WO2021224614A1 - Capillaire - Google Patents

Capillaire Download PDF

Info

Publication number
WO2021224614A1
WO2021224614A1 PCT/GB2021/051081 GB2021051081W WO2021224614A1 WO 2021224614 A1 WO2021224614 A1 WO 2021224614A1 GB 2021051081 W GB2021051081 W GB 2021051081W WO 2021224614 A1 WO2021224614 A1 WO 2021224614A1
Authority
WO
WIPO (PCT)
Prior art keywords
capillary
retention zone
sample retention
sample
main body
Prior art date
Application number
PCT/GB2021/051081
Other languages
English (en)
Inventor
Arvind RANGAN
Carl Chen
Nicola LUMLEY
David DOUCE
Original Assignee
Micromass Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass Uk Ltd filed Critical Micromass Uk Ltd
Publication of WO2021224614A1 publication Critical patent/WO2021224614A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Definitions

  • the present invention relates to a capillary for holding a sample. Background of the invention
  • the invention generally relates to an atmospheric solids analysis probe (ASAP).
  • ASAP atmospheric solids analysis probe
  • Such probes and the associated instrument for use with ASAP are provided by several manufacturers, including Waters Corporation, Milford, MA, U.S.A.
  • ASAP is a useful and relatively cheap tool for use in the direct analysis of volatile and semi-volatile, solid and liquid samples and may be used in the analysis of speciality chemicals, synthetic polymers, energy sources and food.
  • a sample is introduced into an ion source housing (e.g. an API source), in which the sample is volatilised using a heated gas, such as nitrogen, and the sample is then ionised using, for example, a corona discharge pin.
  • a heated gas such as nitrogen
  • the ionised sample may subsequently be analysed in a mass spectrometer.
  • the sample is introduced into the source by loading it onto the tip of a capillary.
  • a capillary may be used multiple times. It is beneficial if the capillary does not degrade over time and/or after multiple cycles.
  • a sample may be loaded onto the distal end of the capillary in various ways, including by dipping the capillary into a sample, or by transferring a sample to the distal end of the capillary, for example by using a pipette.
  • a holder comprising a clamp mechanism which serves to retain the proximal end of the capillary (opposite the tip at the distal end which carries a sample) in the capillary holder. This may provide a user with a more robust method of handling the capillary, and may also assist in the guiding of the capillary into the source.
  • the capillary holder, and/or the source instrument may comprise a guide mechanism to ensure the correct alignment of the capillary as it is loaded into the source.
  • the distal end of the capillary (with sample) is arranged adjacent the outlet of a nozzle for directing heated gas onto the capillary.
  • the distal end of the capillary tip may be difficult to achieve the desired positional accuracy of the distal end of the capillary tip relative to the outlet of the heater. This may be due to tolerance stack-up of the various mechanical arrangements of the ASAP assembly (e.g. the clamp, the guide mechanism and/or the ion source housing). Even if the capillaries used are of substantially the same length, the position of the distal end of one capillary relative to the outlet of the heater may differ to the position of another capillary relative to the outlet of the heater.
  • the sample may spread over the surface of the capillary.
  • the surface of the capillary may provide a wicking function (dependent upon the diluent surface tension) which spreads the sample along the capillary. Consequently, if the sample spreads from the location of the capillary at which it was loaded, there may be ineffective volatilisation of the sample into the gas phase and/or ionisation
  • the present invention provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, at least a part of the sample retention zone comprising a coating.
  • the coating has a different appearance to the main body of the capillary, to visually indicate the location of the sample retention zone to a user.
  • the coating extends substantially around the circumference of the capillary.
  • the sample retention zone extends from a distal end of the capillary for a predetermined axial length.
  • the capillary is substantially cylindrical. In at least one embodiment, the coating is substantially heat resistant.
  • the coating is chemically inert.
  • the coating is is hydrophobic (depending upon the analyte(s) being analysed.
  • the coating is hydrophilic (depending upon the analyte(s) being analysed.
  • the coating is a non-retentive coating.
  • the coating is selected from a group including ceramic, hydride, metal nitride, silicon, silicate, carbide and diamond-like carbon (DLC).
  • DLC diamond-like carbon
  • the coating comprises a sorbent material.
  • At least a portion of the capillary is provided with a sample retention zone and at least a part of the sample retention zone is etched.
  • the sample retention zone is etched substantially around the circumference of the capillary.
  • the sample retention zone extends from a distal end of the capillary for a predetermined axial length.
  • the sample retention zone and/or main body is/are substantially cylindrical.
  • the present invention further provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, wherein at least a part of the or a edge of the sample retention zone comprises a channel, extending around at least a part of the circumference of the capillary.
  • the channel extends substantially around the circumference of the capillary.
  • the sample retention zone extends from a distal end of the capillary for a predetermined axial length.
  • the sample retention zone and/or main body is/are substantially cylindrical.
  • the present invention further provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone having a cross section which is different to a cross section of the main body of the capillary.
  • the main body is substantially cylindrical and the sample retention zone is non-cylindrical.
  • the cross section of the sample retention zone is substantially uniform along the axial length of the sample retention zone.
