WO2021219360A1 - Compressed tablet comprising l-theanine - Google Patents
Compressed tablet comprising l-theanine Download PDFInfo
- Publication number
- WO2021219360A1 WO2021219360A1 PCT/EP2021/059500 EP2021059500W WO2021219360A1 WO 2021219360 A1 WO2021219360 A1 WO 2021219360A1 EP 2021059500 W EP2021059500 W EP 2021059500W WO 2021219360 A1 WO2021219360 A1 WO 2021219360A1
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- WO
- WIPO (PCT)
- Prior art keywords
- compressed tablet
- tablet
- total weight
- compressed
- vitamin
- Prior art date
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- 239000007891 compressed tablet Substances 0.000 title claims abstract description 267
- DATAGRPVKZEWHA-UHFFFAOYSA-N l-theanine Chemical compound CCNC(=O)CCC(N)C(O)=O DATAGRPVKZEWHA-UHFFFAOYSA-N 0.000 title claims abstract description 25
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims abstract description 49
- 229930003231 vitamin Natural products 0.000 claims description 27
- 235000013343 vitamin Nutrition 0.000 claims description 27
- 239000011782 vitamin Substances 0.000 claims description 27
- 229940088594 vitamin Drugs 0.000 claims description 27
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 18
- 239000004615 ingredient Substances 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 229940119217 chamomile extract Drugs 0.000 claims description 9
- 235000020221 chamomile extract Nutrition 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 239000000796 flavoring agent Substances 0.000 claims description 8
- 235000019634 flavors Nutrition 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 239000007888 film coating Substances 0.000 claims description 5
- 238000009501 film coating Methods 0.000 claims description 5
- 235000003599 food sweetener Nutrition 0.000 claims description 5
- 239000000314 lubricant Substances 0.000 claims description 5
- 239000003765 sweetening agent Substances 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- 229930003448 Vitamin K Natural products 0.000 claims description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
- -1 dilutents Substances 0.000 claims description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 3
- 238000009495 sugar coating Methods 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000005282 vitamin D3 Nutrition 0.000 claims description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 3
- 239000011647 vitamin D3 Substances 0.000 claims description 3
- 235000019168 vitamin K Nutrition 0.000 claims description 3
- 239000011712 vitamin K Substances 0.000 claims description 3
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- 229940021056 vitamin d3 Drugs 0.000 claims description 3
- 229940046010 vitamin k Drugs 0.000 claims description 3
- 235000019156 vitamin B Nutrition 0.000 claims description 2
- 239000011720 vitamin B Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 17
- 238000009472 formulation Methods 0.000 abstract description 10
- 235000015218 chewing gum Nutrition 0.000 abstract description 8
- 229940112822 chewing gum Drugs 0.000 abstract description 6
- 239000003826 tablet Substances 0.000 description 16
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 3
- 239000008116 calcium stearate Substances 0.000 description 3
- 235000013539 calcium stearate Nutrition 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 2
- 235000006468 Thea sinensis Nutrition 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 230000036626 alertness Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
Definitions
- the present invention relates to a new formulation containing L-theanine.
- the formulation of the present invention is a compressed tablet, which is also a chewing gum.
- the chewing gum of the present invention comprises L-theanine and also optionally some Chamomile extract.
- L-Theanine is a unique amino acid found naturally in the tea plant (Camellia sinensis). Among other positive propertied, L-Theanine promotes relaxation while maintaining alert ness and promotes healthy cognitive function. L-Theanine may also support healthy vas cular function through this relaxing effect.
- L-theanine A unique property of L-theanine is that is promotes relaxation without drowsiness.
- L-theanine has poor compressibility. To deliver L-theanine in tablet format often faces challenges such as capping and low tablet hardness.
- L-theanine tablets have either lower L-theanine claim such as 100 mg and high serving size (2 tablets).
- L-theanine capsules commercially available but the 2-piece capsule shell is often relatively large and not very easy for a consumer to swallow.
- Camomile extract is oily upon compression in a regular tablet formulation. This causes some problems such as sticking.
- the compressed tablet which is also a chewing gum, has none of the disadvantages.
- the compressed tablet of the present invention is chewed and while chewing the healthy ingredients (next to L-theanine, other ingredients may also be incorporated into the new formulation) are released in the mouth and the conveyed into the gut system.
- the tablet is not swallowed and after a certain time (when the healthy ingredients have been re leased) the rest of the tablet (mainly the gum base) can be spit out (like a regular chewing gum).
