WO2021181402A1

WO2021181402A1 - Sarva jura kudineer

Info

Publication number: WO2021181402A1
Application number: PCT/IN2020/000017
Authority: WO
Inventors: S.P. Malarkannan; P. Dharumarajan; D. Gayathri
Original assignee: Malarkannan S P; Dharumarajan P; Gayathri D
Priority date: 2020-03-09
Filing date: 2020-07-15
Publication date: 2021-09-16

Abstract

A composition is prepared for the treatment and management of certain types of bacterial and viral diseases like coronavirus (COVID-19), H1N, ZIKA virus, HIV, Hantavirus, Ebola virus etc.comprising ingredients of desired parts of Solanum xanthocarpum, Tinospora cordifolia, Zingiber officinalis, Tragia involucrata, Clerodendrum serratum, Cyperus rotundus, Piper longum, Andrographis paniculata, Mollugo cerviana, and Costus speciosus in the required quantity. The ingredients are boiled under the mild flame for a definite period of time and reduced its volume to a specific quantity. The supernatant liquid hence obtained is filtered and used as a "Kashayam". The Kashayam is antiviral, antibacterial, antiasthmatic, immunostimulant, anti-inflammatory, antipyretic, hepatoprotective, anti-diarrheal, anti-ulcer, antioxidant, anthelmintic, antiplasmodial, a thrombolytic agent, anticancer, anti-poisonous effect, laxative, cardiotonic activity, CNS depressant, antihypertensive, and anti-epileptic activity against diseases of zoonotic importance or communicable diseases that result in infections such as Corona virus (COVID-19) H1N1, ZIKA virus, HIV, Hantavirus, Ebola virus, etc. and provides clarity of mind.

Description

SARVA JURA KUDINEER

FIELD OF THE INVENTION

The proposed invention relates to an herbal extract for reducing pyrexia and treating any disease due to unknown causes of several Viral and bacterial Infections. The development and standardization of the herbal extract ensures the curing of infectious diseases of viral and bacterial origin with following symptoms like cold, cough, rhinitis, sore throat, bronchitis, asthma, sinusitis, headache, fever of various origin, body ache, nausea, vomiting, thirst, loss of appetite, diarrhea, seizures, anaemia, oedema, fatigue, drowsiness, anxiety, giddiness, depression, insomnia, dysuria, liver diseases, cardiac weakness, diabetes and also has antiviral, antibacterial, antiasthmatic, immunostimulant, anti-inflammatory, antipyretic, hepatoprotective, anti-diarrheal, anti-ulcer, antioxidant, anthelmintic, antiplasmodial, a thrombolytic agent, anticancer, anti poisonous effect, laxative, cardiotonic activity, CNS depressant, antihypertensive and anti-epileptic activity against diseases of zoonotic importance or communicable diseases that results in infections such as Coronavirus (COVID-19) H1 N1, ZIKA virus, HIV virus, Hantavirus, Ebola virus etc. and provides clarity of mind.

BACKGROUND OF THE INVENTION

India is rich in indigenous herbal resources consisting of about 20,000 plant species, of which about 2,500 are of medicinal value (Kartikeyan, et.al., 2012). Medicinal plants are generally known as “Chemical Goldmines" as they contain natural chemicals, which are acceptable to human and animal systems. In recent years, ethnobotanical and traditional uses of natural compounds, especially of plant origin received much attention as they are well tested for their efficacy and generally believed to be safe for human use. The Indian subcontinent and Africa have long been recognized as an herbal hub and a variety of herbal medicines in different formulations have been used for several years. All these chemicals cannot be synthesized in laboratories. Many secondary metabolites of the plant are commercially important and find use in a number of pharmaceutical compounds. Human beings have been dependent on plants for their health care needs since the beginning of civilization. Of the 2,50,000 higher plant species on earth, more than 80,000 are medicinal in Nature (Thomas, 1997). Increasing population size, drugs insufficiency, higher cost, severe adverse effects and ineffectiveness of many allopathic drugs, escort to the significance of herbal medicines to combat many diseases (Panda et. al., 2012) however, many plant species are not fully explored.