  • the sample retention zone comprises a concave surface.
  • the present invention further provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone comprising a plurality of depressions and/or protrusions.
  • the sample retention zone comprises a plurality of circumferential grooves.
  • the plurality of circumferential grooves are substantially uniformly distributed along the axial length of the sample retention zone.
  • the sample retention zone comprises a plurality of axial grooves.
  • the plurality of axial grooves are substantially uniformly distributed around the circumference of the sample retention zone.
  • the diameter of the sample retention zone is smaller than the diameter of the main body of the capillary.
  • the surface of the capillary is chamfered at the intersection of the main body and sample retention zone.
  • the sample retention zone and/or main body is/are substantially cylindrical.
  • the present invention further provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, the main body of the capillary having a first diameter, and the sample retention zone having a second diameter, wherein the first diameter is different to the second diameter.
  • the second diameter is smaller than the first diameter.
  • the surface of the capillary is chamfered at the intersection of the main body and sample retention zone.
  • the sample retention zone and/or main body is/are substantially cylindrical.
  • the present invention further provides a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone comprising at least one depression for receiving a sample therein.
  • the depression is substantially concave.
  • the depression is spaced from a distal end of the capillary.
  • the sample retention zone and/or main body is/are substantially cylindrical.
  • the capillary is glass.
  • the capillary comprises borosilicate glass.
  • the capillary is metal.
  • the metal comprises stainless steel, or a stainless steel alloy.
  • the metal comprises aluminum, or an aluminum alloy.
  • the capillary is substantially solid.
  • the capillary comprises a bore.
  • Figure 1 illustrates a capillary embodying the present invention
  • Figure 2 illustrates a capillary according to a first embodiment of the present invention
  • Figure 3 illustrates a capillary according to a second embodiment of the present invention
  • Figure 4 illustrates a capillary according to a third embodiment of the present invention
  • Figure 5 illustrates a capillary according to a fourth embodiment of the present invention
  • Figure 6 illustrates a capillary according to a fifth embodiment of the present invention
  • Figure 7 illustrates a capillary according to a sixth embodiment of the present invention.
  • Figure 8 illustrates a capillary according to a seventh embodiment of the present invention
  • FIG. 1 illustrates a capillary 1 embodying the present invention.
  • the capillary 1 is for holding a sample.
  • the capillary 1 comprises a main body 2, having a first end 3 and a second end 4, opposite the first end 3.
  • the capillary 1 further comprises a sample retention zone 5.
  • the sample retention zone extends from the distal end 3 of the capillary 1 for a predetermined axial length.
  • the axial length of the sample retention zone 5 may be, for example, a tenth of the overall axial length of the capillary 1.
  • the axial length, either absolute or relative to the capillary, of the sample retention zone is not essential.
  • Figure 2 illustrates a capillary 100 according to a first embodiment of the present invention. At least a portion of the capillary 100 is provided with a sample retention zone 105, and at least a part of the sample retention zone 105 comprises a coating 106.
  • the coating 106 has a different appearance to the main body 102 of the capillary, to visually indicate the location of the sample retention zone 105 to a user.
  • the coating 106 extends substantially around the circumference of the capillary 100. This is not essential. In other embodiments, the coating 106 may extend around less than the circumference of the capillary 100. For example, the coating 106 may extend around half of the circumference of the capillary 100.
  • the sample retention zone 105 extends from a distal end 3 of the capillary for a predetermined axial length.
  • the capillary 100 is substantially cylindrical.
  • the coating 106 may be substantially heat resistant.
  • the coating 106 may be hydrophobic or hydrophilic.
  • a hydrophobic coating is a nonpolar material which repels waters and causes sample on the coating to bead into droplets.
  • a hydrophillic coating is a polar material which attracts water, causing a sample to spread across the coated surface. The extent of hydrophobicity or hydrophilicity may be configured depending on the requirements of the user.
  • the surface tension characteristics of a coating on a capillary may have a tendency to change over time, after repeated use.
  • a coating that may be hydrophobic initially may become less hydrophobic and more hydrophilic over time.
  • a sample may then spread out across the coating more easily/readily upon application. This could potentially contribute towards non-repeatability in measurement.
  • the coating is chosen such that the surface tension characteristics (i.e. the extent of hydrophobicity or hydrophilicity) remain substantially constant over time, after repeated use.
  • the coating 106 may be chemically inert.
  • a chemically inert coating may not have any reaction with the sample either at room temperature or at elevated temperatures.
  • the coating is not damaged/released from the surface causing reduced function and/or causing a background within the source environment through ionisation.
  • the coating 105 is a non-retentive coating.
  • the coating may be selected from a group including ceramic, hydride, metal nitride, silicon, silicate, carbide and diamond-like carbon (DLC).
  • the coating may comprise any of those disclosed in US8785843, US8471198 or US10428967, the contents of which are incorporated herein in their entirety.