- the present invention relates to a novel confectionery, which is a compressed tablet (CT), comprising
- a suitable compressed tablet has usually a total weight of 0.5 - 5 grams (preferably 1 - 5g).
- the present invention relates to a compressed tablet (CT1), which is a com pressed tablet (CT), wherein the compressed tablet has a total weight of 0.5 - 5 g.
- the shape of the compressed tablets according to the present invention is not so essen tial. It can have usually used shape for tablets (disc-like, cubes, spheres or any other shape).
- the compressed tablet according to the present invention comprises 3- 12 wt- %, based on the total weight of the compressed tablet, of L-theanine.
- the compressed tablet according to the present invention comprises 4 - 10 wt-%, based on the total weight of the compressed tablet, of L-theanine.
- the present invention relates to a compressed tablet (CT2), which is a com pressed tablet (CT) or (CT1), wherein the compressed tablet comprises 3 - 12 wt-%, based on the total weight of the compressed tablet, of L-theanine.
- the present invention relates to a compressed tablet (CT2’), which is a com pressed tablet (CT) or (CT1), wherein the compressed tablet comprises 4 - 10 wt-%, based on the total weight of the compressed tablet, of L-theanine.
- the compressed tablet according to the present invention comprises 0.5 - 3 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
- the compressed tablet according to the present invention comprises 0.8
- the present invention relates to a compressed tablet (CT3), which is a com pressed tablet (CT), (CT1), (CT2) or (CT2’), wherein the compressed tablet comprises 0.5
- the present invention relates to a compressed tablet (CT3’), which is a com pressed tablet (CT), (CT1), (CT2) or (CT2’), wherein the compressed tablet comprises 0.8
- the compressed tablet is a chewing gum, therefore an essential ingredient of the com pressed tablet according to the present invention is a gum base.
- a gum base is well known ingredient in commonly known chewing gums.
- Such gum bases are commercially available.
- resin, wax, and elastomer are usually three main components make up all gum bases: resin, wax, and elastomer.
- Resin ex. terpene
- Wax softens the gum.
- Elas tomers add flexibility.
- the molecular composition of a gum base is very similar to that of plastics and rubbers.
- gum bases are available commercially, for example from companies such as Cafosa or Gum Base Co.
- the compressed tablet according to the present invention comprises 55 - 80 wt-%, based on the total weight of the compressed tablet, of a gum base.
- the compressed tablet according to the present invention comprises 55 - 70 wt-%, based on the total weight of the compressed tablet, of a gum base.
- the present invention relates to a compressed tablet (CT4), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3) or (CT3’), wherein the compressed tablet comprises 55 - 80 wt-%, based on the total weight of the compressed tablet, of a gum base.
- the present invention relates to a compressed tablet (CT4’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3) or (CT3’), wherein the compressed tablet comprises 55 - 70 wt-%, based on the total weight of the compressed tablet, of a gum base.
- CT4 com pressed tablet
- CT1 com pressed tablet
- CT2 CT2
- CT3 CT3
- Vitamins used in the compressed tablet according to the present invention can be water-soluble Vitamins (such as Vitamin C and B complex Vitamins) and/or fat-soluble Vitamins (such as Vitamin E, D3, A, K).
- the compressed tablets according to the present invention comprises at least one water-soluble Vitamin and at least one fat-soluble Vitamin.
- the water-soluble Vitamins are chosen from the group consisting of Vit amin C, and B complex Vitamins. More preferably, the fat-soluble Vitamins are chosen from the group consisting of Vitamin E, and Vitamin A, Vitamin D3, and Vitamin K.
- the present invention relates to a compressed tablet (CT5), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4) or (CT4’), wherein the compressed tablet comprises at least one water-soluble Vitamin and at least one fat-sol uble Vitamin.
- the present invention relates to a compressed tablet (CT5’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4) or (CT4’), wherein the compressed tablet comprises at least one water-soluble Vitamin chosen from the group consisting of Vitamin C, B complex Vitamins and at least one fat-soluble Vitamin chosen from the group consisting of Vitamin E, Vitamin A, Vitamin D3, and Vitamin K.
- the compressed tablet according to the present invention comprises 0.2 - 6 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
- the compressed tablet according to the present invention comprises 0.8 - 4 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
- the present invention relates to a compressed tablet (CT6), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5) or (CT5’), wherein the compressed tablet comprises 0.2 - 6 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
- the present invention relates to a compressed tablet (CT6’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5) or (CT5’), wherein the compressed tablet comprises 0.8 - 4 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
- CT6 compressed tablet
- Such ingredients are sweeteners, flavors, dilutents, and lubricants.