Solarium xanthocarpum Linn, in India it is known by its various vernacular names, the most commonly used ones are Vanabharata, Kateli (Hindi), Kateli (Urdu), Nellagulla, (Kannad), Cheruvazhuthina, (Malayalam), TellaMulaka (Telugu), Kandlarivaddi (Punjab) (Anonymous, 1999) is used In Ayurveda system of medicine either as a single drug or in combination with other drugs. Seeds, roots, leaves, and berries are useful in various diseases such as bronchitis, asthma, dry cough, rhinitis, dysuria, leucoderma, sexual disorders, insomnia, cardiac weakness and pruritis (Bhakta, 2004; Bhattacharya, 1982).

In Ayurveda, Solanum xanthocarpum is a component of a very popular formulation known as Dashmula recommended for post-natal care to avoid secondary complications. AcharyaCharaka placed the plant into Kanthya (a group of herbs used in throat disorders), Hikkanigrahana (a group of herbs used in treating hiccups), Shothahara (anti-inflammatory group of herbs), AngamardaPrashamana (Pain relieving group of herbs) mahakashayas (Jadavji, 2011). The whole plant of Indian Nightshade is used for cardiac tonic, astringent, carminative, immunomodulatory agent and clinically uses for weakness, nausea and bronchospasm (Sultana et al., 2011), root of Solanum xanthocarpum is used for Aphrodisiac Potentials (Gupta at. al., 2013), anticarcinogens (El-Aasr et.al., 2009) digestive disorder (Sathishpandiyan et. al., 2014)

Sharma et al. (2017) reported that Solanum xanthocarpum has various phytoconstituents like Steroidal saponins, a steroidal glycoside, sesquiterpenoids, hydroxycoumarins, phenolic compounds, coumarins, coumarinolignoids alkaloids, saponin, fatty acid, glycerides of the oil, polysaccharides, triterpenes. The plant was evaluated for a number of activities such as antibacterial, antioxidant, anthelmintic, antiplasmodial, hepatoprotective, anticancer, laxative, cardiotonic activity, CNS depressant, and antihypertensive activity.

Tinospora cordifolia Is commonly known as heart leaved Moonseed Plant (English), Amrita Guduchi (Sanskrit), Giloe (Hindi), Gulancha (Bengali), Giloya (Hindi), Galo (Gujrati) and Teppatige (Telugu), It is large deciduous climbing shrub fourid throughout India, and also in Sri Lanka, Bangladesh and China (Jitendra at al., 2014).

A variety of active components derived from Tinospora cordifolia plant-like alkaloids, steroids, diterpenoid lactones, aliphatics, and glycosides have been isolated from the different parts of the plant body, including root, stem, and whole plant (Soham and Shyamasree, 2012). T. cordifolia medical applications include controlling various disorders and usages as anti-oxidant, antihyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotectlve, radioprotective, anti-anxiety, adaptogenic agent, analgesic, anti- inflammatory, antipyretic, a thrombolytic agent, an anti-diarrheal, anti-ulcer, an antimicrobial and anti-cancer agent. The plant is also a source of micronutrients viz. copper, calcium, phosphorus, iron, zinc, and manganese. A special focus has been made on its health benefits in treating endocrine and metabolic disorders and its potential as an immune booster. Several patents have been filed and granted to inventions encompassing T. cordifolia as a major component of therapeutics for ameliorating metabolic, endocrinal and several other ailments, aiding in the betterment of human life expectancy (Dhama et al., 2012). Tinospora cordifolia has importance in traditional ayurvedic medicine used for ages in the treatment of fever, jaundice, chronic diarrhea, cancer, dysentery, bone fracture, pain, asthma, skin disease, poisonous insect, snake bite, eye disorders (Soham and Shyamasree, 2012).