  • the coating may alternatively comprise SilcoNert (RTM), manufactured by SilcoTek, PA, USA.
  • a coating of a capillary embodying the present invention may serve to prevent, or substantially reduce, adsorption of the sample to the surface, ensuring better distribution of the sample across the sample.
  • the coating may comprise a sorbent material, which may promote the adhesion of one or more selected compounds in a sample applied to the sample retention zone, while releasing one or more other selected compounds for analysis when the capillary is heated in use.
  • the sorbent may be one adopted for chromatographic media.
  • the sorbent may be selected from a group containing alumina, silica, or surface treated silicas with specific end groups such as C2, C8, C18 amide, amine etc.
  • the sorbent material may be stable at high temperatures.
  • the sample retention zone 105 and/or main body 102 is/are substantially cylindrical.
  • the capillary 100 illustrated in Figure 2 may be beneficial in that when a sample is added to the sample retention zone 105, the sample may be substantially retained within the sample retention zone, which may prevent spreading/wicking of the sample outside of the sample retention zone 105, for example up the main body 102 of the capillary 100.
  • a capillary for holding a sample, wherein at least a portion of the capillary is provided with a sample retention zone, wherein at least a part of the sample retention zone is etched.
  • the sample retention zone is etched substantially around the circumference of the capillary.
  • the sample retention zone extends from a distal end of the capillary for a predetermined axial length.
  • the sample retention zone is etched circumferentially, which may aid solvent wetting and movement of the sample to the underside of the capillary tip. This may promote the reproducibility of the distribution of a sample across the sample retention zone, which may be of particular use when a sample is applied to the capillary tip using a pipette (thus relying on the sample being wicked around the circumferential surface of the tip.
  • substantially all of the tip surface may be etched, to increase surface area and improve sample loading. This may improve sample loading when sample is applied to the capillary tip by dipping the tip into a vial of sample.
  • the sample retention zone may be both etched and coated with any of the coatings described herein.
  • Figure 3 illustrates a capillary 200 according to a second embodiment of the present invention. At least a portion of the capillary 200 is provided with a sample retention zone 205. At least a part of the or a edge 206 of the sample retention zone 205 comprises a channel 207, extending around at least a part of the circumference of the capillary 200. The channel 207 may extend substantially around the circumference of the capillary 200.
  • the sample retention zone 205 extends from a distal end 3 of the capillary 200 for a predetermined axial length.
  • the sample retention zone 205 and/or main body 202 is/are substantially cylindrical.
  • the channel 207 extends substantially around the circumference of the capillary 200, this is not essential. In other embodiments, the channel 207 may extend around only some of the circumference of the capillary 200. Although in the embodiment shown there is a single channel 207, in other embodiments of the present invention there may be provided a plurality of channels 207, which may be axially distributed.
  • a benefit of the channel 207 is that is presents a break line in the surface of the capillary 200, so as to reduce or prevent the spreading/wicking of a sample in the sample retention zone 205 up the main body 202 of the capillary 200.
  • Figure 4 illustrates a capillary 300 according to a third embodiment of the present invention. At least a portion of the capillary 300 is provided with a sample retention zone 305.
  • the sample retention zone 305 has a cross- section which is different to a cross-section of the main body 302 of the capillary 300.
  • the main body 302 is substantially cylindrical and the sample retention zone 305 is substantially non-cylindrical.
  • the cross- section of the sample retention zone 305 may be substantially uniform along the axial length of the sample retention zone 305.
  • the sample retention zone 305 comprises a concave surface 306, which effectively provides a spatula for receiving a sample thereon.
  • Figures 5 and 6 illustrate a capillary 400, 500 for holding a sample according to a fourth embodiment of the present invention. At least a portion of the capillary 400, 500 is provided with a sample retention zone 405, 505.
  • the sample retention zone 405, 505 comprises a plurality of depressions 406, 506 and/or protrusions 407, 507.
  • the sample retention zone 405 comprises a plurality of circumferential grooves 406.
  • the plurality of circumferential grooves 406 effectively creates a plurality of corresponding circumferential ridges 407. Consequently, the cross-section of the sample retention zone 405 is non-uniform along the axial length of the sample retention zone 405.
  • the circumferential grooves 406 may be substantially uniformly distributed along the axial length of the sample retention zone 405. Flowever, as shown in the embodiment in Figure 5, this is not essential. The circumferential grooves 406 may be provided along only a part of the axial length of the sample retention zone 405.
  • the sample retention zone 505 comprises a plurality of axial grooves 506. Consequently, a series of corresponding axial ridges 507 are created.
  • the axial grooves 506 may be substantially uniformly distributed around the circumference of the sample retention zone 505. In the embodiment shown, there are six axial grooves 506.
  • the diameter of the sample retention zone 405, 505 is smaller than the diameter of the main body 402, 502 of the capillary 400, 500.
  • the surface 408, 508 at the intersection of the main body 402, 502 and sample retention zone 405, 505, may be chamfered, so as to provide a smooth transition between the sample retention zone 405, 505 and the main body 402, 502. This provides a visual indication to the user of where the end of the sample retention zone 405, 505 is. This may aid a user when dipping the capillary 400, 500 into a sample, so that the user knows how far the capillary 400, 500 must be dipped into a sample.