- ingredients are present in a compressed tablet according to the present invention in an amount of up to 60 wt-%, based on the total weight of the com pressed tablet.
- the compressed tablet according to the present invention comprises 10 - 35 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary com pound.
- the compressed tablet according to the present invention comprises 15 - 30 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
- the present invention relates to a compressed tablet (CT7), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6) or (CT6’), wherein the compressed tablet comprises 10 - 35 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
- the present invention relates to a compressed tablet (CT7’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6) or (CT6’), wherein the compressed tablet comprises 15 - 30 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
- the auxiliary compounds used in the compressed tablet according to the pre sent invention chosen from the group consisting of sweeteners, flavors, diluents, and lub ricants.
- the present invention relates to a compressed tablet (CT8), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6), (CT6’), (CT7) or (CT7’), wherein the at least one auxiliary compound is chosen from the group consisting of sweeteners, flavors, diluents, and lubricants.
- the compressed tablet according to the present invention can be coated.
- Such a coating is usually a film coating or a sugar coating.
- the amount of coating in rela tion to the core is small.
- the present invention relates to a compressed tablet (CT9), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6), (CT6’), (CT7), (CT7’) or (CT8), wherein the compressed tablet according to the present invention is coated.
- CT9 a compressed tablet
- CT9 is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6), (CT6’), (CT7), (CT7’) or (CT8), wherein the compressed tablet according to the present invention is coated.
- the present invention relates to a compressed tablet (CT9’), which is a com pressed tablet (CT9), wherein the coating is a film coating or a sugar coating.
- Such coating materials are available commercially.
- film coating material such as Nutrafinish ® available from Colorcon.
- ingredients can be any commonly used ingredients in such coatings (such as dyestuffs, flavors, sweeteners).
- the compressed tablets are produced by using commonly known methods.
- a general way to produce the compressed tablets according to the present invention is the following:
- step 1 Use appropriate amount of water, and add step 1 to water to make 20% dispersion (solid content 20% w/w) with low shear mixing for at least 40 minutes.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Physiology (AREA)
- Alternative & Traditional Medicine (AREA)
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Abstract
The present invention relates to a new formulation containing L-theanine. The formulation of the present invention is a compressed tablet, which is also a chewing gum.
Description
Compressed Tablet Comprising L-Theanine
The present invention relates to a new formulation containing L-theanine. The formulation of the present invention is a compressed tablet, which is also a chewing gum.
The chewing gum of the present invention comprises L-theanine and also optionally some Chamomile extract.
L-Theanine is a unique amino acid found naturally in the tea plant (Camellia sinensis). Among other positive propertied, L-Theanine promotes relaxation while maintaining alert ness and promotes healthy cognitive function. L-Theanine may also support healthy vas cular function through this relaxing effect.
A unique property of L-theanine is that is promotes relaxation without drowsiness.
L-theanine has poor compressibility. To deliver L-theanine in tablet format often faces challenges such as capping and low tablet hardness.
Therefore, many L-theanine tablets have either lower L-theanine claim such as 100 mg and high serving size (2 tablets).
There are also L-theanine capsules commercially available but the 2-piece capsule shell is often relatively large and not very easy for a consumer to swallow.
Another problem of formulations comprising Chamomile extract is that Camomile extract is oily upon compression in a regular tablet formulation. This causes some problems such as sticking.
Due to the great properties of L-theanine, there is always beneficial to provide improved formulation comprising L-theanine. These new and improved formulations do not have the disadvantages of the prior art.
It is surprising that it was possible to compress L-theanine and optionally Chamomile ex tract in a tablet with the aid of gum powder. The tablet was further coated at relatively low temperature to achieve better physical appearance.
The compressed tablet, which is also a chewing gum, has none of the disadvantages.
The compressed tablet of the present invention is chewed and while chewing the healthy ingredients (next to L-theanine, other ingredients may also be incorporated into the new formulation) are released in the mouth and the conveyed into the gut system. The tablet is not swallowed and after a certain time (when the healthy ingredients have been re leased) the rest of the tablet (mainly the gum base) can be spit out (like a regular chewing gum).
Therefore, the present invention relates to a novel confectionery, which is a compressed tablet (CT), comprising
(i) 2 - 15 weight-% (wt-%), based on the total weight of the compressed tablet, of L-theanine, and
(ii) up to 5 wt-%, based on the total weight of the compressed tablet, of Chamomile extract, and
(iii) 20 - 90 wt-%, based on the total weight of the compressed tablet, of a gum base, and
(iv) up to 30 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin (fat and/or water soluble), and
(v) up to 70 wt-%, based on the total weight of the compressed tablet, of any other ingredient (auxiliary compound) usually used in a compressed (chewable) tab let.
