embodiments of the present disclosure. In some embodiments, as shown in FIGs. 12-14, the outer clamp arm control mechanism 400 may include a sleeve 410, a first control part 420, and a sliding part 430. The sliding part 430 may be disposed in the sleeve 410. The first control part 420 may rotate to drive the sliding part 430 to move in the sleeve 410 and along a length direction of the sleeve 410, so as to control the opening and closing of the outer clamp arm 220. If one end of the first control handle 300 close to the tissue clamping device 200 is defined as a front end, and the other end of the first control handle 300 is defined as a rear end, when the sliding part 430 moves toward the front end in the sleeve 410, the opening of the outer clamp arm 220 may be controlled to be opened (such as the first outer clamp arm 221 and the second outer clamp arm 223 are opened relative to each other) . When the sliding part 430 moves toward the rear end, the outer clamp arm 220 may be controlled to be closes (such as the first outer clamp arm 221 and the second outer clamp arm 223 are closed relative to each other) .

In some embodiments, the sleeve 410 may include one or more interlayers. The sliding part 430 may be disposed in the interlayers of the sleeve 410. The first control part 420 may drive the sliding part 430 to move in the sleeve 410 and along the length direction of the sleeve 410. For example, the sleeve 410 may have a hollow cylindrical shape, which may be formed by connecting two semi-cylindrical housings. The sliding part 430 may have a cylindrical shape and may be clamped between the two semi-cylindrical housings of the sleeve 410.

In some embodiments, referring to FIGs. 12 and 13, an external thread may be disposed on an outer circumferential surface of the sleeve 410. An internal thread may be disposed on an inner circumferential surface of the first control part 420. The sleeve 410 and the first control part 420 may be connected by the threads (i.e., the external thread and the internal thread) . One or more first sliding grooves 412 may be opened on the sleeve 410 along the length direction thereof. The sliding part 430 may be connected to the first control part 420 by passing through the first sliding groove (s) 412. Specifically, the sliding part 430 may include one or more protruding connection block (s) 429. The inner circumferential surface of the first control part 420 may include one or more connection grooves 421. The connection block (s) 429 may protrude from the first sliding groove (s) 412 and be clamped with the connection groove (s) 421, respectively, so that the first control part 420 may rotate to drive the sliding part 430 to move along the first sliding groove (s) 412. In some embodiments, the sleeve 410 may include two first sliding grooves 412, which are respectively disposed on two sides of the sleeve 410. The sliding part 430 may include two protruding connection blocks 429 corresponding to the two first sliding grooves 412, respectively, thereby ensuring the stability of the movement of the sliding part 430 driven by the first control part 420. In some alternative embodiments, a count of the first sliding grooves 412 may be other numbers, such as one, three, five.

In some embodiments, the first control part 420 may have a circular outer contour, and a rubber layer may be disposed on a surface of the outer contour. When an operator controls the outer clamp arm 220 by rotating the first control part 420, the rubber layer can increase the friction between the first control part 420 and the palm or fingers, so that the operator can precisely control the first control part 420. In some other embodiments, a layer made of hard materials such as plastic, metal may be disposed on the surface of the outer contour of the first control part 420 without the rubber layer, and anti-slip patterns may be added on the layer to increase the friction.

In some embodiments, as shown in FIGs. 12-14, the outer clamp arm control mechanism 400 may include a control rod 440, a fixing block 460, and a protective cover 470. The sliding part 430 may control the opening and closing of the outer clamp arm 220 by the control rod 440, and a rear end (e.g., a right end in FIG. 13) of the control rod 440 may be fixedly connected to the fixing block 460. Specifically, the fixing block 460 may be cylindrical, and a cross-sectional diameter thereof may be larger than that of the control rod 440. The control rod 440 may be inserted into and fixedly connected to the fixing block 460 in a manner such as glue connection, welding connection, or interference connection. The protective cover 470 may be detachably connected to the sliding part 430 by a thread. When connected to the sliding part 430, the protective cover 470 may restrict the relative movement of the fixing block 460 and the sliding part 430. In some embodiments, the control rod 440 may be made of a memory alloy (such as a nickel-titanium alloy) , so that the control rod 440 can have relatively good tensile and compressive properties and relatively good bending performance. Thus, although the delivery pipe 100 is bent, the outer clamp arm control mechanism 400 may also effectively control the opening and closing of the outer clamp arm 220 by the control rod 440.

In some embodiments, after the clamping of the tissue clamping device 200 is completed, the control rod 440 needs to be separated from the tissue clamping device 200, and part or whole of the control rod 440 may be drawn out from the first control handle 300. As shown in FIGs. 12-14, the protective cover 470 may be detachably connected to the sliding part 430 by the thread. When the control rod 440 needs to be separated from the tissue clamping device 200, the operator may rotate the protective cover 470 to separate the control rod 440 from the sliding part 430, rotate the fixing block 460 (that is, rotate the control rod 440) to separate the control rod 440 from the tissue clamping device 200, and pull the fixing block 460 to draw out the control rod 440 from the first control handle 300.

FIG. 15 is a partial sectional diagram illustrating an inner clamp arm control mechanism according to some embodiments of the present disclosure. FIG. 16 is a structural schematic diagram illustrating a housing according to some embodiments of the present disclosure. FIG. 17 is a structural schematic diagram illustrating a second control part according to some embodiments of the present disclosure. FIG. 18 is a structural schematic diagram illustrating a second control part and a locking mechanism at a first perspective according to some embodiments of the present disclosure. FIG. 19 is a structural schematic diagram illustrating a second control part and a locking mechanism at a second perspective according to some embodiments of the present disclosure. In some embodiments, as shown in FIGs. 15-19, the inner clamp arm control mechanism 500 may include the housing 510 and a second control part 520. A second sliding groove 511 may be opened on the housing 510. The second control part 520 may pass through and move along the second sliding groove 511 to control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220.

In some embodiments, as shown in FIG. 17, the second control part 520 may include an L-shaped duct 521 and an end cover 523. One end of the duct 521 may pass through the second sliding groove 511 and be detachably connected to the end cover 523. During operation, the second control part 520 may slide in the second sliding groove 511 by pushing and pulling the duct 521 at the end cover 523. By disposing the L-shaped duct 521, it may be more convenient for the operator to operate. In some embodiments, the second control part 520 may be drivingly connected to the inner clamp arm 210 by a control cable. In some embodiments, the control cable may pass through the through hole at a movable end of the inner clamp arm 210, and both ends of the control cable may be fixed at the end cover 523. When it is necessary to separate the tissue clamping device 200 from the first control handle 300, the end cover 523 and the duct 521 may be separated to release the fixing of the two ends of the control cable and the control cable may be drawn out, so that the first control handle 300 may be separated from the inner clamp arm 210. In some embodiments, releasing the fixing of the two ends of the control cable may include: releasing the connection between the two ends of the control cable and the end cover 523, untying the knot formed at both ends of the control cable, cutting the control cable, or the like, or any combination thereof. In some embodiments, the control cable may be incompletely removed from the first control handle 300, and just detached from the inner clamp arm 210.