Tragia involucrata is a shrub, widely distributed in the Indian subcontinent and grows in dry land weed. It is found to have enormous medicinal properties and has been used by the Malayali tribes of Western Ghats of India. The preliminary phytochemical screening results revealed the presence of alkaloids, carbohydrates, protein, tannins, flavonoids, sterois and saponins in the different extracts of T.involucrata analgesic activity of T. involucrata was mediated by the inhibition of prostaglandins sensitized pain receptors .at the inflammatory site (Dhara at. al., 2000), anti-inflammatory, hepatoprotective activity (Alanazi at al., 2015), antibacterial activity against opportunistic pathogens namely E. coli, S. aureus, P.mirabilis, and S. marcescens isolated from clinical cases of suspected symptomatic HIV/AIDS patients. (Xavier et al., 2015), antioxidant property (Gopalakrishnan et al., 2013), wound healing, antidiabetic activity, induced sleep, significant depression of body temperature and suppression of the aggressive behavior pattern and antiepileptic activity (Chaudhuri et. al., 2002)

Zingiber officinale, normally rhizome are used apart from culinary uses, ginger and its major components, are known to have beneficial medicinal properties used in Ayurveda, Siddha, Chinese, Arabian, Africans, Caribbean, and many other medicinal systems and reported to possess essential oils, phenolic compounds, flavonoids, carbohydrates, proteins, alkaloids, glycosides, saponins, steroids, terpenoids and tannin as the major phytochemical groups (Grzanna et al., 2005). Numerous pre- clinical studies have supported their value in the treatment of diabetes, obesity, diarrhoea, allergies, pain, fever, rheumatoid arthritis, inflammation, vomiting, asthma, cough, palpitation, inflammation, dyspepsia, loss of appetite, constipation, indigestion and various forms of cancer. Tumors induced in the bowel, breast, ovaries, pancreas, Liver, CNS and cardiovascular disorders have been effectively treated in animal models with biologically active constituents of ginger. Ginger and its metabolites have been recognized as potent antioxidants due to their ability to inhibit the oxidation of various free radicals and the production of nitric oxide. Gingerol exerts inhibitory effects on the biosynthesis of prostaglandins and leukotrienes through suppression of prostaglandin synthase or 5-lipoxygenase (Kiuchi et.al., 1992).

Clerodendrum serratum is a genus of ca. 500 species in the family Lamiaceae and widely distributed throughout the whole world. Clerodendrum genus has 283 compounds, including monoterpene and its derivatives, sesquiterpene, diterpenoids, triterpenoids, flavonoid and flavonoid glycosides, phenylethanoid glycosides, steroids and steroid glycosides, cyclohexylethanoids, anthraquinones, cyanogenic glycosides, and others have been isolated and identified. Pharmacological studies have shown that these compounds and extracts from the Clerodendrum genus have extensive activities, such as anti-inflammatory and anti-nociceptive, anti-oxidant, anti-hypertensive, anticancer, antimicrobial, anti-diarrheal, hepatoprotective, hypoglycemic and hypolipidemic, memory enhancing and neuroprotective, and other activities. An aqueous extract of roots of Clerodendrum reported having significant anti-inflammatory effects at a high dose (180 mg/kg, p.o.) in the granuloma pouch model in rats. Roots in low dose (90 mg/kg, p.o.) and stems in high dose (180 mg/kg, p.o.) showed significant preventive effects In comparison with dexamethasone (a standard anti-inflammatory agent). Thus, it can be postulated that roots are more effective than stems and it would be useful as an antiallergic and antiinflammatory drug for a disease like asthma (Bhangare et. al., 2012).

Clerodendrum exert has various biological activities, such as anti- inflammatory and anti-nociceptive, antioxidant, anticancer, antimicrobial, anti- hypertensive, anti-obesity, anti-diarrheal, hepatoprotective, memory enhancing, and neuroprotective activities. Terpenes, including monoterpene and its derivatives, sesquiterpene, diterpenoids, triterpenoids, as the major characteristic constituents with significant biological activities, have great potential to be developed into new drugs, especially for anti-inflammatory, antioxidant, anticancer, and antimicrobial agents. In addition, important activities, such as anti-hypertensive, anti-obesity, and hepatoprotective activities indicated that Clerodendrum genus can be a promising source of biologically active compounds for these diseases (Jin-Hui Wang, et. al. , 2018)

