WO2021205208A1 - Dispositif de normalisation de l'expression génique de cellules humaines et d'affaiblissement de l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques - Google Patents

Dispositif de normalisation de l'expression génique de cellules humaines et d'affaiblissement de l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques Download PDF

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Publication number
WO2021205208A1
WO2021205208A1 PCT/IB2020/053348 IB2020053348W WO2021205208A1 WO 2021205208 A1 WO2021205208 A1 WO 2021205208A1 IB 2020053348 W IB2020053348 W IB 2020053348W WO 2021205208 A1 WO2021205208 A1 WO 2021205208A1
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WO
WIPO (PCT)
Prior art keywords
electromagnetic
bed
support
gene expression
coil
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Application number
PCT/IB2020/053348
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English (en)
Inventor
Ali HASHEMI
Original Assignee
Hashemi Ali
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hashemi Ali filed Critical Hashemi Ali
Priority to PCT/IB2020/053348 priority Critical patent/WO2021205208A1/fr
Publication of WO2021205208A1 publication Critical patent/WO2021205208A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/06—Magnetotherapy using magnetic fields produced by permanent magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/12—Magnetotherapy using variable magnetic fields obtained by mechanical movement

Definitions

  • the present invention relates to medical machines and equipment and specially relates to electromagnetic waves generating and radiating device and also relates to structures and systems to control the power, frequency, direction and concentration of waves radiation and also relates to the way the wave generation generator move and circulate, controlling the amount of emission of waves or magnetic and electromagnetic waves.
  • the immune system is part of the body that identifies its own cells and molecules from aliens such as germs and viruses, destroys or defuses them.
  • the body destroys the pathogenic and alien factors with two ways of dedicated or non-dedicated defense, defuses them and prevents from disease.
  • the non- dedicated defense works the same against most germs and cannot identify different germs from each other.
  • the non-dedicated defense includes the first line and the second line of the defense. On the first line of defense, horny layers (Stratum corneum) of surface of skin that made from keratin, prevents from penetration of germs to the body. Furthermore, skin fat and sweat make the surface of skin acidic and prevent from growth of germs.
  • the enzyme "Lysozyme” contains in tear, sweat, mucosal fluid and saliva causes destruction of bacteria's cell wall.
  • the mucosal layers by releasing mucus containing mucin and water, create a glutinous and gloppy liquid which contains lysozyme. This concentrated liquid trapes germs and bacteria.
  • the respiratory tract from nose to nostrils, the surface of the gastrointestinal tract from mouth to the anus, and the urinary tract from the bladder to the urethra and the inner surface of genital tract have a covering tissue called mucosal layer.
  • the gastrointestinal tract by releasing gastric acid cause destruction of germs and by defection cause expulsion of the germs.
  • the white blood cells are the most important parts of the second line of non-dedicated defense. Phagocytes from white blood cells swallow, decompose and disintegrate the germs by phagocytosis. At first the germs are surrounded by false leg and then enter to globule as vesicle. Also there, the lysozyme enzymes decompose them.
  • the gene expression is a process in which information within the gene is used to make a functional product.
  • Gene products are mainly amino acids and the non amino acid products include rRNA, tRNA and snRNA. Different steps can be taken for the gene expression process which generally involves transcription, RNA binding, translation and post translational modifications of a protein.
  • Gene expressions allow the cell to control its structure and function and it is the basis cellular differentiation (distinction), transformation (evolution) and the ability to adopt organisms to the new conditions.
  • sunspots are the phenomena of the visible surface of the sun which are darker than other parts; the darkest part is the central area of all spots. Although most small spots and apertures disintegrate very quickly, but some of them become real massive spots. The largest dark spot is 30000 km in diameter of shadow and the diameter of penumbra area is more than twice of this amount. Therefore these spots can sometimes be detected by the naked eye at sunset when the sun is pale.
  • Each spot is made of two parts. A center part that is dark and the other is around the spot that is lighter than the center.
  • each spot on the sun's surface is temporary and gradually fades away with the extent of activity. The way it disappears is that the light around the spot gradually encircles its core (center) and approaches the center and completely destroys the dark area.
  • the creation of enormous magnetic loop between the more glowing parts of the sun with these parts results in intense magnetic radiation.