In some embodiments, as shown in FIG. 16, the second sliding groove 511 may be in an elongated shape. When the end cover 523 of the second control part 520 (or a portion of the duct 521 protruding from the second sliding groove 511) moves to the rear end (e.g., an end away from the tissue clamping device 200) of the second sliding groove 511, the inner clamp arm 210 may be in a closed state. In some alternative embodiments, the second sliding groove 511 may have an L-shaped contour. Specifically, a passage may be opened at the rear end of the second sliding groove 511 and along a direction that forms an angle (e.g., 90°) with the second sliding groove 511. When the end cover 523 of the second control part 520 (or the portion of the duct 521 protruding from the second sliding groove 511) moves to the rear end of the second sliding groove 511, the second control part 520 may be pushed and pulled laterally so that the part of the duct 521 protruding from of the second sliding groove is clamped into the channel. In this way, the inner clamp arm 210 may be kept in a folded state (i.e., the closed state) , thereby preventing misoperation during the operation.

In this embodiment, the second sliding groove 511 may include a first sub-sliding groove and a second sub-sliding groove, that are set on both sides of the housing 510. The second control part 520 may include a first sub-control part for controlling the first inner clamp arm 211 and a second sub-control part for controlling the second inner clamp arm 213. The first sub-control part and the second sub-control part may respectively correspond to separate control cables. In some embodiments, the first sub-control part and the second sub-control part (i.e., the second control part 520) may be operated successively or simultaneously according to actual needs, so as to accurately control the first inner clamp arm 211 and the second inner clamp arm 213 (i.e., the inner clamp arm 210) according to the needs of experiments or surgery. For example, during the mitral valve repair process, the first inner clamp arm 211 may be controlled to clamp one side of the mitral valve, and then the second inner clamp arm 213 may be controlled to clamp the other side of the mitral valve. As another example, the second control part 520 may simultaneously control the first inner clamp arm 211 and the second inner clamp arm 213 to clamp the mitral valve.

In some embodiments, one end of the housing 510 may be connected (or integrally formed) with the sleeve 410, and central axes of the housing 510 and the sleeve 410 may coincide, making the first control handle 300 more compact and easier to handle. For example, the housing 510 may be disposed at an end of the sleeve 410 near the tissue clamping device 200, and when the first control part 420 is in contact with the rear end of the housing 510, the outer clamp arm 220 may be in a maximum opened state. In some alternative embodiments, the housing 510 may be disposed at the end of the sleeve 410 away from the tissue clamping device 200.

In some embodiments, as shown in FIGs. 15-19, the inner clamp arm control mechanism 500 may include a locking mechanism 530. The locking mechanism 530 may include an elastic member 531, one or more locking buttons 533, and one or more locking blocks 535. The second control part 520 may further include one or more tooth-shaped connecting parts 537. The locking button (s) 533 may be configured to control the locking block (s) 535 to overcome an elastic force of the elastic member 531, so as to release the restriction of the locking block (s) 535 on the tooth-shaped connecting part (s) 537.

As shown in FIGs. 15-19, in this embodiment, the locking mechanism 530 may include a pair of oppositely disposed locking blocks 535, and the first sub-control part and the second sub-control part may include tooth-shaped connecting parts 537 corresponding to the locking blocks 535, respectively. Specifically, the tooth-shaped connecting parts 537 may be connected to or integrally formed with the duct 521 of the first sub-control part and the second sub-control part, respectively. The pair of oppositely disposed locking blocks 535 may be configured to restrict the movement of the first sub-control part and the second sub-control part under the elastic force of the elastic member 531, respectively. For example, one of the pair of locking blocks 535 corresponding to the first sub-control part may be snapped into one of the tooth-shaped connection parts 537 corresponding to the first sub-control part under the elastic force of the elastic member 531. The other one of the pair of locking blocks 535 corresponding to the second sub-control part may be snapped into the other one of the tooth-shaped connecting parts 537 corresponding to the second sub-control part under the elastic force of the elastic member 531. In this embodiment, the elastic member 531 may be two springs. There may be two locking buttons 533, which are respectively connected to two locking blocks 535. The locking buttons 533 may be exposed from the housing 510. Taking the operation of the first sub-control part as an example, when one of the locking buttons 533 corresponding to the first sub-control part is pressed, it may drive the corresponding locking block 535 to overcome the elastic force of the elastic member 531 so as to disengage from the corresponding tooth-shaped connecting part 537. The operator may push or pull the first sub-control part (such as the duct 521 of the first sub-control part) to slide in the first sub-sliding groove corresponding to the first sub-control part to control the opening and closing of the first inner clamp arm 211. When the operator releases the one of the locking buttons 533 corresponding to the first sub-control part, under the elastic force of the elastic member 531, the locking block 535 may be re-snapped into the corresponding tooth-shaped connecting part 537 to restrict the movement of the tooth-shaped connecting part 537 (that is, the movement of the duct 521) . The operation on the second sub-control part may be similar to that on the first sub-control part, which is not repeated herein.

In some embodiments, a mark may be added to each of the locking buttons 533 in order to facilitate the operator to distinguish them. The mark may include "left" , "right" , "L" , "R" , an arrow, or the like, or any combination thereof.

The beneficial effects of the delivery pipe and/or the tissue repair device of the present disclosure may include but are not limited to: (1) the delivery pipe has the functions of tissue clamping device delivery and bending adjustment, making the corresponding medical equipment (such as a tissue repair device) more convenient in operation; (2) quickly and accurately adjusting the bending of the delivery pipe; (3) effectively reducing the space required by the delivery pipe during adjusting the bending of the delivery pipe through the cooperation of the traction mechanism and the first pipe body, which is suitable for various surgeries; (4) quickly and accurately controlling the outer clamp arm and/or the inner clamp arm of the tissue clamping device; (5) making the operation of valve repair more convenient, the repair efficiency and success rate are higher. It should be noted that different embodiments may have different beneficial effects. In different embodiments, the possible beneficial effects may be any one or a combination of the above, or any other possible beneficial effect.

The embodiments of the present disclosure may also relate to a guide pipe and a tissue repair device. In surgical surgery, some components of the medical equipment may be delivered to a designated position of the body, for example, in the surgical surgery of mitral valve, the tissue clamping device that clamps the mitral valve in the mitral valve repair device may be delivered to the mitral valve of the heart. In addition, the guide pipe may also be used for endoscopic surgery, heart stent surgery, drug perfusion surgery, vascular embolization surgery, artificial insemination surgery, etc. The guide pipe may need to move in the body to deliver the components of the medical equipment, for example, in mitral valve repair surgery, the guide pipe may need to move in the blood vessel. In traditional situations, the guide pipe can only be bent in one direction, when the movement direction of the guide pipe needs to be changed during the movement of the guide pipe or during the surgery process, the guide pipe may need to be rotated as a whole, which is inconvenient to operate.

