WO2021202788A3 - Modified oligomeric compounds and uses thereof - Google Patents
Modified oligomeric compounds and uses thereof Download PDFInfo
- Publication number
- WO2021202788A3 WO2021202788A3 PCT/US2021/025241 US2021025241W WO2021202788A3 WO 2021202788 A3 WO2021202788 A3 WO 2021202788A3 US 2021025241 W US2021025241 W US 2021025241W WO 2021202788 A3 WO2021202788 A3 WO 2021202788A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligomeric compounds
- modified oligomeric
- modified
- stereo
- standard
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard 4' -thio nucleoside.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063004880P | 2020-04-03 | 2020-04-03 | |
US63/004,880 | 2020-04-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2021202788A2 WO2021202788A2 (en) | 2021-10-07 |
WO2021202788A3 true WO2021202788A3 (en) | 2021-11-11 |
Family
ID=77929875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2021/025241 WO2021202788A2 (en) | 2020-04-03 | 2021-03-31 | Modified oligomeric compounds and uses thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2021202788A2 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939677B2 (en) * | 2003-09-18 | 2011-05-10 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
US20130115272A1 (en) * | 2011-10-03 | 2013-05-09 | modeRNA Therapeutics | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
US20160355536A1 (en) * | 2014-02-18 | 2016-12-08 | Fujifilm Corporation | Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
WO2019157531A1 (en) * | 2018-02-12 | 2019-08-15 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
US20190263850A1 (en) * | 2013-03-14 | 2019-08-29 | Translate Bio, Inc. | Ribonucleic acids with 4'-thio-modified nucleotides and related methods |
-
2021
- 2021-03-31 WO PCT/US2021/025241 patent/WO2021202788A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939677B2 (en) * | 2003-09-18 | 2011-05-10 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
US20130115272A1 (en) * | 2011-10-03 | 2013-05-09 | modeRNA Therapeutics | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
US20190263850A1 (en) * | 2013-03-14 | 2019-08-29 | Translate Bio, Inc. | Ribonucleic acids with 4'-thio-modified nucleotides and related methods |
US20160355536A1 (en) * | 2014-02-18 | 2016-12-08 | Fujifilm Corporation | Method for producing thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
WO2019157531A1 (en) * | 2018-02-12 | 2019-08-15 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2021202788A2 (en) | 2021-10-07 |
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