WO2021202788A3 - Modified oligomeric compounds and uses thereof - Google Patents

Modified oligomeric compounds and uses thereof Download PDF

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Publication number
WO2021202788A3
WO2021202788A3 PCT/US2021/025241 US2021025241W WO2021202788A3 WO 2021202788 A3 WO2021202788 A3 WO 2021202788A3 US 2021025241 W US2021025241 W US 2021025241W WO 2021202788 A3 WO2021202788 A3 WO 2021202788A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligomeric compounds
modified oligomeric
modified
stereo
standard
Prior art date
Application number
PCT/US2021/025241
Other languages
French (fr)
Other versions
WO2021202788A2 (en
Inventor
Michael T. Migawa
Graeme C. FREESTONE
Punit P. Seth
Original Assignee
Ionis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals, Inc. filed Critical Ionis Pharmaceuticals, Inc.
Publication of WO2021202788A2 publication Critical patent/WO2021202788A2/en
Publication of WO2021202788A3 publication Critical patent/WO2021202788A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard 4' -thio nucleoside.
PCT/US2021/025241 2020-04-03 2021-03-31 Modified oligomeric compounds and uses thereof WO2021202788A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063004880P 2020-04-03 2020-04-03
US63/004,880 2020-04-03

Publications (2)

Publication Number Publication Date
WO2021202788A2 WO2021202788A2 (en) 2021-10-07
WO2021202788A3 true WO2021202788A3 (en) 2021-11-11

Family

ID=77929875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/025241 WO2021202788A2 (en) 2020-04-03 2021-03-31 Modified oligomeric compounds and uses thereof

Country Status (1)

Country Link
WO (1) WO2021202788A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939677B2 (en) * 2003-09-18 2011-05-10 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
US20130115272A1 (en) * 2011-10-03 2013-05-09 modeRNA Therapeutics Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20160355536A1 (en) * 2014-02-18 2016-12-08 Fujifilm Corporation Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
WO2019157531A1 (en) * 2018-02-12 2019-08-15 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
US20190263850A1 (en) * 2013-03-14 2019-08-29 Translate Bio, Inc. Ribonucleic acids with 4'-thio-modified nucleotides and related methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7939677B2 (en) * 2003-09-18 2011-05-10 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
US20130115272A1 (en) * 2011-10-03 2013-05-09 modeRNA Therapeutics Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20190263850A1 (en) * 2013-03-14 2019-08-29 Translate Bio, Inc. Ribonucleic acids with 4'-thio-modified nucleotides and related methods
US20160355536A1 (en) * 2014-02-18 2016-12-08 Fujifilm Corporation Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
WO2019157531A1 (en) * 2018-02-12 2019-08-15 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof

Also Published As

Publication number Publication date
WO2021202788A2 (en) 2021-10-07

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