Costus speciosus is native to South East Asia, especially the plant that is widely distributed in India in the tropical or sub-tropical climate from the sea level to the Himalayas, excluding the arid and semi-arid areas of Punjab, Haryana, Rajasthan, Gujarat, and peninsular India. The herb 'Kemuka' or 'Kebuka' ( Costus speciosus) have Vernacular names in different parts of India are - Assamese- Kebuk, Devitokan. jomlakhuti, Hindi- Keu, Kemuka, Kemua, Kevuka, Kobee, Kust; Bengali- Kou, Kust, Kemut, Keugachh; Marathi- Penva, Pinnga, Kobee, Pinga, Pushkarmula; Malayalam- Channak-koova. Narum canna, Cannakkuvva, Cannukkilannu, Telegu- Kashmeeramu, kasmiramu, kevukinna, kimuka, koshtamu, bhangalkoshta, bommakaccika, Kannada- Aarathikundige, Benne kundige, Cangalakoshta, Pharsi- Kalaam; TamllKostam, cancamancam, catikostam, Gujrati- Pakarmula.

The rhizomes of Costus speciosus are the major source of diosgenin. The other major chemical constituents are curcumin and curcuminoids, tuners and roots contain 5a-stigmasten-3b-ol, sitosterolβ-D-glucoside, dioscin, prosapogenins A and B of dioscin, gracillin, and quinines. Saponins were also reported from rhizomes, including seeds and roots. Tigogenin and diosgenin (2.6%) have been isolated from rhizomes. Various compounds like α-amyrinsterate, β-amyrin and lupeolPalmitates were isolated from leaves. Two new quinones - dihydro phytyl plastoquinone and its 6-methyl derivatives and a-tocopherol isolated from seeds. Five new compounds - tetradecyl 13- methylpentadecanoate, tetradecyl 11- methyltridecanoate, 14- oxotricosanoic acid and 15- oxotricosanoic acid are isolated from rhizomes. From the roots 31-norcycloartanone, cycloartenol, cycloartenol and cyclolaudenolware isolated, Methyl 3-(4-hydroxyphenyl)-2E propanone was isolated from rhizomes (Sabita Rani et al., 2012).

Costus specious shows Antidiabetic activity and hypolipidemic activity (Bavarva and Narasimhacharya, 2008) Hepatoprotective activity (Verma and Khosa, 2009) Anticholinesterase activity, Antibacterial activity, Antifungal activity,

Adaptogenic activity, Antioxidant activity, Antilnfalammatory, and Antipyretic Properties, Antihelmintic activity, Oestrogenic activity, CNS depressant, Antiviral, Antigenotoxic, and anti-histopathologic activity, Anticariogenic activity, Antifertility activity (Jyotirmay and Sharma, 2016).

The genus Cyperus rotundas includes common weeds found in upland and paddy fields in temperate to tropical regions. In Asian countries, the rhizomes of Cyperusrotundus, which are used as traditional folk medicines for the treatment of stomach and bowel disorders, and inflammatory diseases, have been wide, investigated ( Thebtaranonth et. al., 1995) Cyperusrotundus (Cyperaceae) is a traditional herbal medicine used widely as an analgesic, sedative, antispasmodic, antimalarial, stomach disorders and to relieve diarrhea (Zhu et. al., 1995) The tuber part of C. rotundus is one of the oldest known medicinal plants used for the treatment of dysmenorrhea and menstrual irregularities (Bhattarai, 1993) Infusion of this herb has been used in pain, fever, diarrhea, dysentery, an emmenagogue, and other intestinal problems. (Uddin et.al., 2006).

