WO2021176264A1 - Compositions liposomales et leur procédé de préparation - Google Patents

Compositions liposomales et leur procédé de préparation Download PDF

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Publication number
WO2021176264A1
WO2021176264A1 PCT/IB2020/058105 IB2020058105W WO2021176264A1 WO 2021176264 A1 WO2021176264 A1 WO 2021176264A1 IB 2020058105 W IB2020058105 W IB 2020058105W WO 2021176264 A1 WO2021176264 A1 WO 2021176264A1
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WO
WIPO (PCT)
Prior art keywords
active ingredient
solvent
liposomal composition
weight ratio
vitamin
Prior art date
Application number
PCT/IB2020/058105
Other languages
English (en)
Inventor
Yogesh Dound
Original Assignee
Yogesh Dound
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yogesh Dound filed Critical Yogesh Dound
Publication of WO2021176264A1 publication Critical patent/WO2021176264A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Definitions

  • the present invention relates to a liposomal composition
  • a liposomal composition comprising an active ingredient, lipids as encapsulation material and a solvent, wherein the encapsulation material and solvent are present in a weight ratio of 1:1 to 1:5 and active ingredient and solvent are present in a weight ratio of 1 : 1 to 1 :5.
  • the present invention relates to a liposomal composition
  • a liposomal composition comprising an active ingredient, lipids as encapsulation material and a solvent, wherein the encapsulation material and solvent are present in a weight ratio of 1:1 to 1:5 and active ingredient and solvent are present in a weight ratio of 1 : 1 to 1 :5.
  • primary emulsifiers are selected from the group consisting of; dextrin; sodium lauryl sulfate; Polyoxyethylene glycol; alkyl phenol ethers; Polyoxyethylene glycol sorbitan alkyl esters; Sorbitan alkyl esters and Block copolymers of polyethylene glycol and polypropylene glycol; Dioctyl sodium sulfosuccinate (DOSS); Perfluorooctanesulfonate (PFOS); Linear alkyl benzene sulfonates; Lignosulfonate, sodium stearate; Benzalkonium chloride (BAC), Cetylpyridinium chloride (CPC), Benzethonium chloride (BZT); Alkyltrimethylammonium salts: cetyl trimethylammonium bromide (CTAB) and cetyl trimethylammonium chloride (CTAC) and cocam idopropyl betaine.
  • secondary BAC Cetylpyr
  • the accurate selection of liposome preparation method depends the physicochemical characteristics of the material to be entrapped, choice of liposomal ingredients, nature of the medium in which the lipid vesicles are to be dispersed, effective concentration of the entrapped substance, optimum size and shelf life of the vesicle, and batch-to-batch reproducibility.
  • the vitamin-C liposomal composition according to invention is used for the treatment of scurvy or any other indication or as a dietary supplement or as a food additive.
  • the composition can be used as a food additive in bakery products or food products.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition liposomale comprenant un principe actif, des lipides en tant que matériau d'encapsulation et un solvant, le matériau d'encapsulation et le solvant étant présents dans un rapport pondéral de 1 : 1 à 1 : 5 et le principe actif et le solvant étant présents dans un rapport pondéral de 1 : 1 à 1 : 5. Spécifiquement, l'invention concerne une composition liposomale comprenant de la vitamine C, de la curcumine et une coenzyme Q10.
PCT/IB2020/058105 2020-03-02 2020-08-31 Compositions liposomales et leur procédé de préparation WO2021176264A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202021008974 2020-03-02
IN202021008974 2020-03-02

Publications (1)

Publication Number Publication Date
WO2021176264A1 true WO2021176264A1 (fr) 2021-09-10

Family

ID=77613928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2020/058105 WO2021176264A1 (fr) 2020-03-02 2020-08-31 Compositions liposomales et leur procédé de préparation

Country Status (1)

Country Link
WO (1) WO2021176264A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6447443A (en) * 1987-08-13 1989-02-21 Nippon Shoe Liposome
US7364751B2 (en) * 2001-10-10 2008-04-29 Kaneka Corporation Stabilized compositions of aqueous reduced coenzyme Q solution
US20140065061A1 (en) * 2012-08-31 2014-03-06 Signpath Pharma Inc. Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
US20160367480A1 (en) * 2015-06-18 2016-12-22 Joseph Jongeul JEUNG Vitamin c delivery system and liposomal composition thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6447443A (en) * 1987-08-13 1989-02-21 Nippon Shoe Liposome
US7364751B2 (en) * 2001-10-10 2008-04-29 Kaneka Corporation Stabilized compositions of aqueous reduced coenzyme Q solution
US20140065061A1 (en) * 2012-08-31 2014-03-06 Signpath Pharma Inc. Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
US20160367480A1 (en) * 2015-06-18 2016-12-22 Joseph Jongeul JEUNG Vitamin c delivery system and liposomal composition thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HSU, CHING-YUN ET AL.: "Use of lipid Nanocarriers to improve Oral delivery of vitamins", NUTRIENTS, vol. 11, no. 1, 68, 1 January 2019 (2019-01-01), pages 1 - 30, XP055852832 *
JIN, HONG-HAO ET AL.: "Curcumin liposomes prepared with milk fat globule membrane phospholipids and soybean lecithin", JOURNAL OF DAIRY SCIENCE, vol. 99, no. 3, 2016, pages 1780 - 1790, XP029418809, DOI: 10.3168/jds.2015-10391 *
LEE, WEN-CHUAN ET AL.: "Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 395, no. 1-2, 2010, pages 78 - 83, XP027122832 *

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