In some embodiments of the present disclosure, the guide pipe may include at least two second traction filaments passing through a third pipe body and a fourth pipe body. The at least two second traction filaments may be able to be tensioned, respectively, to control the third pipe body to bend to different directions. By providing at least two second traction filaments, when different second traction filaments are tensioned, the third pipe body may be bent to different directions (e.g., the third pipe body may be bent to the tensioned direction) . When delivering the medical equipment to the body via the guide pipe, it may be easy to change the movement direction of the guide pipe in the body (such as the blood vessel) , so that the medical equipment may be quickly delivered to the position to be operated, thereby ensuring the efficient operation of the surgery, and reducing the risk of the surgery. The guide pipe of the present disclosure may be used in tissue repair device, such as equipment configured to repair the mitral valve, the tricuspid valve, the vascular valve, etc. The guide pipe of the present disclosure may also be used for endoscopic surgery equipment, such as laparoscopic, gastroscope, colonoscopy, etc., or heart stent surgery equipment, drug perfusion surgery equipment, vascular embolization surgery equipment, artificial insemination surgery equipment, etc.

In some embodiments, the delivery pipe of the tissue clamping device may cooperate with the guide pipe to complete the tissue repair surgery. In some embodiments, the delivery pipe of the tissue clamping device may pass through the inside of the guide pipe. Under the guidance of the guide pipe, the delivery pipe may deliver the tissue clamping device to the designated position more conveniently. For example, in the process of repairing mitral valve, the guide pipe may be inserted into the human body first, and then, the delivery pipe of the tissue clamping device may quickly deliver the tissue clamping device to the designated position (such as the mitral valve) via the guide pipe.

FIG. 20 is a structural schematic diagram illustrating a guide pipe according to some embodiments of the present disclosure. As shown in FIG. 20, the guide pipe may include a bend structure 1100 and at least two second traction filaments 1200. The bend structure 1100 may include a third pipe body 1110 and a fourth pipe body 1120. One end (e.g., the right end shown in the figure) of the third pipe body 1110 may be connected to the fourth pipe body 1120. The at least two second traction filaments 1200 may pass through the third pipe body 1110 and the fourth pipe body 1120 along length directions of the third pipe body 1110 and the fourth pipe body 1120. One end of each of the at least two second traction filaments 1200 may be fixed to another end (e.g., the left end shown in the figure) of the third pipe body 1110. The at least two second traction filaments 1200 may be able to be tensioned, respectively, to control the third pipe body 1110 to bend to different directions. The two second traction filaments 1200 are tensioned, respectively, may refer that one or more of the at least two second traction filaments 1200 are tensioned and the remaining second traction filaments 1200 are relaxed (or no force is applied to the remaining second traction filaments 1200) . When different second traction filaments 1200 are tensioned, the third pipe body 1110 may be bent to different directions.

The third pipe body 1110 and the fourth pipe body 1120 may both have pipe structures. In some embodiments, the pipe structure may be a straight pipe with an equal diameter from one end to the other end, for example, the pipe structure may be cylindrical. In some alternative embodiments, the pipe structure may be a reduced diameter pipe whose diameter is tapered from one end to the other end. For example, the pipe structure may be conical. The pipe structure of the third pipe body 1110 and the fourth pipe body 1120 may be the same or unidentical. The material of the third pipe body 1110 and the fourth pipe body 1120 may be stainless steel, shape memory alloy (such as Nitinol) , etc. The material of the third pipe body 1110 and the fourth pipe body 1120 may be the same or unidentical.

In some embodiments, the number of the second traction filaments 1200 may be any number such as two, three, four, or six. The bending direction of the third pipe body 1110 may be designed according to the application scenario of the guide pipe 1000, so as to set the number of the second traction filaments 1200. For example, if the third pipe body 1110 needs to be bent to two, three, or four different directions, the number of the second traction filaments 1200 may be set to two, three, and four correspondingly. Further, according to the bending direction of the third pipe body 1110, the connection between one end of each of the second traction filament 1200 and the third pipe body 1110 may be determined. For example, if the third pipe body 1110 needs to be bent to two opposite directions, there may be two second traction filaments 1200, and the connections of the two second traction filaments 1200 and the third pipe body 1110 may be located in a radial direction at both ends of the third pipe body 1110, respectively.

In some embodiments, the third pipe body 1110 may have elasticity. When part of the second traction filaments 1200 is tensioned, the third pipe body 1110 may be elastically deformed and bent. In other embodiments, part of the second traction filaments 1200 may be tensioned while part of the second traction filaments 1200 may be relaxed, the third pipe body 1110 may be bent, for example, to the second traction filaments 1200 that is tensioned.

In some embodiments, the at least two second traction filaments 1200 may include two second traction filaments located in a radial direction of the bend structure 1100 at both ends of the bend structure 1100, respectively. When one of the second traction filaments 1200 is tensioned, another of the second traction filaments 1200 may be relaxed. Two second traction filaments are located in a radial direction of the bend structure 1100 at both ends of the bend structure 1100, may refer that the connection of the two second traction filaments 1200 and the third pipe body 1110 may be located at both ends of the third pipe body 1110 in the radial direction, respectively, or the two second traction filaments 1200 may be located at both ends of the third pipe body 1110 in the radial direction of the third pipe body 1110, respectively, or the two second traction filaments 1200 may be located at both ends of the fourth pipe body 1120 in the radial direction of the fourth pipe body 1120, respectively. In the embodiment, the total number of the second traction filaments 1200 may be any number such as two, three, four, or six. Merely as an example, if the number of the second traction filaments 1200 is three, two of the second traction filaments 1200 may be arranged opposite to each other; if the number of the second traction filaments 1200 is four, only two of the second traction filaments 1200 may be arranged opposite to each other, or four second traction filaments 1200 may be arranged opposite to each other.