Mollugo cerviana (L.)Ser is an herb existing in southern parts of India and it is reported to have antimicrobial and anti-inflammatory properties ( Sadique et. al., 1987) Especially it is seen in all the districts of Tamilnadu. Mollugo cerviana (L.)Ser has two subspecies namely Mollugo cerviana var. spathulifotia and Mollugo cerviana var. cerviana. it usually found as a weed in wheat paddy field (Kumar and Duggal, 2017). It is commonly known as thread stem, carpetweed and in Tamil, it is parpaadagam or Pada (Warner and Nambiar, 1993). The extracts of Mollugo cerviana (L.)Ser can act as a uterine stimulant, antiseptic, febrifuge (Pullaiah, 2006) and it is also used to treat jaundice (Valarmathi eta/., 2011), Beside this, in India, it is identified as a suppressor of stomach ache and to promote vaginal discharge after childbirth. It also enhances eyesight, reduces body odor, the decoction of flowers and tender shoots are used to treat diaphoretic effect. Roots are used in gout and rheumatism (Kapoor et. al., 2017) The presence of C-glycosyl flavonoids compounds are found in Mollugo species. In 2012, it was reported that crude extract of Mollugo cerviana and n-butanol fraction contains alkaloids, saponins, flavonoids, tannins, glycosides, triterpenoids, and phenolic groups while the ethyl acetate fraction contains active constituents like saponins, glycoside, triterpenoids, and steroids. The hepatoprotective activity of Mollugo cerviana was assessed In CCI4 treated liver cells. The extract exhibited a positive effect on hepatocytes due to the presence of essential phytoconstituents such as flavonoids, saponins, terpenoids, and tannins. Aqueous extracts of Mollugo cerviana in 1 mg/ml concentration were tested for UV absorption and the sun protection factor (SPF) was identified as 25 which was higher than the commercially available products (Napagoda, et. a/., 2016). Valarmathy et al., (2015) checked the free radical scavenging activity of methanol extracts by using 1,1- diphenyl-2, 2- picryl hydroxyl free radical (DPPH) assay method. The in-vitro model exhibited a different level of antioxidant activity where the Mollugo cerviana extract showed significant activity (84.12 ± 1.06%) and the percentage inhibition of nitric oxide scavenging activity was significant (60.56 ± 2.74) at a concentration of 400 μg/ml.

Andrographis paniculate (King of bitters), commonly known as Kalmegh has belonged to the family of Acanthaceae. It is used to treat hepatitis, gastrointestinal tract and upper respiratory infections, fever, herpes, anti-diabetic, and a variety of other chronic and infectious diseases. Andrographis paniculate possesses hepatoprotective, antipyretic, anti-inflammatory, immunostimulatory, antipyretic, antioxidant, hypotensive, antibacterial activities, antiplasmodial, anticold, immunomodulatory, and cardiovascular effect. Andrographis paniculata contains steroids, phenols, terpenoids, alkaloids, saponins, flavonoids were the active compounds present in the plant. The medicinal value of this plant is due to the presence of active ingredients viz andrographolide and neoandrographolide which are derivatives of diterpenoids. Andrographolide, neoandrographolide and 14- deoxyll, 12- didehydroandrographolide are reported to be viricidal against herpes simplex virus 1 (HSV-1) without having any significant cytotoxicity at viricidal concentrations (Dua et. al., 2009) Aqueous extracts of the leaves inhibited HIV-1 infection and replication in the lymphoid cell line MOLT-4 (Yao, 1992).

The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine. This plant is inexpensive, readily available, and effective for many diseases, including cancer, inflammation, depression, diabetes, obesity, and hepatotoxicity. The primary constituents isolated from various parts of P.longum are pipeline, piper-lingguine, sylvatin, sesamin, diaeudesmin piperlonguminine, pipermonaline, and piperundecalidine. It is most commonly used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, chronic malaria, viral hepatitis, respiratory infections, stomach ache, bronchitis, diseases of the spleen, cough, and tumors. An infusion of P. longum root is used after birth to induce expulsion of the placenta (Kirtikar and Basu, 1980). The reported pharmacological activities include the following: Anticancer, Hepatoprotective, Antioxidant, Anti-inflammatory, Immunomodulatory, Coronary vasodilation, Antimicrobial, Bioavailability-enhancing, Antiplatelet, Antifertility, Antihyperlipidemlc, Antiobesity, Analgesic, Larvicidal, Adulticidal, Radioprotective, Melanin-inhibiting, Cardioprotective, Antidepressant, Antifungal, and Antiamoebic.

According to the United States Patent Application 20060147554 titled "Ayurvedic herbal soft drink": The invention provides a novel herbal soft drink comprising decoction of plants selected from Sidasps., Vitis vinifera, Withania somnifera, Boerhaavia diffusa and Tinospora cordifolia for the protection and prevention of health and in particular, but not exclusively with antioxidant, immunoenhancing, hepatoprotective, cardiotonic, diuretic, digestive, choleretic, nervine relaxant properties.