  • the sample retention zone 405, 505 and/or main body 402, 502 is/are substantially cylindrical.
  • the sample retention zone may comprise a plurality of axial and circumferential grooves, and/or grooves which are at an angle to the longitudinal axis of the capillary.
  • the sample retention zone may be knurled.
  • Figure 7 illustrates a capillary 600 according to a sixth embodiment of the present invention. At least a portion of the capillary 600 is provided with a sample retention zone 605.
  • the main body of the capillary 602 has a first diameter and the sample retention zone 605 has a second diameter.
  • the first diameter is different to the second diameter.
  • the second diameter is smaller than the first diameter, such that the sample retention zone 605 has a smaller diameter than that of the main body 602.
  • the surface 608 at the intersection of the main body 602 and sample retention zone 605 may be chamfered.
  • the sample retention zone 605 and/or main body 602 is/are substantially cylindrical. A benefit of the differing diameters of the sample retention zone 605 and main body 602 is that it provides a visual indicator to a user of the extent of the sample retention zone 605.
  • the sample retention zone 605 may additionally be provided with a coating, such as that used with the capillary 100 illustrated and described in relation to Figure 2.
  • the sample retention zone 605 may further comprise the depressions and/or protrusions as illustrated in and described with reference to Figures 5 and 6.
  • Figure 8 illustrates a capillary 700 according to a seventh embodiment of the present invention. At least a portion of the capillary 700 is provided with a sample retention zone 705.
  • the sample retention zone 705 comprises at least one depression 706 for receiving a sample therein.
  • the depression 706 may be substantially concave.
  • the extent of concavity of the depression 706 in one axis may be different to the extent of concavity of the depression 706 in a different axis.
  • the sample retention zone 705 and/or main body 702 is/are substantially cylindrical.
  • the depression 706 provides a target to the user for adding a sample to the capillary 700. Moreover, the depression 706 may be sized so as to receive a predetermined amount of sample therein. The size of the depression 706 may therefore aid the user in ensuring that the correct volume of sample is added to the depression 706. When adding a sample to the depression 706, a user may observe that the surface tension causes the sample to create a bead within the depression 706.
  • any of the capillaries disclosed herein may be comprised of glass.
  • the glass may be borosilicate glass.
  • the capillary may be comprised of metal.
  • the metal may comprise stainless steel, or a stainless steel alloy.
  • the metal may comprise aluminium, or an aluminium alloy.
  • a capillary embodying the present invention may be substantially solid.
  • the capillary may comprise an axial bore, such as shown in Figures 2 and 3.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, at least a part of the sample retention zone comprising a coating.
  • a capillary according to clause 1 wherein the coating has a different appearance to the main body of the capillary, to visually indicate the location of the sample retention zone to a user.
  • the coating is selected from a group including ceramic, hydride, metal nitride, silicon, silicate, carbide and diamond-like carbon (DLC).
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone and at least a part of the sample retention zone is etched.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, wherein at least a part of the or a edge of the sample retention zone comprises a channel, extending around at least a part of the circumference of the capillary.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone having a cross section which is different to a cross section of the main body of the capillary.
  • a capillary according to clause 21 wherein the main body is substantially cylindrical and the sample retention zone is non-cylindrical.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone comprising a plurality of depressions and/or protrusions.
  • a capillary according to clause 25 wherein the sample retention zone comprises a plurality of circumferential grooves.
  • 27 A capillary according to clause 24, wherein the plurality of circumferential grooves are substantially uniformly distributed along the axial length of the sample retention zone.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, the main body of the capillary having a first diameter, and the sample retention zone having a second diameter, wherein the first diameter is different to the second diameter.
  • a capillary according to clause 33 wherein the second diameter is smaller than the first diameter.
  • 35 A capillary according to any of clauses 33 and 34, wherein the surface of the capillary is chamfered at the intersection of the main body and sample retention zone.
  • a capillary for holding a sample wherein at least a portion of the capillary is provided with a sample retention zone, the sample retention zone comprising at least one depression for receiving a sample therein.
  • a capillary according to clause 41 wherein the capillary comprises borosilicate glass.
  • a capillary according to clause 43 wherein the metal comprises stainless steel, or a stainless steel alloy.
  • the metal comprises aluminum, or an aluminum alloy.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un capillaire destiné à contenir un échantillon, au moins une partie du capillaire étant pourvue d'une zone de rétention d'échantillon, au moins une partie de la zone de rétention d'échantillon comprenant un revêtement.
PCT/GB2021/051081 2020-05-05 2021-05-05 Capillaire WO2021224614A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10202004138S 2020-05-05
SG10202004138S 2020-05-05