In some embodiments, the guide pipe 1000 may further include an outer layer structure (not shown in the figure) and an inner layer structure (not shown in the figure) . The outer layer structure, the bend structure 1100 and the inner layer structure may be arranged in sequence from the outside to the inside along the radial direction of the guide pipe 1000. The outer layer structure may prevent the blood of the body from contacting the metal part of the guide pipe 1000 (e.g., the third pipe body 1110, or the fourth pipe body 1120) . The relatively smooth outer surface of the outer layer structure may reduce the friction between the guide pipe 1000 and the body, and the risk of the guide pipe 1000 damaging the body, and facilitate the corresponding surgery. In some embodiments, the material of the outer layer structure may include a thermoplastic material. For example, the thermoplastic material may include polyether block amide (PEBAX) , polyurethane, polyamide, polyimide, polyethylene, polypropylene, polytetrafluoroethylene, etc., or any combination thereof. The thermoplastic material may have high stability, fatigue resistance, good resilience and elastic recovery performance at a relatively low temperature, which may improve the accuracy of adjusting the bending of the guide pipe 1000. In some embodiments, in order to further reduce the friction between the guide pipe 1000 and the body, the surface of the outer layer structure may also be equipped with a hydrophilic coating. In some embodiments, the material of the hydrophilic coating may include polyacrylic acid, silicon dioxide, polysiloxane, siloxane, urethane, etc., or any combination thereof. The friction coefficient of the inner layer structure is relatively small, which may facilitate the loading of materials required for interventional surgery to pass through the guide pipe 1000, so that the medicine or other pipe bodies entering the guide pipe 1000 may smoothly enter the target area of the body. In some embodiments, the material of the inner layer structure may include nylon, polyether block amide (PEBAX) , polytetrafluoroethylene (PTFE) , fluorinated ethylene propylene, perfluoroalkoxy alkane, polyterephthalic acid ethylene glycol ester, polyether ether ketone, etc., or any combination thereof. In some embodiments, the inner layer may include one or more layers.

FIG. 21 is a schematic diagram illustrating the connection among a fixing ring of a guide pipe, a second traction filament, and a third pipe body according to some embodiments of the present disclosure. As shown in FIG. 21, the bend structure 1100 may include a fixing ring 1130. The fixing ring 1130 may be connected (e.g., via a fixedly connection) to another end of the third pipe body 1110. The one end of each of the two second traction filaments 1200 may be fixed to the fixing ring 1130. The second traction filaments 1200 and the fixing ring 1130 may be fixed by bonding connection, welding connection, etc. The at least two second traction filaments 1200 and the third pipe body 1110 may be fixed more conveniently by using the fixing ring 1130. The material of the fixing ring 1130 may include stainless steel, shape memory alloy (such as Nitinol) , etc.

In some embodiments, as shown in FIG. 21, a mounting hole 1131 may be disposed on the fixing ring 1130, and the mounting hole 1131 may be configured to fix the inner layer structure and/or the outer layer structure. Merely as an example, when an outer layer structure of a polymer material is arranged on the outer surface of the bend structure 1100 (e.g., an outer layer structure of a heat-condensed polyether block polyamide (Pebax) material) , the outer layer structure of the polymer material on the outer surface of the third pipe body 1110, a fixing member, and the fourth pipe body 1120 may be in a molten state at a relatively high temperature during the preparation process, and the polymer material in the molten state may flow into the mounting hole 1131. The third pipe body 1110, the fixing member, the fourth pipe body 1120 may be fixedly connected with each other after the polymer material in the molten state is cooled. Due to the arrangement of the mounting hole 1131, the polymer material flowing into the mounting hole 1131 may make the outer layer structure wrap more stably on the outer surface of the bend structure 1100. In the same way, the mounting hole 1131 may make the inner layer structure more stably disposed on the inner surface of the bend structure 1100.

FIG. 22 is a structural schematic diagram illustrating a third pipe body of a guide pipe according to another embodiment of the present disclosure. As shown in FIG. 22, the third pipe body 1110 may include a first sub-pipe body formed by spiral winding of a first wire strip 1111 and a second sub-pipe body woven from a second wire strip 1112, the second sub-pipe body may be sleeved outside the first sub-pipe body. The first sub-pipe body may be formed by spiral winding of the first wire strip 1111, thus the first sub-pipe body may be a spring-tube-like structure, and the first sub-pipe body may be bent smoothly, which may facilitate the bending adjustment control of the guide pipe 1000. The second sub-pipe body woven from the second wire strip 1112 may have a better torsion feedback effect. The operator may better control the torsional direction of the guide pipe 1000 in the actual operation via the second sub-pipe body sleeved outside the first sub-pipe body.

FIG. 23 is a structural schematic diagram illustrating a fourth pipe body 1120 of a guide pipe 1000 according to another embodiment of the present disclosure. As shown in FIG. 23, the fourth pipe body 1120 may be woven from the second wire strip 1112. The second wire strip 1112 may be woven into a mesh. On the one hand, the fourth pipe body 1120 woven from the second wire strip 1112 may have better torque control performance. When the guide pipe 1000 is rotated as a whole, the fourth pipe body 1120 may transmit torque to drive the third pipe body 1110 to rotate. On the other hand, the fourth pipe body 1120 woven from the second wire strip 1112 may have good extrusion resistance and bending resistance. When the guide pipe 1000 enters human tissues (such as blood vessels, atrial walls, etc. ) , the fourth pipe body 1120 composed of mesh woven structure may withstand the extrusion of human tissues, so that the fourth pipe body 1120 may maintain a normal shape. In addition, when the second traction filaments 1200 is tensioned, the second traction filaments 1200 may drive the third pipe body 1110 and the fourth pipe body 1120 to bend, and the fourth pipe body 1120 may have a relatively high bending resistance, so that the second traction filaments 1200 may have little bending effect on the fourth pipe body 1120, thereby, the second traction filaments 1200 may better control the bending of the third pipe body 1110.

In some embodiments, the second sub-pipe body and the fourth pipe body 1120 may be connected by welding connection, bonding connection, etc. In other embodiments, the second sub-pipe body and the fourth pipe body 1120 may be in an integral structure. By setting the second sub-pipe body and the fourth pipe body 1120 as an integral structure, the manufacturing and assembly process of the guide pipe 1000 may be simplified.

FIG. 24 is a structural schematic diagram illustrating a first sub-pipe body of a third pipe body according to some embodiments of the present disclosure. As shown in FIG. 24, the first wire strip 1111 forming the first sub-pipe body may include a first sub-wire strip 1111-1 and a second sub-wire strip 1111-2. The first sub-wire strip 1111-1 and the second sub-wire strip 1111-2 may be alternate and spiral winding. The cross-sections of the first wire strip 1111 and the second sub-wire strip 1111-2 may be different. The cross-section of the first sub-wire strip 1111-1 may be of a rectangular shape, a rectangular shape having a chamfer, or an irregular shape having parallel edges. The cross-section of the second sub-wire strip 1111-2 may have an arc contour. The alternate and spiral winding may refer that the first sub-wire strip 1111-1 and the second sub-wire strip 1111-2 are arranged in parallel and spiral winding in a specific direction. In the embodiments of the present disclosure, the specific direction may refer to the direction from one end to the other end of the pipe structure. For example, the left-to-right or right-to-left direction shown in FIG. 24. The first sub-pipe body formed by the alternate and spiral winding of the first sub-wire strip 1111-1 and the second sub-wire strip 1111-2 with different cross-sections may have both good bending resistance and transitional property.