According to the United States Patent Application 20160250181 titled "Alternative ACT with Natural Botanical Active GRAS Ingredients for Treatment and Prevention of the ZIKA Virus": An all-natural active ingredient herbal compositions and methods of preparing the same are provided. The novel Artemisinin Combination Therapy (ACT) consists of artemisinin, derivatives of artemisinin, berberine, capsaicin, and Tinospora Cordifolia. When formulated in a gel cap, the composition can consist of only artemisinin, berberine, capsaicin, and Tinosporacordifolia. A blended mixture and inert ingredients, such as selected excipient compounds, are mixed together with artemisinin, berberine, capsaicin, and Tinosporacordifolia and compressed to form a single pill, tablet, or capsule for the treatment of Zika virus. A tablet or pill for children is formulated to be chewable.

According to the United States Patent Application 20190134124 titled Herbal composition for treatment and management of infectious diseases and methods of preparation thereof: Herbal composition for treatment and management of Infectious diseases and methods of preparation are disclosed herein. The disclosed composition including herbs and bhasmas may be used to treat Infectious diseases such as bacterial infection, fungal infection, viral infections, Pharyngitis, Laryngitis, and Bronchitis, etc. The method disclosed herein may be used as the main line of treatment or as supportive medication.

The invention also daims a composition comprising at least one herb or extract thereof selected from a group consisting of Solarium xanthocarpum, Tinospora cordifolia, Zingiber officinalis, Tragia involucrata, Clerodendrum serratum, Cyperus rotundus, Piper longum, Andrographis paniculata, Mollugo cerviana, and Costus speciosus.

OBJECTIVE OF THE INVENTION

The main objective of the invention includes the preparation of a composition of herbal extract that can be used for the prevention, treatment, and management of infectious diseases. For this, herbal plants in a specified variety and parts are used in the desired quantity.

SUMMARY In this preparation, herbs of matured plants were collected with caution. The desired parts of the plants were used for the preparation of medicine. They were cleaned with potable water to remove the soil and extraneous matter presented over them. The excess water presented over them was whipped off with a clean cotton cloth. After ensuring the cleanliness of the ingredients, they were cut into small pieces and dried under the shadow. After drying to the sufficient level, the herbs of the equal quantity were taken as per the traditional Siddha formula (Table 1). The herbs were pounded into the form of coarse powder. Add 1350 ml of water and allow the herbs to completely soak in water for two to three hours. Start boiling the content in a wide mouth pot under a mild flame without the lid. This will help to evaporate the water. Stir the content with ladle continuously. Boil the content until it reduces the volume to one-fourth of its initial quantity. Filter the supernatant with a clean cloth immediately. The prepared Sarva Jura Kudineerplusmay be used within 3 hours and for an extended period with appropriate preservatives. DETAILED DESCRIPTION OF THE INVENTION

A composition is prepared for the treatment and management of bacterial and viral diseases, comprising ingredients of desired parts of Solanum xanthocarpum, Tinospora cordifolia, Zingiber officinalis, Tragia invoiucrata, Clerodendrum serratum, Cyperus rotundus, Piper iongum, Andrographis paniculata, Mollugo cerviana, and Costus speciosus. The said raw materials are collected and washed with clean water. They are cut into small pieces and dried in the shadow. Next, the raw materials are pounded and made into a coarse powder.

In a wide-open mouth vessel, a specified quantity of water is added and the coarse powder is soaked for 2 to 3 hours. The compound is heated mildly and continuously stirred. The heating process is continued until the content is reduced to one-fourth of its volume. Filter the obtained extract with a clean cloth. Use the extract within 3 hours and for an extended period with appropriate preservatives. This extract can be used as a "Kashayam".

The final extract or composition has an antipyretic effect for bacterial and certain viral infections such as Coronavirus (COVID-19) H1N1 , ZIKA virus, HIV, Hanta virus, Ebola virus, etc.

The common names and the botanical names of the ingredients (in English and Tamil) are:

SARVA SURA KUDINEER - INGREDIENTS AND THEIR BIOACTIVE COMPOUNDS/ ALKALOIDS

Method of preparation

Boiling the drug in water in for a definite period of time and reducing it to the specific quantity is called Kasayam.