It is obvious that all the ingredients of a compressed tablet according to the present inven tion are always adding up to 100%.
A suitable compressed tablet has usually a total weight of 0.5 - 5 grams (preferably 1 - 5g).
Therefore, the present invention relates to a compressed tablet (CT1), which is a com pressed tablet (CT), wherein the compressed tablet has a total weight of 0.5 - 5 g.
The shape of the compressed tablets according to the present invention is not so essen tial. It can have usually used shape for tablets (disc-like, cubes, spheres or any other shape).
Preferably, the compressed tablet according to the present invention comprises 3- 12 wt- %, based on the total weight of the compressed tablet, of L-theanine.
More preferably, the compressed tablet according to the present invention comprises 4 - 10 wt-%, based on the total weight of the compressed tablet, of L-theanine.
Therefore, the present invention relates to a compressed tablet (CT2), which is a com pressed tablet (CT) or (CT1), wherein the compressed tablet comprises 3 - 12 wt-%, based on the total weight of the compressed tablet, of L-theanine.
Therefore, the present invention relates to a compressed tablet (CT2’), which is a com pressed tablet (CT) or (CT1), wherein the compressed tablet comprises 4 - 10 wt-%, based on the total weight of the compressed tablet, of L-theanine.
Preferably, the compressed tablet according to the present invention comprises 0.5 - 3 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
More preferably, the compressed tablet according to the present invention comprises 0.8
- 2.5 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
Therefore, the present invention relates to a compressed tablet (CT3), which is a com pressed tablet (CT), (CT1), (CT2) or (CT2’), wherein the compressed tablet comprises 0.5
- 3 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
Therefore, the present invention relates to a compressed tablet (CT3’), which is a com pressed tablet (CT), (CT1), (CT2) or (CT2’), wherein the compressed tablet comprises 0.8
- 2.5 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
The compressed tablet is a chewing gum, therefore an essential ingredient of the com pressed tablet according to the present invention is a gum base. Such a gum base is well known ingredient in commonly known chewing gums. Such gum bases are commercially available.
Usually, formulations of gum bases are considered proprietary information for industry competitors. But usually three main components make up all gum bases: resin, wax, and elastomer. Resin (ex. terpene) is the main chewable portion. Wax softens the gum. Elas tomers add flexibility. The molecular composition of a gum base is very similar to that of plastics and rubbers.
As said such gum bases are available commercially, for example from companies such as Cafosa or Gum Base Co.
Preferably, the compressed tablet according to the present invention comprises 55 - 80 wt-%, based on the total weight of the compressed tablet, of a gum base.
More preferably, the compressed tablet according to the present invention comprises 55 - 70 wt-%, based on the total weight of the compressed tablet, of a gum base.
Therefore, the present invention relates to a compressed tablet (CT4), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3) or (CT3’), wherein the compressed tablet comprises 55 - 80 wt-%, based on the total weight of the compressed tablet, of a gum base.
Therefore, the present invention relates to a compressed tablet (CT4’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3) or (CT3’), wherein the compressed tablet comprises 55 - 70 wt-%, based on the total weight of the compressed tablet, of a gum base.
As stated above, the Vitamins used in the compressed tablet according to the present invention can be water-soluble Vitamins (such as Vitamin C and B complex Vitamins) and/or fat-soluble Vitamins (such as Vitamin E, D3, A, K).
Preferably, the compressed tablets according to the present invention comprises at least one water-soluble Vitamin and at least one fat-soluble Vitamin.
More preferably, the water-soluble Vitamins are chosen from the group consisting of Vit amin C, and B complex Vitamins.
More preferably, the fat-soluble Vitamins are chosen from the group consisting of Vitamin E, and Vitamin A, Vitamin D3, and Vitamin K.
Therefore, the present invention relates to a compressed tablet (CT5), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4) or (CT4’), wherein the compressed tablet comprises at least one water-soluble Vitamin and at least one fat-sol uble Vitamin.
Therefore, the present invention relates to a compressed tablet (CT5’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4) or (CT4’), wherein the compressed tablet comprises at least one water-soluble Vitamin chosen from the group consisting of Vitamin C, B complex Vitamins and at least one fat-soluble Vitamin chosen from the group consisting of Vitamin E, Vitamin A, Vitamin D3, and Vitamin K.