  • the most important feature of the sunspot is its magnetic field and this is why the sunspot is cooler than its surroundings.
  • a sunspot has a magnetic polarity which collects spots on both sides of the magnetic pole but there may be exceptions where the second magnet area is scattered and only one sunspot is seen.
  • the graph of the increase and decrease in the number of spots and their size is a kind of pulse or sinusoidal curve that reaches to its peak almost every 10 and 11 years.
  • the inducer energy source is electromagnetic energy.
  • the electromagnetic energy may be a component of visible light having a wavelength in the range of 450 nm-700 nm.
  • the component of visible light may have a wavelength in the range of 450 nm-500 nm and may be blue light.
  • the blue light may have an intensity of at least 0.2 mW/cm2, or more preferably at least 4 mW/cm2.
  • the component of visible light may have a wavelength in the range of 620-700 nm and is red light.
  • US6424864B1 patent number named Method and apparatus for wave therapy by Masayuki Matsuura in Japan is mentioned to the system and method of treatment with electromagnetic waves.
  • EP2676700A2 patent number provides a chair equipped with coil for electromagnetic radiation to correct problems of pelvis muscles.
  • Pulsed magnetic field (PMF) treatments are receiving growing interest as a therapeutic approach for several neuronal diseases. Although the exact mechanism of action of PMF treatments is unknown, reported findings represent a promising alternative therapeutic choice for the management of neuropathic pain. PMF treatments can supply new strategies for the therapy of life-threatening neuropathic pain due to its antihyper glycemic, anti inflammatory, antihyperalgesic, antiallodynic, and neuroimmunomodulatory actions. In this review, they summarized the several recent findings about antineuropathic actions of PMF treatment in experimental animals with neuropathic pain induced by disease and/or damage.
  • PEMF therapy modulates gene expression and protein synthesis interacting with specific DNA sequences within gene promoter regions
  • PEMFs inhibit angiogenesis in tumor tissues, suppressing tumor vascularization and reducing tumor growth, as shown by in vivo studies.
  • the specific claim, supported by, described in vivo studies, is that all treated groups showed slower tumor growth rate if compared with untreated control group, confirming that PEMF therapy can modulate the physiology and electrochemistry of cancer cells and influence cell membrane systems and mitosis.
  • PEMFs induce some changes in membrane transport capacity through impacting the osmotic potential, ionic valves and leading to reduction in cellular stress factors, increase in the rate of DNA transcription, and modulation of immune response.
  • PEMFs have also an immunomodulatory effect, as supported by in vivo evidence showing an increase in tumor necrosis factor alpha levels that induce an anti-tumoral response, leading to the activation of a proapoptotic pathway induced by caspase-8 interaction with Fas-associated death domain, in the spleen of the murine melanoma mouse model after a 16-day therapy.
  • Changes in blood pressure, skin electrical resistance, and pulse amplitude in oncology patients exposed to tumor- specific PEMF frequencies have also been reported suggesting that PEMF therapy does not only target neoplastic cells, but may also have systemic effects.
  • the influence of the magnetic field on the ionic balance of the cell membrane surface can affect the membrane inlet valves, reducing or increasing the rate of entry and exit of the material. This effect can also alter the expression of genes in different part of the body, including changes in the expression of genes present in bacteria and viruses.
  • the 1st consisted of 16 patients with COPD who were treated by PETh and pharmacologically.
  • the 2nd group consisted of 24 patients with COPD who were treated only with medicaments.
  • the 3rd group consisted of 37 asthmatics, treated by PETh and medicaments.
  • the 4th group consisted of 40 asthmatics treated only with medicaments.
  • the effectiveness of PETh was assessed by lung function tests, which were performed using a Spirometer 100 Handi (Germany). They measured FYCex, FEY1, percentage of FEVl/FVCex, MEF25, 50, 75, PEF and registered the flow-volume loops. PETh was applied by apparatus MTU 500H (Therapy System, Czech Republic).
  • PETh was very effective in patients with COPD.
  • the measured indexes improved about 200-660 ml or ml x s(-l), except FVC.
  • PETh was less effective in asthmatics. Most indices improved without statistical significance, about 50-620 ml or ml x s(-l).
  • the indices of FEV1/FVC and MEF25 deteriorated. The changes in controls without PETh were very small.
  • the present invention is a medical device and equipment which contains different parts.
  • the first part of the device is a body structure consisting of a large cast iron plate which is show in figure 1, part 111 and also a vertical support more than 2 meters long as shown in figure 1, part 101.