The cross-section having parallel edges may refer that the cross-section includes at least two edges, and the two edges may be opposite and parallel. In some embodiments, the cross-section of the first sub-wire strip 1111-1 may include polygons such as a rectangle, a parallelogram, a trapezoid, a hexagon, etc. Preferably, the cross-section of the first sub-wire strip 1111-1 may be of a rectangular shape or a rectangular shape having a chamfer. In some alternative embodiments, the cross-section of the first sub-wire strip 1111-1 may be of an irregular shape having parallel edges. For example, the cross-section of the first sub-wire strip 1111-1 may be designed based on a rectangle, and two opposite edges of the rectangle may be arc-shaped edges or wavy edges that protrude outward or recess inward. In some embodiments, the parallel opposite edges of the cross-section of the first sub-wire strip 1111-1 may be located on the outside and the inside of the first sub-pipe body, respectively. Compared with a first sub-pipe body formed by the alternate and spiral winding of circular wire strips, whose adjacent wire strips may overlap each other and be easily deformed when the first sub-pipe body is bent, the first sub-pipe body including the first sub-wire strip 1111-1 may have better bending resistance, and may maintain a bent state when the first sub-pipe body is bent without being easily deformed. In addition, the parallel opposite edges of the cross-section of the first sub-wire strip 1111-1 located on the inside and outside of the first sub-pipe body may ensure that the outside and the inside of the first sub-pipe body remain smooth, so that the first sub-pipe body served as a supporting pipe structure may remain smooth. For example, when the first sub-pipe body served as a supporting pipe structure is used as the guide pipe 1000 intervened in the body, the guide pipe 1000 may reduce the corresponding resistance and friction when entering the blood vessel or heart of the body, and avoid damage to the body. In addition, the inner smoothness of the guide pipe 1000 supported by the first sub-pipe body may facilitate the movement of the pipe body containing the heart valve or medicine inside.

The second sub-wire strip 1111-2 having an arc contour may enhance the transition of the first sub-pipe body in the bending process, thus the first sub-pipe body may be easier to bend and the bending degree may be more uniform everywhere, thereby, the first sub-pipe body may be easier to control and the adjusting efficiency of the bending degree may be improved. In some embodiments, the cross-section of the second sub-wire strip 1111-2 may include, but is not limited to, a circle (as shown in FIG. 24) , an ellipse, a semicircle, etc. It should be noted that the cross-section of the second sub-wire strip 1111-2 may not be limited to the regular circle, ellipse, or semicircle mentioned above. For example, the cross-section of the second sub-wire strip 1111-2 may also be a semi-ellipse, a 3/4 ellipse, a 3/4 circle, etc.

FIG. 25 is a structural schematic diagram illustrating a guide pipe according to another embodiment of the present disclosure. FIG. 26 is a schematic structural diagram illustrating a third pipe body of a guide pipe according to another embodiment of the present disclosure. FIG. 27 is a structural diagram illustrating a fourth pipe body of a guide pipe according to another embodiment of the present disclosure. As shown in FIGs. 25-27, the third pipe body 1110 may be equipped with a plurality of second notches 1113 along a length direction of the third pipe body 1110, and opening directions of two adjacent second notches 1113 may be different. The third pipe body 1110 may bend to opening directions of the plurality of second notches 1113. The third pipe body 1110 may be easily bent, and the third pipe body 1110 may be bent in a specific direction through the arrangement of the plurality of second notches 1113. Merely as an example, when the third pipe body 1110 needs to be bent in two opposite directions, the number of the second traction filaments 1200 may be set to two, and the opening directions of two adjacent second notches 1113 may be opposite to each other. Alternatively, when the third pipe body 1110 needs to be bent in three different directions, the number of the second traction filaments 1200 may be set to three, and the opening directions of three adjacent second notches 1113 may be different from the circumferential directions of the third pipe body 1110.

In some embodiments, the third pipe body 1110 may be integrally formed by cutting a metal tube. The metal tube may be a stainless steel tube, a shape memory alloy tube (such as a nickel-titanium alloy tube) , etc. The fourth pipe body 1120 may be woven from a third wire strip 1114. The structure and effect of the fourth pipe body 1120 woven from the third wire strip 1114 may be similar to the structure and effect of the fourth pipe body 1120 woven from the second wire strip 1112 described above, which may not be repeated herein.

In some embodiments, as shown in FIG. 25, in order to facilitate the stable connection of the third pipe body 1110 and the fourth pipe body 1120, a connection ring 1140 may be arranged between the third pipe body 1110 and the fourth pipe body 1120. The material of the connection ring 1140 may be the same as or different from the material of the metal tube. In some embodiments, the connection ring 1140 may be integrally formed with the third pipe body 1110, that is, the third pipe body 1110 and the connection ring 1140 may be integrally formed by cutting the metal tube, and the connection ring 1140 may be connected to the fourth pipe body 1120 by bonding connection, welding connection, etc. In other embodiments, the connection ring 1140 may be connected to the third pipe body 1110 by bonding connection, welding connection, etc.

Another embodiment of the present disclosure further provides a tissue repair device. The tissue repair device may include the guide pipe 1000 of any of the technical solutions mentioned above. The tissue repair device may deliver the medical equipment for repairing the tissue (such as the delivery pipe of a tissue clamping device) to the optimal position of the body via the guide pipe 1000 described above. The tissue repair device may quickly and conveniently deliver the medical equipment via the guide pipe 1000, thereby ensuring the efficient operation of the surgery and reducing the risk of the surgery.

FIG. 28 is a structural schematic diagram illustrating a tissue repair device according to some embodiments of the present disclosure. FIG. 29 is a structural schematic diagram illustrating a guide pipe control assembly of a second control handle of a tissue repair device according to some embodiments of the present disclosure. As shown in FIG. 28, the tissue repair device may include a second control handle 2000. The second control handle 2000 may include a housing 2100 and a guide pipe control assembly 2200 (not shown in FIG. 29) disposed within the housing 2100, the guide pipe control assembly 2200 may be configured to control the plurality of second traction filaments 1200 of the guide pipe 1000 to be tensioned respectively to control the third pipe body 1110 of the bend structure 1100 of the guide pipe 1000 to bend to different directions. In some embodiments, one end of the fourth pipe body 1120 of the guide pipe 1000 away from the third pipe body 1110 may be fixed to the housing 2100 or the guide pipe control assembly 2200, and one end of the two second traction filaments 1200 away from the third pipe body 1110 may be connected to the guide pipe control assembly 2200, so as to realize the bending control of the third pipe body 1110 by the guide pipe control assembly.