Preferably, the compressed tablet according to the present invention comprises 0.2 - 6 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
More preferably, the compressed tablet according to the present invention comprises 0.8 - 4 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
Therefore, the present invention relates to a compressed tablet (CT6), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5) or (CT5’), wherein the compressed tablet comprises 0.2 - 6 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
Therefore, the present invention relates to a compressed tablet (CT6’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5) or (CT5’), wherein the compressed tablet comprises 0.8 - 4 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
The compressed tablet according to the present invention can comprise any further ingre dient, which are commonly used such compressed tablets (chewing gums) according to the present invention.
Such ingredients (auxiliary compounds) are sweeteners, flavors, dilutents, and lubricants.
As stated above such ingredients are present in a compressed tablet according to the present invention in an amount of up to 60 wt-%, based on the total weight of the com pressed tablet.
Preferably the compressed tablet according to the present invention comprises 10 - 35 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary com pound.
More preferably the compressed tablet according to the present invention comprises 15 - 30 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
Therefore, the present invention relates to a compressed tablet (CT7), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6) or (CT6’), wherein the compressed tablet comprises 10 - 35 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
Therefore, the present invention relates to a compressed tablet (CT7’), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6) or (CT6’), wherein the compressed tablet comprises 15 - 30 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
Preferably, the auxiliary compounds used in the compressed tablet according to the pre sent invention chosen from the group consisting of sweeteners, flavors, diluents, and lub ricants.
Therefore, the present invention relates to a compressed tablet (CT8), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’),
(CT6), (CT6’), (CT7) or (CT7’), wherein the at least one auxiliary compound is chosen from the group consisting of sweeteners, flavors, diluents, and lubricants.
Optionally, the compressed tablet according to the present invention can be coated.
Such a coating is usually a film coating or a sugar coating. The amount of coating in rela tion to the core is small.
Therefore, the present invention relates to a compressed tablet (CT9), which is a com pressed tablet (CT), (CT1), (CT2), (CT2’), (CT3), (CT3’), (CT4), (CT4’), (CT5), (CT5’), (CT6), (CT6’), (CT7), (CT7’) or (CT8), wherein the compressed tablet according to the present invention is coated.
Therefore, the present invention relates to a compressed tablet (CT9’), which is a com pressed tablet (CT9), wherein the coating is a film coating or a sugar coating.
Such coating materials are available commercially. For example film coating material such as Nutrafinish ® available from Colorcon.
It is also possible to add other ingredients to the coating. Such ingredients can be any commonly used ingredients in such coatings (such as dyestuffs, flavors, sweeteners).
The compressed tablets are produced by using commonly known methods.
A general way to produce the compressed tablets according to the present invention is the following:
First, mix L-Theanine, Camomile extract, gum base, and other diluents for 10 to 15 mins in a V-shaped blender without chopping.
Then add flavors and sweetners and mix for 1 to 5 mins. Add sieved lubricant (through a 20-40 mesh screen), mix for up to 5 mins. Compress tablets using a rotary press (pressure up to 45 kN).
The following examples serve to illustrate the invention.
Examples Example 1
Table 1. Formulation of core tablets
Core tablets procedures:
1. Weigh all ingredients in appropriate containers.
2. Pass all solid ingredients except Calcium Stearate through a #16 mesh sieve.
3. Add sorbitol to Hobart mixer, then add liquid flavor to mix for 5 minutes at low speed. Pass through #16 mesh again.
4. Mix all solid ingredients except Calcium Stearate for 20 mins in a V blender. If any lumps are seen, pass through 16 mesh sieve again.
5. Pass Calcium Stearate through #40 mesh sieve. Add to step 4 and mix for another 2 minutes.
6. Compress tablets on a “D” rotary press using round 0.8125” standard con cave toolings. Compression force: 6000 LBs. Press speed: 55 rpm
Table 2. Coating compositions
Coating procedures:
1. Weigh 100 g of Nutrafinish 131 U 180003 White, 100g of Nutrafinish 132U 190008 Clear, 1 g of sucralose, 3.5 g of strawberry flavor, and 0.02 g of FDC Red 40 lake. Mix them in a poly bag for 5 minutes.
2. Use appropriate amount of water, and add step 1 to water to make 20% dispersion (solid content 20% w/w) with low shear mixing for at least 40 minutes.