  • Vertical support can be mounted on the horizontal plate and the vertical support is responsible for handling and maintaining the main equipment of invention.
  • There is a hydraulic jack inside vertical support which can be shortened and lifted in a vertical direction. Given to the fact that there is a need of operator for the treatment, and according to the treatment protocol defined by the physician, the height of the vertical support is fixed, but the hydraulic jack inside the support is conversional. By changing the height of the jack, the meeting point of device bed to the vertical support shown in figure 1, part 102 can be changed.
  • the mechanism of increasing and decreasing the length of the hydraulic jack inside the vertical support is a common mechanism that instead of hydraulic jack, pneumatic jack can be used; also this length change can be done with the use of Rack structure or Lead Screw structure.
  • the purpose of designing and installing vertical support is simply to change the height of device and to facilitate the use of device.
  • the angle of bed and patient relative to the horizontal line using motor and gearbox which generally the worm gear is the best type of gearbox for this purpose.
  • the operator after regulating the height of device can change the angle of bed depend on the type of treatment protocol.
  • the device can be positioned vertically and the patient standing upright as well as the device positioned horizontally and the patient lying down.
  • Bed angle changes toward the vertical and base support of device will be done with the help of operator through the issuance of controlling orders.
  • On the hydraulic jack structure or height gain equipment of the device can prevent from entering the dust to the vertical base of the device or prevent from egressing of contamination from mechanical structures of the device to the medical part using the louvered structure shown in figure 1, part 103.
  • the body of the device or the body of the bed is mounted on a protruding structure from the vertical base of the device by means of a vertical piece; the angle shifting structure can keep all the equipment moreover the bed support depend on the required angle in balance condition using a hub or cantilever.
  • the angle part of the device and defining the angle of patient bed is shown on figure 1, part 102.
  • the bed itself which is shown in part 107, is mounted perpendicular to the support so by increasing the height of the vertical base, the increase in bed height toward the surface will occur. And also by increasing or decreasing the defined angle of bed support toward the vertical base, the defined angle of patient with the horizontal line will be defined.
  • the patient's bed junctions are divided into two sections, the upper and lower part.
  • the upper part has ergonomic facilities for the patient's body for a long time.
  • patient's standing on the surface in a structure that is perpendicular to the ground is possible by creating a tenacious stair perpendicular to the patient's bed as shown in figure 1, part 113.
  • the patient can initially be prepared for the treatment operation by standing on a special toe pad and sticking to bed surface from the back but if needed the bed height is increased by the operator and the angle of the bed is also changed toward the horizontal line the allow the patient to be positioned horizontally or at any angle toward the horizontal line.
  • holders on the patient's bed that are fixed or holders with the ability to adjust the space which determine the exact location of the patient after placing the patient on the bed and locating the middle holder between two legs of the patients.
  • the operator can first move the two holders to the patient from both side of the knee and fix the patient's leg in the correct place. It can also fix the position of patient's pelvis on the bed by adjusting the middle holder.
  • the haunch part of the patient almost goes on the rest position and fixed on the bed.
  • the bust part of the patient and in particular the patient's skull becomes fixed.
  • the main tools of the device or invention are placed.
  • the main support of movable tools under the bed will be installed to the bed as shown in part 112 of the figure.
  • the head portion of the therapeutic device or probe there is a specific coil with a certain number of copper, aluminum or any other type of metal wire which have varnish coating , that is responsible for creating an electromagnetic field; in the center of this coil, there is a high purity iron core with a non magnetic ability after the power outage, which only at the time of applying magnetic field with the help of Solenoid make the maximum power of the coil and after outage, completely lose its magnetic nature.
  • This coil or bobbin is mounted on an aluminum support that allows to rotate and change magnetic poles of magnet by rotating servomotor connected to the aluminum support.
  • the said coil is connected to a generating magnetic pulse system with the ability to adjust and change.
  • the connection of the said system to the base of the servomotor is done with the help of several moving collectors.
  • connection between the magnet wires and the power supply is done with the help of these rotating collectors without any outage.