In some embodiments, a count of the second traction filaments 1200 may be two (not shown in figures) . As shown in FIG. 29 and FIG. 30, one end of the fourth pipe body 1120 of the bend structure 1100 of the guide pipe 1000 away from the third pipe body 1110 may be fixed to the housing 2100. The guide pipe control assembly 2200 may include a threaded sleeve 2210, a first traction component 2220, and a second traction component 2230. One end of the two second traction filaments 1200 away from the fixing ring 1130 may be connected to the first traction component 2220 and the second traction component 2230, respectively; the threaded sleeve 2210 may be equipped with a first thread and a second thread, and a rotation direction of the first thread may be opposite to a rotation direction of the second thread, the first traction component 2220 may be connected to the threaded sleeve 2210 through coordination with the first thread, and the second traction component 2230 may be connected to the threaded sleeve 2210 through coordination with the second thread. When the threaded sleeve 2210 is rotated, the first traction component 2220 and the second traction component 2230 may be able to move in opposite directions along a length direction of the threaded sleeve 2210 to make one of the two second traction filaments 1200 be tensioned and another of the two second traction filaments 1200 be relaxed. For example, when the first traction component 2220 moves forward along the length direction of the threaded sleeve 2210 (e.g., toward the direction close to the third pipe body 1110) , the second traction filaments 1200 connected to the first traction component 2220 may be relaxed. At the same time, the second traction component 2230 may move backward (e.g., toward the direction away from the third pipe body 1110) along the length direction of the threaded sleeve 2210, and the second traction filaments 1200 connected to the second traction component 2230 may be tensioned.

In some embodiments, as shown in FIG. 28, the guide pipe control assembly 2200 may include a runner 2400, the runner 2400 may be connected to the threaded sleeve 2210, and may rotate relative to the housing 2100. When the operator rotates the runner 2400, the runner 2400 may drive the threaded sleeve 2210 to rotate. In some embodiments, the runner 2400 may be equipped with a non-slip structure (such as a non-slip groove or a non-slip protrusion) to facilitate the operator to rotate the runner 2400.

In some embodiments, the first thread and the second thread may be an external thread 2310 disposed on an outer wall of the threaded sleeve 2210, the first traction component 2220 and the second traction component 2230 may be disposed outside of the threaded sleeve 2210. In some embodiments, the guide pipe 1000 may penetrate into the threaded sleeve 2210.

In some embodiments, the first thread and the second thread may be internal threads located on an inner wall of the threaded sleeve 2210, the first traction component 2220 and the second traction component 2230 may be disposed in the threaded sleeve 2210. FIG. 30 is a structural schematic diagram illustrating a first traction component and a second traction component of a second control handle of a tissue repair device according to some embodiments of the present disclosure. As shown in FIG. 30, the first traction component 2220 may include a first accommodation groove 2221, the second traction component 2230 may include a second accommodating groove 2231, the first accommodation groove 2221 and the second accommodation groove 2231 may be disposed oppositely, and a portion of the guide pipe 1000 may be housed in the first accommodation groove 2221 and the second accommodation groove 2231. The shape and size of the first accommodation groove 2221 and the second accommodation groove 2231 may match the shape and size of the guide pipe 1000. In some embodiments, the third pipe body 1110 and the fourth pipe body 1120 of the guide pipe 1000 may both be cylindrical tubular structures, and the first accommodation groove 2221 and the second accommodation groove 2231 may both be arc-shaped grooves. Preferably, the first accommodation groove 2221 and the second accommodation groove 2231 may both be grooves with a cross-section of a semicircular arc; when the first accommodation groove 2221 and the second accommodation groove 2231 are arranged oppositely, the first accommodation groove 2221 and the second accommodation groove 2231 may form a cylindrical accommodation space, and a portion of the guide pipe 1000 may be accommodated in the accommodation space. The size of the accommodation space may be slightly larger than the size of the guide pipe 1000 (e.g., the inner diameter of the accommodation space may be slightly larger than the diameter of the guide pipe 1000) .

In some embodiments, the second control handle 2000 may include a mounting pipe 2500, the guide pipe 1000 may be inserted into the mounting pipe along a length direction of the mounting pipe 2500, and a portion of the mounting pipe 2500 may be accommodated in the first accommodation groove 2221 and the second accommodation groove 2231. By arranging a portion of the guide pipe 1000 or the mounting pipe 2500 in the first accommodation groove 2221 and the second accommodation groove 2231, when the first traction component 2220 and the second traction component 2230 move, the guide pipe 1000 or the mounting pipe 2500 may guide and restrict the movement of the first traction component 2220 and the second traction component 2230.

In some embodiments, as shown in FIG. 30, a first connecting struct 2222 may be disposed on the first traction component 2220, and a second connecting struct 2232 may be disposed on the second traction component 2230. The first connecting struct 2222 and the second connecting struct 2232 may both be configured to fix the second traction filaments 1200. For example, two of the second traction filaments 1200 may be connected to the first connecting struct 2222 and the second connecting struct 2232, respectively. The connection of the second traction filaments 1200 with the first connecting struct 2222 and the second connecting struct 2232 may be winding and binding connection, winding and bonding connection, clamping connection, welding connection, etc.

FIG. 31 is a structural schematic diagram illustrating a bending indicator assembly of a second control handle of a tissue repair device according to some embodiments of the present disclosure. As shown in FIG. 31, the second control handle 2000 may further include a bending indicator assembly 2300. The bending indicator assembly 2300 may be configured to indicate the bending degree of the third pipe body 1110. The bending indicator assembly 2300 may include an external thread 2310 disposed on an outer wall of the threaded sleeve 2210, a position indicating mechanism 2320 may be connected to the threaded sleeve 2210 in coordination with the external thread 2310, and an indication identifier 2330 (shown in FIG. 28) may be disposed on the housing 2100. The position indicating mechanism 2320 may be able to move along the length direction of the threaded sleeve 2210 when the threaded sleeve 2210 rotates. When the position indicating mechanism 2320 moves along the length direction of the threaded sleeve 2210, the relative position of the position indicating mechanism 2320 and the housing 2100 may change, so that the relative position of the position indicating mechanism 2320 and the indication identifier 2330 may also change, the relative position of the position indicating mechanism 2320 and the indication identifier 2330 may reflect the bending degree of the third pipe body 1110. In some embodiments, the moving position of the position indicating mechanism 2320 may correspond to the bending angle of the third pipe body 1110 on a one-to-one basis. The corresponding relationship between the position indicating mechanism 2320 and the third pipe body 1110 may be determined via experiments. In some embodiments, the housing 2100 may be transparent and cover the position indicating mechanism 2320, and the indication identifier may be arranged on the transparent housing 2100 to visually reflect the correspondence bending degree of the third pipe body 1110 (such as bending angle) when the position indicating mechanism 2320 moves to a specific position. Merely as an example, the indication identifier 2330 may be a scale mark set along the length direction of the threaded sleeve 2210.