In this preparation, herbs of matured plants were collected with caution. The desired parts of the plants in the required quantity were used for the preparation of medicine. They were cleaned with potable water to remove the soil and extraneous matter presented over them. The excess water presented over them was whipped off with a clean cotton cloth. After ensuring the cleanliness of the ingredients, they were cut into small pieces and dried under the shadow. After drying to the sufficient level, the herbs of the required quantity were taken as per the traditional Siddha formula (Table 1). The herbs were pounded into the form of coarse powder. Add 1350 ml of water and allow the herbs to completely soak in water for two to three hours. Start boiling the content in a wide mouth pot under a mild flame without the lid helps to evaporate the water. Stir the content with ladle continuously. Boil the content until it reduces its volume to one-fourth of its initial quantity. Filter the supernatant with a clean cloth immediately. The prepared Sarva Jura Kudineercan be used within 3 hours and for an extended period with appropriate preservatives.

Collection of raw materials

Clean with potable water

Wipe off with a clean cloth

Cut into small pieces

Dry it under the shadow Pounding

Make into a coarse powder

Take ingredient as per formula Wide mouth vessel

Add 1350 ml of water

Soak it for 2 to 3 hours

Heat it under mild heat Stir continuously

Reduce the volume to one fourth

Filter with a clean cloth

Use within 3 hours and for an extended period with appropriate preservatives

Fig.1 FLOW CHART FOR THE PREPARATION OF “SARVA JURA KUDINEER”

The filtrate contains most of the active principles of the herb in water-soluble nature and this they form are readily absorbed from the intestine results in faster action. Hence consuming it immediately is one of the best methods to get the maximum benefits of these herbs. The herbs were designed based on mutual compatibility, collective effectiveness to get maximum effect against a particular type of disease and similarly, one herb will mask the side effect of the other herb.

The resultant product has effective against following symptoms like cold, cough, rhinitis, sore throat, bronchitis, asthma, sinusitis, headache, fever of various origin, body ache, nausea, vomiting, thirst, loss of appetite, diarrhea, seizures, anaemia, oedema, fatigue, drowsiness, anxiety, giddiness, depression, insomnia, dysuria, liver diseases, cardiac weakness, diabetes and also has antiviral, antibacterial, antiasthmatic, immunostimulant, anti-inflammatory, analgesic, antipyretic, hepatoprotective, anti-diarrheal, anti-ulcer, antioxidant, anthelmintic, antiplasmodial, a thrombolytic agent, anticancer, anti poisonous effect, laxative, cardiotonic activity, CNS depressant, antihypertensive and anti-epileptic activity against diseases of zoonotic importance or communicable diseases that results in infections due to Corona virus (COVID-19), H1N1, ZIKA virus, HIV, Hantavirus, Ebola vims, etc. and provides clarity of mind.

Claims

1. A composition developed for treatment and management of viral, bacterial diseases comprising ingredients from desired parts of Solanum xanthocarpum, Tinospora cordifolia, Zingiber officinaiis, Tragia involucrata, Clerodendrum serratum, Cyperus rotundus, Piper longum, Andrographis paniculata, MoHugo cerviana, and Costus speciosus and its bioactive compounds/ alkaloids.

2. A method of preparing a composition with the said ingredients as claimed in claim 1.

3. The composition as claimed in claim 1, wherein the said ingredients are added in required quantities.

4. The composition as claimed in claim 1 , wherein said ingredients are dried under the shadow and pounded to make them into a coarse powder.

5. The composition as claimed in claim 1, wherein said ingredients are soaked in a definite quantity of water for a certain period of time.

6. The composition as claimed in claim 1, wherein said ingredients are heated under the mild flame for a certain amount of time to reduce the volume to one- fourth of its initial volume and then filtered.

7. The composition as claimed in claim 1 , where the said preparation used within three hours and for an extended period with appropriate preservatives.

8. The composition as claimed in claim 1 , may include at least one or more herbs or herbs selected from the group of total or part consisting of Solanum xanthocarpum, Tinospora cordifolia, Zingiber officinalis, Tragia invotucrata, Clerodendrum serratum, Cyperus rotundas, Piper longum, Andrographis paniculate, Mollugo cerviana, and Costus speciosus and its extract thereof, alkaloids or bioactive compounds.