  • rotation of the servomotor connected to the support of the electric magnet will not change the transfer of current or pulses in the stream of the electricity sent to the magnet.
  • the connection of the electric power transmission wires to the coil is done via a rotating collector as well as the connection of control and power transmission wire of servomotor. In this way concurrent to rotation of servomotor and coil support, the servomotor axis connected to the Z rail can rotate as well.
  • control and power wires of both servomotors as well as the current transmission wires to the support and magnet bobbin can get into the control box from the side of device.
  • Three servomotors connected to the X, Y and Z rails can create the overall movement of the therapeutic support under or behind the patient's bed with the sightly algorithm and specific conditions of the physician.
  • the function of the device can be defined in this way; the electromagnetic waves is created around an iron core by a copper coil. Given to existence of two aluminum support above and under the said coil, it allows the coil to lock between these two supports.
  • the lower part of the support is connected to a servomotor which given to existence of a rotating collector in the lower part of support, the rotation simultaneously with creation of electromagnetic waves can be possible.
  • the said system is on the housing support and by rotation of the shaft connected to the housing, cause the rotation of servomotor, housing and the said module. Transvers and longitudinal movements and movements in line with height of support holding the housing, is done by three servomotors settled on the rails.
  • the responsibility to control the servomotors and consequently moving the support lies with a computer.
  • the wave shape is created by an oscillator and according to the orders issued by the computer.
  • the intensity and weakness of waves also is created by the amplifier existed in the structure of device and according to the orders issued by the computer.
  • number of electromagnetic waves generation modules can be more than one, and there can be two electromagnetic waves generation modules on the rail which is in line with the body width.
  • the present invention can be used to treat or help to treat viral diseases, metabolic diseases, and diseases with direct relation with microorganisms and also wide range of diseases derived from wrong gene expression including cancers and also used in reduction of side effects including pain or destruction of organisms and their body structures. Also the present invention can be used in regulation of existed structures in the body of living things including regulating the ionic exchanges, genetic and hormonal disorders.
  • a permanent magnet can be used instead of electromagnetic coil.
  • the present invention due to the possibility of adjusting the intensity of magnetic field, the direction of magnetic field, dynamic transmission of waves, changes of wave length and also subaltemation, will allows to create changes in gene expression of diseases such as corona, zika and generally viral diseases family. Thus with the changes made in gene expression, the possibility of propagation and spread of disease is minimized in body, and the body's immune system will have enough time to destroy the aliens and external factors.
  • the magnetic field by making changes in natural gene expression of humans cells cause many other changes includes expression of insulin synthesis, increasing the secretion of insulin, increasing the glucose entrance into the cell, the glucose entrance in to the natural cellular metabolism cycle, increasing the cellular energy, decreasing the acidity of human cells, increasing the power of immune system and as a result indisposing the environment for growth and propagation of virus.
  • the magnetic field made by the said device allows treating disease with metabolic, bacterial, microbial and genetically origins.
  • the present invention includes an electromagnetic module with the ability to rotate around the axis perpendicular to the coil, a rotatable support for mounting an electromagnetic module, a set of servomotors and rails which are perpendicular to each other with the ability to move in space in line with X, Y and Z, a plate with the ability to carry rails and modules to create space for the movement of support, a bed equipped with adjustable holders to fix the patient, a support connected to the bed to keep the patient's bed suspended with the ability to rotate around the center point to create angle in the bed, a vertical base with the ability to adjust the height to keep the bed, support and tools connected to the electromagnetic module suspended, a base that can be mounted on the ground to settle the vertical base, a control box for required electricity, a computer to control the position of bed, electromagnetic module and electromagnetic waves radiation algorithm which its electromagnetic module can create from one or more coils with specific number of turns around an iron core.
