WO2021207517A3 - Modified hr2 peptide inhibitors of coronavirus fusion - Google Patents
Modified hr2 peptide inhibitors of coronavirus fusion Download PDFInfo
- Publication number
- WO2021207517A3 WO2021207517A3 PCT/US2021/026416 US2021026416W WO2021207517A3 WO 2021207517 A3 WO2021207517 A3 WO 2021207517A3 US 2021026416 W US2021026416 W US 2021026416W WO 2021207517 A3 WO2021207517 A3 WO 2021207517A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- modified
- fusion
- peptide inhibitors
- peptides
- coronavirus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Abstract
Provided are modified HR2 peptides that are capable of competing with the native HR2 region of a viral spike (S) protein for binding to the HR1 region, thereby inhibiting formation of the 6-HB fusion complex and fusion with a target host cell, compositions comprising the modified HR2 peptides, and methods of inhibiting viral fusion using the HR2 peptides.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063008469P | 2020-04-10 | 2020-04-10 | |
US63/008,469 | 2020-04-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021207517A2 WO2021207517A2 (en) | 2021-10-14 |
WO2021207517A3 true WO2021207517A3 (en) | 2022-01-06 |
Family
ID=78023205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2021/026416 WO2021207517A2 (en) | 2020-04-10 | 2021-04-08 | Modified hr2 peptide inhibitors of coronavirus fusion |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2021207517A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023150375A2 (en) * | 2022-02-07 | 2023-08-10 | Decoy Therapeutics Inc. | Methods and compositions for treating covid infections |
WO2023159113A1 (en) * | 2022-02-16 | 2023-08-24 | Greene Warner C | Peptide fusion inhibitors exhibiting pan-coronavirus inhibitory activity |
CN115746148B (en) * | 2022-10-14 | 2023-09-12 | 中国医学科学院病原生物学研究所 | Proteins with coronavirus RBD and membrane fusion inhibiting polypeptides and their use as coronavirus inhibitors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053728A2 (en) * | 2000-12-29 | 2002-07-11 | Elitra Pharmaceuticals, Inc. | Gene disruption methodologies for drug target discovery |
US20160237123A1 (en) * | 2008-01-23 | 2016-08-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of viral infections |
-
2021
- 2021-04-08 WO PCT/US2021/026416 patent/WO2021207517A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053728A2 (en) * | 2000-12-29 | 2002-07-11 | Elitra Pharmaceuticals, Inc. | Gene disruption methodologies for drug target discovery |
US20160237123A1 (en) * | 2008-01-23 | 2016-08-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of viral infections |
Also Published As
Publication number | Publication date |
---|---|
WO2021207517A2 (en) | 2021-10-14 |
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