In some embodiments, the housing 2100 may be equipped with an elongated opening, and the length of the elongated opening may be parallel to the length of the threaded sleeve 2210. The position indicating mechanism 2320 may protrude from the elongated opening to the outside of the housing 2100. The indication identifier 2330 may be disposed beside the elongated opening.

The beneficial effects of the guide pipe of the present disclosure may include but are not limited to: (1) when different second traction filaments are tensioned, the third pipe body may bend to different directions via at least two second traction filaments, thus, when the guide pipe is configured to deliver medical equipment into the body, the movement direction of the guide pipe in the body may be easily changed, and the medical equipment may be quickly delivered to the position to be operated, thereby ensuring the efficient operation of the surgery and reducing the risk of the surgery; (2) at least two second traction filaments may be installed conveniently, and the inner layer structure and the outer layer structure may be conveniently set via the fixing ring; (3) the medical equipment may be delivered conveniently, and at the same time, the bending of the guide pipe may be controlled conveniently through the structural design of the third pipe body and the fourth pipe body; (4) the first sub-pipe body formed by the alternate and spiral winding of the first sub-wire strip and the second sub-wire strip with different cross-sections may have both good bending resistance and transitional property. It should be noted that different embodiments may have different beneficial effects. In different embodiments, the possible beneficial effects may be any one or a combination of the above, or any other beneficial effects that may be obtained.

Having thus described the basic concepts, it may be rather apparent to those skilled in the art after reading this detailed disclosure that the foregoing detailed disclosure is intended to be presented by way of example only and is not limiting. Various alterations, improvements, and modifications may occur and are intended to those skilled in the art, though not expressly stated herein. These alterations, improvements, and modifications are intended to be suggested by this disclosure and are within the spirit and scope of the exemplary embodiments of this disclosure.

Moreover, certain terminology has been used to describe embodiments of the present disclosure. For example, the terms “one embodiment, ” “an embodiment, ” and “some embodiments” mean that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present disclosure. Therefore, it is emphasized and should be appreciated that two or more references to “an embodiment” or “one embodiment” or “an alternative embodiment” in various portions of this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures or characteristics may be combined as suitable in one or more embodiments of the present disclosure.

Further, it will be appreciated by one skilled in the art, aspects of the present disclosure may be illustrated and described herein in any of a number of patentable classes or context including any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof. Accordingly, aspects of the present disclosure may be implemented entirely hardware, entirely software (including firmware, resident software, micro-code, etc. ) or combining software and hardware implementation that may all generally be referred to herein as a “module, ” “unit, ” “component, ” “device, ” or “system. ” Furthermore, aspects of the present disclosure may take the form of a computer program product embodied in one or more computer-readable medium having computer readable program code embodied thereon.

Furthermore, the recited order of processing elements or sequences, or the use of numbers, letters, or other designations, therefore, is not intended to limit the claimed processes and methods to any order except as may be specified in the claims. Although the above disclosure discusses through various examples what is currently considered to be a variety of useful embodiments of the disclosure, it is to be understood that such detail is solely for that purpose and that the appended claims are not limited to the disclosed embodiments, but, on the contrary, are intended to cover modifications and equivalent arrangements that are within the spirit and scope of the disclosed embodiments. For example, although the implementation of various components described above may be embodied in a hardware device, it may also be implemented as a software-only solution, e.g., an installation on an existing server or mobile device.

Similarly, it should be appreciated that in the foregoing description of embodiments of the present disclosure, various features are sometimes grouped together in a single embodiment, figure, or description thereof to streamline the disclosure aiding in the understanding of one or more of the various embodiments. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim. Rather, claim subject matter lie in less than all features of a single foregoing disclosed embodiment.

Claims

A delivery pipe of a tissue clamping device, comprising an outer pipe, an inner core, and a traction mechanism; wherein

the outer pipe is sleeved outside the inner core;

the outer pipe includes a first pipe body and a second pipe body, one end of the first pipe body being connected to the tissue clamping device, another end of the first pipe body being connected to the second pipe body;

the traction mechanism is configured to control the first pipe body to bend.
The delivery pipe of the tissue clamping device of claim 1, wherein one side of the first pipe body is equipped with a plurality of first notches along a length direction of the first pipe body, the first pipe body being able to bend to an opening direction of the plurality of first notches.
The delivery pipe of the tissue clamping device of claim 2, wherein opening sizes of the plurality of first notches are the same or unidentical.
The delivery pipe of the tissue clamping device of claim 3, wherein an opening size of a first notch close to the one end of the first pipe body is less than an opening size of a first notch close to the another end of the first pipe body.
The delivery pipe of the tissue clamping device of claim 2, wherein the first pipe body is integrally formed by cutting a shape memory alloy pipe.
The delivery pipe of the tissue clamping device of claim 1, wherein the traction mechanism includes a first traction filament, one end of the first traction filament being fixedly connected to one end of the first pipe body;

one side of the inner core is equipped with a groove in a length direction of the inner core, the first traction filament being disposed in the groove.
The delivery pipe of the tissue clamping device of claim 6, wherein the traction mechanism further includes a spring tube, the spring tube being sleeved on a portion of the first traction filament corresponding to the second pipe body.
The delivery pipe of the tissue clamping device of claim 7, wherein the traction mechanism further includes a blocking member, the blocking member being sleeved on the first traction filament and fixed at a connection of the first pipe body and the second pipe body to block the spring tube.
The delivery pipe of the tissue clamping device of claim 8, wherein the connection of the first pipe body and the second pipe body is equipped with a connection member, the blocking member being fixedly connected to the connection member.
The delivery pipe of the tissue clamping device of claim 1, wherein the one end of the first pipe body is connected to the tissue clamping device through a delivery connection member.
The delivery pipe of the tissue clamping device of claim 1, wherein the inner core is equipped with a through hole through which a control rod and/or a control cable of the tissue clamping device pass.
The delivery pipe of the tissue clamping device of claim 1, wherein the second pipe body has a mesh woven structure.
The delivery pipe of the tissue clamping device of claim 1, wherein a material layer of polyether block polyamide is disposed on an outer surface of the outer pipe.
A tissue repair device, wherein the tissue repair device includes the delivery pipe of the tissue clamping device of any one of claims 1 to 13.
The tissue repair device of claim 14, wherein the tissue repair device includes a first control handle, the first control handle including a delivery pipe control mechanism, the delivery pipe control mechanism being configured to control the first pipe body of the delivery pipe to bend.
The tissue repair device of claim 14, wherein the tissue repair device further includes a guide pipe, the guide pipe including a bend structure and at least two second traction filaments, the bend structure including a third pipe body and a fourth pipe body, one end of the third pipe body being connected to the fourth pipe body;