  • the electromagnetic coil can be in the form of a cylindrical coil or a coil polygonal cross section and the electromagnetic coil can be defined as a single coil or several crossover coils.
  • the electromagnetic coil is enclosed in an aluminum support.
  • the aluminum support containing an electromagnetic coil is connected to a servomotor to rotate electromagnet.
  • the servomotor carrying electromagnetic module is mounted on a rotatable system and support.
  • the rotatable support is mounted on the moving rail in the Z axis (height).
  • the set of supports and electromagnet's servomotors are mounted on a matrix motion system with the ability to move along length, width and height.
  • the present invention is equipped with a bed having holder to fix the patient.
  • the set of bed and electromagnetic module can mount to a vertical column alongside to itself with the help of a vertical support and its height can change with the column going up and down.
  • the patient's bed support and its connection to the column joint causes the system of bed and supports to have required angle toward to horizon line around this joint
  • the intensity and shape of the wave and the amplitude of oscillation create by the existed software on the computer and then is sent to the electromagnetic wave generation coil after reinforcing in the structure of control box.
  • the present invention can equipped to several systems of rails and motion supports and if necessary all of these moving structures can move one or more electromagnetic waves generation module.
  • Figure 1 shows afront view of the invention which the patient's bed is located horizontally on it.
  • Figure 2 shows the afront view of the invention while the patient's bed is located vertically toward the device.
  • Figure 3 shows the view from the top of the bed in the present invention.
  • Figure 4 shows the multi module device of the said invention.
  • Figure 5 shows the moving housing of electromagnetic waves generation modules.
  • Figure 6 shows the servomotor propellant transmission shaft of housing.
  • Figure 7 shows the base of rotation axis.
  • Figure 8 shows the housing, base and motion shaft.
  • Figure 9 shows the manner of connection of housing, housing holder base and shaft.
  • Figure 10 shows the electromagnetic waves radiation modules included one coil with defined turn around an iron core which is mounted between two aluminum supports on one servomotor.
  • Figure 11 shows the electromagnetic waves generation coil.
  • Figure 12 shows the manner of connection of wave generation module on the servomotor.
  • Figure 13 shows the meeting point of wave generation module and its servomotor on the rotating housing.
  • Figure 14 shows the results of adaptation of spread of epidemic disease time chart on the chart of number of sunspots.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L'invention concerne un dispositif pour normaliser l'expression génique de cellules humaines et affaiblir l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques qui, par la réalisation d'un champ magnétique et la commande de l'intensité, de la direction et de la longueur d'onde au moyen de servomoteurs, de supports et de module de génération d'ondes électromagnétiques, peut réaliser certaines modifications de l'expression génique de virus comme le corona pour empêcher la propagation et la dissémination du virus. En outre, le champ magnétique grâce à la réalisation de certains changements naturels dans l'expression génique de cellules humaines indispose l'environnement contre la propagation et la croissance de virus et, en conséquence, amène le virus à être semi-actif. Ce champ magnétique permet de traiter les maladies ayant des origines métaboliques, bactériennes, microbiennes et génétiques.
PCT/IB2020/053348 2020-04-08 2020-04-08 Dispositif de normalisation de l'expression génique de cellules humaines et d'affaiblissement de l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques WO2021205208A1 (fr)

Priority Applications (1)

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PCT/IB2020/053348 WO2021205208A1 (fr) 2020-04-08 2020-04-08 Dispositif de normalisation de l'expression génique de cellules humaines et d'affaiblissement de l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques

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PCT/IB2020/053348 WO2021205208A1 (fr) 2020-04-08 2020-04-08 Dispositif de normalisation de l'expression génique de cellules humaines et d'affaiblissement de l'expression génique du coronavirus au moyen de champs magnétiques et électromagnétiques

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7644458B2 (en) * 1993-01-21 2010-01-12 Hill-Rom Services, Inc. Hospital bed

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7644458B2 (en) * 1993-01-21 2010-01-12 Hill-Rom Services, Inc. Hospital bed

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHUBERT RAJIB; HERZOG SOPHIE; TRENHOLM STUART; ROSKA BOTOND; MüLLER DANIEL J.: "Magnetically guided virus stamping for the targeted infection of single cells or groups of cells", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 14, no. 11, 18 October 2019 (2019-10-18), GB , pages 3205 - 3219, XP036917367, ISSN: 1754-2189, DOI: 10.1038/s41596-019-0221-z *

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