Publications (1)

Publication Number Publication Date
WO2021224614A1 true WO2021224614A1 (fr) 2021-11-11

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PCT/GB2021/051081 WO2021224614A1 (fr) 2020-05-05 2021-05-05 Capillaire

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Country Link
WO (1) WO2021224614A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128460A1 (de) * 2001-06-12 2003-01-02 Michael Licht Vorrichtung und Verfahren zum Sammeln von kleinen wässrigen Flüssigkeitsproben
WO2011071353A2 (fr) * 2009-12-07 2011-06-16 Jeon Min-Yong Tube pour centrifugeuse
US8471198B2 (en) 2009-05-13 2013-06-25 Micromass Uk Limited Mass spectrometer sampling cone with coating
US10428967B2 (en) 2011-04-25 2019-10-01 Waters Technologies Corporation Valves having protective coatings

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128460A1 (de) * 2001-06-12 2003-01-02 Michael Licht Vorrichtung und Verfahren zum Sammeln von kleinen wässrigen Flüssigkeitsproben
US8471198B2 (en) 2009-05-13 2013-06-25 Micromass Uk Limited Mass spectrometer sampling cone with coating
US8785843B2 (en) 2009-05-13 2014-07-22 Micromass Uk Limited Mass spectrometer sampling cone with coating
WO2011071353A2 (fr) * 2009-12-07 2011-06-16 Jeon Min-Yong Tube pour centrifugeuse
US10428967B2 (en) 2011-04-25 2019-10-01 Waters Technologies Corporation Valves having protective coatings

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