the at least two second traction filaments pass through the third pipe body and the fourth pipe body along length directions of the third pipe body and the fourth pipe body, one end of each of the at least two second traction filaments being fixed to another end of the third pipe body; wherein

the at least two second traction filaments are able to be tensioned, respectively, to control the third pipe body to bend to different directions.
The tissue repair device of claim 16, wherein the at least two second traction filaments include two second traction filaments located in a radial direction of the bend structure at both ends of the bend structure, respectively, and wherein

when one of the two second traction filaments is tensioned, another of the two second traction filaments is relaxed.
The tissue repair device of claim 16, wherein the tissue repair device includes a second control handle, the second control handle including a housing and a guide pipe control assembly disposed within the housing, the guide pipe control assembly being configured to control the at least two second traction filaments of the guide pipe to be tensioned respectively, to control the third pipe body of the bend structure of the guide pipe to bend to different directions.
The tissue repair device of claim 18, wherein a count of the at least two second traction filaments is two;

one end of the fourth pipe body of the bend structure of the guide pipe away from the third pipe body is fixed to the housing;

the guide pipe control assembly includes a threaded sleeve, a first traction component, and a second traction component, one end of the two second traction filaments away from a fixing ring being connected to the first traction component and the second traction component, respectively, the threaded sleeve being equipped with a first thread and a second thread, a rotation direction of the first thread being opposite to a rotation direction of the second thread, the first traction component being connected to the threaded sleeve through coordination with the first thread, the second traction component being connected to the threaded sleeve through coordination with the second thread; wherein

when the threaded sleeve is rotated, the first traction component and the second traction component are able to move in opposite directions along a length direction of the threaded sleeve to make one of the two second traction filaments be tensioned and another of the two second traction filaments be relaxed.
The tissue repair device of claim 19, wherein the first thread and the second thread are internal threads located on an inner wall of the threaded sleeve, the first traction component and the second traction component being disposed in the threaded sleeve;

the first traction component includes a first accommodation groove, and the second traction component includes a second accommodating groove, the first accommodation groove and the second accommodation groove being disposed oppositely, and a portion of the guide pipe being able to be accommodated in the first accommodation groove and the second accommodation groove.
A guide pipe, comprising a bend structure and at least two second traction filaments, the bend structure including a third pipe body and a fourth pipe body, one end of the third pipe body being connected to the fourth pipe body;

the at least two second traction filaments pass through the third pipe body and the fourth pipe body along length directions of the third pipe body and the fourth pipe body, one end of each of the at least two second traction filaments being fixed to another end of the third pipe body; wherein

the at least two second traction filaments are able to be tensioned, respectively, to control the third pipe body to bend to different directions.
The guide pipe of claim 21, wherein the at least two second traction filaments includes two second traction filaments located in a radial direction of the bend structure at both ends of the bend structure, respectively, and wherein

when one of the two second traction filaments is tensioned, another of the two second traction filaments is relaxed.
The guide pipe of claim 21, wherein the bend structure further includes a fixing ring, the fixing ring being connected to the another end of the third pipe body, the one end of each of the plurality of second traction filaments being fixed to the fixing ring.
The guide pipe of claim 23, wherein the guide pipe further includes an outer layer structure and an inner layer structure, the outer layer structure, the bend structure, and the inner layer structure being disposed along a radial direction of the guide pipe from outside to inside.
The guide pipe of claim 24, wherein a mounting hole is disposed on the fixing ring, the mounting hole being configured to fix the inner layer structure and/or the outer layer structure.
The guide pipe of claim 21, wherein the third pipe body includes a first sub-pipe body formed by spiral winding of a first wire strip and a second sub-pipe body woven from a second wire strip, the second sub-pipe body being sleeved outside the first sub- tube body.
The guide pipe of claim 26, wherein the fourth pipe body is woven from the second wire strip, the second sub-pipe body and the fourth pipe body being an integral structure.
The guide pipe of claim 26, wherein the first wire strip includes a first sub-wire strip and a second sub-wire strip, the first sub-wire strip and the second sub-wire strip being alternate and spiral winding, a cross-section of the first sub-wire strip being of a rectangular shape, a rectangular shape having a chamfer, or an irregular shape having parallel edges, a cross-section of the second sub-wire strip having an arc contour.
The guide pipe of claim 21, wherein the third pipe body is equipped with a plurality of second notches along a length direction of the third pipe body, opening directions of two adjacent second notches being different.
The guide pipe of claim 29, wherein the third pipe body is integrally formed by cutting a metal tube, and the fourth pipe body is woven from a third wire strip, a connection ring being disposed between the third pipe body and the fourth pipe body.
A tissue repair device, wherein the tissue repair device includes the guide pipe of any one of claims 21 to 30.
The tissue repair device of claim 31, wherein the tissue repair device includes a second control handle, the second control handle including a housing and a guide pipe control assembly disposed within the housing, the guide pipe control assembly being configured to control the at least two second traction filaments of the guide pipe to be tensioned respectively, to control the third pipe body of the bend structure of the guide pipe to bend to different directions.
The tissue repair device of claim 32, wherein a count of the at least two second traction filaments is two;

one end of the fourth pipe body of the bend structure of the guide pipe away from the third pipe body is fixed to the housing;

the guide pipe control assembly includes a threaded sleeve, a first traction component, and a second traction component, one end of the two second traction filaments away from a fixing ring being connected to the first traction component and the second traction component, respectively, the threaded sleeve being equipped with a first thread and a second thread, a rotation direction of the first thread being opposite to a rotation direction of the second thread, the first traction component being connected to the threaded sleeve through coordination with the first thread, the second traction component being connected to the threaded sleeve through coordination with the second thread; wherein

when the threaded sleeve is rotated, the first traction component and the second traction component are able to move in opposite directions along a length direction of the threaded sleeve to make one of the two second traction filaments be tensioned and another of the two second traction filaments be relaxed.
The tissue repair device of claim 33, wherein the first thread and the second thread are internal threads located on an inner wall of the threaded sleeve, the first traction component and the second traction component being disposed in the threaded sleeve;

the first traction component includes a first accommodation groove, and the second traction component includes a second accommodating groove, the first accommodation groove and the second accommodation groove being disposed oppositely, and a portion of the guide pipe being able to be accommodated in the first accommodation groove and the second accommodation groove.
The tissue repair device of claim 34, wherein the second control handle further includes a bending indicator assembly;

the bending indicator assembly including an external thread disposed on an outer wall of the threaded sleeve, a position indicating mechanism connected to the threaded sleeve in coordination with the external thread, and an indication identifier disposed on the housing;

the position indicating mechanism being able to move along the length direction of the threaded sleeve when the threaded sleeve rotates.