3. Weigh 900 g of core tablets and place into the coating pan.
4. Tumble the tablets in the pan coater and pump coating dispersion using a Masterflex pump. Perform film coating with the following parameters: atomization pressure- 2 bar; pattern air- 0.5 bar; product temperature NMT (not more than) 38.5 °C; pan speed: 25 rpm; spray rate: NMT 3.5 g/min; target weight gain- 6%.
Claims
1. A compressed tablet comprising
(i) 2 - 15 weight- % (wt-%), based on the total weight of the compressed tablet, of L- theanine, and
(ii) up to 5 wt-%, based on the total weight of the compressed tablet, of Chamomile extract, and
(iii) 20 - 90 wt-%, based on the total weight of the compressed tablet, of a gum base, and
(iv) up to 30 wt-%, based on the total weight of the compressed tablet, of at least one
Vitamin (fat and/or water soluble), and
(v) up to 70 wt-%, based on the total weight of the compressed tablet, of any other ingredient (auxiliary compound) usually used in a compressed tablet.
2. Compressed tablet according to claim 1 , wherein the compressed tablet has a total weight of 0.5 - 5 g.
3. Compressed tablet according to claim 1 or claim 2, wherein the compressed tablet comprises 3 - 12 wt-%, based on the total weight of the compressed tablet, of L-theanine.
4. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises 0.5 - 3 wt-%, based on the total weight of the compressed tablet, of Chamomile extract.
5. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises 55 - 80 wt-%, based on the total weight of the compressed tablet, of a gum base.
6. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises at least one water-soluble Vitamin and at least one fat-soluble Vitamin.
7. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises at least one water-soluble Vitamin chosen from the group con sisting of Vitamin C and B complex Vitamins and at least one fat-soluble Vitamin chosen from the group consisting of Vitamin E, Vitamin A, Vitamin D3, and Vitamin K.
8. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises 0.2 - 6 wt-%, based on the total weight of the compressed tablet, of at least one Vitamin.
9. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet comprises 1 - 50 wt-%, based on the total weight of the compressed tablet, of at least one auxiliary compound.
10. Compressed tablet according to anyone of the preceding claims, wherein the at least one auxiliary compound is chosen from the group consisting of sweeteners, flavors, dilutents, and lubricants.
11. Compressed tablet according to anyone of the preceding claims, wherein the com pressed tablet according to the present invention is coated.
12. Compressed tablet according to claim 11 , wherein the coating is a film coating or sugar coating.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063015833P | 2020-04-27 | 2020-04-27 | |
| US63/015,833 | 2020-04-27 |
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| Publication Number | Publication Date |
|---|---|
| WO2021219360A1 true WO2021219360A1 (en) | 2021-11-04 |
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ID=75539320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2021/059500 WO2021219360A1 (en) | 2020-04-27 | 2021-04-13 | Compressed tablet comprising l-theanine |
Country Status (1)
| Country | Link |
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| WO (1) | WO2021219360A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115708820A (en) * | 2023-01-09 | 2023-02-24 | 广东科泰鼎润药业科技有限公司 | L-theanine sustained release preparation, double-release preparation, application and medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1743634A1 (en) * | 2004-05-06 | 2007-01-17 | Taiyokagaku Co., Ltd. | Alcohol metabolism accelerating composition, and food or drink containing the composition |
| US20120121520A1 (en) * | 2010-11-16 | 2012-05-17 | Jon Barron | Functional formulation in chewing gum |
-
2021
- 2021-04-13 WO PCT/EP2021/059500 patent/WO2021219360A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1743634A1 (en) * | 2004-05-06 | 2007-01-17 | Taiyokagaku Co., Ltd. | Alcohol metabolism accelerating composition, and food or drink containing the composition |
| US20120121520A1 (en) * | 2010-11-16 | 2012-05-17 | Jon Barron | Functional formulation in chewing gum |
Non-Patent Citations (1)
| Title |
|---|
| ANONYMOUS: "Amazon.com: OLLY Sleep Melatonin Gummy, All Natural Flavor and Colors with L Theanine, Chamomile, and Lemon Balm, 3 mg per Serving, 25 Day Supply (50 Count): Health & Personal Care", 15 April 2018 (2018-04-15), XP055822186, Retrieved from the Internet <URL:https://www.amazon.com/Supplement-Melatonin-L-Theanine-Chamomile-Blackberry/dp/B0145QI7O0?th=1> [retrieved on 20210707] * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115708820A (en) * | 2023-01-09 | 2023-02-24 | 广东科泰鼎润药业科技有限公司 | L-theanine sustained release preparation, double-release preparation, application and medicine |
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